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https://www.readbyqxmd.com/read/28429598/preliminary-clinical-validation-of-a-differential-correction-method-for-improving-measurement-accuracy-in-noninvasive-measurement-of-blood-glucose-using-near-infrared-spectroscopy
#1
Guang Han, Xuyao Yu, Dandan Xia, Rong Liu, Jin Liu, Kexin Xu
One of the main challenges in the noninvasive sensing of blood glucose by near-infrared (NIR) spectroscopy is the background variations from light source drift, sweating, and temperature change at the human-machine interface. In this paper, a differential correction method based on the spectra from the floating-reference position and measuring position is proposed to eliminate these spectral variations from background interferences. Its effectiveness was validated by in vitro and in vivo experiments in which the diffuse reflectance of intralipid solutions and human skin was collected at the source distances of 0...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28427270/skin-irritation-testing-of-antimicrobial-conjugated-electrolytes
#2
Kristin N Wilde, Phuong A H Nguyen, David G Whitten, Heather E Canavan
Each year, the United States spends about $20 billion to treat people who have been infected with antibiotic resistant bacteria. Even so, the development of new antibiotics has slowed considerably since the mid-20th century. As a result, researchers are looking into developing synthetic compounds and materials with antimicrobial activities such as those made by the Schanze and Whitten groups [ACS Appl. Mater. Interfaces 3, 2820 (2011)]. Previously, they have demonstrated that poly(phenylene ethynylene) (PPE) based electrolytes and oligomeric end-only phenylene ethynylene (EO-OPE) based electrolytes possess strong biocidal activity...
April 20, 2017: Biointerphases
https://www.readbyqxmd.com/read/28427136/-effects-and-related-mechanism-of-bivalirudin-on-the-survival-of-random-skin-flap-on-the-back-of-rat
#3
L Y Cai, T Wang, D S Lin, D Lu
Objective: To investigate the effects and related mechanism of bivalirudin on the survival of random skin flap on the back of rat. Methods: Thirty SD rats were divided into bivalirudin group and normal saline group according to the random number table, with 15 rats in each group. The random flap model with size of 9 cm×3 cm was reproduced on the back of rats in two groups. Immediately post injury, rats in bivalirudin group were intraperitoneally injected with 5 mg/mL bivalirudin (0.8 mL/kg), while rats in normal saline group were intraperitoneally injected with normal saline (0...
April 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28422819/gnaq-tt-695-694-gc-polymorphism-is-associated-with-increased-gq-expression-vascular-reactivity-and-myocardial-injury-after-coronary-artery-bypass-surgery
#4
Ulrich H Frey, Stefanie Klenke, Anna Mitchell, Tim Knüfermann, Heinz Jakob, Matthias Thielmann, Winfried Siffert, Jürgen Peters
BACKGROUND: Angiotensin II receptor type 1-mediated activation of the α-subunit of the heterotrimeric Gq protein evokes increased vasoconstriction and may promote hypertrophy-induced myocardial damage. The authors recently identified a TT(-695/-694)GC polymorphism in the human Gq promoter, the GC allele being associated with an increased prevalence of cardiac hypertrophy. In this article, the authors tested whether the TT(-695/-694)GC polymorphism is associated with differences in (1) myocardial Gq protein expression, (2) vascular reactivity, and (3) myocardial damage after coronary artery bypass grafting...
April 19, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28420106/temporary-black-henna-tattoos-and-sensitization-to-para-phenylenediamine-ppd-two-paediatric-case-reports-and-a-review-of-the-literature
#5
Elisa Panfili, Susanna Esposito, Giuseppe Di Cara
Background: The use of temporary henna tattoos has increased dramatically in recent years, especially in children and adolescents. To obtain a darker colour and prolong the life of the tattoo, red henna, a plant-derived substance, is typically added to para-phenylenediamine (PPD). The mixture is called temporary black henna tattoo (TBHT). Because of its molecular characteristics, PPD can induce skin sensitization that may cause various clinical manifestations with successive exposures, among which the most common is allergic contact dermatitis (ACD)...
