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https://www.readbyqxmd.com/read/29220878/a-qualitative-study-of-the-experience-of-lower-extremity-wounds-and-amputations-among-people-with-diabetes-in-philadelphia
#1
Frances K Barg, Peter F Cronholm, Ebony E Easley, Trocon Davis, Michelle Hampton, D Scot Malay, Cornelius Donohue, Jinsup Song, Stephen R Thom, David J Margolis
The purpose of this study was to explore perceptions among people with type 2 diabetes about foot ulcers and lower extremity amputations. This was a qualitative observational study utilizing open-ended, semistructured interviews of 39 people with diabetes who were purposively selected because they had either a foot ulcer (n = 19) or a lower extremity amputation (n = 20). Interviews were audio-recorded, deidentified, and entered into NVivo 10.0 for coding and analysis. Our integrated analytic approach combined inductively and deductively derived codes that were applied to all transcripts...
December 8, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29220802/conducting-polymer-based-electrochemical-biosensors-for-neurotransmitters-a-review
#2
REVIEW
Jong-Min Moon, Neeta Thapliyal, Khalil Khadim Hussain, Rajendra N Goyal, Yoon-Bo Shim
Neurotransmitters are important biochemical molecules that control behavioral and physiological functions in central and peripheral nervous system. Therefore, the analysis of neurotransmitters in biological samples has a great clinical and pharmaceutical importance. To date, various methods have been developed for their assay. Of the various methods, the electrochemical sensors demonstrated the potential of being robust, selective, sensitive, and real time measurements. Recently, conducting polymers (CPs) and their composites have been widely employed in the fabrication of various electrochemical sensors for the determination of neurotransmitters...
December 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29220199/risk-factors-for-gaps-in-care-during-transfer-from-pediatric-to-adult-cystic-fibrosis-programs-in-the-united-states
#3
Gregory S Sawicki, Joshua Ostrenga, Kristofer Petren, Aliza K Fink, Emma D'Agostino, Camila Strassle, Michael S Schechter, Margaret Rosenfeld
RATIONALE: With improved survival into adulthood, the number of dedicated adult cystic fibrosis (CF) care programs has expanded in the US over the past decade. Transfer from pediatric to adult CF programs represents a potential time for lapses in recommended healthcare. OBJECTIVES: To describe variability in transfer between pediatric and adult CF care programs and to identify factors associated with prolonged gaps in care. METHODS: Using the US CF Foundation Patient Registry (CFFPR), we identified individuals with CF who transferred care from a pediatric to adult CF care program during 2007-2013...
December 8, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29214005/semantics-powered-healthcare-engineering-and-data-analytics
#4
EDITORIAL
Zhe He, Cui Tao, Jiang Bian, Michel Dumontier, William R Hogan
No abstract text is available yet for this article.
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29212678/the-myths-of-big-data-in-health-care
#5
REVIEW
D J Jacofsky
'Big data' is a term for data sets that are so large or complex that traditional data processing applications are inadequate. Billions of dollars have been spent on attempts to build predictive tools from large sets of poorly controlled healthcare metadata. Companies often sell reports at a physician or facility level based on various flawed data sources, and comparative websites of 'publicly reported data' purport to educate the public. Physicians should be aware of concerns and pitfalls seen in such data definitions, data clarity, data relevance, data sources and data cleaning when evaluating analytic reports from metadata in health care...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29206963/occupational-exposure-to-alcohol-based-hand-sanitizers-the-diagnostic-role-of-alcohol-biomarkers-in-hair
#6
A Salomone, A Bozzo, D Di Corcia, E Gerace, M Vincenti
Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) in hair are effective direct biomarkers of ethanol ingestion, whose analytical determination can be used to discriminate between chronic and occasional ethanol intake. Ethanol is a compound widely used in some workplaces (e.g., clinics, hospitals) and is present in considerable amounts in mouthwash for oral cleaning, medications, cosmetic products, hydro-alcoholic disinfectants and antiseptics for hands. This study examined the ethyl alcohol exposure derived from hand disinfectants (in gel form) by simulating the typical occupational situation of medical-health workers (healthcare workers, nurses, surgeons, etc...
December 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29205294/wearable-devices-in-clinical-trials-hype-and-hypothesis
#7
Elena S Izmailova, John A Wagner, Eric D Perakslis
The development of innovative wearable technologies has raised great interest in new means of data collection in healthcare and biopharmaceutical research and development. Multiple applications for wearables have been identified in a number of therapeutic areas; however, researchers face many challenges in the clinic, including scientific methodology as well as regulatory, legal, and operational hurdles. To facilitate further evaluation and adoption of these technologies, we highlight methodological and logistical considerations for implementation in clinical trials, including key elements of analytical and clinical validation in the specific context of use (COU)...
