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https://www.readbyqxmd.com/read/28326930/effects-of-jwh015-in-cytokine-secretion-in-primary-human-keratinocytes-and-fibroblasts-and-its-suitability-for-topical-transdermal-delivery
#1
Alicia Bort, Perla A Alvarado-Vazquez, Carolina Moracho-Vilrriales, Kristopher G Virga, Giuseppe Gumina, Alfonso Romero-Sandoval, Scott Asbill
Background JWH015 is a cannabinoid (CB) receptor type 2 agonist that produces immunomodulatory effects. Since skin cells play a key role in inflammatory conditions and tissue repair, we investigated the ability of JWH015 to promote an anti-inflammatory and pro-wound healing phenotype in human primary skin cells. Methods Human primary keratinocytes and fibroblasts were stimulated with lipopolysaccharide. The mRNA expression of cannabinoid receptors was determined using RT-PCR. The effects of JWH015 (0.05, 0...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28321359/high-throughput-screening-of-potential-skin-penetration-enhancers-using-stratum-corneum-lipid-liposomes-preliminary-evaluation-for-different-concentrations-of-ethanol
#2
Pajaree Sakdiset, Yuki Kitao, Hiroaki Todo, Kenji Sugibayashi
In this study, we developed a technique for high-throughput screening (HTS) of skin penetration-enhancers using stratum corneum lipid liposomes (SCLLs). A fluorescent marker, sodium fluorescein (FL), entrapped in SCLLs was prepared to provide a preliminary evaluation of the effect of different concentrations of ethanol on the disruption effect of SCLLs, which is an alternative for skin penetration-enhancing effects. In addition, SCLLs containing a fluorescent probe (DPH, TMA-DPH, or ANS) were also prepared and utilized to investigate SCLL fluidity...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28301407/in-vivo-cysteinyl-leukotriene-release-in-allergic-and-nonallergic-immediate-hypersensitivity-reactions-during-anesthesia
#3
Dominique Laroche, Pierre Léturgie, Delphine Mariotte, Yann Ollivier, Jean-Luc Hanouz, Brigitte Le Mauff, Jean-Jacques Parienti
BACKGROUND: Immediate hypersensitivity reactions occurring during anesthesia are classified as allergic when skin tests and mast cell tryptase are positive and as nonallergic when negative results are obtained. Cysteinyl leukotrienes (cysLTs) are potent mediators synthesized by mast cell and eosinophil that induce bronchial constriction. They could play a role in hypersensitivity reactions. METHODS: cysLT C4, D4, and E4 concentrations were measured by a competition immunoassay in serial plasma samples obtained prospectively from 21 anesthetized controls and retrospectively from 34 patients who reacted at induction of anesthesia (24 with allergic and 10 with nonallergic reactions)...
March 16, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28293107/nh4hco3-gas-generating-liposomal-nanoparticle-for-photoacoustic-imaging-in-breast-cancer
#4
Jizhu Xia, Gang Feng, Xiaorong Xia, Lan Hao, Zhigang Wang
In this study, we have developed a biodegradable nanomaterial for photoacoustic imaging (PAI). Its biodegradation products can be fully eliminated from a living organism. It is a gas-generating nanoparticle of liposome-encapsulating ammonium bicarbonate (NH4HCO3) solution, which is safe, effective, inexpensive, and free of side effects. When lasers irradiate these nanoparticles, NH4HCO3 decomposes to produce CO2, which can absorb much of the light energy under laser irradiation with a specific wavelength, and then expand under heat to generate a thermal acoustic wave...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28284688/evaluation-of-tilapia-skin-gelatin-as-a-mammalian-gelatin-replacer-in-acid-milk-gels-and-low-fat-stirred-yogurt
#5
Zhihua Pang, Hilton Deeth, Hongshun Yang, Sangeeta Prakash, Nidhi Bansal
Tilapia skin gelatin (TSG) was studied in a 3-stage process (cooling, annealing, and heating) for pure gelatin gels and in a 4-stage process (acidification, cooling, annealing, and heating) for acid milk gels and cultured yogurt. The aim was to evaluate the use of TSG as a replacement for mammalian gelatin in yogurt. In pure TSG gels, stronger gels with higher melting temperatures were formed with increasing TSG concentrations. Compared with bovine gelatin (BG), which gelled at a concentration of 2.5%, TSG gels had lower gelling (14...