April 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28417624/cow-s-milk-desensitization-in-anaphylactic-patients-a-new-personalized-dose-method
#6
Delara Babaie, Mohammad Nabavi, Saba Arshi, Mehrnaz Mesdaghi, Zahra Chavoshzadeh, Mohammad Hasan Bemanian, Mitra Tafakori, Mehrdad Amirmoini, Hosein Esmailzadeh, Rasoul Molatefi, Mahsa Rekabi, Nadieh Akbarpour, Farimah Masoumi, Morteza Fallahpour
Cow's milk allergy (CMA) is the most frequent food allergy in children and oral immunotherapy (OIT) is a promising approach for treatment of patients. The most challenging cases are anaphylactic with coexisting asthma and proposing safe protocols is crucial especially in high risk groups. Considering that CMA varies among patients, an individualized OIT protocol would be beneficial to achieve a safer and more efficient method of desensitization. 18 children more than 3 years of age with IgE-mediated CMA were enrolled...
February 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28416643/can-serum-cytokine-profile-discriminate-irritant-induced-and-allergen-induced-symptoms-a-cross-sectional-study-in-workers-mostly-exposed-to-laboratory-animals
#7
Muriel Lemaire, Anne Oppliger, Philipp Hotz, Jean-Christophe Renauld, Julia Braun, Marion Maggi, Fabio Barresi, Peter Schmid-Grendelmeier, François Huaux, Holger Dressel
BACKGROUND: In workers exposed mostly to laboratory animals (LA), symptoms may be due to irritants or allergens. Correct aetiological diagnosis is important for health surveillance. OBJECTIVES: This study aims to test whether work-related (WR) allergen-induced symptoms are associated with a cytokine profile distinct from that due to irritants. METHODS: In a cross-sectional study (n=114), WR respiratory and/or skin symptoms were assessed through a standardised clinical examination and sensitisation to rat and/or mouse allergen determined by serum immunoglobulin E...
April 17, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28414146/tissue-distribution-of-a-therapeutic-monoclonal-antibody-determined-by-large-pore-microdialysis
#8
Satyawan B Jadhav, Vipada Khaowroongrueng, Matthias Fueth, Michael B Otteneder, Wolfgang Richter, Hartmut Derendorf
Therapeutic monoclonal antibodies (mAbs) exhibit limited distribution to the target tissues. Determination of target tissue interstitial concentration of mAbs is an important aspect in the assessment of their pharmacokinetic/pharmacodynamics (PK/PD) relationship especially for mAbs targeting membrane bound receptors. The pharmacokinetics of R7072, a full length mAb (IgG) targeting human insulin like growth factor-1 receptor (IGF-1R) was evaluated following a single intravenous (IV) dose at 1, 6.25 and 25 mg/kg in healthy female SCID-beige mice...
April 13, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28413507/anaphylactic-shock-caused-by-haemocoagulase-injection-in-china
#9
Haiwei Yang, Liming Yang, De-Wang Wang, Ji-Fu Wei, Shaoheng He
Haemocoagulase injection is a mixture of purified enzymes isolated from the venom of Bothrops atrox, which is used for the prevention and treatment of haemorrhage. It is a relatively safe pharmacological agent that does not require a skin test prior to administration. However, following a literature search, 14 reported cases of anaphylactic shock caused by haemocoagulase injection were identified, including one lethal case in China. Using SDS-PAGE and protein identification, four primary components in haemocoagulase injection were characterized, including one metalloproteinase, which may be a thromboplastin-like enzyme, and two serine proteinases, which may be thrombin-like enzymes...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28412574/work-place-drug-testing-of-police-officers-after-thc-exposure-during-large-volume-cannabis-seizures
#10
Gregory S Doran, Ralph Deans, Carlo De Filippis, Chris Kostakis, Julia A Howitt
Police officers responsible for the seizure and removal of illegally grown cannabis plants from indoor and outdoor growing operations face the prospect of THC exposure while performing their work duties. As a result, a study investigating the amount of THC on hands and uniforms of officers during raids on cannabis growing houses (CGHs) and forest cannabis plantations (FCPs) and in the air at these sites was conducted. Swabs of gloves/hands, chests, and heads/necks were collected and analysed for THC. Results of hand swabs indicated that officers removing plants from FCPs were exposed to THC concentrations up to 20 times those involved in raids at CGHs, which was mainly associated with the number and size of plants seized...
