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https://www.readbyqxmd.com/read/28726079/bilirubin-enzyme-biosensor-potentiality-and-recent-advances-towards-clinical-bioanalysis
#1
REVIEW
Vinita Hooda, Anjum Gahlaut, Ashish Gothwal, Vikas Hooda
Bilirubin detection plays a major role in healthcare. Its high concentration in human serum is lethal and must be determined accurately. Clinically, it is vital for assessing patients with deleterious health conditions such as jaundice or icterus, hepatitis, mental disorders, cerebral palsy and brain damage especially in the case of neonates. In evaluating the drawbacks regarding the conventional methodology of bilirubin detection, there is need for a superior analytical tool. Bilirubin oxidase (BOx)-based sensors have been designed for the ultrasensitive analysis of bilirubin and quality deliverance of treatment and this review highlights the different mechanisms of bilirubin detection using different modified electrodes...
July 19, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28724399/health-needs-access-to-healthcare-and-perceptions-of-ageing-in-an-urbanizing-community-in-india-a-qualitative-study
#2
Nandita Bhan, Pavitra Madhira, Arundati Muralidharan, Bharati Kulkarni, Gvs Murthy, Sanjay Basu, Sanjay Kinra
BACKGROUND: India's elderly population is rising at an unprecedented rate, with a majority living in rural areas. Health challenges associated with ageing, changing social networks and limited public health infrastructure are issues faced by the elderly and caregivers. We examined perceptions of health needs of the elderly across local stakeholders in an urbanizing rural area. METHODS: The qualitative study was conducted among participants in the Andhra Pradesh Children and Parents Study (APCAPS) site in Rangareddy district, Telangana...
July 19, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28715306/a-data-rich-longitudinal-wellness-study-for-the-digital-age-fixing-a-broken-medical-system-requires-data-about-each-patient
#3
Gustavo Glusman
We live in an age of plentiful information, collected continuously by pervasive gadgetry, distributed through digital and social networks, and mined deeply by ever-more-powerful analytics systems. And yet, one of the things we know the least about is our bodies. When it comes to our own health, we are driving blindly. Modern medicine has clearly been remarkably successful, as evidenced by continually growing life expectancies. For example, the number of people 65 and older in the United States has seen a steady increase over the last century, rising from 3...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28710222/a-developmental-evaluation-to-enhance-stakeholder-engagement-in-a-wide-scale-interactive-project-disseminating-quality-improvement-data-study-protocol-for-a-mixed-methods-study
#4
Alison Laycock, Jodie Bailie, Veronica Matthews, Frances Cunningham, Gillian Harvey, Nikki Percival, Ross Bailie
INTRODUCTION: Bringing together continuous quality improvement (CQI) data from multiple health services offers opportunities to identify common improvement priorities and to develop interventions at various system levels to achieve large-scale improvement in care. An important principle of CQI is practitioner participation in interpreting data and planning evidence-based change. This study will contribute knowledge about engaging diverse stakeholders in collaborative and theoretically informed processes to identify and address priority evidence-practice gaps in care delivery...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28710211/occupational-risk-for-legionella-infection-among-dental-healthcare-workers-meta-analysis-in-occupational-epidemiology
#5
Stefano Petti, Matteo Vitali
OBJECTIVE: The occupational risk for Legionella infection among dental healthcare workers (DHCWs) is conjectured because of the risk of routine inhalation of potentially contaminated aerosols produced by the dental instruments. Nevertheless, occupational epidemiology studies are contrasting. This meta-analysis assessed the level of scientific evidence regarding the relative occupational risk for Legionella infection among DHCWs. METHODS: Literature search was performed without time and language restrictions, using broad data banks (PubMed, Scopus, Web of Science, GOOGLE Scholar) and generic keywords ('legionella' AND 'dent*')...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28702608/point-of-care-testing-applications-of-3d-printing
#6
REVIEW
Ho Nam Chan, Ming Jun Andrew Tan, Hongkai Wu
Point-of-care testing (POCT) devices fulfil a critical need in the modern healthcare ecosystem, enabling the decentralized delivery of imperative clinical strategies in both developed and developing worlds. To achieve diagnostic utility and clinical impact, POCT technologies are immensely dependent on effective translation from academic laboratories out to real-world deployment. However, the current research and development pipeline is highly bottlenecked owing to multiple restraints in material, cost, and complexity of conventionally available fabrication techniques...
July 12, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28701226/the-application-of-geographic-information-systems-gis-in-identifying-the-priority-areas-for-maternal-care-and-services
#7
Fatemeh Salehi, Leila Ahmadian
BACKGROUND: Improving maternal health is globally introduced as an important health priority. The purpose of this study is to identify the high priority areas which require more maternal health services in Kerman, Iran. METHODS: This is a descriptive cross-sectional study, performed in 2015. The literatures were first explored in order to extract geographic indicators and sub indicators relevant to the maternal health. Data were collected by the use of a questionnaire designed on the basis of AHP (Analytic Hierarchy Process) method...
