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https://www.readbyqxmd.com/read/29913535/thrombocytopenia-and-platelet-dysfunction-in-acute-tropical-infectious-diseases
#1
Indri Hapsari Putri, Rahajeng N Tunjungputri, Philip G De Groot, Andre J van der Ven, Quirijn de Mast
Thrombocytopenia is a well-known manifestation of acute tropical infectious diseases. The role of platelets in infections has received much attention recently because of their emerging activities in modulation of inflammatory responses, host defense, and vascular integrity. However, while many studies have addressed thrombocytopenia in tropical infections, abnormalities in platelet function have been largely overlooked. This is an important research gap, as platelet dysfunction may contribute to the bleeding tendency that characterizes some tropical infections...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29913527/antimicrobial-and-efflux-inhibitor-activity-of-usnic-acid-against-mycobacterium-abscessus
#2
Ivy B Ramis, Júlia S Vianna, Ana Júlia Reis, Andrea von Groll, Daniela F Ramos, Miguel Viveiros, Pedro E Almeida da Silva
New drugs are needed to treat infections with antimicrobial-resistant Mycobacterium abscessus ; therefore, we evaluated usnic acid as an antimicrobial agent and efflux inhibitor (EI) against M. abscessus . Usnic acid showed antimicrobial activity, and synergistically, the EI verapamil increased this activity. In addition, when we evaluated the interaction of antimicrobials with usnic acid, the increase of their activity was observed. Finally, usnic acid showed an efflux inhibitory effect between the classical EIs verapamil and carbonyl cyanide m-chlorophenylhydrazine...
June 18, 2018: Planta Medica
https://www.readbyqxmd.com/read/29913523/dental-imaging-a-basic-guide-for-the-radiologist
#3
Max Masthoff, Mirjam Gerwing, Malte Masthoff, Maximilian Timme, Johannes Kleinheinz, Markus Berninger, Walter Heindel, Moritz Wildgruber, Christoph Schülke
BACKGROUND:  As dental imaging accounts for approximately 40 % of all X-ray examinations in Germany, profound knowledge of this topic is essential not only for the dentist but also for the clinical radiologist. This review focuses on basic imaging findings regarding the teeth. Therefore, tooth structure, currently available imaging techniques and common findings in conserving dentistry including endodontology, periodontology, implantology and dental trauma are presented. METHODS:  Literature research on the current state of dental radiology was performed using Pubmed...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913479/prioritizing-and-modelling-of-putative-drug-target-proteins-of-candida-albicans-by-systems-biology-approach
#4
Tariq Ismail, Nighat Fatima, Syed Aun Muhammad, Syed Saoud Zaidi, Nisar Rehman, Izhar Hussain, Najam Us Sahr Tariq, Imran Amirzada, Abdul Mannan
Candida albicans (Candida albicans) is one of the major sources of nosocomial infections in humans which may prove fatal in 30% of cases. The hospital acquired infection is very difficult to treat affectively due to the presence of drug resistant pathogenic strains, therefore there is a need to find alternative drug targets to cure this infection. In silico and computational level frame work was used to prioritize and establish antifungal drug targets of Candida albicans. The identification of putative drug targets was based on acquiring 5090 completely annotated genes of Candida albicans from available databases which were categorized into essential and non-essential genes...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913473/meropenem-vaborbactam-vabomere-for-complicated-urinary-tract-infection
#5
(no author information available yet)
No abstract text is available yet for this article.
June 18, 2018: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/29913453/uremic-pruritus-is-associated-with-two-year-cardiovascular-mortality-in-long-term-hemodialysis-patients
#6
Cheng-Hao Weng, Ching-Chih Hu, Tzung-Hai Yen, Ching-Wei Hsu, Wen-Hung Huang
BACKGROUND/AIMS: Uremic pruritus (UP) is an unpleasant complication in patients undergoing maintenance dialysis. Cardiovascular and infection related deaths are the major causes of mortality in patients undergoing dialysis. Studies on the correlation between cardiovascular or infection related mortality and UP are limited. METHODS: We analyze 866 maintenance hemodialysis (MHD) patients in our hemodialysis centers. Clinical parameters and 24-month cardiovascular and infection-related mortality are recorded...
