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https://www.readbyqxmd.com/read/29241213/antibiotics-induced-obesity-a-mitochondrial-perspective
#1
Melisa J Andrade, Chinchu Jayaprakash, Smitha Bhat, Nikolaos Evangelatos, Angela Brand, Kapaettu Satyamoorthy
Antibiotics are the first line of treatment against infections and have contributed immensely to reduce the morbidity and mortality rates. Recently, extensive use of antibiotics has led to alterations of the gut microbiome, predisposition to various diseases and most importantly, increase in the emergence of antibiotic-resistant bacteria, which poses a major threat to global public health. Another major issue faced worldwide due to unregulated use of antibiotics in children as well as in adults is the influence of metabolism and body weight homeostasis, leading to obesity...
December 15, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/29241180/high-mobility-group-box1-inhibitor-glycyrrhizic-acid-attenuates-kidney-injury-in-streptozotocin-induced-diabetic-rats
#2
Hong Zhang, Ru Zhang, Juan Chen, Min Shi, Wei Li, Xiangcheng Zhang
BACKGROUND/AIMS: High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and mechanisms of an HMGB1 inhibitor, glycyrrhizic acid (GA), in renal injury with the streptozotocin (STZ)-induced rat model. METHODS: The diabetic rat was generated by intraperitoneal injection of STZ and then treated with the HMGB1 inhibitor GA or saline for 8 weeks...
November 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29241148/obesity-exacerbates-the-acute-metabolic-side-effects-of-olanzapine
#3
Logan K Townsend, Willem T Peppler, Natasha D Bush, David C Wright
Olanzapine is a second-generation antipsychotic used in the management of schizophrenia and various off-label conditions. The acute metabolic responses of olanzapine recapitulate many of the side effects associated with obesity. Obesity rates are high in the schizophrenic population, but it is unknown whether pre-existing obesity-associated metabolic dysfunction augments the acute side effects of olanzapine. To address this question, we compared the responses to olanzapine in lean and high-fat diet-induced (HFD) obese mice...
December 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29241051/determination-of-lipid-profiles-in-serum-of-obese-ponies-before-and-after-weight-reduction-by-using-multi-one-dimensional-thin-layer-chromatography
#4
Ratchada Auyyuenyong, Andrea Henze, Julia Ungru, Florian J Schweigert, Jens Raila, Ingrid Vervuert
Obesity is a key component of equine metabolic syndrome, which is highly associated with laminitis. Feed restriction and/or exercise are known to alleviate the detrimental effects of insulin resistance in obese ponies. However, little is known about changes in the serum lipid patterns due to weight reduction and its association with disease outcomes. Therefore, the lipid patterns in the serum of 14 mature ponies before and after a 14-week body weight reduction program (BWRP) were investigated by multi-one-dimensional thin-layer chromatography (MOD-TLC)...
November 21, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29240959/evaluation-of-left-ventricular-function-in-overweight-children-and-teenagers-with-arterial-hypertension-and-white-coat-hypertension
#5
Tomasz Florianczyk, Malgorzata Golabek-Dylewska, Beata Kucinska, Bozena Werner
BACKGROUND: Obesity in childhood is strongly associated with elevated arterial blood pressure and risk of hypertension. The aim of the study was the evaluation of left ventricular function in hypertensive and white coat hypertensive overweight children and teenagers. METHODS: The study group consisted of 74 overweight patients aged 10.3 ± 3.1 years (range: 6-16 years) diagnosed as hypertensive in standard blood pressure measurement. The control group consisted of 31 normotensive and normoweight children...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29240912/taking-obesity-in-older-adults-seriously
#6
Stephen B Kritchevsky
No abstract text is available yet for this article.
December 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29240910/genetic-predisposition-to-obesity-and-medicare-expenditures
#7
George L Wehby, Benjamin W Domingue, Fred Ullrich, Fredric D Wolinsky
Background: The relationship between obesity and health expenditures is not well understood. We examined the relationship between genetic predisposition to obesity measured by a polygenic risk score for body mass index (BMI) and Medicare expenditures. Methods: Biennial interview data from the Health and Retirement Survey for a nationally representative sample of older adults enrolled in fee-for-service Medicare were obtained from 1991 through 2010 and linked to Medicare claims for the same period and to Genome-Wide Association Study (GWAS) data...
