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https://www.readbyqxmd.com/read/28423800/project-peach-at-uclh-student-projects-in-healthcare-computing
#1
Navin Ramachandran, Dean Mohamedally, Paul Taylor
A collaboration between clinicians at UCLH and the Dept of Computer Science at UCL is giving students of computer science the opportunity to undertake real healthcare computing projects as part of their education. This is enabling the creation of a significant research computing platform within the Trust, based on open source components and hosted in the cloud, while providing a large group of students with experience of the specific challenges of health IT.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28421671/controlled-growth-of-ch3nh3pbi3-using-a-dynamically-dispensed-spin-coating-method-improving-efficiency-with-a-reproducible-pbi2-blocking-layer
#2
Yingzhuang Ma, Parth Vashishtha, Kai Chen, Elijah Peach, David Ohayon, Justin Hodgkiss, Jonathan Halpert
It is commonly believed that excess PbI2 has beneficial effects for perovskite solar cells due to the modification of charge transport behavior at interfaces, by surface passivation and by blocking electron-hole recombination. Here, we introduce a dynamically dispensed spin coating technique in a two-step deposition to form a perovskite layer with controllable quantities of crystalline PbI2. Using this technique, the concentration of CH3NH3I solution is kept constant at the reaction interface, ensuring smooth growth of films...
April 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28401436/cypress-pollinosis-from-tree-to-clinic
#3
REVIEW
Denis Charpin, Christian Pichot, Jordina Belmonte, Jean-Pierre Sutra, Jarmila Zidkova, Pascal Chanez, Youcef Shahali, Hélène Sénéchal, Pascal Poncet
Cypress (Cupressus sp.pl) is a genus within the Cupressaceae family. This family covers all of the Earth's continents except for Antarctica, and it includes about 160 species. The most important taxa for allergic diseases belong to five different genera: Cupressus, Hesperocyparis, Juniperus, Cryptomeria, and Chamaecyparis. Cupressaceae species share a common pollen type that can even include the genus Taxus (Taxaceae) when this plant is also present. As Juniperus oxycedrus pollinates in October, Cupressus sempervirens in January and February, Hesperocyparis arizonica (prev...
April 11, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28401146/effects-of-bunch-rot-botrytis-cinerea-and-powdery-mildew-erysiphe-necator-fungal-diseases-on-wine-aroma
#4
Angela Lopez Pinar, Doris Rauhut, Ernst Ruehl, Andrea Buettner
This study aimed to characterize the effects of bunch rot and powdery mildew on the primary quality parameter of wine, the aroma. The influence of these fungal diseases was studied by comparative Aroma Extract Dilution Analyses (AEDA) and sensory tests. The effect of bunch rot was investigated on three grape varieties, namely White Riesling, Red Riesling and Gewürztraminer and that of powdery mildew on the hybrid Gm 8622-3; thereby, samples were selected that showed pronounced cases of infection to elaborate potential currently unknown effects...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28398597/results-from-the-first-in-human-study-with-ozanimod-a-novel-selective-sphingosine-1-phosphate-receptor-modulator
#5
Jonathan Q Tran, Jeffrey P Hartung, Robert J Peach, Marcus F Boehm, Hugh Rosen, Heather Smith, Jennifer L Brooks, Gregg A Timony, Allan D Olson, Sheila Gujrathi, Paul A Frohna
The sphingosine-1-phosphate 1 receptor (S1P1R ) is expressed by lymphocytes, dendritic cells, and vascular endothelial cells and plays a role in the regulation of chronic inflammation and lymphocyte egress from peripheral lymphoid organs. Ozanimod is an oral selective modulator of S1P1R and S1P5R receptors in clinical development for the treatment of chronic immune-mediated, inflammatory diseases. This first-in-human study characterized the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of ozanimod in 88 healthy volunteers using a range of single and multiple doses (7 and 28 days) and a dose-escalation regimen...
April 11, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28396315/peaches-and-cream-in-a-multi-ethnic-society
#6
Pip Fisher
No abstract text is available yet for this article.
