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https://www.readbyqxmd.com/read/27896765/blood-bio-sampling-procedures-for-multiplex-biomarkers-studies
#1
Paul C Guest, Hassan Rahmoune
A major challenge in single or panel of biomarker discovery and validation is the inherent biological complexity underlying disease heterogeneity and inconsistent responses to treatment. Moreover, the lack of standardization in the sampling, processing, and storage of biological fluids such as plasma and serum disrupts the discovery and validation of blood-based biomarker tests in preclinical and clinical settings. This chapter presents a reproducible sample collection and handling procedure that aims to enhance analyte stability and ensure compatibility with the corresponding multiplex biomarker profiling platforms...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27890783/the-proline-glycine-rich-region-of-the-biofilm-adhesion-protein-aap-forms-an-extended-stalk-that-resists-compaction
#2
Alexander E Yarawsky, Lance R English, Steven T Whitten, Andrew B Herr
Staphylococcus epidermidis is one of the primary bacterial species responsible for healthcare-associated infections. The most significant virulence factor for S. epidermidis is its ability to form a biofilm, which renders the bacteria highly resistant to host immune responses and antibiotic action. Intercellular adhesion within the biofilm is mediated by the accumulation-associated protein (Aap), a cell wall-anchored protein that self-assembles in a zinc-dependent manner. The C-terminal portion of Aap contains a proline/glycine-rich, 135 amino acid-long region that has not yet been characterized...
November 24, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27884162/-the-stars-seem-aligned-a-qualitative-study-to-understand-the-effects-of-context-on-scale-up-of-maternal-and-newborn-health-innovations-in-ethiopia-india-and-nigeria
#3
Neil Spicer, Della Berhanu, Dipankar Bhattacharya, Ritgak Dimka Tilley-Gyado, Meenakshi Gautham, Joanna Schellenberg, Addis Tamire-Woldemariam, Nasir Umar, Deepthi Wickremasinghe
BACKGROUND: Donors commonly fund innovative interventions to improve health in the hope that governments of low and middle-income countries will scale-up those that are shown to be effective. Yet innovations can be slow to be adopted by country governments and implemented at scale. Our study explores this problem by identifying key contextual factors influencing scale-up of maternal and newborn health innovations in three low-income settings: Ethiopia, the six states of northeast Nigeria and Uttar Pradesh state in India...
November 25, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27875247/comorbidity-prevalence-healthcare-utilization-and-expenditures-of-medicaid-enrolled-adults-with-autism-spectrum-disorders
#4
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi
A retrospective data analysis using 2000-2008 three state Medicaid Analytic eXtract was conducted to examine the prevalence and association of comorbidities (psychiatric and non-psychiatric) with healthcare utilization and expenditures of fee-for-service enrolled adults (22-64 years) with and without autism spectrum disorders (International Classification of Diseases, Ninth Revision-clinical modification code: 299.xx). Autism spectrum disorder cases were 1:3 matched to no autism spectrum disorder controls by age, gender, and race using propensity scores...
October 20, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27874982/rethinking-presence-a-grounded-theory-of-nurses-and-teleconsultation
#5
David Barrett
AIMS AND OBJECTIVES: The study aimed to develop a theory that offered an evidence-based insight into the use of teleconsultation by nurses. BACKGROUND: Teleconsultation is the use of video to facilitate real-time, remote interaction between healthcare practitioners and patients. Though its popularity is growing, there is little understanding of how teleconsultation impacts on the role of nurses. METHOD: The study adopted a constructivist grounded theory method, supplemented by the use of Straussian analytical approaches...
November 22, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27873357/use-of-big-data-for-drug-development-and-for-public-and-personal-health-and-care
#6
Lada Leyens, Matthias Reumann, Nuria Malats, Angela Brand
The use of data analytics across the entire healthcare value chain, from drug discovery and development through epidemiology to informed clinical decision for patients or policy making for public health, has seen an explosion in the recent years. The increase in quantity and variety of data available together with the improvement of storing capabilities and analytical tools offer numerous possibilities to all stakeholders (manufacturers, regulators, payers, healthcare providers, decision makers, researchers) but most importantly, it has the potential to improve general health outcomes if we learn how to exploit it in the right way...
