keyword
MENU ▼
Read by QxMD icon Read
search

RCT protocol

keyword
https://www.readbyqxmd.com/read/28639551/facet-joint-injections-for-people-with-persistent-non-specific-low-back-pain-facet-injection-study-a-feasibility-study-for-a-randomised-controlled-trial
#1
David R Ellard, Martin Underwood, Felix Achana, James Hl Antrobus, Shyam Balasubramanian, Sally Brown, Melinda Cairns, James Griffin, Frances Griffiths, Kirstie Haywood, Charles Hutchinson, Ranjit Lall, Stavros Petrou, Nigel Stallard, Colin Tysall, David A Walsh, Harbinder Sandhu
BACKGROUND: The National Institute for Health and Care Excellence (NICE) 2009 guidelines for persistent low back pain (LBP) do not recommend the injection of therapeutic substances into the back as a treatment for LBP because of the absence of evidence for their effectiveness. This feasibility study aimed to provide a stable platform that could be used to evaluate a randomised controlled trial (RCT) on the clinical effectiveness and cost-effectiveness of intra-articular facet joint injections (FJIs) when added to normal care...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28639007/is-electroconvulsive-therapy-an-evidence-based-treatment-for-catatonia-a-systematic-review-and-meta-analysis
#2
Arnaud Leroy, Florian Naudet, Guillaume Vaiva, Andrew Francis, Pierre Thomas, Ali Amad
We aimed to review and discuss the evidence-based arguments for the efficacy of electroconvulsive therapy (ECT) in the treatment of catatonia. Randomized controlled trials (RCTs) and observational studies focusing on the response to ECT in catatonia were selected in PubMed, the Cochrane Library, Embase, ClinicalTrials.gov and Current Controlled Trials through October 2016 and qualitatively described. Trials assessing pre-post differences using a catatonia or clinical improvement rating scale were pooled together using a random effect model...
June 21, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28637740/tablet-computers-versus-optical-aids-to-support-education-and-learning-in-children-and-young-people-with-low-vision-protocol-for-a-pilot-randomised-controlled-trial-create-children-reading-with-electronic-assistance-to-educate
#3
Michael D Crossland, Rachel Thomas, Hilary Unwin, Seelam Bharani, Vijaya K Gothwal, Ana Quartilho, Catey Bunce, Annegret Dahlmann-Noor
INTRODUCTION: Low vision and blindness adversely affect education and independence of children and young people. New 'assistive' technologies such as tablet computers can display text in enlarged font, read text out to the user, allow speech input and conversion into typed text, offer document and spreadsheet processing and give access to wide sources of information such as the internet. Research on these devices in low vision has been limited to case series. METHODS AND ANALYSIS: We will carry out a pilot randomised controlled trial (RCT) to assess the feasibility of a full RCT of assistive technologies for children/young people with low vision...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28627356/aquatic-therapy-for-children-with-duchenne-muscular-dystrophy-a-pilot-feasibility-randomised-controlled-trial-and-mixed-methods-process-evaluation
#4
Daniel Hind, James Parkin, Victoria Whitworth, Saleema Rex, Tracey Young, Lisa Hampson, Jennie Sheehan, Chin Maguire, Hannah Cantrill, Elaine Scott, Heather Epps, Marion Main, Michelle Geary, Heather McMurchie, Lindsey Pallant, Daniel Woods, Jennifer Freeman, Ellen Lee, Michelle Eagle, Tracey Willis, Francesco Muntoni, Peter Baxter
BACKGROUND: Duchenne muscular dystrophy (DMD) is a rare disease that causes the progressive loss of motor abilities such as walking. Standard treatment includes physiotherapy. No trial has evaluated whether or not adding aquatic therapy (AT) to land-based therapy (LBT) exercises helps to keep muscles strong and children independent. OBJECTIVES: To assess the feasibility of recruiting boys with DMD to a randomised trial evaluating AT (primary objective) and to collect data from them; to assess how, and how well, the intervention and trial procedures work...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28625821/the-use-of-study-registration-and-protocols-in-plastic-surgery-research-a-systematic-review
#5
REVIEW
Thomas Edward Pidgeon, Christopher Limb, Riaz A Agha, Katharine Whitehurst, Charmilie Chandrakumar, Georgina Wellstead, Alexander J Fowler, Dennis P Orgill
BACKGROUND: In 2013, the Declaration of Helsinki changed to mandate that all research studies involving human subjects must have a protocol registered in a publicly accessible database prior to the enrolment of the first patient, rather than just clinical trials. The objective of this work was to assess the number of research studies involving human participants published in leading journals of plastic surgery that had either published or registered a protocol with a publicly accessible database...