April 2, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28412568/first-report-on-mrsa-cc398-recovered-from-wild-boars-in-the-north-of-portugal-are-we-facing-a-problem
#11
Margarida Sousa, Nuno Silva, Vera Manageiro, Sónia Ramos, António Coelho, David Gonçalves, Manuela Caniça, Carmen Torres, Gilberto Igrejas, Patrícia Poeta
The aim of the present study was to evaluate the resistance of Staphylococcus aureus recovered from wild boars, to analyze their genetic lineages, and to investigate the susceptibility to oxacillin. Samples from mouth and nose of 45 wild boars (Sus scrofa) were collected during hunt activity from November 2012 to January 2013 in the North of Portugal. S. aureus isolates were recovered from 30 of these samples (33%); one isolate/sample was further studied. The susceptibility of the isolates was tested by disk-diffusion test against 14 antimicrobial agents and minimal inhibitory concentration was used to test oxacillin according to EUCAST guidelines...
April 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28412024/prevalence-of-bacterial-contamination-in-platelet-concentrates-at-the-national-center-of-blood-transfusion-mexico
#12
G Ibáñez-Cervantes, J M Bello-López, V Fernández-Sánchez, C A Domínguez-Mendoza, L I Acevedo-Alfaro
OBJECTIVES: Most common bacterial sepsis associated with transfusion is caused by contaminated Platelet Concentrates (PC). The screening of PC to detect bacterial contamination is obligatory in Mexico, and it is carried out in quality control programs. In Mexico, the identification and molecular characterization of bacterial contaminants to detect contamination sources have not been implemented due to high costs; however, it is an actual current need. MATERIAL AND METHODS: One hundred PC were randomly selected and microbiologically analyzed...
April 12, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28411127/preventing-false-negatives-in-the-in-vitro-skin-sensitization-testing-of-acid-anhydrides-using-interleukin-8-release-assays
#13
Kazuto Narita, Phuc Thi Hong Vo, Kenta Yamamoto, Hajime Kojima, Hiroshi Itagaki
In vitro safety tests may be used as replacements for animal tests owing to their accuracy and high-throughput performance. However, several in vitro skin sensitization tests produce false-negative results such as acid anhydride. Here, we investigated the relationship between false-negative results of acid anhydride and its hydrolysis by aqueous vehicle. Differences in the pattern of hydrolysis for phthalic anhydride (PAH) due to addition of 1 drop of stock solution of PAH in liquid paraffin (LP) dispersion medium and PAH in DMSO were analyzed in a cell-free system...
April 11, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28405912/continuous-transdermal-delivery-of-l-dopa-based-on-a-self-assembling-nanomicellar-system
#14
Amnon C Sintov, Haim V Levy, Igor Greenberg
PURPOSE: When levodopa (L-DOPA) is administered orally, it is eliminated from the body very quickly resulting in a series of sharp fluctuations in its blood concentrations. These frequent changes in blood levels are considered to be responsible for the development of late motor complications and dyskinesias, which are troubling clinical and treatment issues in Parkinson's disease. Transdermal drug delivery is a patient-compliant method for delivering therapeutics into the systemic circulation in a continuous and controlled manner...
April 12, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28403050/ceftaroline-activity-tested-against-bacterial-isolates-causing-community-acquired-respiratory-tract-infections-and-skin-and-skin-structure-infections-in-pediatric-patients-from-united-states-hospitals-2012-2014
#15
MULTICENTER STUDY
Michael A Pfaller, Rodrigo E Mendes, Mariana Castanheira, Robert K Flamm, Ronald N Jones, Helio S Sader
Ceftaroline fosamil has recently received US Food and Drug Administration approval for treatment of acute bacterial skin/skin structure infections (SSSIs), including those caused by methicillin-resistant Staphylococcus aureus and community-acquired bacterial pneumonia for pediatric patients ≥2 months old. We evaluated the potency and spectrum of ceftaroline and comparators when tested against community-acquired respiratory tract infection (CARTI) and SSSI pathogens from pediatric patients. A total of 3141 consecutive, unique pediatric patient isolates of clinical significance (1460 CARTI and 1681 SSSI isolates) were collected from 29 US medical centers and tested for susceptibility to ceftaroline and comparators by broth microdilution methods...
