Issam Raad, Anne-Marie Chaftari, Ramia Zakhour, Mary Jordan, Zanaib Al Hamal, Ying Jiang, Ammar Yousif, Kumait Garoge, Victor Mulanovich, George M Viola, Soha Kanj, Egbert Pravinkumar, Joel Rosenblatt, Ray Hachem
In cancer patients with long-term central venous catheters (CVC), removal and reinsertion of a new CVC at a different site might be difficult because of the unavailability of accessible vascular sites. In vitro and animal studies showed that a minocycline-EDTA-ethanol (M-EDTA-EtOH) lock solution may eradicate microbial organisms in biofilms, hence enabling the treatment of central line-associated bloodstream infections (CLABSI) while retaining the catheter in situ Between April 2013 and July 2014, we enrolled 30 patients with CLABSI in a prospective study and compared them to a historical group of 60 patients with CLABSI who had their CVC removed and a new CVC inserted...
June 2016: Antimicrobial Agents and Chemotherapy