March 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28283718/measuring-transdermal-glucose-levels-in-neonates-by-passive-diffusion-an-in-vitro-porcine-skin-model
#6
Cristina Tiangco, Abhay Andar, Juliana Quarterman, Xudong Ge, Fortunato Sevilla, Govind Rao, Audra Stinchcomb, Annette Bunge, Leah Tolosa
Current glucose monitoring techniques for neonates rely heavily on blood glucose monitors which require intermittent blood collection through skin-penetrating pricks on the heel or fingers. This procedure is painful and often not clinically conducive, which presents a need for a noninvasive method for monitoring glucose in neonates. Our motivation for this study was to develop an in vitro method for measuring passive diffusion of glucose in premature neonatal skin using a porcine skin model. Such a model will allow us to initially test new devices for noninvasive glucose monitoring without having to do in vivo testing of newborns...
March 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28283014/-fungemia-and-septic-arthritis-caused-by-saprochaete-capitata-in-a-patient-with-fanconi-aplastic-anemia-a-case-report
#7
Ömür Mustafa Parkan, Mustafa Altay Atalay, Ayşe Nedret Koç, Çiğdem Pala, Gonca Aydemir, Leylagül Kaynar
Saprochaete capitata (formerly known as Blastoschizomyces capitatus, Trichosporon capitatum, Geotrichum capitatum) is a rare but emerging yeast-like fungus. It is commonly found in environmental sources and can be isolated from skin, gastrointestinal system and respiratory tract of healthy individuals as well. It mainly infects patients with hematological malignancies such as acute myeloid leukemia (AML), especially in the presence of neutropenia; and mortality rates are high in those patients. Although the data about the in vitro antifungal susceptibility are limited, it is being reported that amphotericin B and voriconazole are more effective on S...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28277879/crude-4-methylcyclohexanemethanol-mchm-did-not-cause-skin-irritation-in-humans-in-48-h-patch-test
#8
Andrew D Monnot, Rachel M Novick, Dennis J Paustenbach
Crude 4-methylcyclohexanemethanol (MCHM) is an industrial chemical used to wash and clean coal. On January 9th, 2014 approximately 10,000 gallons of a mixture containing crude MCHM were released into the Elk River near Charleston, West Virginia, contaminating the local water supply. Following the spill, residents reported numerous health complaints, and sought medical attention for ailments including rashes and itching. The relationship between the complaints and the spill were unknown, as such symptoms are reported frequently in the background...
March 13, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28274658/effects-of-different-base-agents-on-prediction-of-skin-irritation-by-sodium-lauryl-sulfate-using-patch-testing-and-repeated-application-test
#9
Kotomi Horita, Daisuke Horita, Hiroyuki Tomita, Mitsue Yasoshima, Akiko Yagami, Kayoko Matsunaga
Animal testing for cosmetics was banned in the European Union (EU) in 2013; therefore, human tests to predict and ensure skin safety such as the patch test or usage test are now in demand in Japan as well as in the EU. In order to investigate the effects of different bases on the findings of tests to predict skin irritation, we performed patch testing (PT) and the repeated application test (RAT) using sodium lauryl sulfate (SLS), a well-known irritant, dissolved in 6 different base agents to examine the effects of these bases on skin irritation by SLS...
March 6, 2017: Toxicology
https://www.readbyqxmd.com/read/28272368/use-of-wearable-sensors-and-biometric-variables-in-an-artificial-pancreas-system
#10
Kamuran Turksoy, Colleen Monforti, Minsun Park, Garett Griffith, Laurie Quinn, Ali Cinar
An artificial pancreas (AP) computes the optimal insulin dose to be infused through an insulin pump in people with Type 1 Diabetes (T1D) based on information received from a continuous glucose monitoring (CGM) sensor. It has been recognized that exercise is a major challenge in the development of an AP system. The use of biometric physiological variables in an AP system may be beneficial for prevention of exercise-induced challenges and better glucose regulation. The goal of the present study is to find a correlation between biometric variables such as heart rate (HR), heat flux (HF), skin temperature (ST), near-body temperature (NBT), galvanic skin response (GSR), and energy expenditure (EE), 2D acceleration-mean of absolute difference (MAD) and changes in glucose concentrations during exercise via partial least squares (PLS) regression and variable importance in projection (VIP) in order to determine which variables would be most useful to include in a future artificial pancreas...