June 15, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29913430/characteristics-and-outcomes-of-laparoscopic-surgery-in-patients-with-large-hiatal-hernia-a-single-center-study
#7
Angela Romano, Davide D'Amore, Giuseppe Esposito, Marianna Petrillo, Modestino Pezzella, Francesco Maria Romano, Giuseppe Izzo, Angelo Cosenza, Francesco Torelli, Antonio Volpicelli, Natale Di Martino
INTRODUCTION: Giant hiatal hernia is characterized by the presence of more than 1/3 of the stomach in the chest, through the diaphragmatic hiatus, with or without other intra-abdominal organs. It is a rare pathology, representing the 5-10% of all hiatal hernias. The advent of laparoscopic surgery led to new surgical techniques, which include the simple reduction with the excision of the hernial sac and the execution of a posterior hiatoplasty, with or without mesh, and the execution of a Collis-Nissen gatroplasty in case of short esophagus...
May 7, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29913325/mucosal-disease-like-lesions-caused-by-hobi-like-pestivirus-in-brazilian-calves-in-2010-2011-clinical-pathological-immunohistochemical-and-virological-characterization
#8
Raquel A S Cruz, Wagner B Rodrigues, Simone Silveira, Victor H S Oliveira, Camila Gonçalves Campos, Ronaldo V Leite Filho, Fabiana M Boabaid, David Driemeier, Cláudio W Canal, Amauri A Alfieri, Caroline A Pescador, Edson M Colodel
A HoBi-like pestivirus was first described in 2004 in a Brazilian fetal bovine serum that was exported to Germany. Nevertheless, it is believed that the virus had been present since the 1990's, when it was detected in buffalos of Brazilian origin. Reproductive and respiratory diseases have been reported since 2001 in cattle, and more recently, diseases accompanied by a clinical presentation of mucosal disease-like (MD-like lesions have been reported as well. In the present study, the authors reported the oldest case of MD--like in cattle, associated with a HoBi-like pestivirus infection...
June 11, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29913323/association-between-injection-in-public-places-and-hiv-hcv-risk-behavior-among-people-who-use-drugs-in-ukraine
#9
Alyona Mazhnaya, Karin E Tobin, Jill Owczarzak
BACKGROUND: In Eastern Europe and Central Asia new HIV infections occur at a high rate among people who inject drugs (PWID). Injection risk behavior may be associated with injecting in public places. However, there is a lack of studies exploring this association in Ukraine, which has an HIV prevalence 21-42% among PWID. METHODS: Data came from a baseline survey of PWID recruited to participate in a behavioral HIV prevention intervention. The association between HIV/HCV injection risk behavior and place of injection (private vs...
June 8, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29913299/pharmacological-and-toxicological-study-of-a-chemical-standardized-ethanol-extract-of-the-branches-and-leaves-from-eysenhardtia-polystachya-ortega-sarg-fabaceae
#10
Angel Josabad Alonso-Castro, Juan Ramón Zapata-Morales, Victor Arana-Argáez, Julio Cesar Torres-Romero, Eyra Ramírez-Villanueva, Sabino Eduardo Pérez-Medina, Marco Antonio Ramírez-Morales, Mario Alberto Juárez-Méndez, Yessica Paola Infante-Barrios, Fidel Martínez-Gutiérrez, Candy Carranza-Álvarez, Mario Alberto Isiordia-Espinoza, Andrés Flores-Santos
Eysenhardtia polystachya is used for the empirical treatment of cancer, infections, diarrhea, inflammation, and pain. This study identified, using GC-MS, the main chemical components in an ethanol extract of E. polystachya branches and leaves (EPE) and tested its cytotoxic, antimicrobial, anti-diarrheal, anti-inflammatory, and antinociceptive effects. The in vitro and in vivo toxicity of EPE was evaluated using the comet assay in human peripheral blood mononuclear cells (PBMC) and the acute toxicity test in mice, respectively...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913285/epidemiology-and-clinical-outcomes-of-viral-central-nervous-system-infections
#11
Fatma Ben Abid, Mohammed Abukhattab, Hafedh Ghazouani, Obada Khalil, Ahmed Gohar, Hussam Al Soub, Muna Al Maslamani, Abdullatif Al Khal, Eman Al Masalamani, Said Al Dhahry, Samar Hashim, Faraj Howadi, Adeel A Butt
BACKGROUND: Central nervous system (CNS) viral infections are an important cause of morbidity and mortality. No data are available regarding their epidemiology in Qatar. DESIGN: We retrospectively evaluated all cerebrospinal fluid findings from January 2011-March 2015 at Hamad Medical Corporation. Those with abnormal CSF finding were included in our study. We excluded those with missing medical records, no clinical evidence of viral CNS infection or proven bacterial, fungal or tuberculosis CNS infection...
