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https://www.readbyqxmd.com/read/29037005/stroke-epidemiology-in-south-east-and-south-east-asia-a-review
#1
REVIEW
Narayanaswamy Venketasubramanian, Byung Woo Yoon, Jeyaraj Pandian, Jose C Navarro
Asia, which holds 60% of the world's population, comprises some developing countries which are in economic transition. This paper reviews the epidemiology of stroke in South, East and South-East Asia. Data on the epidemiology of stroke in South, East, and South-East Asia were derived from the Global Burden of Disease study (mortality, disability-adjusted life-years [DALYs] lost because of stroke), World Health Organization (vascular risk factors in the community), and publications in PubMed (incidence, prevalence, subtypes, vascular risk factors among hospitalized stroke patients)...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29036887/reference-intervals-for-non-fasting-cvd-lipids-and-inflammation-markers-in-pregnant-indigenous-australian-women
#2
Tracy L Schumacher, Christopher Oldmeadow, Don Clausen, Loretta Weatherall, Lyniece Keogh, Kirsty G Pringle, Kym M Rae
Indigenous Australians experience high rates of cardiovascular disease (CVD). The origins of CVD may commence during pregnancy, yet few serum reference values for CVD biomarkers exist specific to the pregnancy period. The Gomeroi gaaynggal research project is a program that undertakes research and provides some health services to pregnant Indigenous women. Three hundred and ninety-nine non-fasting samples provided by the study participants (206 pregnancies and 175 women) have been used to construct reference intervals for CVD biomarkers during this critical time...
October 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29036884/recent-advances-in-mycotoxin-determination-for-food-monitoring-via-microchip
#3
REVIEW
Yan Man, Gang Liang, An Li, Ligang Pan
Mycotoxins are one of the main factors impacting food safety. Mycotoxin contamination has threatened the health of humans and animals. Conventional methods for the detection of mycotoxins are gas chromatography (GC) or liquid chromatography (LC) coupled with mass spectrometry (MS), or enzyme-linked immunosorbent assay (ELISA). However, all these methods are time-consuming, require large-scale instruments and skilled technicians, and consume large amounts of hazardous regents and solvents. Interestingly, a microchip requires less sample consumption and short analysis time, and can realize the integration, miniaturization, and high-throughput detection of the samples...
October 14, 2017: Toxins
https://www.readbyqxmd.com/read/29036877/a-hybrid-cnn-feature-model-for-pulmonary-nodule-malignancy-risk-differentiation
#4
Huafeng Wang, Tingting Zhao, Lihong Connie Li, Haixia Pan, Wanquan Liu, Haoqi Gao, Fangfang Han, Yuehai Wang, YiFang Qi, Zhengrong Liang
The malignancy risk differentiation of pulmonary nodule is one of the most challenge tasks of computer-aided diagnosis (CADx). Most recently reported CADx methods or schemes based on texture and shape estimation have shown relatively satisfactory on differentiating the risk level of malignancy among the nodules detected in lung cancer screening. However, the existing CADx schemes tend to detect and analyze characteristics of pulmonary nodules from a statistical perspective according to local features only. Enlightened by the currently prevailing learning ability of convolutional neural network (CNN), which simulates human neural network for target recognition and our previously research on texture features, we present a hybrid model that takes into consideration of both global and local features for pulmonary nodule differentiation using the largest public database founded by the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI)...
October 10, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29036869/the-relationship-between-trait-self-control-consideration-for-future-consequence-and-organizational-citizenship-behavior-among-chinese-employees
#5
Yu-Jie Wang, Kai Dou
BACKGROUND: Organizational citizenship behavior (OCB) is important to the development of an organization. Research into factors that foster OCB and the underlying processes are therefore substantially crucial. OBJECTIVE: The current study aimed to test the association between trait self-control and OCB and the mediating role of consideration for future consequence. METHOD: Four hundred and ninety-four Chinese employees (275 men, 219 women) took part in the study...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036845/sexual-concerns-after-spinal-cord-injury-an-update-on-management
#6
Marcalee Sipski Alexander, Carrie Mlynarczyk Aisen, Sterling Morrison Alexander, Mindy Lipson Aisen
BACKGROUND: Spinal Cord Injury (SCI) causes neurological impairment with resultant neurogenic sexual dysfunction which can compound preexisting psychological and medical sexual concerns. Understanding these concerns is important in managing the lifelong needs of persons with SCIs. OBJECTIVES: To provide an overview of the impact of SCI on sexuality along with a framework for treatment of sexual concerns. To briefly review male infertility and its treatments and pregnancy in females after SCI...
