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https://www.readbyqxmd.com/read/28534685/biotin-interference-with-routine-clinical-immunoassays-understand-the-causes-and-mitigate-the-risks
#1
Shanika Samarasinghe, Farah Meah, Vinita Singh, Arshi Basit, Nicholas Emanuele, Mary Ann Emanuele, Alaleh Mazhari, Earle W Holmes
OBJECTIVES: The objectives of this report are to review the mechanisms of biotin interference with streptavidin/biotin-based immunoassays, identify automated immunoassay systems vulnerable to biotin interference, describe how to estimate and minimize the risk of biotin interference in vulnerable assays, and review the literature pertaining to biotin interference in endocrine function tests. METHODS: The data in the manufacturer's "Instructions for Use" for each of the methods utilized by seven immunoassay system were evaluated...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28531992/boronate-functionalized-hydrogel-as-a-novel-biosensing-interface-for-the-glycated-hemoglobin-a1c-hba1c-based-on-the-competitive-binding-with-signaling-glycoprotein
#2
Yong Duk Han, Ka Ram Kim, Yoo Min Park, Seung Yeon Song, Yong Ju Yang, Kangsun Lee, Yunhee Ku, Hyun C Yoon
According to recent increases in public healthcare costs associated with diabetes mellitus, the development of new glycemic monitoring techniques based on the biosensing of glycated hemoglobin A1c (HbA1c), a promising long-term glycemic biomarker, has become a major challenge. In the development of HbA1c biosensors for point-of-care applications, the selection of an effective biorecognition layer that provides a high reaction yield and specificity toward HbA1c is regarded as the most significant issue. To address this, we developed a novel HbA1c biosensing interfacial material by the integration of boronate hydrogel with glass fiber membrane...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530515/cost-effectiveness-of-strategies-to-increase-cervical-screening-uptake-at-first-invitation-strategic
#3
Apostolos Tsiachristas, Matthew Gittins, Henry Kitchener, Alastair Gray
Objective To assess the cost-effectiveness of strategies to increase cervical cancer screening uptake at first invitation (STRATEGIC trial). Methods We performed an economic analysis alongside the STRATEGIC trial, comparing each of seven novel interventions for improving cervical screening uptake with control general practices in Greater Manchester and Grampian (United Kingdom). A template was developed to measure the intervention costs. Trial estimates of screening uptake were combined with data from the literature to estimate healthcare costs of each intervention...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28528557/-naming-and-framing-the-impact-of-labeling-on-health-state-values-for-multiple-sclerosis
#4
Colin Green, Elizabeth Goodwin, Annie Hawton
INTRODUCTION: Health state valuation is a key input in many economic evaluations that inform resource allocation across competing healthcare interventions. Empirical evidence has shown that, in preference elicitation surveys, respondents may value a health state differently if they are aware of the condition causing it ('labeling effects'). This study investigates the impact of including a multiple sclerosis (MS) label for valuation of MS health states. METHODS: Health state values for MS were elicited using two internet-based surveys in representative samples of the UK population ( n = 1702; n = 1788)...
May 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28520656/the-power-of-a-parent-s-touch-evaluation-of-reach-and-impact-of-a-targeted-evidence-based-youtube-video
#5
Marsha Campbell-Yeo, Justine Dol, Timothy Disher, Britney Benoit, Christine T Chambers, Kaitlyn Sheffield, Talia Boates, Denise Harrison, Brenda Hewitt, Krista Jangaard, Jennifer Stinson, Anna Taddio, Jennifer A Parker, Kim Caddell
Despite strong evidence that skin-to-skin contact and breast-feeding are effective pain-relieving interventions for infants undergoing painful procedures, they remain underutilized in clinical practice. Given the important contribution of parents, there is a need to find innovative ways to assist parents to become actively involved in their infant's care. We developed a YouTube video to disseminate evidence-based information on the effectiveness of skin-to-skin contact and breast-feeding for infant pain management...
