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Gynecological oncology

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https://www.readbyqxmd.com/read/29778506/quality-of-life-symptoms-and-care-needs-in-patients-with-persistent-or-recurrent-platinum-resistant-ovarian-cancer-an-nrg-oncology-gynecologic-oncology-group-study
#1
Vivian E von Gruenigen, Helen Q Huang, David Cella, MichaelA Zevon, Jason A LaChance, Joan L Walker, Ritu Salani, Susan C Modesitt, Robert T Morris, William H Bradley, Matthew P Boente, Lari Wenzel
OBJECTIVES: The goals of treating recurrent platinum-resistant ovarian cancer are palliative, aimed at reducing symptoms and improving progression free survival. A prospective trial was conducted to determine the prevalence and severity of symptoms, and associated care needs. METHODS: Eligible women included those with persistent or recurrent platinum-resistant ovarian cancer with an estimated life expectancy of at least 6 months. The Needs at the End-of-Life Screening Tool (NEST), FACIT-Fatigue (FACIT-F), NCCN-FACT Ovarian Symptom Index [NFOSI-18]; Disease Related Symptoms (DRS), Treatment Side Effects (TSE), and Function/Well Being (F/WB) were collected at study entry, 3 and 6 months...
May 17, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29778392/ultrasound-guided-follicle-aspiration-at-time-of-laparotomy-in-a-patient-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#2
Ashley M Eskew, Darcy E Broughton, Maureen B Schulte, Kenan R Omurtag, Randall R Odem
OBJECTIVE: To demonstrate a unique case of direct ultrasound-guided follicle aspiration at time of a laparotomy in a patient with Mayer-Rokitansky-Küster-Hauser Syndrome. DESIGN: Video presentation. SETTING: Academic fertility center PATIENT(S): A 32-year-old gravida 0 with Mayer-Rokitansky-Küster-Hauser Syndrome and bilateral ovarian masses presented as a fertility preservation consult from gynecologic oncology due to the possibility of bilateral oophorectomy...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29775688/gyneco-oncological-genomics-and-emerging-biomarkers-for-cancer-treatment-with-immune-checkpoint-inhibitors
#3
REVIEW
Giuseppe Curigliano
In gynecological cancers tumor infiltrating lymphocytes and upregulation of immune-related gene signatures have been associated with a better prognosis. Knowledge of tumor immunogenicity and associated gene signatures suggests that the tumor immune landscape is a key determinant to define patient prognosis and potentially to predict response to immune-checkpoint inhibitors. The aim of this review is to give an overview of immune gene signatures across gynecology histological cancer types, defining their prognostic and potential predictive role...
May 15, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29774521/patient-reported-outcomes-of-multiple-myeloma-patients-treated-with-panobinostat-after-%C3%A2-2-lines-of-therapy-based-on-the-international-phase-3-randomized-double-blind-placebo-controlled-panorama-1-trial
#4
Paul G Richardson, Robert L Schlossman, Anuja N Roy, Ashok Panneerselvam, Suddhasatta Acharyya, Monika Sopala, Sagar Lonial
The phase 3 PANORAMA-1 trial led to regulatory approvals of panobinostat (PAN) in combination with bortezomib (BTZ) and dexamethasone (DEX) for the treatment of multiple myeloma after ≥2 prior regimens, including BTZ and an immunomodulatory drug. Patient-reported outcomes (PROs) were assessed in PANORAMA-1, with data available for 73 patients in the PAN + BTZ + DEX arm and 74 patients in the placebo (PBO) + BTZ + DEX arm. Per the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30), global health status/quality of life (QoL) scores initially declined with PAN + BTZ + DEX during the first 24 weeks before approaching baseline scores and remaining steady during the next 24 weeks, with no difference between arms at Week 48...
