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hiv, sida

Pierre De Beaudrap, Gervais Beninguisse, Estelle Pasquier, Alice Tchoumkeu, Adonis Touko, Frida Essomba, Aude Brus, Toyin Janet Aderemi, Jill Hanass-Hancock, Arne Henning Eide, Muriel Mac-Seing, Daniel Mont
BACKGROUND: In resource-limited settings, people with disabilities have been left behind in the response to HIV. In the HandiVIH study, we estimate and compare HIV prevalence and associated risk factors between people with and without disabilities. METHODS: In this cross-sectional, population-based, observational study, we used two-phase random sampling to recruit adults with disabilities and a control group matched for age, sex, and residential location from households of the general population...
January 23, 2017: Lancet HIV
Jemma O'Connor, Michael J Vjecha, Andrew N Phillips, Brian Angus, David Cooper, Beatriz Grinsztejn, Gustavo Lopardo, Satyajit Das, Robin Wood, Aimee Wilkin, Hartwig Klinker, Pacharee Kantipong, Karin L Klingman, David Jilich, Elbushra Herieka, Eileen Denning, Ibrahim Abubakar, Fred Gordin, Jens D Lundgren
BACKGROUND: The effects of antiretroviral therapy on risk of severe bacterial infections in people with high CD4 cell counts have not been well described. In this study, we aimed to quantify the effects of immediate versus deferred ART on the risk of severe bacterial infection in people with high CD4 cell counts in a preplanned analysis of the START trial. METHODS: The START trial was a randomised controlled trial in ART-naive HIV-positive patients with CD4 cell count of more than 500 cells per μL assigned to immediate ART or deferral until their CD4 cell counts were lower than 350 cells per μL...
March 2017: Lancet HIV
Ken M Kunisaki, Dennis E Niewoehner, Gary Collins, Bitten Aagaard, Nafisah B Atako, Elzbieta Bakowska, Amanda Clarke, Giulio Maria Corbelli, Ernest Ekong, Sean Emery, Elizabeth B Finley, Eric Florence, Rosa M Infante, Cissy M Kityo, Juan Sierra Madero, Daniel E Nixon, Ellen Tedaldi, Jørgen Vestbo, Robin Wood, John E Connett
BACKGROUND: Observational data have been conflicted regarding the potential role of HIV antiretroviral therapy (ART) as a causative factor for, or protective factor against, COPD. We therefore aimed to investigate the effect of immediate versus deferred ART on decline in lung function in HIV-positive individuals. METHODS: We did a nested substudy within the randomised, controlled Strategic Timing of Antiretroviral Treatment (START) trial at 80 sites in multiple settings in 20 high-income and low-to-middle-income countries...
December 2016: Lancet Respiratory Medicine
F A Andoulo, M Kowo, G Ngatcha, A N Ndam, B Awouoyiegnigni, M B Sida, C Tzeuton, E C Ndjitoyap Ndam
OBJECTIVE: To determine the prevalence of Helicobacter pylori (H. pylori) infection and of various upper gastrointestinal (GI) lesions in HIV(+) patients with GI symptoms and the relation of H. pylori infection to CD4 cell counts. MATERIAL AND METHODS: In all, 56 HIV(+) patients and 56 age- and sex-matched HIV(-) controls, all with upper GI symptoms, were evaluated by an upper endoscopy examination and gastric biopsy. H. pylori status was assessed with a urease test and histology...
August 1, 2016: Médecine et Santé Tropicales
Gabriela Tavares Magnabosco, Lívia Maria Lopes, Rubia Laine de Paula Andrade, Maria Eugênia Firmino Brunello, Aline Aparecida Monroe, Tereza Cristina Scatena Villa
OBJECTIVE: to analyze the offering of health actions and services for the control of tuberculosis for people living with HIV/AIDS being followed up in the Specialized Care Services for HIV/AIDS in Ribeirão Preto, SP, Brazil. METHOD: quantitative, exploratory survey study. Participated 253 people living with HIV/AIDS followed up by this service, considering as inclusion criteria: individuals older than 18 years living in the city and not inmates. Data collection was conducted from January 2012 to May 2013 through interviews with the support of a specific instrument...
