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https://www.readbyqxmd.com/read/28239579/neck-trauma-ent-prospects
#1
Kavita Sachdeva, Aparaajita Upadhyay
Neck trauma is a very important surgical emergency faced by ENT surgeons in day to day practice. They are potentially life threatening conditions due to the presence of many vital structures in this area. Timely presentation to the referral centre and proper multidisciplinary approach towards management plays a pivotal role in the healing pattern of the wound and prevention of serious complication like shock, sepsis, laryngeal stenosis or fistula formation. A retrospective study was done in ENT Department, NSCB Medical College, Jabalpur, Madhya Pradesh, India during the period of 2014-2016...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28239466/nivolumab-induced-myxedema-crisis
#2
Uqba Khan, Humaira Rizvi, Dahlia Sano, Jane Chiu, Tarik Hadid
BACKGROUND: Nivolumab is an anti-programmed cell death (anti-PD-1) monoclonal antibody that is approved by Food and Drug Administration for treatment of metastatic non-small cell lung cancer, metastatic melanoma, relapsed Hodgkin lymphoma and advanced renal cell cancer. We report a rare case of myxedema crisis induced by nivolumab in a patient with metastatic squamous cell carcinoma of lung. CASE PRESENTATION: Fifty three-year old woman with metastatic squamous cell carcinoma currently on treatment with nivolumab presented with diffuse facial and tongue swelling, slurred speech, depressed mentation, fatigue and weakness...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28238469/role-of-laminin-332-in-lymph-node-metastasis-of-papillary-thyroid-carcinoma
#3
Kyoung Ho Oh, June Choi, Jeong-Soo Woo, Seung Kuk Baek, Kwang Yoon Jung, Min Ji Koh, Young-Sik Kim, Soon Young Kwon
OBJECTIVE: The invasiveness of papillary thyroid carcinoma (PTC), including the occurrence of cervical lymph node metastasis, is the main determining factors contributing to recurrence and poor prognosis. Laminin 332 is a glycoprotein involved in cell migration and cancer cell invasion into surrounding tissues and is therefore related to poor prognosis in many cancers. Here, we investigated the expression and role of laminin 332 in PTC and examine the possibility that laminin 332 could be involved in the invasiveness of PTC...
February 23, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28238453/vitiligo-and-overt-thyroid-diseases-a-nationwide-population-based-study-in-korea
#4
Jung Min Bae, June Hyunkyung Lee, Jae Seung Yun, Byeol Han, Tae Young Han
BACKGROUND: Associations between vitiligo and thyroid diseases have been reported repeatedly. OBJECTIVE: We investigated the associations between vitiligo and overt autoimmune thyroid diseases and thyroid cancer using the Korean National Health Insurance claims database. METHODS: We defined patients with vitiligo as those whose records showed ≥4 physician contacts between 2009 and 2013 in which vitiligo was the principal diagnosis. We also established an age- and sex-matched control group without vitiligo (2 per 1 vitiligo patient)...
February 23, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28238262/a-cell-free-protein-synthesis-approach-to-biosensing-htrb-specific-endocrine-disruptors
#5
Amin S M Salehi, Miriam J Shakalli Tang, Mark Thomas Smith, Jeremy M Hunt, Robert A Law, David W Wood, Bradley Charles Bundy
Here we introduce a Rapid Adaptable Portable In-vitro Detection biosensor platform (RAPID) for detecting ligands that interact with NHRs. The RAPID platform can be adapted for field use, allowing rapid evaluation of EDC presence or absence in environmental samples, and could also be applied for drug screening. The biosensor is based on an engineered, allosterically-activated fusion protein, which contains the ligand-binding domain (LBD) from a target NHR (human thyroid receptor in this work). In vitro expression of this protein using cell-free protein synthesis (CFPS) technology in the presence of an EDC leads to activation of a reporter enzyme, reported through a straightforward colorimetric assay output...
