keyword
MENU ▼
Read by QxMD icon Read
search

skin test concentration

keyword
https://www.readbyqxmd.com/read/28208225/indoor-fungal-diversity-in-primary-schools-may-differently-influence-allergic-sensitization-and-asthma-in-children
#1
João Cavaleiro Rufo, Joana Madureira, Inês Paciência, Lívia Aguiar, Cristiana Pereira, Diana Silva, Patrícia Padrão, Pedro Moreira, Luís Delgado, Isabella Annesi-Maesano, Eduardo Oliveira Fernandes, João Paulo Teixeira, André Moreira
BACKGROUND: Childhood exposure to microbiological agents may influence the development of allergic and respiratory diseases. Apart from home, children spend most of their time at school, which represents an environment of significant exposure to indoor air microbes. Therefore, we aimed to assess how the prevalence of allergic sensitization and asthma in schoolchildren is affected by microbiological exposure within classrooms. METHODS: Spirometry with bronchodilation, exhaled nitric oxide measurements and skin-prick tests data were retrieved from 858 children aged 8 to 10 years old attending 71 classrooms in 20 primary schools...
February 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28197946/alterations-in-the-skin-of-labeo-rohita-exposed-to-an-azo-dye-eriochrome-black-t-a-histopathological-and-enzyme-biochemical-investigation
#2
Ayan Srivastava, Neeraj Verma, Arup Mistri, Brijesh Ranjan, Ashwini Kumar Nigam, Usha Kumari, Swati Mittal, Ajay Kumar Mittal
Histopathological changes and alterations in the activity of certain metabolic and antioxidant enzymes were analyzed in the head skin of Labeo rohita, exposed to sublethal test concentrations of the azo dye, Eriochrome black T for 4 days, using 24 h renewal bioassay method. Hypertrophied epithelial cells, increased density of mucous goblet cells, and profuse mucous secretion at the surface were considered to protect the skin from toxic impact of the azo dye. Degenerative changes including vacuolization, shrinkage, decrease in dimension, and density of club cells with simultaneous release of their contents in the intercellular spaces were associated to plug them, preventing indiscriminate entry of foreign matter...
February 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28197207/maize-fungal-growth-control-with-scopoletin-of-cassava-roots-produced-in-benin
#3
Rafiatou Ba, Teou Alfa, Fernand Gbaguidi, Kosi Mawuéna Novidzro, Kokouvi Dotse, Koffi Koudouvo, Ursula Houngue, Marcel T Donou Hounsode, Kossi Honoré Koumaglo, Yaovi Ameyapoh, Lamine Baba-Moussa
The chemical contamination of food is among the main public health issues in developing countries. With a view to find new natural bioactive products against fungi responsible for chemical contamination of staple food such as maize, the antifungal activity tests of scopoletin extracted from different components of the cassava root produced in Benin were carried out. The dosage of scopoletin from parts of the root (first skin, second skin, whole root, and flesh) was done by High Performance Liquid Chromatography...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28196742/comparison-of-different-skin-preservation-methods-with-gamma-irradiation
#4
Linda Guerrero, Bernardo Camacho
Allografts are in constant demand, not only for burn victims, but also for all open wounds as "biological dressings". Tissue quality and security are two of the major concerns of Tissue Banks. There are limited studies published. There has been extensive discussion on the subject of preservation methods for cadaver skin. Most literature available comes from clinical reports. In this research, the authors compared 85% glycerolized non irradiated skin allografts with three glycerolized irradiated skin allografts (using different glycerol concentrations 50%, 70% and 85%)...
February 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28196457/dermal-absorption-of-fumigant-gases-during-hazmat-incident-exposure-scenarios-methyl-bromide-sulfuryl-fluoride-and-chloropicrin
#5
Sharyn Gaskin, Linda Heath, Dino Pisaniello, John W Edwards, Michael Logan, Christina Baxter
Accidental or intentional releases of toxic gases or vapors are the most common occurrence in hazardous material (HAZMAT) incidents that result in human injuries. The most serious hazard from exposure to gases or vapors is via the respiratory system. Dermal uptake, as a secondary route, is still a concern, most acutely for the unprotected public. There is a limited evidence base describing skin absorption of toxic gases and vapors in HAZMAT exposure scenarios, which are relatively brief compared with traditional test periods for skin absorption studies...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28195449/effects-of-resveratrol-on-the-expression-of-molecules-related-to-the-mtor-signaling-pathway-in-pathological-scar-fibroblasts
#6
Zhiming Tang, Ji-Cun Ding, Xiao-Xiang Zhai
BACKGROUND: We observed the effects of resveratrol on the expression of molecules involved in the mTOR signaling pathway in pathological scar fibroblasts, including PI3K, Akt and mTOR. METHODS: We detected the expression of PI3K, Akt and mTOR in pathological scar and normal skin fibroblasts through immunofluorescence. After being treated with different concentrations of resveratrol, the expression of PI3K, Akt and mTOR mRNA and protein were detected by RT-PCR and Western Blot respectively...