June 15, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28625282/high-intensity-exercise-training-for-improving-reproductive-function-in-infertile-patients-a-randomized-controlled-trial
#6
Behzad Hajizadeh Maleki, Bakhtyar Tartibian
OBJECTIVE: The purpose of this RCT was to investigate whether a 24-week program of high-intensity exercise was beneficial for improving reproductive function in infertile male patients. METHODS: Infertile men (n = 433) were randomly assigned to exercise (n = 218) and non-exercise (n = 215) groups. The seminal markers of inflammation and oxidative stress, semen quality parameters, sperm DNA fragmentation, and pregnancy rate were measured at baseline, at the end of week 12, at the end of week 24, and at 7 and 30 days during recovery...
July 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28619777/peripherally-inserted-central-catheter-dressing-and-securement-in-patients-with-cancer-the-pisces-trial-protocol-for-a-2x2-factorial-superiority-randomised-controlled-trial
#7
Claire M Rickard, Nicole M Marsh, Joan Webster, Nicole C Gavin, Raymond J Chan, Alexandra L McCarthy, Peter Mollee, Amanda J Ullman, Tricia Kleidon, Vineet Chopra, Li Zhang, Matthew R McGrail, Emily Larsen, Md Abu Choudhury, Samantha Keogh, Evan Alexandrou, David J McMillan, Merehau Cindy Mervin, David L Paterson, Marie Cooke, Gillian Ray-Barruel, Maria Isabel Castillo, Andrew Hallahan, Amanda Corley, E Geoffrey Playford
INTRODUCTION: Around 30% of peripherally inserted central catheters (PICCs) fail from vascular, infectious or mechanical complications. Patients with cancer are at highest risk, and this increases morbidity, mortality and costs. Effective PICC dressing and securement may prevent PICC failure; however, no large randomised controlled trial (RCT) has compared alternative approaches. We designed this RCT to assess the clinical and cost-effectiveness of dressing and securements to prevent PICC failure...
June 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28619126/health-and-wellbeing-outcomes-of-programs-for-indigenous-australians-that-include-strategies-to-enable-the-expression-of-cultural-identities-a-systematic-review
#8
Sarah MacLean, Rebecca Ritte, Alister Thorpe, Shaun Ewen, Kerry Arabena
Indigenous people have long maintained that strong cultural identities are critical to health and wellbeing. The purpose of this systematic review is to examine whether interventions that entail strategies to enable expression of cultural identities for Australian Indigenous peoples are associated with measurable improvements in health and wellbeing. Peer-reviewed articles that reported quantitatively expressed health and wellbeing outcomes involving Indigenous Australian participants only were included. The cultural intervention component was defined and assessed by Indigenous researchers on the team...
June 16, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28619078/psychological-interventions-for-the-treatment-of-depression-anxiety-alcohol-misuse-or-anger-in-armed-forces-veterans-and-their-families-systematic-review-and-meta-analysis-protocol
#9
Luke O'Shea, Ed Watkins, Paul Farrand
BACKGROUND: Evidence highlights a high prevalence of common mental health disorders in armed forces veterans and their families, with depression, anxiety, alcohol misuse and anger being more common than PTSD. This paper presents a protocol for a systematic review and meta-analysis to identify existing randomised controlled trial (RCT) research testing the effectiveness of psychological interventions for these difficulties in armed forces veterans and their family members. METHODS: Electronic databases (CENTRAL, PsycInfo, MEDLINE, CINAHL, The Cochrane Register of Clinical Trials, EMBASE and ASSIA) will be searched to identify suitable studies for inclusion in the review supplemented by forward and backward reference checking, grey literature searches and contact with subject authors...
June 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28606907/first-line-support-for-assistance-in-breathing-in-children-first-abc-protocol-for-a-multicentre-randomised-feasibility-trial-of-non-invasive-respiratory-support-in-critically-ill-children
#10
Padmanabhan Ramnarayan, Paula Lister, Troy Dominguez, Parviz Habibi, Naomi Edmonds, Ruth Canter, Paul Mouncey, Mark J Peters
INTRODUCTION: Over 18 000 children are admitted annually to UK paediatric intensive care units (PICUs), of whom nearly 75% receive respiratory support (invasive and/or non-invasive). Continuous positive airway pressure (CPAP) has traditionally been used to provide first-line non-invasive respiratory support (NRS) in PICUs; however, high-flow nasal cannula therapy (HFNC), a novel mode of NRS, has recently gained popularity despite the lack of high-quality trial evidence to support its effectiveness...
