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https://www.readbyqxmd.com/read/28567281/toward-elimination-of-mother-to-child-transmission-of-hiv-in-south-africa-how-best-to-monitor-early-infant-infections-within-the-prevention-of-mother-to-child-transmission-program
#1
Gayle G Sherman, Ahmad Haeri Mazanderani, Peter Barron, Sanjana Bhardwaj, Ronelle Niit, Margaret Okobi, Adrian Puren, Debra J Jackson, Ameena Ebrahim Goga
BACKGROUND: South Africa has utilized three independent data sources to measure the impact of its program for the prevention of mother-to-child transmission (PMTCT) of HIV. These include the South African National Health Laboratory Service (NHLS), the District Health Information System (DHIS), and South African PMTCT Evaluation (SAPMTCTE) surveys. We compare the results of each, outlining advantages and limitations, and make recommendations for monitoring transmission rates as South Africa works toward achieving elimination of mother-to-child transmission (eMTCT)...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28443275/integration-of-hiv-testing-into-maternal-newborn-and-child-health-weeks-for-improved-case-finding-and-linkage-to-prevention-of-mother-to-child-transmission-services-in-benue-state-nigeria
#2
Olusoji Akinleye, Gideon Dura, Arjan de Wagt, Abiola Davies, Dick Chamla
BACKGROUND: In Nigeria, maternal, newborn, and child health (MNCH) weeks are campaign-like events designed to accelerate progress toward Millennium Development Goals. The authors examined whether integrating HIV testing into MNCH weeks was feasible and could lead to increased case finding and linkage to prevention of mother-to-child transmission (PMTCT) services. METHODS: Pregnant women attending MNCH week during the first week of December 2014 in 13 local government areas in Benue State were provided with HIV tests and referrals to PMTCT services...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28399841/building-a-research-registry-for-studying-birth-complications-and-outcomes-in-six-palestinian-governmental-hospitals
#3
Sahar Hassan, Ase Vikanes, Katariina Laine, Khaled Zimmo, Mohammad Zimmo, Espen Bjertness, Erik Fosse
BACKGROUND: Electronic-health (e-health) provides opportunities for quality improvement of healthcare, but implementation in low and middle income countries is still limited. Our aim was to describe the implementation of a registration (case record form; CRF) for obstetric interventions and childbirth events using e-health in a prospective birth cohort study in Palestine. We also report the completeness and the reliability of the data. METHODS: Data on maternal and fetal health was collected prospectively for all women admitted to give birth during the period from 1st March 2015 to 31st December 2015 in three governmental hospitals in Gaza and three in the West Bank...
April 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28337706/clinical-and-radiological-outcomes-of-two-level-endoscopic-posterior-cervical-foraminotomy
#4
Myung Soo Youn, Myeong Hwan Shon, Yoon Jae Seong, Jong Ki Shin, Tae Sik Goh, Jung Sub Lee
PURPOSE: The efficacy and safety of endoscopic posterior cervical foraminotomy (EPCF) have been demonstrated for single-level cervical radiculopathy, but no report in the medical literature has described the clinical results of two-level EPCF. The aim of this study was to assess the clinical and radiological outcomes of two-level EPCF performed in patients with cervical radiculopathy. METHODS: Twenty-two consecutive patients (9 females and 13 males) that underwent two-level EPCF with cervical radiculopathy from January 2012 to January 2014 were included in this study...
March 23, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28131569/histidine-deficiency-has-a-negative-effect-on-lactational-performance-of-dairy-cows
#5
RANDOMIZED CONTROLLED TRIAL
F Giallongo, M T Harper, J Oh, C Parys, I Shinzato, A N Hristov
A 10-wk randomized complete block design experiment with 24 Holstein cows was conducted to investigate the long-term effects of feeding a His-deficient diet on lactational performance of dairy cows. Cows were blocked by days in milk, milk yield, and parity, and randomly assigned to 1 of the following 2 treatments: (1) His-adequate diet [HAD; providing +166 g/d over metabolizable protein (MP) requirements, according to the National Research Council (2001) and digestible His (dHis) supply of 68 g/d, or 2.5% of MP requirements] and (2) His-deficient diet (HDD; +37 g/d over MP requirements and dHis supply of 49 g/d, or 1...
