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https://www.readbyqxmd.com/read/29343539/buruli-ulcer-review-of-a-neglected-skin-mycobacterial-disease
#1
Jeannette Guarner
Buruli ulcer is caused by Mycobacterium ulcerans This neglected disease occurs in scattered foci around the world with higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Finding acid fast bacilli in smears or histopathology, culturing the mycobacteria, and performing M. ulcerans PCR in presumptive cases confirms the diagnosis. Medical treatment with oral rifampicin and intramuscular streptomycin or oral treatment with rifampicin plus clarithromycin for 8 weeks is supported by the World Health Organization...
January 17, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29341192/population-pharmacokinetic-modeling-of-guselkumab-a-human-igg1%C3%AE-monoclonal-antibody-targeting-il-23-in-patients-with-moderate-to-severe-plaque-psoriasis
#2
Zhenling Yao, Chuanpu Hu, Yaowei Zhu, Zhenhua Xu, Bruce Randazzo, Yasmine Wasfi, Yang Chen, Amarnath Sharma, Honghui Zhou
Psoriasis is a common inflammatory skin disorder that requires chronic treatment and is associated with multiple comorbidities. Guselkumab, a human immunoglobulin-G1-lambda monoclonal antibody, binds to interleukin-23 with high specificity and affinity and is effective in treating moderate to severe plaque psoriasis. As part of the guselkumab psoriasis clinical trial program, using a confirmatory approach, a population pharmacokinetics (PopPK) model was established using 13 014 PK samples from 1454 guselkumab-treated patients across 3 phase 2/3 trials...
January 17, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29321021/silver-pig-skin-nanocomposites-and-mesenchymal-stem-cells-suitable-antibiofilm-cellular-dressings-for-wound-healing
#3
Mario Alberto Pérez-Díaz, Phaedra Silva-Bermudez, Binisa Jiménez-López, Valentín Martínez-López, Yaaziel Melgarejo-Ramírez, Ana Brena-Molina, Clemente Ibarra, Isabel Baeza, M Esther Martínez-Pardo, M Lourdes Reyes-Frías, Erik Márquez-Gutiérrez, Cristina Velasquillo, Gabriel Martínez-Castañon, Fidel Martinez-Gutierrez, Roberto Sánchez-Sánchez
BACKGROUND: Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-resistant and multidrug-resistant bacteria...
January 10, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29320841/the-role-of-klotho-in-systemic-sclerosis
#4
R Talotta, S Bongiovanni, T Letizia, F Rigamonti, F Atzeni, M Benucci, T Vago, P Sarzi-Puttini
The aim was to evaluate the role of klotho in the pathogenesis of systemic sclerosis (SSc), through the measurement of its serum concentration in SSc patients compared to healthy controls, and to assess the association with cutaneous and visceral involvement. Blood samples obtained from both SSc patients and healthy controls were analysed by an ELISA assay for the detection of human klotho. SSc patients were globally evaluated for disease activity and assessed through the modified Rodnan's Skin Score, Medsger's scale, pulmonary function tests, 2D-echocardiography, nailfold capillaroscopy and laboratory tests...
December 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/29320597/realistic-sunscreen-durability-a-randomized-double-blinded-controlled-clinical-study
#5
Hao Ouyang, Karen Meyer, Prithwiraj Maitra, Susan Daly, Ryan M Svoboda, Aaron S Farberg, Darrell S Rigel
BACKGROUND: Studies show that sunscreen under real-life conditions is often not reapplied and/or applied insufficiently. This study investigated the durability of 2 current sunscreens with different SPF protection over an 8-hour period under simulated real-life conditions. METHODS: Participants (n=24) were randomized into two study groups utilizing either 2 mg/cm2 (FDA testing concentration) or 1 mg/cm2 (real-life application levels) of sunscreen. Two current SPF 15 and 70 sunscreens were applied to test spots on each participant's back...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29318715/comparative-evaluation-of-skin-moisture-after-topical-application-of-10-and-30-lactobionic-acid
#6
Barbara Algiert-Zielińska, Paulina Mucha, Helena Rotsztejn
BACKGROUND: Dry skin is characterized by symptoms such as itching, redness, excessive exfoliation. These symptoms cause discomfort and contribute to secondary bacterial infections. Dry skin treatments are based on topical applications of various formulations. Among many of them are polyhydroxy acids, which recently gained more attention. AIMS: The aim of this study was a comparative assessment of hydration level (corneometric) after application of lactobionic acid (LA) in the form of peel at concentrations of 10% and 30%...