June 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28606102/choosing-the-target-difference-effect-size-for-a-randomised-controlled-trial-delta-2-guidance-protocol
#11
Jonathan A Cook, Steven A Julious, William Sones, Joanne C Rothwell, Craig R Ramsay, Lisa V Hampson, Richard Emsley, Stephen J Walters, Catherine Hewitt, Martin Bland, Dean A Fergusson, Jesse A Berlin, Doug Altman, Luke D Vale
BACKGROUND: A key step in the design of a randomised controlled trial (RCT) is the estimation of the number of participants needed. By far the most common approach is to specify a target difference and then estimate the corresponding sample size; this sample size is chosen to provide reassurance that the trial will have high statistical power to detect such a difference between the randomised groups (at the planned statistical significance level). The sample size has many implications for the conduct of the study, as well as carrying scientific and ethical aspects to its choice...
June 12, 2017: Trials
https://www.readbyqxmd.com/read/28605230/effects-of-structured-exercise-interventions-for-older-adults-hospitalized-with-acute-medical-illness-a-systematic-review
#12
Frances A Kanach, Amy M Pastva, Katherine S Hall, Juliessa M Pavon, Miriam C Morey
This review examined effects of structured exercise (aerobic walking, with or without complementary modes of exercise) on cardiorespiratory measures, mobility, functional status, healthcare utilization, and Quality of Life in older adults (≥60 years) hospitalized for acute medical illness. Inclusion required exercise protocol, at least one patient-level or utilization outcome, and at least one physical assessment point during hospitalization or within 1 month of intervention. MEDLINE, Embase, and CINAHL databases were searched for studies published from 2000 to March 2015...
June 12, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28603552/problem-management-plus-pm-in-the-management-of-common-mental-disorders-in-a-specialized-mental-healthcare-facility-in-pakistan-study-protocol-for-a-randomized-controlled-trial
#13
Syed Usman Hamdani, Zainab Ahmed, Marit Sijbrandij, Huma Nazir, Aqsa Masood, Parveen Akhtar, Hania Amin, Richard A Bryant, Katie Dawson, Mark van Ommeren, Atif Rahman, Fareed Aslam Minhas
BACKGROUND: The World Health Organization (WHO) has developed Problem Management Plus (PM+), a 5-session, psychological intervention program delivered by trained non-specialist that addresses common mental disorders. The objectives of this study are to evaluate effectiveness and cost-effectiveness of PM+ in a specialized mental health care facility in Pakistan. METHODS: A single blind individual randomized controlled trial (RCT) will be carried out in the outpatient department of a specialized mental healthcare facility in Rawalpindi, Pakistan...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28603349/neural-manual-vs-robotic-assisted-mobilization-to-improve-motion-and-reduce-pain-hypersensitivity-in-hand-osteoarthritis-study-protocol-for-a-randomized-controlled-trial
#14
Jorge Hugo Villafañe, Kristin Valdes, Grace Imperio, Alberto Borboni, Raquel Cantero-Téllez, Silvia Galeri, Stefano Negrini
[Purpose] The aim of the present study is to detail the protocol for a randomised controlled trial (RCT) of neural manual vs. robotic assisted on pain in sensitivity as well as analyse the quantitative and qualitative movement of hand in subjects with hand osteoarthritis. [Subjects and Methods] Seventy-two patients, aged 50 to 90 years old of both genders, with a diagnosis of hand Osteoarthritis (OA), will be recruited. Two groups of 36 participants will receive an experimental intervention (neurodynamic mobilization intervention plus exercise) or a control intervention (robotic assisted passive mobilization plus exercise) for 12 sessions over 4 weeks...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28603007/the-precis-2-tool-has-good-inter-rater-reliability-and-reasonable-discriminant-validity
#15
Kirsty Loudon, Merrick Zwarenstein, Frank Sullivan, Peter Donnan, Ildikó Gágyor, Hans Hobbelen, Fernando Althabe, Jerry A Krishnan, Shaun Treweek
OBJECTIVE: PRECIS - 2 is a tool that could improve design insight for trialists. Our aim was to validate the PRECIS - 2 tool, unlike its predecessor, testing the discriminant validity and inter-rater reliability. STUDY DESIGN AND SETTING: Over 80 international trialists, methodologists, clinicians and policymakers created PRECIS - 2 helping to ensure face and content validity. The inter-rater reliability of PREC IS - 2 was measured using 19 experienced trialists who used PRECIS - 2 to score a diverse sample of 15 RCT protocols...
June 8, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28595611/video-game-rehabilitation-for-outpatient-stroke-vigorous-protocol-for-a-multi-center-comparative-effectiveness-trial-of-in-home-gamified-constraint-induced-movement-therapy-for-rehabilitation-of-chronic-upper-extremity-hemiparesis
#16
Lynne V Gauthier, Chelsea Kane, Alexandra Borstad, Nancy Strahl, Gitendra Uswatte, Edward Taub, David Morris, Alli Hall, Melissa Arakelian, Victor Mark
BACKGROUND: Constraint-Induced Movement therapy (CI therapy) is shown to reduce disability, increase use of the more affected arm/hand, and promote brain plasticity for individuals with upper extremity hemiparesis post-stroke. Randomized controlled trials consistently demonstrate that CI therapy is superior to other rehabilitation paradigms, yet it is available to only a small minority of the estimated 1.2 million chronic stroke survivors with upper extremity disability. The current study aims to establish the comparative effectiveness of a novel, patient-centered approach to rehabilitation utilizing newly developed, inexpensive, and commercially available gaming technology to disseminate CI therapy to underserved individuals...
