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https://www.readbyqxmd.com/read/28445941/palliative-radiotherapy-for-gastric-cancer-a-systematic-review-and-meta-analysis
#1
REVIEW
Jeremy Tey, Yu Yang Soon, Wee Yao Koh, Cheng Nang Leong, Bok Ai Choo, Francis Ho, Balamurugan Vellayappan, Keith Lim, Ivan Wk Tham
BACKGROUND/PURPOSE: To review the efficacy and toxicity of palliative radiotherapy (RT) for symptomatic locally advanced gastric cancer (GC) and to determine the optimal RT schedule for symptom palliation. METHODS: We searched MEDLINE and CENTRAL for eligible studies published from 1995 to 2015. Outcomes of interest were relief of bleeding, pain and obstruction. RESULTS: Seven non-comparative observational studies were included. There were large variations in RT dose and fractionation...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445930/opioids-modulators-of-angiogenesis-in-wound-healing-and-cancer
#2
REVIEW
Martina Ondrovics, Andrea Hoelbl-Kovacic, Daniela Alexandra Fux
Opioids are potent drugs that are widely used to control wound or cancer pain. Increasing evidence suggest that opioids mediate clinically relevant effects that go beyond their classical role as analgesics. Of note, opioids appear to modulate angiogenesis - a process that is critical in wound healing and cancer progression. In this review, we focus on pro- and anti-angiogenic facets of opioids that arise from the activation of individual opioid receptors and the usage of individual concentrations or application routes...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445919/making-a-difference-pragmatic-paediatric-pain-management
#3
Ben Lawton, Henry Goldstein, Tessa Davis, Andrew Tagg
No abstract text is available yet for this article.
April 26, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28445889/genetic-polymorphisms-in-aromatase-cyp19a1-are-not-associated-with-gonadal-phenotypes-in-red-eared-slider-turtle-hatchlings-developed-at-a-pivotal-temperature
#4
Yuiko Matsumoto, David Crews
Embryonic gonad sex in many reptilian species is determined by the incubation temperature of the egg, a differentiation process known as temperature-dependent sex determination (TSD). Incubation at the pivotal temperature (PvT) results in approximately an equal number of offspring of both sexes. We investigated the potential contribution of genetic variations that drives the gonadal differentiation into testes or ovaries under this temperature in the red-eared slider turtle (Trachemys scripta). Four male and 4 female hatchlings of eggs that had been incubated at the PvT were examined for polymorphisms at an approximately 23-kb region of the aromatase (cyp19a1) gene...
April 27, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28445862/treatments-of-traumatic-neuropathic-pain-a-systematic-review
#5
Chenglun Yao, Xijie Zhou, Bin Zhao, Chao Sun, Keshav Poonit, Hede Yan
Traumatic neuropathic pain caused by traumatic neuroma has long been bothering both doctors and patients, the mechanisms of traumatic neuropathic pain are widely discussed by researchers and the treatment is challenging. Clinical treatment of painful neuroma is unclear. Numerous treatment modalities have been introduced by experts in this field. However, there is still no single standard recognized treatment.Different forms of treatments have been tested in animals and humans, but pharmacotherapies (antidepressants, antiepileptics) remain the basis of traumatic neuropathic pain management...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445853/cannabidiol-%C3%AE-9-tetrahydrocannabinol-interactions-on-acute-pain-and-locomotor-activity
#6
Stevie C Britch, Jenny L Wiley, Zhihao Yu, Brian H Clowers, Rebecca M Craft
BACKGROUND: Previous studies suggest that cannabidiol (CBD) may potentiate or antagonize Δ(9)-tetrahydrocannabinol's (THC) effects. The current study examined sex differences in CBD modulation of THC-induced antinociception, hypolocomotion, and metabolism. METHODS: In Experiment 1, CBD (0, 10 or 30mg/kg) was administered 15min before THC (0, 1.8, 3.2, 5.6 or 10mg/kg), and rats were tested for antinociception and locomotion 15-360min post-THC injection. In Experiments 2 and 3, CBD (30mg/kg) was administered 13h or 15min before THC (1...
April 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28445777/five-year-follow-up-after-laparoscopic-large-nerve-resection-for-deep-infiltrating-sciatic-nerve-endometriosis
#7
Marc Possover
STUDY OBJECTIVE: To report neurologic follow-up of patients after laparoscopic large resection of deep infiltrating endometriosis of the sciatic nerve. DESIGN: Prospective clinical case series (Canadian Task Force classification I). SETTING: Tertiary referral unit specializing in advanced gynecologic surgery and neuropelveology. PATIENTS: All data for patients who underwent laparoscopic surgery for endometriosis of the sciatic nerve between 2004 and 2016 (N = 259) were documented prospectively...
