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JOURNAL ARTICLE
Mohammad Arifuzzaman, Tae Hyung Won, Hiroshi Yano, Jazib Uddin, Elizabeth R Emanuel, Elin Hu, Wen Zhang, Ting-Ting Li, Wen-Bing Jin, Alex Grier, Sanchita Kashyap, Chun-Jun Guo, Frank C Schroeder, David Artis
Innate lymphoid cells (ILCs) can promote host defense, chronic inflammation, or tissue protection and are regulated by cytokines and neuropeptides. However, their regulation by diet and microbiota-derived signals remains unclear. We show that an inulin fiber diet promotes Tph1-expressing inflammatory ILC2s (ILC2INFLAM) in the colon, which produce IL-5 but not tissue-protective amphiregulin (AREG), resulting in the accumulation of eosinophils. This exacerbates inflammation in a murine model of intestinal damage and inflammation in an ILC2- and eosinophil-dependent manner...
May 6, 2024: Journal of Experimental Medicine
#2
Xiaogang Feng, Tilde Andersson, Julia Gschwend, Pascal Flüchter, Ivan Berest, Julian L Muff, Daniele Carchidi, Antonie Lechner, Jeshua C de Tenorio, Nina Brander, Ulrich Boehm, Christoph S N Klose, David Artis, Trese Leinders-Zufall, Frank Zufall, Christoph Schneider
The tuft cell-ILC2 circuit orchestrates rapid type 2 responses upon detecting microbe-derived succinate and luminal helminths. Our findings delineate key mechanistic steps, involving IP3R2 engagement and Ca 2+ flux, governing IL-25 production by tuft cells triggered by succinate detection. While IL-17RB plays a pivotal intrinsic role in ILC2 activation, it exerts a regulatory function in tuft cells. Tuft cells exhibit constitutive Il25 expression, placing them in an anticipatory state that facilitates rapid production of IL-25 protein for ILC2 activation...
March 8, 2024: bioRxiv
#3
Prithviraj Rajebhosale, Mala R Ananth, Ronald Kim, Richard Crouse, Li Jiang, Gretchen López-Hernández, Chongbo Zhong, Christian Arty, Shaohua Wang, Alice Jone, Niraj S Desai, Yulong Li, Marina R Picciotto, Lorna W Role, David A Talmage
Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI p ) comprise the major source of cholinergic input to the basolateral amygdala (BLA). Using a genetically-encoded acetylcholine (ACh) sensor in mice, we demonstrate that BLA-projecting cholinergic neurons can "learn" the association between a naïve tone and a foot shock (training) and release ACh in the BLA in response to the conditioned tone 24h later (recall). In the NBM/SI p cholinergic neurons express the immediate early gene, Fos following both training and memory recall...
February 9, 2024: Research Square
#4
JOURNAL ARTICLE
Jianliang Huang, Kun Deng, Ying Liu, Mingkai Xia, Mingsheng Lei, Minghua Wu
BACKGROUND: ILCs play important roles in the brain, gut, and lungs. Researchers are attempting to establish a research framework on the brain-gut-lung axis using ILCs. However, no one has yet conducted a bibliometric analysis to summarize the findings. In this study, we utilized bibliometrics to analyze the emerging trends and focal areas of ILCs in the brain, intestine, and lung. We aim to provide references for future research on the brain-gut-lung axis. METHODS: To conduct a comprehensive bibliometric analysis on ILCs in the fields of brain, intestine, and lung, we utilized software such as HistCite, VOSviewer, and CiteSpace...
2024: Frontiers in Immunology
#5
REVIEW
Elizabeth Emanuel, Mohammad Arifuzzaman, David Artis
The epithelial lining of the respiratory tract and intestine provides a critical physical barrier to protect host tissues against environmental insults including dietary antigens, allergens, chemicals, and microorganisms. In addition, specialized epithelial cells directly communicate with hematopoietic and neuronal cells. These epithelial-immune and epithelial-neuronal interactions control host immune responses and have important implications for inflammatory conditions associated with defects in the epithelial barrier, including asthma, allergy, and inflammatory bowel diseases (IBD)...
