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Brown adipose oxygen consumption

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https://www.readbyqxmd.com/read/27895388/acetate-alters-expression-of-genes-involved-in-beige-adipogenesis-in-3t3-l1-cells-and-obese-kk-ay-mice
#1
Satoko Hanatani, Hiroyuki Motoshima, Yuki Takaki, Shuji Kawasaki, Motoyuki Igata, Takeshi Matsumura, Tatsuya Kondo, Takafumi Senokuchi, Norio Ishii, Junji Kawashima, Daisuke Kukidome, Seiya Shimoda, Takeshi Nishikawa, Eiichi Araki
The induction of beige adipogenesis within white adipose tissue, known as "browning", has received attention as a novel potential anti-obesity strategy. The expression of some characteristic genes including PR domain containing 16 is induced during the browning process. Although acetate has been reported to suppress weight gain in both rodents and humans, its potential effects on beige adipogenesis in white adipose tissue have not been fully characterized. We examined the effects of acetate treatment on 3T3-L1 cells and in obese diabetic KK-Ay mice...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27876792/mtorc1-is-required-for-brown-adipose-tissue-recruitment-and-metabolic-adaptation-to-cold
#2
Sébastien M Labbé, Mathilde Mouchiroud, Alexandre Caron, Blandine Secco, Elizaveta Freinkman, Guillaume Lamoureux, Yves Gélinas, Roger Lecomte, Yohan Bossé, Patricia Chimin, William T Festuccia, Denis Richard, Mathieu Laplante
In response to cold, brown adipose tissue (BAT) increases its metabolic rate and expands its mass to produce heat required for survival, a process known as BAT recruitment. The mechanistic target of rapamycin complex 1 (mTORC1) controls metabolism, cell growth and proliferation, but its role in regulating BAT recruitment in response to chronic cold stimulation is unknown. Here, we show that cold activates mTORC1 in BAT, an effect that depends on the sympathetic nervous system. Adipocyte-specific mTORC1 loss in mice completely blocks cold-induced BAT expansion and severely impairs mitochondrial biogenesis...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873458/resveratrol-enhances-brown-adipocyte-formation-and-function-by-activating-amp-activated-protein-kinase-ampk-%C3%AE-1-in-mice-fed-high-fat-diet
#3
Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B D Rodgers, Qingyan Jiang, Michael V Dodson, Min Du
SCOPE: Enhancing the formation and function of brown adipose tissue (BAT) increases thermogenesis and hence reduces obesity. Thus, we investigate the effects of resveratrol (Resv) on brown adipocyte formation and function in mouse interscapular BAT (iBAT). METHODS AND RESULTS: CD1 mice and stromal vascular cells (SVCs) isolated from iBAT were treated with Resv. Expression of brown adipogenic and thermogenic markers, and involvement of AMP-activated protein kinase (AMPK)α1 were assessed...
November 22, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27824128/deletion-of-lkb1-in-adult-mice-results-in-body-weight-reduction-and-lethality
#4
Tizhong Shan, Yan Xiong, Shihuan Kuang
Liver kinase B1 (Lkb1) plays crucial roles in development, metabolism and survival. As constitutive knockout of Lkb1 in mice leads to embryonic lethality, whether Lkb1 is required for the growth and survival of adult mice is unclear. Here we address this question using a tamoxifen-inducible Lkb1 knockout (KO) mouse model: Rosa26-Cre(ER): Lkb1(flox/flox) (abbreviated as Rosa-Lkb1). The Rosa-Lkb1 mice exhibited body weight reduction and died within 6 weeks after tamoxifen induction. The body weight reduction was due to reduced weight of various tissues but the brown and white adipose tissues underwent much more pronounced weight reduction relative to the overall body weight reduction...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27789721/sympathetic-innervation-of-cold-activated-brown-and-white-fat-in-lean-young-adults
#5
Otto Muzik, Thomas J Mangner, William R Leonard, Ajay Kumar, James G Granneman
OBJECTIVE: Recent work in rodents has demonstrated that basal activity of local sympathetic nervous system is critical for maintaining brown adipocyte phenotypes in classic brown (BAT) and white adipose tissue (WAT). Accordingly, we sought to assess the relationship between sympathetic innervation and cold-induced activation of BAT and WAT, and its relation to local and whole body daily energy expenditure (DEE, kcal/d) in lean young adults. METHODS: Twenty adult lean normal subjects (10F/10M, 23...