July 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28699779/indication-specific-pricing-of-pharmaceuticals-in-the-us-healthcare-system
#8
Steven D Pearson, William B Dreitlein, Chris Henshall, Adrian Towse
AIM: To explore the potential of indication-specific pricing (ISP) of pharmaceuticals and to discuss prospects for implementation in the US healthcare system. MATERIALS & METHODS: The Institute for Clinical and Economic Review convened a policy forum with 44 healthcare leaders from 22 payer and life sciences companies. Models of ISP were discussed. RESULTS: Payers and drug manufacturers saw the potential benefits of an ISP system that balances affordability for payers, sustainability for manufacturers and access for patients...
July 12, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28697108/economic-evaluation-of-adjunctive-azithromycin-prophylaxis-for-cesarean-delivery
#9
Lorie M Harper, Meredith Kilgore, Jeff M Szychowski, William W Andrews, Alan T N Tita
OBJECTIVE: To compare the costs associated with adjunctive azithromycin compared with standard cefazolin antibiotic prophylaxis alone for unscheduled and scheduled cesarean deliveries. METHODS: A decision analytic model was created to compare cefazolin alone with azithromycin plus cefazolin. Published incidences of surgical site infection after cesarean delivery were used to estimate the baseline incidence of surgical site infection in scheduled and unscheduled cesarean delivery using standard antibiotic prophylaxis...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28695441/health-care-cost-consequences-of-using-robot-technology-for-hysterectomy-a-register-based-study-of-consecutive-patients-during-2006-2013
#10
Karin Rosenkilde Laursen, Vibe Bolvig Hyldgård, Pernille Tine Jensen, Rikke Søgaard
The objective of this study is to examine the costs attributable to robotic-assisted laparoscopic hysterectomy from a broad healthcare sector perspective in a register-based longitudinal study. The population in this study were 7670 consecutive women undergoing hysterectomy between January 2006 and August 2013 in public hospitals in Denmark. The interventions in the study were total and radical hysterectomy performed robotic-assisted laparoscopic hysterectomy (RALH), total laparoscopic hysterectomy (TLH), or open abdominal hysterectomy (OAH)...
July 10, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28693548/using-a-linked-database-for-epidemiology-across-the-primary-and-secondary-care-divide-acute-kidney-injury
#11
M Johnson, H Hounkpatin, S Fraser, D Culliford, M Uniacke, P Roderick
BACKGROUND: NHS England has mandated the use in hospital laboratories of an automated early warning algorithm to create a consistent method for the detection of acute kidney injury (AKI). It generates an 'alert' based on changes in serum creatinine level to notify attending clinicians of a possible incident case of the condition, and to provide an assessment of its severity. We aimed to explore the feasibility of secondary data analysis to reproduce the algorithm outside of the hospital laboratory, and to describe the epidemiology of AKI across primary and secondary care within a region...
July 11, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28688188/quality-indicators-of-laryngeal-cancer-care-in-commercially-insured-patients
#12
Christopher J Britt, Hsien-Yen Chang, Harry Quon, Hyunseok Kang, Ana P Kiess, David W Eisele, Kevin D Frick, Christine G Gourin
OBJECTIVE: To examine associations between quality, complications, and costs in commercially insured patients treated for laryngeal cancer. STUDY DESIGN: Retrospective cross-sectional analysis of MarketScan Commercial Claim and Encounters data (Truven Health Analytics, Ann Arbor, Michigan, U.S.A.). METHODS: We evaluated 10,969 patients diagnosed with laryngeal cancer from 2010 to 2012 using cross-tabulations and multivariate regression. Using quality indicators derived from guidelines for recommended care, summary measures of quality were calculated for diagnosis, initial treatment, surveillance, treatment for recurrence, performance, and an overall summary measure of quality...
July 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28685304/perioperative-and-icu-healthcare-analytics-within-a-veterans-integrated-system-network-a-qualitative-gap-analysis
#13
Seshadri Mudumbai, Ferenc Ayer, Jerry Stefanko
Health care facilities are implementing analytics platforms as a way to document quality of care. However, few gap analyses exist on platforms specifically designed for patients treated in the Operating Room, Post-Anesthesia Care Unit, and Intensive Care Unit (ICU). As part of a quality improvement effort, we undertook a gap analysis of an existing analytics platform within the Veterans Healthcare Administration. The objectives were to identify themes associated with 1) current clinical use cases and stakeholder needs; 2) information flow and pain points; and 3) recommendations for future analytics development...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28683704/pharmacokinetic-monitoring-of-chronic-treatment-with-digoxin-from-primary-health-care
#14
Emma M García-Iranzo, Francisco J Rodríguez-Lucena, Carmen Matoses-Chirivella, Ana García-Monsalve, Ana Cristina Murcia-López, Andrés Navarro-Ruiz
INTRODUCTION: The serum digoxin concentration (SDC) should be between 0.8 and 2 ng/ml. The objective is to assess the pharmacokinetic monitoring of SDC performed from primary healthcare (PH) in patients with chronic treatment. METHODS: Cross-sectional retrospective study of patients with chronic treatment with digoxin belonging to the department of a General University Hospital.Data were analized: age, sex, diagnosis, number of serum digoxin concentration determinations, date and origin of the request for monitoring, analytical result and pharmacokinetic assessment are collected...