September 9, 2016: Revista Latino-americana de Enfermagem
P Feuillet, F Lert, L Tron, C Aubriere, B Spire, R Dray-Spira
OBJECTIVES: Depression is common among people living with HIV (PLWHIV) and is associated with poorer therapeutic outcomes and risky behaviours. We sought to estimate the prevalence of major depressive episode (MDE) across PLWHIV groups, to compare this with its prevalence in the general population and to assess factors associated with it. METHODS: We used data from the Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)-Vespa2 study, a national study on a representative sample of PLWHIV conducted in France in 2011...
September 14, 2016: HIV Medicine
Yesica Yolanda Rangel Flores
OBJECTIVE: to analyze the influence of sexual violence on the perception and management of the risk of HIV in women married to migrants. METHODS: study with an ethnographic approach carried out in urban and rural communities. Data were obtained by methodological triangulation, with participant and non-participant observation, as well as interviews. The informants were 21 women married to international migrants. The interviews were transcribed and discourse analysis was applied to them...
September 1, 2016: Revista Latino-americana de Enfermagem
Fatima Kakkar, Dimitri Van der Linden, Silvie Valois, Francois Maurice, Marion Onnorouille, Normand Lapointe, Hugo Soudeyns, Valerie Lamarre
BACKGROUND: Little is known on outcomes after transition to adult care among adolescents with perinatal HIV infection. Though there is data from other chronic pediatric diseases suggesting increased morbidity and mortality following transfer to adult care, this has not well been studied among the first wave of survivors of perinatal HIV infection. The primary objective of this study was to determine outcomes after transition to adult care among a cohort of HIV-infected adolescents in Québec, Canada...
2016: BMC Pediatrics
Elena Delgado-Mejía, Guillem Frontera-Juan, Javier Murillas-Angoiti, Antoni Abdon Campins-Roselló, Leire Gil-Alonso, María Peñaranda-Vera, María Angels Ribas Del Blanco, María Luisa Martín-Pena, Melchor Riera-Jaume
INTRODUCTION: In 2010, the AIDS Study Group (Grupo de Estudio del SIDA [GESIDA]) developed 66 quality care indicators. The aim of this study is to determine which of these indicators are associated with mortality and hospital admission, and to perform a preliminary assessment of a prediction rule for mortality and hospital admission in patients on treatment and follow-up. METHODS: A retrospective cohort study was conducted in the Hospital Universitario Son Espases (Palma de Mallorca, Spain)...
February 2017: Enfermedades Infecciosas y Microbiología Clínica
L Michel, C Lions, M Winnock, J-P Lang, M-A Loko, E Rosenthal, B Marchou, M-A Valantin, P Morlat, P Roux, P Sogni, B Spire, I Poizot-Martin, K Lacombe, C Lascoux-Combe, C Duvivier, D Neau, F Dabis, D Salmon-Ceron, M P Carrieri
OBJECTIVES: The objective of this nested study was to assess the prevalence of psychiatric disorders in a sample of HIV/hepatitis C virus (HCV)-coinfected patients according to their HCV status. METHODS: The nested cross-sectional study, untitled HEPAVIH-Psy survey, was performed in a subset of HIV/HCV-coinfected patients enrolled in the French Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS) CO13 HEPAVIH cohort. Psychiatric disorders were screened for using the Mini International Neuropsychiatric Interview (MINI 5...