February 14, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28190468/curcuma-aeruginosa-roxb-essential-oil-slows-hair-growth-and-lightens-skin-in-axillae-a-randomised-double-blinded-trial
#7
Jukkarin Srivilai, Preeyawass Phimnuan, Jiraporn Jaisabai, Nantakarn Luangtoomma, Neti Waranuch, Nantaka Khorana, Wudtichai Wisuitiprot, C Norman Scholfield, Katechan Champachaisri, Kornkanok Ingkaninan
BACKGROUND: Androgenic hair-growth contributes to secondary gender characteristics but can be troublesome in women. Inhibiting axillary hair-growth via 5-α-reductases using the Thai medicinal plant, Curcuma aeruginosa Roxb. is an attractive treatment strategy. HYPOTHESIS/PURPOSE: C. aeruginosa essential oil (CA-oil) formulated as a lotion is an efficacious and safe inhibitor of axillary hair growth. STUDY DESIGN: This trial was a single center, randomized, double-blind, placebo controlled 10 weeks, intervention in 60 women (18-23 years) and 2 weeks washout with axillary hair length was the primary end-point...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28181985/artiss-sealant%C3%A2-an-alternative-to-stapling-skin-grafts-on-the-dorsal-side-of-the-hand-and-fingers
#8
David Boccara, Antoine De Runz, Farid Bakara, Marc Chaouat, Maurice Mimoun
The aim of this study was to evaluate the benefit of using a new slow-setting fibrin sealant compared with staples for adherence of split-thickness skin grafts on the backs of hands and fingers. Staple removal is often painful for patients. Twenty-eight patients were included for a graft total of 34 hands. The authors chose to test this sealant on zones that are often difficult to graft given their varied topographies. Its low concentration of thrombin (4 IU/ml) compared with other sealants provides it with prolonged polymerization time (60 seconds) making it easier to use in this location...
February 7, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28174103/leishmania-amazonensis-and-leishmania-chagasi-in-vitro-leishmanicide-activity-of-virola-surinamensis-rol-warb
#9
Andreza Veiga, Kelly Albuquerque, Maria Elinete Corrêa, Helliton Brigido, João Silva E Silva, Marliane Campos, Fernando Silveira, Lourivaldo Santos, Maria Dolabela
Virola species have been used in traditional medicine as healing in skin infections. From V. surinanensis oil were isolated several sesquiterpene as the nerolidol which showed activity against species of Leishmania. The current study aimed to evaluate the leishmanicide activity and toxicity of extracts, fractions and surinamesin obtained from leaves of Virola surinamensis. Hexane, Ethyl Acetate, and Methanol extracts were obtained from powder of dry leaves of V. surinamensis. The hexane and ethyl acetate extracts were fractionated by silica gel column chromatography and increasingly polar gradient...
February 4, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28161442/transdermal-delivery-of-cimetidine-across-microneedle-treated-skin-effect-of-extent-of-drug-ionization-on-the-permeation
#10
Yang Song, Anushree Herwadkar, Meera G Patel, Ajay K Banga
The objective of this work was to optimize a gel formulation of cimetidine to maximize its transdermal delivery across microporated skin. Specifically, the effect of extent of ionization in formulation on permeation of cimetidine across microporated skin was studied. Cimetidine was formulated into a gel using propylene glycol, water and carbopol 980NF. Three strengths of gels (0.1% w/w, 0.5% w/w and 0.8% w/w) were made and Tris base was used to adjust the pH of formulations to pH 5, pH 6.8 and pH 7.5. In vitro permeation testing was performed on vertical Franz cells with dermatomed porcine ear skin...