February 16, 2024: Journal of Allergy and Clinical Immunology
#6
JOURNAL ARTICLE
Prithviraj Rajebhosale, Mala R Ananth, Ronald Kim, Richard B Crouse, Li Jiang, Gretchen López-Hernández, Chongbo Zhong, Christian Arty, Shaohua Wang, Alice Jone, Niraj S Desai, Yulong Li, Marina R Picciotto, Lorna W Role, David A Talmage
Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SIp ) comprise the major source of cholinergic input to the basolateral amygdala (BLA). Using a genetically-encoded acetylcholine (ACh) sensor in mice, we demonstrate that BLA-projecting cholinergic neurons can 'learn' the association between a naïve tone and a foot shock (training) and release ACh in the BLA in response to the conditioned tone 24h later (recall). In the NBM/SIp cholinergic neurons express the immediate early gene, Fos following both training and memory recall...
February 16, 2024: ELife
#7
JOURNAL ARTICLE
Zhenlong Li, Rui Ma, Hejun Tang, Jiamin Guo, Zahir Shah, Jianying Zhang, Ningyuan Liu, Shuai Cao, Guido Marcucci, David Artis, Michael A Caligiuri, Jianhua Yu
The therapeutic potential for human type 2 innate lymphoid cells (ILC2s) has been underexplored. Although not observed in mouse ILC2s, we found that human ILC2s secrete granzyme B (GZMB) and directly lyse tumor cells by inducing pyroptosis and/or apoptosis, which is governed by a DNAM-1-CD112/CD155 interaction that inactivates the negative regulator FOXO1. Over time, the high surface density expression of CD155 in acute myeloid leukemia cells impairs the expression of DNAM-1 and GZMB, thus allowing for immune evasion...
February 1, 2024: Cell
#8
REVIEW
Mohammad Arifuzzaman, Nicholas Collins, Chun-Jun Guo, David Artis
Nutrition profoundly shapes immunity and inflammation across the lifespan of mammals, from pre- and post-natal periods to later life. Emerging insights into diet-microbiota interactions indicate that nutrition has a dominant influence on the composition-and metabolic output-of the intestinal microbiota, which in turn has major consequences for host immunity and inflammation. Here, we discuss recent findings that support the concept that dietary effects on microbiota-derived metabolites potently alter immune responses in health and disease...
January 9, 2024: Immunity
#9
JOURNAL ARTICLE
Masato Tamari, Kate L Del Bel, Aaron M Ver Heul, Lydia Zamidar, Keisuke Orimo, Masato Hoshi, Anna M Trier, Hiroshi Yano, Ting-Lin Yang, Catherine M Biggs, Kenichiro Motomura, Rintaro Shibuya, Chuyue D Yu, Zili Xie, Hisato Iriki, Zhen Wang, Kelsey Auyeung, Gargi Damle, Deniz Demircioglu, Jill K Gregory, Dan Hasson, Jinye Dai, Rui B Chang, Hideaki Morita, Kenji Matsumoto, Sanjay Jain, Steven Van Dyken, Joshua D Milner, Dusan Bogunovic, Hongzhen Hu, David Artis, Stuart E Turvey, Brian S Kim
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with JAK1 gain-of-function (GoF) variants develop atopic dermatitis (AD) and asthma. To explore tissue-specific functions, we inserted a human JAK1 GoF variant (JAK1GoF ) into mice and observed the development of spontaneous AD-like skin disease but unexpected resistance to lung inflammation when JAK1GoF expression was restricted to the stroma. We identified a previously unrecognized role for JAK1 in vagal sensory neurons in suppressing airway inflammation...