January 9, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29314141/local-immune-response-to-larvae-of%C3%A2-rhipicephalus-microplus%C3%A2-in-santa-gertrudis-cattle-immune-response-against-rhipicephalus-microplus
#7
Constantin Constantinoiu, Ala Lew-Tabor, Louise Jackson, Wayne Jorgensen, Emily Piper, David Mayer, Linda Johnson, Bronwyn Venus, Nicholas Jonsson
AIMS: This study investigated the local immune response at larval attachment sites in Santa Gertrudis cattle with low and high levels of tick resistance. METHODS AND RESULTS: Skin samples with tick larvae attached were collected from Santa Gertrudis cattle at the end of a period of 25 weekly infestations, when the animals manifested highly divergent tick-resistant phenotypes. There was a tendency for more CD3+ , CD4+ , CD8+ , CD25+ , γδ T-cells and neutrophils to concentrate at larval tick attachment site in susceptible cattle than in resistant cattle but the differences were significant only for γδ T-cells and CD4+ cells...
January 4, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29306355/neurophysiology-of-the-pelvic-floor-in-clinical-practice-a-systematic-literature-review
#8
REVIEW
Fiorella Bianchi, Giovanna M Squintani, M Osio, A Morini, C Bana, G Ardolino, M Barbieri, L Bertolasi, R Caramelli, F Cogiamian, A Currà, G de Scisciolo, C Foresti, V Frasca, E Frasson, M Inghilleri, L Maderna, L Motti, E Onesti, M C Romano, U Del Carro
Neurophysiological testing of the pelvic floor is recognized as an essential tool to identify pathophysiological mechanisms of pelvic floor disorders, support clinical diagnosis, and aid in therapeutic decisions. Nevertheless, the diagnostic value of these tests in specific neurological diseases of the pelvic floor is not completely clarified. Seeking to fill this gap, the members of the Neurophysiology of the Pelvic Floor Study Group of the Italian Clinical Neurophysiology Society performed a systematic review of the literature to gather available evidence for and against the utility of neurophysiological tests...
October 2017: Functional Neurology
https://www.readbyqxmd.com/read/29300352/risk-assessment-for-children-exposed-to-arsenic-on-baseball-fields-with-contaminated-fill-material
#9
Alesia C Ferguson, Jennifer C Black, Isaac B Sims, Jennifer N Welday, Samir M Elmir, Kendra F Goff, J Mark Higginbotham, Helena M Solo-Gabriele
Children can be exposed to arsenic through play areas which may have contaminated fill material from historic land use. The objective of the current study was to evaluate the risk to children who play and/or spend time at baseball fields with soils shown to have arsenic above background levels. Arsenic in soils at the study sites located in Miami, FL, USA showed distinct distributions between infield, outfield, and areas adjacent to the fields. Using best estimates of exposure factors for children baseball scenarios, results show that non-cancer risks depend most heavily upon the age of the person and the arsenic exposure level...
January 4, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29295567/minoxidil-induction-of-vegf-is-mediated-by-inhibition-of-hif-prolyl-hydroxylase
#10
Soohwan Yum, Seongkeun Jeong, Dohoon Kim, Sunyoung Lee, Wooseong Kim, Jin-Wook Yoo, Jung-Ae Kim, Oh Sang Kwon, Dae-Duk Kim, Do Sik Min, Yunjin Jung
The topical application of minoxidil may achieve millimolar concentrations in the skin. We investigated whether millimolar minoxidil could induce vascular endothelial growth factor (VEGF), a possible effector for minoxidil-mediated hair growth, and how it occurred at the molecular level. Cell-based experiments were performed to investigate a molecular mechanism underlying the millimolar minoxidil induction of VEGF. The inhibitory effect of minoxidil on hypoxia-inducible factor (HIF) prolyl hydroxylase-2 (PHD-2) was tested by an in vitro von Hippel-Lindau protein (VHL) binding assay...