February 1, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28159477/assessment-of-skin-sensitization-under-reach-a-case-report-on-vehicle-choice-in-the-llna-and-its-crucial-role-preventing-false-positive-results
#11
Nico Watzek, Franz Berger, Susanne Noreen Kolle, Tanja Kaufmann, Matthias Becker, Bennard van Ravenzwaay
In the EU, chemicals with a production or import volume in quantities of one metric ton per year or more have to be tested for skin sensitizing properties under the REACH regulation. The murine Local Lymph Node Assay (LLNA) and its modifications are widely used to fulfil the data requirement, as it is currently considered the first-choice method for in vivo testing to cover this endpoint. This manuscript describes a case study highlighting the importance of understanding the chemistry of the test material during testing for 'skin sensitization' of MCDA (mixture of 2,4- and 2,6-diamino-methylcyclohexane) with particular focus on the vehicle used...
January 31, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28158151/efficacy-and-safety-of-0-625-and-1-25-capsaicin-patch-in-peripheral-neuropathic-pain-multi-center-randomized-and-semi-double-blind-controlled-study
#12
Jee-Youn Moon, Pyung-Bok Lee, Yong-Chul Kim, Sang-Chul Lee, Francis S Nahm, Eunjoo Choi
BACKGROUND: Topical capsaicin therapy may be of benefit in providing pain relief in patients with peripheral neuropathy. OBJECTIVES: To investigate the efficacy and safety of 0.625% (50 µg/cm2) and 1.25% (100 µg/cm2) capsaicin patches (CPs) compared to conventional 0.075% capsaicin cream or placebo patches in patients suffering from peripheral neuropathy. STUDY DESIGN: Early Phase II, multi-center, randomized, semi-double-blind, and placebo-controlled clinical trial...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28157787/nonclinical-evaluation-of-the-new-topical-hemostatic-agent-tt-173-for-skin-grafting-procedures
#13
Santiago Rojas Codina, José Raúl Herance, Alberto Centeno, Javier Valero, Belén Arias, Ignasi Miquel, Pilar Sánchez, Esther Rincón, Ramón López, Jesús Murat
Blood loss during grafting surgery represents a major concern of this procedure and the development of hemostatic agents for this indication is highly desirable. TT-173 is the first biologically active treatment based on tissue factor instead of thrombin. This study sought to investigate the efficacy, systemic absorption, and toxicology of TT-173 in animal models to support clinical evaluation of the product in donor sites of patients subjected to skin grafting. Procoagulant efficacy of 148 μg of TT-173 was evaluated in pigs in presence and absence of anticoagulant treatment with unfractioned heparin...
January 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28152550/novel-11%C3%AE-hydroxysteroid-dehydrogenase-1-inhibitors-reduce-cortisol-levels-in-keratinocytes-and-improve-dermal-collagen-content-in-human-ex-vivo-skin-after-exposure-to-cortisone-and-uv
#14
Stéphanie M Boudon, Anna Vuorinen, Piero Geotti-Bianchini, Eliane Wandeler, Denise V Kratschmar, Marc Heidl, Remo Campiche, Eileen Jackson, Alex Odermatt
Activity and selectivity assessment of new bi-aryl amide 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors, prepared in a modular manner via Suzuki cross-coupling, are described. Several compounds inhibiting 11β-HSD1 at nanomolar concentrations were identified. Compounds 2b, 3e, 7b and 12e were shown to selectively inhibit 11β-HSD1 over 11β-HSD2, 17β-HSD1 and 17β-HSD2. These inhibitors also potently inhibited 11β-HSD1 activity in intact HEK-293 cells expressing the recombinant enzyme and in intact primary human keratinocytes expressing endogenous 11β-HSD1...
2017: PloS One
https://www.readbyqxmd.com/read/28151863/miliary-tuberculosis-epidemiologicaland-clinical-analysis-of-large-case-series-from-moderate-to-low-tuberculosis-endemic-country
#15
Ali Mert, Ferhat Arslan, Tülin Kuyucu, Emine Nur Koç, Mesut Ylmaz, Demet Turan, Sedat Altn, Filiz Pehlivanoglu, Gonul Sengoz, Dilek Yldz, Ilyas Dokmetas, Suheyla Komur, Behice Kurtaran, Tuna Demirdal, Hüseyin A Erdem, Oguz Resat Sipahi, Ayse Batirel, Emine Parlak, Recep Tekin, Özlem Güzel Tunçcan, Ilker Inanc Balkan, Osman Hayran, Bahadr Ceylan
The aim of this study was to determine the clinical features, and outcome of the patients with miliary tuberculosis (TB).We retrospectively evaluated 263 patients (142 male, 121 female, mean age: 44 years, range: 16-89 years) with miliary TB. Criteria for the diagnosis of miliary TB were at least one of the followings in the presence of clinical presentation suggestive of miliary TB such as prolonged fever, night sweats, anorexia, weight loss: radiologic criterion and pathological criterion and/or microbiological criterion; pathological criterion and/or microbiological criterion...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28150367/open-label-randomized-multicenter-phase-iii-study-to-evaluate-the-safety-and-efficacy-of-benzoyl-peroxide-gel-in-long-term-use-in-patients-with-acne-vulgaris-a-secondary-publication
#16
Makoto Kawashima, Toshitaka Nagare, Tsuneo Katsuramaki
An open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (BPO) gels administrated once daily for 52 weeks to Japanese patients with acne vulgaris. The efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. In total, 458 subjects were included in the efficacy and safety analyses...
