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https://www.readbyqxmd.com/read/28081385/catheter-related-bloodstream-infections-in-adults-receiving-home-parenteral-nutrition
#1
Siri Tribler, Christopher F Brandt, Mark Hvistendahl, Michael Staun, Per Brøbech, Claus E Moser, Palle B Jeppesen
BACKGROUND: A common complication in patients receiving home parenteral nutrition (HPN) is catheter-related bloodstream infections (CRBSIs). The CRBSI incidence has been advocated as an outcome parameter assessing the quality of care. This study aimed to illustrate how the use of different CRBSI definitions affects the reported incidence. MATERIALS AND METHODS: In an observational study based on the Copenhagen intestinal failure database, all clinically reported CRBSIs from 2002-2013 were compared with data from the affiliated microbiological database according to recommended CRBSI criteria...
January 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28078825/ethanol-combined-with-heparin-as-a-locking-solution-for-the-prevention-of-catheter-related-blood-stream-infections-in-hemodialysis-patients-a-prospective-randomized-study
#2
Sofia Sofroniadou, Ioanna Revela, Alexandros Kouloubinis, Ioanna Makriniotou, Sinodi Zerbala, Despina Smirloglou, Petros Kalocheretis, Apostolos Drouzas, George Samonis, Christos Iatrou
Introduction Ethanol lock solution has been mainly administered in paediatric and home parenteral nutrition patients in order to prevent catheter related blood stream infections (CRBSI). Its utility in hemodialysis (HD) patients with non-tunneled-uncuffed catheter (NTC) has been poorly explored. Methods We conducted a prospective randomized study in chronic HD patients requiring a newly inserted NTC-while awaiting for the maturation of an already established arteriovenous fistula (AVF) or arteriovenous graft (AVG) or tunneled-cuffed catheter insertion...
January 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28035620/does-antimicrobial-lock-solution-reduce-catheter-related-infections-in-hemodialysis-patients-with-central-venous-catheters-a-bayesian-network-meta-analysis
#3
Jun Zhang, Bo Wang, Rongke Li, Long Ge, Kee-Hsin Chen, Jinhui Tian
PURPOSE: The purpose of our study is to carry out a Bayesian network meta-analysis comparing the efficacy of different antimicrobial lock solutions (ALS) for prevention of catheter-related infections (CRI) in patients with hemodialysis (HD) and ranking these ALS for practical consideration. METHODS: We searched six electronic databases, earlier relevant meta-analysis and reference lists of included studies for randomized controlled trials (RCTs) that compared ALS for preventing episodes of CRI in patients with HD either head-to-head or against control interventions using non-ALS...
December 29, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/28005691/clinical-and-bacterial-risk-factors-for-mortality-in-children-with-carbapenem-resistant-enterobacteriaceae-bloodstream-infections-in-india
#4
Laura E B Nabarro, Chaitra Shankar, Akila Prakasam, Georgekutty Mathew, Visali Jeyaseelan, Balaji Veeraraghavan, Valsan P Verghese
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) are an increasing cause of nosocomial infection in hospitalized children worldwide. Few studies have investigated risk factors for mortality in children with CRE bloodstream infection (BSI). Data are particularly scarce in areas where NDM and OXA carbapenemases predominate. Here, we investigate mortality rates, clinical and microbiologic risk factors for mortality in 50 pediatric patients with CRBSI in India. METHOD: Children younger than 17 years old with meropenem-resistant Klebsiella pneumoniae or Escherichia coli isolated from blood culture in 2014 and 2015 were identified from laboratory records...
December 21, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27872830/bacteremia-in-hemodialysis-patients
#5
REVIEW
Masashi Suzuki, Nobuhiko Satoh, Motonobu Nakamura, Shoko Horita, George Seki, Kyoji Moriya
Infection is a common complication and is the second leading cause of death in hemodialysis patients. The risk of bacteremia in hemodialysis patients is 26-fold higher than in the general population, and 1/2-3/4 of the causative organisms of bacteremia in hemodialysis patients are Gram-positive bacteria. The ratio of resistant bacteria in hemodialysis patients compared to the general population is unclear. Several reports have indicated that hemodialysis patients have a higher risk of methicillin-resistant Staphylococcus aureus infection...
