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Fosfomycin

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https://www.readbyqxmd.com/read/28427111/-in-vitro-activity-of-mecillinam-against-urine-isolates-of-escherichia-coli-from-outpatient-departments-in-germany
#1
Michael Kresken, Barbara Körber-Irrgang, Kurt G Naber
National and international guidelines recommend fosfomycin trometamol, nitrofurantoin, nitroxoline, and pivmecillinam as first-line agents for the treatment of acute uncomplicated cystitis. Escherichia coli is by far the leading cause of community-acquired urinary tract infections. Pivmecillinam (X-SYSTO(®)) is an oral prodrug of mecillinam, a penicillin derivative that was reintroduced to the German market in March 2016. This study aimed to investigate the proportion of mecillinam-resistant strains among E...
April 20, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28409871/a-molecular-docking-and-dynamics-approach-to-screen-potent-inhibitors-against-fosfomycin-resistant-enzyme-in-clinical-klebsiella-pneumoniae
#2
D Thirumal Kumar, P Lavanya, C George Priya Doss, Iftikhar Aslam Tayubi, D R Naveen Kumar, I Francis Yesurajan, R Siva, V Balaji
Klebsiella pneumoniae, BA6753 was cultured from a patient in the Clinical Microbiology Laboratory of Christian Medical College. K. pneumoniae, BA6753 has a multidrug resistance plasmid encoding novel FosA variant-7, fosfomycin resistance enzyme. Minimal side effects and a wide range of bactericidal activity of fosfomycin have resulted in its expanded clinical use that prompts the rise of fosfomycin-resistant strains. At present, there are no effective inhibitors available to conflict the FosA-medicated fosfomycin resistance...
April 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28400021/east-and-west-african-milk-products-are-reservoirs-for-human-and-livestock-associated-staphylococcus-aureus
#3
Christoph Jans, Axel Merz, Sophia Johler, Mario Younan, Sabine A Tanner, Dasel Wambua Mulwa Kaindi, John Wangoh, Bassirou Bonfoh, Leo Meile, Taurai Tasara
Staphylococcus aureus frequently isolated from milk products in sub-Saharan Africa (SSA) is a major pathogen responsible for food intoxication, human and animal diseases. SSA hospital-derived strains are well studied but data on the population structure of foodborne S. aureus required to identify possible staphylococcal food poisoning sources is lacking. Therefore, the aim was to assess the population genetic structure, virulence and antibiotic resistance genes associated with milk-derived S. aureus isolates from Côte d'Ivoire, Kenya and Somalia through spa-typing, MLST, and DNA microarray analysis...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28396549/in-vivo-pharmacokinetics-and-pharmacodynamics-of-zti-01-fosfomycin-for-injection-in-the-neutropenic-murine-thigh-infection-model-against-e-coli-k-pneumoniae-and-p-aeruginosa
#4
Alexander J Lepak, Miao Zhao, Brian VanScoy, Daniel S Taylor, Evelyn Ellis-Grosse, Paul G Ambrose, David R Andes
Fosfomycin is a broad-spectrum agent with activity against gram-positive and gram-negative bacteria, including drug-resistant strains, such as extended spectrum beta-lactamase (ESBL)-producing and carbapenem-resistant (CR) gram-negative rods. In the present study, the pharmacokinetic/pharmacodynamic (PK/PD) activity of ZTI-01 (fosfomycin for injection) was evaluated in the neutropenic murine thigh infection model against 5 E. coli (EC), 3 K. pneumoniae (KPN), and 2 P. aeruginosa (PSA) strains, including a subset with ESBL and CR phenotype...
April 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28390962/in-vitro-activity-of-fosfomycin-trometamol-and-other-oral-antibiotics-against-multi-drug-resistant-uropathogens
#5
Maria Lina Mezzatesta, Giulia La Rosa, Gaetano Maugeri, Tiziana Zingali, Carla Caio, Andrea Novelli, Stefania Stefani
Clinical midstream and urinary catheter isolates (n=106) of extended-spectrum β-lactamase (ESBL)-positive Escherichia coli, carbapenemase-producing Klebsiella pneumoniae, Proteus mirabilis and meticillin-resistant Staphylococcus saprophyticus were tested against fosfomycin using the agar dilution method, the broth microdilution method and the gradient test described by the Clinical and Laboratory Standards Institute. Nitrofurantoin, co-trimoxazole, amoxicillin/clavulanic acid, cefuroxime, levofloxacin and ciprofloxacin were tested using the gradient test alone...