October 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036726/contribution-of-different-particles-measured-with-track-etched-detectors-onboard-iss
#7
I Ambrožová, M Davídková, K Pachnerová Brabcová, R V Tolochek, V A Shurshakov
Cosmic radiation consists of primary high-energy galactic and solar particles. When passing through spacecraft walls and astronauts' bodies, the spectrum becomes even more complex due to generating of secondary particles through fragmentation and nuclear interactions. Total radiation exposure is contributed by both these components. With an advantage, space research uses track etched detectors from the group of passive detectors visualizing the tracks of particles, in this case by etching. The detectors can discriminate between various components of cosmic radiation...
September 29, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036714/accounting-for-technical-noise-in-differential-expression-analysis-of-single-cell-rna-sequencing-data
#8
Cheng Jia, Yu Hu, Derek Kelly, Junhyong Kim, Mingyao Li, Nancy R Zhang
Recent technological breakthroughs have made it possible to measure RNA expression at the single-cell level, thus paving the way for exploring expression heterogeneity among individual cells. Current single-cell RNA sequencing (scRNA-seq) protocols are complex and introduce technical biases that vary across cells, which can bias downstream analysis without proper adjustment. To account for cell-to-cell technical differences, we propose a statistical framework, TASC (Toolkit for Analysis of Single Cell RNA-seq), an empirical Bayes approach to reliably model the cell-specific dropout rates and amplification bias by use of external RNA spike-ins...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036693/icg-a-wiki-driven-knowledgebase-of-internal-control-genes-for-rt-qpcr-normalization
#9
Jian Sang, Zhennan Wang, Man Li, Jiabao Cao, Guangyi Niu, Lin Xia, Dong Zou, Fan Wang, Xingjian Xu, Xiaojiao Han, Jinqi Fan, Ye Yang, Wanzhu Zuo, Yang Zhang, Wenming Zhao, Yiming Bao, Jingfa Xiao, Songnian Hu, Lili Hao, Zhang Zhang
Real-time quantitative PCR (RT-qPCR) has become a widely used method for accurate expression profiling of targeted mRNA and ncRNA. Selection of appropriate internal control genes for RT-qPCR normalization is an elementary prerequisite for reliable expression measurement. Here, we present ICG (http://icg.big.ac.cn), a wiki-driven knowledgebase for community curation of experimentally validated internal control genes as well as their associated experimental conditions. Unlike extant related databases that focus on qPCR primers in model organisms (mainly human and mouse), ICG features harnessing collective intelligence in community integration of internal control genes for a variety of species...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036687/measuring-deaminated-nucleotide-surveillance-enzyme-itpa-activity-with-an-atp-releasing-nucleotide-chimera
#10
Debin Ji, Elena I Stepchenkova, Jian Cui, Miriam R Menezes, Youri I Pavlov, Eric T Kool
Nucleotide quality surveillance enzymes play important roles in human health, by detecting damaged molecules in the nucleotide pool and deactivating them before they are incorporated into chromosomal DNA or adversely affect metabolism. In particular, deamination of adenine moiety in (deoxy)nucleoside triphosphates, resulting in formation of (d)ITP, can be deleterious, leading to DNA damage, mutagenesis and other harmful cellular effects. The 21.5 kDa human enzyme that mitigates this damage by conversion of (d)ITP to monophosphate, ITPA, has been proposed as a possible therapeutic and diagnostic target for multiple diseases...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036627/using-uncertainty-to-link-and-rank-evidence-from-biomedical-literature-for-model-curation
#11
Chrysoula Zerva, Riza Batista-Navarro, Philip Day, Sophia Ananiadou
Motivation: In recent years, there has been great progress in the field of automated curation of biomedical networks and models, aided by text mining methods that provide evidence from literature. Such methods must not only extract snippets of text that relate to model interactions, but also be able to contextualize the evidence and provide additional confidence scores for the interaction in question. Although various approaches calculating confidence scores have focused primarily on the quality of the extracted information, there has been little work on exploring the textual uncertainty conveyed by the author...
