keyword
MENU ▼
Read by QxMD icon Read
search

Lymphoma AND miRNA

keyword
https://www.readbyqxmd.com/read/29328474/inhibition-of-mir%C3%A2-34a-prevents-endothelial-cell-apoptosis-by-directly-targeting-hdac1-in-the-setting-of-atherosclerosis
#1
Yangwei Li, Kang Zhang, Wei Mao
Despite recent medical advances, atherosclerosis is a global burden accounting for numerous mortalities and hospital admissions. MicroRNAs (miRNAs/miRs) regulate cardiovascular biology and disease, but the role of microRNA‑34a in atherosclerosis remains unclear. In the present study, it was demonstrated that miR‑34a was highly expressed in atherosclerotic lesions and oxidized low‑density lipoprotein (Ox‑LDL)‑treated human aortic endothelial cells (HAECs) (atherosclerotic cell model) using reverse transcription‑quantitative polymerase chain reaction...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328455/role-of-mir-21-in-the-growth-and-metastasis-of-human-salivary-adenoid-cystic-carcinoma
#2
Fei Yan, Chao Wang, Ting Li, Wenyan Cai, Jinhu Sun
Aberrant microRNA (miRNA/miR) expression has been reported in various cancer types. miR‑21, which is considered to be a proto-oncogene and is frequently overexpressed in certain cancer types, has been implicated in tumorigenesis. The aim of the present study was to investigate the effect of miR‑21 degradation on tumor progression and its potential mechanisms in human salivary adenoid cystic carcinoma (SACC) development. Results of reverse transcription‑quantitative polymerase chain reaction analysis indicated that SACC cells with high metastatic potential (SACC‑LM cells) exhibited a significantly higher expression of miR‑21 compared with SACC cells with a lower metastatic potential (SACC‑83 cells)...
January 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29305594/egbmmda-extreme-gradient-boosting-machine-for-mirna-disease-association-prediction
#3
Xing Chen, Li Huang, Di Xie, Qi Zhao
Associations between microRNAs (miRNAs) and human diseases have been identified by increasing studies and discovering new ones is an ongoing process in medical laboratories. To improve experiment productivity, researchers computationally infer potential associations from biological data, selecting the most promising candidates for experimental verification. Predicting potential miRNA-disease association has become a research area of growing importance. This paper presents a model of Extreme Gradient Boosting Machine for MiRNA-Disease Association (EGBMMDA) prediction by integrating the miRNA functional similarity, the disease semantic similarity, and known miRNA-disease associations...
January 5, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29296171/micrornas-sequencing-unveils-distinct-molecular-subgroups-of-plasmablastic-lymphoma
#4
Maria Raffaella Ambrosio, Lucia Mundo, Sara Gazaneo, Matteo Picciolini, Prasad Satya Vara, Shaheen Sayed, Alessandro Ginori, Giuseppe Lo Bello, Leonardo Del Porro, Mohsen Navari, Stefano Ascani, Amhed Yonis, Lorenzo Leoncini, Pier Paolo Piccaluga, Stefano Lazzi
Plasmablastic lymphoma (PBL) is an aggressive lymphoma, often arising in the context of immunodeficiency and associated with Epstein-Barr virus (EBV) infection. The most frequently detected genetic alteration is the deregulation of MYC gene through the translocation - t(8;14)(q24;q32). The diagnosis of PBL is often challenging because it has an overlap in morphology, immunophenotype, cytogenetics and virus association with other lymphomas and plasma cell neoplasms; further, its molecular basis remains elusive...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29286137/microrna-124a-inhibits-cell-proliferation-and-migration-in-liver-cancer-by-regulating-interleukin-11
#5
Liedao Yu, Shuo Wang, Xiangjin Lin, Yang Lu, Pengcheng Gu
Liver cancer is the sixth most common malignant tumour and ranks in the top three cancers with regard to mortality due to metastasis and postsurgical recurrence. It is significant to understand the mechanisms underlying liver cancer for diagnosis and treatment. Cumulative evidence suggests that the abnormal regulation of microRNAs (miRNAs/miRs) may contribute to the development and metastasis of cancer. miR‑124a acts as a tumour suppressor in osteosarcoma, endometrial carcinoma, prostate cancer, and glioblastoma...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29284789/activating-and-sustaining-c-myc-by-depletion-of-mir-144-451-gene-locus-contributes-to-b-lymphomagenesis
#6
Lan Ding, Yanqing Zhang, Lingling Han, Lei Fu, Xia Mei, Jijun Wang, Jacobi Itkow, Afaf Elabid Ibrahim Elabid, Lei Pang, Duonan Yu
Hyper activity of protooncogene c-Myc is one of the hallmarks of highly aggressive lymphomas. However, the mechanism of how c-Myc is subjected to activation and amplification is still not well defined. In this study, we use gene knockout strategy to show that targeted depletion of a well-conserved microRNA gene locus miR-144/451 initiates tumorigenesis including B-lymphoma development in aged mice. This is due, at least in part, to the direct activation of the c-Myc gene by loss of miR-144/451 expression in hematopoietic cells...