December 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29290249/a-phase-i-trial-of-afatinib-and-bevacizumab-in-chemo-na%C3%A3-ve-patients-with-advanced-non-small-cell-lung-cancer-harboring-egfr-mutations-okayama-lung-cancer-study-group-trial-1404
#11
Takashi Ninomiya, Naoyuki Nogami, Toshiyuki Kozuki, Daijiro Harada, Toshio Kubo, Kadoaki Ohashi, Shoichi Kuyama, Kenichiro Kudo, Akihiro Bessho, Nobuaki Fukamatsu, Nobukazu Fujimoto, Keisuke Aoe, Takuo Shibayama, Keisuke Sugimoto, Nagio Takigawa, Katsuyuki Hotta, Katsuyuki Kiura
OBJECTIVE: In advanced epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC), treatment with afatinib, a second-generation EGFR-tyrosine kinase inhibitor (TKI), confers a significant survival benefit over platinum-based chemotherapy. The first-generation EGFR-TKIs gefitinib and erlotinib in combination with bevacizumab have improved progression-free survival. We hypothesized that the combination of afatinib with bevacizumab would further improve efficacy, and conducted a phase I trial to test this hypothesis...
January 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29281719/cd14-159c-t-polymorphism-in-the-development-of-delayed-skin-hypersensitivity-to-tuberculin
#12
Magdalena Druszczynska, Marcin Wlodarczyk, Grzegorz Kielnierowski, Michal Seweryn, Sebastian Wawrocki, Wieslawa Rudnicka
The skin tuberculin test (TST), an example of a delayed-type hypersensitivity (DTH) reaction, is based on measuring the extent of skin induration to mycobacterial tuberculin (PPD). Little is known about the genetic basis of TST reactivity, widely used for diagnosing TB infection. The study investigated the relationship of the single base change polymorphic variants in CD14 gene (CD14(-159C/T)) with the development of DTH to PPD in BCG-vaccinated Polish Caucasian individuals. We found persistent lack of TST reactivity in about 40% of healthy subjects despite receiving more than one dose of BCG...
2017: PloS One
https://www.readbyqxmd.com/read/29280518/a-new-tool-to-test-active-ingredient-using-acid-lactic-in-vitro-a-help-to-understand-cellular-mechanism-involved-in-stinging-test-an-example-using-a-bacterial-polysaccharide-fucogel%C3%A2
#13
Mehdi Sakka, Raphael Leschiera, Christelle Le Gall, Olivier Gouin, Killian L'herondelle, Paul Buscaglia, Olivier Mignen, Jean-Luc Philbé, Thibaut Saguet, Jean-Luc Carré, Laurent Misery, Nicolas Lebonvallet
The stinging test is an in vivo protocol that evaluates sensitive skin using lactic acid (LA). A soothing sensation of cosmetics or ingredients can be also appreciated through a decrease of stinging score. To predict the soothing sensation of a product before in vivo testing, we developed a model based on an LA test and substance P (SP) release using a co-culture of human keratinocytes and NGF-differentiated PC12 cells. A bacterial fucose-rich polysaccharide present in Fucogel® was evaluated as the soothing molecule in the in vivo stinging test and our in vitro model...
December 27, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29273134/reliability-of-allergy-skin-testing
#14
Maria Shtessel, Jody Tversky
BACKGROUND: Percutaneous allergen skin testing remains an established benchmark for diagnosing atopic disease. The reliability of skin testing depends greatly on the performance of allergen extracts used, methods used, and the presence of antihistamine medications. OBJECTIVE: To determine the differential effect of cetirizine on 2 different concentrations of histamine control solution and 5 common allergens used for percutaneous skin testing. METHODS: Twelve individuals underwent skin testing with histamine (1 and 6 mg/mL), control diluent, and 5 common aeroallergens...
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29250739/prediction-of-tumor-to-plasma-ratios-of-basic-compounds-in-subcutaneous-xenograft-mouse-models
#15
Prashant B Nigade, Jayasagar Gundu, K Sreedhara Pai, Kumar V S Nemmani
BACKGROUND: Predicting target site drug concentrations is of key importance for rank ordering compounds before proceeding to chronic pharmacodynamic models. We propose generic tumor-specific correlation-based regression equations to predict tumor-to-plasma ratios (tumor-Kps) in slow- and fast-growing xenograft mouse models. METHODS: Disposition of 14 basic small molecules was investigated extensively in mouse plasma, tissues and tumors after a single oral dose administration...
