keyword
https://read.qxmd.com/read/38425664/transferring-an-extremely-premature-infant-to-an-extra-uterine-life-support-system-a-prospective-view-on-the-obstetric-procedure
#1
REVIEW
Juliette S van Haren, Frank L M Delbressine, Mark Schoberer, Arjan B Te Pas, Judith O E H van Laar, S Guid Oei, M Beatrijs van der Hout-van der Jagt
To improve care for extremely premature infants, the development of an extrauterine environment for newborn development is being researched, known as Artificial Placenta and Artificial Womb (APAW) technology. APAW facilitates extended development in a liquid-filled incubator with oxygen and nutrient supply through an oxygenator connected to the umbilical vessels. This setup is intended to provide the optimal environment for further development, allowing further lung maturation by delaying gas exposure to oxygen...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38376866/statement-of-retraction-impacts-of-lipopolysaccharide-on-fetal-lung-developmental-maturity-and-surfactant-protein-b-and-surfactant-protein-c-protein-expression-in-gestational-diabetes-mellitus-rats
#2
https://read.qxmd.com/read/38370768/deciphering-endothelial-and-mesenchymal-organ-specification-in-vascularized-lung-and-intestinal-organoids
#3
Yifei Miao, Cheng Tan, Nicole M Pek, Zhiyun Yu, Kentaro Iwasawa, Daniel O Kechele, Nambirajan Sundaram, Victor Pastrana-Gomez, Keishi Kishimoto, Min-Chi Yang, Cheng Jiang, Jason Tchieu, Jeffrey A Whitsett, Kyle W McCracken, Robbert J Rottier, Darrell N Kotton, Michael A Helmrath, James M Wells, Takanori Takebe, Aaron M Zorn, Ya-Wen Chen, Minzhe Guo, Mingxia Gu
UNLABELLED: To investigate the co-development of vasculature, mesenchyme, and epithelium crucial for organogenesis and the acquisition of organ-specific characteristics, we constructed a human pluripotent stem cell-derived organoid system comprising lung or intestinal epithelium surrounded by organotypic mesenchyme and vasculature. We demonstrated the pivotal role of co-differentiating mesoderm and endoderm via precise BMP regulation in generating multilineage organoids and gut tube patterning...
February 7, 2024: bioRxiv
https://read.qxmd.com/read/38341166/survival-without-severe-neonatal-morbidity-after-antenatal-betamethasone-dose-reduction-a-post-hoc-analysis-of-a-randomized-non-inferiority-trial
#4
JOURNAL ARTICLE
Olivier Baud, Loic Sentilhes, Moreno Ursino, Muriel Doret-Dion, Corinne Alberti, Camille Aupiais, Thomas Schmitz
BACKGROUND: Antenatal betamethasone is recommended before preterm delivery to accelerate fetal lung maturation. However, its optimal dose remains unknown. A 50% dose reduction was proposed to decrease the potential dose-related long-term neurodevelopmental side effects, including psychological development, sleep, and emotional disorders. Because non-inferiority of the half-dose on the need for exogenous surfactant was not shown in the primary analysis, its impact on survival without major neonatal morbidity needs to be investigated...
February 8, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38319275/-histology-of-fetal-lungs-at-different-gestational-age
#5
JOURNAL ARTICLE
A G Talalaev, I S Davydov
The lecture is devoted to the morphological characteristics of the maturation of lung tissue structures in the fetal period. Fetal histology of the lungs presents the intrauterine development of lung tissue in four successive stages: pseudoglandular, canalicular, saccular and alveolar, each has specific morphological criteria. The following morphological features are predetermined: the development of alveolar epithelium, the ratio of mesenchyme towards the area in alveolar spaces, the degree of proliferation and location of vessels of the microcirculatory bed towards prealveolar partitions...
2024: Arkhiv Patologii
https://read.qxmd.com/read/38313196/ivim-morph-motion-compensated-quantitative-intra-voxel-incoherent-motion-ivim-analysis-for-functional-fetal-lung-maturity-assessment-from-diffusion-weighted-mri-data
#6
Noga Kertes, Yael Zaffrani-Reznikov, Onur Afacan, Sila Kurugol, Simon K Warfield, Moti Freiman
Quantitative analysis of pseudo-diffusion in diffusion-weighted magnetic resonance imaging (DWI) data shows potential for assessing fetal lung maturation and generating valuable imaging biomarkers. Yet, the clinical utility of DWI data is hindered by unavoidable fetal motion during acquisition. We present IVIM-morph, a self-supervised deep neural network model for motion-corrected quantitative analysis of DWI data using the Intra-voxel Incoherent Motion (IVIM) model. IVIM-morph combines two sub-networks, a registration sub-network, and an IVIM model fitting sub-network, enabling simultaneous estimation of IVIM model parameters and motion...
