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https://www.readbyqxmd.com/read/27920416/re-evaluating-the-inhibition-of-stress-erosions-revise-a-protocol-for-pilot-randomized-controlled-trial
#1
Waleed Alhazzani, Gordon Guyatt, John C Marshall, Richard Hall, John Muscedere, Francois Lauzier, Lehana Thabane, Mohammed Alshahrani, Shane W English, Yaseen M Arabi, Adam M Deane, Tim Karachi, Bram Rochwerg, Simon Finfer, Nick Daneman, Nicole Zytaruk, Diane Heel-Ansdell, Deborah Cook, On Behalf Of
INTRODUCTION: Clinicians routinely administer stress ulcer prophylaxis to mechanically ventilated patients in the intensive care unit (ICU), most commonly prescribing proton pump inhibitors (PPIs). However, the incidence of gastrointestinal (GI) bleeding from stress ulceration is low and recent observational studies suggest these agents may increase infections. Therefore, a large randomized clinical trial (RCT) is needed to inform modern practice. The aim of this multicenter pilot trial is to determine the feasibility of performing a large RCT to investigate the efficacy and safety of withholding intravenous pantoprazole...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27913539/prevention-of-central-nervous-system-sequelae-in-sickle-cell-disease-without-evidence-from-randomized-controlled-trials-the-case-for-a-team-based-learning-collaborative
#2
Michael R DeBaun, Allison A King
Since 1998, the National Institutes of Health has funded 5 randomized controlled trials (RCTs) for primary and secondary prevention of strokes in children with sickle cell anemia (SCA). In a systematic fashion, these trials have significantly advanced the care of children with SCA. In the absence of an RCT, clinicians are often compelled to make decisions at the bedside, based on experience, observational studies, and principles of hematology. We will provide an initial example that describes how a team-based, learning collaborative developed a multisite standard care protocol with a low budget (<$10 000 per year) to overcome the intrinsic limitations of advancing the care of neurologic complications in sickle cell disease (SCD)...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27912106/a-multicenter-randomized-controlled-trial-for-bright-light-therapy-in-adults-with-intellectual-disabilities-and-depression-study-protocol-and-obstacle-management
#3
Pauline C M Hamers, Heleen M Evenhuis, Heidi Hermans
Due to the limited cognitive and communicative abilities of adults with intellectual disabilities (ID), current treatment options for depression are often limited to lifestyle changes and pharmacological treatment. Bright light therapy (BLT) is an effective intervention for both seasonal and non-seasonal depression in the general population. BLT is an inexpensive, easy to carry out intervention with minimal side effects. However, knowledge on its anti-depressant effect in adults with ID is lacking. Obstacles in realizing a controlled intervention study in this particular study population may have contributed to this lack...
November 29, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27903561/keeping-weight-off-study-protocol-of-an-rct-to-investigate-brain-changes-associated-with-mindfulness-based-stress-reduction
#4
Carl Fulwiler, Julia A Siegel, Jeroan Allison, Milagros C Rosal, Judson Brewer, Jean A King
INTRODUCTION: Obesity is a growing epidemic fuelled by unhealthy behaviours and associated with significant comorbidities and financial costs. While behavioural interventions produce clinically meaningful weight loss, weight loss maintenance is challenging. This may partially be due to failure to target stress and emotional reactivity. Mindfulness-based stress reduction (MBSR) reduces stress and emotional reactivity and may be a useful tool for behaviour change maintenance. This study seeks to provide a mechanistic understanding for clinical trials of the benefits of MBSR for weight loss maintenance by examining changes in functional connectivity (FC) and the association of these changes with clinical outcomes...