April 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28384863/comparative-evaluation-of-fosfomycin-activity-with-other-antimicrobial-agents-against-e-coli-isolates-from-urinary-tract-infections
#6
Ahmed Sardar, Sreekanth Reddy Basireddy, Anwar Navaz, Manisha Singh, Vasanti Kabra
INTRODUCTION: Fosfomycin is a broad spectrum anti-microbial agent with activity against various bacterial agents. It is a bactericidal antibiotic which interferes with cell wall synthesis. Fosfomycin is rapidly absorbed orally and majority of the drug is excreted unchanged in urine with very high concentration levels achieved in urine after a single oral dose. Urine levels remain high for prolonged period which makes it a suitable drug in the treatment of Urinary Tract Infections (UTI)...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28379732/prevalence-of-plasmid-mediated-fosfomycin-resistance-gene-fosa3-among-ctx-m-producing-escherichia-coli-isolates-from-chickens-in-china
#7
Wei Jiang, Shuai Men, Linghan Kong, Suzhen Ma, Yongqiang Yang, Yongxiang Wang, Qiwu Yuan, Guangyang Cheng, Wencheng Zou, Hongning Wang
The aim of this study was to investigate the prevalence of fosfomycin resistance gene fosA3 and characterize plasmids harboring fosA3 among CTX-M-producing Escherichia coli from chickens in China. A total of 234 CTX-M-producing E. coli isolates collected from chickens from 2014 to 2016 were screened for the presence of plasmid-mediated fosfomycin resistance genes (fosA, fosA3, and fosC2). Clonal relatedness of fosA3-positive isolates was determined by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST)...
April 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28377752/antimicrobial-resistance-and-molecular-characterization-of-staphylococcus-aureus-causing-childhood-pneumonia-in-shanghai
#8
Zhen Song, Fei-Fei Gu, Xiao-Kui Guo, Yu-Xing Ni, Ping He, Li-Zhong Han
Staphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen causing pneumonia among children. To estimate the prevalence and molecular properties of S. aureus in children pneumonia in Shanghai, China, 107 hospitalized children with S. aureus pneumonia from two children's hospitals from January 2014 through June 2015 were studied. S. aureus isolates from the respiratory specimens were characterized by antimicrobial susceptibility, agr typing, toxin genes, multilocus sequence typing (MLST), spa, and SCCmec typing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28367887/antimicrobial-resistance-of-pseudomonas-aeruginosa-isolated-from-dogs-and-cats-in-primary-veterinary-hospitals-in-japan
#9
Shoichiro Yukawa, Yuzo Tsuyuki, Tomomi Sato, Akira Fukuda, Masaru Usui, Yutaka Tamura
To investigate antimicrobial resistance, 200 Pseudomonas aeruginosa isolates were collected from dogs and cats in primary veterinary hospitals in Japan. Resistance rates against ciprofloxacin, cefotaxime, gentamicin, amikacin, and fosfomycin were 9, 12.5, 4.5, 2.5, and 35.5%, respectively. One strain (0.5%) displayed resistance to ceftazidime. We did not detect any strain resistant to imipenem nor any multidrug-resistant P. aeruginosa as defined by the Law Concerning the Prevention of Infections and Medical Care for Patients with Infections of the Japanese Ministry of Health, Labour, and Welfare...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28360903/cooperative-actions-of-crp-camp-and-fnr-increase-the-fosfomycin-susceptibility-of-enterohaemorrhagic-escherichia-coli-ehec-by-elevating-the-expression-of-glpt-and-uhpt-under-anaerobic-conditions
#10
Kumiko Kurabayashi, Koichi Tanimoto, Haruyoshi Tomita, Hidetada Hirakawa
Bacterial infections to anaerobic site are often hard to be treated because the activity of most of antimicrobials decreases under anaerobic conditions. However, fosfomycin rather provides a greater activity under anaerobic conditions than aerobic conditions. Previously, we found that expression of glpT and uhpT, fosfomycin symporters in enterohaemorrhagic Escherichia coli (EHEC) was upregulated by FNR, a global regulator during the anaerobiosis of the bacterium, which led to increased uptake and susceptibility to this drug...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28360153/whole-genome-sequence-and-fosfomycin-resistance-of-bacillus-sp-strain-g3-2015-isolated-from-seawater-off-the-coast-of-malaysia
#11
Xin-Yue Chan, Jian-Woon Chen, Tan-Guan-Sheng Adrian, Kar-Wai Hong, Chien-Yi Chang, Wai-Fong Yin, Kok-Gan Chan
Bacillus sp. is a Gram-positive bacterium that is commonly found in seawater. In this study, the genome of marine Bacillus sp. strain G3(2015) was sequenced using MiSeq. The fosfomycin resistant gene fosB was identified upon bacterial genome annotation.
