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Gynecological oncology

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https://www.readbyqxmd.com/read/28938748/random-start-ovarian-stimulation-for-fertility-preservation-appears-unlikely-to-delay-initiation-of-neoadjuvant-chemotherapy-for-breast-cancer
#1
Joseph M Letourneau, Nikita Sinha, Kaitlyn Wald, Eve Harris, Molly Quinn, Tal Imbar, Evelyn Mok-Lin, A Jo Chien, Mitchell Rosen
STUDY QUESTION: Is random start ovarian stimulation associated with delays in initiation of neoadjuvant chemotherapy for breast cancer? SUMMARY ANSWER: Among women who complete fertility preservation (FP) consultation, random start ovarian stimulation is unlikely to delay time to initiation of neoadjuvant chemotherapy start. WHAT IS KNOWN ALREADY: Neoadjuvant chemotherapy is now a widely accepted treatment modality for operable breast cancer and random start ovarian stimulation is an increasingly-utilized modality for FP...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28937561/venous-thromboembolism-an-unrecognized-crisis-in-gynecologic-oncology
#2
Edward M Lichten
No abstract text is available yet for this article.
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28935272/genome-wide-association-study-evaluating-single-nucleotide-polymorphisms-and-outcomes-in-patients-with-advanced-stage-serous-ovarian-or-primary-peritoneal-cancer-an-nrg-oncology-gynecologic-oncology-group-study
#3
Kathleen N Moore, David Tritchler, Kenneth M Kaufman, Heather Lankes, Michael C J Quinn, Linda Van Le, Andrew Berchuck, Floor J Backes, Krishnansu S Tewari, Roger B Lee, Joshua P Kesterson, Robert M Wenham, Deborah K Armstrong, Thomas C Krivak, Michael A Bookman, Michael J Birrer
OBJECTIVE: This study evaluated single nucleotide polymorphisms (SNPs) associated with progression free (PFS) and overall survival (OS) in patients with advanced stage serous EOC. METHODS: Patients enrolled in GOG-172 and 182 who provided specimens for translational research and consent were included. Germline DNA was evaluated with the Illumina's HumanOMNI1-Quad beadchips and scanned using Illumina's iScan optical imaging system. SNPs with allele frequency>0...
September 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28930810/oncological-outcomes-of-stage-ii-endometrial-cancer-a-retrospective-analysis-of-250-cases
#4
Nejat Ozgul, Gokhan Boyraz, Mehmet Coskun Salman, Murat Gultekin, Kunter Yuce, Akbar Ibrahimov, Anil Erturk, Kemal Gungorduk, Varol Gulseren, Muzaffer Sanci, Osman Turkmen, Alper Karalok, Gunsu Kimyon, Taner Turan, Nazli Topfedaisi Ozkan, Mehmet Mutlu Meydanli, Tayfun Gungor, Hulya Ayik, Tayup Simsek
OBJECTIVE: The aim of this study was to investigate the effect of different surgical approaches, adjuvant therapy, and pathological characteristics on oncological outcomes in patients with 2009 International Federation of Gynecology and Obstetrics (FIGO) stage II endometrial cancer (EC). METHODS: A multicenter, retrospective department database review was performed to identify patients with FIGO 2009 stage II EC who underwent surgical staging between 2002 and 2015 at 5 gynecologic oncology centers in Turkey...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28930806/management-of-leimyosarcoma-a-survey-among-members-of-the-korean-gynecologic-oncology-group
#5
Mi Kyoung Kim, Taek Sang Lee, Jae-Weon Kim, Jong-Min Lee, Beob Jong Kim, Seok Ju Seong
OBJECTIVE: This study aimed to investigate current clinical management of leiomyosarcoma (LMS) in Korea. MATERIALS AND METHODS: We conducted a Web-based survey among members of the Korean Gynecologic Oncology Group regarding their treatment of LMS. RESULTS: In total, 77 (27.8%) of 277 members responded to the survey. For surgical treatment of stage I LMS, 26.8% indicated total hysterectomy only and 16.9% indicated total hysterectomy with bilateral salpingo-oophorectomy...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28925272/-fertility-preserving-methods-in-women-with-breast-cancer-before-gonadotoxic-therapy
#6
N Halászová, I Crha, M Huser, V Weinberger, J Žáková, M Ješeta, E Lousová, E Filipinská, P Ventruba
OBJECTIVE: To present current options and own experiences with ovarian stimulation in young women with breast cancer before gonadotoxic therapy. DESIGN: Review article with own experiencies. METHODS: Literary search, analysis of own experiences with complex therapy in women with breast cancer planning pregnancy, definitions of stimulating protocols, using methods of assisted reproduction. SETTING: Department of Obstetrics and Gynecology, Faculty of Medicine, Masaryk University and University Hospital Brno...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28911880/pelvic-exenteration-for-gynecologic-malignancies-postoperative-complications-and-oncologic-outcomes
#7
A Romeo, M I Gonzalez, J Jaunarena, M E Zubieta, G Favre, J C Tejerizo
INTRODUCTION AND OBJECTIVE: To evaluate complications, morbidity and oncologic outcomes of pelvic exenteration as treatment for gynecologic malignancies. MATERIALS AND METHODS: Between 2008 and 2015, a total of 35 patients underwent pelvic exenteration, due to recurrence of gynecological cancer. Surgical outcomes, early and late postoperative complications, and recurrence/survival outcomes were assessed. RESULTS: Mean patient age was 53.8 years...
