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https://www.readbyqxmd.com/read/27909700/dataset-for-a-dugesia-japonica-de-novo-transcriptome-assembly-utilized-for-defining-the-voltage-gated-like-ion-channel-superfamily
#1
John D Chan, Dan Zhang, Xiaolong Liu, Magdalena Z Zarowiecki, Matthew Berriman, Jonathan S Marchant
This data article provides a transcriptomic resource for the free living planarian flatworm Dugesia japonica related to the research article entitled 'Utilizing the planarian voltage-gated ion channel transcriptome to resolve a role for a Ca(2+) channel in neuromuscular function and regeneration (J.D. Chan, D. Zhang, X. Liu, M. Zarowiecki, M. Berriman, J.S. Marchant, 2016) [1]. Data provided in this submission comprise sequence information for the unfiltered de novo assembly, the filtered assembly and a curated analysis of voltage-gated like (VGL) ion channel sequences mined from this resource...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27871925/identification-and-characterization-of-a-phospholipid-scramblase-encoded-by-planarian-dugesia-japonica
#2
Yu Han, Ao Li, Lili Gao, Weiwei Wu, Hongkuan Deng, Wenjing Hu, Na Li, Shimin Sun, Xiufang Zhang, Bosheng Zhao, Baohua Liu, Qiuxiang Pang
Phospholipid scramblases (PLSCRs) are the conserved calcium-binding, type II transmembrane proteins synthesized in all eukaryotic organisms. In mammals, these proteins play essential roles in various physiological processes, especially in the immune responses. However, the existence of PLSCRs and their biological functions in planarian are still unknown at present. In this study, a new member of PLSCRs was identified in planarian Dugesia japonica (D. japonica), named DjPLSCR. The sequence analysis revealed that it contains an opening reading frame consisting of 897bp encoding a putative protein of 241 amino acids with a predicted molecular mass of ~28...
November 18, 2016: Gene
https://www.readbyqxmd.com/read/27864883/neuronal-sources-of-hedgehog-modulate-neurogenesis-in-the-adult-planarian-brain
#3
Ko W Currie, Alyssa M Molinaro, Bret J Pearson
The asexual freshwater planarian is a constitutive adult, whose central nervous system (CNS) is in a state of constant homeostatic neurogenesis. However, very little is known about the extrinsic signals that act on planarian stem cells to modulate rates of neurogenesis. We have identified two planarian homeobox transcription factors, Smed-nkx2.1 and Smed-arx, which are required for the maintenance of cholinergic, GABAergic, and octopaminergic neurons in the planarian CNS. These very same neurons also produce the planarian hedgehog ligand (Smed-hh), which appears to communicate with brain-adjacent stem cells to promote normal levels of neurogenesis...
November 19, 2016: ELife
https://www.readbyqxmd.com/read/27845240/behavioral-effects-of-splenda-equal-and-sucrose-clues-from-planarians-on-sweeteners
#4
Kevin Ouyang, Sunil Nayak, Young Lee, Erin Kim, Michael Wu, Christopher S Tallarida, Scott M Rawls
Sweetened diets share commonalities with drugs of abuse, but studies comparing behavioral effects of different sweeteners are lacking. Common table sugar produces rewarding and withdrawal effects in planarians. We postulated that Splenda and Equal would produce similar responses and used a tetrad of behavioral assays to test this hypothesis. Acute exposure to a relatively high concentration (10%) of each sweetener produced stereotyped responses (C-shapes) and reduced motility, with Equal producing greater motor effects than sucrose or Splenda...
November 11, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27801429/regulatory-rnas-in-planarians
#5
Kamila Pawlicka, Patrick M Perrigue
The full scope of regulatory RNA evolution and function in epigenetic processes is still not well understood. The development of planarian flatworms to be used as a simple model organism for research has shown a great potential to address gaps in the knowledge in this field of study. The genomes of planarians encode a wide array of regulatory RNAs that function in gene regulation. Here, we review planarians as a suitable model organism for the identification and function of regulatory RNAs.