April 10, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28392275/exploring-the-influence-of-indololactone-structure-on-selectivity-for-binding-to-the-c1-domains-of-pkc%C3%AE-pkc%C3%AE%C2%B5-and-rasgrp
#7
Eleonora Elhalem, Lucía Gandolfi Donadío, Xiaoling Zhou, Nancy E Lewin, Lia C Garcia, Christopher C Lai, James A Kelley, Megan L Peach, Peter M Blumberg, María J Comin
C1 domain-containing proteins, such as protein kinase C (PKC), have a central role in cellular signal transduction. Their involvement in many diseases, including cancer, cardiovascular disease, and immunological and neurological disorders has been extensively demonstrated and has prompted a search for small molecules to modulate their activity. By employing a diacylglycerol (DAG)-lactone template, we have been able to develop ultra potent analogs of diacylglycerol with nanomolar binding affinities approaching those of complex natural products such as phorbol esters and bryostatins...
March 10, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28392095/real-time-analysis-of-the-binding-of-fluorescent-vegf165a-to-vegfr2-in-living-cells-effect-of-receptor-tyrosine-kinase-inhibitors-and-fate-of-internalized-agonist-receptor-complexes
#8
Laura E Kilpatrick, Rachel Friedman-Ohana, Diana C Alcobia, Kristin Riching, Chloe J Peach, Amanda J Wheal, Stephen J Briddon, Matthew B Robers, Kris Zimmerman, Thomas Machleidt, Keith V Wood, Jeanette Woolard, Stephen J Hill
Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. Here we have used a novel stoichiometric protein-labeling method to generate a fluorescent variant of VEGF (VEGF165a-TMR) labeled on a single cysteine within each protomer of the antiparallel VEGF homodimer. VEGF165a-TMR has then been used in conjunction with full length VEGFR2, tagged with the bioluminescent protein NanoLuc, to undertake a real time quantitative evaluation of VEGFR2 binding characteristics in living cells using bioluminescence energy transfer (BRET)...
April 6, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28382283/protective-effect-of-white-fleshed-peach-prunus-persica-l-batsch-on-chronic-nicotine-induced-toxicity
#9
Hyun-Jeong Kim, Kwang-Kyun Park, Won-Yoon Chung, Sun Kyoung Lee, Ki-Rim Kim
BACKGROUND: Nicotine is a major toxic component of tobacco smoke and has been recognized as a risk factor to induce oxidative tissue damage, which is a precursor to cardiovascular diseases, lung-related diseases, and cancers. Peaches (Prunus persica) have been used for the treatment of degenerative disorders, such as hypermenorrhea, dysmenorrhea, and infertility in Asian countries. In this study, we investigated the effects of white-fleshed peach on the excretion of nicotine metabolites and 1-hydroxypyrene in smokers and chronic nicotine-induced tissue damages in mice...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28382047/genome-wide-identification-expression-patterns-and-functional-analysis-of-udp-glycosyltransferase-family-in-peach-prunus-persica-l-batsch
#10
Boping Wu, Liuxiao Gao, Jie Gao, Yaying Xu, Hongru Liu, Xiangmei Cao, Bo Zhang, Kunsong Chen
Peach (Prunus persica L. Batsch) is a commercial grown fruit trees, important because of its essential nutrients and flavor promoting secondary metabolites. The glycosylation processes mediated by UDP-glycosyltransferases (UGTs) play an important role in regulating secondary metabolites availability. Identification and characterization of peach UGTs is therefore a research priority. A total of 168 peach UGT genes that distributed unevenly across chromosomes were identified based on their conserved PSPG motifs...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28369135/engineered-stem-cell-niche-matrices-for-rotator-cuff-tendon-regenerative-engineering
#11
M Sean Peach, Daisy M Ramos, Roshan James, Nicole L Morozowich, Augustus D Mazzocca, Steven B Doty, Harry R Allcock, Sangamesh G Kumbar, Cato T Laurencin
Rotator cuff (RC) tears represent a large proportion of musculoskeletal injuries attended to at the clinic and thereby make RC repair surgeries one of the most widely performed musculoskeletal procedures. Despite the high incidence rate of RC tears, operative treatments have provided minimal functional gains and suffer from high re-tear rates. The hypocellular nature of tendon tissue poses a limited capacity for regeneration. In recent years, great strides have been made in the area of tendonogenesis and differentiation towards tendon cells due to a greater understanding of the tendon stem cell niche, development of advanced materials, improved scaffold fabrication techniques, and delineation of the phenotype development process...