November 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27900169/neuromuscular-exercise-and-back-counselling-for-female-nursing-personnel-with-recurrent-non-specific-low-back-pain-study-protocol-of-a-randomised-controlled-trial-nurse-rct
#5
Jaana H Suni, Marjo Rinne, Markku Kankaanpää, Annika Taulaniemi, Sirpa Lusa, Harri Lindholm, Jari Parkkari
INTRODUCTION: Nursing personnel have high risk for incidence of low back pain (LBP) followed by development of chronic pain and disability. Multiple risk factors such as patient handling, night shift work and lack of supporting work culture have been identified. In subacute LBP, high-fear avoidance is prognostic for more pain, disability and not returning to work. Lack of leisure-time physical activity predicts long-term sickness absence. The purpose of this study is to compare effectiveness of 6-month neuromuscular exercise and counselling in treating back pain in female nursing personnel with recurrent non-specific LBP pain compared with either (exercise or counselling) alone and a non-treatment control group...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27891666/a-systematic-review-of-the-outcomes-reported-in-trials-of-medication-review-in-older-patients-the-need-for-a-core-outcome-set
#6
Jean-Baptiste Beuscart, Lisa G Pont, Stefanie Thevelin, Benoit Boland, Olivia Dalleur, Anne Rutjes, Johanna I Westbrook, Anne Spinewine
AIM: Medication review has been advocated as one of the measures to tackle the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. This study aimed to assess outcome reporting in trials of medication review in older patients. METHODS: Randomized controlled trials (RCTs), prospective studies and RCT protocols involving medication review performed in patients aged 65 years or older in any setting of care were identified from: (1) a recent systematic review; (2) RCT registries of ongoing studies; (3) the Cochrane library...
November 27, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27887597/technology-enhanced-multi-domain-at-home-continuum-of-care-program-with-respect-to-usual-care-for-people-with-cognitive-impairment-the-ability-telerehabilitation-study-protocol-for-a-randomized-controlled-trial
#7
O Realdon, F Rossetto, M Nalin, I Baroni, M Cabinio, R Fioravanti, F L Saibene, M Alberoni, F Mantovani, M Romano, R Nemni, F Baglio
BACKGROUND: According to the World Alzheimer Report (Prince, The Global Impact of Dementia: an Analysis of Prevalence, Incidence, Cost and Trends, 2015), 46.8 million people worldwide are nowadays living with dementia. And this number is estimated to approximate 131.5 million by 2050, with an increasing burden on society and families. The lack of medical treatments able to stop or slow down the course of the disease has moved the focus of interest toward the nonpharmacological approach and psychosocial therapies for people with/at risk of dementia, as in the Mild Cognitive Impairment (MCI) condition...
November 25, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27884855/effectiveness-of-trauma-focused-psychological-therapies-compared-to-usual-postnatal-care-for-treating-post-traumatic-stress-symptoms-in-women-following-traumatic-birth-a-systematic-review-protocol
#8
Marie Furuta, Debbie Spain, Debra Bick, Edmond S W Ng, Jacqueline Sin
INTRODUCTION: Maternal mental health has been largely neglected in the literature. Women, however, may be vulnerable to developing post-traumatic stress symptoms or post-traumatic stress disorder (PTSD), following traumatic birth. In turn, this may affect their capacity for child rearing and ability to form a secure bond with their baby and impact on the wider family. Trauma-focused psychological therapies (TFPT) are widely regarded as effective and acceptable interventions for PTSD in general and clinical populations...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27884208/what-are-the-best-methodologies-for-rapid-reviews-of-the-research-evidence-for-evidence-informed-decision-making-in-health-policy-and-practice-a-rapid-review
#9
REVIEW
Michelle M Haby, Evelina Chapman, Rachel Clark, Jorge Barreto, Ludovic Reveiz, John N Lavis
BACKGROUND: Rapid reviews have the potential to overcome a key barrier to the use of research evidence in decision making, namely that of the lack of timely and relevant research. This rapid review of systematic reviews and primary studies sought to answer the question: What are the best methodologies to enable a rapid review of research evidence for evidence-informed decision making in health policy and practice? METHODS: This rapid review utilised systematic review methods and was conducted according to a pre-defined protocol including clear inclusion criteria (PROSPERO registration: CRD42015015998)...
November 25, 2016: Health Research Policy and Systems
https://www.readbyqxmd.com/read/27884137/early-identification-in-primary-health-care-of-people-at-risk-for-sick-leave-due-to-work-related-stress-study-protocol-of-a-randomized-controlled-trial-rct
#10
Kristina Holmgren, Christine Sandheimer, Ann-Charlotte Mårdby, Maria E H Larsson, Ute Bültmann, Dominique Hange, Gunnel Hensing
BACKGROUND: Early identification of persons at risk of sickness absence due to work-related stress is a crucial problem for society in general, and primary health care in particular. Tho date, no established method to do this exists. This project's aim is to evaluate whether systematic early identification of work-related stress can prevent sickness absence. This paper presents the study design, procedure and outcome measurements, as well as allocation and baseline characteristics of the study population...
