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Nazanin Ebrahimiadib, Bobeck S Modjtahedi, Ramak Roohipoor, Stephen D Anesi, C Stephen Foster
PURPOSE: Management of granulomatosis with polyangiitis (GPA)-associated peripheral ulcerative keratitis (PUK) is challenging and lacks definite guidelines. We aimed to summarize our treatment and outcome experience with patients with GPA-PUK. METHODS: The Massachusetts Eye Research and Surgery Institution patient database was searched from 2005 to 2015 to identify patients with diagnosis of PUK who suffered from GPA. Individual patient histories were examined, and treatment strategies and outcomes were summarized...
June 29, 2016: Cornea
Lau Brix, Steffen Ringgaard, Puk Sandager, Olav Bjørn Petersen, Thomas Sangild Sørensen, Erik Lundorf, Brian Stausbøl-Grøn
OBJECTIVE: Foetal MRI has become an established image modality in the prenatal diagnosis of CNS anomalies, but image quality can be severely affected by foetal movements. The objective was to overcome these inherent motion problems by applying interactive real-time MRI and to evaluate the diagnostic usefulness of the applied real-time MRI sequence in relation to standard protocols. METHODS: Ten healthy foetuses (gestation week 21·3 ± 0·5) were scanned using a system, which allowed visual feedback and interactive slice positioning in real time...
March 22, 2016: Clinical Physiology and Functional Imaging
Dagmara Stepień-Pyśniak, Krzysztof Puk, Leszek Guz, Agata Wawrzyniak, Agnieszka Marek, Urszula Kosikowska
Avian tuberculosis, one of the most important diseases affecting various species of birds, is most often caused by Mycobacterium (M.) avium. This report describes cases of M. avium subsp. avium (MAA) infection in a white-crested Holland dwarf rooster, a male and a female golden pheasant and a male peacock. We also investigated the prevalence of mycobacteria in 60 other birds and 40 alpacas. Tissue samples of necropsied birds were cultured for mycobacteria. From non-necropsied 60 other birds and alpacas only faecal samples were collected...
January 2016: Berliner und Münchener Tierärztliche Wochenschrift
Tarun Arora, Namrata Sharma, Adarsh Shashni, Jeewan S Titiyal
A 16-year-old girl presented with pain, redness, watering, and blurring of vision in her right eye. Slit lamp examination revealed the presence of peripheral ulcerative keratitis (PUK) and nodular scleritis. On clinical examination, the patient had stunted growth, low body mass index, and enlarged axillary nodes. Giardia cysts were present in the stool sample and histopathology of axillary lymph nodes showed caseating necrosis suggestive of tuberculosis (TB). A diagnosis of PUK with chronic malabsorption syndrome secondary to giardiasis and miliary TB was made...
September 2015: Oman Journal of Ophthalmology
Bryn M Burkholder, Irene C Kuo
PURPOSE: We report a case of a patient with a history of glomerulonephropathy, not disclosed prior to laser in situ keratomileusis (LASIK), who developed severe postoperative peripheral ulcerative keratitis (PUK) soon after surgery. METHOD: Case report. RESULTS: Within a week of surgery, the patient, who had no blepharitis or ocular surface disease, also developed diffuse lamellar keratitis (DLK) that was not contiguous with the PUK. Microbiologic evaluation of the flap interface disclosed no organisms, and no epithelial ingrowth was found...
January 2016: Case Reports in Ophthalmology
Cheng-Wei Lu, Dan-Dan Zhou, Jiao Wang, Ji-Long Hao
The efficacy of surgical management of refractory ophthalmic complications of granulomatosis with polyangiitis (GPA), which is a sight threatening was reported. A 70-year-old man presented with a progressively worsening pain and redness in his right eye during the previous 6 months, and decreasing visual acuity that started one month earlier. He was misdiagnosed and treated as keratitis elsewhere, but the pain has not decreased. The diagnosis of necrotizing scleritis with peripheral ulcerative keratitis (PUK) in GPA was made in our department...