2017: PloS One
https://www.readbyqxmd.com/read/28362797/characterizing-the-spatial-distribution-of-brown-marmorated-stink-bug-halyomorpha-halys-st%C3%A3-l-hemiptera-pentatomidae-populations-in-peach-orchards
#12
Noel G Hahn, Cesar Rodriguez-Saona, George C Hamilton
Geospatial analyses were used to investigate the spatial distribution of populations of Halyomorpha halys, an important invasive agricultural pest in mid-Atlantic peach orchards. This spatial analysis will improve efficiency by allowing growers and farm managers to predict insect arrangement and target management strategies. Data on the presence of H. halys were collected from five peach orchards at four farms in New Jersey from 2012-2014 located in different land-use contexts. A point pattern analysis, using Ripley's K function, was used to describe clustering of H...
2017: PloS One
https://www.readbyqxmd.com/read/28360872/integrative-priming-of-compositional-and-locative-relations
#13
Lara L Jones, Lee H Wurm, Ryan D Calcaterra, Noa Ofen
Integrative priming refers to the facilitated recognition of a target word (bench) as a real word following a prime (park). Prior integrative priming studies have used a wide variety of integrative relations including temporal (summer rain), topical (travel book), locative (forest river), and compositional (peach pie) relations. Yet differences in the types of integrative relations may yield differences in the underlying explanatory processes of integrative priming. In this study, we compared the magnitude, time course, and three theoretically based correlates of integrative priming for compositional (stone table) and locative (patio table) pairs in a lexical decision task across four stimulus onset asynchronies (SOAs; 50, 300, 800, and 1,600 ms)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28351057/genome-wide-identification-and-analysis-of-the-type-b-authentic-response-regulator-gene-family-in-peach-prunus-persica
#14
Jingjue Zeng, Xudong Zhu, Muhammad S Haider, Xicheng Wang, Cheng Zhang, Chen Wang
The type-B authentic response regulator (ARR-B) family members serve as DNA-binding transcriptional regulators, whose activities are probably regulated by phosphorylation/dephosphorylation, resulting in the rapid induction of type-A ARR genes. Type-B ARRs are believed to be involved in many biological processes, including cytokinin signaling, plant growth, and stress responses through a chaperone or by isomerization of proline residues during protein folding. The public availability of complete peach genome sequences allows the identification of 23 ARR-B genes by HMMER and blast analysis...
2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28346234/outstanding-animal-studies-in-allergy-i-from-asthma-to-food-allergy-and-anaphylaxis
#15
Erika Jensen-Jarolim, Isabella Pali-Schöll, Franziska Roth-Walter
PURPOSE OF REVIEW: Animal models published within the past 18 months on asthma, food allergy and anaphylaxis, all conditions of rising public health concern, were reviewed. RECENT FINDINGS: While domestic animals spontaneously develop asthma, food allergy and anaphylaxis, in animal models, divergent sensitization and challenge routes, dosages, intervals and antigens are used to induce asthmatic, food allergic or anaphylactic phenotypes. This must be considered in the interpretation of results...
