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https://www.readbyqxmd.com/read/28636933/drosophila-neuropeptide-f-signaling-independently-regulates-feeding-and-sleep-wake-behavior
#1
Brian Y Chung, Jennifer Ro, Sabine A Hutter, Kylie M Miller, Lakshmi S Guduguntla, Shu Kondo, Scott D Pletcher
Proper regulation of sleep-wake behavior and feeding is essential for organismal health and survival. While previous studies have isolated discrete neural loci and substrates important for either sleep or feeding, how the brain is organized to coordinate both processes with respect to one another remains poorly understood. Here, we provide evidence that the Drosophila Neuropeptide F (NPF) network forms a critical component of both adult sleep and feeding regulation. Activation of NPF signaling in the brain promotes wakefulness and adult feeding, likely through its cognate receptor NPFR...
June 20, 2017: Cell Reports
https://www.readbyqxmd.com/read/28636919/monitoring-quantitative-ultrasound-parameter-changes-in-a-cell-pellet-model-of-cell-starvation
#2
Lauren A Wirtzfeld, Elizabeth S L Berndl, Gregory J Czarnota, Michael C Kolios
Although it has previously been shown that the spectral analysis of ultrasound backscatter data is sensitive to the cellular changes caused by apoptosis, the sensitivity of spectral analysis to oncosis or ischemic cell death had not previously been studied. Whereas many anticancer treatments induce apoptosis, others induce cell starvation, or oncosis. HT-29 colon adenocarcinoma cells were formed into pellets and covered in phosphate-buffered saline at room temperature for 56 h. The pellets were imaged every 8 h with high-frequency (55 MHz) ultrasound and the raw radio-frequency data processed...
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28634203/papers-of-note-in-science356-6343
#3
Annalisa M VanHook
This week's articles describe a mechanism by which starvation primes a cellular nutrient-sensing system for activation upon refeeding; microRNAs that control pain sensitivity; and the lasting effects of early life stress on the likelihood of developing depression.
June 20, 2017: Science Signaling
https://www.readbyqxmd.com/read/28633201/rapid-start-up-of-denitrifying-granular-sludge-by-dosing-with-semi-starvation-fluctuation-c-n-ratio-strategy
#4
Wenyu Niu, Jianbo Guo, Jing Lian, Yuanyuan Song, Caicai Lu, Haibo Li, Yi Han, Pengna Yin
This study cultivated denitrifying granular sludge in three UASB reactors by the semi-starvation fluctuation C/N ratio strategy (reactor 1 (R1): constant C/N ratio; R2: regular fluctuation C/N ratio; and R3: semi-starvation fluctuation C/N ratio (SSF)). Microbial aggregates appeared in R1, R2 and R3 on days 28, 14 and 6, respectively. Compared with the results in R1 and R2, the guanosine tetraphosphate (ppGpp) concentration was highest, the acyl homoserine lactones (AHLs) concentration quickly reached a certain threshold, and more protein (PN) of extracellular polymeric substances (EPS) secretion resulted in the rapid formation of denitrifying granular sludge in R3...
June 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28632821/encapsulated-islet-transplantation-where-do-we-stand
#5
Vijayaganapathy Vaithilingam, Sumeet Bal, Bernard E Tuch
Transplantation of pancreatic islets encapsulated within immuno-protective microcapsules is a strategy that has the potential to overcome graft rejection without the need for toxic immunosuppressive medication. However, despite promising preclinical studies, clinical trials using encapsulated islets have lacked long-term efficacy, and although generally considered clinically safe, have not been encouraging overall. One of the major factors limiting the long-term function of encapsulated islets is the host's immunological reaction to the transplanted graft which is often manifested as pericapsular fibrotic overgrowth (PFO)...
2017: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/28631879/context-dependent-effects-of-cold-stress-on-behavioral-physiological-and-life-history-traits-of-the-red-flour-beetle
#6
Inon Scharf, Keren-Or Wertheimer, Joy Lim Xin, Tomer Gilad, Inna Goldenberg, Aziz Subach
Animals are exposed in nature to a variety of stressors. While stress is generally harmful, mild stress can also be beneficial and contribute to reproduction and survival. We studied the effect of five cold shock events vs. a single cold shock and a control group, representing three levels of stress (harsh, mild, and no stress), on behavioral, physiological, and life-history traits of the red flour beetle (Tribolium castaneum, Herbst 1797). Beetles exposed to harsh cold stress were less active than a control group: they moved less and failed more frequently to detect a food patch...