February 2016: Saudi Medical Journal
Yong Yao Chun, Jun Kit Wang, Nguan Soon Tan, Peggy Puk Yik Chan, Timothy Thatt Yang Tan, Cleo Choong
A 3D injectable hydrogel-bioceramic composite consisting of gelatin-3-(4-hydroxyphenyl) propionic acid (Gtn-HPA) and carboxymethyl cellulose-tyramine (CMC-Tyr), incorporated with fish scale-derived calcium phosphate (CaP), is developed for bone applications. The hydrogel-bioceramic composite has significantly improved the elastic modulus compared to the non-filled hydrogel, of which the addition of 10 w/v% CaP showed zero order fluorescein isothiocyanate (FITC)-dextran release profile and a significantly higher proliferation rate of encapsulated cells...
February 2016: Macromolecular Bioscience
Séverine Marcos, Monica González-Lázaro, Leonardo Beccari, Laura Carramolino, Maria Jesus Martin-Bermejo, Oana Amarie, Daniel Mateos-San Martín, Carlos Torroja, Ozren Bogdanović, Roisin Doohan, Oliver Puk, Martin Hrabě de Angelis, Jochen Graw, Jose Luis Gomez-Skarmeta, Fernando Casares, Miguel Torres, Paola Bovolenta
Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual deficits of variable degree. Sporadic and hereditary microphthalmos have been associated with heterozygous mutations in genes fundamental for eye development. Yet, many cases are idiopathic or await the identification of molecular causes. Here we show that haploinsufficiency of Meis1, which encodes a transcription factor with evolutionarily conserved expression in the embryonic trunk, brain and sensory organs, including the eye, causes microphthalmic traits and visual impairment in adult mice...
September 1, 2015: Development
Martin Hrabě de Angelis, George Nicholson, Mohammed Selloum, Jacqueline K White, Hugh Morgan, Ramiro Ramirez-Solis, Tania Sorg, Sara Wells, Helmut Fuchs, Martin Fray, David J Adams, Niels C Adams, Thure Adler, Antonio Aguilar-Pimentel, Dalila Ali-Hadji, Gregory Amann, Philippe André, Sarah Atkins, Aurelie Auburtin, Abdel Ayadi, Julien Becker, Lore Becker, Elodie Bedu, Raffi Bekeredjian, Marie-Christine Birling, Andrew Blake, Joanna Bottomley, Michael R Bowl, Véronique Brault, Dirk H Busch, James N Bussell, Julia Calzada-Wack, Heather Cater, Marie-France Champy, Philippe Charles, Claire Chevalier, Francesco Chiani, Gemma F Codner, Roy Combe, Roger Cox, Emilie Dalloneau, André Dierich, Armida Di Fenza, Brendan Doe, Arnaud Duchon, Oliver Eickelberg, Chris T Esapa, Lahcen El Fertak, Tanja Feigel, Irina Emelyanova, Jeanne Estabel, Jack Favor, Ann Flenniken, Alessia Gambadoro, Lilian Garrett, Hilary Gates, Anna-Karin Gerdin, George Gkoutos, Simon Greenaway, Lisa Glasl, Patrice Goetz, Isabelle Goncalves Da Cruz, Alexander Götz, Jochen Graw, Alain Guimond, Wolfgang Hans, Geoff Hicks, Sabine M Hölter, Heinz Höfler, John M Hancock, Robert Hoehndorf, Tertius Hough, Richard Houghton, Anja Hurt, Boris Ivandic, Hughes Jacobs, Sylvie Jacquot, Nora Jones, Natasha A Karp, Hugo A Katus, Sharon Kitchen, Tanja Klein-Rodewald, Martin Klingenspor, Thomas Klopstock, Valerie Lalanne, Sophie Leblanc, Christoph Lengger, Elise le Marchand, Tonia Ludwig, Aline Lux, Colin McKerlie, Holger Maier, Jean-Louis Mandel, Susan Marschall, Manuel Mark, David G Melvin, Hamid Meziane, Kateryna Micklich, Christophe Mittelhauser, Laurent Monassier, David Moulaert, Stéphanie Muller, Beatrix Naton, Frauke Neff, Patrick M Nolan, Lauryl M J Nutter, Markus Ollert, Guillaume Pavlovic, Natalia S Pellegata, Emilie Peter, Benoit Petit-Demoulière, Amanda Pickard, Christine Podrini, Paul Potter, Laurent Pouilly, Oliver Puk, David Richardson, Stephane Rousseau, Leticia Quintanilla-Fend, Mohamed M Quwailid, Ildiko Racz, Birgit Rathkolb, Fabrice Riet, Janet Rossant, Michel Roux, Jan Rozman, Edward Ryder, Jennifer Salisbury, Luis Santos, Karl-Heinz Schäble, Evelyn Schiller, Anja Schrewe, Holger Schulz, Ralf Steinkamp, Michelle Simon, Michelle Stewart, Claudia Stöger, Tobias Stöger, Minxuan Sun, David Sunter, Lydia Teboul, Isabelle Tilly, Glauco P Tocchini-Valentini, Monica Tost, Irina Treise, Laurent Vasseur, Emilie Velot, Daniela Vogt-Weisenhorn, Christelle Wagner, Alison Walling, Marie Wattenhofer-Donze, Bruno Weber, Olivia Wendling, Henrik Westerberg, Monja Willershäuser, Eckhard Wolf, Anne Wolter, Joe Wood, Wolfgang Wurst, Ali Önder Yildirim, Ramona Zeh, Andreas Zimmer, Annemarie Zimprich, Chris Holmes, Karen P Steel, Yann Herault, Valérie Gailus-Durner, Ann-Marie Mallon, Steve D M Brown
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power...