September 11, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28892220/annual-report-of-the-committee-on-gynecologic-oncology-japan-society-of-obstetrics-and-gynecology-patient-annual-report-for-2014-and-treatment-annual-report-for-2009
#8
Toshiaki Saito, Fumiaki Takahashi, Hidetaka Katabuchi
The Japan Society of Obstetrics and Gynecology collects and analyzes annual data on gynecologic cancers from member institutions. We present the Patient Annual Report for 2014 and the Treatment Annual Report for 2009. Data on 7436 patients with cervical cancer, 9673 with endometrial cancer, 5924 with ovarian cancer, and 1909 with ovarian borderline tumor for whom treatment was initiated in 2014 were summarized in the Patient Annual Report. Stage I accounted for 55.6%, stage II for 22.9%, stage III for 10.2%, and stage IV for 11...
September 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28890424/revaluating-the-survival-effects-of-international-federation-of-gynecology-and-obstetrics-1988-stage-iiia-criteria-for-endometrial-cancer
#9
Osman Türkmen, Alper Karalok, Derman Başaran, Günsu Kimyon, Gizem Kul, Gökhan Tulunay, Işın Üreyen, Taner Turan
OBJECTIVE: This study aimed to define factors that affected survival in the International Federation of Gynecology and Obstetrics (FIGO) 1988 stage IIIA endometrial cancer (EC). MATERIAL AND METHODS: The study included patients with EC who underwent surgery between 1992 and 2013. Patients with adnexal metastases, uterine serosal involvement or positive peritoneal cytology (stage IIIA disease according to the former 1988 FIGO staging system) were selected for further analysis...
September 1, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28885339/role-of-chemotherapy-and-thrombolysis-in-treatment-of-choriocarcinoma-accompanied-with-pulmonary-embolism-a-case-report-with-literature-review
#10
Mei Yang, Li Peng
RATIONALE: Choriocarcinoma accompanied with pulmonary embolism (PE) is rare and difficult to diagnose and treat. There are about 25 cases reported in literature, which presented variable clinical characteristics and prognosis. PATIENT CONCERNS: We reported a case of choriocarcinoma presenting PE as the first manifestation in a 26-year-old Chinese female. DIAGNOSES: Four months before her admission to our hospital, she presented to a local hospital with respiratory manifestations, and was first diagnosed as bronchitis and treated with antibiotics without improvement, and subsequently suspected of having pulmonary tuberculosis and receive anti-tuberculosis therapy, with no response...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28885273/a-comparative-study-of-video-endoscopic-inguinal-lymphadenectomy-and-conventional-open-inguinal-lymphadenectomy-for-treating-vulvar-cancer
#11
Menglei Zhang, Limei Chen, Xuyin Zhang, Jingxin Ding, Keqin Hua
OBJECTIVE: This study aims to compare the complications, oncological outcomes, cosmetic satisfaction, and quality of life experienced by women with vulvar cancer undergoing video endoscopic inguinal lymphadenectomy (VEIL) versus conventional open inguinal lymphadenectomy (COIL). PATIENTS AND METHODS: Forty-eight consecutive patients with vulvar cancer who underwent COIL (n = 27) or VEIL (n = 21) at the Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China between 2003 and 2016 were included in this retrospective cohort study...