March 30, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28352915/towards-the-biodegradation-pathway-of-fosfomycin
#12
K Pallitsch, A Schweifer, A Roller, F Hammerschmidt
Three functionalised propylphosphonic acids were synthesised to study C-P bond cleavage in R. huakuii PMY1. (R)-1-Hydroxy-2-oxopropylphosphonic acid [(R)-5] was prepared by chiral resolution of (±)-dimethyl 1-hydroxy-2-methylallyllphosphonate [(±)-12], followed by ozonolysis and deprotection. The N-(l-alanyl)-substituted (1R,2R)-2-amino-1-hydroxypropylphosphonic acid 10, a potential precursor for 2-oxopropylphosphonic acid (5) in cells, was obtained by coupling the aminophosphonic acid with benzotriazole-activated Z-l-alanine and hydrogenolytic deprotection...
April 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28351914/the-n-acetylmuramic-acid-6-phosphate-phosphatase-mupp-completes-the-pseudomonas-peptidoglycan-recycling-pathway-leading-to-intrinsic-fosfomycin-resistance
#13
Marina Borisova, Jonathan Gisin, Christoph Mayer
Bacterial cells are encased in and stabilized by a netlike peptidoglycan (PGN) cell wall that undergoes turnover during bacterial growth. PGN turnover fragments are frequently salvaged by the cells via a pathway referred to as PGN recycling. Two different routes for the recycling of the cell wall sugar N-acetylmuramic acid (MurNAc) have been recognized in bacteria. In Escherichia coli and related enterobacteria, as well as in most Gram-positive bacteria, MurNAc is recovered via a catabolic route requiring a MurNAc 6-phosphate etherase (MurQ in E...
March 28, 2017: MBio
https://www.readbyqxmd.com/read/28350901/gram-negative-bacterial-infections-research-priorities-accomplishments-and-future-directions-of-the-antibacterial-resistance-leadership-group
#14
Yohei Doi, Robert A Bonomo, David C Hooper, Keith S Kaye, James R Johnson, Cornelius J Clancy, Joshua T Thaden, Martin E Stryjewski, David van Duin
Antimicrobial resistance in pathogenic gram-negative bacteria is one of the most pressing challenges in the field of infectious diseases and is one of 4 key areas of unmet medical need identified by the Antibacterial Resistance Leadership Group (ARLG). The mission of the Gram-Negative Committee is to advance our knowledge of these challenging infections and implement studies to improve patient outcomes. Studies have fallen primarily into 2 broad categories: prospective cohort studies and interventional trials...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28350183/prevalence-and-antimicrobial-susceptibility-of-enterobacteriaceae-isolated-from-retail-pepper-in-vietnam
#15
Tetsuya Harada, Ryoko Yamane, Van Chinh Dang, Do Phuc Nguyen, Thi Anh Dao Nguyen, Michio Jinnai, Shinya Yonogi, Ryuji Kawahara, Masashi Kanki, Takao Kawai, Kentaro Kawatsu, Yuko Kumeda, Yuji Isegawa, Yoshimasa Yamamoto
To investigate the microbial quality of retail pepper in Vietnam, the enumeration and detection of Enterobacteriaceae and the screening of cefotaxime (CTX)-resistant coliforms were performed by using 84 commercial samples. Although Enterobacteriaceae were isolated from 78 samples, the number of Enterobacteriaceae was lower than 1.0 log CFU/g in 46 samples. For the detection of Enterobacteriaceae with the International Organization for Standardization methods, Salmonella spp., Escherichia coli , Klebsiella pneumoniae , Cronobacter sakazakii , and Enterobacter cloacae complex were isolated from 5, 12, 36, 19, and 30 samples, respectively...