November 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27846059/taurolidine-in-pediatric-home-parenteral-nutrition-patients
#6
Emma Claire Hulshof, Lidwien Marieke Hanff, Joanne Olieman, Susanna de Vette, Gert-Jan Driessen, Conny Meeussen, Johanna Caroline Escher
To reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients, the use of taurolidine was introduced in the Sophia Children's Hospital in 2011. This introduction led to a reduction in catheter-related bloodstream infections: 12.7/1000 catheter days before the use of taurolidine, compared with 4.3/1000 catheter days afterwards (n = 7) [relative risk = 0.36, 95% confidence interval: 0.20-0.65 (P = 0.018)].
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27816140/prevention-of-vascular-catheter-related-bloodstream-infections
#7
REVIEW
Mark E Rupp, Denisa Majorant
Catheter-related bloodstream infections (CRBSI) are responsible for significant morbidity, mortality, and excess health care costs. It is increasingly evident that many CRBSI can be prevented with current knowledge and techniques. Preventive measures can be broadly grouped into clinical practice-based interventions and technologic innovations. Clinical practice-based interventions require changes in human behavior and can be subdivided into interventions before and at the time of insertion and postinsertion...
December 2016: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/27775764/economic-evaluation-of-quality-improvement-interventions-for-bloodstream-infections-related-to-central-catheters-a-systematic-review
#8
Teryl K Nuckols, Emmett Keeler, Sally C Morton, Laura Anderson, Brian Doyle, Marika Booth, Roberta Shanman, Jonathan Grein, Paul Shekelle
Importance: Although quality improvement (QI) interventions can reduce central-line-associated bloodstream infections (CLABSI) and catheter-related bloodstream infections (CRBSI), their economic value is uncertain. Objective: To systematically review economic evaluations of QI interventions designed to prevent CLABSI and/or CRBSI in acute care hospitals. Evidence Review: A search of Ovid MEDLINE, Econlit, Centre for Reviews & Dissemination, New York Academy of Medicine's Grey Literature Report, Worldcat, prior systematic reviews (January 2004 to July 2016), and IDWeek conference abstracts (2013-2016), was conducted from 2013 to 2016...
December 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27730778/antibiotic-lock-therapy-in-the-era-of-gram-negative-resistance
#9
Rajeev Soman, Neha Gupta, Mitesh Suthar, Jatin Kothari, Alan Almeida, Anjali Shetty, Camilla Rodrigues
BACKGROUND: Central-line-associated blood-stream infection (CLABSI) is a highly consequential nosocomial infection. The most effective management includes the removal of the infected catheter. Retention of the catheter and antibiotic lock therapy (ALT) along with systemic antibiotics may be attempted only if there are unusual extenuating circumstances. CLABSIs due to Gram-negative bacteria (GNB) is more common in our setting and the organisms are often highly resistant. Hence, there is a need to explore the use of novel antimicrobials for catheter lock solutions along with antibiofilm agents...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27645121/risk-factors-for-persistent-bacteremia-in-infants-with-catheter-related-bloodstream-infection-due-to-coagulase-negative-staphylococcus-in-the-neonatal-intensive-care-unit
#10
Munehiro Furuichi, Isao Miyairi
BACKGROUND: Coagulase-negative Staphylococcus (CoNS) is the predominant cause of catheter-related bloodstream infections (CRBSI). Infants in neonatal intensive care units (NICU) often suffer from CoNS CRBSI, which are often refractory to treatment. OBJECTIVES: We sought to evaluate risk factors for developing persistent bacteremia due to CoNS CRBSI in infants, in order to identify those who require early aggressive management. METHODS: We conducted a retrospective case-control study of infants in the NICU who developed CRBSI due to CoNS...
