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https://www.readbyqxmd.com/read/29691992/breastfeeding-and-growth-during-infancy-among-offspring-of-mothers-with-gestational-diabetes-mellitus-a-prospective-cohort-study
#1
E P Gunderson, L C Greenspan, M S Faith, S R Hurston, C P Quesenberry
BACKGROUND: Breastfeeding (BF) may protect against obesity and type 2 diabetes mellitus in children exposed to maternal diabetes in utero, but its effects on infant growth among this high-risk group have rarely been evaluated. OBJECTIVES: The objective of this study was to evaluate BF intensity and duration in relation to infant growth from birth through 12 months among offspring of mothers with gestational diabetes mellitus (GDM). METHODS: Prospective cohort of 464 GDM mother-infant dyads (28% White, 36% Hispanic, 26% Asian, 8% Black, 2% other)...
April 24, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29691969/obesity-and-the-food-system-transformation-in-latin-america
#2
REVIEW
B M Popkin, T Reardon
The Latin America and the Caribbean (LAC) region faces a major diet-related health problem accompanied by enormous economic and social costs. The shifts in diet are profound: major shifts in intake of less-healthful low-nutrient-density foods and sugary beverages, changes in away-from-home eating and snacking and rapid shifts towards very high levels of overweight and obesity among all ages along with, in some countries, high burdens of stunting. Diet changes have occurred in parallel to, and in two-way causality with, changes in the broad food system - the set of supply chains from farms, through midstream segments of processing, wholesale and logistics, to downstream segments of retail and food service (restaurants and fast food chains)...
April 24, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29691953/circulating-mots-c-levels-are-decreased-in-obese-male-children-and-adolescents-and-associated-with-insulin-resistance
#3
Caiqi Du, Cai Zhang, Wei Wu, Yan Liang, Anru Wang, Shimin Wu, Yue Zhao, Ling Hou, Qin Ning, Xiaoping Luo
BACKGROUND AND AIMS: A novel bioactive peptide, mitochondrial-derived peptide (MOTS-c), has recently attracted attention as a potential prevention or therapeutic option for obesity and type 2 diabetes mellitus (T2DM). MOTS-c profiles have not yet been reported in human obesity and T2DM. We aimed to determine circulating MOTS-c levels in obesity and explore the association between MOTS-c levels and various metabolic parameters. METHODS: In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017...
April 25, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29691916/genomic-signatures-of-fine-scale-local-selection-in-atlantic-salmon-suggest-involvement-of-sexual-maturation-energy-homeostasis-and-immune-defence-related-genes
#4
Victoria L Pritchard, Hannu Mäkinen, Juha-Pekka Vähä, Jaakko Erkinaro, Panu Orell, Craig R Primmer
Elucidating the genetic basis of adaptation to the local environment can improve our understanding of how the diversity of life has evolved. In this study we used a dense SNP array to identify candidate loci potentially underlying fine-scale local adaptation within a large Atlantic salmon (Salmo salar) population. By combining outlier, gene-environment association, and haplotype homozygosity analyses, we identified multiple regions of the genome with strong evidence for diversifying selection. Several of these candidate regions had previously been identified in other studies, demonstrating that the same loci could be adaptively important in Atlantic salmon at sub-drainage, regional and continental scales...
April 25, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29691876/waking-up-too-early-the-consequences-of-preterm-birth-on-sleep-development
#5
Laura Bennet, David W Walker, Rosemary S C Horne
Good quality sleep of sufficient duration is vital for optimal physiological function and our health. Sleep deprivation is associated with impaired neurocognitive function and emotional control, and increases the risk for cardiometabolic diseases, obesity and cancer. Sleep develops during fetal life with the emergence of a recognisable pattern of sleep states in the preterm fetus associated with the development, maturation, and connectivity within neural networks in the brain. Despite the physiological importance of sleep, surprisingly little is known about how sleep develops in individuals born preterm...