May 17, 2017: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/28515573/problematisations-of-complexity-on-the-notion-and-production-of-diverse-complexities-in-healthcare-interventions-and-evaluations
#6
Tineke Broer, Roland Bal, Martyn Pickersgill
Within the literature on the evaluation of health (policy) interventions, complexity is a much-debated issue. In particular, many claim that so-called 'complex interventions' pose different challenges to evaluation studies than apparently 'simple interventions' do. Distinct ways of doing evaluation entail particular ontologies and epistemologies of complexity. They differ in terms of whether they define complexity as a quantitative trait of interventions, whether they see evaluation as part of or outside the intervention, and whether complexity can be regarded as an emergent property of the intervention and its evaluation...
April 3, 2017: Science As Culture
https://www.readbyqxmd.com/read/28511451/attitudes-of-mashhad-public-hospital-s-nurses-and-midwives-toward-the-causes-and-rates-of-medical-errors-reporting
#7
Sedigheh Sedigh Mobarakabadi, Hosein Ebrahimipour, Ali Vafaie Najar, Roksana Janghorban, Fatemeh Azarkish
INTRODUCTION: Patient's safety is one of the main objective in healthcare services; however medical errors are a prevalent potential occurrence for the patients in treatment systems. Medical errors lead to an increase in mortality rate of the patients and challenges such as prolonging of the inpatient period in the hospitals and increased cost. Controlling the medical errors is very important, because these errors besides being costly, threaten the patient's safety. AIM: To evaluate the attitudes of nurses and midwives toward the causes and rates of medical errors reporting...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509578/the-burden-of-hepatorenal-syndrome-among-commercially-insured-and-medicare-patients-in-the-united-states
#8
J Bradford Rice, Alan G White, Philip Galebach, Kevin M Korenblat, Aneesha Wagh, Belinda Lovelace, George J Wan, Khurram Jamil
BACKGROUND: This study evaluated the characteristics healthcare resource utilization (HCRU), and costs, from the payer perspective, of hepatorenal syndrome (HRS) patients covered by commercial and Medicare insurance. Mortality was assessed as a secondary outcome. METHODS: Patients were identified from claims databases of commercially-insured (OptumHealth Care Solutions, Inc.) in 1998-2014 and Medicare beneficiaries in 2009-2013 (5% Standard Analytic Files). At the time of their first inpatient admission ("index date") with an HRS diagnosis (ICD-9 code 572...
May 16, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28507610/improving-patient-safety-in-hospitals-through-usage-of-cloud-supported-video-surveillance
#9
Predrag Dašić, Jovan Dašić, Bojan Crvenković
BACKGROUND: Patient safety in hospitals is of equal importance as providing treatments and urgent healthcare. With the development of Cloud technologies and Big Data analytics, it is possible to employ VSaaS technology virtually anywhere, for any given security purpose. AIM: For the listed benefits, in this paper, we give an overview of the existing cloud surveillance technologies which can be implemented for improving patient safety. MATERIAL AND METHODS: Modern VSaaS systems provide higher elasticity and project scalability in dealing with real-time information processing...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28501754/expectant-futures-and-an-early-diagnosis-of-alzheimer-s-disease-knowing-and-its-consequences
#10
Julia Swallow
Efforts to diagnose Alzheimer's disease (AD) at earlier stages as a means to managing the risks of an ageing population, dominate scientific research and healthcare policy in the UK. It is anticipated that early diagnosis will maximise treatment options and enable patients to 'prepare for their future' in terms of care. Drawing on qualitative data gathered across an out-patient memory service and in-patient hospital in the UK, the purpose of this paper is to examine the ways in which the hopeful promissory claims of early diagnosis as it maintains the dominant biomedical model for managing AD, are negotiated by healthcare practitioners...
May 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28501533/promising-modalities-to-identify-and-monitor-eosinophilic-esophagitis
#11
Girish Hiremath, Sandeep K Gupta
Eosinophilic esophagitis (EoE) is an allergen-mediated condition characterized by symptoms of esophageal dysfunction and histological evidence of intense eosinophilic inflammation involving the esophagus in absence of overlapping conditions such as gastroesophageal reflux disease. Since the initial description as a distinct entity about two decades ago, there has been a remarkable rise in the recognition of this clinico-pathologic entity. Current approach to diagnose and monitor EoE requires repeated esophagogastroduodenoscopies (EGDs), with associated sedation/anesthesia, to visualize mucosal abnormalities, and to obtain multiple biopsies for histologic assessment and to evaluate treatment response...