January 4, 2024: Cell
#10
JOURNAL ARTICLE
Timothy J D Ohlsen, Huiqi Wang, David Buchbinder, I-Chan Huang, Arti D Desai, Zhiyuan Zheng, Anne C Kirchhoff, Elyse R Park, Kevin Krull, Rena M Conti, Yutaka Yasui, Wendy Leisenring, Gregory T Armstrong, K Robin Yabroff, Paul C Nathan, Eric J Chow
BACKGROUND: Siblings of children with cancer may experience adverse household economic consequences, but their financial outcomes in adulthood are unknown. METHODS: A total of 880 siblings (aged 18-64 years) of adult-aged childhood cancer survivors were surveyed to estimate the prevalence of financial hardship by three established domains (behavioral, material, and psychological). For individual financial hardship items matching the contemporaneous National Health Interview Survey or Behavioral Risk Factor Surveillance System, siblings were compared with the general population by calculating adjusted prevalence odds ratios (ORs) to sample-weighted responses...
December 15, 2023: Cancer
#11
JOURNAL ARTICLE
Cynthia Turnbull, Josiah Bones, Maurice Stanley, Arti Medhavy, Hao Wang, Ayla May D Lorenzo, Jean Cappello, Somasundhari Shanmuganandam, Abhimanu Pandey, Sandali Seneviratne, Grant J Brown, Xiangpeng Meng, David Fulcher, Gaetan Burgio, Si Ming Man, Carmen de Lucas Collantes, Mercedes Gasior, Eduardo López Granados, Pilar Martin, Simon H Jiang, Matthew C Cook, Julia I Ellyard, Vicki Athanasopoulos, Ben Corry, Pablo F Canete, Carola G Vinuesa
Autosomal dominant loss-of-function (LoF) variants in cytotoxic T-lymphocyte associated protein 4 ( CTLA4 ) cause immune dysregulation with autoimmunity, immunodeficiency and lymphoproliferation (IDAIL). Incomplete penetrance and variable expressivity are characteristic of IDAIL caused by CTLA-4 haploinsufficiency (CTLA-4h), pointing to a role for genetic modifiers. Here, we describe an IDAIL proband carrying a maternally inherited pathogenic CTLA4 variant and a paternally inherited rare LoF missense variant in CLEC7A, which encodes for the β-glucan pattern recognition receptor DECTIN-1...
December 8, 2023: Science Advances
#12
JOURNAL ARTICLE
David Artis
Working at the intersection of neuroscience and immunology, David Artis shares his lifelong passion for science, starting with harassing Venus flytraps as a child and his optimism for science's future. Further, he offers insight into neuroscience and immunology's unique parallelism.
November 1, 2023: Neuron
#13
JOURNAL ARTICLE
Sarah Naguib, Jon R Backstrom, Elisabeth Artis, Purnima Ghose, Amy Stahl, Rachael Hardin, Ameer A Haider, John Ang, David J Calkins, Tonia S Rex
Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We have shown that elevated IOP causes an early increase in levels of reactive oxygen species (ROS) in the microbead occlusion mouse model. We also detected an endogenous antioxidant response mediated by Nuclear factor erythroid 2-Related Factor 2 (NRF2), a transcription factor that binds to the antioxidant response element (ARE) and increases transcription of antioxidant genes...
October 24, 2023: Acta Neuropathologica Communications
#14
Siva Naga S Yarrarapu, Abdul-Rahaman Adedolapo Ottun, Fnu Arty, Jayasree Ravilla, Gaurav Mohan, Muhammad Tayyeb, David Anwar
Infective endocarditis can be acute or subacute. It can be caused by viral, bacterial, fungal, and sometimes nonbacterial etiologies. It is an important cause of mortality and morbidity in children as well as adolescents, despite advances in management. A 59-year-old male with a past medical history of aortic valve (AV) replacement on warfarin presented to the Emergency Department with dull right flank pain and poor dentition on examination. Computerized tomography (CT) scans of the abdomen revealed the presence of splenic and renal infarcts...