March 7, 2017: Sensors
https://www.readbyqxmd.com/read/28272075/the-impact-of-topical-saint-john-s-wort-hypericum-perforatum-treatment-on-tissue-tumor-necrosis-factor-alpha-levels-in-plaque-type-psoriasis-a-pilot-study
#11
P Mansouri, S Mirafzal, P Najafizadeh, Z Safaei-Naraghi, M H Salehi-Surmaghi, F Hashemian
CONTEXT: Psoriasis is an inflammatory disorder, formed by inappropriate interaction of T lymphocytes with keratinocytes, and consequent eruption of immune responses. High concentrations of tumor necrosis factor-alpha (TNFα) are found in the skin lesions and plasma of patients with psoriasis. Hypericum perforatum, a phytomedicine that has both anti-inflammatory and antiproliferative properties, has been recently reported to be clinically helpful for improvement of psoriatic lesions. AIMS: The aim of the present study was to investigate the effects of topical H...
March 3, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28263757/profile-differences-in-tetrodotoxin-transfer-to-skin-and-liver-in-the-pufferfish-takifugu-rubripes
#12
Ryohei Tatsuno, Wei Gao, Kotaro Ibi, Tomoka Mine, Kogen Okita, Gregory Naoki Nishihara, Tomohiro Takatani, Osamu Arakawa
Tetrodotoxin (TTX) was intramuscularly administered to nontoxic cultured specimens of the pufferfish Takifugu rubripes to investigate differences in the toxin transfer and accumulation profiles between the skin and liver. Test fish were administered TTX at doses of 30 (Low dose; LD), 100 (Medium dose; MD), and 300 (High dose; HD) μg/individual, respectively. Liquid chromatography/mass spectrometry analysis for TTX revealed that the TTX concentration in both the skin (0.48-1.7 μg/g) and liver (0.43-6.0 μg/g) at 24 h after the toxin administration increased with an increase in the dose...
March 2, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28263533/effects-of-therapeutic-formalin-bath-on-selected-indices-in-fish
#13
Livia Chmelova, Pavla Sehonova, Veronika Doubkova, Lucie Plhalova, Jana Blahova, Frantisek Tichy, Helena Modra, Zdenka Svobodova
OBJECTIVES: The aim of this study is to assess the effects of a treatment bath in a formalin solution on fish, focusing on haematological, biochemical and histopathological profiles. METHODS: A total of 96 common carps (Cyprinus carpio) were randomly assigned to eight groups. Four experimental groups were placed in the test solution for 60 minutes. The concentration of the formalin bath was 0.17 ml/l (38% formaldehyde), with the water temperature of 20°C. The effects of the bath were monitored immediately (E0) and 24 hours (E24h), 48 hours (E48h) and 10 days (E10d) after the bath...
December 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28250927/technical-and-clinical-validation-of-the-allergen-biocube-%C3%A2-for-timothy-grass
#14
Endri Angjeli, Paul Gomes, Keith J Lane, Linda Stein, Mark B Abelson
INTRODUCTION: Field studies for allergic rhinitis (AR) commonly have inconsistent allergen concentrations and subject exposure patterns due to varying environmental conditions and subject behaviors. A technical and clinical validation study was conducted for the Allergen BioCube(®) using timothy grass to confirm uniform allergen concentration and clinically relevant subject symptom responses. METHODS: Allergen concentrations were verified by laser particle counts...
March 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28250652/cosmeceutical-effects-of-galactomannan-fraction-from-arenga-pinnata-fruits-in-vitro
#15
Yanti, Madriena, Soegianto Ali
BACKGROUND: Cosmeceuticals refer to natural cosmetics with medical-like benefits due to their bioactive contents. Sugar palm fruit (Arenga pinnata) extract has been claimed for its anti-aging effect in vitro. However, its active compounds for cosmeceuticals is still unclear. OBJECTIVE: This study was aimed to extract galactomannan from A. pinnata fruits and test its efficacy for tyrosinase inhibition, antioxidant, and anti-photoaging activities in vitro. MATERIALS AND METHODS: Galactomannan from A...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28249553/occupational-exposure-and-respiratory-health-problems-among-nutmeg-production-workers-in-grenada-the-caribbean
#16
Muge Akpinar-Elci, Satesh Bidaisee, MyNgoc Thuy Nguyen, Omur Cinar Elci
BACKGROUND: The nutmeg industry is a major contributor to the Grenadian economy. However, workers in the industry face many environmental and occupational health risks. OBJECTIVES: The goal of this study was to investigate respiratory health problems and possible related occupational exposures among nutmeg production workers. METHODS: A questionnaire, spirometry and allergen skin-prick test was given to 92 nutmeg workers. Samples for measurement of airborne dust, mold, and phosphine were also collected from work environments...
