keyword
https://read.qxmd.com/read/38534979/serum-pro-inflammatory-cytokines-and-leptin-as-potential-biomarkers-for-treatment-response-and-toxicity-in-locally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#1
JOURNAL ARTICLE
Amani A Alrehaili, Amal F Gharib, Maha M Bakhuraysah, Afaf Alharthi, Ohud Alsalmi, Fouzeyyah Ali Alsaeedi, Reem Ali Alhakami, Kamilah Ali Alasmari, Nuha Mohammed, Wael H Elsawy
Squamous cell carcinoma of the head and neck (HNSCC) is a globally prevalent form of cancer with significant morbidity and mortality rates. The present study examines the relationship of serum pro-inflammatory cytokines and leptin levels with the effectiveness of therapy in individuals with HNSCC and their potential role as biomarkers for treatment response and toxicity. Induction chemotherapy and concomitant chemoradiotherapy were evaluated for efficacy and safety in 52 individuals with HNSCC. Both response and toxicity were evaluated, and serum levels of pro-inflammatory cytokines Interlukin-1 beta (IL-1β), Interlukin-2 (IL-2), Interlukin-6 (IL-6), and Tumor Necrosis Factor-Alpha (TNF-α) and leptin were measured using enzyme-linked immunoassay before and after treatment...
March 11, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534754/effects-of-chronic-sleep-restriction-on-transcriptional-sirtuin-1-signaling-regulation-in-male-mice-white-adipose-tissue
#2
JOURNAL ARTICLE
Marco Rendine, Paolo Cocci, Luisa de Vivo, Michele Bellesi, Francesco Alessandro Palermo
Chronic sleep restriction (CSR) is a prevalent issue in modern society that is associated with several pathological states, ranging from neuropsychiatric to metabolic diseases. Despite its known impact on metabolism, the specific effects of CSR on the molecular mechanisms involved in maintaining metabolic homeostasis at the level of white adipose tissue (WAT) remain poorly understood. Therefore, this study aimed to investigate the influence of CSR on sirtuin 1 (SIRT1) and the peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway in the WAT of young male mice...
March 7, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533785/gut-motility-and-hormone-changes-after-bariatric-procedures
#3
JOURNAL ARTICLE
Khushboo Gala, Wissam Ghusn, Barham K Abu Dayyeh
PURPOSE OF REVIEW: Metabolic and bariatric surgery (MBS) and endoscopic bariatric therapies (EBT) are being increasingly utilized for the management of obesity. They work through multiple mechanisms, including restriction, malabsorption, and changes in the gastrointestinal hormonal and motility. RECENT FINDINGS: Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG) cause decrease in leptin, increase in GLP-1 and PYY, and variable changes in ghrelin (generally thought to decrease)...
March 28, 2024: Current Opinion in Endocrinology, Diabetes, and Obesity
https://read.qxmd.com/read/38533595/effect-of-leptin-on-nitrergic-neurons-in-the-lateral-hypothalamic-area-and-the-supraoptic-nucleus-of-rats
#4
JOURNAL ARTICLE
Milen Hristov, Boycho Landzhov, Krassimira Yakimova
The adipocyte-derived hormone, leptin, plays a key role in the maintenance of energy homeostasis. Leptin binds to the long form of its receptor, which is predominantly expressed in various hypothalamic regions, including the lateral hypothalamic area (LH) and supraoptic nucleus (SO). Several studies have suggested that leptin directly activates neuronal nitric oxide synthase, leading to increased nitric oxide production. We used histochemistry for nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) as a marker for nitric oxide synthase activity and assessed the effect of leptin on nitrergic neurons in the LH and SO of rats...
March 27, 2024: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://read.qxmd.com/read/38531961/author-correction-the-adipokine-leptin-modulates-adventitial-pericyte-functions-by-autocrine-and-paracrine-signalling
#5
Federica Riu, Sadie C Slater, Eva Jover Garcia, Iker Rodriguez-Arabaolaza, Valeria Alvino, Elisa Avolio, Giuseppe Mangialardi, Andrea Cordaro, Simon Satchell, Carlo Zebele, Andrea Caporali, Gianni Angelini, Paolo Madeddu
No abstract text is available yet for this article.
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38530155/post-weaning-social-isolation-modifies-neonatal-anoxia-induced-changes-in-energy-metabolism-and-growth-of-rats
#6
JOURNAL ARTICLE
Natalia Andrea Cruz-Ochoa, Lívia Clemente Motta-Teixeira, Pablo Felipe Cruz-Ochoa, Santiago Lopez-Paredes, Julieta Esperanza Ochoa-Amaya, Silvia Honda Takada, Gilberto Fernando Xavier, Maria Inês Nogueira
Neonatal oxygen deficiency in rats may disturb growth and long-term metabolic homeostasis. In order to facilitate metabolic evaluation, the subjects are usually housed individually. However, social isolation associated with individually housed conditions alters animal behavior, which may influence the experimental results. This study investigated the effects of social isolation on neonatal anoxia-induced changes in growth and energy metabolism. Male and female Wistar rats were exposed, on postnatal day 2 (P2), to either 25-min of anoxia or control treatment...