June 20, 2017: Insect Science
https://www.readbyqxmd.com/read/28630667/evaluation-of-radical-scavenging-system-in-amoeba-chaos-carolinense-during-nutrient-deprivation
#7
Yuru Deng, Edlyn Li-Hui Lee, Ketpin Chong, Zakaria A Almsherqi
The frequent appearance of non-lamellar membrane arrangements such as cubic membranes (CMs) in cells under stressed or pathological conditions points to an intrinsic cellular response mechanism. CM represents highly curved, three-dimensional nano-periodic structures that correspond to mathematically well-defined triply periodic minimal surfaces. Specifically, cellular membrane may transform into CM organization in response to pathological, inflammatory and oxidative stress conditions. CM organization, thus, may provide an advantage to cope with various types of stress...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28630042/the-glutamate-cystine-antiporter-slc7a11-xct-enhances-cancer-cell-dependency-on-glucose-by-exporting-glutamate
#8
Pranavi Koppula, Yilei Zhang, Jiejun Shi, Wei Li, Boyi Gan
Cancer cells with specific genetic alterations may be highly dependent on certain nutrients for survival, which can inform therapeutic strategies to target these cancer-specific metabolic vulnerabilities. The glutamate/cystine antiporter solute carrier family 7 member 11 (SLC7A11, also called xCT) is overexpressed in several cancers. Contrasting the established pro-survival roles of SLC7A11 under other stress conditions, here we report an unexpected finding that SLC7A11 overexpression enhances cancer cell dependency on glucose and renders cancer cells more sensitive to glucose starvation-induced cell death, and conversely, that SLC7A11 deficiency by either knockdown or pharmacological inhibition promotes cancer cell survival upon glucose starvation...
June 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28629229/colistin-resistance-associated-with-outer-membrane-protein-change-in%C3%A2-klebsiella-pneumoniae-and-enterobacter-asburiae
#9
Béla Kádár, Béla Kocsis, Ákos Tóth, Katalin Kristóf, Péter Felső, Béla Kocsis, Katalin Böddi, Dóra Szabó
In this study, outer membrane proteins (OMPs) of colistin-resistant Klebsiella pneumoniae and Enterobacter asburiae were analyzed. One colistin-susceptible and three colistin-resistant K. pneumoniae sequence type 258 strains as well as one colistin-susceptible E. asburiae and its colistin-heteroresistant counterpart strain were involved in the study. OMP analysis of each strain was performed by microchip method. Matrix-assisted laser desorption ionization time of flight/mass spectrometry (MALDI-TOF/MS) investigation was carried out after separation of OMPs by two-dimensional gel electrophoresis and in-gel digestion...
June 20, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28628310/furoxan-nitric-oxide-donors-disperse-pseudomonas-aeruginosa-biofilms-accelerate-growth-and-repress-pyoverdine-production
#10
Wee Han Poh, Nicolas Barraud, Stefano Guglielmo, Loretta Lazzarato, Barbara Rolando, Roberta Fruttero, Scott A Rice
The use of nitric oxide (NO) as a signal for biofilm dispersal has been shown to increase the susceptibility of many biofilms to antibiotics, promoting their eradication. The delivery of NO to biofilms can be achieved by using NO-donors with different kinetics and properties of NO release that can influence their efficacy as biofilm control agents. In this study, the kinetics of three furoxan-derivatives were evaluated. The effects of these NO-donors, which have an advantageous pharmacological profile of slower onset with an extended duration of action, on Pseudomonas aeruginosa growth, biofilm development and dispersal were also characterized...
June 19, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28628240/comparative-transcriptome-analysis-of-nodules-of-two-mesorhizobium-chickpea-associations-with-differential-symbiotic-efficiency-under-phosphate-deficiency
#11
Maryam Nasr Esfahani, Komaki Inoue, Ha Duc Chu, Kien Huu Nguyen, Chien Van Ha, Yasuko Watanabe, David J Burritt, Luis Herrera-Estrella, Keiichi Mochida, Lam-Son Phan Tran
Phosphate (Pi) deficiency is known to be a major limitation for symbiotic nitrogen fixation (SNF), and hence legume crop productivity globally. However, very little information is available on the adaptive mechanisms, particularly in the important legume crop chickpea (Cicer arietinum L.), which enable nodules to respond to low-Pi availability. Thus, to elucidate these mechanisms in chickpea nodules at molecular level, we used an RNA sequencing approach to investigate transcriptomes of the nodules in Mesorhizobium mediterraneum SWRI9-(MmSWRI9)-chickpea and M...