May 17, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29770626/practice-guidelines-for-management-of-ovarian-cancer-in-korea-a-korean-society-of-gynecologic-oncology-consensus-statement
#5
REVIEW
Dong Hoon Suh, Suk Joon Chang, Taejong Song, Sanghoon Lee, Woo Dae Kang, Sun Joo Lee, Ju Won Roh, Won Duk Joo, Joo Hee Yoon, Dae Hoon Jeong, Hee Seung Kim, Sung Jong Lee, Yong Il Ji, Hyun Jung Kim, Jeong Won Lee, Jae Weon Kim, Duk Soo Bae
Since after 2006 when the first edition of practice guidelines for gynecologic oncologic cancer treatment was released, the Korean Society of Gynecologic Oncology (KSGO) has published the following editions on a regular basis to suggest the best possible standard care considering updated scientific evidence as well as medical environment including insurance coverage. The Guidelines Revision Committee was summoned to revise the second edition of KSGO practice guidelines, which was published in July 2010, and develop the third edition...
March 10, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29770619/impact-of-lymph-node-ratio-on-survival-in-stage-iiic-endometrioid-endometrial-cancer-a-turkish-gynecologic-oncology-group-study
#6
Ali Ayhan, Nazlı Topfedaisi Ozkan, Murat Öz, Günsu Kimyon Comert, Zeliha Firat Cuylan, Gonca Çoban, Osman Turkmen, Baki Erdem, Hanifi Şahin, Özgür Akbayır, Murat Dede, Ahmet Taner Turan, Husnu Celik, Tayfun Güngör, Ali Haberal, Macit Arvas, Mehmet Mutlu Meydanli
OBJECTIVE: The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in women with stage IIIC endometrioid endometrial cancer (EC). METHODS: A multicenter, retrospective department database review was performed to identify patients with stage IIIC pure endometrioid EC at 6 gynecologic oncology centers in Turkey. A total of 207 women were included. LNR, defined as the percentage of positive lymph nodes (LNs) to total nodes recovered, was stratified into 2 groups: LNR1 (≤0...
March 13, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29767847/access-to-quality-gynecologic-oncology-care-a-work-in-progress
#7
EDITORIAL
Linda R Duska
No abstract text is available yet for this article.
May 16, 2018: Cancer
https://www.readbyqxmd.com/read/29767846/access-to-gynecologic-oncology-care-and-the-network-adequacy-standard
#8
David I Shalowitz, Warner K Huh
No abstract text is available yet for this article.
May 16, 2018: Cancer
https://www.readbyqxmd.com/read/29766779/technetium-99m-based-radiopharmaceuticals-in-sentinel-lymph-node-biopsy-gynecologic-oncology-perspective
#9
Kamil Zalewski, Malgorzata Benke, Bartlomiej Mirocha, Jakub Radziszewski, Magdalena Chechlinska, Magdalena Kowalewska
Technetium (99mTc)-radiolabeled colloids are popular tracers used to map lymphatic vessels and regional lymph nodes (LNs). The regional LN status is a significant determinant of cancer stage and patient prognosis, and strongly influences treatment. Regional LN dissection has become part of surgical treatment. However, not all patients with LN involvement benefit from extensive lymphadenectomy in terms of prolonged survival. Moreover, overtreatment of patients with localized disease carries unnecessary risk of complications...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29762198/endometrial-cancer-in-the-elderly-does-age-influence-surgical-treatments-outcomes-and-prognosis
#10
Meriem Koual, Charlotte Ngo, Aude Girault, Fabrice Lécuru, Anne-Sophie Bats
OBJECTIVE: To compare clinicopathological characteristics, surgical outcomes, and survival rates for nonelderly (<75 years old) and elderly (≥75 years old) women with endometrial cancer (EC). METHODS: This retrospective study included consecutive patients who underwent surgery for EC at the gynecologic-oncologic surgery department of Hôpital Européen Georges-Pompidou (Paris, France) from January, 2002 to December, 2015. Independent-group t tests and chi-square tests were used to compare elderly and nonelderly women...
