keyword
https://read.qxmd.com/read/38534880/successful-bone-marrow-transplantation-in-a-patient-with-acute-myeloid-leukemia-developed-from-severe-congenital-neutropenia-using-modified-chemotherapy-and-conditioning-regimen-for-leukemia
#1
Risa Matsumura, Shinji Mochizuki, Yusuke Morishita, Hiroko Hayakawa, Shuhei Karakawa, Hiroshi Kawaguchi, Satoshi Okada, Nobuyuki Hyakuna, Masao Kobayashi
Severe congenital neutropenia (SCN) is characterized by chronic neutropenia with recurrent infections from early infancy and a predisposition to myelodysplastic syndrome/acute myeloid leukemia (AML). Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with SCN who develop myelodysplastic syndrome/AML. We report an 8-year-old girl with SCN carrying an ELANE mutation that had been refractory to granulocyte colony-stimulating factor. The patient experienced recurrent infections and then developed AML...
February 26, 2024: Hematology Reports
https://read.qxmd.com/read/38533771/head-and-neck-reconstruction-with-the-superficial-circumflex-iliac-artery-perforator-scip-free-flap-lessons-learned-after-73-cases
#2
JOURNAL ARTICLE
Mario F Scaglioni, Matteo Meroni, Patrick E Tomasetti, Gunesh P Rajan
BACKGROUND: Head and neck tissue defects after ablative surgery often require complex and composite reconstructions. The superficial circumflex iliac artery perforator (SCIP) flap is an extremely versatile perforator-based flap with minimal donor site morbidity, which may represent the optimal procedure in this setting. Over the last 5 years, we collected a large base of experience, including both simple and chimeric SCIP-based reconstruction, making this flap our first choice for head and neck reconstructions...
March 27, 2024: Head & Neck
https://read.qxmd.com/read/38532680/-experience-of-providing-intensive-rehabilitation-care-to-a-school-aged-child-with-living-donor-lobar-lung-transplantation
#3
JOURNAL ARTICLE
Chiao-Ting Tsai, Fang-Yi Lin
The post-operative intensive care experience of a school-aged child who received living-donor bilateral lobar lung transplantation due to acute respiratory distress syndrome and interstitial pulmonary fibrosis is discussed in this paper. The patient received lungs donated by her parents in a "living-donor bilateral lobar lung transplantation" due to severe lung function impairment. The patient felt anxious due to her long-term hospitalization for preoperative evaluation, various invasive treatments, and postoperative rehabilitation...
April 2024: Hu Li za Zhi the Journal of Nursing
https://read.qxmd.com/read/38531129/effects-of-yeast-inoculation-methods-on-caproic-acid-production-and-microbial-community-during-anaerobic-fermentation-of-chinese-cabbage-waste
#4
JOURNAL ARTICLE
Ranran Chen, Xiaonan Zhou, Liu Huang, Xiaofeng Ji, Zhengang Chen, Jiying Zhu
To provide a sufficient supply of electron donors for the synthesis of caproic acid, yeast fermentation was employed to increase ethanol production in the anaerobic fermentation of Chinese cabbage waste (CCW). The results showed that the caproic acid yield of CCW with ethanol pre-fermentation was 7750.3 mg COD/L, accounting for 50.2% of the total volatile fatty acids (TVFAs), which was 32.5% higher than that of the CCW without yeast inoculation. The synchronous fermentation of yeast and seed sludge significantly promoted the growth of butyric acid consuming bacterium Bacteroides, resulting in low yields of butyric acid and caproic acid...
March 25, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38527905/multidisciplinary-approach-for-hepatocellular-carcinoma-patients-current-evidence-and-future-perspectives
#5
JOURNAL ARTICLE
Joo Hyun Oh, Dong Hyun Sinn
Management of hepatocellular carcinoma (HCC) is challenging due to the complex relationship between underlying liver disease, tumor burden, and liver function. HCC is also notorious for its high recurrence rate even after curative treatment for early-stage tumor. Liver transplantation can substantially alter patient prognosis, but donor availability varies by each patient which further complicates treatment decision. Recent advancements in HCC treatments have introduced numerous potentially efficacious treatment modalities...