December 29, 2017: Oncogene
https://www.readbyqxmd.com/read/29242506/micrornas-regulate-key-cell-survival-pathways-and-mediate-chemosensitivity-during-progression-of-diffuse-large-b-cell-lymphoma
#7
Suvi-Katri Leivonen, Katherine Icay, Kirsi Jäntti, Ilari Siren, Chengyu Liu, Amjad Alkodsi, Alejandra Cervera, Maja Ludvigsen, Stephen Jacques Hamilton-Dutoit, Francesco d'Amore, Marja-Liisa Karjalainen-Lindsberg, Jan Delabie, Harald Holte, Rainer Lehtonen, Sampsa Hautaniemi, Sirpa Leppä
Despite better therapeutic options and improved survival of diffuse large B-cell lymphoma (DLBCL), 30-40% of the patients experience relapse or have primary refractory disease with a dismal prognosis. To identify biological correlates for treatment resistance, we profiled microRNAs (miRNAs) of matched primary and relapsed DLBCL by next-generation sequencing. Altogether 492 miRNAs were expressed in the DLBCL samples. Thirteen miRNAs showed significant differential expression between primary and relapse specimen pairs...
December 15, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/29233191/mkrmda-multiple-kernel-learning-based-kronecker-regularized-least-squares-for-mirna-disease-association-prediction
#8
Xing Chen, Ya-Wei Niu, Guang-Hui Wang, Gui-Ying Yan
BACKGROUND: Recently, as the research of microRNA (miRNA) continues, there are plenty of experimental evidences indicating that miRNA could be associated with various human complex diseases development and progression. Hence, it is necessary and urgent to pay more attentions to the relevant study of predicting diseases associated miRNAs, which may be helpful for effective prevention, diagnosis and treatment of human diseases. Especially, constructing computational methods to predict potential miRNA-disease associations is worthy of more studies because of the feasibility and effectivity...
December 12, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29208599/prognostic-mirna-classifier-in-early-stage-mycosis-fungoides-development-and-validation-in-a-danish-nationwide-study
#9
Lise M Lindahl, Søren Besenbacher, Anne H Rittig, Pamela Celis, Andreas Willerslev-Olsen, Lise M R Gjerdrum, Thorbjørn Krejsgaard, Claus Johansen, Thomas Litman, Anders Woetmann, Niels Odum, Lars Iversen
Mycosis fungoides (MF) is the most frequent form of cutaneous T-cell lymphoma. The disease often takes an indolent course, but in approximately one third of the patients, the disease progresses to an aggressive malignancy with a poor prognosis. At the time of diagnosis, it is impossible to predict which patients develop severe disease and are in need of aggressive treatment. Accordingly, we investigated the prognostic potential of microRNAs (miRNAs) at the time of diagnosis in MF. Using a qRT-PCR platform, we analysed miRNA expression in diagnostic skin biopsies from 154 Danish patients with early-stage MF...