April 24, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29691808/total-body-irradiation-for-hematopoietic-stem-cell-transplantation-during-early-childhood-is-associated-with-the-risk-for-diabetes-mellitus
#6
Ryuichi Nakagawa, Atsumi Hosokawa-Tsuji, Yuki Aoki, Kei Takasawa, Mitsue Maru, Keisuke Nakajima, Akito Sutani, Yuichi Miyakawa, Daisuke Tomizawa, Kenichi Kashimada, Tomohiro Morio
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a curative treatment for life-threatening malignancies and related diseases. Recently, the long-term prognosis of HSCT during childhood has greatly improved; however, the late adverse effects of HSCT have been found to cause substantial morbidity among long-term survivors. Although metabolic complications, such as diabetes mellitus (DM) and hyperlipidemia (HL), are the major late effects of pediatric HSCT, the clinical details are not clarified sufficiently...
April 24, 2018: Endocrine
https://www.readbyqxmd.com/read/29691790/operation-change-a-new-paradigm-addressing-behavior-change-and-musculoskeletal-health-disparities
#7
Lynne C Jones, Yashika Watkins, Duanny Alva
BACKGROUND: In this study, we examined the implementation and efficacy of Operation Change, a community-based, culturally sensitive program to stimulate behavioral changes in activity level and improve musculoskeletal health in African-American (AA) and Hispanic/Latina (H/L) women with obesity and early-stage osteoarthritis. METHODS: Sixty-two women (32 AA and 30 H/L), 40-75 years old, with nontraumatic knee pain and body mass index values > 30, participated in a 12-week program of presentations, motivational interviewing, goal setting, and physical activities...
April 24, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29691489/the-relationship-between-yogurt-consumption-body-weight-and-metabolic-profiles-in-youth-with-a-familial-predisposition-to-obesity
#8
Shirin Panahi, Annette Gallant, Angelo Tremblay, Louis Pérusse, Jean-Pierre Després, Vicky Drapeau
BACKGROUND/OBJECTIVES: This study examined the relationship between yogurt consumption, family history of obesity (FHO), and health determinants. SUBJECTS/METHODS: Youth (n = 198; mean age: 20 ± 0.5 years) from the Québec Family Study were first classified based on their FHO, defined as the presence or absence of at least one obese (BMI ≥30 kg/m2 ) parent [with FHO (FHO+; n = 112) or without FHO (FHO-; n = 86)] and then on their yogurt consumption [yogurt consumers (YC+) n = 61 or non-consumers (YC-) n = 137]...
April 25, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29691486/comparison-of-the-prognostic-value-of-different-skeletal-muscle-radiodensity-parameters-in-endometrial-cancer
#9
Nathalia Silva de Paula, Camila Santos Rodrigues, Gabriela Villaça Chaves
BACKGROUND/OBJECTIVES: Recent data have shown that dividing skeletal muscle (SM) into sub-ranges of radiodensity can improve the prediction of short-term outcomes in the oncology setting. We aim to investigate whether the skeletal muscle mass, when divided into sub-ranges of low or high-radiodensity, improves the prediction of short-term survival in endometrial cancer (EC) patients when compared to average muscle attenuation and to the overall skeletal muscle radiodensity. SUBJECTS/METHODS: EC patients who had computed tomography (CT) images available within 30 days before treatment were enrolled in this retrospective cohort (n = 232)...