February 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28238161/effect-of-energy-based-devices-on-voice-quality-after-total-thyroidectomy
#6
Server Sezgin Uludag, Serkan Teksoz, Akif Enes Arikan, Ozge Tarhan, Haydar Murat Yener, Murat Ozcan, Whitney Liddy, Gregory William Randolph
Voice alteration is an important complication of thyroid surgery and is closely related to patients' quality of life. There are no studies analyzing effect of energy-based devices (EBD) on voice quality (VQ). Aim of this prospective study is to evaluate impact of sutureless total thyroidectomy performed with EBDs on objective voice parameters of patients without recurrent laryngeal nerve (RLN) and/or external branch of superior laryngeal nerve (EBSLN) injury. Sixty patients underwent total thyroidectomy with meticulous dissection of EBSLN...
February 25, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28237867/exploratory-analysis-of-biomarkers-associated-with-clinical-outcomes-from-the-study-of-lenvatinib-in-differentiated-cancer-of-the-thyroid
#7
Makoto Tahara, Martin Schlumberger, Rossella Elisei, Mouhammed Amir Habra, Naomi Kiyota, Ralf Paschke, Corina E Dutcus, Taro Hihara, Shannon McGrath, Mark Matijevic, Tadashi Kadowaki, Yasuhiro Funahashi, Steven I Sherman
BACKGROUND: Lenvatinib significantly prolonged progression-free survival (PFS) versus placebo in the phase III Study of (E7080) LEnvatinib in differentiated Cancer of the Thyroid (SELECT) of patients with radioiodine-refractory differentiated thyroid cancer. This exploratory analysis investigated potential predictive biomarkers of lenvatinib efficacy and target engagement. PATIENTS AND METHODS: Circulating cytokine/angiogenic factors (CAFs) in blood samples collected at baseline and throughout treatment were analysed from patients randomised to receive lenvatinib or placebo from August 5, 2011 to October 4, 2012...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28237669/disruption-of-the-hypothalamic-pituitary-thyroid-axis-on-co-exposures-to-dithiocarbamate-and-neonicotinoid-pesticides-study-in-a-wildlife-bird-amandava-amandava
#8
Surya Prakash Pandey, Banalata Mohanty
Non-target organisms, including human and wildlife, are susceptible to deleterious effects of pesticide mixtures in their environment. Present study demonstrated the disruption of the hypothalamic-pituitary-thyroid (HPT) axis in a seasonally breeding wildlife bird Amandava amandava on co-exposure to dithiocarbamate mancozeb/MCZ and neonicotinoid imidacloprid/IMI, at concentrations even lower than respective environmentally realistic exposure level of each of the pesticide. Adult male birds (n=8/group) were exposed individually to 0...
February 22, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28237646/recurrence-associated-genes-in-papillary-thyroid-cancer-an-analysis-of-data-from-the-cancer-genome-atlas
#9
Ming-Nan Chien, Po-Sheng Yang, Jie-Jen Lee, Tao-Yeuan Wang, Yi-Chiung Hsu, Shih-Ping Cheng
BACKGROUND: Recurrence of papillary thyroid cancer is not uncommon, but incorporating clinicopathologic parameters to predict recurrence is suboptimal. The aim of this study was to identify systemically recurrence-associated genes using The Cancer Genome Atlas RNA sequencing database. METHODS: A total of 504 patients with transcriptome sequencing data of the primary neoplasm were included in this study. High and low levels of expression of each gene were defined by median splits...
February 22, 2017: Surgery
https://www.readbyqxmd.com/read/28237641/sternal-metastasis-as-first-presentation-of-a-well-differentiated-papillary-thyroid-carcinoma
#10
Eleftherios Spartalis, Demetrios Moris, Periklis Tomos
No abstract text is available yet for this article.