February 2, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28139006/comparison-of-protocols-measuring-diffusion-and-partition-coefficients-in-the-stratum-corneum
#17
H Rothe, C Obringer, J Manwaring, C Avci, W Wargniez, J Eilstein, N Hewitt, R Cubberley, H Duplan, D Lange, C Jacques-Jamin, M Klaric, A Schepky, S Grégoire
Partition (K) and diffusion (D) coefficients are important to measure for the modelling of skin penetration of chemicals through the stratum corneum (SC). We compared the feasibility of three protocols for the testing of 50 chemicals in our main studies, using three cosmetics-relevant model chemicals with a wide range of logP values. Protocol 1: SC concentration-depth profile using tape-stripping (measures KSC/v and DSC /HSC(2) , where HSC is the SC thickness); Protocol 2A: incubation of isolated SC with chemical (direct measurement of KSC/v only) and Protocol 2B: diffusion through isolated SC mounted on a Franz cell (measures KSC/v and DSC /HSC(2) , and is based on Fick's laws)...
January 31, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28133512/phototoxicity-evaluation-of-pharmaceutical-substances-with-a-reactive-oxygen-species-assay-using-ultraviolet-a
#18
Yong Sun Lee, Jung-Sun Yi, Hye Rim Lim, Tae Sung Kim, Il Young Ahn, Kyungyuk Ko, JooHwan Kim, Hye-Kyung Park, Soo Jung Sohn, Jong Kwon Lee
With ultraviolet and visible light exposure, some pharmaceutical substances applied systemically or topically may cause phototoxic skin irritation. The major factor in phototoxicity is the generation of reactive oxygen species (ROS) such as singlet oxygen and superoxide anion that cause oxidative damage to DNA, lipids and proteins. Thus, measuring the generation of ROS can predict the phototoxic potential of a given substance indirectly. For this reason, a standard ROS assay (ROS assay) was developed and validated and provides an alternative method for phototoxicity evaluation...
January 2017: Toxicological Research
https://www.readbyqxmd.com/read/28129815/-dalbavancin-breakpoints-and-recommendations-for-in-vitro-study-of-its-activity
#19
Rafael Cantón, María Díez-Aguilar, María Isabel Morosini
Dalbavancin is a semisynthetic lipoglycopeptide approved for the treatment of acute skin and soft tissue infections due to Gram-positive microorganisms susceptible to this antimicrobial agent. The FDA (Food and Drug Administration) and the EUCAST (European Committee on Antimicrobial Susceptibility Testing) have established clinical breakpoints to interpret the results of the antibiogram (expressed as MIC [minimum inhibitory concentration]) with approved doses (1g intravenously [IV] followed by 0.5g IV at day 8 or 1...
January 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28128470/factors-influencing-serum-concentrations-of-igd-in-the-adult-population-an-observational-study-in-spain
#20
Iago Carballo, Noelia Rabuñal, Lucía Alvela, Luis-Fernando Pérez, Carmen Vidal, Manuela Alonso, Bernardo Sopeña, Francisco Gude, Arturo Gonzalez-Quintela
Immunoglobulin D (IgD) is the least studied of immunoglobulin classes. This study sought to investigate the potential relationship between demographic, metabolic, lifestyle and immunologic factors, and serum IgD concentrations in a general adult population. We measured serum IgD concentrations by means of a commercial turbidimetric assay in 413 individuals (median age, 55 years; 45% males), randomly selected from the adult population of a Spanish municipality. Serum IgD concentrations displayed considerable variation in the population, ranging from undetectable (<6...
January 27, 2017: Scandinavian Journal of Immunology
keyword
keyword
3394
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"