April 25, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29691422/pulmonary-effects-of-adjusting-tidal-volume-to-actual-or-ideal-body-weight-in-ventilated-obese-mice
#10
Elise Guivarch, Guillaume Voiriot, Anahita Rouzé, Stéphane Kerbrat, Jeanne Tran Van Nhieu, Philippe Montravers, Bernard Maitre, Armand Mekontso Dessap, Mathieu Desmard, Jorge Boczkowski
Obese patients could be more susceptible to mechanical ventilation (MV)-induced lung injury than non-obese patients due to weight-dependent changes in lung properties. The aim of this study was therefore to evaluate the pulmonary effects of 2 hours low VT MV in a diet-induced obese mice model, with VT calculated on either the actual body weight (VT aw) or the ideal body weight (VT iw) . First, we hypothesized that a MV with VT aw would be associated with altered lung mechanics and an increased lung inflammation...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691411/analysis-of-predicted-loss-of-function-variants-in-uk-biobank-identifies-variants-protective-for-disease
#11
Connor A Emdin, Amit V Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M Zekavat, Akihiro Nomura, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Daniel Chasman, Paul Ridker, Joshua Denny, Lisa Bastarache, Judith H Lichtman, Gail D'Onofrio, Jennifer Mattera, John A Spertus, Wayne H-H Sheu, Kent D Taylor, Bruce M Psaty, Stephen S Rich, Wendy Post, Jerome I Rotter, Yii-Der Ida Chen, Harlan Krumholz, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted loss-of-function (pLOF) variants provide insight into effector transcript and direction of biological effect. In >400,000 UK Biobank participants, we conduct association analyses of 3759 pLOF variants with six metabolic traits, six cardiometabolic diseases, and twelve additional diseases...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691174/ten-year-mortality-and-revision-after-total-knee-arthroplasty-in-morbidly-obese-patients
#12
Mina Tohidi, Susan B Brogly, Katherine Lajkosz, Heather J Grant, Elizabeth G VanDenKerkhof, Aaron R Campbell
BACKGROUND: Although morbid obesity has been associated with early surgical complications after total knee arthroplasty (TKA), evidence of long-term outcomes is limited. We conducted a population-based study to determine the association between morbid obesity and 10-year survival and revision surgery in patients undergoing primary TKA. METHODS: A cohort study of 9817 patients aged 18-60 years treated with primary TKA from April 1, 2002 to March 31, 2007 was conducted using Ontario administrative health-care databases of universal health-care coverage...
April 4, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29691131/-overweight-and-obesity-in-children-treated-for-congentital-heart-disease
#13
Francesca Perin, Carmen Carreras Blesa, Maria Del Mar Rodríguez Vázquez Del Rey, Inmaculada Cobo, José Maldonado
INTRODUCTION: The negative impact of overweight and obesity is potentially greater in children affected by a congenital heart disease (CHD). The aim of this study is to calculate the proportion of overweight and obesity in children who underwent an intervention for CHD, and to investigate systolic arterial hypertension as a possible early cardiovascular complication. PATIENTS AND METHODS: A retrospective study was conducted on patients aged 6 to 17 years treated for CHD, and healthy control subjects, followed-up in a Paediatric Cardiology Clinic...
April 21, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29691098/improved-patency-after-axillofemoral-bypass-for-aortoiliac-occlusive-disease
#14
Russell H Samson, David P Showalter, Michael R Lepore, Deepak G Nair, Douglas A Dorsay, Ricardo E Morales
OBJECTIVE: Axillofemoral bypasses (AxFBs) have been used since 1962 to treat aortoiliac disease. In the past, reported patency rates (37%-76%) for these extra-anatomic grafts have been inferior to those for anatomic aortic grafting. Reported low survival rates after AxFB (40%-50%) have confirmed that these procedures have been used primarily in patients at high risk for complications from aortofemoral bypass. However, modern medical and anesthesia management, preoperative scanning, donor artery preparation, postoperative graft surveillance, and graft technology may improve outcomes after AxFB, possibly supporting expansion of its use...
April 21, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29690937/concentration-of-25-hydroxyvitamin-d-from-neonatal-dried-blood-spots-and-the-relation-to-gestational-age-birth-weight-and-ponderal-index-the-d-tect-study
#15
Amélie Keller, Mina N Händel, Peder Frederiksen, Ramune Jacobsen, Arieh S Cohen, John J McGrath, Berit L Heitmann
Studies have suggested that vitamin D status at birth may be associated with a range of neonatal outcomes. The aim of this study was to assess the association between neonatal 25-hydroxyvitamin D3 (25(OH)D3) concentration and gestational age, birth weight, Ponderal Index and size for gestational age. Neonatal capillary blood stored as dried blood spots was used to assess 25(OH)D3 concentrations among 2686 subjects selected from a random population sub-sample of individuals, born in Denmark from 1 May 1981 to 31 December 2002...
