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https://www.readbyqxmd.com/read/28936806/simultaneous-application-of-cisplatin-and-static-magnetic-field-enhances-oxidative-stress-in-hela-cell-line
#1
Samaneh Kamalipooya, Parviz Abdolmaleki, Zahra Salemi, Fatemeh Javani Jouni, Jaber Zafari, Homa Soleimani
In this study, we reported the effects of simultaneous application of static magnetic field (SMF) and cisplatin as an anticancer drug on the oxidative stress in human cervical cancer (HeLa) cell line and normal skin fibroblast cells (Hu02). The cells were exposed to different SMF intensities (7, 10, and 15 mT) for 24 and 48 h. IC50 concentrations of cisplatin were obtained by MTT assay. The cytotoxic effects of combined treatment were studied by measuring the intracellular reactive oxygen species content using flow cytometric method and estimation of membrane lipid peroxidation by spectrophotometry...
September 21, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28927888/the-effect-of-water-hardness-on-surfactant-deposition-following-washing-and-subsequent-skin-irritation-in-atopic-dermatitis-patients-and-healthy-controls
#2
Simon G Danby, Kirsty Brown, Andrew M Wigley, John Chittock, Phyoe K Pyae, Carsten Flohr, Michael J Cork
Living in a hard water area is associated with an increased risk of atopic dermatitis (AD). Greater skin barrier impairment following exposure to surfactants in wash products combined with high calcium, and/or chlorine, levels in hard water is a compelling mechanism for this increase. The purpose of this study was to investigate this mechanism in individuals with and without a predisposition to skin barrier impairment. We recruited 80 subjects; healthy controls and AD patients with and without FLG mutations...
September 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28925684/carbon-nanotube-based-ion-selective-sensors-for-wearable-applications
#3
Soumyendu Roy, Moshe David-Pur, Yael Hanein
Wearable electronics offer new opportunities in a wide range of applications, especially sweat analysis using skin sensors. A fundamental challenge in these applications is the formation of sensitive and stable electrodes. In this article we report the development of a wearable sensor based on carbon nanotube (CNT) electrode arrays for sweat sensing. Solid-state ion selective electrodes (ISEs), sensitive to Na+ ions, were prepared by drop coating plasticized poly-vinyl chloride (PVC) doped with ionophore and ion exchanger on CNT electrodes...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28924447/passive-blood-anaphylaxis-subcutaneous-immunoglobulins-are-a-cause-of-ongoing-passive-anaphylactic-reaction
#4
Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda, Agnieszka Korzeniowska-Kowal
BACKGROUND: Allergic, especially anaphylactic, reactions during immunoglobulin replacement therapy are rare, but their pathophysiology and classification remain ambiguous. Recent findings show positive results of skin tests with commercially available immunoglobulins, but target antigens and responsible compounds of the tested immunoglobulins have not been strictly identified. CASE DESCRIPTION AND FINDINGS: Four adult patients with recently diagnosed common variable immunodeficiency qualified for standard subcutaneous immunoglobulin replacement therapy regimen...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28916377/clinical-and-molecular-characterization-of-two-chinese-patients-with-type-2-congenital-generalized-lipodystrophy
#5
Ruimin Chen, Xin Yuan, Jian Wang, Ying Zhang
BACKGROUND: Type 2 congenital generalized lipodystrophy (CGL2, OMIM 269700) is a rare autosomal recessive disease, characterized by the generalized absence of adipose tissue at birth or in early infancy. Pathogenic variants in BSCL2 gene have been reported to be responsible for CGL2. The aim of this study is to analyze the clinical and genetic characteristics of two Chinese patients with CGL2, and with particular focus on the BSCL2 gene sequence variants. METHODS: Medical history, clinical manifestations, physical examination, laboratory data, and ultrasonography findings were analyzed for the two patients with CGL2...