December 18, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29248593/phototoxic-effect-of-oxytetracycline-on-normal-human-melanocytes
#16
Jakub Rok, Dorota Wrześniok, Artur Beberok, Michał Otręba, Marcin Delijewski, Ewa Buszman
Oxytetracycline is a broad-spectrum antibiotic, used in dermatology and veterinary medicine. Like other tetracyclines, it may evoke skin phototoxic reactions related to generation of reactive oxygen species (ROS). Melanins are biopolymers synthesised in melanocytes - highly specialised cells, localised in the basal layer of epidermis. Production of melanin is a defence mechanism against harmful effects of UV radiation, ROS and many chemical substances, including drugs. In the present study the influence of oxytetracycline and UVA radiation on darkly pigmented melanocytes viability, the melanogenesis process and the activity of antioxidant enzymes were analysed...
December 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29247690/dermal-peptide-delivery-using-enhancer-moleculs-and-colloidal-carrier-systems-part-ii-tetrapeptide-pkek
#17
Reinhard H H Neubert, Elfi Sommer, Melanie Schölzel, Benjamin Tuchscherer, Yahja Mrestani, Johannes Wohlrab
Due to the lipophilic properties of the uppermost skin layer of the stratum corneum (SC) it is highly challenging to reach therapeutic concentrations of cosmetic actives and drugs. Particularly, the hydrophilic ones penetrate poorly across the SC. The purpose of this study was to improve the topical bioavailability of the hydrophilic, polar tetrapeptide PKEK (amino acid sequence in one-letter notation). A nano-sized carrier system (microemulsion, ME) was therefore developed since MEs provide excellent penetration enhancing properties...
December 13, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29242014/anti-ige-treatment-with-oral-immunotherapy-in-multifood-allergic-participants-a-double-blind-randomised-controlled-trial
#18
Sandra Andorf, Natasha Purington, Whitney M Block, Andrew J Long, Dana Tupa, Erica Brittain, Amanda Rudman Spergel, Manisha Desai, Stephen J Galli, Kari C Nadeau, R Sharon Chinthrajah
BACKGROUND: Despite progress in single food oral immunotherapy, there is little evidence concerning the safety and efficacy of treating individuals with multiple food (multifood) allergies. We did a pilot study testing whether anti-IgE (omalizumab) combined with multifood oral immunotherapy benefited multifood allergic patients. METHODS: We did a blinded, phase 2 clinical trial at Stanford University. We enrolled participants, aged 4-15 years, with multifood allergies validated by double-blind, placebo-controlled food challenges to their offending foods...
December 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29236803/aldefluor-protocol-to-sort-keratinocytes-stem-cells-from-skin
#19
Samuel Marcos Ribeiro Noronha, Alfredo Gragnani, Thiago Antônio Calado Pereira, Silvana Aparecida Alves Correa, Jessica Bonucci, Lydia Masako Ferreira
PURPOSE: To investigate the use Aldefluor® and N, N - Dimethylaminobenzaldehyde (DEAB) to design a protocol to sort keratinocyte stem cells from cultured keratinocytes from burned patients. METHODS: Activated Aldefluor® aliquots were prepared and maintained at temperature between 2 to 8°C, or stored at -20°C. Next, the cells were collected following the standard protocol of sample preparation. RESULTS: Best results were obtained with Aldefluor® 1...
November 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29229196/impact-of-allergy-on-phenotypic-and-endotypic-profiles-of-nasal-polyposis
#20
G Mortuaire, I Gengler, M Balden, M Capron, G Lefèvre
OBJECTIVES: To assess the impact of allergy on clinical presentations (phenotypes) and inflammatory patterns (endotypes) of chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: A single-center prospective study was conducted over an 18-month period. Fifty-seven patients with refractory CRSwNP were included. The diagnosis of allergy was based on concordant skin prick tests and symptoms. Phenotypes were determined on symptom severity score, polyp size classification and Lund-Mackay CT staging...
December 8, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
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