January 17, 2024: ArXiv
https://read.qxmd.com/read/38279281/glycogen-synthase-kinase-3-inhibition-by-chir99021-promotes-alveolar-epithelial-cell-proliferation-and-lung-regeneration-in-the-lipopolysaccharide-induced-acute-lung-injury-mouse-model
#7
JOURNAL ARTICLE
Raquel Fernandes, Catarina Barbosa-Matos, Caroline Borges-Pereira, Ana Luísa Rodrigues Toste de Carvalho, Sandra Costa
Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that currently lacks effective clinical treatments. Evidence highlights the potential role of glycogen synthase kinase-3 (GSK-3) inhibition in mitigating severe inflammation. The inhibition of GSK-3α/β by CHIR99021 promoted fetal lung progenitor proliferation and maturation of alveolar epithelial cells (AECs). The precise impact of CHIR99021 in lung repair and regeneration during acute lung injury (ALI) remains unexplored...
January 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38263448/leptin-deficiency-a-potential-mechanism-for-impaired-fetal-lung-development-in-uteroplacental-insufficiency
#8
JOURNAL ARTICLE
Srirupa Hari Gopal, Roopali Donepudi, Mohan Pammi
Uteroplacental insufficiency (UPI) is a major cause of fetal growth restriction (FGR). Leptin, an adipokine, has been shown to play a vital role in fetal organogenesis. There is evidence reporting leptin deficiency in preterm and growth-restricted fetuses. In this issue of Pediatric Research, Yuliana et al. report leptin expression and lung development in UPI-induced FGR rats. UPI-induced FGR rats expressed decreased lung leptin and had impaired lung development, as shown by decreased surface area and lung volume...
January 23, 2024: Pediatric Research
https://read.qxmd.com/read/38195368/the-impact-of-maternal-asthma-on-the-fetal-lung-outcomes-mechanisms-and-interventions
#9
REVIEW
Joshua L Robinson, Kathryn L Gatford, Vicki L Clifton, Janna L Morrison, Michael J Stark
Maternal asthma affects up to 17% of pregnancies and is associated with adverse infant, childhood, and adult respiratory outcomes, including increased risks of neonatal respiratory distress syndrome, childhood wheeze and asthma. In addition to genetics, these poor outcomes are likely due to the mediating influence of maternal asthma on the in-utero environment, altering fetal lung and immune development and predisposing the offspring to later lung disease. Maternal asthma may impair glucocorticoid signalling in the fetus, a process critical for lung maturation, and increase fetal exposure to proinflammatory cytokines...
December 23, 2023: Paediatric Respiratory Reviews
https://read.qxmd.com/read/38183316/gynecological-cancer-during-pregnancy-from-a-gyne-oncological-perspective
#10
JOURNAL ARTICLE
Katja Stenström Bohlin, Mats Brännström, Pernilla Dahm-Kähler
Gynecological cancer diagnosed during pregnancy requires accurate diagnosis and staging to determine optimal treatment based on gestational age. Cervical and ovarian cancers are the most common and multidisciplinary team collaboration is pivotal. Magnetic resonance imaging and ultrasound can be used without causing fetal harm. In cervical cancer, early-stage treatments can often be delayed until fetal lung maturation and cesarean section is recommended if disease prevails, in combination with a simple/radical hysterectomy and lymphadenectomy...
January 6, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38100545/early-human-lung-immune-cell-development-and-its-role-in-epithelial-cell-fate
#11
JOURNAL ARTICLE
Josephine L Barnes, Masahiro Yoshida, Peng He, Kaylee B Worlock, Rik G H Lindeboom, Chenqu Suo, J Patrick Pett, Anna Wilbrey-Clark, Emma Dann, Lira Mamanova, Laura Richardson, Krzysztof Polanski, Adam Pennycuick, Jessica Allen-Hyttinen, Iván T Herczeg, Romina Arzili, Robert E Hynds, Vitor H Teixeira, Muzlifah Haniffa, Kyungtae Lim, Dawei Sun, Emma L Rawlins, Amanda J Oliver, Paul A Lyons, John C Marioni, Christiana Ruhrberg, Zewen Kelvin Tuong, Menna R Clatworthy, James L Reading, Sam M Janes, Sarah A Teichmann, Kerstin B Meyer, Marko Z Nikolić
Studies of human lung development have focused on epithelial and mesenchymal cell types and function, but much less is known about the developing lung immune cells, even though the airways are a major site of mucosal immunity after birth. An unanswered question is whether tissue-resident immune cells play a role in shaping the tissue as it develops in utero. Here, we profiled human embryonic and fetal lung immune cells using scRNA-seq, smFISH, and immunohistochemistry. At the embryonic stage, we observed an early wave of innate immune cells, including innate lymphoid cells, natural killer cells, myeloid cells, and lineage progenitors...