March 26, 2024: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38530139/fenretinide-in-young-women-at-genetic-or-familial-risk-of-breast-cancer-a-placebo-controlled-biomarker-trial
#7
JOURNAL ARTICLE
Valentina Aristarco, Davide Serrano, Patrick Maisonneuve, Aliana Guerrieri-Gonzaga, Matteo Lazzeroni, Irene Feroce, Debora Macis, Elena Cavadini, Elena Albertazzi, Costantino Jemos, Emanuela Omodeo Salè, Laura Cortesi, Samuele Massarut, Marcella Gulisano, Maria Grazia Daidone, Harriet Johansson, Bernardo Bonanni
Fenretinide, a retinoid with a low toxicity profile that accumulates in the breast, has been shown to prevent second breast cancer in young women. Fenretinide exhibits apoptotic and anti-invasive properties and it improves insulin sensitivity in overweight premenopausal women with insulin resistance. The present study aimed to further characterize its role in cancer prevention by measuring circulating biomarkers related to insulin sensitivity and breast cancer risk. Sixty-two women, aged 20 to 46 years, healthy or who had already undergone breast cancer surgery, with a known BRCA1/2 mutation or a likelihood of mutation ≥ 20% according to the BRCAPRO model, were randomly assigned to receive fenretinide (200 mg/day) or placebo for 5 years (trial registration: EudraCT Number: 2009-010260-41)...
March 26, 2024: Cancer Prevention Research
https://read.qxmd.com/read/38529946/patterns-of-sleep-duration-and-metabolic-biomarkers-across-the-menstrual-cycle
#8
JOURNAL ARTICLE
Galit Levi Dunietz, Kerby Shedden, Xiru Lyu, Ronald D Chervin, Ana Baylin, Louise M O'Brien, Erica C Jansen, Jean Wactawski-Wende, Enrique F Schisterman, Sunni L Mumford
CONTEXT: Along the menstrual cycle, associations between inconsistent sleep duration and levels of metabolic biomarkers are uncertain and could involve fluctuations in estrogen concentrations. OBJECTIVE: To examine associations between patterns of sleep duration and metabolic biomarkers across two menstrual cycles within a cohort of premenopausal women. METHODS: The BioCycle Study was conducted in New York between 2005-2007, enrolling 259 premenopausal women over two menstrual cycles...
March 26, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38528095/effects-of-prenatal-thc-vapor-exposure-on-body-weight-glucose-metabolism-and-feeding-behaviors-in-chow-and-high-fat-diet-fed-rats
#9
JOURNAL ARTICLE
Catherine Hume, Samantha L Baglot, Lucia Javorcikova, Savannah H M Lightfoot, Jessica Scheufen, Matthew N Hill
BACKGROUND: 4-20% of people report using cannabis during pregnancy, thereby it is essential to assess the associated risks. There is some evidence that prenatal cannabis exposure (PCE) may be associated with increased risk for developing of obesity and diabetes later in life, however this has not been well explored under controlled conditions. The aim of this study was to use a translational THC vapor model in rodents to characterize the effects of PCE on adiposity, glucose metabolism, and feeding patterns in adulthood, with focus on potential sex differences...
March 25, 2024: International Journal of Obesity
https://read.qxmd.com/read/38528040/unexpected-identification-of-obesity-associated-mutations-in-lep-and-mc4r-genes-in-patients-with-anorexia-nervosa
#10
JOURNAL ARTICLE
Luisa Sophie Rajcsanyi, Yiran Zheng, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stephan Zipfel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Föcker, Jochen Antel, Pamela Fischer-Posovszky, Johannes Hebebrand, Anke Hinney
Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system confer a risk for monogenic forms of obesity. Yet, gain of function variants in the melanocortin-4-receptor (MC4R) gene predispose to a lower BMI. In individuals with reduced body weight, we thus expected mutations leading to an enhanced function in the respective genes, like leptin (LEP) and MC4R. Therefore, we have Sanger sequenced the coding regions of LEP and MC4R in 462 female patients with anorexia nervosa (AN), and 445 healthy-lean controls...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527636/the-effect-of-a-combined-lifestyle-intervention-with-and-without-protein-drink-on-inflammation-in-older-adults-with-obesity-and-type-2-diabetes
#11
JOURNAL ARTICLE
Robert G Memelink, Rose Njemini, Minse J J de Bos Kuil, Suzan Wopereis, Johan de Vogel-van den Bosch, Josje D Schoufour, Michael Tieland, Peter J M Weijs, Ivan Bautmans
BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D. METHODS: In this post-hoc analysis of the PROBE study 114 adults (≥55 years) with obesity and type 2 (pre-)diabetes had measurements of C-reactive protein (CRP), pro-inflammatory cytokines interleukin (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte chemoattractant protein (MCP)-1, anti-inflammatory cytokines IL-10, IL-1 receptor antagonist (RA), and soluble tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) and soluble receptor for advanced glycation end products (sRAGE) from fasting blood samples...
