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https://www.readbyqxmd.com/read/27926952/growth-hormone-treatment-increases-plasma-irisin-concentration-in-patients-with-turner-syndrome
#1
B Wikiera, K Zawadzka, Ł Łaczmański, N Słoka, M Bolanowski, A Basiak, A Noczyńska, J Daroszewski
Irisin (Ir) deficiency may be a contributing factor in metabolic disease. This study aimed to investigate the effect of supraphysiological doses of recombinant human growth hormone (rhGH) on Ir plasma concentration in relation to metabolic disorders, including obesity and other components of metabolic syndrome. We studied 36 girls with Turner syndrome (mean age 8.2 years) treated with rhGH (0.05 mg/kg/day). Anthropometric data and fasting blood levels [e. g., Ir, insulin, glucose, glycated hemoglobin (HbA1c), IGF-1, IGFBP-3, cholesterol, insulin resistance (HOMA-IR), and β-cell function (HOMA-β)] were analyzed prior to and following rhGH therapy [mean (SD) follow-up of 1...
December 7, 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27926856/insulin-dependent-activation-of-mch-neurons-impairs-locomotor-activity-and-insulin-sensitivity-in-obesity
#2
A Christine Hausen, Johan Ruud, Hong Jiang, Simon Hess, Hristo Varbanov, Peter Kloppenburg, Jens C Brüning
Melanin-concentrating-hormone (MCH)-expressing neurons (MCH neurons) in the lateral hypothalamus (LH) are critical regulators of energy and glucose homeostasis. Here, we demonstrate that insulin increases the excitability of these neurons in control mice. In vivo, insulin promotes phosphatidylinositol 3-kinase (PI3K) signaling in MCH neurons, and cell-type-specific deletion of the insulin receptor (IR) abrogates this response. While lean mice lacking the IR in MCH neurons (IR(ΔMCH)) exhibit no detectable metabolic phenotype under normal diet feeding, they present with improved locomotor activity and insulin sensitivity under high-fat-diet-fed, obese conditions...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926649/association-of-gestational-weight-gain-expectations-and-advice-on-actual-weight-gain
#3
Rebecca A Krukowski, Delia S West, Marisha DiCarlo, Mario A Cleves, Marie E Saylors, Aline Andres
OBJECTIVE: To examine pregnant women's gestational weight gain expectations and advice from various sources (ie, self, family and friends, physician) and the association of these sources of expectations and advice with measured gestational weight gain. METHODS: This is a secondary analysis of a cohort study of 230 pregnant women in their second pregnancy. Each woman was queried at 12 weeks of gestation about the amount of weight: 1) she felt was "healthy" to gain, 2) she expected to gain, 3) her friends and family thought she should gain, and 4) the specificity of her physician's advice about gestational weight gain...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926527/meqtl-analysis-of-childhood-obesity-links-epigenetics-with-a-risk-snp-rs17782313-near-mc4r-from-meta-analysis
#4
Yuping Tang, Bo Jin, Lingling Zhou, Weifeng Lu
Earlier GWAS has identified that rs17782313 near MC4R was associated with obesity. However, subsequent studies showed conflicting results, especially among childhood. Besides, the mechanisms underlying the association between rs17782313 and childhood obesity remain largely unexplored, and genetic and epigenetic may interact and together affect the development of childhood obesity. We conducted a comprehensive meta-analysis to assess the association between rs17782313 and childhood obesity. MeQTL and eQTL analysis was applied to explore the effect of rs17782313 on DNA methylation and MC4R expression...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27926473/growth-differentiation-factor-15-increases-following-oral-glucose-ingestion-effect-of-meal-composition-and-obesity
#5
Marie Helene Schernthaner-Reiter, Dominik Kasses, Christina Tugendsam, Michaela Riedl, Slobodan Peric, Gerhard Prager, Michael Krebs, Miriam Promintzer-Schifferl, Martin Clodi, Anton Luger, Greisa Vila
OBJECTIVE: Growth differentiation factor 15 (GDF15) is a cardiovascular biomarker belonging to the transforming growth factor-β superfamily. Increased GDF15 concentrations are associated with insulin resistance, diabetes and obesity. We investigated the physiological effects of meal composition and obesity on the regulation of systemic GDF15 levels. DESIGN: Lean (n = 8) and obese (n = 8) individuals received a carbohydrate- or fat-rich meal, a 75 g oral glucose load (OGTT) or short-term fasting...
December 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27926437/involvement-of-opioid-signaling-in-food-preference-and-motivation-studies-in-laboratory-animals
#6
I Morales, L Font, P J Currie, R Pastor
Motivation is a complex neurobiological process that initiates, directs, and maintains goal-oriented behavior. Although distinct components of motivated behavior are difficult to investigate, appetitive and consummatory phases of motivation are experimentally separable. Different neurotransmitter systems, particularly the mesolimbic dopaminergic system, have been associated with food motivation. Over the last two decades, however, research focusing on the role of opioid signaling has been particularly growing in this area...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27925869/endovascular-management-of-infected-iliofemoral-pseudoaneurysms-a-systematic-review
#7
Konstantinos G Moulakakis, Vangelis G Alexiou, George S Sfyroeras, John Kakisis, Andreas Lazaris, Spyridon N Vasdekis, Elias N Brountzos, George Geroulakos
We conducted a systematic review regarding the efficacy and outcome of endovascular treatment of infected iliofemoral arterial pseudoaneurysms with covered stents. 35 cases were identified, including 5 own. 22 pseudoaneurysms were located in the femoral area and 13 in the iliac vessels. The most commonly reported complaints were pulsatile groin mass (40 %), sepsis (37.1 %), active bleeding (31.4 %), and groin infection with purulent discharge (17.1 %). S. aureus (65.7 %) and Streptococcus species (22.9 %) were the most common microbes isolated...