December 5, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29202578/label-free-detection-of-microvesicles-and-proteins-by-the-bundling-of-gliding-microtubules
#8
Samata Chaudhuri, Till Korten, Slobodanka Korten, Gloria Milani, Tobia Lana, Geertruy Te Kronnie, Stefan Diez
Development of miniaturized devices for the rapid and sensitive detection of analyte is crucial for various applications across healthcare, pharmaceutical, environmental, and other industries. Here, we report on the detection of unlabeled analyte by using fluorescently-labeled, antibody-conjugated microtubules in a kinesin-1 gliding motility assay. The detection principle is based on the formation of fluorescent supramolecular assemblies of microtubule bundles and spools in the presence of multivalent analytes...
December 5, 2017: Nano Letters
https://www.readbyqxmd.com/read/29202321/quantitative-analysis-of-breast-cancer-diagnosis-using-a-probabilistic-modelling-approach
#9
Shuo Liu, Jinshu Zeng, Huizhou Gong, Hongqin Yang, Jia Zhai, Yi Cao, Junxiu Liu, Yuling Luo, Yuhua Li, Liam Maguire, Xuemei Ding
BACKGROUND: Breast cancer is the most prevalent cancer in women in most countries of the world. Many computer-aided diagnostic methods have been proposed, but there are few studies on quantitative discovery of probabilistic dependencies among breast cancer data features and identification of the contribution of each feature to breast cancer diagnosis. METHODS: This study aims to fill this void by utilizing a Bayesian network (BN) modelling approach. A K2 learning algorithm and statistical computation methods are used to construct BN structure and assess the obtained BN model...
November 21, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29201863/predictive-assessment-of-cancer-center-catchment-area-from-electronic-health-records
#10
Luca Salmasi, Enrico Capobianco
Healthcare facilities (HF) may identify catchment areas (CA) by selecting criteria that depend on various factors. These refer to hospital activities, geographical definition, patient covariates, and more. The analyses that were traditionally pursued have a limiting factor in the consideration of only static conditions. Instead, some of the CA determinants involve influences occurring at both temporal and spatial scales. The study of CA in the cancer context means choosing between HF, usually divided into general hospitals versus oncological centers (OCs)...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29193893/sex-differences-in-healthcare-utilization-end-stage-renal-disease-and-mortality-among-medicaid-beneficiaries-with-incident-lupus-nephritis
#11
Candace H Feldman, Anna Broder, Hongshu Guan, Jinoos Yazdany, Karen H Costenbader
OBJECTIVE: While systemic lupus erythematosus (SLE) and lupus nephritis (LN) disproportionately affect females, prior studies suggest that males may experience poorer outcomes. We investigated sex differences in healthcare utilization, end-stage renal disease (ESRD) and mortality among patients with LN receiving Medicaid, public insurance for low-income individuals. METHODS: Within Medicaid Analytic eXtract (MAX) from 29 states (2000-2010), we used billing claims to identify individuals 5-65 years with incident LN (PPV 80%)...
November 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29188446/ichrcloud-web-mobile-based-child-health-imprints-for-smart-healthcare
#12
Harpreet Singh, Raghuram Mallaiah, Gautam Yadav, Nitin Verma, Ashu Sawhney, Samir K Brahmachari
Reducing child mortality with quality care is the prime-most concern of all nations. Thus in current IT era, our healthcare industry needs to focus on adapting information technology in healthcare services. Barring few preliminary attempts to digitalize basic hospital administrative and clinical functions, even today in India, child health and vaccination records are still maintained as paper-based records. Also, error in manually plotting the parameters in growth charts results in missed opportunities for early detection of growth disorders in children...
November 29, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29183077/adherence-to-methodological-standards-in-research-using-the-national-inpatient-sample
#13
Rohan Khera, Suveen Angraal, Tyler Couch, John W Welsh, Brahmajee K Nallamothu, Saket Girotra, Paul S Chan, Harlan M Krumholz
Importance: Publicly available data sets hold much potential, but their unique design may require specific analytic approaches. Objective: To determine adherence to appropriate research practices for a frequently used large public database, the National Inpatient Sample (NIS) of the Agency for Healthcare Research and Quality (AHRQ). Design, Setting, and Participants: In this observational study of the 1082 studies published using the NIS from January 2015 through December 2016, a representative sample of 120 studies was systematically evaluated for adherence to practices required by AHRQ for the design and conduct of research using the NIS...