March 25, 2024: Journal of liver cancer
https://read.qxmd.com/read/38524260/percutaneous-transhepatic-sphincterotome-guided-management-of-post-living-donor-liver-transplant-biliary-anastomotic-stricture-an-innovative-approach
#6
Usman Iqbal Aujla, Imran Ali Syed, Ahmad Karim Malik, Muhammad Ramzan, Abdullah Saeed
Post-liver transplantation biliary complications remain a serious concern and are associated with reduced patient and graft survival. Among various biliary complications, anastomotic stricture (AS) is the most frequent and challenging one. The frequency of AS after living donor liver transplantation (LDLT) is higher as compared to deceased donor liver transplantation. The management involves endoscopic retrograde cholangiopancreatography and/or percutaneous transhepatic biliary drainage, but refractory cases necessitate surgical revision...
March 2024: ACG Case Reports Journal
https://read.qxmd.com/read/38523030/advancing-immunosuppression-in-liver-transplantation-a-narrative-review
#7
REVIEW
Samuele Iesari, Francesca Laura Nava, Ilaria Elena Zais, Laurent Coubeau, Mariano Ferraresso, Evaldo Favi, Jan Lerut
Immunosuppression is essential to ensure recipient and graft survivals after liver transplantation (LT). However, our understanding and management of the immune system remain suboptimal. Current immunosuppressive therapy cannot selectively inhibit the graft-specific immune response and entails a significant risk of serious side effects, i.e., among others, de novo cancers, infections, cardiovascular events, renal failure, metabolic syndrome, and late graft fibrosis, with progressive loss of graft function. Pharmacological research, aimed to develop alternative immunosuppressive agents in LT, is behind other solid-organ transplantation subspecialties, and, therefore, the development of new compounds and strategies should get priority in LT...
March 16, 2024: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/38522764/differences-in-excess-mortality-by-recipient-sex-after-heart-transplant-an-individual-patient-data-meta-analysis
#8
JOURNAL ARTICLE
Amanda J Vinson, Xun Zhang, Mourad Dahhou, Caner Süsal, Bernd Döhler, Anette Melk, Ruth Sapir-Pichhadze, Heloise Cardinal, Germaine Wong, Anna Francis, Helen Pilmore, Lauren T Grinspan, Bethany J Foster
BACKGROUND: Identification of differences in mortality risk between female and male heart transplant recipients may prompt sex-specific management strategies. Because worldwide, males of all ages have higher absolute mortality rates than females, we aimed to compare the excess risk of mortality (risk above the general population) in female versus male heart transplant recipients. METHODS: We used relative survival models conducted separately in SRTR and CTS cohorts from 1988-2019, and subsequently combined using two-stage individual patient data meta-analysis, to compare the excess risk of mortality in female versus male first heart transplant recipients, accounting for the modifying effects of donor sex and recipient current age...
March 22, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38521704/follicular-unit-grafting-in-chronic-ulcers-a-valuable-technique-for-integrated-management
#9
JOURNAL ARTICLE
Anahi Belatti, Florencia Bertarini, Virginia Pombo, Luis Mazzuoccolo, Damian Ferrario
Chronic ulcers significantly affect the quality of life of patients and impose a high cost on the healthcare system. The therapeutic management should be comprehensive, taking into consideration the etiological diagnosis of the wound and the characteristics of the wound bed when deciding on a therapeutic proposal appropriate to the healing phase, correcting factors that delay healing. During the epithelialization phase, repair techniques with grafts are recommended to shorten re-epithelialization time, improve the quality of scar tissue, and achieve adequate pain management...