September 12, 2017: Gene
https://www.readbyqxmd.com/read/28915118/delayed-diagnosis-of-proopiomelanocortin-pomc-deficiency-with-type-1-diabetes-in-a-9-year-old-girl-and-her-infant-sibling
#6
Elif Ozsu, Allison Bahm
BACKGROUND: Proopiomelanocortin (POMC) protein, encoded by the POMC gene, is the precursor of adrenocorticotropic hormone (ACTH) that is released from the anterior pituitary gland. Homozygous mutations in the POMC gene is associated with hyperphagia, severe and early-onset obesity, adrenal insufficiency, hypopigmentation of the skin and red hair. CASE PRESENTATION: A 9-year-old girl from a consanguineous family of Iraqi origin was diagnosed with type 1 diabetes...
September 15, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28913990/association-between-sensitization-to-mold-and-impaired-pulmonary-function-in-children-with-asthma
#7
Jung Hye Byeon, Soohyun Ri, Oyuntulga Amarsaikhan, Eunji Kim, So Hyun Ahn, Ic Sun Choi, Hyung Jin Kim, SungChul Seo, Wonsuck Yoon, Young Yoo
PURPOSE: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. In this study, we investigated the relationships between sensitization to mold and lung function parameters in children with asthma. METHODS: We retrospectively reviewed clinical data from 551 asthmatic subjects. We selected subjects who met clinical diagnostic criteria of asthma. Their spirometry, methacholine challenge tests, and measurements of blood eosinophils, serum IgE, eosinophil cationic protein (ECP) and fractional exhaled nitric oxide (FeNO) results were included...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28905380/enhancing-blood-donor-skin-disinfection-using-natural-oils
#8
Meshari Alabdullatif, Imen Boujezza, Mohamed Mekni, Mariam Taha, Dilini Kumaran, Qi-Long Yi, Ahmed Landoulsi, Sandra Ramirez-Arcos
BACKGROUND: Effective donor skin disinfection is essential in preventing bacterial contamination of blood components with skin flora bacteria like Staphylococcus epidermidis. Cell aggregates of S. epidermidis (biofilms) are found on the skin and are resistant to the commonly used donor skin disinfectants chlorhexidine-gluconate and isopropyl alcohol. It has been demonstrated that essential oils synergistically enhance the antibacterial activity of chlorhexidine-gluconate. The objective of this study was to test plant-extracted essential oils in combination with chlorhexidine-gluconate or chlorhexidine-gluconate plus isopropyl alcohol for their ability to eliminate S...
September 14, 2017: Transfusion
https://www.readbyqxmd.com/read/28899692/in-vitro-efficacy-of-bumped-kinase-inhibitors-against-besnoitia-besnoiti-tachyzoites
#9
Alejandro Jiménez-Meléndez, Kayode K Ojo, Alexandra M Wallace, Tess R Smith, Andrew Hemphill, Vreni Balmer, Javier Regidor-Cerrillo, Luis M Ortega-Mora, Adrian B Hehl, Erkang Fan, Dustin J Maly, Wesley C Van Voorhis, Gema Álvarez-García
Besnoitia besnoiti is an apicomplexan parasite responsible for bovine besnoitiosis, a chronic and debilitating disease that causes systemic and skin manifestations and sterility in bulls. Neither treatments nor vaccines are currently available. In the search for therapeutic candidates, calcium-dependent protein kinases have arisen as promising drug targets in other apicomplexans (e.g. Neospora caninum, Toxoplasma gondii, Plasmodium spp. and Eimeria spp.) and are effectively targeted by bumped kinase inhibitors...
September 9, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28888846/diagnostic-accuracy-of-urinary-lte4-measurement-to-predict-aspirin-exacerbated-respiratory-disease-in-patients-with-asthma
#10
Grazyna Bochenek, Tomasz Stachura, Krystyna Szafraniec, Hanna Plutecka, Marek Sanak, Ewa Nizankowska-Mogilnicka, Krzysztof Sladek
BACKGROUND: Patients with aspirin-exacerbated respiratory disease (AERD) are distinguished from patients with aspirin-tolerant asthma (ATA) by significantly higher baseline concentrations of urinary leukotriene E4 (uLTE4). However, an overlap between the individual values of the groups exists. OBJECTIVE: The objective of this study was to estimate the discriminative value of uLTE4 concentration in differentiating between patients with AERD and patients with ATA and evaluate the diagnostic accuracy of uLTE4 measurement alone and added to clinical parameters to predict AERD diagnosis in patients with asthma...
