Josephine L Barnes, Masahiro Yoshida, Peng He, Kaylee B Worlock, Rik G H Lindeboom, Chenqu Suo, J Patrick Pett, Anna Wilbrey-Clark, Emma Dann, Lira Mamanova, Laura Richardson, Krzysztof Polanski, Adam Pennycuick, Jessica Allen-Hyttinen, Iván T Herczeg, Romina Arzili, Robert E Hynds, Vitor H Teixeira, Muzlifah Haniffa, Kyungtae Lim, Dawei Sun, Emma L Rawlins, Amanda J Oliver, Paul A Lyons, John C Marioni, Christiana Ruhrberg, Zewen Kelvin Tuong, Menna R Clatworthy, James L Reading, Sam M Janes, Sarah A Teichmann, Kerstin B Meyer, Marko Z Nikolić
Studies of human lung development have focused on epithelial and mesenchymal cell types and function, but much less is known about the developing lung immune cells, even though the airways are a major site of mucosal immunity after birth. An unanswered question is whether tissue-resident immune cells play a role in shaping the tissue as it develops in utero. Here, we profiled human embryonic and fetal lung immune cells using scRNA-seq, smFISH, and immunohistochemistry. At the embryonic stage, we observed an early wave of innate immune cells, including innate lymphoid cells, natural killer cells, myeloid cells, and lineage progenitors...
December 15, 2023: Science Immunology