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https://www.readbyqxmd.com/read/27933728/sequential-change-detection-and-monitoring-of-temporal-trends-in-random-effects-meta-analysis
#1
Samson Henry Dogo, Allan Clark, Elena Kulinskaya
Temporal changes in magnitude of effect sizes reported in many areas of research are a threat to the credibility of the results and conclusions of meta-analysis. Numerous sequential methods for meta-analysis have been proposed to detect changes and monitor trends in effect sizes so that meta-analysis can be updated when necessary and interpreted based on the time it was conducted. The difficulties of sequential meta-analysis under the random-effects model are caused by dependencies in increments introduced by the estimation of the heterogeneity parameter τ(2) ...
December 8, 2016: Research Synthesis Methods
https://www.readbyqxmd.com/read/27933717/mass-cytometry-analytical-approaches-reveal-cytokine-induced-changes-in-natural-killer-cells
#2
Elena Vendrame, Julia Fukuyama, Dara M Strauss-Albee, Susan Holmes, Catherine A Blish
BACKGROUND: Natural killer (NK) cells have antiviral and antitumor activity that could be harnessed for the treatment of infections and malignancies. To maintain cell viability and enhance antiviral and antitumor effects, NK cells are frequently treated with cytokines. Here we performed an extensive assessment of the effects of cytokines on the phenotype and function of human NK cells. METHODS: We used cytometry by time-of-flight (CyTOF) to evaluate NK cell repertoire changes after stimulation with interleukin (IL)-2, IL-15 or a combination of IL- 12/IL-15/IL-18...
December 9, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27933711/using-a-co-production-prioritization-exercise-involving-south-asian-children-young-people-and-their-families-to-identify-health-priorities-requiring-further-research-and-public-awareness
#3
Logan Manikam, Rakhee Shah, Kate Reed, Gupreet Santini, Monica Lakhanpaul
OBJECTIVES: To facilitate South Asian (SA) families and health-care professionals (HCPs) participation in a prioritization exercise to co-produce child health research and public awareness agendas. DESIGN: A three-stage process was adopted involving the following: (i) systematic literature review, (ii) HCP scoping survey and (iii) focus groups of SA adolescents and families. A Punjabi- and Urdu-speaking community facilitator moderated focus groups. A British Sign Language interpreter assisted in the hard of hearing group...
December 8, 2016: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/27933554/use-of-anticoagulant-rodenticides-by-pest-management-professionals-in-massachusetts-usa
#4
Kristin Memmott, Maureen Murray, Allen Rutberg
Secondary exposure to chemical rodenticides, specifically second-generation anticoagulant rodenticides (SGARs), poses a threat to non-target wildlife including birds of prey. Federal regulations in the United States currently limit homeowner access to SGARs as a way of minimizing this threat. With legal access to SGARs, pest management professionals (PMPs) represent a potential linkage to non-target exposure. There is limited research focused on rodent control practices, chemical rodenticide preferences, level of concern and awareness, or opinions on rodenticide regulations as they relate to PMPs...
December 8, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27933545/the-collaborative-cross-resource-for-systems-genetics-research-of-infectious-diseases
#5
Paul L Maurizio, Martin T Ferris
An increasing body of evidence highlights the role of host genetic variation in driving susceptibility to severe disease following pathogen infection. In order to fully appreciate the importance of host genetics on infection susceptibility and resulting disease, genetically variable experimental model systems should be employed. These systems allow for the identification, characterization, and mechanistic dissection of genetic variants that cause differential disease responses. Herein we discuss application of the Collaborative Cross (CC) panel of recombinant inbred strains to study viral pathogenesis, focusing on practical considerations for experimental design, assessment and analysis of disease responses within the CC, as well as some of the resources developed for the CC...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933489/patients-understanding-and-use-of-analgesia-for-postnatal-pain-following-hospital-discharge
#6
Antonia M W Wong, Syed Tabish R Zaidi
Background Postnatal pain is one of the limiting factors in the recovery of women from child birth. Despite the routine prescribing of analgesics for postnatal pain, limited research is available on the use of analgesics by the women in postnatal period. Objective To measure the utilisation and effectiveness of prescribed oral analgesics, the incidence and severity of pain, and factors associated with poor pain control on the fifth-day post-hospital discharge in postnatal women. Setting A tertiary referral women's hospital of Western Australia...
December 9, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27933467/osteosarcoma-overview
#7
REVIEW
Brock A Lindsey, Justin E Markel, Eugenie S Kleinerman
Osteosarcoma (OS) is the most common primary malignancy of bone and patients with metastatic disease or recurrences continue to have very poor outcomes. Unfortunately, little prognostic improvement has been generated from the last 20 years of research and a new perspective is warranted. OS is extremely heterogeneous in both its origins and manifestations. Although multiple associations have been made between the development of osteosarcoma and race, gender, age, various genomic alterations, and exposure situations among others, the etiology remains unclear and controversial...