February 22, 2017: Surgery
https://www.readbyqxmd.com/read/28237243/non-small-cell-lung-cancer-patients-with-adenocarcinoma-morphology-have-a-better-outcome-compared-with-patients-diagnosed-with-non-small-cell-lung-cancer-favor-adenocarcinoma
#11
Iris Shiran, Eyal Heller, Shlomit Jessel, Iris Kamer, Inbal Daniel-Meshulam, Rossie Navon, Damien Urban, Amir Onn, Jair Bar
BACKGROUND: Non-small-cell lung cancer (NSCLC) includes 2 major histologic subtypes: squamous cell carcinoma and non-squamous carcinoma, mainly adenocarcinoma, a distinction that carries significant clinical and therapeutic implications. NSCLC is diagnosed as adenocarcinoma or as squamous cell carcinoma on the basis of histologic parameters. However, when morphology is inconclusive, tumors with immunohistochemistry (IHC) findings characteristic of adenocarcinoma are referred to as "NSCLC favor adenocarcinoma" (NFA)...
February 2, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28237002/congenital-hypothyroidism-role-of-nuclear-medicine
#12
REVIEW
Isabelle Keller-Petrot, Juliane Leger, Aline Sergent-Alaoui, Claire de Labriolle-Vaylet
Thyroid scintigraphy holds a key place in the etiologic workup of neonatal hypothyroidism. Routine screening for this disorder in maternity hospitals in industrialized countries, for nearly 40 years, has permitted early treatment and thereby helped to prevent its physical and mental complications. Neonatal hypothyroidism affects approximately 1 in 3000 births. The most common causes are abnormal thyroid gland development and defective hormone synthesis by an eutopic thyroid gland. The incidence of the latter has risen in recent years, for reasons that remain unclear...
March 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28237001/radioiodine-therapy
#13
REVIEW
Markus Luster, Andreas Pfestroff, Heribert Hänscheid, Frederik A Verburg
Radioiodine therapy for benign and malignant thyroid disease rose at the birth of nuclear medicine. Since then, this procedure has been performed countless of times in adult and in pediatric patients alike, and has contributed to a normalization of life expectancy in all but I-131 refractory differentiated thyroid cancer (DTC) cases. As (131)I therapy in children is almost exclusively given for DTC, this review of radioiodine therapy in children focuses on patients with malignant thyroid disease. The aim of the present review is to provide an overview of the indications, practical execution, and controversies surrounding (131)I therapy for malignant tumors in pediatric patients...
March 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28236731/immunohistochemical-methods-as-an-aid-in-estimating-the-time-since-death
#14
Jan Ortmann, Elke Doberentz, Burkhard Madea
For the estimation of time since death in the early postmortem interval, a large repertoire of valid methods is available. With increasing time since death the estimation of the postmortem interval becomes more imprecise and unreliable because validated methods are missing. Wehner et al. developed a method to estimate the time since death using immunohistochemical staining. Proteins undergo degradation after death and this reduces their stainability. Previous studies have explored the development of a method to estimate the time since death using immunohistochemical staining...
February 14, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28236659/a-simple-formulation-for-deriving-effective-atomic-numbers-via-electron-density-calibration-from-dual-energy-ct-data-in-the-human-body
#15
Masatoshi Saito, Shota Sagara
PURPOSE: The main objective of this study is to propose a simple formulation (which we called DEEDZ) for deriving effective atomic numbers (Zeff ) via electron density (ρe ) calibration from dual-energy (DE) CT data. We carried out numerical analysis of this DEEDZ method for a large variety of materials with known elemental compositions and mass densities using an available photon cross sections database. The new conversion approach was also applied to previously published experimental DECT data to validate its practical feasibility...
February 25, 2017: Medical Physics
https://www.readbyqxmd.com/read/28236537/efficiency-of-intraoperative-neuromonitoring-on-voice-outcomes-after-thyroid-surgery
#16
Seung-Kuk Baek, Kijeong Lee, Dongju Oh, Sung Hoon Kang, Soon-Young Kwon, Jeong-Soo Woo, Jae-Gu Cho, Kyung Ho Oh, Doh Young Lee, Kwang-Yoon Jung
OBJECTIVE: Voice disturbance is an important problem after thyroidectomy. The aim of this study was to evaluate the efficiency of intraoperative neuromonitoring (IONM) in reducing early phonation change by comparing postoperative voice outcomes. METHODS: The study retrospectively enrolled 68 consecutive female patients who had undergone IONM thyroidectomy for papillary thyroid carcinoma occurring between January 2014 and November 2014. A historical group of 117 similar female patients not receiving IONM thyroidectomy was used as an external control...