May 17, 2016: HIV Medicine
Olivier Marcy, Vibol Ung, Sophie Goyet, Laurence Borand, Philippe Msellati, Mathurin Tejiokem, Ngoc Lan Nguyen Thi, Boubacar Nacro, Sokleaph Cheng, Sara Eyangoh, Thu Hang Pham, Abdoul-Salam Ouedraogo, Arnaud Tarantola, Sylvain Godreuil, Stéphane Blanche, Christophe Delacourt
BACKGROUND: The diagnosis of tuberculosis in human immunodeficiency virus (HIV)-infected children is challenging. We assessed the performance of alternative specimen collection methods for tuberculosis diagnosis in HIV-infected children using Xpert MTB/RIF (Xpert). METHODS: HIV-infected children aged ≤13 years with suspected intrathoracic tuberculosis were enrolled in 8 hospitals in Burkina Faso, Cambodia, Cameroon, and Vietnam. Gastric aspirates were taken for children aged <10 years and expectorated sputum samples were taken for children aged ≥10 years (standard samples); nasopharyngeal aspirate and stool were taken for all children, and a string test was performed if the child was aged ≥4 years (alternative samples)...
May 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
F Ankouane, D Noah Noah, M M Atangana, R Kamgaing Simo, P R Guekam, M Biwolé Sida
OBJECTIVES: Prevention of blood transfusion-transmitted infections includes blood donor screening and effective infectious markers screening for donated blood. This study had two main objectives: to determine seroprevalence of HBV, HCV, HIV and syphilis in blood donors of the Yaoundé Central Hospital and to study sociodemographic factors of blood donors. PATIENTS AND METHODS: A retrospective study of consecutive blood donors' records from January to December 2013 was conducted...
May 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Pierre Frange, Albert Faye, Véronique Avettand-Fenoël, Erianna Bellaton, Diane Descamps, Mathieu Angin, Annie David, Sophie Caillat-Zucman, Gilles Peytavin, Catherine Dollfus, Jerome Le Chenadec, Josiane Warszawski, Christine Rouzioux, Asier Sáez-Cirión
BACKGROUND: Durable HIV-1 remission after interruption of combined antiretroviral therapy (ART) has been reported in some adults who started treatment during primary infection; however, whether long-term remission in vertically infected children is possible was unknown. We report a case of a young adult perinatally infected with HIV-1 with viral remission despite long-term treatment interruption. METHODS: The patient was identified in the ANRS EPF-CO10 paediatric cohort among 100 children infected with HIV perinatally who started ART before 6 months of age...
January 2016: Lancet HIV
J A Mira, K Neukam, L F López-Cortés, A Rivero-Juárez, F Téllez, J A Girón-González, I de los Santos-Gil, G Ojeda-Burgos, D Merino, M J Ríos-Villegas, A Collado, A Torres-Cornejo, J Macías, A Rivero, M Pérez-Pérez, J A Pineda
The aim of this study was to assess the efficacy of and the risk of major bleeding during pegylated interferon (peg-IFN)/ribavirin (RBV) treatment among human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients according to the pretreatment platelet count. Two hundred and seventy-four HCV/HIV-coinfected, previously naïve individuals with compensated cirrhosis enrolled in one Spanish prospective cohort who received peg-IFN/RBV were included in this study. The frequency of severe bleeding and sustained virological response (SVR) rate were compared between patients with a pretreatment platelet count ≤70,000/mm(3) and >70,000/mm(3), respectively...
September 2015: European Journal of Clinical Microbiology & Infectious Diseases
Muhamadi Lubega, Nazarius Mbona Tumwesigye, Daniel Kadobera, Gaetano Marrone, Fred Wabwire-Mangen, Stefan Peterson, Steven J Reynolds, Anna Mia Ekström
BACKGROUND: Over 50% of people living with HIV (PLHIV) in sub-Saharan Africa are lost to follow-up between diagnosis and initiation of antiretroviral treatment during pre-antiretroviral (pre-ARV) care. The effect of providing home counseling visits by community support agents on 2-year retention in pre-ARV care was evaluated through a randomized controlled trial in eastern Uganda. METHODS: Four hundred newly screened HIV-positive patients were randomly assigned to receive posttest counseling alone (routine arm) or posttest counseling and monthly home counseling visits by community support agents to encourage them go back for routine pre-ARV care (intervention arm)...
