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https://www.readbyqxmd.com/read/29667636/-the-distribution-of-2-dimethylamino-ethyl-1-hydroxycyclopentyl-phenyl-acetate-in-the-organism-of-the-warm-blooded-animals-after-its-intra-gastric-administration
#1
V K Shormanov, M F Pravdyuk, V Yu Kuzovlev, N V Shabunina
The objective of the present study was to elucidate the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration. The methods applied in the study included thin layer chromatography in silicagel, aci-nitroprosalt staining reaction, UV-spectrophotometry,, and GC-mass spectrometry. The identification and the quantitation of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organs and blood of the warm-blooded animals were carried out within 20, 150, and 360 min after a single intra-gastric administration of 1300 ml of this poisonous substance...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667416/magnesium-poisoning-multi-organ-failure-and-ischemic-colitis-secondary-to-chronic-ingestion-of-a-parapharmacy-product
#2
Carmen Díaz Gómez, Lucía López Amor, Emilio García Prieto, Dolores Escudero Augusto
The article describes the clinical case of a patient with multi-organ failure and ischemic colitis secondary to magnesium poisoning, due to the chronic intake of a parapharmacy product, used for the treatment of chronic constipation. The clinical case is described and a review of the literature is made.
April 18, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29667118/acmt-position-statement-alternative-or-contingency-countermeasures-for-acetylcholinesterase-inhibiting-agents
#3
Andrew Stolbach, Vikhyat Bebarta, Michael Beuhler, Shaun Carstairs, Lewis Nelson, Michael Wahl, Paul M Wax, Charles McKay
First responders and health care providers must prepare to provide care for patients poisoned by acetylcholinesterase (AchE) inhibitor chemical warfare agents or pesticides. However, pre-deployed medical countermeasures (MCMs) may not be sufficient due to production and delivery interruption, rapid depletion of contents during a response, expiration of MCM components, or lack of local availability of approved MCMs. To augment supplies of community-based and forward-deployed nerve agent countermeasures, the American College of Medical Toxicology (ACMT) supports several strategies: (1) The use of expired atropine, diazepam, and pralidoxime auto-injectors and vials if non-expired drugs are unavailable; and (2) Investigation, development, and identification of alternative countermeasures-commonly stocked drugs that are not approved for nerve agent poisoning but are in the same therapeutic class as approved drugs...
April 17, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29666160/most-human-introns-are-recognized-via-multiple-and-tissue-specific-branchpoints
#4
Jose Mario Bello Pineda, Robert K Bradley
Although branchpoint recognition is an essential component of intron excision during the RNA splicing process, the branchpoint itself is frequently assumed to be a basal, rather than regulatory, sequence feature. However, this assumption has not been systematically tested due to the technical difficulty of identifying branchpoints and quantifying their usage. Here, we analyzed ∼1.31 trillion reads from 17,164 RNA sequencing data sets to demonstrate that almost all human introns contain multiple branchpoints...
April 17, 2018: Genes & Development
https://www.readbyqxmd.com/read/29665611/-suicides-of-psychiatric-inpatients-a-systematic-recording-in-switzerland-of-the-years-2000-to-2010
#5
Flavian Ruff, Alexander Hemmer, Christine Bartsch, Nadine Glasow, Thomas Reisch
OBJECTIVE: To analyze characteristics of suicide methods of psychiatric inpatients that were carried out within and outside of psychiatric hospitals in order to identify adequate suicide prevention measures. METHODS: Data of 436 inpatient suicides were included in the data base of all institutes of forensic medicine in Switzerland for the years 2000 - 2010. We compared details of suicide methods that were applied within and outside psychiatric hospitals. RESULTS: About two thirds of all suicides were carried out outside psychiatric hospitals...
April 17, 2018: Psychiatrische Praxis
https://www.readbyqxmd.com/read/29662470/basis-of-virulence-in-enterotoxin-mediated-staphylococcal-food-poisoning
#6
REVIEW
Emilie L Fisher, Michael Otto, Gordon Y C Cheung
The Staphylococcus aureus enterotoxins are a superfamily of secreted virulence factors that share structural and functional similarities and possess potent superantigenic activity causing disruptions in adaptive immunity. The enterotoxins can be separated into two groups; the classical (SEA-SEE) and the newer (SEG-SE l Y and counting) enterotoxin groups. Many members from both these groups contribute to the pathogenesis of several serious human diseases, including toxic shock syndrome, pneumonia, and sepsis-related infections...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29662467/multilocus-sequence-typing-and-virulence-associated-gene-profile-analysis-of-staphylococcus-aureus-isolates-from-retail-ready-to-eat-food-in-china
#7
Xiaojuan Yang, Shubo Yu, Qingping Wu, Jumei Zhang, Shi Wu, Dongli Rong
The aim of this study was to characterize the subtypes and virulence profiles of 69 Staphylococcus aureus isolates obtained from retail ready-to-eat food in China. The isolates were analyzed using multilocus sequence typing (MLST) and polymerase chain reaction (PCR) analysis of important virulence factor genes, including the staphylococcal enterotoxin (SE) genes ( sea , seb , sec , sed , see , seg , seh , sei , sej ), the exfoliative toxin genes ( eta and etb ), the toxic shock syndrome toxin-1 gene ( tst ), and the Panton-Valentine leucocidin-encoding gene ( pvl )...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29661659/the-association-between-heat-waves-and-other-meteorological-parameters-and-snakebites-israel-national-study
#8
Sagi Shashar, Maayan Yitshak-Sade, Roman Sonkin, Victor Novack, Eli Jaffe
BACKGROUND: Published annual estimates report a global burden of 2.5 million snakebite cases and >100,000 deaths. In Israel, envenomations are the third most frequent cause of poisonings that are of moderate to major clinical severity. Most studies focus on the clinical descriptions of snakebites in tropical climates, and we sought to investigate the association between snakebite frequency and meteorological parameters. OBJECTIVE: We sought to investigate the seasonality of snakebites and evaluate the association between increasingly common heat waves and other meteorological parameters and snakebite frequency in a semiarid nontropical climate...