December 7, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27925858/physical-activity-contributes-to-several-sleep-cardiometabolic-health-relationships
#8
Thirumagal Kanagasabai, Michael C Riddell, Chris I Ardern
PURPOSE: To estimate the contribution of accelerometer-derived physical activity to the relationship between sleep and cardiometabolic health. METHODS: Data from the 2005 to 2006 US National Health and Nutritional Examination Survey were used (N = 1226; 20 years+). Metabolic syndrome (MetS) was defined by the Joint Interim Statement, and sleep quality and quantity by the Sleep Disorders Questionnaire. Physical activity intensities were defined by activity thresholds (counts per minute) as sedentary activity (0-99), light intensity (100-759), lifestyle activity (760-2019), moderate intensity (2020-5996), and vigorous intensity (≥5999)...
December 7, 2016: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/27925826/obesity-among-night-shift-nurses-time-to-intervene
#9
Gwen Margaret Williams
No abstract text is available yet for this article.
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27925657/population-pharmacokinetics-of-cefazolin-in-serum-and-adipose-tissue-from-overweight-and-obese-women-undergoing-cesarean-delivery
#10
Mordechai Grupper, Joseph L Kuti, Morgan L Swank, Lindsay Maggio, Brenna L Hughes, David P Nicolau
The optimal antibiotic prophylaxis dosing regimen of cefazolin for cesarean delivery (CD) in overweight and obese women is unknown. This study was done to compare the duration that cefazolin concentrations remain above the minimum inhibitory concentration (MIC) in adipose tissue (AT). Serum and AT concentrations from 3 previous studies in CD patients were comodeled using the nonparametric adaptive grid algorithm in Pmetrics. AT concentrations for 5000 overweight and obese patients receiving 1-, 2-, and 3-g cefazolin regimens were simulated to calculate the probability that free drug concentrations remained above an MIC of 2 μg/mL at 1, 1...
December 7, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27925457/now-is-the-time-to-improve-access-and-healthcare-systems-for-childhood-obesity-treatment
#11
Robert I Berkowitz, Stephen Daniels
No abstract text is available yet for this article.
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27925451/improving-access-and-systems-of-care-for-evidence-based-childhood-obesity-treatment-conference-key-findings-and-next-steps
#12
REVIEW
Denise E Wilfley, Amanda E Staiano, Myra Altman, Jeanne Lindros, Angela Lima, Sandra G Hassink, William H Dietz, Stephen Cook
OBJECTIVE: To improve systems of care to advance implementation of the U.S. Preventive Services Task Force recommendations for childhood obesity treatment (i.e., clinicians offer/refer children with obesity to intensive, multicomponent behavioral interventions of >25 h over 6 to 12 months to improve weight status) and to expand payment for these services. METHODS: In July 2015, 43 cross-sector stakeholders attended a conference supported by the Agency for Healthcare Research and Quality, American Academy of Pediatrics Institute for Healthy Childhood Weight, and The Obesity Society...
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27925445/relationship-between-obesity-and-anti-m%C3%A3-llerian-hormone-in-reproductive-aged-african-american-women
#13
Lia A Bernardi, Mercedes R Carnethon, Peter J de Chavez, Deborah E Ikhena, Lisa M Neff, Donna D Baird, Erica E Marsh
OBJECTIVE: To determine whether there is an association between obesity and anti-Müllerian hormone (AMH) among reproductive-aged African American women (AAW). METHODS: From the women participating in an ongoing National Institute of Environmental Health Sciences study, 1,654 AAW aged 23 to 35 were included in this study. Anthropometric measurements, personal health information, and serum AMH and adipokine levels were analyzed. RESULTS: The median body mass index (BMI) was 32...
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27925437/efficacy-of-a-gender-tailored-intervention-to-prevent-weight-regain-in-men-over-3-years-a-weight-loss-maintenance-rct
#14
Myles D Young, Robin Callister, Clare E Collins, Ronald C Plotnikoff, Elroy J Aguiar, Philip J Morgan
OBJECTIVE: To examine whether a gender-tailored weight loss maintenance (WLM) program could reduce men's weight regain following weight loss. METHODS: Ninety-two men who lost at least 4 kg during a 3-month weight loss phase were randomized to receive: (i) a 6-month WLM program (WL + WLM; n = 47) or (ii) no resources (WL-only; n = 45). The WLM program included written materials and messages (SMS, video email) plus other resources (e.g., pedometer, Gymstick™)...