October 1, 2015: Journal of Acquired Immune Deficiency Syndromes: JAIDS
José R Arribas, Pierre-Marie Girard, Roland Landman, Judit Pich, Josep Mallolas, María Martínez-Rebollar, Francisco X Zamora, Vicente Estrada, Manuel Crespo, Daniel Podzamczer, Joaquín Portilla, Fernando Dronda, José A Iribarren, Pere Domingo, Federico Pulido, Marta Montero, Hernando Knobel, André Cabié, Laurence Weiss, José M Gatell
BACKGROUND: Our objective was to assess therapeutic non-inferiority of dual treatment with lopinavir-ritonavir and lamivudine to triple treatment with lopinavir-ritonavir plus two nucleos(t)ides for maintenance of HIV-1 viral suppression. METHODS: In this randomised, open-label, non-inferiority trial, we recruited patients from 32 HIV units in hospitals in Spain and France. Eligible patients were HIV-infected adults (aged ≥18 years) with HIV-1 RNA of less than 50 copies per mL, for at least 6 months on triple treatment with lopinavir-ritonavir (twice daily) plus lamivudine or emtricitabine and a second nucleos(t)ide, with no resistance or virological failure to these drugs, and no positive hepatitis B serum surface antigen...
July 2015: Lancet Infectious Diseases
Fatima Kakkar, Isabelle Boucoiran, Valerie Lamarre, Thierry Ducruet, Devendra Amre, Hugo Soudeyns, Normand Lapointe, Marc Boucher
BACKGROUND: The risk of pre-term birth (PTB) associated with the use of protease inhibitors (PIs) during pregnancy remains a subject of debate. Recent data suggest that ritonavir boosting of PIs may play a specific role in the initiation of PTB, through an effect on the maternal-fetal adrenal axis. The primary objective of this study is to compare the risk of PTB among women treated with boosted PI versus non-boosted PIs during pregnancy. METHODS: Between 1988 and 2011, 705 HIV-positive women were enrolled into the Centre Maternel et Infantile sur le SIDA mother-infant cohort at Centre Hospitalier Universitaire Sainte-Justine in Montreal, Canada...
2015: Journal of the International AIDS Society
Charles Cazanave, Sandrine Reigadas, Cyril Mazubert, Pantxika Bellecave, Mojgan Hessamfar, Fabien Le Marec, Estibaliz Lazaro, Gilles Peytavin, Mathias Bruyand, Hervé Fleury, François Dabis, Didier Neau
Background.  The purpose of this study was to assess the efficacy and tolerability of combined antiretroviral therapy (cART) in human immunodeficiency virus (HIV)-1 virologically suppressed patients who switched to rilpivirine (RPV)/tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) as a single-tablet regimen (STR). Methods.  A retrospective multicenter cohort study was performed between September 2012 and February 2014 in Bordeaux University Hospital-affiliated clinics. Patients with a plasma HIV viral load (VL) lower than 50 copies/mL and switching to STR were evaluated at baseline, 3, 6, 9, and 12 months from switch time (M3, M6, M9, M12) for VL and other biological parameters...
January 2015: Open Forum Infectious Diseases
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No abstract text is available yet for this article.
March 2015: Canadian Journal of Infectious Diseases & Medical Microbiology
Mélanie Bertine, Charlotte Charpentier, Benoit Visseaux, Alexandre Storto, Gilles Collin, Lucile Larrouy, Florence Damond, Sophie Matheron, Françoise Brun-Vézinet, Diane Descamps
OBJECTIVE: In HIV-1, hypermutation introduced by APOBEC3F/3G cytidine deaminase activity leads to defective viruses. In-vivo impact of APOBEC3F/3G editing on HIV-2 sequences remains unknown. The objective of this study was to assess the level of APOBEC3F/3G editing in HIV-2-infected antiretroviral-naive patients. METHODS: Direct sequencing of vif and pol regions was performed on HIV-2 proviral DNA from antiretroviral-naive patients included in the French Agence Nationale de Recherches sur le SIDA et les hépatites virales CO5 HIV-2 cohort...
April 24, 2015: AIDS
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