Carmen Lanzillotti, Maria Rosa Iaquinta, Raffaella De Pace, Maria Mosaico, Simone Patergnani, Carlotta Giorgi, Marta Tavoni, Massimiliano Dapporto, Simone Sprio, Anna Tampieri, Monica Montesi, Fernanda Martini, Elisa Mazzoni
Osteosarcoma (OS) cancer treatments include systemic chemotherapy and surgical resection. In the last years, novel treatment approaches have been proposed, which employ a drug-delivery system to prevent offside effects and improves treatment efficacy. Locally delivering anticancer compounds improves on high local concentrations with more efficient tumour-killing effect, reduced drugs resistance and confined systemic effects. Here, the synthesis of injectable strontium-doped calcium phosphate (SrCPC) scaffold was proposed as drug delivery system to combine bone tissue regeneration and anticancer treatment by controlled release of methotrexate (MTX) and doxorubicin (DOX), coded as SrCPC-MTX and SrCPC-DOX, respectively...
April 9, 2024: Journal of Cellular Physiology