November 21, 2016: Genetic Epidemiology
https://www.readbyqxmd.com/read/27873285/prescription-drug-use-and-polypharmacy-among-medicaid-enrolled-adults-with-autism-a-retrospective-cross-sectional-analysis
#7
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi, Claire StPeter, Susannah Poe, Nilanjana Dwibedi, Mayank Ajmera
BACKGROUND: A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults. OBJECTIVE: The aim of this study was to identify and compare the types of prescription drug use, rates of polypharmacy, and characteristics associated with polypharmacy among adults with and without ASD in a retrospective cross-sectional analysis of a three-state Medicaid Analytic eXtract database (2000-2008)...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27869580/qualitative-analysis-of-multi-disciplinary-round-table-discussions-on-the-acceleration-of-benefits-and-data-analytics-through-hospital-electronic-prescribing-eprescribing-systems
#8
Kathrin Cresswell, Jamie Coleman, Pam Smith, Charles Swainson, Ann Slee, Aziz Sheikh
BACKGROUND: Electronic systems that facilitate prescribing, administration and dispensing of medicines (ePrescribing systems) are at the heart of international efforts to improve the safety, quality and efficiency of medicine management. Considering the initial costs of procuring and maintaining ePrescribing systems, there is a need to better understand how to accelerate and maximise the financial benefits associated with these systems. OBJECTIVES: We sought to investigate how different sectors are approaching the realisation of returns on investment from ePrescribing systems in U...
July 4, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/27864208/payer-view-of-personalized-medicine
#9
Edmund J Pezalla
PURPOSE: The process and methods used by payers when evaluating coverage of personalized medicine testing are described. SUMMARY: Personalized medicine encompasses a number of diagnostic tools that measure drug metabolism, genetic risk for disease development, and tumor type or markers that can guide oncology treatments. However, whole genome testing, tumor marker testing, and testing for drug metabolism are additional costs to the healthcare system. In order to justify these costs, payers and health technology assessment bodies must evaluate the individual tests or groups of tests on their own merits...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27862002/distributed-data-networks-a-blueprint-for-big-data-sharing-and-healthcare-analytics
#10
Jennifer R Popovic
This paper defines the attributes of distributed data networks and outlines the data and analytic infrastructure needed to build and maintain a successful network. We use examples from one successful implementation of a large-scale, multisite, healthcare-related distributed data network, the U.S. Food and Drug Administration-sponsored Sentinel Initiative. Analytic infrastructure-development concepts are discussed from the perspective of promoting six pillars of analytic infrastructure: consistency, reusability, flexibility, scalability, transparency, and reproducibility...
November 18, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27849373/adaptation-and-implementation-of-an-intervention-to-reduce-hiv-related-stigma-among-healthcare-workers-in-the-united-states-piloting-of-the-fresh-workshop
#11
D Scott Batey, Samantha Whitfield, Mazheruddin Mulla, Kristi L Stringer, Modupeoluwa Durojaiye, Lisa McCormick, Bulent Turan, Laura Nyblade, Mirjam-Colette Kempf, Janet M Turan
HIV-related stigma has been shown to have profound effects on people living with HIV (PLWH). When stigma is experienced in a healthcare setting, negative health outcomes are exacerbated. We sought to assess the feasibility and acceptability of a healthcare setting stigma-reduction intervention, the Finding Respect and Ending Stigma around HIV (FRESH) Workshop, in the United States. This intervention, adapted from a similar strategy implemented in Africa, brought together healthcare workers (HW) and PLWH to address HIV-related stigma...
November 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27843420/historical-data-analysis-of-hospital-discharges-related-to-the-amerithrax-attack-in-florida
#12
Lauralyn K Burke, C Perry Brown, Tammie M Johnson
Interrupted time-series analysis (ITSA) can be used to identify, quantify, and evaluate the magnitude and direction of an event on the basis of time-series data. This study evaluates the impact of the bioterrorist anthrax attacks ("Amerithrax") on hospital inpatient discharges in the metropolitan statistical area of Palm Beach, Broward, and Miami-Dade counties in the fourth quarter of 2001. Three statistical methods-standardized incidence ratio (SIR), segmented regression, and an autoregressive integrated moving average (ARIMA)-were used to determine whether Amerithrax influenced inpatient utilization...
2016: Perspectives in Health Information Management
https://www.readbyqxmd.com/read/27836506/evaluating-community-health-centers-adoption-of-a-new-global-capitation-payment-echange-study-protocol
#13
H Angier, J P O'Malley, M Marino, K J McConnell, E Cottrell, R L Jacob, S Likumahuwa-Ackman, J Heintzman, N Huguet, S R Bailey, J E DeVoe
Primary care patient-centered medical homes (PCMHs) are an effective healthcare delivery model. Evidence regarding the most effective payment models for increased coordination efforts is sparse. This protocol paper describes the evaluation of an Alternative Payment Methodology (APM) implemented in a subset of Oregon community health centers (CHCs), using a prospective matched observational design. The APM is a primary care payment reform intervention that changed Oregon's Medicaid payment for several CHCs from fee-for-service reimbursement to a per-member-per-month capitated payment...