June 15, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29913266/the-mechanism-of-iron-compensation-for-manganese-deficiency-of-streptococcus-pneumoniae
#12
Kun Cao, Fubin Lai, Xin-Lu Zhao, Qiu-Xia Wei, Xin-Yu Miao, Ruiguang Ge, Qing-Yu He, Xuesong Sun
Given their involvement in catalysis, infection, and biofilm formation, Fe and Mn are essential for bacterial survival and virulence. In this study, we found that Streptococcus pneumoniae (S. pneumoniae) could grow in the Mn-deficient medium (MDCM). Furthermore, findings showed that the Fe concentration in the bacterium increased when the Mn concentration decreased. In addition, it was noted that supplementing MDCM with Fe resulted in the recovery of bacterial growth. Quantitative proteomics using stable-isotope dimethyl labeling was performed to investigate the adaptive growth mechanism of S...
June 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29913265/dipeptidylpeptidase-iv-of-streptococcus-suis-degrades-the-porcine-antimicrobial-peptide-pr-39-and-neutralizes-its-biological-properties
#13
Geneviève LeBel, Katy Vaillancourt, Li Yi, Marcelo Gottschalk, Daniel Grenier
Streptococcus suis is a major swine pathogen causing pathologies such as meningitis, sepsis, endocarditis, and arthritis. Several surface-bound and secreted proteases produced by S. suis have been identified and proposed as virulence factors. PR-39 is a proline/arginine-rich antimicrobial peptide produced by porcine leucocytes. In addition to play a role in innate immunity, this peptide possesses immunomodulatory properties. In this study, we hypothesized that proteases produced by S. suis inactivate PR-39...
June 15, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29913251/highly-efficient-inhibition-of-spring-viraemia-of-carp-virus-replication-in-vitro-mediated-by-bavachin-a-major-constituent-of-psoralea-corlifonia-lynn
#14
Chen Cheng, Shen Yu-Feng, Hu Yang, Liu Lei, Chen Wei-Chao, Wang Gao-Xue, Zhu Bin
As one of nine piscine viruses recognized by the International Office of Epizootics, spring viraemia of carp virus (SVCV) is an important pathogen bringing high mortality to cyprinids. Up to now, there is no approved therapy on SVCV, making them strong public health threat in aquaculture. In this study, the anti-SVCV activities of 12 plant crude extracts were investigated by using epithelioma papulosum cyprini (EPC) cells. Among these plants, Psoralea corylifolia Linn. showed the highest inhibition on SVCV replication, with an inhibitory percentage of 67...
June 15, 2018: Virus Research
https://www.readbyqxmd.com/read/29913249/variations-in-the-viral-genome-and-biological-properties-of-bovine-leukemia-virus-wild-type-strains
#15
Hironobu Murakami, Jumpei Uchiyama, Chihiro Suzuki, Sae Nikaido, Kaho Shibuya, Reiichiro Sato, Yosuke Maeda, Michiko Tomioka, Shin-Nosuke Takeshima, Hajime Kato, Masahiro Sakaguchi, Hiroshi Sentsui, Yoko Aida, Kenji Tsukamoto
Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis (EBL), which causes enormous economic losses in the livestock industry worldwide. To reduce the economic loss caused by BLV infection, it is important to clarify the characters associated with BLV transmissibility and pathogenesis in cattle. In this study, we focused on viral characters and examined spontaneous mutations in the virus and viral properties by analyses of whole genome sequences and BLV molecular clones derived from cows with and without EBL...