December 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27630843/microbiology-of-non-tunnelled-catheter-related-infections
#11
Shefali Gupta, Shrikara P Mallya, Ashok Bhat, Shrikala Baliga
INTRODUCTION: Aerobic bacterial infections often complicate vascular access in patients receiving haemodialysis, leading to Catheter-Related Blood Stream Infections (CRBSI). Various studies report Gram - positive bacteria, Staphylococcus aureus (S. aureus) in particular, as the most common aetiologic agent. Studies on microbiological analysis in this subset of population from India are very few. AIM: To examine clinical and bacteriological profiles of haemodialysis patients developing CRBSI, the antibiotic susceptibility of the bacteria isolated from these patients and determine nasal carriage of S...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27582899/economic-impact-of-tegaderm-chlorhexidine-gluconate-chg-dressing-in-critically-ill-patients
#12
Praveen Thokala, Martin Arrowsmith, Edith Poku, Marissa Martyn-St James, Jeff Anderson, Steve Foster, Tom Elliott, Tony Whitehouse
PURPOSE: To estimate the economic impact of a Tegaderm(TM) chlorhexidine gluconate (CHG) gel dressing compared with a standard intravenous (i.v.) dressing (defined as non-antimicrobial transparent film dressing), used for insertion site care of short-term central venous and arterial catheters (intravascular catheters) in adult critical care patients using a cost-consequence model populated with data from published sources. MATERIAL AND METHODS: A decision analytical cost-consequence model was developed which assigned each patient with an indwelling intravascular catheter and a standard dressing, a baseline risk of associated dermatitis, local infection at the catheter insertion site and catheter-related bloodstream infections (CRBSI), estimated from published secondary sources...
September 2016: Journal of Infection Prevention
https://www.readbyqxmd.com/read/27573387/comparative-effectiveness-of-30%C3%A2-trisodium-citrate-and-heparin-lock-solution-in-preventing-infection-and-dysfunction-of-hemodialysis-catheters-a-randomized-controlled-trial-citrim-trial
#13
Franklin Correa Barcellos, Bruno Pereira Nunes, Luciana Jorge Valle, Thiago Lopes, Bianca Orlando, Cintia Scherer, Marcia Nunes, Gabriela Araújo Duarte, Maristela Böhlke
BACKGROUND: Central venous catheters (CVC) are the only option when hemodialysis is needed for patients without definitive vascular access. However, CVC is associated with complications, such as infection, thrombosis, and dysfunction, leading to higher mortality and expenditures. The aim of this study was to compare the effectiveness of 30 % trisodium citrate (TSC30 %) with heparin as CVC lock solutions in preventing catheter-related bloodstream infections (CRBSI) and dysfunction in hemodialysis patients...
August 29, 2016: Infection
https://www.readbyqxmd.com/read/27488325/catheter-related-blood-stream-infection-in-patients-receiving-long-term-home-parenteral-nutrition-tertiary-care-hospital-experience-in-saudi-arabia
#14
Esraa S Al-Tawil, Alanoud M Almuhareb, Hamdy M Amin
BACKGROUND/AIM: Parenteral nutrition (PN) is a lifesaving therapy for patients with many severe conditions, including intestinal failure. Some patients require long-term PN therapy, which makes home parenteral nutrition (HPN) an attractive option to improve the quality of life. Among the most common and serious complications observed in these patients are catheter-related blood stream infections (CRBSIs). The aim of our study is to determine the frequency of CRBSI among patients receiving long-term HPN...
July 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27474228/the-long-term-effect-of-bundle-care-for-catheter-related-blood-stream-infection-5-year-follow-up
#15
Ho-Tsung Hsin, Meng-Shiuan Hsu, Jiann-Shing Shieh
OBJECTIVE: To address the importance of bundle care for catheter-related infection (CRBSI) on the basis of long-term observation in a catheter-abundant cardiovascular intensive care unit (CVICU). DESIGN: Prospective longitudinal cohort study. SETTING: CVICU of a tertiary referring medical centre in northern Taiwan. PARTICIPANTS: Around 1400 critically ill patients annually for 5 years in the CVICU (from January 2010 to June 2015)...