May 14, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29757877/report-from-the-20th-meeting-of-the-european-society-of-gynaecological-oncology-esgo-2017
#11
Kamil Zalewski, Elisa Piovano, Zoia Razumova, Ilker Selcuk, Tanja Nikolova
This is a report from the 20th Meeting of the European Society of Gynaecological Oncology (ESGO) held in Vienna, Austria on November 4 to 7, 2017. The conference offered state-of-the-art educational sessions and oral and poster abstract presentations. The general sessions throughout the meeting focused not only on prevention, screening, diagnosis, treatment, and translational research but also emerging trends, and current innovations in gynecological cancers were discussed. The ESGO-European Society for Radiotherapy and Oncology-European Society of Pathology guidelines on management of cervical cancers were reported for the first time in public...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29757874/the-clearance-of-serum-human-epididymis-protein-4-following-primary-cytoreductive-surgery-for-ovarian-carcinoma
#12
Claire Thompson, Waseem Kamran, Lucy Dockrell, Srwa Khalid, Meena Kumari, Nadia Ibrahim, John OʼLeary, Lucy Norris, Max Petzold, Sharon OʼToole, Noreen Gleeson
OBJECTIVE: The aim of this study was to examine the clearance of serum human epididymis protein 4 (HE4) in the immediate postoperative period in patients undergoing maximal effort cytoreductive surgery for ovarian carcinoma. METHODS: The study was performed at a tertiary gynecologic oncology center. The surgery was performed by accredited gynecological oncologists. RESULTS: Preoperative and serial postoperative venous blood samples at 4, 8, 24, 48, 72, 96, and 120 hours were taken from 10 sequential patients...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29757719/providing-mr-imaging-for-cervical-cancer-brachytherapy-lessons-for-radiologists
#13
Thomas Sullivan, Joseph H Yacoub, Matthew M Harkenrider, William Small, Murat Surucu, Steven M Shea
Brachytherapy (BT), the use of a locally placed or implanted radioactive source for treatment of an adjacent tumor, is an important component in the treatment of patients with both early- and advanced-stage cervical cancer and is increasingly part of the standard treatment protocol. When it is feasible, many radiation oncologists choose to include a magnetic resonance (MR) imaging examination for planning BT treatment (ie, an MR imaging examination after placement of the applicator but before radiation dosing)...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29755762/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-ovarian-and-gastrointestinal-peritoneal-carcinomatosis-results-from-a-7-year-experience
#14
Giulia Montori, Federico Coccolini, Paola Fugazzola, Marco Ceresoli, Matteo Tomasoni, Carolina Rubicondo, Stefano Raimondo, Domenico Pinelli, Michele Colledan, Luigi Frigerio, Luca Ansaloni
Background: An increasing promising evidence and increasing long-term oncologic outcomes support the use of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as locoregional treatment for peritoneal carcinosis (PC) especially from ovarian and gastrointestinal tumors, but also for others cancers. Methods: A prospective monocentric study was performed in Papa Giovanni XXIII Hospital, Bergamo (Italy). Patients and tumor characteristics were analyzed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29735328/gynaecologic-cancer-surgery-and-preservation-of-fertility
#15
E Bentivegna, A Maulard, G Miailhe, S Gouy, P Morice
For gynecological cancers, even at an early stage, the standard treatment is "radical excision" involving hysterectomy (radical or not) with bilateral salpingo-oophorectomy. But for young patients with early stage disease, many recent studies have focused on preservation of subsequent fertility by keeping at least one ovary and the uterus. The main objective of this fertility-sparing surgery is to preserve fertility, if this can be accomplished without increasing the oncological risks. Whether the initial site of the cancer is the cervix, uterine fundus or ovary, the oncologic validation of fertility-sparing treatment requires several evaluation criteria: a rigorous clinical, radiological and surgical staging to verify that the pathology is truly at an early initial stage; expert pathologic interpretation of biopsy specimens to validate the histological criteria of "good prognosis"; provision of complete and understandable patient education verifying the true objectives for this fertility-sparing treatment (whose intent is to retain a potential for subsequent fertility without guaranteeing it) and provision of an explanation of the oncological constraints and implications of fertility-sparing surgery in the event of a possible pregnancy...
