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Vanja lazarevic

B Heidi Ellis, Saida M Abdi, Vanja Lazarevic, Matthew T White, Alisa K Lincoln, Jessica E Stern, John G Horgan
Refugee studies have examined both resilience and adverse outcomes, but no research has examined how different outcomes co-occur or are distinct, and the social-contextual factors that give rise to these diverse outcomes. The current study begins to address this gap by using latent profile analysis to examine the ways in which delinquency, gang involvement, civic engagement, political engagement, and openness to violent extremism cluster among Somali refugees. We then use multivariable regression analyses to examine how adversity (e...
2016: American Journal of Orthopsychiatry
Stanley Adoro, Juan R Cubillos-Ruiz, Xi Chen, Maud Deruaz, Vladimir D Vrbanac, Minkyung Song, Suna Park, Thomas T Murooka, Timothy E Dudek, Andrew D Luster, Andrew M Tager, Hendrik Streeck, Brittany Bowman, Bruce D Walker, Douglas S Kwon, Vanja Lazarevic, Laurie H Glimcher
Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, it is not known whether interleukin-21 (IL-21) contributes to early HIV-1 immunity. Here we take advantage of tractable primary human lymphoid organ aggregate cultures to show that IL-21 directly suppresses HIV-1 replication, and identify microRNA-29 (miR-29) as an antiviral factor induced by IL-21 in CD4 T cells...
2015: Nature Communications
Alisa K Lincoln, Vanja Lazarevic, Matthew T White, B Heidi Ellis
Refugee adolescents often immigrate to a new society because of experiences of persecution and trauma, which can have profound effects on their mental health. Once they immigrate, many refugees experience stressors related to resettlement and acculturation in the new society. The current study examined relationships among acculturation styles and hassles and the well-being of young refugees as well as the role of gender. Data were collected from 135 young refugees (M age = 15.39, SD = 2.2; 62 % male) from Somalia resettled in the United States The findings from our study indicate that in addition to trauma history, acculturative hassles and acculturation style impact the wellbeing of Somali refugee adolescents...
August 2016: Journal of Immigrant and Minority Health
Brandon Kwong, Vanja Lazarevic
Very little is known about the transcription factor network that regulates the development of intestinal intraepithelial lymphocytes (IELs). In this issue of Immunity, Klose et al. (2014b) and Reis et al. (2014) demonstrate an essential role for T-bet in regulating the CD8αα IEL differentiation program.
August 21, 2014: Immunity
Changwan Hong, Megan A Luckey, Davinna L Ligons, Adam T Waickman, Joo-Young Park, Grace Y Kim, Hilary R Keller, Ruth Etzensperger, Xuguang Tai, Vanja Lazarevic, Lionel Feigenbaum, Marta Catalfamo, Scott T R Walsh, Jung-Hyun Park
The common γ-chain (γc) plays a central role in signaling by IL-2 and other γc-dependent cytokines. Here we report that activated T cells produce an alternatively spliced form of γc mRNA that results in protein expression and secretion of the γc extracellular domain. The soluble form of γc (sγc) is present in serum and directly binds to IL-2Rβ and IL-7Rα proteins on T cells to inhibit cytokine signaling and promote inflammation. sγc suppressed IL-7 signaling to impair naive T cell survival during homeostasis and exacerbated Th17-cell-mediated inflammation by inhibiting IL-2 signaling upon T cell activation...
June 19, 2014: Immunity
Yan Wang, Jernej Godec, Khadija Ben-Aissa, Kairong Cui, Keji Zhao, Alexandra B Pucsek, Yun Kyung Lee, Casey T Weaver, Ryoji Yagi, Vanja Lazarevic
T helper 17 (Th17) cells can give rise to interleukin-17A (IL-17A)- and interferon (IFN)-γ-double-producing cells that are implicated in development of autoimmune diseases. However, the molecular mechanisms that govern generation of IFN-γ-producing Th17 cells are unclear. We found that coexpression of the Th1 and Th17 cell master transcription factors, T-bet and retinoid-related orphan receptor gamma-t (RORγt), respectively, did not generate Th cells with robust IL-17 and IFN-γ expression. Instead, development of IFN-γ-producing Th17 cells required T-bet and Runx1 or Runx3...
March 20, 2014: Immunity
Jennifer A Kam, Vanja Lazarevic
Language brokering remains prevalent among immigrant families, but it is widely assumed that brokering functions as a cultural stressor, resulting in adverse health outcomes for immigrant youth. Few studies, however, have tested this assumption, particularly while using longitudinal data and capturing multiple dimensions of brokering. Thus, this study examined how depressive symptoms and family-based acculturation stress mediated the relationships between various aspects of brokering (i.e., frequency of brokering, positive and negative feelings about brokering, brokering norms, and brokering efficacy) and alcohol, cigarette, and marijuana use and other risky behaviors...