October 27, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27754258/os-36-09-deficiency-of-thermogenesis-and-heat-sensation-accelerates-obesity-and-high-blood-pressure
#6
Yuanting Cui, Li Li, Peng Gao, Liqun Ma, Daoyan Liu, Zhiming Zhu
OBJECTIVE: Obesity is global healthy problem. Uncoupling protein 1 (UCP1) mainly expresses on brown adipose tissue (BAT), uncouples energy substrate oxidation from mitochondrial ATP production and results in the loss of potential energy as heat. Transient receptor potential vanilloid subfamily, member 1 (TRPV1) is the heat-gated cation ion channel. The aim of this study was to investigate the in vivo role of TRPV1 and UCP1 co-action in obesity. DESIGN AND METHOD: We generated and characterized UCP1 mice lacking TRPV1 activity (TRPV1/UCP1 mice)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748422/seipin-deficiency-alters-brown-adipose-tissue-thermogenesis-and-insulin-sensitivity-in-a-non-cell-autonomous-mode
#7
L Dollet, J Magré, M Joubert, C Le May, A Ayer, L Arnaud, C Pecqueur, V Blouin, B Cariou, X Prieur
Loss-of-function mutations in BSCL2 are responsible for Berardinelli-Seip congenital lipodystrophy, a rare disorder characterized by near absence of adipose tissue associated with insulin resistance. Seipin-deficient (Bscl2(-/-)) mice display an almost total loss of white adipose tissue (WAT) with residual brown adipose tissue (BAT). Previous cellular studies have shown that seipin deficiency alters white adipocyte differentiation. In this study, we aimed to decipher the consequences of seipin deficiency in BAT...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27740871/brown-adipose-tissue-function-is-enhanced-in-long-lived-male-ames-dwarf-mice
#8
Justin Darcy, Samuel McFadden, Yimin Fang, Joshua A Huber, Chi Zhang, Liou Y Sun, Andrzej Bartke
Ames dwarf mice (Prop1(df/df)) are long-lived due to a loss of function mutation, resulting in deficiency of GH, TSH, and prolactin. Along with a marked extension of longevity, Ames dwarf mice have improved energy metabolism as measured by an increase in their oxygen consumption and heat production, as well as a decrease in their respiratory quotient. Along with alterations in energy metabolism, Ames dwarf mice have a lower core body temperature. Moreover, Ames dwarf mice have functionally altered epididymal white adipose tissue (WAT) that improves, rather than impairs, their insulin sensitivity due to a shift from pro- to anti-inflammatory cytokine secretion...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27738746/adipose-hif-1%C3%AE-causes-obesity-by-suppressing-brown-adipose-tissue-thermogenesis
#9
Jonathan C Jun, Ronald Devera, Dileep Unnikrishnan, Mi-Kyung Shin, Shannon Bevans-Fonti, Qiaoling Yao, Aman Rathore, Haris Younas, Nils Halberg, Philipp E Scherer, Vsevolod Y Polotsky
: Hypoxia-inducible factor-1α (HIF-1α) in adipose tissue is known to promote obesity. We hypothesized that HIF-1α interferes with brown fat thermogenesis, thus decreasing energy expenditure. To test this hypothesis, we compared transgenic mice constitutively expressing HIF-1α in adipose tissues (HIF-1α++) at usual temperature (22 °C), where brown fat is somewhat active, or at thermoneutrality (30 °C), where brown fat is minimally active. HIF-1α++ mice or control litter mates were separated into room temperature (22 °C) or thermoneutrality (30 °C) groups...
October 14, 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/27733447/pharmacologic-activation-of-estrogen-receptor-%C3%AE-increases-mitochondrial-function-energy-expenditure-and-brown-adipose-tissue
#10
Suriyan Ponnusamy, Quynh T Tran, Innocence Harvey, Heather S Smallwood, Thirumagal Thiyagarajan, Souvik Banerjee, Daniel L Johnson, James T Dalton, Ryan D Sullivan, Duane D Miller, Dave Bridges, Ramesh Narayanan
Most satiety-inducing obesity therapeutics, despite modest efficacy, have safety concerns that underscore the need for effective peripherally acting drugs. An attractive therapeutic approach for obesity is to optimize/maximize energy expenditure by increasing energy-utilizing thermogenic brown adipose tissue. We used in vivo and in vitro models to determine the role of estrogen receptor β (ER-β) and its ligands on adipose biology. RNA sequencing and metabolomics were used to determine the mechanism of action of ER-β and its ligands...
