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https://www.readbyqxmd.com/read/29666432/genetic-validation-of-bipolar-disorder-identified-by-automated-phenotyping-using-electronic-health-records
#1
Chia-Yen Chen, Phil H Lee, Victor M Castro, Jessica Minnier, Alexander W Charney, Eli A Stahl, Douglas M Ruderfer, Shawn N Murphy, Vivian Gainer, Tianxi Cai, Ian Jones, Carlos N Pato, Michele T Pato, Mikael Landén, Pamela Sklar, Roy H Perlis, Jordan W Smoller
Bipolar disorder (BD) is a heritable mood disorder characterized by episodes of mania and depression. Although genomewide association studies (GWAS) have successfully identified genetic loci contributing to BD risk, sample size has become a rate-limiting obstacle to genetic discovery. Electronic health records (EHRs) represent a vast but relatively untapped resource for high-throughput phenotyping. As part of the International Cohort Collection for Bipolar Disorder (ICCBD), we previously validated automated EHR-based phenotyping algorithms for BD against in-person diagnostic interviews (Castro et al...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29664482/my-hypertension-education-and-reaching-target-myheart-development-and-dissemination-of-a-patient-centered-website-for-young-adults-with-hypertension
#2
Heather M Johnson, Jamie N LaMantia, Colleen M Brown, Ryan C Warner, Laura M Zeller, Ryan C Haggart, Keven Stonewall, Diane R Lauver
Background: Young adults (18 to 39 years old) with hypertension have the lowest rates of blood pressure control (defined as blood pressure less than 140/90 mmHg) compared to other adult age groups. Approximately 1 in 15 young adults have high blood pressure, increasing their risk of future heart attack, stroke, congestive heart failure, and/or chronic kidney disease. Many young adults reported having few resources to address their needs for health education on managing cardiovascular risk...
July 2017: JMIR cardio
https://www.readbyqxmd.com/read/29662689/supporting-the-development-of-a-health-benefits-package-in-malawi
#3
Jessica Ochalek, Paul Revill, Gerald Manthalu, Finn McGuire, Dominic Nkhoma, Alexandra Rollinger, Mark Sculpher, Karl Claxton
Malawi, like many low-income and middle-income countries, has used health benefits packages (HBPs) to allocate scarce resources to key healthcare interventions. With no widely accepted method for their development, HBPs often promise more than can be delivered, given available resources. An analytical framework is developed to guide the design of HBPs that can identify the potential value of including and implementing different interventions. It provides a basis for informing meaningful discussions between governments, donors and other stakeholders around the trade-offs implicit in package design...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29653218/comparing-ran-out-status-of-inhaled-short-acting-beta-agonists-in-emergency-department-patients-with-acute-asthma-1996-1998-versus-2015-2017
#4
Tadahiro Goto, Carlos A Camargo, Catalina Gimenez-Zapiola, Daniel J Pallin, Nathan I Shapiro, Thomas J Ferro, Carolyn Rainville, Stanislav Stoyanov, Kohei Hasegawa
BACKGROUND: Medication non-adherence including running out of inhaled asthma medications, is an important problem. OBJECTIVE: To examine the changes in the proportion of adults with acute asthma who ran out of their short-acting beta-agonist (SABA) inhalers before presenting to the emergency department (ED) between 1996-1998 and 2015-2017. METHODS: We analyzed data from prospective multicenter observational cohort studies of ED adult patients (aged 18-54 years) with acute asthma...
April 10, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29650592/using-q-methodology-to-guide-the-implementation-of-new-healthcare-policies
#5
Sarah Alderson, Robbie Foy, Louise Bryant, Shenaz Ahmed, Allan House
There are many challenges in the development, implementation and evaluation of healthcare policy. One challenge is understanding how different stakeholders view a particular policy and what impact these views may have during implementation. Q-methodology is one approach that can be used to help policy makers and researchers actively engage with those who are important in policy implementation, and anticipate their responses. Q-methodology combines qualitative and quantitative research methods to systematically explore and describe the range of viewpoints about a topic...