March 2, 2017: International Journal of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28244771/risk-of-malnutrition-of-hospitalized-children-in-a-university-public-hospital
#17
Nelly Carolina Muñoz-Esparza, Edgar Manuel Vásquez-Garibay, Enrique Romero-Velarde, Rogelio Troyo-Sanromán
OBJECTIVE: The study aimed to demonstrate that the duration of hospitalization has a significant effect on the nutritional status of children treated in a university hospital. METHODS: A longitudinal study was conducted during 2014, with a non-random sampling site concentration in children from birth to 19 years who were admitted to the hospital in the past 24 hours and who met the inclusion criteria and had signed informed consent. Upon entering, at 7 days, and at discharge, anthropometric indices, including weight/age, height/age, weight/height, BMI/age, head circumference/age, triceps and subscapular skin folds, and fat percentage, were obtained...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28244128/a-quantitative-in-silico-model-for-predicting-skin-sensitization-using-a-nearest-neighbours-approach-within-expert-derived-structure-activity-alert-spaces
#18
Steven J Canipa, Martyn L Chilton, Rachel Hemingway, Donna S Macmillan, Alun Myden, Jeffrey P Plante, Rachael E Tennant, Jonathan D Vessey, Thomas Steger-Hartmann, Janet Gould, Jedd Hillegass, Sylvain Etter, Benjamin P C Smith, Angela White, Paul Sterchele, Ann De Smedt, Devin O'Brien, Rahul Parakhia
Dermal contact with chemicals may lead to an inflammatory reaction known as allergic contact dermatitis. Consequently, it is important to assess new and existing chemicals for their skin sensitizing potential and to mitigate exposure accordingly. There is an urgent need to develop quantitative non-animal methods to better predict the potency of potential sensitizers, driven largely by European Union (EU) Regulation 1223/2009, which forbids the use of animal tests for cosmetic ingredients sold in the EU. A Nearest Neighbours in silico model was developed using an in-house dataset of 1096 murine local lymph node (LLNA) studies...
February 28, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28243943/fluoride-alteration-of-3-h-glucose-uptake-in-wistar-rat-brain-and-peripheral-tissues
#19
Anna Rogalska, Katarzyna Kuter, Aleksandra Żelazko, Anna Głogowska-Gruszka, Elżbieta Świętochowska, Przemysław Nowak
The present study was designed to investigate the role of postnatal fluoride intake on [3H]glucose uptake and transport in rat brain and peripheral tissues. Sodium fluoride (NaF) in a concentration of 10 or 50 ppm was added to the drinking water of adult Wistar rats. The control group received distilled water. After 4 weeks, respective plasma fluoride levels were 0.0541 ± 0.0135 μg/ml (control), 0.0596 ± 0.0202 μg/ml (10 ppm), and 0.0823 ± 0.0199 μg/ml (50 ppm). Although plasma glucose levels were not altered in any group, the plasma insulin level in the fluoride (50 ppm) group was elevated (0...
April 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28242666/adjuvant-antibiotic-activity-of-acidic-sophorolipids-with-potential-for-facilitating-wound-healing
#20
Helen L Lydon, Niki Baccile, Breedge Callaghan, Roger Marchant, Christopher A Mitchell, Ibrahim M Banat
The sophorolipid class of biosurfactants are finding increasing use in personal care as well as pharmaceutical products and have the potential to disrupt biofilm formation and inhibit growth in a variety of clinically relevant organisms. In order to investigate potential biomedical applications of sophorolipids derived from non-pathogenic organisms, we fractionated and purified glycolipid biosurfactant sophorolipids produced by the yeast Starmerella bombicola, which yielded both acidic C 18-1 acetylated and non-acetylated congeners that were essentially free from other contaminants (>95% purity)...
February 27, 2017: Antimicrobial Agents and Chemotherapy
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