May 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28501464/the-connection-between-nursing-diagnosis-and-the-use-of-healthcare-resources
#12
María Consuelo Company-Sancho, Marcos Estupiñán-Ramírez, Hilda Sánchez-Janáriz, Rita Tristancho-Ajamil
AIM: The health service invests up to 75% of its resources on chronic care where the focus should be on caring rather than curing. Nursing staff focuses their work on such care. Care requires being redorded in health histories through the standardized languages. These records enable useful analyses to organisational and healthcare decision-making. Our proposal is to know the association of between nursing diagnosis and a higher total expenditure on health. METHOD: An observational cross-sectional analytical study was performed based on data from electronic health records in Primary Care (Drago-AP), hospital discharges (CMBD-AH) and prescriptions (REC-SCS) of patients over 50 from 2012-2013 in the Canary Islands...
May 10, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28499195/using-the-rubik-s-cube-to-directly-produce-paper-analytical-devices-for-quantitative-point-of-care-aptamer-based-assays
#13
Haiyan Fu, Juanhua Yang, Lin Guo, Jinfang Nie, Qiaobo Yin, Lang Zhang, Yun Zhang
In this article, we describe a facile method named as Rubik's Cube stamping (RCS) for equipment-free fabrication of microfluidic paper-based analytical devices (μPADs). RCS is inspired by the worldwide ubiquitous RC toy and requires no specialized electric equipment other than a classical six-faced RC that is assembled with home-made small iron components. It can pattern various rosin microstructures in paper simply by either using different functional faces of the modified RC or applying its internal pivot mechanism to adjust the components' patterning forms on one functional face...
May 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28498094/predictors-of-all-cause-30-day-readmission-among-medicare-patients-with-type-2-diabetes
#14
Jenna Collins, Ibrahim M Abbass, Raymond Harvey, Brandon Suehs, Claudia Uribe, Jonathan Bouchard, Todd Prewitt, Tony DeLuzio, Elsie Allen
OBJECTIVE: Readmission is costly among patients with type 2 diabetes (T2DM) in Medicare Advantage Prescription Drug Plans; identifying high-risk patients is necessary for targeting reduction programs. The objective of this study was to develop a claims-based algorithm to predict all-cause 30-day readmission among patients with T2DM. METHODS: This study used administrative data from 1/1/2012 through 1/31/2014. The cohort included hospitalized T2DM patients, aged 18-90 with ≥12 months' continuous-enrollment before an unplanned hospital admission and ≥1 month of enrollment post-discharge, excluding patients in long-term care >30 days pre-index...
May 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28498053/autism-behavior-inventory-a-novel-tool-for-assessing-core-and-associated-symptoms-of-autism-spectrum-disorder
#15
Abi Bangerter, Seth Ness, Michael G Aman, Anna J Esbensen, Matthew S Goodwin, Geraldine Dawson, Robert Hendren, Bennett Leventhal, Anzalee Khan, Mark Opler, Adrianne Harris, Gahan Pandina
OBJECTIVE: Autism Behavior Inventory (ABI) is a new measure for assessing changes in core and associated symptoms of autism spectrum disorder (ASD) in participants (ages: 3 years-adulthood) diagnosed with ASD. It is a web-based tool with five domains (two ASD core domains: social communication, restrictive and repetitive behaviors; three associated domains: mental health, self-regulation, and challenging behavior). This study describes design, development, and initial psychometric properties of the ABI...