April 12, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29650189/islamic-moral-judgement-on-abortion-and-its-nursing-applications-expository-analysis
#6
Mohamad Firdaus Mohamad Ismail, Abdurezak Abdullahi Hashi, Mohd Said Bin Nurumal, Muhammad Lokman Bin Md Isa
Health workers, like nurses are tasked to save the lives of their patients, however, there are instances in which health workers have to deal with difficult cases in taking a life, such as abortion. Scholars in the field of healthcare assert that abortion is morally justified if it is sought for health reasons. Nevertheless, there are a number of cases in which abortion is sought on other grounds other than health, such as the individual choice to do so. Can a nurse refuse to provide their professional service towards these people? This paper uses analytical and comparative methods to address ethical issues in abortion from the Islamic and conventional perspectives...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29629190/antibiotics-and-activity-spaces-protocol-of-an-exploratory-study-of-behaviour-marginalisation-and-knowledge-diffusion
#7
Marco J Haenssgen, Nutcha Charoenboon, Giacomo Zanello, Mayfong Mayxay, Felix Reed-Tsochas, Caroline O H Jones, Romyen Kosaikanont, Pollavat Praphattong, Pathompong Manohan, Yoel Lubell, Paul N Newton, Sommay Keomany, Heiman F L Wertheim, Jeffrey Lienert, Thipphaphone Xayavong, Penporn Warapikuptanun, Yuzana Khine Zaw, Patchapoom U-Thong, Patipat Benjaroon, Narinnira Sangkham, Kanokporn Wibunjak, Poowadon Chai-In, Sirirat Chailert, Patthanan Thavethanutthanawin, Krittanon Promsutt, Amphayvone Thepkhamkong, Nicksan Sithongdeng, Maipheth Keovilayvanh, Nid Khamsoukthavong, Phaengnitta Phanthasomchit, Chanthasone Phanthavong, Somsanith Boualaiseng, Souksakhone Vongsavang, Rachel C Greer, Thomas Althaus, Supalert Nedsuwan, Daranee Intralawan, Tri Wangrangsimakul, Direk Limmathurotsakul, Proochista Ariana
Background: Antimicrobial resistance (AMR) is a global health priority. Leading UK and global strategy papers to fight AMR recognise its social and behavioural dimensions, but current policy responses to improve the popular use of antimicrobials (eg, antibiotics) are limited to education and awareness-raising campaigns. In response to conceptual, methodological and empirical weaknesses of this approach, we study people's antibiotic-related health behaviour through three research questions...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29629042/depression-anxiety-and-perceived-social-support-among-adults-with-beta-thalassemia-major-cross-sectional-study
#8
Aghbabak Maheri, Roya Sadeghi, Davoud Shojaeizadeh, Azar Tol, Mehdi Yaseri, Alireza Rohban
Background: Considering the high prevalence of depression and anxiety among thalassemia patients and the role of social support in preventing mental disorders, this study aimed to determine prevalence of depression, anxiety, and perceived social support (PSS) among adults with beta-thalassemia major. Methods: This cross-sectional study was performed with 389 adults with beta-thalassemia major. Data were collected via a questionnaire consisting of three parts: demographic and medical information, the Persian version of the hospital anxiety and depression scale, and the Persian version of the Multidimensional Scale of Perceived Social Support...
March 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29627815/protocol-for-a-mixed-methods-study-of-hospital-readmissions-sensemaking-in-veterans-health-administration-healthcare-system-in-the-usa
#9
Lauren S Penney, Luci K Leykum, Polly Noël, Erin P Finley, Holly Jordan Lanham, Jacqueline Pugh
INTRODUCTION: Effective delivery of healthcare in complex systems requires managing interdependencies between professions and organisational units. Reducing 30-day hospital readmissions may be one of the most complex tasks that a healthcare system can undertake. We propose that these less than optimal outcomes are related to difficulties managing the complex interdependencies among organisational units and to a lack of effective sensemaking among individuals and organisational units regarding how best to coordinate patient needs...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29625768/human-papillomavirus-vaccine-acceptability-and-decision-making-among-adolescent-boys-and-parents-a-meta-ethnography-of-qualitative-studies
#10
REVIEW
Ashley Lacombe-Duncan, Peter A Newman, Philip Baiden
OBJECTIVE: Genital warts and human papillomavirus (HPV)-associated cancers in men can be substantially reduced through HPV vaccination; yet, globally, HPV vaccine uptake among boys remains low. This meta-ethnography synthesizes qualitative studies to understand, in-depth, HPV vaccine acceptability and decision-making among adolescent boys and/or their parents. METHODS: A systematic search identified qualitative studies examining HPV vaccines from the perspectives of boys and/or boys' parents...