June 19, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28628130/lipid-production-in-nannochloropsis-gaditana-is-doubled-by-decreasing-expression-of-a-single-transcriptional-regulator
#12
Imad Ajjawi, John Verruto, Moena Aqui, Leah B Soriaga, Jennifer Coppersmith, Kathleen Kwok, Luke Peach, Elizabeth Orchard, Ryan Kalb, Weidong Xu, Tom J Carlson, Kristie Francis, Katie Konigsfeld, Judit Bartalis, Andrew Schultz, William Lambert, Ariel S Schwartz, Robert Brown, Eric R Moellering
Lipid production in the industrial microalga Nannochloropsis gaditana exceeds that of model algal species and can be maximized by nutrient starvation in batch culture. However, starvation halts growth, thereby decreasing productivity. Efforts to engineer N. gaditana strains that can accumulate biomass and overproduce lipids have previously met with little success. We identified 20 transcription factors as putative negative regulators of lipid production by using RNA-seq analysis of N. gaditana during nitrogen deprivation...
June 19, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28628113/microrna-20a-mediated-loss-of-autophagy-contributes-to-breast-tumorigenesis-by-promoting-genomic-damage-and-instability
#13
L Liu, J He, X Wei, G Wan, Y Lao, W Xu, Z Li, H Hu, Z Hu, X Luo, J Wu, W Xie, Y Zhang, N Xu
Gene expression analysis of The Cancer Genome Atlas (TCGA) breast cancer data set show that miR-20a is upregulated in human breast cancer, especially in triple-negative subtype. Gene Set Enrichment Analysis suggests that miR-20a expression negatively correlates with the autophagy/lysosome pathway. We report here that miR-20a inhibits the basal and nutrient starvation-induced autophagic flux and lysosomal proteolytic activity, increases intracellular reactive oxygen species levels and DNA damage response by targeting several key regulators of autophagy, including BECN1, ATG16L1 and SQSTM1...
June 19, 2017: Oncogene
https://www.readbyqxmd.com/read/28627738/systematic-review-on-the-proteomic-profile-of-mycobacterium-tuberculosis-exposed-to-drugs
#14
REVIEW
Paula Aline Zanetti Campanerut-Sá, Luciana Dias Ghiraldi-Lopes, Jean Eduardo Meneguello, Jorge Juarez Vieira Teixeira, Regiane Bertin de Lima Scodro, Vera Lucia Dias Siqueira, Terezinha Inez Estivalet Svidzinski, Fernando Rogério Pavan, Rosilene Fressatti Cardoso
We present an over view about proteomics studies in Mycobacterium tuberculosis exposed to some anti-tuberculosis drugs and new candidates, using two-dimensional gel electrophoresis and mass spectrometry. To date, that we have knowledge, this is the first studies that was performed specifically in M. tuberculosis using systematic review on electronic literature conducted in three databases using the following search terms: tuberculosis OR mycobacterium tuberculosis, proteome OR proteomics, and mass spectrometry electrospray ionization OR matrix assisted laser desorption ionization OR two dimensional gel electrophoresis...
June 19, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28627726/the-arl3-and-arl1-gtpase-cooperates-with-cog8-to-regulate-selective-autophagy-via-atg9-trafficking
#15
I-Hao Wang, Yi-Jie Chen, Jia-Wei Hsu, Fang-Jen S Lee
The Arl3-Arl1 GTPase cascade plays important roles in vesicle trafficking at the late Golgi and endosomes. Subunits of the conserved oligomeric Golgi (COG) complex, a tethering factor, are important for endosome-to-Golgi transport and contribute to the efficient functioning of the cytoplasm-to-vacuole (Cvt) pathway, a well-known selective autophagy pathway. According to our findings, the Arl3-Arl1 GTPase cascade cooperates with Cog8 to regulate the Cvt pathway via Atg9 trafficking. arl3cog8Δ and arl1cog8Δ exhibit profound defects in aminopeptidase I maturation in rich medium...