April 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27943285/annual-research-review-digital-health-interventions-for-children-and-young-people-with-mental-health-problems-a-systematic-and-meta-review
#6
REVIEW
Chris Hollis, Caroline J Falconer, Jennifer L Martin, Craig Whittington, Sarah Stockton, Cris Glazebrook, E Bethan Davies
BACKGROUND: Digital health interventions (DHIs), including computer-assisted therapy, smartphone apps and wearable technologies, are heralded as having enormous potential to improve uptake and accessibility, efficiency, clinical effectiveness and personalisation of mental health interventions. It is generally assumed that DHIs will be preferred by children and young people (CYP) given their ubiquitous digital activity. However, it remains uncertain whether: DHIs for CYP are clinically and cost-effective, CYP prefer DHIs to traditional services, DHIs widen access and how they should be evaluated and adopted by mental health services...
April 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27630020/understanding-factors-affecting-patient-and-public-engagement-and-recruitment-to-digital-health-interventions-a-systematic-review-of-qualitative-studies
#7
Siobhan O'Connor, Peter Hanlon, Catherine A O'Donnell, Sonia Garcia, Julie Glanville, Frances S Mair
BACKGROUND: Numerous types of digital health interventions (DHIs) are available to patients and the public but many factors affect their ability to engage and enrol in them. This systematic review aims to identify and synthesise the qualitative literature on barriers and facilitators to engagement and recruitment to DHIs to inform future implementation efforts. METHODS: PubMed, MEDLINE, CINAHL, Embase, Scopus and the ACM Digital Library were searched for English language qualitative studies from 2000 - 2015 that discussed factors affecting engagement and enrolment in a range of DHIs (e...
2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27350934/the-burden-of-tetanus-in-uganda
#8
Barbara Nanteza, Moses Galukande, Jane Aceng, Joshua Musinguzi, Alex Opio, Anthony K Mbonye, Eddie Mukooyo, Prosper Behumize, Fredrick Makumbi
BACKGROUND: The successful scale-up of safe male circumcision (SMC) in Uganda has been hinged on client's safety and quality of services. However, after the recent three tetanus deaths after circumcision a review of all tetanus cases in one of the hospitals where the cases occurred was initiated. This was to ascertain the potential for an association between tetanus infection and circumcision. Routinely collected national data were also reviewed to determine the burden of tetanus in Uganda and contextualize these incidents...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27032856/distribution-incidence-prevalence-and-default-of-patients-with-diabetes-mellitus-accessing-public-healthcare-in-the-11-districts-of-kwazulu-natal-south-africa
#9
Nikita Sahadew, Veena S Singaram, Susan Brown
BACKGROUND: The global increase in the prevalence of diabetes mellitus is most marked in African countries. The District Health Information System (DHIS) is the primary data collection system of the Department of Health in KwaZulu-Natal Province (KZN), South Africa. Data are routinely collected at all public healthcare facilities in the province and are aggregated per facility. OBJECTIVE: To investigate the distribution, incidence and prevalence of diabetes in the public healthcare sector of KZN...
2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27030460/dress-syndrome-potentially-induced-by-allopurinol-and-triggered-by-influenza-vaccine
#10
Berna Solak, Bahar Sevimli Dikicier, Rabia Oztas Kara, Teoman Erdem
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome (DHIS), is an acute, potentially life-threatening disease that includes skin rash, fever, haematological abnormalities and multiorgan involvement. Although its aetiopathogenesis is not exactly known, it is thought that inefficient drug detoxification leading to the accumulation of drug reactive metabolites causes autoimmune responses in skin and some internal organs, alters immune responses and induces reactivation of viral infections in people who have genetic predisposition...