December 8, 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27933461/factors-associated-with-hiv-testing-among-participants-from-substance-use-disorder-treatment-programs-in-the-us-a-machine-learning-approach
#8
Yue Pan, Hongmei Liu, Lisa R Metsch, Daniel J Feaster
HIV testing is the foundation for consolidated HIV treatment and prevention. In this study, we aim to discover the most relevant variables for predicting HIV testing uptake among substance users in substance use disorder treatment programs by applying random forest (RF), a robust multivariate statistical learning method. We also provide a descriptive introduction to this method for those who are unfamiliar with it. We used data from the National Institute on Drug Abuse Clinical Trials Network HIV testing and counseling study (CTN-0032)...
December 8, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27933450/effects-of-exercise-intervention-in-breast-cancer-patients-is-mobile-health-mhealth-with-pedometer-more-effective-than-conventional-program-using-brochure
#9
Kyeong Eun Uhm, Ji Sung Yoo, Seung Hyun Chung, Jong Doo Lee, Ilkyun Lee, Joong Il Kim, Se Kyung Lee, Seok Jin Nam, Yong Hyun Park, Ji Youl Lee, Ji Hye Hwang
PURPOSE: To investigate and compare the effects of mobile health (mHealth) and pedometer with conventional exercise program using a brochure on physical function and quality of life (QOL). METHODS: The study was a prospective, quasi-randomized multicenter trial where 356 patients whose cancer treatment had been terminated were enrolled. All patients were instructed to perform a 12-week regimen of aerobic and resistance exercise. The mHealth group received a pedometer and a newly developed smartphone application to provide information and monitor the prescribed exercises...
December 8, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27933407/simvascular-an-open-source-pipeline-for-cardiovascular-simulation
#10
REVIEW
Adam Updegrove, Nathan M Wilson, Jameson Merkow, Hongzhi Lan, Alison L Marsden, Shawn C Shadden
Patient-specific cardiovascular simulation has become a paradigm in cardiovascular research and is emerging as a powerful tool in basic, translational and clinical research. In this paper we discuss the recent development of a fully open-source SimVascular software package, which provides a complete pipeline from medical image data segmentation to patient-specific blood flow simulation and analysis. This package serves as a research tool for cardiovascular modeling and simulation, and has contributed to numerous advances in personalized medicine, surgical planning and medical device design...
December 8, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27933305/robust-generation-of-transgenic-mice-by-simple-hypotonic-solution-mediated-delivery-of-transgene-in-testicular-germ-cells
#11
Abul Usmani, Nirmalya Ganguli, Subodh K Jain, Nilanjana Ganguli, Rajesh Kumar Sarkar, Mayank Choubey, Mansi Shukla, Hironmoy Sarkar, Subeer S Majumdar
Our ability to decipher gene sequences has increased enormously with the advent of modern sequencing tools, but the ability to divulge functions of new genes have not increased correspondingly. This has caused a remarkable delay in functional interpretation of several newly found genes in tissue and age specific manner, limiting the pace of biological research. This is mainly due to lack of advancements in methodological tools for transgenesis. Predominantly practiced method of transgenesis by pronuclear DNA-microinjection is time consuming, tedious, and requires highly skilled persons for embryo-manipulation...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/27933267/a-mixed-method-study-of-the-efficacy-of-physical-activity-consultation-as-an-adjunct-to-standard-smoking-cessation-treatment-among-male-smokers-in-malaysia
#12
Yuin Yi Lee, Selina Khoo, Tony Morris, Clare Hanlon, Lei-Hum Wee, Eng Wah Teo, Yuhanis Adnan
BACKGROUND: This study examined the effectiveness of using Physical Activity Consultation (PAC) as an addition to the standard smoking cessation treatment in Malaysia. We explored participants' experiences in terms of physical activity and smoking abstinence with the combined PAC and smoking cessation intervention. METHODS: Walk-in smokers from a local smoking cessation clinic volunteered for the 8-week intervention program, while undergoing standard smoking cessation treatment...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933257/assessment-of-the-quality-of-groundwater-for-drinking-purposes-in-the-upper-west-and-northern-regions-of-ghana
#13
Sixtus Bieranye Bayaa Martin Saana, Samuel Asiedu Fosu, Godfred Etsey Sebiawu, Napoleon Jackson, Thomas Karikari
BACKGROUND: Underground water is an important natural resource serving as a reliable source of drinking water for many people worldwide, especially in developing countries. Underground water quality needs to be given a primary research and quality control attention due to possible contamination. This study was therefore designed to determine the physico-chemical and bacteriological quality of borehole water in the Upper West and Northern regions of Ghana. METHODS: The study was conducted in seven districts in Ghana (including six in the Upper West region and one in the Northern region)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933251/robust-image-hashing-using-ring-partition-pgnmf-and-local-features