June 19, 2017: Traffic
https://www.readbyqxmd.com/read/28627710/oil-and-eicosapentaenoic-acid-production-by-the-diatom-phaeodactylum-tricornutum-cultivated-outdoors-in-green-wall-panel-gwp%C3%A2-reactors
#16
Liliana Rodolfi, Natascia Biondi, Alessia Guccione, Niccolò Bassi, Massimo D'Ottavio, Gimena Arganaraz, Mario R Tredici
Phaeodactylum tricornutum is a widely studied diatom and has been proposed as a source of oil and polyunsaturated fatty acids (PUFA), particularly eicosapentaenoic acid (EPA). Recent studies indicate that lipid accumulation occurs under nutritional stress. Aim of this research was to determine how changes in nitrogen availability affect productivity, oil yield and fatty acid (FA) composition of P. tricornutum UTEX 640. After preliminary laboratory trials, outdoor experiments were carried out in 40-L GWP® reactors under different nitrogen regimes in batch...
June 19, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28627618/hypoxia-inducible-factor-1%C3%AE-regulates-autophagy-via-the-p27-e2f1-signaling-pathway
#17
Pan Wang, Meijing Long, Shijie Zhang, Zhenyun Cheng, Xin Zhao, Fucheng He, Hongchun Liu, Liang Ming
Autophagy is a highly conserved process by which the cell contents are delivered to lysosomes for degradation, or are used to provide macromolecules for energy generation under conditions of nutritional starvation. It has previously been demonstrated that cancer cells in hypoxic regions, with an oxygen concentration below the normal physiological level, express hypoxia inducible factor (HIF)‑1α, in order to adapt and survive. HIF‑1α is important in the regulation of oxygen homeostasis and the transcription of hundreds of genes in response to conditions of hypoxia, hence maintaining energy and redox homeostasis...
June 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28625967/rnase-ii-regulates-rnase-ph-and-is-essential-for-cell-survival-during-starvation-and-stationary-phase
#18
Shaheen Sulthana, Ernesto Quesada, Murray P Deutscher
RNase II is the most active exoribonuclease in Escherichia coli cell extracts. Yet, its removal appears to have no deleterious effect on growing cells. Here, we show that RNase II is required for cell survival during prolonged stationary phase and upon starvation. The absence of RNase II leads to greatly increased rRNA degradation and to the accumulation of rRNA fragments, both of which lead to a decline in cell survival. The deleterious effects of RNase II removal can be completely reversed by the simultaneous absence of a second exoribonuclease, RNase PH, an enzyme known to be required to initiate ribosome degradation in starving cells...
June 16, 2017: RNA
https://www.readbyqxmd.com/read/28625352/rna-seq-and-metabolic-flux-analysis-of-tetraselmis-sp-m8-during-nitrogen-starvation-reveals-a-two-stage-lipid-accumulation-mechanism
#19
David K Y Lim, Holger Schuhmann, Skye R Thomas-Hall, Kenneth C K Chan, Taylor J Wass, Felipe Aguilera, T Catalina Adarme-Vega, Cristiana G O Dal'Molin, Glen J Thorpe, Jacqueline Batley, David Edwards, Peer M Schenk
To map out key lipid-related pathways that lead to rapid triacylglyceride accumulation in oleaginous microalgae, RNA-Seq was performed with Tetraselmis sp. M8 at 24h after exhaustion of exogenous nitrogen to reveal molecular changes during early stationary phase. Further gene expression profiling by quantitative real-time PCR at 16-72h revealed a distinct shift in expression of the fatty acid/triacylglyceride biosynthesis and β-oxidation pathways, when cells transitioned from log-phase into early-stationary and stationary phase...
June 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28624766/dhea-protects-mitochondria-against-dual-modes-of-apoptosis-and-necroptosis-in-human-granulosa-ho23-cells
#20
Kuan-Hao Tsui, Peng-Hui Wang, Li-Te Lin, Chia-Jung Li
Because ovarian granulosa cells are essential for oocyte maturation and development, we validated human granulosa HO23 cells to evaluate the ability of the DHEA to prevent cell death after starvation. The present study was aimed to investigate whether DHEA could protect against starvation-induced apoptosis and necroptosis in human oocyte granulosa HO23 cells. The starvation was induced by treatment of serum-free (SF) medium for 4 h in vitro Starvation-induced mitochondrial depolarization, cytochrome c release and caspase-3 activation were largely prevented by DHEA in HO23 cells...
August 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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