November 25, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27881152/fitness-and-mobility-training-in-patients-with-intensive-care-unit-acquired-muscle-weakness-fitonicu-study-protocol-for-a-randomised-controlled-trial
#11
Jan Mehrholz, Simone Thomas, Jane H Burridge, André Schmidt, Bettina Scheffler, Ralph Schellin, Stefan Rückriem, Daniel Meißner, Katja Mehrholz, Wolfgang Sauter, Ulf Bodechtel, Bernhard Elsner
BACKGROUND: Critical illness myopathy (CIM) and polyneuropathy (CIP) are a common complication of critical illness. Both cause intensive-care-unit-acquired (ICU-acquired) muscle weakness (ICUAW) which increases morbidity and delays rehabilitation and recovery of activities of daily living such as walking ability. Focused physical rehabilitation of people with ICUAW is, therefore, of great importance at both an individual and a societal level. A recent systematic Cochrane review found no randomised controlled trials (RCT), and thus no supporting evidence, for physical rehabilitation interventions for people with defined CIP and CIM to improve activities of daily living...
November 24, 2016: Trials
https://www.readbyqxmd.com/read/27881108/study-protocol-for-a-non-inferiority-trial-of-a-blended-smoking-cessation-treatment-versus-face-to-face-treatment-livesmokefree-study
#12
Lutz Siemer, Marcel E Pieterse, Marjolein G J Brusse-Keizer, Marloes G Postel, Somaya Ben Allouch, Robbert Sanderman
BACKGROUND: Smoking cessation can significantly reduce the risk of developing smoking-related diseases. Several face-to-face and web-based treatments have shown to be effective. Blending of web-based and face-to-face treatment is expected to improve smoking cessation treatment. The primary objective of this study is to compare the prolonged abstinence rate of the blended smoking cessation treatment with the face-to-face treatment. Secondary objectives are to assess the benefits of blended treatment in terms of cost effectiveness and patient satisfaction, and to identify mechanisms underlying successful smoking cessation...
November 24, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27876082/evaluating-data-abstraction-assistant-a-novel-software-application-for-data-abstraction-during-systematic-reviews-protocol-for-a-randomized-controlled-trial
#13
Ian J Saldanha, Christopher H Schmid, Joseph Lau, Kay Dickersin, Jesse A Berlin, Jens Jap, Bryant T Smith, Simona Carini, Wiley Chan, Berry De Bruijn, Byron C Wallace, Susan M Hutfless, Ida Sim, M Hassan Murad, Sandra A Walsh, Elizabeth J Whamond, Tianjing Li
BACKGROUND: Data abstraction, a critical systematic review step, is time-consuming and prone to errors. Current standards for approaches to data abstraction rest on a weak evidence base. We developed the Data Abstraction Assistant (DAA), a novel software application designed to facilitate the abstraction process by allowing users to (1) view study article PDFs juxtaposed to electronic data abstraction forms linked to a data abstraction system, (2) highlight (or "pin") the location of the text in the PDF, and (3) copy relevant text from the PDF into the form...
November 22, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27863027/pacifier-use-and-interruption-of-exclusive-breastfeeding-systematic-review-and-meta-analysis
#14
REVIEW
Gabriela Dos Santos Buccini, Rafael Pérez-Escamilla, Larissa Munari Paulino, Clarice Lopes Araújo, Sonia Isoyama Venancio
Identifying modifiable risk factor for exclusive breastfeeding (EBF) interruption is key for improving child health globally. There is no consensus about the effect of pacifier use on EBF interruption. Thus, the aim of this systematic review was to investigate the association between pacifier use and EBF interruption during the first six month. A search of CINAHL, Scopus, Web of Science, LILACS and Medline; from inception through 30 December 2014 without restriction of language yielded 1,866 publications (PROSPERO protocol CRD42014014527)...
November 14, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27855719/an-illness-focused-interactive-booklet-to-optimise-management-and-medication-for-childhood-fever-and-infections-in-out-of-hours-primary-care-study-protocol-for-a-cluster-randomised-trial
#15
Eefje G P M de Bont, Geert-Jan Dinant, Gijs Elshout, Gijs van Well, Nick A Francis, Bjorn Winkens, Jochen W L Cals
BACKGROUND: Fever is the most common reason for a child to be taken to a general practitioner (GP), especially during out-of-hours care. It is mostly caused by self-limiting infections. However, antibiotic prescription rates remain high, especially during out-of-hours care. Anxiety and lack of knowledge among parents, and perceived pressure to prescribe antibiotics amongst GPs, are important determinants of excessive antibiotic prescriptions. An illness-focused interactive booklet has the potential to improve this by providing parents with information about fever self-management strategies...