April 23, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28445756/membrane-mechanics-of-primary-afferent-neurons-in-the-dorsal-root-ganglia-of-rats
#8
Hirosato Kanda, Jianguo G Gu
Membrane mechanics is an important biological factor regulating many cellular functions including cell motility, intercellular and intracellular signaling, gene expression, and membrane ion channel activity. Primary afferent neurons transduce sensory information about temperature, touch, and pain. These sensory functions may be profoundly affected by the states of primary afferent neuron mechanics. However, membrane mechanics of primary afferent neurons is largely unknown. In this study, we established the optical trapping technique for determining membrane mechanics of cultured primary afferent neurons of the dorsal root ganglia (DRG)...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445709/gait-analysis-and-weight-bearing-in-pre-clinical-joint-pain-research
#9
Kristina Ängeby Möller, Heta Svärd, Anni Suominen, Jarmo Immonen, Johanna Holappa, Carina Stenfors
BACKGROUND: There is a need for better joint pain treatment, but development of new medication has not been successful. Pre-clinical models with readouts that better reflect the clinical situation are needed. In patients with joint pain, pain at rest and pain at walking are two major complaints. NEW METHOD: We describe a new way of calculating results from gait analysis using the CatWalk™ setup. Rats with monoarthritis induced by injection of Complete Freund's Adjuvant (CFA) intra-articularly into the ankle joint of one hind limb were used to assess gait and dynamic weight bearing...
April 23, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28445708/flow-cytometry-analysis-of-inflammatory-cells-isolated-from-the-sciatic-nerve-and-drg-after-chronic-constriction-injury-in-mice
#10
Liping Liu, Yan Yin, Fei Li, Charvi Malhotra, Jianguo Cheng
BACKGROUND: Cellular responses to nerve injury play a central role in the pathogenesis of neuropathic pain. However, the analysis of site specific cellular responses to nerve injury and neuropathic pain is limited to immunohistochemistry staining with numerous limitations. NEW METHODS: We proposed to apply flow cytometry to overcome some of the limitations and developed two protocols for isolation of cells from small specimens of the sciatic nerve and dorsal root ganglion (DRG) in mice...
April 23, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28445702/an-early-history-of-anesthesia-in-labor
#11
Mary E Gibson
Fear of pain often overshadows childbirth, and each woman must decide whether to receive anesthesia to combat labor pain. Historically, this choice resulted in unintended consequences and marked the beginnings of medical interventions in labor and birth. The purpose of this article is to trace the use of anesthesia in childbirth from the mid-19th to the mid-20th centuries and to explore its influence on childbearing women and nurses.
April 23, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28445695/neural-correlates-of-evoked-phantom-limb-sensations
#12
J Andoh, M Diers, C Milde, C Köppe, D Kleinböhl, H Flor
Previous work showed the existence of changes in the topographic organization within the somatosensory cortex (SI) in amputees with phantom limb pain, however, the link between nonpainful phantom sensations such as cramping or tingling or the percept of the limb and cortical changes is less clear. We used functional magnetic resonance imaging (fMRI) in a highly selective group of limb amputees who experienced inducible and reproducible nonpainful phantom sensations. A standardized procedure was used to locate body sites eliciting phantom sensations in each amputee...
April 23, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28445491/how-people-used-ochre-at-rose-cottage-cave-south-africa-sixty-thousand-years-of-evidence-from-the-middle-stone-age
#13
Tammy Hodgskiss, Lyn Wadley
We describe colour, hardness, grain size, geological type and surface modifications of ochre pieces excavated, first by Malan and later by Harper, from the Middle Stone Age (MSA) of Rose Cottage Cave, 96, 000 to 30, 000 years ago. Soft, bright-red shales are abundant, and most ochre has clayey or silty grain sizes. The post-Howiesons Poort layers contain the most ochre pieces, but the Howiesons Poort layers have the highest frequency of ochre per sediment volume. The pre-Howiesons Poort layers have the highest utilization rate...
2017: PloS One
https://www.readbyqxmd.com/read/28445438/reliability-and-validity-of-the-medical-outcomes-study-short-form-12-version-2-sf-12v2-in-adults-with-non-cancer-pain
#14
Corey J Hayes, Naleen Raj Bhandari, Niranjan Kathe, Nalin Payakachat
Limited evidence exists on how non-cancer pain (NCP) affects an individual's health-related quality of life (HRQoL). This study aimed to validate the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2), a generic measure of HRQoL, in a NCP cohort using the Medical Expenditure Panel Survey Longitudinal Files. The SF Mental Component Summary (MCS12) and SF Physical Component Summary (PCS12) were tested for reliability (internal consistency and test-retest reliability) and validity (construct: convergent and discriminant; criterion: concurrent and predictive)...