September 2015: Nature Genetics
Sandra Viering, Matthias Jäger, Carlos Nordt, Franziska Bühler, Bettina Bärtsch, Hansjörg Leimer, Peter Sommerfeld, Wulf Rössler, Wolfram Kawohl
This study aims to investigate clients' satisfaction with individual placement and support (IPS) at the University Hospital for Psychiatry Zurich (PUK). Furthermore, this study aims to investigate if clients feel the approach of IPS as a useful approach to fulfill their needs. One hundred twenty-five people were recruited from one of the three IPS services of PUK and were asked to complete a structured questionnaire. The following IPS services were available: (i) randomized controlled trial (RCT) ZHEPP (www...
2015: Frontiers in Public Health
Sarah Kunze, Claudia Dalke, Helmut Fuchs, Matthias Klaften, Ute Rössler, Sabine Hornhardt, Maria Gomolka, Oliver Puk, Sibylle Sabrautzki, Ulrike Kulka, Martin Hrabě de Angelis, Jochen Graw
Cataracts are the major eye disorder and have been associated mainly with mutations in lens-specific genes, but cataracts are also frequently associated with complex syndromes. In a large-scale high-throughput ENU mutagenesis screen we analyzed the offspring of paternally treated C3HeB/FeJ mice for obvious dysmorphologies. We identified a mutant suffering from rough coat and small eyes only in homozygotes; homozygous females turned out to be sterile. The mutation was mapped to chromosome 7 between the markers 116J6...
2015: PloS One
Namrata Sharma, Gautam Sinha, Himanshu Shekhar, Jeewan S Titiyal, Tushar Agarwal, Bhavna Chawla, Radhika Tandon, Rasik B Vajpayee
PURPOSE: To evaluate aetiology, demographic profile, clinical features and outcomes in cases of peripheral ulcerative keratitis (PUK). METHODS: Seventy-six eyes of 65 consecutive patients with PUK were evaluated in this prospective interventional study over an 18 month period, which were followed for 3 years. The main outcome measures were sociodemographic profile, aetiology, clinical features, management strategies and outcome. RESULTS: Sixty per cent (39/65) of cases were men and mean age was 45...
November 2015: British Journal of Ophthalmology
Fabrízzio Condé de Oliveira, Carlos Cristiano Hasenclever Borges, Fernanda Nascimento Almeida, Fabyano Fonseca e Silva, Rui da Silva Verneque, Marcos Vinicius G B da Silva, Wagner Arbex
INTRODUCTION: This paper proposes a new methodology to simultaneously select the most relevant SNPs markers for the characterization of any measurable phenotype described by a continuous variable using Support Vector Regression with Pearson Universal kernel as fitness function of a binary genetic algorithm. The proposed methodology is multi-attribute towards considering several markers simultaneously to explain the phenotype and is based jointly on statistical tools, machine learning and computational intelligence...