November 9, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27830255/aspiring-to-unintended-consequences-of-natural-language-processing-a-review-of-recent-developments-in-clinical-and-consumer-generated-text-processing
#14
D Demner-Fushman, N Elhadad
OBJECTIVES: This paper reviews work over the past two years in Natural Language Processing (NLP) applied to clinical and consumer-generated texts. METHODS: We included any application or methodological publication that leverages text to facilitate healthcare and address the health-related needs of consumers and populations. RESULTS: Many important developments in clinical text processing, both foundational and task-oriented, were addressed in community- wide evaluations and discussed in corresponding special issues that are referenced in this review...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27829413/feasibility-of-digital-footprint-data-for-health-analytics-and-services-an-explorative-pilot-study
#15
Marja Harjumaa, Saila Saraniemi, Saara Pekkarinen, Minna Lappi, Heidi Similä, Minna Isomursu
BACKGROUND: As a result of digitalization, data is available about almost every aspect of our lives. Personal data collected by individuals themselves or stored by organizations interacting with people is known as a digital footprint. The purpose of this study was to identify prerequisites for collecting and using digital data that could be valuable for health data analytics and new health services. METHODS: Researchers and their contacts involved in a nationwide research project focusing on digital health in Finland were asked to participate in a pilot study on collecting their own personal data from various organizations of their own choice, such as retail chains, banks, insurance companies, and healthcare providers...
November 9, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27828678/health-and-innovation-economic-dynamics-and-welfare-state-in-brazil
#16
Carlos Augusto Grabois Gadelha, Patrícia Seixas da Costa Braga
The effective enforcement of the access to healthcare as fundamental right requires an important theoretical and political effort at linking the often contradictory economic and social dimensions of development. This study suggests the need for a systemic view of policies related to the industrial base and innovation in health and the construction of the Brazilian Unified National Health System (SUS). The authors investigate the relations between health, innovation, and development, seeking to show and update the political, economic, and social determinants of the recent Brazilian experience with the Health Economic-Industrial Complex (HEIC)...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27828580/an-evaluation-of-elderly-people-s-understanding-of-pharmacotherapy-among-those-treated-in-the-primary-healthcare-system-in-belo-horizonte-brazil
#17
Isabela Vaz Leite Pinto, Adriano Max Moreira Reis, Celline Cardoso Almeida-Brasil, Micheline Rosa da Silveira, Marina Guimarães Lima, Maria das Graças Braga Ceccato
There are a greater number of elderly people with diseases which has led to a greater use in medication and complexity in pharmacotherapy. The aim of this study was to understand the level of understanding on pharmacotherapy amongst the elderly and associated factors. An analytical transversal study was carried out in the Primary Health Care Units. Sociodemographic, clinical, and functional characteristics relative to the use of medication were explored. The level of understanding was obtained after a concordance analysis had been done based on the responses from the interviewees and the information on the medical prescriptions such as: name of medication, dosage, frequency, indication, precautions and side effects...
November 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27827859/precision-health-economics-and-outcomes-research-to-support-precision-medicine-big-data-meets-patient-heterogeneity-on-the-road-to-value
#18
Yixi Chen, Gregory F Guzauskas, Chengming Gu, Bruce C M Wang, Wesley E Furnback, Guotong Xie, Peng Dong, Louis P Garrison
The "big data" era represents an exciting opportunity to utilize powerful new sources of information to reduce clinical and health economic uncertainty on an individual patient level. In turn, health economic outcomes research (HEOR) practices will need to evolve to accommodate individual patient-level HEOR analyses. We propose the concept of "precision HEOR", which utilizes a combination of costs and outcomes derived from big data to inform healthcare decision-making that is tailored to highly specific patient clusters or individuals...
November 2, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/27825798/prognostics-of-surgical-site-infections-using-dynamic-health-data
#19
Chuyang Ke, Yan Jin, Heather Evans, Bill Lober, Xiaoning Qian, Ji Liu, Shuai Huang
Surgical Site Infection (SSI) is a national priority in healthcare research. Much research attention has been attracted to develop better SSI risk prediction models. However, most of the existing SSI risk prediction models are built on static risk factors such as comorbidities and operative factors. In this paper, we investigate the use of the dynamic wound data for SSI risk prediction. There have been emerging mobile health (mHealth) tools that can closely monitor the patients and generate continuous measurements of many wound-related variables and other evolving clinical variables...
November 4, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27806581/analytically-based-photon-scatter-modeling-for-a-multipinhole-cardiac-spect-camera
#20
Amir Pourmoghaddas, R Glenn Wells
PURPOSE: Dedicated cardiac SPECT scanners have improved performance over standard gamma cameras allowing reductions in acquisition times and/or injected activity. One approach to improving performance has been to use pinhole collimators, but this can cause position-dependent variations in attenuation, sensitivity, and spatial resolution. CT attenuation correction (AC) and an accurate system model can compensate for many of these effects; however, scatter correction (SC) remains an outstanding issue...
November 2016: Medical Physics
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