March 28, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28332345/high-incidence-of-virulence-factors-among-clinical-enterococcus-faecalis-isolates-in-southwestern-iran
#16
Hamid Heidari, Somayeh Hasanpour, Hadi Sedigh Ebrahim-Saraie, Mohammad Motamedifar
BACKGROUND: Over the past two decades, enterococci have emerged as an important agent responsible for hospital acquired infection. Several virulence factors contribute to the adherence, colonization, evasion of the host immune response, and pathogenicity and severity of the infection. Enterococcus faecalis is the most common and virulent species causing infections in hospitalized patients. The aim of the present study was to examine the prevalence of genes encoding virulence factors and antimicrobial resistance patterns of E...
March 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28320719/antibiotic-effects-on-methicillin-resistant-staphylococcus-aureus-cytoplasmic-peptidoglycan-intermediate-levels-evidence-for-potential-metabolite-level-regulatory-loops
#17
Harika Vemula, Navid J Ayon, Alloch Burton, William G Gutheil
Cytoplasmic peptidoglycan (PG) precursor levels were determined in methicillin resistant S. aureus (MRSA) after exposure to several cell wall targeting antibiotics. Three experiments were performed: 1) Exposure to 4x MIC levels (acute). 2) Exposure to sub-MIC levels (sub-acute). 3) A time course of the effect of vancomycin. In acute exposure experiments, fosfomycin increased UDP-GlcNAc, as expected, and resulted in substantially lower levels of total UDP-linked metabolite accumulation relative to other pathway inhibitors, indicating reduced entry into this pathway...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28316632/cost-effectiveness-analysis-of-fosfomycin-for-treatment-of-uncomplicated-urinary-tract-infections-in-ontario
#18
Louise Perrault, Sybil Dahan, Ange Christelle Iliza, Jacques LeLorier, George G Zhanel
Background and Objective. Bacterial resistance to antibiotics traditionally used to treat uncomplicated urinary tract infections (uUTIs) is rising in Canada. We compared the cost-per-patient in Ontario of including fosfomycin (an antibiotic with a low resistance profile) as an option for first-line empirical treatment of uUTIs with current cost of treatment with sulfonamides, fluoroquinolones, and nitrofurantoin. Methods. A decision-tree model was used to perform a cost-minimization analysis. All possible outcomes of a uUTI caused by bacterial species treated with either sulfonamides, fluoroquinolones, nitrofurantoin, or fosfomycin were included...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28306563/antimicrobial-resistant-gram-negative-infections-in-neonates-burden-of-disease-and-challenges-in-treatment
#19
Laura Folgori, Julia Bielicki, Paul T Heath, Mike Sharland
PURPOSE OF REVIEW: This review summarizes the main challenges of antimicrobial resistance (AMR) in the neonatal population with a special focus on multidrug-resistant (MDR) Gram-negative pathogens. RECENT FINDINGS: MDR-Gram-negative bacteria are a great concern in the neonatal population, with a worldwide rise in the reported incidence and with very limited therapeutic options. Extended-spectrum β-lactamase and carbapenem-resistant Enterobacteriaceae (CRE) have been reported as responsible for neonatal ICU outbreaks...
March 16, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28302074/clonality-outer-membrane-proteins-profile-and-efflux-pump-in-kpc-producing-enterobacter-sp-in-brazil
#20
Juliana Ferraz Rosa, Camila Rizek, Ana Paula Marchi, Thais Guimaraes, Lourdes Miranda, Claudia Carrilho, Anna S Levin, Silvia F Costa
BACKGROUND: Carbapenems resistance in Enterobacter spp. has increased in the last decade, few studies, however, described the mechanisms of resistance in this bacterium. This study evaluated clonality and mechanisms of carbapenems resistance in clinical isolates of Enterobacter spp. identified in three hospitals in Brazil (Hospital A, B and C) over 7-year. METHODS: Antibiotics sensitivity, pulsed-field gel electrophoresis (PFGE), PCR for carbapenemase and efflux pump genes were performed for all carbapenems-resistant isolates...
March 17, 2017: BMC Microbiology
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