March 23, 2024: Experimental Gerontology
https://read.qxmd.com/read/38526590/effect-of-indian-gooseberry-extract-on-improving-methylglyoxal-associated-leptin-resistance-in-peripheral-tissues-of-high-fat-diet-fed-rats
#12
JOURNAL ARTICLE
Sheng-Yi Chen, Yue-Ning Huang, Jer-An Lin, Gow-Chin Yen
Increased leptin resistance and methylglyoxal (MG) levels are observed in obese patients. However, whether MG deposits contribute to leptin resistance, oxidative stress, and inflammation in peripheral tissues remains unclear. In addition, the edible fruit of Indian gooseberry (Phyllanthus emblica L.) contains abundant bioactive components such as vitamin C, β-glucogallin (β-glu), gallic acid (GA), and ellagic acid (EA). Water extract of Indian gooseberry fruit (WEIG) and GA has been shown to improve cognitive decline by suppressing brain MG-induced insulin resistance in rats administered a high-fat diet (HFD)...
March 15, 2024: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38525541/adipose-transplantation-improves-metabolism-and-atherosclerosis-but-not-pvat-abnormality-or-vascular-dysfunction-in-lipodystrophic-seipin-apoe-null-mice
#13
JOURNAL ARTICLE
Zhe Meng, Chuangxing Liu, Mengke Xu, Yongqiang Tao, Haiyu Li, Xijia Wang, Jiawei Liao, Mengyu Wang
Adipose dysfunction in lipodystrophic SEIPIN deficiency is associated with multiple metabolic disorders and increased risks of developing cardiovascular diseases, such as atherosclerosis, cardiac hypertrophy, and heart failure. Recently, adipose transplantation is found to correct adipose dysfunction and metabolic disorders in lipodystrophic Seipin knockout mice; however, whether adipose transplantation could improve lipodystrophy-associated cardiovascular consequences is still unclear. Here, we aimed to explore the effects of adipose transplantation on lipodystrophy-associated metabolic cardiovascular diseases in Seipin knockout mice crossed into atherosclerosis-prone apolipoprotein E ( Apoe ) knockout background...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38524938/higher-childhood-weight-gain-lower-skeletal-muscle-mass-and-higher-cereal-consumption-in-normal-weight-japanese-women-with-high-percentage-trunk-fat-a-subanalysis-study
#14
JOURNAL ARTICLE
Satomi Minato-Inokawa, Mari Honda, Ayaka Tsuboi-Kaji, Mika Takeuchi, Kaori Kitaoka, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
Normal-weight but high-percentage trunk fat phenotype was characterized in a setting where adiposity is not associated with educational and socioeconomic status. Body size trajectory since birth, current body composition measured using whole-body dual-energy X-ray absorptiometry, cardiometabolic traits, serum adipokines, and dietary intake were measured cross-sectionally in 251 normal weight Japanese female university students whose fasting triglyceride and homeostasis model assessment-insulin resistance (HOMA-IR) averaged 56 mg/dL and 1...
April 2024: Diabetology International
https://read.qxmd.com/read/38524924/influence-of-diet-and-body-weight-in-treatment-resistant-acquired-partial-lipodystrophy-after-hematopoietic-stem-cell-transplantation-and-its-potential-for-metabolic-improvement
#15
Emi Ishida, Kazuhiko Horiguchi, Shunichi Matsumoto, Atsushi Ozawa, Sho Sekiguchi, Eijiro Yamada
Lipodystrophy is a rare disease characterized by various metabolic complications resulting from the complete or partial loss of adipose tissues and abnormal fat accumulation. Acquired lipodystrophy may occur due to certain drugs, autoimmunity or for unknown reasons. Recently, cases of acquired lipodystrophy after hematopoietic stem cell transplantation (HSCT) have been reported. Leptin administration, used recently to treat generalized lipodystrophy, effectively controlled metabolic complications; however, few reports demonstrated the effectiveness of leptin for acquired partial lipodystrophy...