December 5, 2017: Blood
https://www.readbyqxmd.com/read/29207012/microrna%C3%A2-30a%C3%A2-5p-suppresses-tumor-cell-proliferation-of-human-renal-cancer-via-the-mtdh-pten-akt-pathway
#10
Jianmin Li, Changying Li, Hongjie Li, Ting Zhang, Xiaodong Hao, Jiwu Chang, Yong Xu
The present study aimed to explore the effects of microRNA (miRNA)‑30a‑5p on tumor proliferation and to seek a potential therapeutic target for the treatment of human renal cancer. The results demonstrated that the expression levels of miRNA‑30a‑5p were reduced in tumor samples from patients with renal cancer compared with in normal tissue samples. Overall survival and disease‑free survival were increased in patients with renal cancer and high miRNA‑30a‑5p expression compared with in those with low miRNA‑30a‑5p...
November 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29185784/mir-21-inhibitors-modulate-biological-functions-of-gastric-cancer-cells-via-pten-pi3k-mtor-pathway
#11
Ping Wang, Qunye Guan, Dongmei Zhou, Ze Yu, Yaobo Song, Wensheng Qiu
Gastric cancer is one of the most common malignancy in the world. microRNAs (miRNAs) are naturally occurring noncoding RNA that control gene expression by targeting messenger RNA (mRNA) for post-transcriptional repression or cleavage. This study focused on a specific miRNA, miR-21, which was overexpressed in gastric cancer and examined the effects of miR-21 inhibitor on biological functions of gastric cancer cells and its possible mechanism. Gastric cancer cells MKN74 were treated with miR-21 inhibitor, negative control, and blank control...
November 29, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29179212/luks-pv-regulated-microrna-125a-3p-promotes-thp-1-macrophages-differentiation-and-apoptosis-by-down-regulating-nf1-and-bcl-2
#12
Xiao-Xi Sun, Shan-Shan Zhang, Chun-Yang Dai, Jing Peng, Qing Pan, Liang-Fei Xu, Xiao-Ling Ma
BACKGROUND/AIMS: LukS-PV is a component of Panton-Valentine leukocidin (PVL). We have previously demonstrated that LukS-PV potently promoted differentiation and induced apoptosis in THP-1 cells. However, the precise mechanisms of these actions remain unknown. MicroRNAs (miRs) play important roles in cellular differentiation and apoptosis. This study aimed to investigate the role of miR-125a-3p in LukS-PV-regulated differentiation and apoptosis and its underlying mechanism in THP-1 cells...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29158064/mirna-223-functions-as-both-prognostic-biomarker-and-tumor-suppressor-in-mantle-cell-lymphoma-through-targeting-sox11
#13
REVIEW
Keshu Zhou, Xiaoyan Feng, Yanying Wang, Yanyan Liu, Long Tian, Wenli Zuo, Shuhua Yi, Xudong Wei, Yongping Song, Lugui Qiu
Mantle cell lymphoma (MCL) is an aggressive lymphoid malignance characterized by cytogenetic aberration of t(11;14), although it is not the prerequisite. Until now, the pathogenesis of MCL remains not fully interpreted. Our current study showed that miR-223 was down-regulated in purified CD19+ lymphocytes from MCL patients (n=21) compared with that of normal donors (n=20). In addition, patients with high-risk mantle international prognostic index, elevated LDH, performance status>2 were more likely to have much lower miR-223 expression...