September 6, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28875470/the-impact-of-the-survivorship-care-plan-on-health-care-use-2-year-follow-up-results-of-the-rogy-care-trial
#12
Mette Moustgaard Jeppesen, Nicole P M Ezendam, Johanna M A Pijnenborg, M Caroline Vos, Dorry Boll, Roy F P M Kruitwagen, Pernille Tine Jensen, Lonneke V van de Poll-Franse
PURPOSE: The purpose of this paper was to assess the impact of survivorship care plan (SCP) provision and moderating factors on health care use following endometrial cancer treatment. METHODS: Women newly diagnosed with endometrial cancer were included in a pragmatic cluster randomized trial at 12 hospitals in the Netherlands and were randomly assigned to SCP or usual care (n = 221; 75% response). The SCP was generated using the web-based Registrationsystem Oncological GYnecology (ROGY) and provided tailored information regarding disease, treatment, and possible late-effects...
September 5, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28874598/-standard-care-in-cancer-clinical-trials-an-analysis-of-care-provided-to-women-in-the-control-arms-of-breast-cancer-clinical-trials
#13
Rachel F Dear, Kevin McGeechan, Megan B Barnet, Alexandra L Barratt, Martin H N Tattersall
Background: For trials to validly evaluate new treatments, comparison against the best existing alternative treatment is essential. We reviewed the care provided to women in control arms of breast cancer clinical trials to estimate the proportion consistent with the standard of care as defined in clinical guidelines. Methods: We analyzed phase III randomized controlled breast cancer trials comparing drug treatments with "standard care," enrolling between 2004 and 2014, and registered on ClinicalTrials.gov Our primary outcome was the proportion of trials in which treatment in the control arm was consistent with concurrent NCCN Guidelines...
September 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28872976/serum-il-6-and-il-8-correlate-with-prognostic-factors-in-ovarian-cancer
#14
Marcela Moisés Maluf Sanguinete, Paula Honório De Oliveira, Agrimaldo Martins-Filho, Douglas Côbo Micheli, Beatriz Martins Tavares-Murta, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini
The aim of the study was to correlate serum levels of IL-2, IL-5, IL-6, IL-8, IL-10, and TNF-α with clinical, laboratory, and pathological prognostic factors in patients with primary ovarian malignancy. Patients treated at the Pelvic Mass Ambulatory of the Discipline of Gynecology and Obstetrics/Oncology Research Institute (IPON) of the UFTM with confirmed diagnosis of malignant ovarian neoplasia (n = 26) were evaluated. Serum collection was performed preoperatively for the determination of tumor markers...
October 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28871417/review-of-enhanced-recovery-programs-in-benign-gynecologic-surgery
#15
REVIEW
Elisa R Trowbridge, Caitlin N Dreisbach, Bethany M Sarosiek, Catherine Page Dunbar, Sarah Larkin Evans, Lee Anne Hahn, Kathie L Hullfish
INTRODUCTION AND HYPOTHESIS: Enhanced recovery programs (ERPs) are evidence-based protocols designed to improve functional rehabilitation after surgery. ERPs have gained widespread acceptance in many surgical disciplines, and their use leads to significant improvements in patient outcomes while reducing hospital length of stay (LOS). There remains a paucity of data on the use of ERPs in benign gynecologic surgery. The purpose of this review was to evaluate current literature on the use of ERP concepts in benign gynecologic surgery...