October 12, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27684068/deficiency-of-interleukin-15-confers-resistance-to-obesity-by-diminishing-inflammation-and-enhancing-the-thermogenic-function-of-adipose-tissues
#11
Gregory Lacraz, Volatiana Rakotoarivelo, Sebastien M Labbé, Mathieu Vernier, Christophe Noll, Marian Mayhue, Jana Stankova, Adel Schwertani, Guillaume Grenier, André Carpentier, Denis Richard, Gerardo Ferbeyre, Julie Fradette, Marek Rola-Pleszczynski, Alfredo Menendez, Marie-France Langlois, Subburaj Ilangumaran, Sheela Ramanathan
OBJECTIVE: IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exercise by skeletal muscle and has been reported to reduce weight gain in mice. Contrarily, our findings on IL-15 knockout (KO) mice indicate that IL-15 promotes obesity. The aim of this study is to investigate the mechanisms underlying the pro-obesity role of IL-15 in adipose tissues. METHODS: Control and IL-15 KO mice were maintained on high fat diet (HFD) or normal control diet...
2016: PloS One
https://www.readbyqxmd.com/read/27670404/metabolic-programming-of-a-beige-adipocyte-phenotype-by-genistein
#12
Sadat A Aziz, Luisa A Wakeling, Satomi Miwa, Goiuri Alberdi, John E Hesketh, Dianne Ford
Promoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice. We observed that application of genistein to 3T3-L1 adipocytes changed the lipid distribution from large droplets to a multilocular distribution, reduced mRNAs indicative of white adipocytes (ACC, Fasn, Fabp4, HSL, chemerin and resistin) and increased mRNAs that are a characteristic feature of brown/beige adipocytes (CD-137 and UCP1)...
September 27, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27643223/os-36-09-deficiency-of-thermogenesis-and-heat-sensation-accelerates-obesity-and-high-blood-pressure
#13
Yuanting Cui, Li Li, Peng Gao, Liqun Ma, Daoyan Liu, Zhiming Zhu
OBJECTIVE: Obesity is global healthy problem. Uncoupling protein 1 (UCP1) mainly expresses on brown adipose tissue (BAT), uncouples energy substrate oxidation from mitochondrial ATP production and results in the loss of potential energy as heat. Transient receptor potential vanilloid subfamily, member 1 (TRPV1) is the heat-gated cation ion channel. The aim of this study was to investigate the in vivo role of TRPV1 and UCP1 co-action in obesity. DESIGN AND METHOD: We generated and characterized UCP1 mice lacking TRPV1 activity (TRPV1/UCP1 mice)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27554471/salsalate-salicylate-uncouples-mitochondria-improves-glucose-homeostasis-and-reduces-liver-lipids-independent-of-ampk-%C3%AE-1
#14
Brennan K Smith, Rebecca J Ford, Eric M Desjardins, Alex E Green, Meghan C Hughes, Vanessa P Houde, Emily A Day, Katarina Marcinko, Justin D Crane, Emilio P Mottillo, Christopher G R Perry, Bruce E Kemp, Mark A Tarnopolsky, Gregory R Steinberg
Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces non-alcoholic fatty liver disease (NAFLD) in animal models; however, the mechanism mediating these effects is unclear. Salicylate directly activates AMP-activated protein kinase (AMPK) via the β1 subunit but whether salsalate requires AMPK β1 to improve T2D and NAFLD has not been examined. Therefore, wild-type (WT) and AMPK β1 knockout mice (AMPK β1KO) were treated with a salsalate dose resulting in clinically relevant serum salicylate concentrations (∼1 mM)...
August 23, 2016: Diabetes
https://www.readbyqxmd.com/read/27534841/mitochondria-targeted-dodecyltriphenylphosphonium-c12tpp-combats-high-fat-diet-induced-obesity-in-mice
#15
A V Kalinovich, C L Mattsson, M R Youssef, N Petrovic, M Ost, V P Skulachev, I G Shabalina
BACKGROUND: A membrane-penetrating cation, dodecyltriphenylphosphonium (C12TPP), facilitates the recycling of fatty acids in the artificial lipid membrane and mitochondria. C12TPP can dissipate mitochondrial membrane potential and may affect total energy expenditure and body weight in animals and humans. METHODS: We investigated the metabolic effects of C12TPP in isolated brown-fat mitochondria, brown adipocyte cultures and mice in vivo. Experimental approaches included the measurement of oxygen consumption, carbon dioxide production, Western blotting, magnetic resonance imaging and bomb calorimetry...