April 25, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29690932/a-retrospective-cohort-study-of-body-mass-index-and-survival-in-hiv-infected-patients-with-and-without-tb-co-infection
#16
Kogieleum Naidoo, Nonhlanhla Yende-Zuma, Stanton Augustine
BACKGROUND: High early morbidity and mortality following antiretroviral therapy (ART) initiation has been a distinguishing feature of ART programmes in resource limited settings (RLS) compared to high-income countries. This study assessed how well body mass index (BMI: kg/m2 ) correlated with survival among HIV infected patients with and without TB co-infection. METHODS: We retrospectively evaluated clinical data from 1000 HIV infected patients, among whom 389 were also co-infected with TB, between January 2008 and December 2010, in KwaZulu-Natal, South Africa...
April 25, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29690917/health-consequences-for-mother-and-baby-of-substantial-pre-conception-weight-loss-in-obese-women-study-protocol-for-a-randomized-controlled-trial
#17
Sarah Price, Alison Nankervis, Michael Permezel, Luke Prendergast, Priya Sumithran, Joseph Proietto
BACKGROUND: Current guidelines for the management of obesity in women planning pregnancy suggest lifestyle modification before conception. However, there is little evidence that lifestyle modification alters pregnancy outcomes. Bariatric surgery results in significant weight loss. This appears to reduce the risk of adverse pregnancy outcomes for the mother but may increase the risk of adverse outcomes for the infant. In order to reduce the risks of obesity-related adverse pregnancy outcomes for both mother and offspring, alternative approaches to the management of obesity in women planning pregnancy are needed...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29690903/ccl20-is-up-regulated-in-non-alcoholic-fatty-liver-disease-fibrosis-and-is-produced-by-hepatic-stellate-cells-in-response-to-fatty-acid-loading
#18
Xin Chu, Qunyan Jin, Hui Chen, G Craig Wood, Anthony Petrick, William Strodel, Jon Gabrielsen, Peter Benotti, Tooraj Mirshahi, David J Carey, Christopher D Still, Johanna K DiStefano, Glenn S Gerhard
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors involved in the progression from simple steatosis to fibrosis remain poorly understood. METHODS: Gene expression profiling using microarray, PCR array, and RNA sequencing was performed on RNA from liver biopsy tissue from patients with extreme obesity...
April 24, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29690823/the-need-for-a-patient-tailored-helicobacter-pylori-eradication-protocol-prior-to-bariatric-surgery
#19
Tadeja Pintar, Niko Kaliterna, Tanja Carli
Objective High-quality data indicating the advantages of preoperative Helicobacter pylori screening and eradication as well the clinical outcomes of patients with and without H. pylori after bariatric surgery are lacking. Methods In total, 96 morbidly obese patients with H. pylori preparing for bariatric surgery were retrospectively reviewed. Results Of 96 biopsy specimens, 73 (76%) were positive for H. pylori on initial Giemsa staining. These patients were treated with the standard 7-day antibiotic treatment protocol corrected by the individual patient's creatinine clearance rate and body mass index and received a 30% higher dose because of their H...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29690801/a-link-between-expression-level-of-long-non-coding-rna-zfas1-in-breast-tissue-of-healthy-women-and-obesity
#20
Yaser Mansoori, Mohammad Bagher Tabei, Alireza Askari, Pantea Izadi, Abdolreza Daraei, Mohammad Mehdi Naghizadeh, Zahra Zendehbad, Milad Bastami, Ziba Nariman-Saleh-Fam, Hosein Mansoori, Javad Tavakkoly-Bazzaz
BACKGROUND: Epidemiological and experimental literature indicates that the risk of breast cancer incidence is strongly linked to hormone-dependent factors, including reproductive history and obesity. However, the molecular mechanisms underlying the association between these factors and breast cancer risk are poorly understood. The aim of this study, therefore, was to determine whether obesity and reproductive history are associated with expression levels of two breast cancer-related long non-coding RNAs (lncRNAs), namely ZFAS1 and SRA1 in cancer-free breast tissues of women...
April 1, 2018: International Journal of Biological Markers
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