April 26, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28445436/irritable-bowel-syndrome-clinical-manifestations-dietary-influences-and-management
#15
REVIEW
Ronald Ikechi, Bradford D Fischer, Joshua DeSipio, Sangita Phadtare
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is characterized by symptoms of chronic abdominal pain and altered bowel habits in the absence of an overtly identifiable cause. It is the most commonly diagnosed functional gastrointestinal disorder, accounting for about one third of gastroenterology visits. It generally presents as a complex of symptoms, including psychological dysfunction. Hypersensitivity to certain foods, especially foods that contain high amounts of fructose, plays a role in the pathophysiology of IBS...
April 26, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28445412/assessing-the-efficacy-of-first-aid-measures-in-physalia-sp-envenomation-using-solution-and-blood-agarose-based-models
#16
Christie L Wilcox, Jasmine L Headlam, Thomas K Doyle, Angel A Yanagihara
Stings from the hydrozoan species in the genus Physalia cause intense, immediate skin pain and elicit serious systemic effects. There has been much scientific debate about the most appropriate first aid for these stings, particularly with regard to whether vinegar use is appropriate (most current recommendations recommend against vinegar). We found that only a small percentage (≤1.0%) of tentacle cnidae discharge during a sting event using an ex vivo tissue model which elicits spontaneous stinging from live cnidarian tentacles...
April 26, 2017: Toxins
https://www.readbyqxmd.com/read/28445406/a-pilot-study-of-mindfulness-meditation-for-pediatric-chronic-pain
#17
Lynn C Waelde, Amanda B Feinstein, Rashmi Bhandari, Anya Griffin, Isabel A Yoon, Brenda Golianu
Despite advances in psychological interventions for pediatric chronic pain, there has been little research examining mindfulness meditation for these conditions. This study presents data from a pilot clinical trial of a six-week manualized mindfulness meditation intervention offered to 20 adolescents aged 13-17 years. Measures of pain intensity, functional disability, depression and parent worry about their child's pain were obtained at baseline and post-treatment. Results indicated no significant changes in pain or depression, however functional disability and frequency of pain functioning complaints improved with small effect sizes...
April 26, 2017: Children
https://www.readbyqxmd.com/read/28445354/a-prospective-randomized-trial-comparing-the-effects-of-lidocaine-in-breast-reduction-surgery
#18
Brian M Christie, Sahil Kapur, Steve J Kempton, Summer E Hanson, Yue Ma, Venkat K Rao
BACKGROUND: Use of dilute epinephrine tumescent solution in breast reduction surgery has been shown to significantly decrease operative blood loss without increasing perioperative complications. Lidocaine is commonly added to epinephrine to decrease postoperative pain. Evidence supporting this practice, however, is limited, and lidocaine toxicity has been reported. METHODS: With institutional review board approval, patients undergoing bilateral breast reduction surgery were assigned to receive either tumescent saline solution with epinephrine (1:1 million) (group 1), or tumescent saline solution with epinephrine (1:1 million) and lidocaine (0...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445352/consensus-review-of-optimal-perioperative-care-in-breast-reconstruction-enhanced-recovery-after-surgery-eras-society-recommendations
#19
Claire Temple-Oberle, Melissa A Shea-Budgell, Mark Tan, John L Semple, Christiaan Schrag, Marcio Barreto, Phillip Blondeel, Jeremy Hamming, Joseph Dayan, Olle Ljungqvist
BACKGROUND: Enhanced recovery following surgery can be achieved through the introduction of evidence-based perioperative maneuvers. This review aims to present a consensus for optimal perioperative management of patients undergoing breast reconstructive surgery and to provide evidence-based recommendations for an enhanced perioperative protocol. METHODS: A systematic review of meta-analyses, randomized controlled trials, and large prospective cohorts was conducted for each protocol element...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445326/acceptance-in-chronic-neck-pain-associations-with-disability-and-fear-avoidance-beliefs
#20
Dave P Thompson, Steve R Woby
Chronic neck pain can result in significant levels of disability. Physiotherapy treatments often aim to modify cognitive factors and this approach benefits some, but not all, patients. Research from other pain conditions suggests that acceptance may be related to disability; however, it is unclear whether these associations exist in patients with neck pain. Moreover, it is unclear to what extent other cognitive factors are related to acceptance. Feasibly, if these factors are related, existing treatments may already be indirectly modifying acceptance...
April 25, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
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