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Neuroprotection in septic encephalopathy

Koji Hoshino, Mineji Hayakawa, Yuji Morimoto
Sepsis-associated encephalopathy is a major complication during sepsis, and an effective treatment remains unknown. Although minocycline (MINO) has neuroprotective effects and is an attractive candidate for treating sepsis-associated encephalopathy, the effect of MINO on synaptic plasticity during sepsis is still unclear. In the present study, we investigated the effects of MINO on long-term potentiation (LTP) in the hippocampus in a cecal ligation and puncture (CLP) mouse model. We divided mice into four groups; sham + vehicle, sham + MINO (60 mg/kg, i...
August 2017: Shock
Wenyu Liu, Jia'nan Guo, Jie Mu, Linyu Tian, Dong Zhou
The purpose of this study is to test the hypothesis that the mammalian target of rapamycin (mTOR) signaling pathway might mediate neuroprotection in a mouse model of septic encephalopathy and also to identify the role of autophagy. Mice were subjected to cecal ligation and puncture (CLP) or a sham operation, and all 50 mice were randomly assigned to five groups: sham, CLP+ saline, CLP+ rapamycin (1, 5, 10 mg/kg) groups. Two weeks after the operation, Morris water maze was conducted for behavioral test; Nissl staining was used for observing glia infiltration; immunohistochemical staining and biochemical measures in hippocampi were performed to detect mTOR targets and autophagy indicators...
October 2017: Cellular and Molecular Neurobiology
Mauricio Magalhães, Francisco Paulo Martins Rodrigues, Maria Renata Tollio Chopard, Victoria Catarina de Albuquerque Melo, Amanda Melhado, Inez Oliveira, Clery Bernardi Gallacci, Paulo Roberto Pachi, Tabajara Barbosa Lima Neto
CONTEXT AND OBJECTIVE: Neonatal hypoxic-ischemic encephalopathy is associated with high morbidity and mortality. Studies have shown that therapeutic hypothermia decreases neurological sequelae and death. Our aim was therefore to report on a three-year experience of therapeutic hypothermia among asphyxiated newborns. DESIGN AND SETTING: Retrospective study, conducted in a university hospital. METHODS: Thirty-five patients with perinatal asphyxia undergoing body cooling between May 2009 and November 2012 were evaluated...
July 2015: São Paulo Medical Journal, Revista Paulista de Medicina
Ting Zhou, Lei Zhao, Rui Zhan, Qihua He, Yawei Tong, Xiaosheng Tian, Hecheng Wang, Tao Zhang, Yaoyun Fu, Yang Sun, Feng Xu, Xiangyang Guo, Dongsheng Fan, Hongbin Han, Dehua Chui
Blood-brain barrier (BBB) dysfunction is a key event in the development of many central nervous system (CNS) diseases, such as septic encephalopathy and stroke. 4,4'-Diaminodiphenylsulfone (DDS, Dapsone) has displayed neuroprotective effect, but whether DDS has protective role on BBB integrity is not clear. This study was designed to examine the effect of DDS on lipopolysaccharide (LPS)-induced BBB disruption and oxidative stress in brain vessels. Using in vivo multiphoton imaging, we found that DDS administration significantly restored BBB integrity compromised by LPS...
October 24, 2014: Biochemical and Biophysical Research Communications
Man Huang, Chunhui Liu, Yueyu Hu, Pengfei Wang, Meiping Ding
BACKGROUND: Brain dysfunction is a frequent complication of sepsis, usually defined as sepsis-associated encephalopathy (SAE). Although the Notch signaling pathway has been proven to be involved in both ischemia and neuronal proliferation, its role in SAE is still unknown. Here, the effect of the Notch signaling pathway involved γ-secretase inhibitor DAPT on SAE in septic rats was investigated in a cecal ligation and puncture (CLP) model. METHODS: Fifty-nine Sprague-Dawley rats were randomly divided into four groups, with the septic group receiving the CLP operation...
2014: Chinese Medical Journal
Konstanze Plaschke, Franziska Bent, Sören Wagner, Markus Zorn, Jürgen Kopitz
Levosimendan shows protective myocardial characteristics and is administered to enhance cardiac contractility in patients. However, currently little is known about levosimendan's effect on brain. The aim of this pilot study was to investigate the long-term effect of levosimendan on brain and during mild rat sepsis in comparison to its peripheral mode of action. Adult rats (n=40) were divided into four groups with n=10 per group: (I) sham, (II) levosimendan (283 μg/kg body weight i.v.), (III) lipopolysaccharide (LPS, 8 mg/kg body weight i...
February 7, 2014: Neuroscience Letters
Jing Wu, Lin Dong, Mingqiang Zhang, Min Jia, Guangfeng Zhang, Lili Qiu, Muhuo Ji, Jianjun Yang
Accumulating evidence suggests that histone deacetylase inhibitor exert neuroprotective effects in animal models of neurological diseases. We investigated for the first time whether class I histone deacetylase inhibitor valproic acid (VPA) can reverse cognitive deficits in a mouse model of sepsis-associated encephalopathy (SAE). Moreover, the possible mechanisms of protection were also explored. A mouse model of SAE was induced in adult male mice by cecal ligation and puncture (CLP). Mice received an administration of saline or VPA (100 mg/kg) once daily for 14 consecutive days starting either immediately or 2 weeks after operation...
November 2013: Neurochemical Research
Ting-Fa Zhou, Jin-Gui Yu
BACKGROUND: Septic encephalopathy is characterized by changes in mental status and an increase in neuronal apoptosis. Accumulating evidence has shown that recombinant human erythropoietin (rhEPO) protects brain against ischemia and hypoxia injury. However, whether rhEPO exerts neuroprotective effects on septic encephalopathy remains unclear. We designed the current study to evaluate possible neuroprotection of rhEPO in a model of sepsis. METHODS: For this in vitro study, we determined hippocampal neuronal apoptosis by lactate dehydrogenase release, cell counting kit-8 assay, and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling staining after treatment with lipopolysaccharide...
July 2013: Journal of Surgical Research
Di Chen, Hao Pan, Chunwen Li, Xiucai Lan, Beibei Liu, Guangtian Yang
To investigate the interaction and involvement of sodium hydrosulfide (NaHS), a H(2)S donor, on hippocampus of rats suffering from sepsis-associated encephalopathy, rats were subjected to cecal ligation and puncture (CLP)-induced sepsis. Adult male Sprague-Dawley rats were randomly divided into four groups: Sham group, CLP group, CLP+NaHS group and CLP+aminooxyacetic acid (AOAA, an inhibitor of H(2)S formation) group. The four groups were observed at 3, 6, 9, 12 h after treatment. We examined hippocampal H(2)S synthesis and the expression of cystathionine-β-synthetase (CBS), a major enzyme involved in the H(2)S synthesis in hippocampus...
October 2011: Journal of Huazhong University of Science and Technology. Medical Sciences
Verena Eggers, Katja Fügener, Ortrud Vargas Hein, Hans Rommelspacher, Melvyn P Heyes, Wolfgang J Kox, Claudia D Spies
OBJECTIVE: To investigate antibiotic-mediated release of tumour necrosis factor (TNF)-alpha and norharman in patients with hospital-acquired pneumonia with and without additional septic encephalopathy. DESIGN: Prospective observational study with a retrospective post hoc analysis. SETTING: Surgical intensive care unit (ICU) at a university hospital. PATIENTS: Thirty-seven patients were consecutively included (9 patients with hospital-acquired pneumonia, 11 patients with hospital-acquired pneumonia and septic encephalopathy, 17 control patients) in the study...
August 2004: Intensive Care Medicine
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