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Lymphoma AND miRNA

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https://www.readbyqxmd.com/read/28534937/the-inhibitory-effect-of-meg3-mir-214-aifm2-axis-on-the-growth-of-t-cell-lymphoblastic-lymphoma
#1
Fang-Yi Fan, Rui Deng, Hai Yi, Hao-Ping Sun, Yan Zeng, Guang-Cui He, Yi Su
T-cell lymphoblastic lymphoma (T-LBL) is an aggressive malignancy with poor prognosis and high recurrence rate. Long non-coding RNA (lncRNA)-MEG3 is an important tumor suppressor in various cancers. The present study investigated the potential role of maternally expressed gene 3 (MEG3) in the progression of T-LBL. Suppressed expression of MEG3 was detected in T-LBL tissues compared with adjacent histologically normal tissues. Down-regulated level of MEG3 was also found in three T-LBL cell lines (CCRF-CEM, Jurkat and SUP-T1) compared with human T-cell line H9...
May 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28510513/putative-roles-as-oncogene-or-tumour-suppressor-of-the-mid-clustered-micrornas-in-gallid-alphaherpesvirus-2-gahv2-induced-marek-s-disease-lymphomagenesis
#2
Man Teng, Zu-Hua Yu, Pu Zhao, Guo-Qing Zhuang, Zi-Xiang Wu, Lu Dang, Hui-Zhen Li, Sheng-Ming Ma, Zhi-Zhong Cui, Gai-Ping Zhang, Run Wu, Jun Luo
In the last decade, numerous microRNAs (miRNAs) have been identified in diverse virus families, particularly in herpesviruses. Gallid alphaherpesvirus 2 (GaHV2) is a representative oncogenic alphaherpesvirus that induces rapid-onset T-cell lymphomas in its natural hosts, namely Marek's disease (MD). In the GaHV2 genome there are 26 mature miRNAs derived from 14 precursors assembled into three clusters, namely the Meq-cluster, Mid-cluster and LAT-cluster. Several GaHV2 miRNAs, especially those in the Meq-cluster (e...
May 15, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28503306/the-drive-to-generate-multiple-forms-of-oncogenic-cyclin-d1-transcripts-in-mantle-cell-lymphoma
#3
EDITORIAL
Chioniso Patience Masamha
Alternative polyadenylation is a rapidly emerging form of gene regulation, which in its simplest form, enables the generation of mRNA transcripts that code for the same protein but have 3'UTRs of different lengths and regulatory content. For oncogenes, shorter 3'UTRs would be preferred as a mechanism to evade miRNA regulation. The shortening of the 3'UTR of cyclin D1 in mantle cell lymphoma offers provocative insights into this process. Patient samples have revealed that 3'UTR shortening may occur due to mutations, or translocations that result in the generation of a chimeric 3'UTR...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28471196/-the-importance-of-microrna-deregulation-in-the-molecular-pathogenesis-and-histological-transformation-of-follicular-lymphoma
#4
K Musilová, J Deván, L Zlámalíková, L Křen, H Móciková, V Procházka, J Mayer, M Trněný, A Janíková, M Mráz
BACKGROUND: Molecular pathogenesis of follicular lymphoma (FL) is characterized by substantial dysregulation of epigenetic regulators. Many cases of FL are associated with the aberrant expression of non-coding regulatory RNAs, namely microRNAs (miRNA). Here we studied changes in miRNA expression and their association with histological transformation of FL to diffuse large B-cell lymphoma (DLBCL). MATERIAL AND METHODS: To identify changes in miRNA levels during FL transformation we performed a global expression analysis of 377 miRNAs in 16 samples (8 pairs) from FL patients vs...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28454513/mycbase-a-database-of-functional-sites-and-biochemical-properties-of-myc-in-both-normal-and-cancer-cells
#5
Debangana Chakravorty, Tanmoy Jana, Sukhen Das Mandal, Anuradha Seth, Anubrata Bhattacharya, Sudipto Saha
BACKGROUND: Myc is an essential gene having multiple functions such as in cell growth, differentiation, apoptosis, genomic stability, angiogenesis, and disease biology. A large number of researchers dedicated to Myc biology are generating a substantial amount of data in normal and cancer cells/tissues including Burkitt's lymphoma and ovarian cancer. RESULTS: MYCbase ( http://bicresources.jcbose.ac.in/ssaha4/mycbase ) is a collection of experimentally supported functional sites in Myc that can influence the biological cellular processes...