June 15, 2018: Virus Research
https://www.readbyqxmd.com/read/29913223/tacrolimus-has-immunosuppressive-effects-on-heavy-light-chain-pairs-and-free-light-chains-in-patients-after-heart-transplantation-a-relationship-with-infection
#16
Petra Lavríková, Peter Sečník, Zdenek Kubíček, Antonín Jabor, Lenka Hošková, Janka Franeková
The aim of the study was to investigate the relationship between tacrolimus (TAC) immunosuppressive treatment and serum concentrations of immunoglobulin heavy/light chain pairs (sHLC) and free light chains (sFLC) in patients after heart transplantation (HTX) and to use these biomarkers to predict the risk of infection in these patients. A total of 88 patients with an immunosuppressive regimen involving tacrolimus who underwent HTX were analyzed over 24 months of follow-up. sFLC and sHLC levels were determined before and at three time points after HTX...
June 15, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29913200/increased-t-cell-immunosenescence-and-accelerated-maturation-phenotypes-in-older-kidney-transplant-recipients
#17
J M Schaenman, M Rossetti, T Sidwell, V Groysberg, G Sunga, Y Korin, E Liang, X Zhou, B Abdallah, E Lum, S Bunnapradist, T Pham, G Danovitch, E F Reed
Older kidney transplant recipients experience increased rates of infection and death, and less rejection, compared with younger patients. However, little is known about immune dysfunction in older compared with younger kidney transplant recipients and whether it is associated with infection. We evaluated T cell phenotypes including maturation, immune senescence, and exhaustion in a novel investigation into differences in older compared with younger patients receiving identical immune suppression regimens. We evaluated PBMC from 60 kidney transplant recipients (23 older and 37 matched younger patients) by multiparameter immune phenotyping...
June 15, 2018: Human Immunology
https://www.readbyqxmd.com/read/29913173/diagnostic-accuracy-of-4-th-generation-architect-hiv-ag-ab-combo-assay-and-utility-of-signal-to-cutoff-ratio-to-predict-false-positive-hiv-tests-in-pregnancy
#18
Emily H Adhikari, Devin Macias, Donna Gaffney, Sarah White, Vanessa L Rogers, Donald D McIntire, Scott W Roberts
BACKGROUND: False positive HIV screening tests in pregnancy may lead to unnecessary interventions in labor. In 2014, the Centers for Disease Control and Prevention released a new algorithm for HIV diagnosis using a 4th generation screening test, which detects antibodies to HIV as well as p24 antigen and has a shorter window period compared with prior generations. A reactive screen requires a differentiation assay, and supplemental qualitative RNA testing is necessary for nonreactive differentiation assay...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29913091/-i-will-survive-a-tale-of-bacteriophage-bacteria-coevolution-in-the-gut
#19
Luisa De Sordi, Marta Lourenço, Laurent Debarbieux
Viruses that infect bacteria, or bacteriophages, are among the most abundant entities in the gut microbiome. However, their role and the mechanisms by which they infect bacteria in the intestinal tract remain poorly understood. We recently reported that intestinal bacteria are an evolutionary force, driving the expansion of the bacteriophage host range by boosting the genetic variability of these viruses. Here, we expand these observations by studying antagonistic bacteriophage-bacteria coevolution dynamics and revealing that bacterial genetic variability is also increased under the pressure of bacteriophage predation...
June 18, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29913082/darunavir-for-the-treatment-of-hiv-infection
#20
Vincenzo Spagnuolo, Antonella Castagna, Adriano Lazzarin
Darunavir (DRV) was the last approved protease inhibitor (PI) and has been extensively used for the treatment of HIV in both naïve and experienced subjects due to its high genetic barrier and efficacy. The introduction in clinical practice of integrase strand transfer inhibitors limited its role in the management of naïve subjects and in antiretroviral treatment simplification strategies. However, recent data from trials that have investigated the new DRV/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) combination showed an excellent efficacy and tolerability of this coformulation both in naïve patients and in those with viral suppression, making D/C/F/TAF a new option for the treatment of HIV infection...
June 18, 2018: Expert Opinion on Pharmacotherapy
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