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27925416/association-of-a-gain-of-function-variant-in-lgr4-with-central-obesity
#15
Yaoyu Zou, Tinglu Ning, Juan Shi, Maopei Chen, Lin Ding, Ya Huang, Sophie Kauderer, Min Xu, Bin Cui, Yufang Bi, Simin Liu, Jie Hong, Ruixin Liu, Guang Ning, Jiqiu Wang
OBJECTIVE: To determine the relationship of the gain-of-function variant A750T in leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) with central obesity and related metabolic phenotypes. METHODS: The LGR4 A750T (c.2248 G > A) variant was detected by Sanger sequencing in a discovery young population and a validation community-based population with obesity from eastern China. Fat indices determined by anthropometry and computed tomography scans and clinical biochemical measurements were collected for association analysis...
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27925407/population-level-decline-in-bmi-and-systolic-blood-pressure-following-mass-hiv-treatment-evidence-from-rural-kwazulu-natal
#16
Pascal Geldsetzer, Andrea B Feigl, Frank Tanser, Dickman Gareta, Deenan Pillay, Till Bärnighausen
OBJECTIVE: Clinic-based studies have shown that patients with human immunodeficiency virus (HIV) gain weight after initiation of antiretroviral therapy (ART). This study aimed to determine whether the scale-up of ART was associated with a population-level increase in body mass index (BMI) and blood pressure (BP) in a community with high HIV and obesity prevalence. METHODS: A household survey was conducted in rural KwaZulu-Natal before ART scale-up (in 2004) and when ART coverage had reached 25% (in 2010)...
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27925359/effect-of-aerobic-exercise-intervention-on-markers-of-insulin-resistance-in-breast-cancer-women
#17
E Bruno, E Roveda, J Vitale, A Montaruli, F Berrino, A Villarini, E Venturelli, G Gargano, L Galasso, A Caumo, F Carandente, P Pasanisi
Insulin may affect breast cancer (BC) risk and prognosis. Exercise reduces insulin in obese BC survivors. We designed a randomised controlled trial to test the effect of an aerobic exercise intervention (AEI) on insulin parameters and body composition in non-obese BC women without insulin resistance. Thirty-eight BC women were randomised into an intervention group (IG = 18) or control group (CG = 20). IG participated in a structured AEI for 3 months, while CG received only the Word Cancer Research Fund/American Institute Cancer Research (WCRF/AICR) recommendation to be physically active...
December 7, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27925328/screening-for-preeclampsia-in-the-first-trimester-the-usefulness-of-maternal-hemodynamics-and-bioimpedence-in-non-obese-patients
#18
Giulia Gagliardi, Grazia Maria Tiralongo, Damiano Lo Presti, Ilaria Pisani, Daniele Farsetti, Barbara Vasapollo, Gian Paolo Novelli, Angela Andreoli, Herbert Valensise
OBJECTIVE: To test if maternal hemodynamics, and bioimpedance, together with the Combined Screening (maternal history, biophysical and biochemical markers), are able to identify normotensive non-obese patients at risk for preeclampsia (PE) and/or intrauterine growth restriction (IUGR) in the first trimester of gestation. METHODS: 150 healthy nulliparous non-obese women (BMI<30Kg/m(2) ) were enrolled in the study in the first trimester of pregnancy and submitted to USCOM to detect hemodynamic parameters, bioimpedence to characterize body composition, and combined screening for preeclampsia (maternal history, biophysical and maternal biochemical markers)...
December 7, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27925245/helminths-hygiene-hypothesis-and-type-2-diabetes
#19
Karin de Ruiter, Dicky L Tahapary, Erliyani Sartono, Pradana Soewondo, Taniawati Supali, Johannes W A Smit, Maria Yazdanbakhsh
Worldwide, there is little overlap between the prevalence of soil-transmitted helminths and type 2 diabetes (T2D). Helminth-induced type 2 immune responses and immune regulatory network might modulate the obesity-induced activation of inflammatory pathways that are associated with the development of insulin resistance, a strong predictor of the development of T2D. However, other factors such as helminth-associated changes in adiposity and gut microbiome might also contribute to improved metabolic outcomes. In this review we summarize epidemiological evidence for the link between helminths and T2D and discuss the potential mechanisms, based on findings from experimental studies as well as the limited number of studies in humans...
December 7, 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27925195/palmitoleic-acid-improves-metabolic-functions-in-fatty-liver-by-ppar%C3%AE-dependent-ampk-activation
#20
Camila O Souza, Alexandre A S Teixeira, Luana A Biondo, Edson A Lima, Helena A P Batatinha, Jose C Rosa Neto
BACKGROUND: Palmitoleic acid, since described as lipokine, increases glucose uptake by modulation of 5'AMP-activated protein kinase (AMPK), as well as increasing lipolysis by activation of peroxisome proliferator-activated receptor-α (PPARα), in adipose tissue. However in liver, the effects of palmitoleic acid on glucose metabolism and the role of PPARα remain unknown. OBJECTIVE: To investigate whether palmitoleic acid improved the hepatic insulin sensitivity of obese mice...
December 7, 2016: Journal of Cellular Physiology
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