April 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29624136/how-hospital-survey-teams-function
#11
Alan Boyd, Shilpa Ross, Ruth Robertson, Kieran Walshe, Rachael Smithson
Purpose The purpose of this paper is to understand how inspection team members work together to conduct surveys of hospitals, the challenges teams may face and how these might be addressed. Design/methodology/approach Data were gathered through an evaluation of a new regulatory model for acute hospitals in England, implemented by the Care Quality Commission (CQC) during 2013-2014. The authors interviewed key stakeholders, observed inspections and surveyed and interviewed inspection team members and hospital staff...
April 9, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29623571/introducing-students-of-color-to-health-sciences-research-an-evaluation-of-the-health-disparities-summer-internship-program
#12
Nicole A McLean, Marilyn Fraser, Nicole A Primus, Michael A Joseph
The goal of this analysis is to assess the effectiveness of a summer program designed to introduce high school students of color to health disparities research. A total of 73 students (69.9% Black, 68.5% female and 80.6% either junior/senior) participated in the 4-week Health Disparities Summer Internship Program (HDSIP) during the years 2012-2015. Students attended lectures covering topics such as health disparities, community-based participatory research (CBPR), immigrant health, and policy and advocacy. While working with community-based organizations, students gained hands-on experience related to issues discussed in class...
April 5, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29621248/adherence-to-rivaroxaban-versus-apixaban-among-patients-with-non-valvular-atrial-fibrillation-analysis-of-overall-population-and-subgroups-of-prior-oral-anticoagulant-users
#13
Colleen A McHorney, Concetta Crivera, François Laliberté, Guillaume Germain, Willy Wynant, Patrick Lefebvre
BACKGROUND: Medication non-adherence can result in poor health outcomes. Understanding differences in adherence rates to non-vitamin K oral anticoagulants (NOACs) could guide treatment decisions and improve clinical outcomes among patients with non-valvular atrial fibrillation (NVAF). OBJECTIVE: To compare adherence to rivaroxaban and apixaban among the overall NVAF population and subgroups of prior oral anticoagulant (OAC) users (e.g., multiple comorbidities, non-adherence risk factors)...
2018: PloS One
https://www.readbyqxmd.com/read/29619585/exploring-treatment-needs-and-expectations-for-people-living-with-hiv-in-south-africa-a-qualitative-study
#14
Valerie A Earnshaw, Laura M Bogart, Ingrid Courtney, Holly Zanoni, David R Bangsberg, Catherine Orrell, Kathy Goggin, Ingrid T Katz
The UNAIDS 90-90-90 treatment targets aim to dramatically increase the number of people who initiate antiretroviral therapy (ART) by 2020. Greater understanding of barriers to ART initiation in high prevalence countries like South Africa is critical. Qualitative semi-structured interviews were conducted with 30 participants in Gugulethu Township, South Africa, including 10 healthcare providers and 20 people living with HIV (PLWH) who did not initiate ART. Interviews explored barriers to ART initiation and acceptability of theory-based intervention strategies to optimize ART initiation...