December 2014: Journal of Youth and Adolescence
Vanja Lazarevic, Laurie H Glimcher, Graham M Lord
Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet has a fundamental role in coordinating type 1 immune responses by controlling a network of genetic programmes that regulate the development of certain immune cells and the effector functions of others. Many of these transcriptional networks are conserved across innate and adaptive immune cells and these shared mechanisms highlight the biological functions that are regulated by T-bet...
November 2013: Nature Reviews. Immunology
Marc N Wein, Dallas C Jones, Jae-Hyuck Shim, Antonios O Aliprantis, Rosalyn Sulyanto, Vanja Lazarevic, Sandra L Poliachik, Ted S Gross, Laurie H Glimcher
Mice lacking the large zinc finger protein Schnurri-3 (Shn3) display increased bone mass, in part, attributable to augmented osteoblastic bone formation. Here, we show that in addition to regulating bone formation, Shn3 indirectly controls bone resorption by osteoclasts in vivo. Although Shn3 plays no cell-intrinsic role in osteoclasts, Shn3-deficient animals show decreased serum markers of bone turnover. Mesenchymal cells lacking Shn3 are defective in promoting osteoclastogenesis in response to selective stimuli, likely attributable to reduced expression of the key osteoclastogenic factor receptor activator of nuclear factor-κB ligand...
May 22, 2012: Proceedings of the National Academy of Sciences of the United States of America
Ljubica Djukanović, Biserka Aksić-Miličević, Miodrag Antić, Jovan Baković, Željko Varga, Biljana Gojaković, Nada Dimković, Verica Đorđević, Vidojko Đorđević, Stevan Đurić, Sunčica Đurić, Nenad Zec, Rosa Jelačić, Zoran Kovačević, Tatjana Lazarević, Višnja Ležaić, Milan Mandić, Ivko Marić, Srboljub Milenković, Olivera Milićević, Milena Mišković, Igor Mitić, Zora Nikolić, Draga Pilipović, Stevo Plješa, Miroslava Radaković, Nenad Rakić, Vanja Rangelov, Radivoje Stojanović, Marina Stojanović-Stanojević, Biserka Tirmenštajn-Janković, Branimir Haviža-Lilić, Edvin Hadžibulić, Rajko Hrvačević, Anica Cvetičanin
The study presents the epidemiological features of patients treated with renal replacement therapy (RRT) in Serbia from 1997 to 2009 and compares the results of hemodialysis treatment in 1999 and 2009. Epidemiological data were obtained from the National Registry of RRT patients and data on hemodialysis treatment from special surveys conducted in 1999 and 2009. Within the period 1997-2009 the incidence of patients on RRT increased from 108 to 179 per million population (pmp), prevalence rose from 435 to 699 pmp, while mortality rate fell from 20...
October 2012: Hemodialysis International
Vanja Lazarevic, Laurie H Glimcher
The activation of immune-defense mechanisms in response to a microbial attack must be robust and appropriately tailored to fight particular types of pathogens. Infection with intracellular microorganisms elicits a type 1 inflammatory response characterized by mobilization of T helper type 1 (T(H)1) cells to the site of infection, where they are responsible for the recruitment and activation of macrophages. At the center of the type 1 inflammatory response is the transcription factor T-bet, a critical regulator of the T(H)1 differentiation program...
July 2011: Nature Immunology
Tracy L Staton, Vanja Lazarevic, Dallas C Jones, Amanda J Lanser, Tsuyoshi Takagi, Shunsuke Ishii, Laurie H Glimcher
Generation of a diverse and self-tolerant T-cell repertoire requires appropriate interpretation of T-cell antigen receptor (TCR) signals by CD4(+ ) CD8(+) double-positive thymocytes. Thymocyte cell fate is dictated by the nature of TCR-major-histocompatibility-complex (MHC)-peptide interactions, with signals of higher strength leading to death (negative selection) and signals of intermediate strength leading to differentiation (positive selection). Molecules that regulate T-cell development by modulating TCR signal strength have been described but components that specifically define the boundaries between positive and negative selection remain unknown...
April 7, 2011: Nature
Vanja Lazarevic, Xi Chen, Jae-Hyuck Shim, Eun-Sook Hwang, Eunjung Jang, Alexandra N Bolm, Mohamed Oukka, Vijay K Kuchroo, Laurie H Glimcher
Overactive responses by interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) are tightly linked to the development of autoimmunity, yet the factors that negatively regulate the differentiation of this lineage remain unknown. Here we report that the transcription factor T-bet suppressed development of the T(H)17 cell lineage by inhibiting transcription of Rorc (which encodes the transcription factor RORγt). T-bet interacted with the transcription factor Runx1, and this interaction blocked Runx1-mediated transactivation of Rorc...