December 15, 2023: Science Immunology
https://read.qxmd.com/read/38062736/cyclic-stretching-enhances-angiocrine-signals-at-liver-bud-stage-from-hpscs-in-2-dimensional-culture
#12
JOURNAL ARTICLE
Koki Yoshimoto, Koichiro Maki, Taiji Adachi, Ken-Ichiro Kamei
Angiocrine signals during the development and growth of organs, including the liver, intestine, lung, and bone, are essential components of intercellular communication. The signals elicited during the liver bud stage are critical for vascularization and enhanced during the intercellular communication between the cells negative for KDR (KDR- cells) and the cells positive for KDR (KDR+ cells), which constitute the liver bud. However, the use of a human pluripotent stem cell (hPSC)-derived system has not facilitated the generation of a perfusable vascularized liver organoid that allows elucidation of liver development and has great potential for liver transplantation...
December 7, 2023: Tissue Engineering. Part A
https://read.qxmd.com/read/37981587/characterization-of-the-congenital-diaphragmatic-hernia-model-in-c57bl-6j-fetal-mice-a-step-toward-lineage-tracing-experiments
#13
JOURNAL ARTICLE
Fabian Doktor, Rebeca Lopes Figueira, Kasra Khalaj, Aizah Ijaz, Martin Lacher, Matisse Blundell, Lina Antounians, Augusto Zani
PURPOSE: Lineage tracing is key to study the fate of individual cells and their progeny especially in developmental biology. To conduct these studies, we aimed to establish a reproducible model of CDH in the most commonly used genetic background strain that is C57BL/6J mice. METHODS: CDH was induced in C57BL/6J dams by maternal administration of nitrofen + bisdiamine at E8.5. Fetuses from olive oil-gavaged mothers served as controls. Lungs from CDH and control fetuses were compared for (1) growth via radial airspace count (RAC), mean linear intercept (MLI) and gene expression for Fgf10, Nrp1, and Ctnnb1; (2) maturation (Pdpn, Spc, Ager, Abca3, Eln, Acta2, Pdgfra) via gene and protein expression; (3) vascularization via gene and protein expression (CD31, Vegfa, Vegfr1/2, Epas1, Enos)...
November 20, 2023: Pediatric Surgery International
https://read.qxmd.com/read/37937267/association-between-maternal-neuraxial-analgesia-and-neonatal-outcomes-in-very-preterm-infants
#14
JOURNAL ARTICLE
Lilly Y Liu, Elizabeth M S Lange, Lynn M Yee
Background  Although the use of neuraxial analgesia has been shown to improve uteroplacental blood flow and maternal and fetal hemodynamics related to labor pain, possibly improving immediate outcomes in term neonates, the association between neuraxial analgesia use and outcomes in preterm neonates remains unclear. Objective  The aim of this article was to evaluate the association between maternal use of neuraxial analgesia and neonatal outcomes in very preterm infants. Methods  This is a retrospective cohort study of women delivering singleton neonates between 23 and 32 weeks' gestation at a large academic center between 2012 and 2016...
July 2023: American Journal of Perinatology Reports
https://read.qxmd.com/read/37831972/progressive-multiple-organ-dysfunction-syndrome-in-adolescent-pregnancy-case-report
#15
JOURNAL ARTICLE
Jennifer Rodrigues Boock, Alexis Strickler, María Teresa Silva Elgueta, Loreto Twele Montecinos, Carolina Lizama Deluchi
INTRODUCTION: Adolescent pregnancy is a physiological process, but it can evolve with premature delivery, severe obstetric or clinical pathologies, mortality, or sequelae for mother and child. We aim to report the progressive multiple organ dysfunction syndrome secondary to pyelonephritis and sepsis during prepartum, delivery, and puerperium of adolescent pregnancy and its sequelae. CASE REPORT: A 14-year-old adolescent with a pregnancy of 27 weeks of gestation controlled from 8 to 25 weeks...