April 4, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29617884/rituximab-versus-the-modified-ponticelli-regimen-in-the-treatment-of-primary-membranous-nephropathy-a-health-economic-model
#15
Patrick Hamilton, Durga Kanigicherla, Michael Venning, Paul Brenchley, David Meads
Background: Membranous nephropathy is among the most common causes of nephrotic syndrome worldwide, with a high healthcare burden. Treatment using the modified Ponticelli regimen (mPR) has remained the standard of care for decades, but newer therapies such as rituximab offer promising results with reduced side effects. The cost of this treatment, however, is perceived as a barrier to widespread use, especially in resource limited healthcare systems. Methods: We developed a decision-analytic model to estimate the cost-effectiveness of rituximab versus the mPR from the perspective of the National Health Service in the UK over a 1 year, 5 year and lifetime horizon...
March 29, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29617477/-social-practices-in-the-medicalization-and-humanization-of-prenatal-care
#16
Cristine Maria Warmling, Ananyr Porto Fajardo, Dagmar Estermann Meyer, Cristophe Bedos
The study's main objective is to analyze how discourses of medicalization and humanization reconnect in primary healthcare and shape prenatal care for pregnant women provided by family health teams. This was a single and integrated case study with multiple analytical units and a qualitative approach. A total of 17 focus groups were performed, in which 47 health professionals were heard (14 physicians, 19 nurses, and 14 dentists), members of 17 family health teams in 16 municipalities in the South of Brazil...
March 29, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29610028/-factors-affecting-in-hospital-mortality-in-patients-with-sepsis-development-of-a-risk-adjusted-model-based-on-administrative-data-from-german-hospitals
#17
Volker König, Olaf Kolzter, Gerd Albuszies, Frank Thölen
BACKGROUND: Inpatient administrative data from hospitals is already used nationally and internationally in many areas of internal and public quality assurance in healthcare. For sepsis as the principal condition, only a few published approaches are available for Germany. The aim of this investigation is to identify factors influencing hospital mortality by employing appropriate analytical methods in order to improve the internal quality management of sepsis. METHODS: The analysis was based on data from 754,727 DRG cases of the CLINOTEL hospital network charged in 2015...
March 30, 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29607103/unraveling-pbf-effects-beyond-impact-evaluation-results-from-a-qualitative-study-in-cameroon
#18
Manuela De Allegri, Maria Paola Bertone, Shannon McMahon, Idrissou Mounpe Chare, Paul Jacob Robyn
Introduction: Performance-based financing (PBF) has acquired increased prominence as a means of reforming health system purchasing structures in low-income and middle-income countries. A number of impact evaluations have noted that PBF often produces mixed and heterogeneous effects. Still, little systematic effort has been channelled towards understanding what causes such heterogeneity, including looking more closely at implementation processes. Methods: Our qualitative study aimed at closing this gap in knowledge by attempting to unpack the mixed and heterogeneous effects detected by the PBF impact evaluation in Cameroon to inform further implementation as the country scales up the PBF approach...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29606611/validation-of-king-s-transaction-process-for-healthcare-provider-patient-communication-in-pharmaceutical-context-one-cross-sectional-study
#19
Dan Wang, Chenxi Liu, Zinan Zhang, Liping Ye, Xinping Zhang
BACKGROUND: With the impressive advantages of patient-pharmacist communication being advocated and poor pharmacist-patient communication in different settings, it is of great significance and urgency to explore the mechanism of the pharmacist-patient communicative relationship. The King's theory of goal attainment is proposed as one of the most promising models to be applied, because it takes into consideration both improving the patient-pharmacist relationship and attaining patients' health outcomes...
March 27, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29606124/transferring-skills-in-quality-collaboratives-focused-on-improving-patient-logistics
#20
Anne Marie Weggelaar-Jansen, Jeroen van Wijngaarden
BACKGROUND: A quality improvement collaborative, often used by the Institute for Healthcare Improvement, is used to educate healthcare professionals and improve healthcare at the same time. However, no prior research has been done on the knowledge and skills healthcare professionals need to achieve improvements or the extent to which quality improvement collaboratives help enhance both knowledge and skills. Our research focused on quality improvement collaboratives aiming to improve patient logistics and tried to identify which knowledge and skills are required and to what extent these were enhanced during the QIC...
April 2, 2018: BMC Health Services Research
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