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28683703/influence-of-hospital-admission-in-the-pharmacotherapy-complexity-of-hiv-patients
#15
María de Las Aguas Robustillo Cortés, Ramón Morillo Verdugo, Esther María Barreiro Fernández, Ascensión Pavón Plata, Patricia Monje Agudo
OBJECTIVE: To determine the variation in the pharmacotherapy complexity index in HIV+ patients after hospital admission. METHOD: A retrospective, single-center study with HIV+ patients on antiretroviral treatment (ART) who were admitted to hospital between 2008 and 2015 were conducted. Demographic, analytical, clinical and pharmacotherapy variables were collected, as well as those about the use of healthcare resources. The primary endpoint was the variation in the overall complexity index after a hospital admission, measured through the MRCI tool (University of Colorado)...
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28683175/cost-effectiveness-analysis-of-30-month-vs-12-month-dual-antiplatelet-therapy-with-clopidogrel-and-aspirin-after-drug-eluting-stents-in-patients-with-acute-coronary-syndrome
#16
Minghuan Jiang, Joyce H S You
Continuation of dual antiplatelet therapy (DAPT) beyond 1 year reduces late stent thrombosis and ischemic events after drug-eluting stents (DES) but increases risk of bleeding. We hypothesized that extending DAPT from 12 months to 30 months in patients with acute coronary syndrome (ACS) after DES is cost-effective. A lifelong decision-analytic model was designed to simulate 2 antiplatelet strategies in event-free ACS patients who had completed 12-month DAPT after DES: aspirin monotherapy (75-162 mg daily) and continuation of DAPT (clopidogrel 75 mg daily plus aspirin 75-162 mg daily) for 18 months...
July 6, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28679909/real-time-process-analytics-in-emergency-healthcare
#17
Vassiliki Koufi, Flora Malamateniou, Adrianna Prentza, George Vassilacopoulos
Emergency medical systems (EMS) are considered to be amongst the most crucial systems as they involve a variety of activities which are performed from the time of a call to an ambulance service till the time of patient's discharge from the emergency department of a hospital. These activities are closely interrelated so that collaboration and coordination becomes a vital issue for patients and for emergency healthcare service performance. The utilization of standard workflow technology in the context of Service Oriented Architecture can provide an appropriate technological infrastructure for defining and automating EMS processes that span organizational boundaries so that to create and empower collaboration and coordination among the participating organizations...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28678899/incidence-of-phlebitis-and-post-infusion-phlebitis-in-hospitalised-adults
#18
Janete de Souza Urbanetto, Franciele de Oliveira Minuto Muniz, Renata Martins da Silva, Ana Paula Christo de Freitas, Ana Paula Ribeiro de Oliveira, Jessica de Cassia Ramos Dos Santos
Objective: to determine the incidence of phlebitis during and after the use of peripheral intravenous catheter (PIC), and analyse the association of this complication with risk factors. Methods: cohort study with 165 adult patients admitted to a university hospital in Porto Alegre, totalling 447 accesses, from December 2014 to February 2015. Data were collected on a daily basis and analysed by means of descriptive and analytical statistics. Results: The incidence of phlebitis during PIC was 7...
June 29, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28671478/a-qualitative-study-exploring-factors-influencing-clinical-decision-making-for-influenza-like-illness-in-solapur-city-maharashtra-india
#19
A S Ahankari, P R Myles, S Tsang, F Khan, S Atre, T Langley, A Kudale, M Bains
The co-existence of different types of medical systems (medical pluralism) is a typical feature of India's healthcare system. For conditions such as influenza-like illness (ILI), where non-specific disease signs/symptoms exist, clinical reasoning in the context of medical pluralism becomes crucial. Recognising this need, we undertook a qualitative study, which explored factors underpinning clinical decisions on diagnosis and management of ILI. The study involved semi-structured interviews including clinical vignettes with 20 healthcare practitioners (working within allopathy, homeopathy and Ayurveda) working in the private healthcare sector in Solapur city, India...
July 3, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28670588/knowledge-attitude-and-practice-of-community-health-workers-regarding-child-abuse-in-tabriz-health-centers-in-2015-2016
#20
Mohammad Hasan Sahebihagh, Seyedeh Zahra Hosseini, Mina Hosseinzadeh, Seyed Morteza Shamshirgaran
BACKGROUND: Child abuse is a widespread social phenomenon with serious life-time consequences. Since parents bring their children to healthcare centers for growth screening and vaccinations, Community Health Workers play an important role in identifying and reporting child abuse cases. Thus, the current study aimed to investigate knowledge, attitude and performance of Community Health Workers regarding child abuse in Tabriz. METHODS: This is a descriptive (cross-sectional) study; census method was used for sampling...
July 2017: International Journal of Community Based Nursing and Midwifery
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