April 13, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29661533/design-synthesis-and-evaluation-of-novel-n-1-fluoroquinolone-derivatives-probing-for-binding-contact-with-the-active-site-tyrosine-of-gyrase
#9
Tyrell R Towle, Chaitanya A Kulkarni, Lisa M Oppegard, Bridget P Williams, Taylor A Picha, Hiroshi Hiasa, Robert J Kerns
Structural studies of topoisomerase-fluoroquinolone-DNA ternary complexes revealed a cavity between the quinolone N-1 position and the active site tyrosine. Fluoroquinolone derivatives having positively charged or aromatic moieties extended from the N-1 position were designed to probe for binding contacts with the phosphotyrosine residue in ternary complex. While alkylamine, alkylphthalimide, and alkylphenyl groups introduced at the N-1 position afforded derivatives that maintained modest inhibition of the supercoiling activity of DNA gyrase, none retained ability to poison DNA gyrase...
March 30, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29661062/poisoned-wine-regulation-chemical-analyses-and-spanish-french-trade-in-the-1930s
#10
Ignacio Suay-Matallana, Ximo Guillem-Llobat
This paper describes the resources, scientific spaces, and experts involved in the study of a mass poisoning caused by the drinking of arsenic-contaminated wine exported from Spain to France in 1932. Local and international periodicals record the poisoning of 300 French sailors, and stressed the commercial implications of the case. We discuss the reports prepared by different experts (mainly physicians, agricultural engineers, and customs chemists). Their work was not limited to preparing technical publications or chemical analyses; they also actively defended the quality of their local wine, and played a major role in the discussions regarding the regulation of the international wine market in the 1930s, when new standards regarding the analysis of wine were being considered...
April 16, 2018: Ambix
https://www.readbyqxmd.com/read/29660673/inspective-and-toxicological-survey-of-the-poisoned-baits-and-bites
#11
Antonella De Roma, Gianluca Miletti, Nicola D'Alessio, Laura Marigliano, Teresa Bruno, Pasquale Gallo, Giovanni Binato, Mauro Esposito
Cases of intentional animal poisonings are still widespread in Italy, even if the improper or malicious use of poisoned baits is banned. This represents a serious threat to pets as well as wildlife species, but also an environmental and human health concern. A retrospective study was performed based on baits sent for toxicological analysis to the laboratories of Istituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM) in Southern Italy over a five year period. Analyses were carried out by using different analytical techniques in relation to the toxicants...
March 31, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29658508/-psychosocial-characteristics-of-alcohol-dependence-patients-committed-self-poisoning-suicide-attempt
#12
V E Pashkovskiy, D V Antonova, G A Prokopovich, A Yu Egorov
AIM: To determine с psychosocial characteristics of alcohol-dependent patients committed self-poisoning suicide attempt. MATERIAL AND METHODS: Individuals, who were admitted to the toxicology department after the self-poisoning suicidal attempt, were studied. The socio-demographic, personal history data together with experimental psychological methods (V.P. Dvorschenko Personality Accentuation Test, AUDIT, Beck Hopelessness and Suicide Intention Scales, Barratt Impulsivity Scale) were used...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29658485/hyperbaric-oxygen-therapy-its-use-in-medical-emergencies-and-its-development-in-hong-kong
#13
J Ks Leung, R Pk Lam
Hyperbaric oxygen therapy is widely accepted as life-saving treatment for decompression illness. Yet its use in acute carbon monoxide poisoning has remained controversial because of inconsistent findings in clinical trials. Hyperbaric oxygen therapy has an adjunctive role in managing gas gangrene, necrotising soft-tissue infection, and crush injury, as supported by case series. Several cases have been reported in the literature detailing the use of hyperbaric oxygen therapy in patients with severe anaemia in whom blood transfusion is not possible...