November 2, 2016: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/27800171/temporal-regulation-of-planarian-eye-regeneration
#6
Michelle E Deochand, Taylor R Birkholz, Wendy S Beane
While tissue regeneration is typically studied using standard injury models, in nature injuries vary greatly in the amount and location of tissues lost. Planarians have the unique ability to regenerate from many different injuries (including from tiny fragments with no brain), allowing us to study the effects of different injuries on regeneration timelines. We followed the timing of regeneration for one organ, the eye, after multiple injury types that involved tissue loss (single- and double-eye ablation, and decapitation) in Schmidtea mediterranea...
August 2016: Regeneration
https://www.readbyqxmd.com/read/27771293/utilizing-the-planarian-voltage-gated-ion-channel-transcriptome-to-resolve-a-role-for-a-ca-2-channel-in-neuromuscular-function-and-regeneration
#7
John D Chan, Dan Zhang, Xiaolong Liu, Magdalena Zarowiecki, Matthew Berriman, Jonathan S Marchant
The robust regenerative capacity of planarian flatworms depends on the orchestration of signaling events from early wounding responses through the stem cell enacted differentiative outcomes that restore appropriate tissue types. Acute signaling events in excitable cells play an important role in determining regenerative polarity, rationalized by the discovery that sub-epidermal muscle cells express critical patterning genes known to control regenerative outcomes. These data imply a dual conductive (neuromuscular signaling) and instructive (anterior-posterior patterning) role for Ca(2+) signaling in planarian regeneration...
October 19, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27737903/localization-of-planarian-%C3%AE-catenin-1-reveals-multiple-roles-during-anterior-posterior-regeneration-and-organogenesis
#8
Miquel Sureda-Gómez, José M Martín-Durán, Teresa Adell
The β-catenin-dependent Wnt pathway exerts multiple context-dependent roles in embryonic and adult tissues. In planarians, β-catenin-1 is thought to specify posterior identities through the generation of an anteroposterior gradient. However, the existence of such a gradient has not been directly demonstrated. Here, we use a specific polyclonal antibody to demonstrate that nuclear β-CATENIN-1 exists as an anteroposterior gradient from the pre-pharyngeal region to the tail of the planarian Schmidtea polychroa High levels in the posterior region steadily decrease towards the pre-pharyngeal region but then increase again in the head region...
November 15, 2016: Development
https://www.readbyqxmd.com/read/27628751/photokinesis-and-djopsin-gene-expression-analysis-during-the-regeneration-of-planarian-eyes
#9
Zimei Dong, Yanqing Yuwen, Yingxu Sima, Yanping Dong, Huina Zhan, Guangwen Chen, Dezeng Liu
Planarians are the ideal models for studying eye development with the simple eye structure and exceptionally rapid regeneration. Here, we observed the eye morphogenesis, photophobic behavior, spectral sensitivity, and expression pattern of Djopsin in planarian Dugesia japonica. The results showed that: (1) Djopsin encoding the putative protein belonged to rhabdomeric opsins group and displayed a high conservation during animal evolution; (2) planarians displayed diverse photophobic response to different visible wavelength and were more sensitive to the light blue (495 nm) and yellow (635 nm); (3) the morphogenesis and functional recovery of eyes were related to the expression pattern of Djopsin during head regeneration; (4) Djopsin gene plays a major role in functional recovery during eyes regeneration and visual system maintenance in adult planarians...
September 14, 2016: Integrative Zoology
https://www.readbyqxmd.com/read/27616704/cotinine-antagonizes-the-behavioral-effects-of-nicotine-exposure-in-the-planarian-girardia-tigrina
#10
Daniel J Bach, Matthew Tenaglia, Debra L Baker, Sean Deats, Erica Montgomery, Oné R Pagán
Nicotine is one of the most addictive drugs abused by humans. Our laboratory and others have demonstrated that nicotine decreases motility and induces seizure-like behavior in planarians (pSLM, which are vigorous writhing and bending of the body) in a concentration-dependent manner. Nicotine also induces withdrawal-like behaviors in these worms. Cotinine is the major nicotine metabolite in humans, although it is not the final product of nicotine metabolism. Cotinine is mostly inactive in vertebrate nervous systems and is currently being explored as a molecule which possess most of nicotine's beneficial effects and few of its undesirable ones...