November 17, 2016: Trials
https://www.readbyqxmd.com/read/27855109/bathing-adaptations-in-the-homes-of-older-adults-bath-out-protocol-for-a-feasibility-randomised-controlled-trial-rct
#16
Phillip J Whitehead, Marilyn James, Stuart Belshaw, Tony Dawson, Miriam R Day, Marion F Walker
INTRODUCTION: The Care Act 2014 has placed a responsibility on local authorities in England to provide services that prevent deterioration and minimise the use of other health and social care services. Housing adaptations have been identified as 1 of the 10 most promising prevention services for older adults, with bathing adaptations being the most requested. However, many local authorities have lengthy waiting times which may increase costs, reduce effectiveness and reduce the preventive effect...
October 6, 2016: BMJ Open
https://www.readbyqxmd.com/read/27852295/evaluation-of-a-school-based-depression-prevention-program-among-adolescents-with-elevated-depressive-symptoms-study-protocol-of-a-randomized-controlled-trial
#17
Karlijn W J de Jonge-Heesen, Kim M van Ettekoven, Sanne P A Rasing, Farina H J Oprins-van Liempd, Ad A Vermulst, Rutger C M E Engels, Daan H M Creemers
BACKGROUND: Adolescents are at risk of developing depressive symptoms. Given the prevalence, recurrence and negative consequences of adolescent depression, it is crucial to implement prevention programs for high-risk adolescents. Prevention programs at an indicated level have shown to be successful in reducing depressive symptoms in adolescents. This study will evaluate the (cost)effectiveness of the prevention program 'Op Volle Kracht (OVK 2.0)' for adolescents with elevated depressive symptoms...
November 16, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27849287/effects-of-comprehensive-cardiac-rehabilitation-on-functional-capacity-and-cardiovascular-risk-factors-in-brazilians-assisted-by-public-health-care-protocol-for-a-randomized-controlled-trial
#18
Gabriela S S Chaves, Gabriela L M Ghisi, Sherry L Grace, Paul Oh, Antonio L Ribeiro, Raquel R Britto
Background: Cardiovascular Disease (CVD) is the leading burden of disease worldwide. Moreover, CVD-related death rates are considered an epidemic in low- and middle-income countries (LMICs). Research shows that cardiac rehabilitation (CR) participation reduces death and improves disability and quality of life. Given the growing epidemic of CVD in LMICs and the insufficient evidence about CR programs in these countries, a Randomized Control Trial (RCT) in Latin America is warranted. Objective: To investigate the effects of comprehensive CR on functional capacity and cardiovascular risk factors...
October 27, 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/27847352/the-effects-of-an-e-mental-health-program-and-job-coaching-on-the-risk-of-major-depression-and-productivity-in-canadian-male-workers-protocol-for-a-randomized-controlled-trial
#19
JianLi Wang, Scott B Patten, Raymond W Lam, Mark Attridge, Kendall Ho, Norbert Schmitz, Alain Marchand, Bonnie M Lashewicz
BACKGROUND: Major depression (MDE) is prevalent in men and affects men's health and productivity. Because of the stigma against depression and social/gender norms, men are less likely to seek help for emotion and stress-related issues. Therefore, innovative solutions tailored for men are needed. With rapid development of the Internet and information technologies, one promising solution that has drawn considerable attentions is electronic mental (e-mental) health programs and services...
November 15, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27843743/comparison-of-a-robotic-assisted-gait-training-program-with-a-program-of-functional-gait-training-for-children-with-cerebral-palsy-design-and-methods-of-a-two-group-randomized-controlled-cross-over-trial
#20
Alicia J Hilderley, Darcy Fehlings, Gloria W Lee, F Virginia Wright
BACKGROUND: Enhancement of functional ambulation is a key goal of rehabilitation for children with cerebral palsy (CP) who experience gross motor impairment. Physiotherapy (PT) approaches often involve overground and treadmill-based gait training to promote motor learning, typically as free walking or with body-weight support. Robotic-assisted gait training (RAGT), using a device such as the Lokomat(®)Pro, may permit longer training duration, faster and more variable gait speeds, and support walking pattern guidance more than overground/treadmill training to further capitalize on motor learning principles...
2016: SpringerPlus
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