April 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29657379/a-clinical-conundrum-called-amitraz-poisoning-a-case-report
#14
Sanjith Saseedharan, Edwin Joseph Pathrose, Bhumika Vedraj Madhav
Amitraz is a nonsystemic insecticide and acaricide which is sometimes also used as scabicide. Due to its widespread use, amitraz poisoning has emerged during the past decade and a half although the literatures on human intoxication cases are scarce. Amitraz poisoning can present with numerous symptoms involving central nervous, cardiovascular, and respiratory systems. The mainstay of treatment is supportive and symptomatic. We present the case of a 60-year-old gentleman who was shifted from another hospital in unconscious state with an alleged history of consumption of an unknown substance which later was known to be amitraz...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29657340/critical-consciousness-a-critique-and-critical-analysis-of-the-literature
#15
Alexis Jemal
The education system has been heralded as a tool of liberation and simultaneously critiqued as a tool of social control to maintain the oppressive status quo. Critical consciousness (CC), developed by the Brazilian educator, Paulo Freire, advanced an educational pedagogy to liberate the masses from systemic inequity maintained and perpetuated by process, practices and outcomes of interdependent systems and institutions. If people are not aware of inequity and do not act to constantly resist oppressive norms and ways of being, then the result is residual inequity in perpetuity...
November 2017: Urban Review
https://www.readbyqxmd.com/read/29656567/major-venom-proteins-of-the-fire-ant-solenopsis-invicta-insights-into-possible-pheromone-binding-function-from-mass-spectrometric-analysis
#16
T Das, I Alabi, M Colley, F Yan, W Griffith, S Bach, S T Weintraub, R Renthal
Proteins in the venom of the fire ant Solenopsis invicta have been suggested to function in pheromone binding. Venom from queens and workers contains different isoforms of these proteins, consistent with the differing pheromones they secrete, but questions remain about the venom protein composition and glandular source. We found that the queen venom contains a previously uncharacterized pheromone-binding protein paralogue known as Sol i 2X1. Using imaging mass spectrometry, we located the main venom proteins in the poison sac, implying that pheromones might have to compete with venom alkaloids for binding...
April 15, 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/29656176/underreporting-of-fatal-poisonings-in-brazil-a-descriptive-study-using-data-from-four-information-systems
#17
Andrea Franco Amoras Magalhães, Eloisa Dutra Caldas
Poisoning is a worldwide problem that involves individuals of all ages and a range of chemicals. In this study, fatal poisoning cases that occurred in the Federal District of Brazil (DF) from 2009 to 2013 were described using information from four systems, and the reasons for underreporting of each system were discussed. Data were obtained from the mortality information system (SIM), the notifiable disease information system (SINAN), the poison information center (CIT), and the forensic medicine institute (IML) of the DF...
April 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29655427/enhanced-cleanup-efficiency-hydroxy-functionalized-magnetic-graphene-oxide-and-its-comparison-with-magnetic-carboxyl-graphene-for-prime-pass-through-cleanup-of-strychnine-and-brucine-in-human-plasma-samples
#18
Jian-Bo Ma, Hai-Wen Qiu, Qiu-Hong Rui, Yu-Feng Liao, Yan-Min Chen, Jin Xu, Yun Zhang, Yan Zhu, Yong-Gang Zhao
An enhanced cleanup efficiency hydroxy functionalized-magnetic graphene oxide (EH-Mag-GO) fully covered porous nano-titania as coating has been designed and synthesized. It has been evaluated in PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure for human plasma prior to analysis of strychnine and brucine by liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS). Comparing with the magnetic carboxyl-graphene (Mag-CG), EH-Mag-GO is much more effective for the removal of matrix effect resulted from blood phospholipids...
August 22, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29655422/aptamer-based-microcantilever-array-biosensor-for-profenofos-detection
#19
Chao Li, Guangping Zhang, Shangquan Wu, Qingchuan Zhang
Profenofos, a highly poisonous organophosphorus pesticide, has been widely used in agricultural production. These pesticide residues have seriously influenced food security and threatened human health, and new methods with high sensitivity are greatly needed to detect profenofos. Here, we developed an aptamer-based microcantilever-array sensor operated in stress mode to detect profenofos, with advantages of being a label-free, highly sensitive, one-step immobilization method capable of quantitative and real-time detection...
August 22, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29653183/atropa-belladonna-neurotoxicity-implications-to-neurological-disorders
#20
REVIEW
Gunnar F Kwakye, Jennifer Jiménez, Jessica A Jiménez, Michael Aschner
Atropa belladonna, commonly known as belladonna or deadly nightshade, ranks among one of the most poisonous plants in Europe and other parts of the world. The plant contains tropane alkaloids, including atropine, scopolamine, and hyoscyamine, which are used as anticholinergics in Food and Drug Administration (FDA) approved drugs and homeopathic remedies. These alkaloids can be very toxic at high dose. The FDA has recently reported that Hyland's baby teething tablets contain inconsistent amounts of Atropa belladonna that may have adverse effects on the nervous system and cause death in children, thus recalled the product in 2017...
April 10, 2018: Food and Chemical Toxicology
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