March 30, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27000164/pharmacists-perceived-knowledge-of-and-confidence-in-dispensing-oral-antineoplastic-agents
#11
Lindsey Dayer, Eddie Dunn, Anne Pace, Schwanda Flowers
OBJECTIVES: To assess community pharmacists' perceived confidence with counseling patients about oral antineoplastic agents, in identifying drug and/or herbal interactions with these agents, and with identifying adverse drug events. METHODS: Four hundred pharmacists were contacted and asked to take an anonymous survey regarding 11 oral antineoplastic agents (OAAs) and the oral antineoplastic market place in general. RESULTS: With a response rate of 61...
March 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/26907320/assessment-of-burden-of-malaria-in-gwanda-district-zimbabwe-using-the-disability-adjusted-life-years
#12
Resign Gunda, Moses John Chimbari, Samson Mukaratirwa
Malaria is one of the highest contributors to morbidity and mortality in Zimbabwe. However, there is paucity of knowledge regarding disability adjusted life years (DALYs) as a measure of burden of malaria in affected communities. The DALYs metric was used to assess the burden of malaria in Gwanda District with the aim of contributing to a better understanding of the impact of disease on affected communities. Data was collected from health facility malaria registers and the District Health Information System (DHIS) to estimate DALYs at household and district levels respectively...
February 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/26799116/reconstitution-of-degenerated-ovine-lumbar-discs-by-stro-3-positive-allogeneic-mesenchymal-precursor-cells-combined-with-pentosan-polysulfate
#13
David Oehme, Peter Ghosh, Tony Goldschlager, Silviu Itescu, Susan Shimon, Jiehua Wu, Courtney McDonald, John M Troupis, Jeffrey V Rosenfeld, Graham Jenkin
OBJECTIVE Disc degeneration and associated low-back pain are major causes of suffering and disability. The authors examined the potential of mesenchymal precursor cells (MPCs), when formulated with pentosan polysulfate (PPS), to ameliorate disc degeneration in an ovine model. METHODS Twenty-four sheep had annular incisions made at L2-3, L3-4, and L4-5 to induce degeneration. Twelve weeks after injury, the nucleus pulposus of a degenerated disc in each animal was injected with ProFreeze and PPS formulated with either a low dose (0...
May 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/26363572/a-hospital-based-surveillance-system-to-assess-the-burden-of-trauma-in-kwazulu-natal-province-south-africa
#14
Elizabeth Lutge, Nirvasha Moodley, Aida Tefera, Benn Sartorius, Timothy Hardcastle, Damian Clarke
INTRODUCTION: In response to the ongoing excessive burden of trauma in South Africa the Data Management and Epidemiology Units of the Department of Health in conjunction with a group of trauma specialists developed a number of trauma data variables for inclusion on the routine District Health Information System (DHIS). The aim of this study is to describe the process followed and review the 2012-2014 data. METHODOLOGY: The variables collected included: total patient numbers assessed in the emergency room with a diagnosis of trauma; the mechanisms of trauma (blunt assault, motor vehicle accident, pedestrian vehicle accident, stab, gunshot wound, other); any trauma patient admitted to a health facility ward/ICU for longer than 12h; and whether the patient required transfer to a higher centre of care...
January 2016: Injury
https://www.readbyqxmd.com/read/26262137/do-interoperable-national-information-systems-enhance-availability-of-data-to-assess-the-effect-of-scale-up-of-hiv-services-on-health-workforce-deployment-in-resource-limited-countries
#15
Tom Oluoch, David Muturi, Rose Kiriinya, Anthony Waruru, Kevin Lanyo, Robert Nguni, James Ojwang, Keith P Waters, Janise Richards
Sub-Saharan Africa (SSA) bears the heaviest burden of the HIV epidemic. Health workers play a critical role in the scale-up of HIV programs. SSA also has the weakest information and communication technology (ICT) infrastructure globally. Implementing interoperable national health information systems (HIS) is a challenge, even in developed countries. Countries in resource-limited settings have yet to demonstrate that interoperable systems can be achieved, and can improve quality of healthcare through enhanced data availability and use in the deployment of the health workforce...