October 13, 2023: Medwave
https://read.qxmd.com/read/37807588/figo-good-practice-recommendations-for-preterm-labor-and-preterm-prelabor-rupture-of-membranes-prep-for-labor-triage-to-minimize-risks-and-maximize-favorable-outcomes
#16
JOURNAL ARTICLE
Akaninyene Eseme Ubom, Manu Vatish, Eytan R Barnea
Preterm labor occurs in around 10% of pregnancies worldwide. Once diagnosed, significant efforts must be made to reduce the likelihood of morbidity and mortality associated with preterm birth. In high-resource settings, access to hospitals with a neonatal intensive care unit (NICU) is readily available, whereas access to NICU care is limited in low- and middle-income countries (LMICs) and many rural settings. Use of FIGO's Prep-for-Labor triage method rapidly identifies low- and high-risk patients with preterm labor to enable clinicians to decide whether the patient can be managed on site or if transfer to a level II-IV facility is needed...
October 2023: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/37769696/neonatal-hypoglycemia-following-late-preterm-antenatal-corticosteroid-administration-in-individuals-with-diabetes-in-pregnancy
#17
JOURNAL ARTICLE
Natasha Raj-Derouin, John M Perino, Sophie Fisher, Yijia Zhang, Vidhu Thaker, Noelia M Zork
OBJECTIVE:  Antenatal corticosteroid (ACS) administration is standard practice for pregnant individuals delivering in the late preterm period, though no guidelines are in place for those with diabetes. This study aims to characterize the prevalence of neonatal hypoglycemia after ACS administration in pregnant individuals with diabetes delivering in the late preterm period. STUDY DESIGN:  This is a retrospective, single-center, case-control study of individuals with diabetes who delivered between 340/7 and 366/7 weeks' gestation at a large academic medical center from 2016 to 2021...
November 10, 2023: American Journal of Perinatology
https://read.qxmd.com/read/37744680/lung-regeneration-with-rat-fetal-lung-implantation-and-promotion-of-alveolar-stem-cell-differentiation-by-corticosteroids
#18
JOURNAL ARTICLE
Daisuke Matsumoto, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama, Shinichi Sakamoto, Mika Takashima, Naoya Kawakita, Hiromitsu Takizawa
INTRODUCTION: The lung is a difficult organ to regenerate, and the development of functional lungs has still not been achieved. In this study, we investigated lung regeneration using a rat fetal lung tissue-implanted model. This study aimed to evaluate the functioning of the implanted fetal lung tissue and investigate the graft differentiation and maturation mechanism, focusing on alveolar stem cells. METHODS: Fetal lung tissue fragments were obtained from Lewis rats on day 17 and implanted into adult lungs...
December 2023: Regenerative Therapy
https://read.qxmd.com/read/37743742/artificial-placenta-technology-history-potential-and-perception
#19
REVIEW
H Usuda, S Watanabe, Hanita T, M Saito, S Sato, H Ikeda, Y Kumagai, M C Choolani, M W Kemp
As presently conceptualised, the artificial placenta (AP) is an experimental life support platform for extremely preterm infants (i.e. 400-600 g; 21-23+6 weeks of gestation) born at the border of viability. It is based around the oxygenation of the periviable fetus using gas-exchangers connected to the fetal vasculature. In this system, the lung remains fluid-filled and the fetus remains in a quiescent state. The AP has been in development for some sixty years. Over this time, animal experimental models have evolved iteratively from employing external pump-driven systems used to support comparatively mature fetuses (generally goats or sheep) to platforms driven by the fetal heart and used successfully to maintain extremely premature fetuses weighing around 600 g...
September 26, 2023: Placenta
https://read.qxmd.com/read/37697929/respiratory-benefit-in-preterm-lambs-is-progressively-lost-when-the-concentration-of-fetal-plasma-betamethasone-is-titrated-below-two-nanograms-per-milliliter
#20
JOURNAL ARTICLE
Erin L Fee, Tsukasa Takahashi, Yuki Takahashi, Sean W D Carter, Michael W Clarke, Mark A Milad, Haruo Usuda, Hideyuki Ikeda, Yusaku Kumagai, Yuya Saito, Demelza J Ireland, John P Newnham, Masatoshi Saito, Alan H Jobe, Matthew W Kemp
Background : Antenatal steroid therapy is standard of care for women at imminent risk of preterm delivery. Current dosing regimens employ supra-pharmacological doses to achieve extended fetal steroid exposures. Objective : We aimed to determine the lowest fetal plasma betamethasone concentration sufficient to achieve functional preterm lung maturation. Study design : Ewes with singles fetuses underwent surgery to install a fetal jugular catheter. Adopting a step-wise design, ewes were randomised to either a saline-only group (Negative Control Group; n=9), or one of four betamethasone-treatment groups...
September 12, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology
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