January 2011: Nature Immunology
Lorena Riol-Blanco, Vanja Lazarevic, Amit Awasthi, Meike Mitsdoerffer, Brian S Wilson, Andy Croxford, Ari Waisman, Vijay K Kuchroo, Laurie H Glimcher, Mohamed Oukka
IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established the essential role of IL-23R in the host response against intracellular pathogens. IL-23 was critical for the expansion or maintenance of gammadelta and double negative (DN) alphabeta T cells. These cells were rapidly recruited to the site of infection and produced large amounts of IL-17, IFN-gamma, and TNF-alpha...
February 15, 2010: Journal of Immunology: Official Journal of the American Association of Immunologists
Vanja Lazarevic, Alfred J Zullo, Michelle N Schweitzer, Tracy L Staton, Elena M Gallo, Gerald R Crabtree, Laurie H Glimcher
The influence of signals transmitted by the phosphatase calcineurin and the transcription factor NFAT on the development and function of natural killer T (NKT) cells is unclear. In this report, we demonstrate that the transcription factor early growth response 2 (Egr2), a target gene of NFAT, was specifically required for the ontogeny of NKT cells but not that of conventional CD4(+) or CD8(+) T cells. NKT cells developed normally in the absence of Egr1 or Egr3, which suggests that Egr2 is a specific regulator of NKT cell differentiation...
March 2009: Nature Immunology
Vanja Lazarevic, Fabio Martinon
One-third of the world's population is infected with Mycobacterium tuberculosis, one of the most effective human pathogens, whose success is attributed to the deployment of remarkably sophisticated immune evasion mechanisms. In this issue of Cell Host & Microbe, a new study unravels a novel strategy of immune evasion and enhanced bacterial intracellular survival, which is dependent on inhibition of inflammasome activation by an M. tuberculosis-encoded metalloprotease.
April 17, 2008: Cell Host & Microbe
Brandon M Sullivan, Ousman Jobe, Vanja Lazarevic, Kristine Vasquez, Roderick Bronson, Laurie H Glimcher, Igor Kramnik
A sustained CD4+ Th1-dominated type 1 immune response is required to successfully control Mycobacterium tuberculosis infection. Considerable work has demonstrated that the transcription factor, T-bet, is required for IFN-gamma expression and fundamental to the generation of type 1 immunity in multiple cell types. Mice lacking T-bet are susceptible to virulent M. tuberculosis infection. Susceptibility of T-bet-deficient mice is associated with increased systemic bacterial burden, diminished IFN-gamma production, and the striking accumulation of eosinophilic macrophages and multinucleated giant cells in the lung...
October 1, 2005: Journal of Immunology: Official Journal of the American Association of Immunologists
Vanja Lazarevic, Dawn Nolt, JoAnne L Flynn
The primary goal of this study was to determine how chronic exposure to Ag influences the functionality of Mycobacterium tuberculosis-specific T cell responses. The frequency of IFN-gamma-producing effector CD4(+) and CD8(+) T cells dynamically changed during persistent M. tuberculosis infection. CD8(+) T cells used differential effector functions during acute and chronic phases of the immune response, where CD8(+) T cells produced negligible amounts of IFN-gamma early in infection, but switched to cytokine production during the chronic stage of infection...
July 15, 2005: Journal of Immunology: Official Journal of the American Association of Immunologists
Vanja Lazarevic, Santosh Pawar, Joanne Flynn
Enzyme-linked immunospot (ELISPOT) was originally developed from an enzyme-linked immunosorbent assay (ELISA) to detect and measure the frequency of individual cells that produce cytokines in response to antigenic stimulation. ELISPOT assay is more sensitive than the enzyme-linked immunosorbent assay or intracellular cytokine staining. Increased sensitivity of ELISPOT is particularly advantageous when studying T-cell-mediated responses in Mycobacterium tuberculosis infection because antigen specific T-cells can occur at a low frequency in vivo...
2005: Methods in Molecular Biology
Vanja Lazarevic, David J Yankura, Sherrie J DiVito, JoAnne L Flynn
Several studies have provided evidence that interleukin-15 (IL-15) can enhance protective immune responses against Mycobacterium tuberculosis infection. However, the effects of IL-15 deficiency on the functionality of M. tuberculosis-specific CD4 and CD8 T cells are unknown. In this study, we investigated the generation and maintenance of effector and memory T-cell responses following M. tuberculosis infection of IL-15(-/-) mice. IL-15(-/-) mice had slightly higher bacterial numbers during chronic infection, which were accompanied by an increase in gamma interferon (IFN-gamma)-producing CD4 and CD8 T cells...
May 2005: Infection and Immunity
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