September 2023: Curēus
#15
REVIEW
Dietmar M W Zaiss, Edward J Pearce, David Artis, Andrew N J McKenzie, Christoph S N Klose
Type 2 immune responses form a critical defence against enteric worm infections. In recent years, mouse models have revealed shared and unique functions for group 2 innate lymphoid cells and T helper 2 cells in type 2 immune response to intestinal helminths. Both cell types use similar innate effector functions at the site of infection, whereas each population has distinct roles during different stages of infection. In this Perspective, we review the underlying mechanisms used by group 2 innate lymphoid cells and T helper 2 cells to cooperate with each other and suggest an overarching model of the interplay between these cell types over the course of a helminth infection...
October 5, 2023: Nature Reviews. Immunology
#16
JOURNAL ARTICLE
Megan E Carey, Zoe A Dyson, Danielle J Ingle, Afreenish Amir, Mabel K Aworh, Marie Anne Chattaway, Ka Lip Chew, John A Crump, Nicholas A Feasey, Benjamin P Howden, Karen H Keddy, Mailis Maes, Christopher M Parry, Sandra Van Puyvelde, Hattie E Webb, Ayorinde Oluwatobiloba Afolayan, Anna P Alexander, Shalini Anandan, Jason R Andrews, Philip M Ashton, Buddha Basnyat, Ashish Bavdekar, Isaac I Bogoch, John D Clemens, Kesia Esther da Silva, Anuradha De, Joep de Ligt, Paula Lucia Diaz Guevara, Christiane Dolecek, Shanta Dutta, Marthie M Ehlers, Louise Francois Watkins, Denise O Garrett, Gauri Godbole, Melita A Gordon, Andrew R Greenhill, Chelsey Griffin, Madhu Gupta, Rene S Hendriksen, Robert S Heyderman, Yogesh Hooda, Juan Carlos Hormazabal, Odion O Ikhimiukor, Junaid Iqbal, Jobin John Jacob, Claire Jenkins, Dasaratha Ramaiah Jinka, Jacob John, Gagandeep Kang, Abdoulie Kanteh, Arti Kapil, Abhilasha Karkey, Samuel Kariuki, Robert A Kingsley, Roshine Mary Koshy, A C Lauer, Myron M Levine, Ravikumar Kadahalli Lingegowda, Stephen P Luby, Grant Austin Mackenzie, Tapfumanei Mashe, Chisomo Msefula, Ankur Mutreja, Geetha Nagaraj, Savitha Nagaraj, Satheesh Nair, Take K Naseri, Susana Nimarota-Brown, Elisabeth Njamkepo, Iruka N Okeke, Sulochana Putli Bai Perumal, Andrew J Pollard, Agila Kumari Pragasam, Firdausi Qadri, Farah N Qamar, Sadia Isfat Ara Rahman, Savitra Devi Rambocus, David A Rasko, Pallab Ray, Roy Robins-Browne, Temsunaro Rongsen-Chandola, Jean Pierre Rutanga, Samir K Saha, Senjuti Saha, Karnika Saigal, Mohammad Saiful Islam Sajib, Jessica C Seidman, Jivan Shakya, Varun Shamanna, Jayanthi Shastri, Rajeev Shrestha, Sonia Sia, Michael J Sikorski, Ashita Singh, Anthony M Smith, Kaitlin A Tagg, Dipesh Tamrakar, Arif Mohammed Tanmoy, Maria Thomas, Mathew S Thomas, Robert Thomsen, Nicholas R Thomson, Siaosi Tupua, Krista Vaidya, Mary Valcanis, Balaji Veeraraghavan, François-Xavier Weill, Jackie Wright, Gordon Dougan, Silvia Argimón, Jacqueline A Keane, David M Aanensen, Stephen Baker, Kathryn E Holt
BACKGROUND: The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks 22 years since the publication of the first Typhi genome, represents the largest Typhi genome sequence collection to date (n=13,000). METHODS: This is a meta-analysis of global genotype and antimicrobial resistance (AMR) determinants extracted from previously sequenced genome data and analysed using consistent methods implemented in open analysis platforms GenoTyphi and Pathogenwatch...