November 17, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/29156774/micrornas-as-predictors-for-cns-relapse-of-systemic-diffuse-large-b-cell-lymphoma
#14
Nir Pillar, Osnat Bairey, Neta Goldschmidt, Yakov Fellig, Yevgenia Rosenblat, Itchak Shehtman, Danielle Haguel, Pia Raanani, Noam Shomron, Tali Siegal
Systemic diffuse large B-cell lymphoma (DLBCL) is a potentially curable disease using current regimen of immunochemotherapy. Central nervous system (CNS) relapse is a complication that occurs in approximately 5% of DLBCL patients and is associated with a high fatality rate. Early identification of molecular markers for CNS involvement may serve for the highly needed accurate stratification of patients into risk groups regarding CNS relapse. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level and are known to be involved in DLBCL pathophysiology...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156742/prmda-personalized-recommendation-based-mirna-disease-association-prediction
#15
Zhu-Hong You, Luo-Pin Wang, Xing Chen, Shanwen Zhang, Xiao-Fang Li, Gui-Ying Yan, Zheng-Wei Li
Recently, researchers have been increasingly focusing on microRNAs (miRNAs) with accumulating evidence indicating that miRNAs serve as a vital role in various biological processes and dysfunctions of miRNAs are closely related with human complex diseases. Predicting potential associations between miRNAs and diseases is attached considerable significance in the domains of biology, medicine, and bioinformatics. In this study, we developed a computational model of Personalized Recommendation-based MiRNA-Disease Association prediction (PRMDA) to predict potential related miRNA for all diseases by implementing personalized recommendation-based algorithm based on integrated similarity for diseases and miRNAs...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135973/hdac6-regulates-microrna-27b-that-suppresses-proliferation-promotes-apoptosis-and-target-met-in-diffuse-large-b-cell-lymphoma
#16
Y J Jia, Z B Liu, W G Wang, C B Sun, P Wei, Y L Yang, M J You, B H Yu, X Q Li, X Y Zhou
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Histone deacetylase 6 (HDAC6) is frequently altered in DLBCL and inhibition of HDAC6 has potent anti-tumor effects in vitro and in vivo. We profiled miRNAs that altered in the HDAC6 knockdown DLBCL cells with NanoString nCounter assay and identified microRNA-27b (miR-27b) as the most significantly increased miRNA. We validated decreased expression of miR-27b in DLBCL tissues, and we found that low expression of miR-27b was associated with poor overall survival of patients with DLBCL...
September 28, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29132323/integrative-microrna-and-mrna-deep-sequencing-expression-profiling-in-endemic-burkitt-lymphoma
#17
Cliff I Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A Otieno, John Michael Ong'echa, Ann M Moormann, Jeffrey A Bailey
BACKGROUND: Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29131834/plasma-microrna-profiling-exploring-better-biomarkers-for-lymphoma-surveillance
#18
Drirh Khare, Neta Goldschmidt, Aya Bardugo, Devorah Gur-Wahnon, Iddo Z Ben-Dov, Batia Avni
Early detection of relapsed lymphoma improves response and survival. Current tools lack power for detection of early relapse, while being cumbersome and expensive. We searched for sensitive biomarkers that precede clinical relapse, and serve for further studies on therapy response and relapse. We recruited 20 healthy adults, 14 diffuse large B-cell lymphoma (DLBCL) patients and 11 Hodgkin lymphoma (HL) patients at diagnosis. Using small-RNA sequencing we identified in DLBCL patients increased plasma levels of miR-124 and miR-532-5p, and decreased levels of miR-425, miR-141, miR-145, miR-197, miR-345, miR-424, miR-128 and miR-122...
2017: PloS One
https://www.readbyqxmd.com/read/29128636/identification-of-key-micrornas-associated-with-diffuse-large-b-cell-lymphoma-by-analyzing-serum-microrna-expressions
#19
Yuanyuan Meng, Lina Quan, Aichun Liu
PURPOSE: This study aimed to investigate the molecular mechanism underlying diffuse large B-cell lymphoma (DLBCL). METHODS: Serum miRNA expression analysis for the serum samples of patients with DLBCL and those of controls was performed using the Illumina sequencing technology. Differentially expressed miRNAs (DEMs) were identified on the basis of the sequencing data. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses and protein-protein interaction (PPI) network construction for the target genes of DEMs were also conducted...
November 8, 2017: Gene
https://www.readbyqxmd.com/read/29115608/microrna%C3%A2-27a-promotes-tumorigenesis-via-targeting-akt-in-triple-negative-breast-cancer
#20
Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Altered microRNA (miRNA/miR) expression regulates tumor development and progression in triple‑negative breast cancer (TNBC). The present study examined the effect of miR‑27a on proliferation, migration and invasion of TNBC cells in vitro and in vivo. An MTT assay was performed to examine the proliferation of MDA‑MB‑231 and MDA‑MB‑468 breast cancer cells with either overexpression of miR‑27a or downregulation of miR‑27a, in the presence or absence of radiation. The migratory and invasive abilities of MDA‑MB‑231 and MDA‑MB‑468 breast cancer cells were assessed by Transwell migration and Matrigel invasion assays...
October 26, 2017: Molecular Medicine Reports
keyword
keyword
33894
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"