December 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29240836/is-quality-of-life-different-between-diabetic-and-non-diabetic-people-the-importance-of-cardiovascular-risks
#8
L M Peña-Longobardo, B Rodríguez-Sánchez, M Mata-Cases, L Rodríguez-Mañas, M Capel, J Oliva-Moreno
BACKGROUND: To analyse and compare the impact of cardiovascular risk factors and disease on health-related quality of life (HRQoL) in people with and without diabetes living in the community. METHODS: We used data of 1,905 people with diabetes and 19,031 people without diabetes from the last Spanish National Health Survey (years 2011-2012). The HRQoL instrument used was the EuroQol 5D-5L, based on time trade-off scores. Matching methods were used to assess any differences in the HRQoL in people with and without diabetes with the same characteristics (age, gender, education level, and healthy lifestyle), according to cardiovascular risk factors and diseases...
2017: PloS One
https://www.readbyqxmd.com/read/29240779/impact-of-maternal-high-fat-diet-on-hypothalamic-transcriptome-in-neonatal-sprague-dawley-rats
#9
Sanna Barrand, Tamsyn M Crowley, Ryan J Wood-Bradley, Kirstie A De Jong, James A Armitage
Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to imbalances in appetite and energy homeostasis and increasing the risk of obesity in subsequent generations. Early in postnatal life, the neuronal projections responsible for energy homeostasis develop in response to appetite-related peptides such as leptin. To date, no study characterises the genome-wide transcriptional changes that occur in response to exposure to high fat diet during this critical window...
2017: PloS One
https://www.readbyqxmd.com/read/29240640/indocyanine-green-angiography-use-in-breast-reconstruction-a-national-analysis-of-outcomes-and-cost-in-110-320-patients
#10
Anmol Chattha, Alexandra Bucknor, Austin D Chen, Bernard T Lee, Samuel J Lin
BACKGROUND: Indocyanine Green (ICG) angiography has gained popularity in breast reconstruction due to its ability to assess the viability of both mastectomy skin and tissue flaps. We aim to analyze trends and outcomes associated with the use of ICG angiography in breast reconstruction. METHODS: Using 2012-2014 data from the Healthcare Cost and Utilization Project National Inpatient Sample, Agency for Healthcare Research and Quality, we identified breast reconstructions that were performed with or without the use of ICG angiography...
December 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29240555/daily-sugar-sweetened-beverage-consumption-by-disability-status-among-adults-in-23-states-and-the-district-of-columbia
#11
Sunkyung Kim, Sohyun Park, Dianna D Carroll, Catherine A Okoro
INTRODUCTION: Information on dietary intake, including sugar-sweetened beverages (SSBs), for adults with disabilities is limited. Such information can inform interventions to prevent chronic disease and promote health among adults with disabilities. The objective of this study was to describe the associations between SSB consumption and disability among adults. METHODS: We examined data on adults aged 18 years or older in 23 states and the District of Columbia who participated in the 2013 Behavioral Risk Factor Surveillance System (n = 150,760)...
December 14, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29240553/promoting-children-s-physical-activity-in-low-income-communities-in-colorado-what-are-the-barriers-and-opportunities
#12
Daniel M Finkelstein, Dana M Petersen, Lisa S Schottenfeld
INTRODUCTION: Colorado has the highest rate of adult physical activity in the United States. However, children in Colorado have a lower rate of physical activity relative to other states, and the rate is lowest among children in low-income households. We conducted focus groups, surveys, and interviews with parents, youth, and stakeholders to understand barriers to physical activity among children in low-income households in Colorado and to identify opportunities to increase physical activity...
December 14, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29240304/weight-status-diet-quality-perceived-stress-and-functional-health-of-caregivers-of-children-with-autism-spectrum-disorder
#13
Xiaoyin Sara Li, Jennifer A Pinto-Martin, Aleda Thompson, Jesse Chittams, Tanja V E Kral
PURPOSE: Caring for children with autism spectrum disorder (ASD) can be highly demanding and can put significant strain on caregivers. To date, little is known about the extent to which caregivers of children with ASD experience increased levels of stress which may adversely affect health outcomes. The purpose of this secondary analysis was to compare caregivers of children with ASD and caregivers of typically developing children (TDC) in weight status, diet quality, perceived stress related to the parenting role, and functional health and well-being...