September 12, 2023: ELife
#17
REVIEW
Brian Kim, Marc E Rothenberg, Xin Sun, Claus Bachert, David Artis, Raza Zaheer, Yamo Deniz, Paul Rowe, Sonya Cyr
Type 2 inflammation is characterized by overexpression and heightened activity of type 2 cytokines, mediators, and cells that drive neuroimmune activation and sensitization to previously subthreshold stimuli. The consequences of altered neuroimmune activity differ by tissue type and disease; they include skin inflammation, sensitization to pruritogens, and itch amplification in atopic dermatitis and prurigo nodularis; airway inflammation and/or hyperresponsiveness, loss of expiratory volume, airflow obstruction and increased mucus production in asthma; loss of sense of smell in chronic rhinosinusitis with nasal polyps; and dysphagia in eosinophilic esophagitis...
August 25, 2023: Journal of Allergy and Clinical Immunology
#18
Siva Naga S Yarrarapu, Parth Shah, Fnu Arty, Jayasree Ravilla, Medha Ghose, Mahrukh A Khan, David Anwar
Cardiac tamponade is considered a medical emergency because a patient can deteriorate easily and die of cardiac arrest if the fluid is not drained immediately. The most common etiologies are the same as pericarditis as fluid accumulates due to pericardial inflammation, including infection, malignancy, trauma, iatrogenic, autoimmune, post-myocardial infarction, radiation, and renal failure. Although the treatment is pericardiocentesis or pericardial window, finding the etiology responsible for the development of pericardial effusion is important...
July 2023: Curēus
#19
JOURNAL ARTICLE
Cyrille Adiang Mezoue, Yannick Cedric Ngangmo, Arti Choudhary, David Monkam
Due to absence of data on air quality monitoring and pollutant emissions in Douala, a measurement campaign along the principal street passage to the college grounds was started. Using the OC 300 Laser Dust Particle, fine particle concentrations are monitored during 1 week from Monday to Sunday. The instrument used detects four different sizes of particles: PM10 , PM5 , PM2.5 , and PM1 . The daily average concentrations measured ranged from 9.47 ± 0.26 to 50.14 ± 2...
July 18, 2023: Environmental Monitoring and Assessment
#20
JOURNAL ARTICLE
Daniel S Park, Xiao Feng, Shinobu Akiyama, Marlina Ardiyani, Neida Avendaño, Zoltan Barina, Blandine Bärtschi, Manuel Belgrano, Julio Betancur, Roxali Bijmoer, Ann Bogaerts, Asunción Cano, Jiří Danihelka, Arti Garg, David E Giblin, Rajib Gogoi, Alessia Guggisberg, Marko Hyvärinen, Shelley A James, Ramagwai J Sebola, Tomoyuki Katagiri, Jonathan A Kennedy, Tojibaev Sh Komil, Byoungyoon Lee, Serena M L Lee, Donatella Magri, Rossella Marcucci, Siro Masinde, Denis Melnikov, Patrik Mráz, Wieslaw Mulenko, Paul Musili, Geoffrey Mwachala, Burrell E Nelson, Christine Niezgoda, Carla Novoa Sepúlveda, Sylvia Orli, Alan Paton, Serge Payette, Kent D Perkins, Maria Jimena Ponce, Heimo Rainer, L Rasingam, Himmah Rustiami, Natalia M Shiyan, Charlotte Sletten Bjorå, James Solomon, Fred Stauffer, Alex Sumadijaya, Mélanie Thiébaut, Barbara M Thiers, Hiromi Tsubota, Alison Vaughan, Risto Virtanen, Timothy J S Whitfeld, Dianxiang Zhang, Fernando O Zuloaga, Charles C Davis
Herbarium collections shape our understanding of Earth's flora and are crucial for addressing global change issues. Their formation, however, is not free from sociopolitical issues of immediate relevance. Despite increasing efforts addressing issues of representation and colonialism in natural history collections, herbaria have received comparatively less attention. While it has been noted that the majority of plant specimens are housed in the Global North, the extent and magnitude of this disparity have not been quantified...
June 12, 2023: Nature Human Behaviour
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