July 29, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27461433/efficacy-of-ethanol-locks-to-reduce-the-incidence-of-catheter-related-bloodstream-infections-for-home-parenteral-nutrition-pediatric-patients-comparison-of-therapeutic-treatment-with-prophylactic-treatment
#16
Takafumi Kawano, Tatsuru Kaji, Shun Onishi, Koji Yamada, Waka Yamada, Kazuhiko Nakame, Motoi Mukai, Satoshi Ieiri
PURPOSE: Children with intestinal failure (IF) requiring central venous catheters (CVCs) often experience frequent catheter-related bloodstream infections (CRBSIs), which is a serious and life-threatening complication. To reduce the incidence of CRBSI, prophylactic ethanol lock therapy (ELT) was initiated. METHODS: Patients with IF received home parenteral nutrition via a silicone tunneled CVC. All of them had received therapeutic ELT from January 2009 (first period) and prophylactic ELT from December 2012 (second period)...
September 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27456299/a-randomized-trial-on-chlorhexidine-dressings-for-the-prevention-of-catheter-related-bloodstream-infections-in-neutropenic-patients
#17
L M Biehl, A Huth, J Panse, C Krämer, M Hentrich, M Engelhardt, K Schäfer-Eckart, G Kofla, M Kiehl, C-M Wendtner, M Karthaus, A J Ullmann, M Hellmich, H Christ, M J G T Vehreschild
BACKGROUND: Central venous catheter (CVC)-related bloodstream infections (CRBSI) are a frequent cause of morbidity and mortality in patients with chemotherapy-induced neutropenia. Chlorhexidine containing catheter securement dressings may prevent CRBSI. PATIENTS AND METHODS: A multicenter randomized, controlled trial was conducted at 10 German hematology departments. We compared chlorhexidine-containing dressings with non-chlorhexidine control dressings in neutropenic patients...
October 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27410189/skin-antisepsis-for-reducing-central-venous-catheter-related-infections
#18
REVIEW
Nai Ming Lai, Nai An Lai, Elizabeth O'Riordan, Nathorn Chaiyakunapruk, Jacqueline E Taylor, Kenneth Tan
BACKGROUND: The central venous catheter (CVC) is a device used for many functions, including monitoring haemodynamic indicators and administering intravenous medications, fluids, blood products and parenteral nutrition. However, as a foreign object, it is susceptible to colonisation by micro-organisms, which may lead to catheter-related blood stream infection (BSI) and in turn, increased mortality, morbidities and health care costs. OBJECTIVES: To assess the effects of skin antisepsis as part of CVC care for reducing catheter-related BSIs, catheter colonisation, and patient mortality and morbidities...
July 13, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27402781/penetration-barrier-contributes-to-bacterial-biofilm-associated-resistance-against-only-select-antibiotics-and-exhibits-genus-strain-and-antibiotic-specific-differences
#19
Rachna Singh, Simmi Sahore, Preetinder Kaur, Alka Rani, Pallab Ray
Bacterial biofilms are implicated in a wide range of implant-based and chronic infections. These infections are often associated with adverse therapeutic outcomes, owing to the decreased antibiotic susceptibility of biofilms compared with their planktonic counterparts. This altered biofilm susceptibility has been attributed to multiple factors, including a reduced antibiotic penetration. Although several studies have addressed the role of penetration barrier in biofilm-associated drug resistance, it remains inconclusive...
August 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27378009/chlorhexidine-silver-sulfadiazine-impregnated-venous-catheters-are-efficient-even-at-subclavian-sites-without-tracheostomy
#20
Leonardo Lorente, María Lecuona, Alejandro Jiménez, Judith Cabrera, Ruth Santacreu, Lisset Lorenzo, Lorena Raja, María L Mora
BACKGROUND: Chlorhexidine-silver sulfadiazine (CHSS)-impregnated catheters have been found to decrease the risk of catheter-related bloodstream infection (CRBSI) and central venous catheter (CVC)-related costs. However, there are no published data about cost-effectiveness of the use of CHSS-impregnated catheters in subclavian venous access without the presence of tracheostomy (thus, with a very low risk of CRBSI). That was the objective of this study. METHODS: This was a retrospective study of patients admitted to a mixed intensive care unit who underwent placement of subclavian venous catheters without the presence of tracheostomy...
December 1, 2016: American Journal of Infection Control
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