October 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27612384/a-functional-genomics-screen-in-planarians-reveals-regulators-of-whole-brain-regeneration
#11
Rachel H Roberts-Galbraith, John L Brubacher, Phillip A Newmark
Planarians regenerate all body parts after injury, including the central nervous system (CNS). We capitalized on this distinctive trait and completed a gene expression-guided functional screen to identify factors that regulate diverse aspects of neural regeneration in Schmidtea mediterranea. Our screen revealed molecules that influence neural cell fates, support the formation of a major connective hub, and promote reestablishment of chemosensory behavior. We also identified genes that encode signaling molecules with roles in head regeneration, including some that are produced in a previously uncharacterized parenchymal population of cells...
September 9, 2016: ELife
https://www.readbyqxmd.com/read/27612382/hedgehog-signaling-regulates-gene-expression-in-planarian-glia
#12
Irving E Wang, Sylvain W Lapan, M Lucila Scimone, Thomas R Clandinin, Peter W Reddien
Hedgehog signaling is critical for vertebrate central nervous system (CNS) development, but its role in CNS biology in other organisms is poorly characterized. In the planarian Schmidtea mediterranea, hedgehog (hh) is expressed in medial cephalic ganglia neurons, suggesting a possible role in CNS maintenance or regeneration. We performed RNA sequencing of planarian brain tissue following RNAi of hh and patched (ptc), which encodes the Hh receptor. Two misregulated genes, intermediate filament-1 (if-1) and calamari (cali), were expressed in a previously unidentified non-neural CNS cell type...
September 9, 2016: ELife
https://www.readbyqxmd.com/read/27609598/slo1-regulates-ethanol-induced-scrunching-in-freshwater-planarians
#13
Olivier Cochet-Escartin, Jason A Carter, Milena Chakraverti-Wuerthwein, Joydeb Sinha, Eva-Maria S Collins
When freshwater planarians are exposed to a low-percentage (0.5%-1%) alcohol solution, they display a characteristic 'drunken' phenotype. Here we show that this drunken phenotype is a mixture of cilia-mediated gliding and scrunching, a muscular-based planarian gait which we recently demonstrated to be triggered by adverse environmental stimuli. At exogenous ethanol concentrations ≥2% (v/v), planarians become gradually immobilized and ultimately die. Using RNA interference (RNAi) for targeted gene knockdown, we elucidate the molecular basis for ethanol sensing and show that the big potassium ion channel SLO1 is necessary for ethanol sensitivity in planarians...
2016: Physical Biology
https://www.readbyqxmd.com/read/27606067/the-nurd-complex-component-p66-suppresses-photoreceptor-neuron-regeneration-in-planarians
#14
Constanza Vásquez-Doorman, Christian P Petersen
Regeneration involves precise control of cell fate to produce an appropriate complement of tissues formed within a blastema. Several chromatin-modifying complexes have been identified as required for regeneration in planarians, but it is unclear whether this class of molecules uniformly promotes the production of differentiated cells. We identify a function for p66, encoding a DNA-binding protein component of the NuRD (nucleosome remodeling and deacetylase) complex, as well as the chromodomain helicase chd4, in suppressing production of photoreceptor neurons (PRNs) in planarians...
June 2016: Regeneration
https://www.readbyqxmd.com/read/27606065/go-ahead-grow-a-head-a-planarian-s-guide-to-anterior-regeneration
#15
REVIEW
Suthira Owlarn, Kerstin Bartscherer
The unique ability of some planarian species to regenerate a head de novo, including a functional brain, provides an experimentally accessible system in which to study the mechanisms underlying regeneration. Here, we summarize the current knowledge on the key steps of planarian head regeneration (head-versus-tail decision, anterior pole formation and head patterning) and their molecular and cellular basis. Moreover, instructive properties of the anterior pole as a putative organizer and in coordinating anterior midline formation are discussed...