May 4, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29729931/expanding-the-pipeline-the-2018-society-of-gynecologic-oncology-presidential-address-sunday-march-25-2018-by-laurel-w-rice-md-2017-2018-sgo-president
#16
https://www.readbyqxmd.com/read/29728846/increasing-provider-awareness-of-and-recommendations-for-yoga-and-meditation-classes-for-cancer-patients
#17
Mallory J Koula, Jennifer M Knight
OBJECTIVE: The purpose of the current study was to (1) assess healthcare providers' beliefs about and referral patterns to yoga and meditation services, and (2) evaluate the effectiveness of a brief yoga/meditation educational presentation to increase providers' intent to recommend these programs. METHOD: A brief 5-min presentation regarding the benefits of yoga and meditation for cancer patients and instruction about referring and enrolling patients was delivered in four different oncology settings: breast, gynecologic, radiation, and surgical...
May 4, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29727351/comparison-of-different-surgical-approaches-for-stage-ib1-cervical-cancer-patients-a-multi-institution-study-and-a-review-of-the-literature
#18
Giacomo Corrado, Enrico Vizza, Francesco Legge, Luigi Pedone Anchora, Isabella Sperduti, Anna Fagotti, Emanuela Mancini, Valerio Gallotta, Ashanti Zampa, Benito Chiofalo, Giovanni Scambia
OBJECTIVE: The aim of this retrospective study was to assess the surgical and oncological outcome of 3 different surgical approaches (laparotomy, laparoscopy, and robotic surgery) in the treatment of early-stage cervical cancer International Federation of Gynecology and Obstetrics (FIGO) stage IB1. METHODS: All patients with a histologically confirmed diagnosis of early-stage cervical cancer, FIGO stage IB1, who underwent abdominal radical hysterectomy (ARH), laparoscopic radical hysterectomy, or robotic radical hysterectomy with or without pelvic and aortic lymphadenectomy were included in the study...
April 30, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29727349/the-feasibility-of-laparoscopic-surgery-in-gynecologic-oncology-for-obese-and-morbidly-obese-patients
#19
Jessie Peng, Sarah Sinasac, Katherine J Pulman, Liying Zhang, Joan Murphy, Tomer Feigenberg
BACKGROUND: Surgical interventions are the mainstay of treatment for many gynecological cancers. Although minimally invasive surgery offers many potential advantages, performing laparoscopic pelvic surgery in obese patients remains challenging. To overcome this, many centers have shifted their practice to robotic surgery; however, the high costs associated with robotic surgery are concerning and limit its use. OBJECTIVE: This study aimed to examine the feasibility of performing laparoscopic gynecologic oncology procedures in obese and morbidly obese patients...
June 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29727055/prognostic-factors-for-maximally-or-optimally-cytoreduced-stage-iii-nonserous-epithelial-ovarian-carcinoma-treated-with-carboplatin-paclitaxel-chemotherapy
#20
Zeliha F Cuylan, Mehmet M Meydanli, Mustafa E Sari, Ozgur Akbayir, Husnu Celik, Murat Dede, Hanifi Sahin, Kemal Gungorduk, Esra Kuscu, Nejat Ozgul, Tayfun Gungor, Ali Ayhan
OBJECTIVE: To identify factors predictive of poor prognosis in women with stage III nonserous epithelial ovarian cancer (EOC) who had undergone maximal or optimal primary cytoreductive surgery (CRS) followed by six cycles of intravenous carboplatin/paclitaxel chemotherapy. METHODS: A multicenter, retrospective department database review was performed to identify patients with stage III nonserous EOC who had undergone maximal or optimal primary CRS followed by six cycles of carboplatin/paclitaxel chemotherapy at seven gynecological oncology centers in Turkey...
May 4, 2018: Journal of Obstetrics and Gynaecology Research
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