2014: BMC Genomics
Valentín Huerva, Francisco J Ascaso, Andrzej Grzybowski
Biologic agents such as anti-TNFα have been employed in treatment paradigms for ocular inflammation. Peripheral corneal ulceration (PUK) is a devastating disorder consisting of a crescent-shaped area of destructive inflammation at the margin of the corneal stroma. It is associated with an epithelial defect, the presence of stromal inflammatory cells, and progressive stromal degradation and thinning, leading to ocular perforation and devastating visual loss. Macroulcerative PUK is usually a local manifestation of a systemic vasculitis...
November 2014: Medicine (Baltimore)
Benjamin Knier, Veit Rothhammer, Sylvia Heink, Oliver Puk, Jochen Graw, Bernhard Hemmer, Thomas Korn
Optic neuritis is a common inflammatory manifestation of multiple sclerosis (MS). In experimental autoimmune encephalomyelitis (EAE), the optic nerve is affected as well. Here, we investigated whether autoimmune inflammation in the optic nerve is distinct from inflammation in other parts of the central nervous system (CNS). In our study, inflammatory infiltrates in the optic nerve and the brain were characterized by a high fraction of Ly6G(+) granulocytes whereas in the spinal cord, macrophage infiltrates were predominant...
January 2015: Journal of Autoimmunity
Alfonso Iovieno, Seema Anand, John K Dart
PURPOSE: To report delayed-onset peripheral ulcerative keratitis (PUK) following alkali injury. DESIGN: Retrospective case series. METHODS: setting: Single institution (Cornea and External Disease Service, Moorfields Eye Hospital). participants: Six eyes of 5 patients with PUK and associated anterior scleritis that had a history of ocular alkali injury. observationprocedure: Patients were identified among PUK patients seen at Moorfields Eye Hospital over a 20-year period...
December 2014: American Journal of Ophthalmology
B J Schmitz-Dräger, S Sahin, G Lümmen, E Bismarck, C Fischer
Through the last decade considerations on the role of vitamins and antioxidants in the primary prevention of genitourinary tumors have changed dramatically. In spite of all efforts, the efficacy of a specific compound has not been proven so far. In consequence, recommendations to use vitamins or other supplements for the primary prevention of urological tumors should be avoided. However, there is some evidence that moderate food consumption, reduction of dairy products and an Asian or Mediterranean diet may not only prevent prostate cancer (PCA) but also harbour additional beneficial effects on general health...
July 2014: Aktuelle Urologie
Anette T Hansen, Puk Sandager, Niels Uldbjerg, Anne-Mette Hvas
OBJECTIVE: To investigate copeptin as a biomarker for small-for-gestational-age. METHODS: We conducted a nested case-control study on maternal copeptin levels measured in gestational week 12 and 19 and risk of small-for-gestational age. Cases were defined as pregnant women who delivered a small-for-gestational-age infant. Small-for-gestational age was defined as a birth weight - 22% or less than expected according to gestational age (n = 39). Controls were pregnant women who delivered a normal-weight infant (n = 119)...
November 2014: Scandinavian Journal of Clinical and Laboratory Investigation
Petra Kraus, Sivakamasundari V, Hong Bing Yu, Xing Xing, Siew Lan Lim, Thure Adler, Juan Antonio Aguilar Pimentel, Lore Becker, Alexander Bohla, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Eva Janas, Kristin Moreth, Cornelia Prehn, Oliver Puk, Birgit Rathkolb, Jan Rozman, Jerzy Adamski, Raffi Bekeredjian, Dirk H Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Frauke Neff, Markus Ollert, Tobias Stoeger, Ali Önder Yildrim, Oliver Eickelberg, Eckhard Wolf, Wolfgang Wurst, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Thomas Lufkin, Lawrence W Stanton
The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof...
2014: PloS One
Donghua Liao, Lene Hee, Puk Sandager, Niels Uldbjerg, Hans Gregersen
BACKGROUND AND AIMS: The course and outcome of pregnancy is closely correlated to change of biomechanical properties of the uterine cervix. The aim of this study was to build a non-linear, fiber reinforced mechanical model of the cervix for estimation of mechanical characteristics of the cervix in early- and term-pregnant women based on recordings of in vivo pressure and diameter by means of the Functional Luminal Imaging Probe (FLIP) technology. MATERIALS AND METHODS: Five early- and six term-pregnant women were examined with a FLIP probe...
November 2014: Journal of the Mechanical Behavior of Biomedical Materials
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