March 24, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28345939/macrophilone-a-structure-elucidation-total-synthesis-and-functional-evaluation-of-a-biologically-active-iminoquinone-from-the-marine-hydroid-macrorhynchia-philippina
#16
Katherine Zlotkowski, William M Hewitt, Pengcheng Yan, Heidi R Bokesch, Megan L Peach, Marc C Nicklaus, Barry R O'Keefe, James B McMahon, Kirk R Gustafson, John S Schneekloth
A previously uncharacterized pyrroloiminoquinone natural product, macrophilone A, was isolated from the stinging hydroid Macrorhynchia philippina. The structure was assigned utilizing long-range NMR couplings and DFT calculations and proved by a concise, five-step total synthesis. Macrophilone A and a synthetic analogue displayed potent biological activity, including increased intracellular reactive oxygen species levels and submicromolar cytotoxicity toward lung adenocarcinoma cells.
April 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28337785/transcriptomic-and-metabolic-analyses-provide-new-insights-into-chilling-injury-in-peach-fruit
#17
Ke Wang, Xue-Ren Yin, Bo Zhang, Don Grierson, Chang-Jie Xu, Kun-Song Chen
Low temperature conditioning (LTC) alleviates peach fruit chilling injury but the underlying molecular basis is poorly understood. Here, changes in transcriptome, ethylene production, flesh softening, internal browning, and membrane lipids were compared in fruit maintained in constant 0 °C and LTC (pre-storage at 8 °C for 5 days before storage at 0 °C). LTC resulted in a higher rate of ethylene production and a more rapid flesh softening as a result of higher expression of ethylene biosynthetic genes and a series of cell wall hydrolases...
March 24, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28336950/dual-regulation-of-water-retention-and-cell-growth-by-a-stress-associated-protein-sap-gene-in-prunus
#18
Alba Lloret, Ana Conejero, Carmen Leida, César Petri, Francisco Gil-Muñoz, Lorenzo Burgos, María Luisa Badenes, Gabino Ríos
We have identified a gene (PpSAP1) of Prunus persica coding for a stress-associated protein (SAP) containing Zn-finger domains A20 and AN1. SAPs have been described as regulators of the abiotic stress response in plant species, emerging as potential candidates for improvement of stress tolerance in plants. PpSAP1 was highly expressed in leaves and dormant buds, being down-regulated before bud dormancy release. PpSAP1 expression was moderately induced by water stresses and heat in buds. In addition, it was found that PpSAP1 strongly interacts with polyubiquitin proteins in the yeast two-hybrid system...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330195/identification-and-characterization-of-endophytic-bacteria-isolated-from-in-vitro-cultures-of-peach-and-pear-rootstocks
#19
Fakhra Liaqat, Rengin Eltem
Endophytes are microorganisms which live symbiotically with almost all varieties of plant and in turn helping the plant in a number of ways. Instead of satisfactory surface sterilization approaches, repeatedly occurring bacterial growth on in vitro rootstock cultures of peach and pear was identified and isolated as endophytic bacteria in our present study. Five different isolates from peach rootstocks were molecularly identified by 16S rRNA gene sequencing as Brevundimonas diminuta, Leifsonia shinshuensis, Sphingomonas parapaucimobilis Brevundimonas vesicularis, Agrobacterium tumefaciens while two endophytic isolates of pear were identified as Pseudoxanthomonas mexicana, and Stenotrophomonas rhizophilia...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330149/myb-transcription-factor-isolated-from-raphanus-sativus-enhances-anthocyanin-accumulation-in-chrysanthemum-cultivars
#20
Eun Sun Kee, Aung Htay Naing, Sun Hyung Lim, Jeung Sul Han, Chang Kil Kim
A MYB transcription factor gene, RsMYB1, from radish was introduced into the chrysanthemum cultivars 'Peach ND', 'Peach Red', and 'Vivid Scarlet' under the control of the cauliflower mosaic virus 35S promoter. Presence of RsMYB1 in transgenic lines was confirmed using polymerase chain reaction (PCR). Results of reverse-transcription-PCR analysis revealed that the expression of RsMYB1 was stable in all transgenic lines and could enhance the expression levels of three key biosynthetic genes (F3H, DFR, and ANS) involved in anthocyanin production...
June 2016: 3 Biotech
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