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JOURNAL ARTICLE
Yubo Zhang, Ruiye Yang, Chunyu Xu, Yanqin Zhang, Mengqi Deng, Di Wu, Fan Tang, Xinyu Liu, Yiding Han, Yang Zhan, Jinwei Miao
BACKGROUND: Lymphocyte activation gene-3 (LAG-3) is a novel molecule that participates in the immune escape of tumor cells and is a target for immunotherapy. However, the expression of LAG-3 in patients with endometrial cancer (EC) has not been comprehensively characterized. OBJECTIVES: We elucidated the expression of LAG-3 and investigated its correlation with clinicopathological parameters, ProMisE subtypes, CD8+ T-cell infiltration and relapse-free survival (RFS) in a retrospective cohort of 421 patients with endometrial cancer...
August 2022: Pathology, Research and Practice
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JOURNAL ARTICLE
Laure Perchepied, Thomas Kroj, Maurice Tronchet, Olivier Loudet, Dominique Roby
BACKGROUND: Low-level, partial resistance is pre-eminent in natural populations, however, the mechanisms underlying this form of resistance are still poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we used the model pathosystem Pseudomonas syringae pv. tomato DC3000 (Pst) - Arabidopsis thaliana to study the genetic basis of this form of resistance. Phenotypic analysis of a set of Arabidopsis accessions, based on evaluation of in planta pathogen growth revealed extensive quantitative variation for partial resistance to Pst...
2006: PloS One
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