April 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28447761/mir-21-inhibitor-suppresses-cell-proliferation-and-colony-formation-through-regulating-the-pten-akt-pathway-and-improves-paclitaxel-sensitivity-in-cervical-cancer-cells
#6
Guohui Du, Dongmei Cao, Lingzheng Meng
The present study aimed to investigate the role and the molecular mechanisms underlying the effects of microRNA-21 (miR-21) on the proliferation, apoptosis and colony formation of cervical cancer cells, and to examine the role of miR-21 in mediating the sensitivity of cervical cancer cells to paclitaxel (PTX). Reverse transcription‑quantitative polymerase chain reaction was employed to determine the level of miR‑21 in various cervical cancer and normal cervical cells. The results revealed that the expression levels of miR-21 in cervical cancer cells were markedly higher when compared with normal cervical cells...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28445867/the-mir-106a-363xpcl1-mirna-cluster-induces-murine-t-cell-lymphoma-despite-transcriptional-activation-of-the-p27kip1-cell-cycle-inhibitor
#7
Daniel A Kuppers, Thomas M Schmitt, Harry C Hwang, Lavanya Samraj, Bruce E Clurman, Matthew L Fero
The miR-106a~363 cluster encodes 6 miRNAs on the X-chromosome which are abundant in blood cells and overexpressed in a variety of malignancies. The constituent miRNA of miR-106a~363 have functional activities in vitro that are predicted to be both oncogenic and tumor suppressive, yet little is known about their physiological functions in vivo. Mature miR-106a~363 (Mirc2) miRNAs are processed from an intragenic, non-protein encoding gene referred to as Xpcl1 (or Kis2), situated at an X-chromosomal locus frequently targeted by retroviruses in murine lymphomas...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28440396/downregulation-of-mir-10b-promotes-osteoblast-differentiation-through-targeting-bcl6
#8
Jizhou Yang, Shaojie Wang, Fengxian Wang, Xiaohong Mu, Yi Qu, Ziyi Zhao, Xing Yu
MicroRNAs (miRNAs or miRs) have been shown to play a critical role in osteoblast differentiation. miR-10b has been found to be downregulated during osteoblast differentiation; however, its precise effect on osteoblast differentiation remains unknown. In this study, we aimed to investigate the potential role of miR-10b and the potential underlying mechanism in regulating osteoblast differentiation. We found that miR-10b was downregulated during osteoblast differentiation. Overexpression of miR-10b inhibited osteoblast differentiation, whereas the suppression of miR-10b promoted osteoblast differentiation...
April 20, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28432871/mir-24-3p-is-overexpressed-in-hodgkin-lymphoma-and-protects-hodgkin-and-reed-sternberg-cells-from-apoptosis
#9
Ye Yuan, Joost Kluiver, Jasper Koerts, Debora de Jong, Bea Rutgers, F Reeny Abdul Razak, Martijn Terpstra, Boudewijn E Plaat, Ilja M Nolte, Arjan Diepstra, Lydia Visser, Klaas Kok, Anke van den Berg
miRNAs play important roles in biological processes, such as proliferation, metabolism, differentiation, and apoptosis, whereas altered expression levels contribute to diseases, such as cancers. We identified miRNAs with aberrant expression in Hodgkin lymphoma (HL) and investigated their role in pathogenesis. Small RNA sequencing revealed 84 significantly differentially expressed miRNAs in HL cell lines as compared to germinal center B cells. Three up-regulated miRNAs-miR-23a-3p, miR-24-3p, and miR-27a-3p-were derived from one primary miRNA transcript...
June 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28430743/microrna-148a-promotes-apoptosis-and-suppresses-growth-of-breast-cancer-cells-by-targeting-b-cell-lymphoma-2
#10
Qunying Li, Pingping Ren, Pengfei Shi, Yihan Chen, Feixiang Xiang, Li Zhang, Jing Wang, Qing Lv, Mingxing Xie
MicroRNAs (miRNAs) contribute toward tumorigenesis through the modulation of tumor-related genes. MiR-148a has been characterized as a tumor-suppressing miRNA and its downregulation has been reported in tumors of a variety of cancers. However, the functional role of miR-148a in breast cancer is not yet fully understood. Using both in-vitro and in-vivo models, we confirmed that miR-148a acts to inhibit the proliferation of breast cancer cells. Through the use of bioinformatic approaches in miRNA target prediction, we determined that B-cell lymphoma 2 (BCL-2) is a likely target of miR-148a...