March 22, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38521527/realist-evaluation-of-maternity-waiting-home-intervention-models-in-inhambane-mozambique-protocol-for-a-comparative-embedded-case-study-the-mozambique-canada-maternal-health-project
#10
JOURNAL ARTICLE
Nadege Sandrine Uwamahoro, Jessie Forsyth, Fernanda Andre, Dórcia António Mandlate, Brynne Gilmore, Nazeem Muhajarine
INTRODUCTION: This is a study protocol that tests and refines realist theories regarding the uptake and scale-up of the linked maternity waiting home (hereafter MWH) and facility birth intervention in the Mozambican context. The theories were developed through a realist review of MWH-facility birth literature from low-income and middle-income countries. The aim of the proposed study is to contribute to a contextually refined understanding of the causal chains underlying MWH-facility birth adoption by pregnant women and their families, communities, the health system and donors...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38519381/pain-is-what-hurts-an-exploration-of-perception-and-management-of-pain-in-peripheral-blood-stem-cell-donors
#11
JOURNAL ARTICLE
Suzanna M van Walraven, Leon C Witte, Femmeke Prinsze, Johanna C Wiersum-Osselton, Ivan Bank
BACKGROUND: Pain is a side effect of Granulocyte-Colony Stimulating Factor (G-CSF) administration. This prospective study investigates various aspects including pain perception occurring in Peripheral Blood Stem Cell (PBSC) donors. MATERIALS AND METHODS: Related and unrelated PBSC donors were prospectively studied. Donors recorded pain symptoms during the four-day period of G-CSF administration using the McGill Pain Questionnaire, a Visual Analog Scale and a pain diary...
March 19, 2024: Transfusion and Apheresis Science
https://read.qxmd.com/read/38518128/a-case-of-female-x-linked-chronic-granulomatous-disease-caused-by-x-chromosome-inactivation-treated-with-hematopoietic-stem-cell-transplantation-and-literature-review
#12
JOURNAL ARTICLE
Wei Lu, Xiaoqin Xi, Yuanfang Jing, Yingjian Si, Zhenlan Du, Ya Wang, Wei Chen, Xiangfeng Tang
OBJECTIVE: X-linked chronic granulomatous disease (X-CGD) is a rare primary immunodeficiency disease characterized by phagocyte dysfunction. It is caused by genetic mutations in the CYBB gene, predominantly affecting males. However, a small number of female carriers can also present with the disease due to biased X chromosome inactivation.1 This study aims to enhance the understanding of X-CGD in a rare case of an infant and young woman and provide insights into its diagnosis and treatment...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38517315/research-advancements-on-nerve-guide-conduits-for-nerve-injury-repair
#13
REVIEW
Shoushuai Wang, Xinggui Wen, Zheyuan Fan, Xiangdong Ding, Qianqian Wang, Zhongling Liu, Wei Yu
Peripheral nerve injury (PNI) is one of the most serious causes of disability and loss of work capacity of younger individuals. Although PNS has a certain degree of regeneration, there are still challenges like disordered growth, neuroma formation, and incomplete regeneration. Regarding the management of PNI, conventional methods such as surgery, pharmacotherapy, and rehabilitative therapy. Treatment strategies vary depending on the severity of the injury. While for the long nerve defect, autologous nerve grafting is commonly recognized as the preferred surgical approach...
March 25, 2024: Reviews in the Neurosciences
https://read.qxmd.com/read/38515600/health-transformation-toward-universal-healthcare-coverage-amidst-conflict-examining-the-impact-of-international-cooperation-in-niger
#14
Mahamadou Doutchi, Abdoulaye Ghousmane, Fatimata Zampaligre, Bizo Moussa, El Khalef Ishagh, Ouédraogo Talatou Marc, Batouré Oumarou, Mutenda Sheria Kaya, Gbaguidi Aichatou Diawara, Abdoulaye Macire Camara, Seyni Moussa, Kuyangisa Bienvenu, Joseph Toko, Hamidou Harouna, Haladou Moussa, N'Zue Kofi, Jacques Lukenze Tamuzi, Patrick D M C Katoto, Charles S Wiysonge, Blanche-Philomene Melanga Anya
BACKGROUND: Approximately 70% of Sub-Saharan African countries have experienced armed conflicts with significant battle-related fatalities in the past two decades. Niger has witnessed a substantial rise in conflict-affected populations in recent years. In response, international cooperation has aimed to support health transformation in Niger's conflict zones and other conflict-affected areas in Sub-Saharan Africa. This study seeks to review the available evidence on health interventions facilitated by international cooperation in conflict zones, with a focus on Niger...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38515503/acute-viral-hepatitis-e-infection-complicating-postliving-liver-donor-hepatectomy-recovery
#15
JOURNAL ARTICLE
Kaleem Ullah, Sidhant Ochani, Hafiz B Ahmad
This study presents a case of a living liver donor who developed a hepatitis E virus (HEV) infection postdonation, complicating his recovery. The donor was a 28-year-old male with no prior health issues who underwent a right lobe hepatectomy. Initially, his postoperative course was uneventful, but on the third postoperative day, he became lethargic and icteric. Laboratory tests showed elevated liver function markers, with peak levels on the 5th day. The HEV infection was confirmed through serological and polymerase chain reaction (PCR) testing...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38512052/fascia-iliaca-catheters-for-donor-site-pain-after-split-thickness-skin-grafting-for-acute-burn-injury-a-retrospective-review
#16
JOURNAL ARTICLE
Usha Saldanha, Robin Aldwinkle, Amy Chen, Snehal Raut, Deepthi Penta, Yakelin Arroyo Valazquez, Soman Sen
The management of acute burn pain poses significant challenges. Regional techniques have become increasingly popular in perioperative burn pain management. Continuous nerve block catheters are particularly useful for split thickness skin grafts where donor site pain can exceed that of the burn-injured site. Donor skin is frequently harvested from the anterolateral thigh. The fascia iliaca (FI) compartment block provides blockade of both the lateral femoral cutaneous nerve and the femoral nerve and thus, it is a useful modality for burn donor pain...