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28400730/biocompatible-colloidal-suspensions-based-on-magnetic-iron-oxide-nanoparticles-synthesis-characterization-and-toxicological-profile
#16
Dorina-Elena Coricovac, Elena-Alina Moacă, Iulia Pinzaru, Cosmin Cîtu, Codruta Soica, Ciprian-Valentin Mihali, Cornelia Păcurariu, Victor A Tutelyan, Aristidis Tsatsakis, Cristina-Adriana Dehelean
The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles as future theranostic tools for skin pathology and (ii) to test their effects in vitro on human keratinocytes (HaCat cells) and in vivo by employing an animal model of acute dermal toxicity. Biocompatible colloidal suspensions were obtained by coating the magnetic iron oxide nanoparticles resulted during the solution combustion synthesis with a double layer of oleic acid, as innovative procedure in increasing bioavailability...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28391487/ecotoxicological-evaluation-of-the-uv-filters-ethylhexyl-dimethyl-p-aminobenzoic-acid-and-octocrylene-using-marine-organisms-isochrysis-galbana-mytilus-galloprovincialis-and-paracentrotus-lividus
#17
A Giraldo, R Montes, R Rodil, J B Quintana, L Vidal-Liñán, R Beiras
The growing concern regarding the negative effects of solar radiation on the skin has led to a drastic increase in the use of sunscreens containing in its composition up to 10% of aromatic chemicals, such as ethylhexyl dimethyl p-aminobenzoic acid (OD-PABA) and octocrylene (OC). The objective of this study was to evaluate the toxicity and to assess the environmental risk posed by these two ultraviolet filters, widely used in cosmetics and as plastic additives, in the marine environment. Several ecotoxicological bioassays were performed with three model organisms belonging to different trophic levels: the microalgae Isochrysis galbana, the mussel Mytilus galloprovincialis, and the sea urchin Paracentrotus lividus...
April 8, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28378554/reference-values-and-utility-of-serum-total-immunoglobulin-e-for-predicting-atopy-and-allergic-diseases-in-korean-schoolchildren
#18
Hye Young Kim, Jaehee Choi, Kangmo Ahn, Myung Il Hahm, So Yeon Lee, Woo Kyung Kim, Yoomi Chae, Yong Mean Park, Man Yong Han, Kee Jae Lee, Ho Jang Kwon, Seonwoo Kim, Heejin Yoo, Jihyun Kim
The present study aimed to investigate the distribution of total serum immunoglobulin E (IgE) levels in Korean schoolchildren and to evaluate its utility in the prediction of atopy and allergic diseases. A nationwide, cross-sectional survey was conducted in first grade students from randomly selected elementary and middle schools. Total IgE levels were measured by ImmunoCAP. Skin prick tests were performed for 18 common inhalant allergens to determine the presence of atopy. Children aged 12-13 years and parents of children aged 6-7 years were asked to complete questionnaire assessing allergic diseases...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28370366/new-insights-on-the-antibacterial-efficacy-of-miconazole-in-vitro
#19
P Nenoff, D Koch, C Krüger, C Drechsel, P Mayser
Miconazole is a broad-spectrum antifungal used in topical preparations. In the present investigation the minimal inhibitory concentration (MIC) of miconazole for eighty wild type strains of gram-positive and gram-negative bacteria isolated from infected skin lesions was assessed using a modified agar dilution test (adapted to CLSI, Clinical Laboratory Standards Institute). 14 ATCC reference strains served as controls. Miconazole was found efficacious against gram-positive aerobic bacteria (n=62 species), the MICs against Staphylococcus (S...
March 30, 2017: Mycoses
https://www.readbyqxmd.com/read/28364408/comparison-of-the-efficacy-and-safety-of-pollen-allergen-extracts-using-skin-prick-testing-and-serum-specific-ige-as-references
#20
Nualanong Visitsunthorn, Kittipos Visitsuntho, Punchama Pacharn, Orathai Jirapongsananuruk, Chaweewan Bunnag
BACKGROUND: Allergen extracts may be different due to the difference in dissemination of allergen-containing species in various geographical areas. Therefore, we wish to develop our own extracts to ensure the precision and quality of diagnosis. OBJECTIVES: To compare the efficacy and safety of our locally prepared pollen allergen extracts to imported ones, using skin prick testing (SPT) and serum specific IgE (sIgE) as references. METHODS: This prospective, randomized, double-blinded, self-controlled study was performed in respiratory allergic adult volunteers who are sensitized to at least one kind of pollen...
April 1, 2017: Asian Pacific Journal of Allergy and Immunology
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