July 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28400759/human-and-epstein-barr-virus-mirna-profiling-as-predictive-biomarkers-for-endemic-burkitt-lymphoma
#11
Cliff I Oduor, Mercedeh Movassagh, Yasin Kaymaz, Kiprotich Chelimo, Juliana Otieno, John M Ong'echa, Ann M Moormann, Jeffrey A Bailey
Endemic Burkitt lymphoma (eBL) is an aggressive B cell lymphoma and is associated with Epstein-Barr virus (EBV) and Plasmodium falciparum malaria co-infections. Central to BL oncogenesis is the over-expression of the MYC proto-oncogene which is caused by a translocation of an Ig enhancer in approximation to the myc gene. While whole genome/transcriptome sequencing methods have been used to define driver mutations and transcriptional dysregulation, microRNA (miRNA) dysregulation and differential expression has yet to be fully characterized...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28377796/redox-regulating-enzymes-and-connected-microrna-regulators-have-prognostic-value-in-classical-hodgkin-lymphomas
#12
Peeter Karihtala, Katja Porvari, Ylermi Soini, Kirsi-Maria Haapasaari
There are no previous studies assessing the microRNAs that regulate antioxidant enzymes in Hodgkin lymphomas (HLs). We determined the mRNA levels of redox regulating enzymes peroxiredoxins (PRDXs) I-III, manganese superoxide dismutase (MnSOD), nuclear factor erythroid-derived 2-like 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) from a carefully collected set of 41 classical HL patients before receiving any treatments. The levels of redoxmiRs, miRNAs known to regulate the above-mentioned enzymes, were also assessed, along with CD3, CD20, and CD30 protein expression...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28360912/exosomes-isolated-from-ascites-of-t-cell-lymphoma-bearing-mice-expressing-surface-cd24-and-hsp-90-induce-a-tumor-specific-immune-response
#13
Florencia Menay, Leticia Herschlik, Julieta De Toro, Federico Cocozza, Rodrigo Tsacalian, María José Gravisaco, María Paula Di Sciullo, Alejandrina Vendrell, Claudia I Waldner, Claudia Mongini
Extracellular vesicles (EVs), including endosome-derived nanovesicles (exosomes), are involved in cell-cell communication. Through transfer of their molecular contents, extracellular nanovesicles can alter the function of recipient cells. Due to these characteristics, EVs have shown potential as a new alternative for cancer immunotherapy. Tumor exosomes isolated from malignant ascites can activate dendritic cells, thereby priming the immune system to recognize and kill cancer cells. However, a suppressive role on tumor immune response has also been reported, suggesting that the neoplastic stage of carcinogenesis and the microenvironment where tumor cells grow may influence the amount of EVs released by the cell...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28345816/germline-variation-in-the-3-untranslated-region-of-the-pou2af1-gene-is-associated-with-susceptibility-to-lymphoma
#14
Kan Zhai, Jiang Chang, Jinlong Hu, Chen Wu, Dongxin Lin
Genetic variations in certain genes may alter the susceptibility to lymphoma. We searched electronic databases and selected candidate single-nucleotide polymorphisms (SNPs) located within 3'-untranslated regions (3'-UTRs) that might affect miRNA-binding ability in the 50 most dysregulated genes in lymphoma for further study. We found that rs1042752-located in the 3'-UTR of POU2AF1, which plays a vital role in lymphomagenesis-was significantly associated with lymphoma risk in a case-control study with 793 patients and 939 controls...