March 21, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://read.qxmd.com/read/38511987/successful-anesthesia-management-of-pediatric-living-donor-liver-transplant-with-mild-bilateral-pulmonary-artery-stenosis-due-to-alagille-syndrome-a-case-report
#17
Nedim Çekmen, Ahmed Uslu, Adnan Torgay, Coşkun Araz, Emre Karakaya, Sedat Yildirim, Kürşad Tokel, Mehmet Haberal
Alagille syndrome is an autosomal-dominantinherited disease characterized by intrahepatic bile duct involvement, congenital heart disease, eye anomalies, skeletal and central nervous system involvement, kidney anomalies, and facial appearance. Liver transplant is the only treatment option for patients with end-stage liver disease and Alagille syndrome. Bilateral peripheral pulmonary artery stenosis is a contraindication for liver transplant due to high mortality, and the decision for liver transplant in patients with bilateral peripheral pulmonary artery stenosis is extremely challenging for anesthesiologists andtransplant surgeons...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511980/renal-transplant-in-elderly-end-stage-renal-disease-patients-impact-of-comorbidities-and-posttransplant-adverse-events-on-outcomes
#18
JOURNAL ARTICLE
Mohamed Yehia Hamdy, Hayam El Aggan, Iman El Gohary, Ahmed Halawa
OBJECTIVES: Elderly renal transplant continues to be debated because of age-related factors affecting transplant success and long-term prognosis. We investigated the effects ofrecipient age and predictors of renal transplant outcomes in elderly renal transplant recipients. MATERIALS AND METHODS: We retrospectively analyzed 506 patients who had a first renal transplant between January 2010 and December 2020; there were 165 recipients aged ≥60 years (elderly) and 341 recipients aged <60 years (young)...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511979/an-overview-of-liver-transplantation-current-status-recent-techniques-and-challenges-perspectives-from-a-center-in-china
#19
REVIEW
Zhihong Zheng, Lijin Zhao
Liver transplantation is the best way to treat end-stage liver disease.With benefits from enhanced techniques, refined management, and advanced medications, liver transplant boasts a commendable 5-year survival rate for recipients. Nevertheless, acquiring the perioperative management and surgical skills essential for liver transplant is a time-consuming process for new surgeons. In addition, COVID-19 has also affected the field. Based on our actual situation in China, we have provided an overview of donor evaluation,recipient selection,transplant procedures, postoperative complications and management, longterm management, and pandemic strategies to guide new clinical surgeons in the field...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38510332/reconstruction-of-plantar-forefoot-area-with-lateral-toe-pulp-flap-case-report-and-literature-review
#20
Chen-Ting Hung, Jiunn-Tat Lee, Meng-Si Wu, Li-Fu Cheng
Reconstruction of the plantar forefoot area is challenging because it performs important functions, including carrying the body weight and balancing the ambulation gait, and lacks similar skin and soft tissues to manage the adjacent region. Herein, we shared our experience of using a lateral toe pulp flap and reviewed the relevant literature on this topic. A 33-year-old man presented with a large granuloma in the left plantar forefoot area after undergoing multiple operations owing to the diagnosis of callus...
March 2024: Plastic and Reconstructive Surgery. Global Open
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