September 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28884475/chronic-exposure-of-interleukin-13-suppress-the-induction-of-matrix-metalloproteinase-1-by-tumor-necrosis-factor-%C3%AE-in-normal-and-scleroderma-dermal-fibroblasts-through-protein-kinase-b-akt
#11
Monica L Brown Lobbins, Bangalore R Shivakumar, Arnold E Postlethwaite, Karen A Hasty
OBJECTIVE: Peripheral blood mononuclear cells taken from patients with scleroderma express increased levels of IL-13. Moreover, the expression of MMP-1 from involved scleroderma skin fibroblasts is refractory to stimulation by tumor necrosis factor alpha. To elucidate the mechanism(s) involved, we examined the effect of IL-13 on TNF-α-induced matrix metalloproteinase-1 expression in normal and scleroderma human dermal fibroblast lines and studied the involvement of serine/threonine kinase B/Akt in this response...
September 7, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28882705/prediction-of-skin-sensitization-potency-sub-categories-using-peptide-reactivity-data
#12
Britta Wareing, Daniel Urbisch, Susanne Noreen Kolle, Naveed Honarvar, Ursula G Sauer, Annette Mehling, Robert Landsiedel
While the skin sensitization hazard of substances can already be identified using non-animal methods, the classification of potency sub-categories GHS-1A and 1B is still challenging. Potency can be measured by the dose at which an effect is observed; since the protein-adduct formation is determining the dose of the allergen in the skin, peptide reactivity was used to assess the potency. The Direct Peptide Reactivity Assay (DPRA; one concentration and reaction-time) did not sufficiently discriminate between sub-categories 1A and 1B (56% accuracy compared to LLNA data, n=124)...
September 4, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28877539/liquid-and-vapor-phase-activity-of-artemisia-annua-essential-oil-against-pathogenic-malassezia-spp
#13
Francesca Santomauro, Rosa Donato, Gabriella Pini, Cristiana Sacco, Roberta Ascrizzi, Anna Rita Bilia
Artemisia annua essential oil has given us many encouraging results for its numerous antimicrobial properties. In this study, the essential oil, both in liquid and in vapor phases, was tested against various Malassezia species closely related to many skin disorders in humans and animals. Malassezia treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance, and several side effects. Monoterpenes (ca. 88%) represent the most abundant group of compounds in the essential oil, mainly the oxygenated derivatives (ca...
September 6, 2017: Planta Medica
https://www.readbyqxmd.com/read/28859262/increased-levels-of-inflammatory-proteins-typify-the-earliest-phase-of-systemic-sclerosis
#14
Marta Cossu, Lenny van Bon, Carlo Preti, Marzia Rossato, Lorenzo Beretta, Timothy R D J Radstake
OBJECTIVE: Definite systemic sclerosis patients lacking fibrotic features stratify in an intermediate severity stage between preclinical/early (EaSSc) and fibrotic subsets (limited and diffuse cutaneous [lcSSc, dcSSc]). We aimed to molecularly characterize non-fibrotic SSc and EaSSc on the basis of a broad panel of serum markers of inflammation and tissue damage to increase the knowledge of pathophysiologic mechanisms underlying SSc progression before development of fibrosis. METHODS: An 88-plex immunoassay was performed in sera from a discovery cohort composed of 21 EaSSc (LeRoy and Medsger criteria), 15 non-fibrotic SSc (2013 ACR/EULAR criteria without skin or lung fibrosis) and 11 HC...