February 21, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28236116/clinical-pharmacokinetic-and-pharmacodynamic-profile-of-lenvatinib-an-orally-active-small-molecule-multitargeted-tyrosine-kinase-inhibitor
#17
Ziad Hussein, Hitoshi Mizuo, Seiichi Hayato, Masayuki Namiki, Robert Shumaker
Lenvatinib is a multikinase inhibitor that targets vascular endothelial growth factor (VEGF) receptors 1-3, fibroblast growth factor receptors 1-4, platelet-derived growth factor receptor-alpha, and RET and KIT proto-oncogenes. Lenvatinib is approved for the treatment of radioiodine-refractory differentiated thyroid cancer in the United States (US), European Union (EU), Canada, Japan, and Switzerland. It is also approved in combination with everolimus for the treatment of advanced renal cell carcinoma following ≥1 VEGF-targeted treatment in the US and EU...
February 24, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28236059/ewsr1-rearrangement-is-a-frequent-event-in-papillary-thyroid-carcinoma-and-in-carcinoma-of-the-thyroid-with-ewing-family-tumor-elements-cefte
#18
G Oliveira, A Polónia, J M Cameselle-Teijeiro, D Leitão, S Sapia, M Sobrinho-Simões, C Eloy
Carcinomas of the thyroid with Ewing family tumor element (CEFTEs) are small-cell thyroid tumors with epithelial differentiation that disclose p63 expression and EWSR1-FLI1 rearrangement, carry a favorable prognosis and may co-exist with papillary thyroid carcinoma (PTC) foci. Two histogenetic hypotheses have been advanced regarding the origin of CEFTEs: arising in PTCs or in solid cell nests (SCN). A total of 3 CEFTEs, 54 PTCs, and 10 SCNs were reviewed, and fluorescence in situ hybridization (FISH) technique was performed in all cases to search for the presence of EWSR1 rearrangements...
February 24, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28235956/genomic-complexity-and-targeted-genes-in-anaplastic-thyroid-cancer-cell-lines
#19
Eleanor Louise Woodward, Andrea Biloglav, Naveen Ravi, Minjun Yang, Lars Ekblad, Johan Wennerberg, Kajsa Paulsson
Anaplastic thyroid cancer (ATC) is a highly malignant disease with very short median survival times. Few studies have addressed the underlying somatic mutations, and the genomic landscape of ATC thus remains largely unknown. In the present study, we have ascertained copy number aberrations, gene fusions, gene expression patterns, and mutations in early-passage cells from ten newly established ATC cell lines using single nucleotide polymorphism (SNP) array analysis, RNA-sequencing and whole exome sequencing...
February 24, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28235882/fda-approval-summary-accelerated-approval-of-pembrolizumab-for-second-line-treatment-of-metastatic-melanoma
#20
Meredith K Chuk, Jennie T Chang, Marc R Theoret, Emmanuel Sampene, Kun He, Shawna L Weis, Whitney S Helms, Runyan Jin, Hongshan Li, Jingyu Yu, Hong Zhao, Liang Zhao, Mark Paciga, Deborah Schmiel, Rashmi Rawat, Patricia Keegan, Richard Pazdur
On September 4, 2014, FDA approved pembrolizumab (KEYTRUDA, Merck Sharp & Dohme Corp.) with a recommended dose of 2 mg/kg every 3 weeks by intravenous infusion for the treatment of patients with unresectable or metastatic melanoma who have progressed following ipilimumab and, if BRAF V600 mutation positive, a BRAF inhibitor. Approval was based on demonstration of objective tumor responses with prolonged response durations in 89 patients enrolled in a randomized, multicenter, open-label, dose-finding, and activity-estimating Phase 1 trial...
February 24, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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