March 27, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28260044/microrna-125b-reverses-the-multidrug-resistance-of-nasopharyngeal-carcinoma-cells-via-targeting-of-bcl-2
#15
Tai-Ze Yuan, Huan-Huan Zhang, Xiao-Ling Lin, Jin-Xiu Yu, Qiu-Xiang Yang, Yin Liang, Jin Deng, Lai-Ji Huang, Xiu-Ping Zhang
Multidrug resistance (MDR) is a major clinical obstacle in the successful treatment of patients with metastatic nasopharyngeal carcinoma (NPC). Results from previous studies suggest that microRNAs (miRNA) may be involved in promoting MDR in multiple cancer types. However, the role of miR‑125b in modulating the MDR of NPC is elusive. In the present study, miR‑125b expression in cisplatin (DDP) ‑resistant CNE2 cells (CNE2/DDP) was compared with parental counterparts, using reverse transcription‑quantitative polymerase chain reaction...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259992/ebv%C3%A2-bart%C3%A2-6%C3%A2-3p-and-cellular-microrna%C3%A2-197-compromise-the-immune-defense-of-host-cells-in-ebv%C3%A2-positive-burkitt-lymphoma
#16
Yang-Min Zhang, Yan Yu, He-Ping Zhao
The present study aimed to identify the association between Epstein‑Barr virus (EBV) microRNA (miRNA) and cellular miRNA in compromising the immune system, which contributes to the development of Burkitt lymphoma (BL). The present study selected cellular miR‑197 as the focus of the experiments due to the previous report that it is differentially expressed and the observation that interleukin‑6 receptor (IL‑6R) is a virtual target of miR‑197 and EBV‑BamHI A region rightward transcript (BART)‑6‑3p...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259954/microrna-34c-is-regulated-by-p53-and-is-involved-in-sevoflurane-induced-apoptosis-in-the-developing-rat-brain-potentially-via-the-mitochondrial-pathway
#17
Xue Zhou, Dongfeng Xian, Jiehua Xia, Ying Tang, Wenda Li, Xiaohui Chen, Zhibin Zhou, Dihan Lu, Xia Feng
The commonly used inhalation anesthetic, sevoflurane, has been previously demonstrated to induce apoptosis in the developing brain; however, the underlying molecular mechanisms remain largely unknown. MicroRNAs (miRNAs) serve important roles in multiple physiological/pathological processes, such as cell death and survival. In the present study, the miRNA sequence that was most closely associated with sevoflurane‑induced apoptosis in the hippocampus of neonatal rat brains was identified. Seven‑day‑old Sprague Dawley rats were first exposed to 2...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259902/expression-of-mmu-mir-96-in-the-endometrium-during-early-pregnancy-and-its-regulatory-effects-on-stromal-cell-apoptosis-via-bcl2
#18
Yuan Yang, Yi Xie, Mengyun Wu, Yanqing Geng, Rong Li, Lei Xu, Xueqing Liu, Yongquan Pan
Decidualization of endometrial stromal cells is an important feature of implantation and pregnancy. The molecular mechanism underlying decidualization remains unclear, particularly regarding the microRNA (miRNA/miR) regulation of this process. The present study revealed the temporal and spatial distribution of mmu‑miR‑96 in the mouse uterus during early pregnancy by reverse transcription‑quantitative polymerase chain reaction and in situ hybridization. In addition, primary stromal cells were isolated from the mouse uterus and used to explore the role of mmu‑miR‑96 in decidualization...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28253538/the-identification-of-up-regulated-ebv-mir-bhrf1-2-5p-targeting-malt1-and-ebv-mir-bhrf1-3-in-the-circulation-of-patients-with-multiple-sclerosis
#19
Y F Wang, D D He, H W Liang, D Yang, H Yue, X M Zhang, R Wang, B Li, H X Yang, Y Liu, Y Chen, Y X Duan, C Y Zhang, X Chen, J Fu
Epstein-Barr virus (EBV) is a well-documented aetiological factor for multiple sclerosis (MS). EBV encodes at least 44 microRNAs (miRNAs) that are readily detectable in the circulation of human. Previous studies have demonstrated that EBV-encoded miRNAs regulate host immune response and may serve as biomarkers for EBV-associated diseases. However, the roles of EBV miRNAs in MS are still unknown. To fill the gap, we conducted a comprehensive profiling of 44 mature EBV miRNAs in 30 relapsing-remitting MS (RRMS) patients at relapse and 30 matched healthy controls...
March 2, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28251496/brg1-regulation-by-mir-155-in-human-leukemia-and-lymphoma-cell-lines
#20
M Cuadros, V Sánchez-Martín, A Herrera, C Baliñas, J Martín-Padrón, L Boyero, P Peinado, P P Medina
INTRODUCTION/PURPOSE: BRG1 is a key regulator of leukemia stem cells. Indeed, it has been observed that this type of cells is unable to divide, survive and develop new tumors when BRG1 is down-regulated. MATERIALS AND METHODS: We assessed BRG1 and miR-155 expression in 23 leukemia cell lines, and two no pathological lymphocyte samples using qPCR. MiR-155 transfection and western blot were used to analyze the relationship between miR-155 and its validated target, BRG1, by measuring protein expression levels...
March 1, 2017: Clinical & Translational Oncology
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