April 2024: Diabetology International
https://read.qxmd.com/read/38524608/zhuang-gu-fang-intervenes-vasculogenic-and-osteogenic-coupling-in-gk-rats-through-notch1-noggin-vegf-pathway
#16
JOURNAL ARTICLE
Xinyan Jin, Yuyu Sun, Rui Bai, Jun Shi, Linna Zhai, Yunxia Jiang, Mengchun Jiang, Jiali He, Junyu Li, Ting Wang, Shuanglei Li, Wenhui Chen
BACKGROUND: Zhuang-Gu-Fang (ZGF) has been proved to treat osteoporosis in ovariectomized rats by increasing osteogenic related factors Leptin, Ghrelin and Peptide YY(PYY). However, the mechanism of ZGF in the treatment of diabetic osteoporosis (DOP) remains unclear. The aim of this study was to explore the therapeutic effect of ZGF on DOP and its potential molecular mechanism. METHODS: Using GK rats as models, the pharmacodynamic effects of ZGF on bone loss were evaluated by hematoxylin-eosin (H&E) staining and micro-computed...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524370/trans-omic-analysis-reveals-opposite-metabolic-dysregulation-between-feeding-and-fasting-in-liver-associated-with-obesity
#17
JOURNAL ARTICLE
Yunfan Bai, Keigo Morita, Toshiya Kokaji, Atsushi Hatano, Satoshi Ohno, Riku Egami, Yifei Pan, Dongzi Li, Katsuyuki Yugi, Saori Uematsu, Hiroshi Inoue, Yuka Inaba, Yutaka Suzuki, Masaki Matsumoto, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Dysregulation of liver metabolism associated with obesity during feeding and fasting leads to the breakdown of metabolic homeostasis. However, the underlying mechanism remains unknown. Here, we measured multi-omics data in the liver of wild-type and leptin-deficient obese ( ob / ob ) mice at ad libitum feeding and constructed a differential regulatory trans-omic network of metabolic reactions. We compared the trans-omic network at feeding with that at 16 h fasting constructed in our previous study. Intermediate metabolites in glycolytic and nucleotide metabolism decreased in ob / ob mice at feeding but increased at fasting...
March 15, 2024: IScience
https://read.qxmd.com/read/38524240/differentiation-of-placenta-derived-mscs-cultured-in-human-platelet-lysate-a-xenofree-supplement
#18
JOURNAL ARTICLE
Merlin Sobia Poomani, Rathika Regurajan, Ramachandran Perumal, Aravindhakshan Ramachandran, Iyyadurai Mariappan, Krishnaveni Muthan, Venkatesh Subramanian
In the last few decades, mesenchymal stem cells (MSCs)-based regenerative therapies in clinical applications have gradually become a hot topic due to their long-term self-renewal and multilineage differentiation ability. In this scenario, placenta (p) has been considered as a good source of MSCs. As a tissue of fetal origin with abundant number of stem cells compared to other sources, their non-invasive acquisition, strong immunosuppression, and lack of ethical concerns make placenta an indispensable source of MSC in stem cell research and therapy...
April 2024: 3 Biotech
https://read.qxmd.com/read/38522074/the-arg-arg-genotype-of-leptin-receptor-gene-gln223arg-polymorphism-may-be-an-independent-risk-factor-for-nonalcoholic-fatty-liver-disease
#19
JOURNAL ARTICLE
Mahsa Navari, Fatemeh Zarei, Shiva Sayedsalehi, Touraj Mahmoudi, Mitra Rostami, Aidin Mahban, Gholamreza Rezamand, Asadollah Asadi, Reza Dabiri, Hossein Nobakht, Hamid Farahani, Seidamir Pasha Tabaeian, Mohammad Reza Zali
BACKGROUND: Given that obesity and insulin resistance play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and the connection between leptin and these metabolic diseases, the association between NAFLD and a leptin receptor gene (LEPR) polymorphism was examined. METHODS: In this genetic case-control association study, 144 biopsy-proven NAFLD patients and 144 controls were genotyped for the LEPR gene Gln223Arg (rs1137101) polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method...
March 24, 2024: Laboratory Medicine
https://read.qxmd.com/read/38519567/protein-tyrosine-phosphatase-1b-in-metabolic-diseases-and-drug-development
#20
REVIEW
Mirela Delibegović, Sergio Dall'Angelo, Ruta Dekeryte
Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signalling pathways, including direct negative regulation of classic insulin and leptin signalling pathways, and is implicated in the pathogenesis of several cardiometabolic diseases and cancers. As such, PTP1B has been a therapeutic target for over two decades, with PTP1B inhibitors identified either from natural sources or developed throughout the years. Some of these inhibitors have reached phase I and/or II clinical trials in humans for the treatment of type 2 diabetes mellitus, obesity and/or metastatic breast cancer...
March 22, 2024: Nature Reviews. Endocrinology
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