September 4, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28870960/risk-reducing-salpingo-oophorectomy-in-women-at-higher-risk-of-ovarian-and-breast-cancer-a-single-institution-prospective-series
#16
Enzo Ricciardi, Federica Tomao, Giovanni Aletti, Luca Bazzurini, Luca Bocciolone, Sara Boveri, Fabio Landoni, Maria Teresa Lapresa, Matteo Maruccio, Gabriella Parma, Fedro Peccatori, Maria Cristina Petrella, Vanna Zanagnolo, Nicoletta Colombo, Angelo Maggioni
BACKGROUND/AIM: Occult cancers' reported rates vary from 2-12% and serous tubal intraepithelial carcinomas (STICs) have been identified in 3-12% of the prophylactically removed tubes of women carrying a BRCA mutation. The aim of this study was to evaluate the incidence of tubal minor epithelial atypia (STIL), STIC, and occult invasive cancer and to evaluate the cancer-specific mortality in a prospective series of women at higher risk of ovarian and breast cancer undergoing risk-reducing salpingo-oophorectomy (RRSO) n a tertiary cancer center...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870525/rectal-balloon-use-limits-vaginal-displacement-rectal-dose-and-rectal-toxicity-in-patients-receiving-imrt-for-postoperative-gynecological-malignancies
#17
Cheng-Chia Wu, Yen-Ruh Wuu, Theodore Yanagihara, Ashish Jani, Eric P Xanthopoulos, Akhil Tiwari, Jason D Wright, William M Burke, June Y Hou, Ana I Tergas, Israel Deutsch
Pelvic radiotherapy for gynecologic malignancies traditionally used a 4-field box technique. Later trials have shown the feasibility of using intensity-modulated radiotherapy (IMRT) instead. But vaginal movement between fractions is concerning when using IMRT due to greater conformality of the isodose curves to the target and the resulting possibility of missing the target while the vagina is displaced. In this study, we showed that the use of a rectal balloon during treatment can decrease vaginal displacement, limit rectal dose, and limit acute and late toxicities...
September 1, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28866783/what-is-the-impact-of-stromal-microinvasion-on-oncologic-outcomes-in-borderline-ovarian-tumors-a-multicenter-case-control-study
#18
Gokhan Boyraz, Mehmet Coskun Salman, Murat Gultekin, Nazlı Topfedaisi Ozkan, Hasan H Uckan, Kemal Gungorduk, Varol Gulseren, Hulya Ayik, Tayfun Toptas, Oguzhan Kuru, Hamdullah Sozen, Anıl Erturk, Nejat Ozgul, Mehmet Mutlu Meydanlı, Muzaffer Sanci, Taner Turan, Tayfun Gungor, Tayup Simsek, Samet Topuz, Kunter Yuce
PURPOSE: To investigate clinicopathological characteristics and oncological outcome of women with microinvasive BOTs. METHODS: A retrospective multicenter case-control study was conducted on 902 patients with BOT, who underwent surgery from January 2002 to December 2015 at six participating gynecologic oncology centers from Turkey. Among 902 patients, 69 had microinvasive BOT. For every patient with microinvasive BOT, two controls were randomly selected from another database based on decade of age and stage of disease at diagnosis...
September 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28865449/association-between-self-perception-of-aging-view-of-cancer-and-health-of-older-patients-in-oncology-a-one-year-longitudinal-study
#19
Sarah Schroyen, Pierre Missotten, Guy Jerusalem, M Van den Akker, F Buntinx, Stéphane Adam
BACKGROUND: Identifying older people affected by cancer who are more at risk of negative health outcomes is a major issue in health initiatives focusing on medical effectiveness. In this regard, psychological risk factors such as patients' perception of their own aging and cancer could be used as indicators to improve customization of cancer care. We hypothesize that more negative self-perception of aging (SPA) and view of cancer could be linked to worse physical and mental health outcomes in cancer patients...
September 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28862207/effectiveness-of-intraperitoneal-or-intrapleural-administration-of-triamcinolone-acetonide-for-the-control-of-malignant-ascites-and-pleural-effusion-kansai-clinical-oncology-group-g1102-study
#20
Kimihiko Ito, Hiroshi Tsubamoto, Kayo Inoue, Yukari Miyoshi, Yoshihiro Ito, Kensuke Hori
OBJECTIVES: We conducted a retrospective multi-institutional study to evaluate the efficacy and toxicity of intraperitoneal or intrapleural triamcinolone acetonide (TA), a slowly metabolized corticosteroid administration for the management of malignant ascites or pleural effusion. MATERIALS AND METHODS: The medical records of patients with gynecologic cancer who were treated with paracentesis or thoracocentesis followed by administration of 400 mg of TA between 2005 and 2014 were reviewed...
July 2017: Journal of Cancer Research and Therapeutics
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