December 14, 2017: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29240060/-conservative-treatment-of-chronic-diseases-of-lower-limb-veins-major-risks-of-poor-patient-compliance
#14
O V Golovanova, A N Kuznetsov
Presented herein are the results of the Russian part of the International Research Programme 'VEIN ACT' aimed at studying approaches to conservative treatment of chronic vein diseases in the Russian Federation, assessing its efficacy and safety, as well as monitoring the patient compliance. Also discussed are the regimen and results of conservative therapy, depending on patients' gender, age and body mass index, as well as the level of adherence to various methods of treatment in the cohorts concerned. High efficacy of conservative therapy in all patients was confirmed...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29240042/range-of-motion-limitations-of-the-upper-body-in-obese-female-workers
#15
Nicola Cau, Veronica Cimolin, Luisa Brugliera, Giuseppe Ventura, Manuela Galli, Paolo Capodaglio
BACKGROUND: The prevalence of obesity is increasing worldwide, and the economic consequences of an increased percentage of obese workers are relevant in terms of health costs and absences from work. Obesity is associated with reduced participation in the workforce, increased absence from work, disability and health costs, lower salaries and reduced productivity. OBJECTIVES: We aimed at quantifying the limitations in range of motion (ROM) of the upper limb and the trunk of obese workers during basic occupational tasks...
December 14, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29240038/prevalence-of-hypertension-htn-and-cardiovascular-risk-factors-in-a-hospitalized-pediatric-hemophilia-population
#16
Warren Alperstein, Fernando F Corrales-Medina, Leonardo Tamariz, Ana M Palacio, Joanna A Davis
Improved life expectancy in hemophilia has led to a greater interest in age-related disorders. Hypertension (HTN) as well as cardiovascular disease have been increasingly reported in hemophilic adults but there is currently very limited data in the pediatric population. We conducted a cross-sectional study using data from the 2012 National Health Cost and Utilization Project database to determine the prevalence of HTN and associated cardiovascular risk factors in a hospitalized pediatric hemophilia population, between the ages of 0 to 21 years, in comparison with the general pediatric population...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29239795/effects-of-very-low-calorie-diets-on-liver-size-and-weight-loss-in-the-preoperative-period-of-bariatric-surgery-a-systematic-review
#17
REVIEW
Mariana Holderbaum, Daniela Schaan Casagrande, Samanta Sussenbach, Caroline Buss
Restrictive diet implementation in bariatric surgery (BS) preoperative period is common, although its benefits are not well established. This study aimed to assess the effects of very low calorie diets (VLCD) on liver size and weight loss during BS preoperative period. Surgery-related complications were also assessed. A systematic review of the literature was performed. Terms such as "bariatric surgery" and "very low energy diet" were included in the search strategy. Inclusion criteria were adult patients (aged>18 yr); VLCD treatment in BS preoperative period (10 d to 12 wk); and assessment of 1 the following outcomes: weight loss, liver volume reduction, and surgical complications...
October 2, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29239783/early-adulthood-determinants-of-mid-life-leisure-time-physical-inactivity-stability-and-change-findings-from-a-prospective-birth-cohort
#18
Snehal M Pinto Pereira, Chris Power
OBJECTIVES: Physical inactivity is highly prevalent. Knowledge is needed of influences on inactive lifestyles. We aimed to establish whether early adult factors predict subsequent inactivity patterns in mid-adulthood. DESIGN: Leisure-time inactivity (activity frequency<1/week) was assessed at 33y and 50y in the 1958 British Birth cohort (N=12,271). METHODS: We assessed associations of early adult (23-33y) physical status, mental function, social, family and neighbourhood circumstances with four 33-50y patterns (never inactive, persistently inactive, deteriorating or improving) using multinomial logistic regression with and without adjustment for childhood factors (e...
November 22, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29239576/living-donor-kidney-transplantation
#19
Ilkka Helanterä, Eero Honkanen, Jutta Huhti, Helena Isoniemi, Hannu Jalanko, Marko Lempinen, Marja Miettinen, Arno Nordin, Risto Tertti, Satu Mäkelä
While the majority of kidney transplantations in Finland have been traditionally performed from deceased donors, the frequency of living donors should be increased. Kidney donation is a safe procedure for a carefully examined donor, and for the recipient living donation enables elective surgery and preemptive transplantation. Potential risks for the donor must be minimized, but according to current recommendations, mild hypertension or obesity are not absolute contraindications for donation. Guidelines for donor selection and examination have been updated to simplify the process for all parties...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239537/-does-total-knee-arthroplasty-meet-patient-s-expectations
#20
Didier Hannouche, Diogo Vieira Cardoso, Hermès Miozzari, Anne Lübbeke
Total knee arthroplasty has grown considerably over the past decade, due to the aging of the population, the increase in the prevalence of obesity, and an increasing demand. The 10-year revision rate is less than 5%. Functional outcomes, assessed by range of motion measures and functional scores, were significantly improved with the advent of more reliable and less invasive surgical techniques, better management of postoperative pain, and early high-intensity rehabilitation protocols. However, 20% of patients say they are dissatisfied with their knee replacement, either because of the persistence of pain, or because their function does not match their preoperative expectations...
December 13, 2017: Revue Médicale Suisse
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