#14
Ram Kumar Karsh, R H Laskar, Bhanu Bhai Richhariya
BACKGROUND: Image authentication is one of the challenging research areas in the multimedia technology due to the availability of image editing tools. Image hash may be used for image authentication which should be invariant to perceptually similar image and sensitive to content changes. The challenging issue in image hashing is to design a system which simultaneously provides rotation robustness, desirable discrimination, sensitivity and localization of forged area with minimum hash length...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933243/model-based-extended-quaternion-kalman-filter-to-inertial-orientation-tracking-of-arbitrary-kinematic-chains
#15
Agnieszka Szczęsna, Przemysław Pruszowski
Inertial orientation tracking is still an area of active research, especially in the context of out-door, real-time, human motion capture. Existing systems either propose loosely coupled tracking approaches where each segment is considered independently, taking the resulting drawbacks into account, or tightly coupled solutions that are limited to a fixed chain with few segments. Such solutions have no flexibility to change the skeleton structure, are dedicated to a specific set of joints, and have high computational complexity...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933181/what-are-the-pros-and-cons-of-electronically-monitoring-inhaler-use-in-asthma-a-multistakeholder-perspective
#16
Sam Howard, Alexandra Lang, Sarah Sharples, Dominick Shaw
INTRODUCTION: Electronic monitoring devices (EMDs) are the optimal method for collecting objective data on inhaler use in asthma. Recent research has investigated the attitudes of patients with asthma towards these devices. However, no research to date has formally considered the opinions of stakeholders and decision-makers in asthma care. These individuals have important clinical requirements that need to be taken into account if EMDs are to be successfully provisioned, making collecting their opinions on the key barriers facing these devices a valuable process...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27933154/improving-diagnosis-for-congenital-cataract-by-introducing-ngs-genetic-testing
#17
Mohammud Musleh, Jane Ashworth, Graeme Black, Georgina Hall
Childhood cataract (CC) has an incidence of 3.5 per 10,000 by age 15 years. Diagnosis of any underlying cause is important to ensure effective and prompt management of multisystem complications, to facilitate accurate genetic counselling and to streamline multidisciplinary care. Next generation sequencing (NGS) has been shown to be effective in providing an underlying diagnosis in 70% of patients with CC in a research setting. This project aimed to integrate NGS testing in CC within six months of presentation and increase the rate of diagnosis...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27933103/programmatic-conversion-of-crystal-structures-into-3d-printable-files-using-jmol
#18
Vincent F Scalfani, Antony J Williams, Valery Tkachenko, Karen Karapetyan, Alexey Pshenichnov, Robert M Hanson, Jahred M Liddie, Jason E Bara
BACKGROUND: Three-dimensional (3D) printed crystal structures are useful for chemistry teaching and research. Current manual methods of converting crystal structures into 3D printable files are time-consuming and tedious. To overcome this limitation, we developed a programmatic method that allows for facile conversion of thousands of crystal structures directly into 3D printable files. RESULTS: A collection of over 30,000 crystal structures in crystallographic information file (CIF) format from the Crystallography Open Database (COD) were programmatically converted into 3D printable files (VRML format) using Jmol scripting...
2016: Journal of Cheminformatics
https://www.readbyqxmd.com/read/27933073/mistletoe-berry-outline-mapping-with-a-path-curve-function-and-recording-the-circadian-rhythm-of-their-phenotypic-shape-change
#19
Renatus Derbidge, Stephan Baumgartner, Peter Heusser
This paper presents a discovery: the change of the outline shape of mistletoe (Viscum album ssp. album) berries in vivo and in situ during ripening. It was found that a plant organ that is usually considered to merely increase in size actually changes shape in a specific rhythmic fashion. We introduce a new approach to chronobiological research on a macro-phenotypic scale to trace changes over long periods of time (with a resolution from hours to months) by using a dynamic form-determining parameter called Lambda (λ)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27933028/autism-in-action-reduced-bodily-connectedness-during-social-interactions
#20
C Lieke E Peper, Sija J van der Wal, Sander Begeer
Autism is a lifelong disorder, defined by deficits in social interactions and flexibility. To date, diagnostic markers for autism primarily include limitations in social behavior and cognition. However, such tests have often shown to be inadequate for individuals with autism who are either more cognitively able or intellectually disabled. The assessment of the social limitations of autism would benefit from new tests that capture the dynamics of social initiative and reciprocity in interaction processes, and that are not dependent on intellectual or verbal skills...
2016: Frontiers in Psychology
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