May 12, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28497805/the-changing-prevalence-and-incidence-of-dementia-over-time-current-evidence
#16
REVIEW
Yu-Tzu Wu, Alexa S Beiser, Monique M B Breteler, Laura Fratiglioni, Catherine Helmer, Hugh C Hendrie, Hiroyuki Honda, M Arfan Ikram, Kenneth M Langa, Antonio Lobo, Fiona E Matthews, Tomoyuki Ohara, Karine Pérès, Chengxuan Qiu, Sudha Seshadri, Britt-Marie Sjölund, Ingmar Skoog, Carol Brayne
Dementia is an increasing focus for policymakers, civil organizations and multidisciplinary researchers. The most recent descriptive epidemiological research into dementia is enabling investigation into how the prevalence and incidence are changing over time. To establish clear trends, such comparisons need to be founded on population-based studies that use similar diagnostic and research methods consistently over time. This narrative Review synthesizes the findings from 14 studies that investigated trends in dementia prevalence (nine studies) and incidence (five studies) from Sweden, Spain, the UK, the Netherlands, France, the USA, Japan and Nigeria...
May 12, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28495005/developing-a-ubiquitous-health-management-system-with-healthy-diet-control-for-metabolic-syndrome-healthcare-in-taiwan
#17
Yao-Chiang Kan, Kai-Hong Chen, Hsueh-Chun Lin
BACKGROUND AND OBJECTIVE: Self-management in healthcare can allow patients managing their health data anytime and everywhere for prevention of chronic diseases. This study established a prototype of ubiquitous health management system (UHMS) with healthy diet control (HDC) for people who need services of metabolic syndrome healthcare in Taiwan. METHODS: System infrastructure comprises of three portals and a database tier with mutually supportive components to achieve functionality of diet diaries, nutrition guides, and health risk assessments for self-health management...
June 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28480160/public-use-of-electronic-personal-health-information-measuring-progress-of-the-healthy-people-2020-objectives
#18
Alexandra J Greenberg, Katrina J Serrano, Chan L Thai, Kelly D Blake, Richard P Moser, Bradford W Hesse, David K Ahern
Use of the internet for seeking and managing health information in the U.S., Europe, and emerging and developing nations is growing. Recent global trends indicate more interactive uses of the internet including online communication with providers. In the U.S., The Healthy People 2020 (HP2020) initiative was created by the Department of Health and Human Services to provide 10-year goals for improving the health of American citizens. Two goals of HP2020 were to increase the proportion of individuals who use the Internet to keep track of their personal health information (PHI) online and to increase the proportion of individuals who use the internet to communicate with their healthcare provider...
March 2017: Health Policy and Technology
https://www.readbyqxmd.com/read/28476479/the-cost-effectiveness-of-a-mechanical-compression-device-in-out-of-hospital-cardiac-arrest
#19
Joachim Marti, Claire Hulme, Zenia Ferreira, Silviya Nikolova, Ranjit Lall, Charlotte Kaye, Michael Smyth, Charlotte Kelly, Tom Quinn, Simon Gates, Charles D Deakin, Gavin D Perkins
AIM: To assess the cost-effectiveness of LUCAS-2, a mechanical device for cardiopulmonary resuscitation (CPR) as compared to manual chest compressions in adults with non-traumatic, out-of-hospital cardiac arrest. METHODS: We analysed patient-level data from a large, pragmatic, multi-centre trial linked to administrative secondary care data from the Hospital Episode Statistics (HES) to measure healthcare resource use, costs and outcomes in both arms. A within-trial analysis using quality adjusted life years derived from the EQ-5D-3L was conducted at 12-month follow-up and results were extrapolated to the lifetime horizon using a decision-analytic model...
May 2, 2017: Resuscitation
https://www.readbyqxmd.com/read/28473507/cost-effectiveness-of-anatomical-and-functional-test-strategies-for-stable-chest-pain-public-health-perspective-from-a-middle-income-country
#20
Eduardo G Bertoldi, Steffen F Stella, Luis Eduardo P Rohde, Carisi A Polanczyk
OBJECTIVES: The aim of this research is to evaluate the relative cost-effectiveness of functional and anatomical strategies for diagnosing stable coronary artery disease (CAD), using exercise (Ex)-ECG, stress echocardiogram (ECHO), single-photon emission CT (SPECT), coronary CT angiography (CTA) or stress cardiacmagnetic resonance (C-MRI). SETTING: Decision-analytical model, comparing strategies of sequential tests for evaluating patients with possible stable angina in low, intermediate and high pretest probability of CAD, from the perspective of a developing nation's public healthcare system...
May 4, 2017: BMJ Open
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