2015: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/25932347/services-for-mothers-and-newborns-during-the-ebola-outbreak-in-liberia-the-need-for-improvement-in-emergencies
#16
Preetha Iyengar, Kate Kerber, Cuallah Jabbeh Howe, Bernice Dahn
BACKGROUND: The magnitude of the Ebola outbreak in West Africa is unprecedented. Liberia, Guinea, and Sierra Leone are in the bottom ten countries in the Human Development Index, but all had made gains in child survival prior to the outbreak. With closure of healthcare facilities and the loss of health workers secondary to the outbreak, the region risks reversing survival gains achieved in maternal and newborn health. METHODS: Anonymized service utilization data were downloaded from the Liberia District Health Information Software (DHIS) 2 for selected maternal health services at PHC facilities in Margibi and Bong Counties from March 2014, when the first case of Ebola was reported in Liberia, through December 2014...
2015: PLoS Currents
https://www.readbyqxmd.com/read/25841251/digital-health-interventions-for-the-prevention-of-cardiovascular-disease-a-systematic-review-and-meta-analysis
#17
REVIEW
R Jay Widmer, Nerissa M Collins, C Scott Collins, Colin P West, Lilach O Lerman, Amir Lerman
OBJECTIVE: To assess the potential benefit of digital health interventions (DHIs) on cardiovascular disease (CVD) outcomes (CVD events, all-cause mortality, hospitalizations) and risk factors compared with non-DHIs. PATIENTS AND METHODS: We conducted a systematic search of PubMed, MEDLINE, EMBASE, Web of Science, Ovid, CINHAL, ERIC, PsychINFO, Cochrane, and Cochrane Central Register of Controlled Trials for articles published from January 1, 1990, through January 21, 2014...
April 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/25821033/the-double-histidine-cu%C3%A2-%C3%A2-%C2%BA-binding-motif-a-highly-rigid-site-specific-spin-probe-for-electron-spin-resonance-distance-measurements
#18
Timothy F Cunningham, Miriam R Putterman, Astha Desai, W Seth Horne, Sunil Saxena
The development of ESR methods that measure long-range distance distributions has advanced biophysical research. However, the spin labels commonly employed are highly flexible, which leads to ambiguity in relating ESR measurements to protein-backbone structure. Herein we present the double-histidine (dHis) Cu(2+)-binding motif as a rigid spin probe for double electron-electron resonance (DEER) distance measurements. The spin label is assembled in situ from natural amino acid residues and a metal salt, requires no postexpression synthetic modification, and provides distance distributions that are dramatically narrower than those found with the commonly used protein spin label...
May 18, 2015: Angewandte Chemie
https://www.readbyqxmd.com/read/25368765/long-term-clinical-and-radiologic-outcomes-of-minimally-invasive-posterior-cervical-foraminotomy
#19
Young-Joon Kwon
OBJECTIVE: To report long-term clinical and radiological outcomes of minimally invasive posterior cervical foraminotomy (MI-PCF) performed in patients with unilateral single-level cervical radiculopathy. METHODS: Of forty-six patients who underwent MI-PCF for unilateral single-level radiculopathy between 2005 and 2013, 33 patients were included in the study, with a mean follow-up of 32.7 months. Patients were regularly followed for clinical and radiological assessment...
September 2014: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/24917034/substituent-parameters-impacting-isomer-composition-and-optical-properties-of-dihydroindolizine-molecular-switches
#20
Matthew A Bartucci, Jacob W Ciszek
In an attempt to understand which factors influence constitutional isomer control of 6'- and 8'-substituted dihydroindolizines (DHIs), a series of asymmetric pyridines was condensed with dimethyl spiro[cycloprop[2]ene-1,9'-fluorene]-2,3-dicarboxylate. The substituents on the pyridial derivatives ranged from donating to withdrawing and demonstrated control over the isomeric ratios for all DHIs. Substituent control proved to be selective for the highly donating amino, which exclusively formed the 8' isomer. The same ratios were reproduced via photolytic experiments, which suggested that the condensation reaction is dominated by the product's thermodynamic stability...
June 20, 2014: Journal of Organic Chemistry
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