June 2016: Regeneration
https://www.readbyqxmd.com/read/27589778/occurrence-of-the-toxin-producing-aspergillus-versicolor-tiraboschi-in-residential-buildings
#16
Marlena Piontek, Katarzyna Łuszczyńska, Hanna Lechów
In an area representative of a moderate climate zone (Lubuskie Province in Poland), mycological tests in over 270 flats demonstrated the occurrence of 82 species of moulds. Aspergillus versicolor Tiraboschi was often encountered on building partitions (frequency 4: frequently). The ability to synthesize the carcinogenic sterigmatocystin (ST) means that it poses a risk to humans and animals. Biotoxicological tests of biomasses of A. versicolor were conducted in the Microbiological and Toxicological Laboratory, using the planarians Dugesia tigrina (Girard)...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27587974/first-report-of-the-genus-cratera-platyhelminthes-geoplanidae-in-argentina-with-description-of-a-new-species-and-comments-on-the-species-of-the-genus
#17
Lisandro Negrete, Francisco Brusa
A new species of land planarians of the genus Cratera is described. Cratera viridimaculata sp. n. was recorded in the Atlantic Forest Ecoregion, in north-eastern Argentina, and represents the first report of the genus Cratera outside Brazil. The new species is about 50 mm in length and externally characterized by a color pattern consisting of a light green olive pigmentation on the dorsum, stippled with dark gray fine spots, and dorsal eyes. Other features regarding the internal anatomy are the presence of a glandular margin, Cutaneous Muscular Index (CMI) of 10-13%, pharynx cylindrical, prostatic vesicle extrabulbar, tubular and C-shaped, with a proximal bifurcated portion, penis papilla protrusible with ejaculatory duct widened in its distal portion, and female atrium funnel-shaped...
2016: ZooKeys
https://www.readbyqxmd.com/read/27573364/genotoxicity-evaluation-of-ionic-liquid-1-octyl-3-methylimidazolium-bromide-in-freshwater-planarian-dugesia-japonica-using-rapd-assay
#18
He-Cai Zhang, Chang-Ying Shi, Hui-Hui Yang, Guang-Wen Chen, De-Zeng Liu
The randomly amplified polymorphic DNA (RAPD) assay has been used to detect DNA alternation and mutation recently. However, the effectiveness of this method in detecting DNA damage in planarians, a model organism for assessing the toxicity of environmental pollutants is unknown. In the present study, RAPD assay was used to detect the DNA damage in planarians treated by the ionic liquid 1-octyl-3-methylimidazolium bromide ([C8mim]Br) for the first time. Among the 20 test RAPD primers, 13 primers with 60-70% GC content produced unique polymorphic band profiles...
August 26, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27565408/the-role-of-a-novel-c-type-lectin-like-protein-from-planarian-in-innate-immunity-and-regeneration
#19
Lili Gao, Yu Han, Hongkuan Deng, Wenjing Hu, Hui Zhen, Na Li, Nianci Qin, Meihui Yan, Weiwei Wu, Baohua Liu, Bosheng Zhao, Qiuxiang Pang
Planarian, a representative of platyhelminthes, has strong regeneration ability and less complicated innate immune system. However, planarian immune system remains poorly understood. In this paper, a novel C-type lectin-like protein, namely, DjCTL was identified and characterized in Dugesia japonica. DjCTL was mainly expressed in the pharyngeal and epidermis and up-regulated upon the induction of lipopolysaccharide (LPS), peptidoglycan (PGN), Gram-positive and Gram-negative bacteria indicating that DjCTL may be involved in the immune responses...
August 23, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27551436/forkhead-containing-transcription-factor-albino-controls-tetrapyrrole-based-body-pigmentation-in-planarian
#20
Chen Wang, Xiao-Shuai Han, Fang-Fang Li, Shuang Huang, Yong-Wen Qin, Xian-Xian Zhao, Qing Jing
Pigmentation processes occur from invertebrates to mammals. Owing to the complexity of the pigmentary system, in vivo animal models for pigmentation study are limited. Planarians are capable of regenerating any missing part including the dark-brown pigments, providing a promising model for pigmentation study. However, the molecular mechanism of planarian body pigmentation is poorly understood. We found in an RNA interference screen that a forkhead containing transcription factor, Albino, was required for pigmentation without affecting survival or other regeneration processes...
2016: Cell Discovery
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