August 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28858130/effect-of-bispectral-index-guided-anesthesia-on-consumption-of-anesthetics-and-early-postoperative-cognitive-dysfunction-after-liver-transplantation-an-observational-study
#15
Ying-Hao Cao, Ping Chi, Yan-Xing Zhao, Xi-Chen Dong
The objective of this study was to summarize the incidence of postoperative cognitive dysfunction (POCD) after 7days following liver transplantation (LT), and to evaluate the effectiveness of bispectral index (BIS) guided anesthetic intervention in reducing POCD. Additional serum concentrations of S100β and neuron-specific enolase (NSE) were detected during surgery to determine whether they were reliable predictors of POCD.Patients who underwent LT at Beijing YouAn Hospital Affiliated to Capital University of Medical Science from January 2014 to December 2015 were enrolled...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28856141/diagnosis-and-treatment-of-pulmonary-cavity-after-liver-transplantation
#16
Yongxiang Xia, Haoming Zhou, Feipeng Zhu, Wei Zhang, Chen Wu, Ling Lu
BACKGROUND: Although the outcomes have improved in the current era, pulmonary infection remains a significant post-transplant complication in liver transplant (LT) recipients. Pulmonary infection with cavity formation often leads to higher mortality rates after LT. We wished to investigate the diagnosis and treatment of pulmonary cavity (PC) formation after LT. METHODS: We evaluated (retrospectively) five cases of PC formation, shown on CT scans of the chest after LT, by analyzing imaging features, diagnosis, treatment, liver function, and the concentration changes and efficacy of immunosuppressants...
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28851585/development-of-a-sensitive-generic-and-easy-to-use-organophosphate-skin-disclosure-kit
#17
Franz Worek, Andreas Wosar, Madlen Baumann, Horst Thiermann, Timo Wille
Various organophosphorus compounds (OP), primarily the nerve agent VX and other V-agents, are highly toxic to humans after skin exposure. Percutaneous exposure by such OP results in a delayed onset of toxic signs which enables the initiation of specific countermeasures if contamination is detected rapidly. Presently available mobile detection systems can hardly detect skin exposure by low volatile OP. In order to fill this gap an OP skin disclosure kit was developed which should fulfill different requirements, i...
August 26, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28845027/dibutyl-phthalate-rather-than-monobutyl-phthalate-facilitates-contact-hypersensitivity-to-fluorescein-isothiocyanate-in-a-mouse-model
#18
Kohta Kurohane, Kota Sekiguchi, Erina Ogawa, Masato Tsutsumi, Yasuyuki Imai
Dibutyl phthalate (DBP) is a plasticizer used for many consumer products including cosmetics. Potential health concerns regarding DBP include reproductive and developmental toxicity, endocrine disruption and neurotoxicity. DBP is a high priority chemical as to reduction of exposure of children to it. Through reproductive toxicity studies, monobutyl phthalate (MBP) has been proposed to be the active metabolite derived from DBP. We previously demonstrated that DBP activates transient receptor potential ankyrin 1 (TRPA1) cation channels expressed on sensory neurons...
August 26, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28835358/combined-action-of-human-commensal-bacteria-and-amorphous-silica-nanoparticles-on-the-viability-and-immune-responses-of-dendritic-cells
#19
Giulia Malachin, Elisa Lubian, Fabrizio Mancin, Emanuele Papini, Regina Tavano
Dendritic cells (DCs) regulate the host-microbe balance in gut and skin, tissues likely exposed to nanoparticles (NPs) present in drugs, food and cosmetics. We analysed the viability and the activation of DCs incubated with extracellular media (EMs) obtained from cultures of commensal (E. coli, S. epidermidis) or pathogenic (P. aeruginosa, S. aureus) bacteria, in the presence of amorphous silica nanoparticles (SiO2-NPs). EMs synergised cytotoxicity and cytokines production with different nanoparticle dose-response characteristics, depending on the bacterial species...
August 23, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28834724/omecamtiv-mecarbil-abolishes-length-mediated-increase-in-guinea-pig-cardiac-myofiber-ca-2-sensitivity
#20
Sampath K Gollapudi, Sherif M Reda, Murali Chandra
Omecamtiv mecarbil (OM) is a pharmacological agent that augments cardiac contractile function by enhancing myofilament Ca(2+) sensitivity. Given that interventions that increase myofilament Ca(2+) sensitivity have the potential to alter length-dependent activation (LDA) of cardiac myofilaments, we tested the influence of OM on this fundamental property of the heart. This is significant not only because LDA is prominent in cardiac muscle but also because it contributes to the Frank-Starling law, a mechanism by which the heart increases stroke volume in response to an increase in venous return...
August 22, 2017: Biophysical Journal
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