November 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29179290/contextualizing-obesity-and-diabetes-policy-exploring-a-nested-statistical-and-constructivist-approach-at-the-cross-national-and-subnational-government-level-in-the-united-states-and-brazil
#14
Eduardo J Gómez
BACKGROUND: This article conducts a comparative national and subnational government analysis of the political, economic, and ideational constructivist contextual factors facilitating the adoption of obesity and diabetes policy. METHODS: We adopt a nested analytical approach to policy analysis, which combines cross-national statistical analysis with subnational case study comparisons to examine theoretical prepositions and discover alternative contextual factors; this was combined with an ideational constructivist approach to policy-making...
February 27, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29178532/microfluidics-based-point-of-care-diagnostics
#15
REVIEW
Chandra Mouli Pandey, Shine Augustine, Saurabh Kumar, Suveen Kumar, Sharda Nara, Saurabh Srivastava, Bansi D Malhotra
Point-of-care (POC) diagnostic devices have been predicted to provide a boon in health care especially in the diagnosis and detection of diseases. POC devices have been found to have many advantages like a rapid and precise response, portability, low cost, and non-requirement of specialized equipment. The major objective of a POC diagnostic research is to develop a chip-based, self-containing miniaturized device that can be used to examine different analytes in complex samples. Further, the integration of microfluidics (MF) with advanced biosensor technologies is likely to result in improved POC diagnostics...
November 27, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29176907/correction-assessing-the-global-reach-and-value-of-a-provider-facing-healthcare-app-using-large-scale-analytics
#16
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjgh-2017-000299.].
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29164648/a-state-transition-framework-for-patient-level-modeling-of-engagement-and-retention-in-hiv-care-using-longitudinal-cohort-data
#17
Hana Lee, Joseph W Hogan, Becky L Genberg, Xiaotian K Wu, Beverly S Musick, Ann Mwangi, Paula Braitstein
The human immunodeficiency virus (HIV) care cascade is a conceptual model used to outline the benchmarks that reflects effectiveness of HIV care in the whole HIV care continuum. The models can be used to identify barriers contributing to poor outcomes along each benchmark in the cascade such as disengagement from care or death. Recently, the HIV care cascade has been widely applied to monitor progress towards HIV prevention and care goals in an attempt to develop strategies to improve health outcomes along the care continuum...
November 22, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29158194/recent-advances-in-bacteriophage-based-methods-for-bacteria-detection
#18
REVIEW
Łukasz Richter, Marta Janczuk-Richter, Joanna Niedziółka-Jönsson, Jan Paczesny, Robert Hołyst
Fast and reliable bacteria detection is crucial for lowering the socioeconomic burden related to bacterial infections (e.g., in healthcare, industry or security). Bacteriophages (i.e., viruses with bacterial hosts) pose advantages such as great specificity, robustness, toughness and cheap preparation, making them popular biorecognition elements in biosensors and other assays for bacteria detection. There are several possible designs of bacteriophage-based biosensors. Here, we focus on developments based on whole virions as recognition agents...
November 20, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29153947/paper-based-fluorogenic-devices-for-in-vitro-diagnostics
#19
REVIEW
Meirong Wu, Qiongyu Lai, Qiang Ju, Lin Li, Hai-Dong Yu, Wei Huang
In vitro diagnostics (IVD) are essential in healthcare systems for detection of diseases, conditions, or infections. Affordable and sensitive methods remain a challenge in the development of IVD. In this article, we give an overview of paper-based fluorogenic devices, an emerging cost-effective analytical method for IVD applications. The paper-based devices are inexpensive, sensitive, selective, user-friendly and equipment-free. Furthermore, the fluorescent detection on paper-based devices has recently attracted enormous attentions due to its high sensitivity and selectivity...
November 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29153036/waste-management-barriers-in-developing-country-hospitals-case-study-and-ahp-analysis
#20
Diego V de Godoy Delmonico, Hugo H Dos Santos, Marco A P Pinheiro, Rosani de Castro, Regiane M de Souza
Healthcare waste management is an essential field for both researchers and practitioners. Although there have been few studies using statistical methods for its evaluation, it has been the subject of several studies in different contexts. Furthermore, the known precarious practices for waste management in developing countries raise questions about its potential barriers. This study aims to investigate the barriers in healthcare waste management and their relevance. For this purpose, this paper analyses waste management practices in two Brazilian hospitals by using case study and the Analytic Hierarchy Process method...
November 1, 2017: Waste Management & Research
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