August 18, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27486903/white-adipose-tissue-browning-in-the-r6-2-mouse-model-of-huntington-s-disease
#16
Andrew C McCourt, Lovisa Jakobsson, Sara Larsson, Cecilia Holm, Sarah Piel, Eskil Elmér, Maria Björkqvist
Huntington's disease (HD) is a fatal, autosomal dominantly inherited neurodegenerative disorder, characterised not only by progressive cognitive, motor and psychiatric impairments, but also of peripheral pathology. In both human HD and in mouse models of HD there is evidence of increased energy expenditure and weight loss, alongside altered body composition. Unlike white adipose tissue (WAT), brown adipose tissue (BAT), as well as brown-like cells within WAT, expresses the mitochondrial protein, uncoupling protein 1 (UCP1)...
2016: PloS One
https://www.readbyqxmd.com/read/27409675/sex-specific-metabolic-interactions-between-liver-and-adipose-tissue-in-mcd-diet-induced-non-alcoholic-fatty-liver-disease
#17
Yun-Hee Lee, Sou Hyun Kim, Sang-Nam Kim, Hyun-Jung Kwon, Jeong-Dong Kim, Ji Youn Oh, Young-Suk Jung
Higher susceptibility to metabolic disease in male exemplifies the importance of sexual dimorphism in pathogenesis. We hypothesized that the higher incidence of non-alcoholic fatty liver disease in males involves sex-specific metabolic interactions between liver and adipose tissue. In the present study, we used a methionine-choline deficient (MCD) diet-induced fatty liver mouse model to investigate sex differences in the metabolic response of the liver and adipose tissue. After 2 weeks on an MCD-diet, fatty liver was induced in a sex-specific manner, affecting male mice more severely than females...
July 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27377953/dietary-luteolin-activates-browning-and-thermogenesis-in-mice-through-an-ampk-pgc1%C3%AE-pathway-mediated-mechanism
#18
X Zhang, Q-X Zhang, X Wang, L Zhang, W Qu, B Bao, C-A Liu, J Liu
BACKGROUND: Two brown-like adipocytes, including classical brown adipocytes from brown adipose tissues and beige cells from white adipose tissues, regulate thermogenesis. The developmental and functional induction of brown-like cells provides a defense against obesity and associated metabolic diseases. Our previous study suggests dietary luteolin can improve diet-induced obesity and insulin resistance in mice. Here we further elucidated the action of the natural flavonoid on energy expenditure and adaptive thermogenesis...
July 5, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27356800/-effect-of-sirt1-deficiency-on-function-of-brown-adipose-tissue-in-obese-mice
#19
X B Zheng, H Y Ai, S H Yuan, H Y Cao, H Liang, J P Weng, F Xu
OBJECTIVE: To investigate the effect of silent mating type information regulation 2 homolog 1 (SIRT1) deficiency on function of brown adipose tissue (BAT) in high-fat diet (HFD)-induced obese mice. METHODS: Male SIRT1 deficient heterozygous (SIRT1(+ /-)) mice and their wild-type (WT) littermates were challenged with a HFD diet for 16 weeks to induce obesity model.Energy metabolic cages were used to measure oxygen consumption and heat production, and cold tolerance test was to evaluate the adaptive thermogenic function...
June 21, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27345691/let-7i-5p-represses-brite-adipocyte-function-in-mice-and-humans
#20
Maude Giroud, Michael Karbiener, Didier F Pisani, Rayane A Ghandour, Guillaume E Beranger, Tarja Niemi, Markku Taittonen, Pirjo Nuutila, Kirsi A Virtanen, Dominique Langin, Marcel Scheideler, Ez-Zoubir Amri
In response to cold or β3-adrenoreceptor stimulation brown adipose tissue (BAT) promotes non-shivering thermogenesis, leading to energy dissipation. BAT has long been thought to be absent or scarce in adult humans. The recent discovery of thermogenic brite/beige adipocytes has opened the way to development of novel innovative strategies to combat overweight/obesity and associated diseases. Thus it is of great interest to identify regulatory factors that govern the brite adipogenic program. Here, we carried out global microRNA (miRNA) expression profiling on human adipocytes to identify miRNAs that are regulated upon the conversion from white to brite adipocytes...
2016: Scientific Reports
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