June 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28580164/mindfulness-based-cognitive-therapy-mbct-programme-for-depression-in-people-with-early-stages-of-dementia-study-protocol-for-a-randomised-controlled-feasibility-study
#17
Elisa Aguirre, Josh Stott, Georgina Charlesworth, Deirdre Noone, Jacob Payne, Mina Patel, Aimee Spector
BACKGROUND: Depression and dementia are major public health problems in the UK. Depression in early-stage dementia is very common and significantly reduces quality of life, speeds cognitive decline and increases functional impairment. Mindfulness-Based Cognitive Therapy (MBCT) is an effective depression prevention programme, and the National Institute for Clinical Excellence (NICE) has suggested that MBCT is a priority for implementation. Alongside this, there is emerging evidence demonstrating promising results in relation to the benefits of adapted mindfulness interventions for people with dementia, suggesting that it could be beneficial in reducing depressive symptoms and in slowing deterioration in cognitive functions such as sustained attention, distraction inhibition and task switching...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28578652/icorg-10-14-neoadjuvant-trial-in-adenocarcinoma-of-the-oesophagus-and-oesophagogastric-junction-international-study-neo-aegis
#18
J V Reynolds, S R Preston, B O'Neill, L Baeksgaard, S M Griffin, C Mariette, S Cuffe, M Cunningham, T Crosby, I Parker, K Hofland, G Hanna, L B Svendsen, C L Donohoe, C Muldoon, D O'Toole, C Johnson, N Ravi, G Jones, A K Corkhill, M Illsley, J Mellor, K Lee, M Dib, V Marchesin, M Cunnane, K Scott, P Lawner, S Warren, S O'Reilly, G O'Dowd, G Leonard, B Hennessy, R Mc Dermott
BACKGROUND: Neoadjuvant therapy is increasingly the standard of care in the management of locally advanced adenocarcinoma of the oesophagus and junction (AEG). In randomised controlled trials (RCTs), the MAGIC regimen of pre- and postoperative chemotherapy, and the CROSS regimen of preoperative chemotherapy combined with radiation, were superior to surgery only in RCTs that included AEG but were not powered on this cohort. No completed RCT has directly compared neoadjuvant or perioperative chemotherapy and neoadjuvant chemoradiation...
June 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28559225/home-based-hiv-testing-and-counseling-for-male-couples-project-nexus-a-protocol-for-a-randomized-controlled-trial
#19
Rob Stephenson, Ryan Freeland, Stephen P Sullivan, Erin Riley, Brent A Johnson, Jason Mitchell, Deborah McFarland, Patrick S Sullivan
BACKGROUND: HIV prevalence remains high among men who have sex with men (MSM) in the United States, yet the majority of research has focused on MSM as individuals, not as dyads, and has discussed HIV risks primarily in the context of casual sex. Nexus is an online prevention program that combines home-based HIV testing and couples HIV testing and counseling (CHTC). It allows partners in dyadic MSM relationships to receive HIV testing and care in the comfort of their designated residence, via video-based chat...
May 30, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28552331/effects-of-neurofeedback-on-the-short-term-memory-and-continuous-attention-of-patients-with-moderate-traumatic-brain-injury-a-preliminary-randomized-controlled-clinical-trial
#20
Reza Rostami, Payman Salamati, Kourosh Karimi Yarandi, Alireza Khoshnevisan, Soheil Saadat, Zeynab Sadat Kamali, Somaie Ghiasi, Atefeh Zaryabi, Seyed Shahab Ghazi Mir Saeid, Mehdi Arjipour, Mohammad Saeid Rezaee-Zavareh, Vafa Rahimi-Movaghar
PURPOSE: There are some studies which showed neurofeedback therapy (NFT) can be effective in clients with traumatic brain injury (TBI) history. However, randomized controlled clinical trials are still needed for evaluation of this treatment as a standard option. This preliminary study was aimed to evaluate the effect of NFT on continuous attention (CA) and short-term memory (STM) of clients with moderate TBI using a randomized controlled clinical trial (RCT). METHODS: In this preliminary RCT, seventeen eligible patients with moderate TBI were randomly allocated in two intervention and control groups...
May 18, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
keyword
keyword
33855
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"