July 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036616/deeploc-prediction-of-protein-subcellular-localization-using-deep-learning
#12
José Juan Almagro Armenteros, Casper Kaae Sønderby, Søren Kaae Sønderby, Henrik Nielsen, Ole Winther
Motivation: The prediction of eukaryotic protein subcellular localization is a well-studied topic in bioinformatics due to its relevance in proteomics research. Many machine learning methods have been successfully applied in this task, but in most of them, predictions rely on annotation of homologues from knowledge databases. For novel proteins where no annotated homologues exist, and for predicting the effects of sequence variants, it is desirable to have methods for predicting protein properties from sequence information only...
July 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036497/forecasting-residue-residue-contact-prediction-accuracy
#13
P P Wozniak, B M Konopka, J Xu, G Vriend, M Kotulska
Motivation: Apart from meta-predictors, most of today's methods for residue-residue contact prediction are based entirely on Direct Coupling Analysis (DCA) of correlated mutations in multiple sequence alignments (MSAs). These methods are on average ∼40% correct for the 100 strongest predicted contacts in each protein. The end-user who works on a single protein of interest will not know if predictions are either much more or much less correct than 40%, which is especially a problem if contacts are predicted to steer experimental research on that protein...
June 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036421/lrcstats-a-tool-for-evaluating-long-reads-correction-methods
#14
Sean La, Ehsan Haghshenas, Cedric Chauve
Motivation: Third-generation sequencing (TGS) platforms that generate long reads, such as PacBio and Oxford Nanopore technologies, have had a dramatic impact on genomics research. However, despite recent improvements, TGS reads suffer from high-error rates and the development of read correction methods is an active field of research. This motivates the need to develop tools that can evaluate the accuracy of noisy long reads correction tools. Results: We introduce LRCstats, a tool that measures the accuracy of long reads correction tools...
August 2, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036302/a-prospective-observational-study-to-investigate-utility-of-the-delirium-observational-screening-scale-doss-to-detect-delirium-in-care-home-residents
#15
E A Teale, T Munyombwe, M Schuurmans, N Siddiqi, J Young
Background: care home residents are particularly at risk of delirium due to high prevalence of dementia. The Delirium Observation Screening Scale (DOSS) identifies behavioural changes associated delirium onset that nursing staff are uniquely placed to recognise. We tested the psychometric properties of the DOSS in UK care homes compared with the Confusion Assessment Method (CAM). Design: prospective observational cohort study performed between 1 March 2015 and 30 June 2016...
October 5, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29036214/the-fate-of-endemic-insects-of-the-andean-region-under-the-effect-of-global-warming
#16
Sara I Montemayor, María Cecilia Melo, María Celeste Scattolini, Martina E Pocco, María Guadalupe Del Río, Gimena Dellapé, Erica E Scheibler, Sergio A Roig, Carla G Cazorla, Pablo M Dellapé
Three independent but complementary lines of research have provided evidence for the recognition of refugia: paleontology, phylogeography and species distributional modelling (SDM). SDM assesses the ecological requirements of a species based on its known occurrences and enables its distribution to be projected on past climatological reconstructions. One advantage over the other two approaches is that it provides an explicit link to environment and geography, thereby enabling the analysis of a large number of taxa in the search for more general refugia patterns...
2017: PloS One
https://www.readbyqxmd.com/read/29036191/men-ask-more-questions-than-women-at-a-scientific-conference
#17
Amy Hinsley, William J Sutherland, Alison Johnston
Gender inequity in science and academia, especially in senior positions, is a recognised problem. The reasons are poorly understood, but include the persistence of historical gender ratios, discrimination and other factors, including gender-based behavioural differences. We studied participation in a professional context by observing question-asking behaviour at a large international conference with a clear equality code of conduct that prohibited any form of discrimination. Accounting for audience gender ratio, male attendees asked 1...
2017: PloS One
https://www.readbyqxmd.com/read/29036149/bandwidth-correction-in-the-spectral-measurement-of-light-emitting-diodes
#18
S Q Jin, C Huang, G Xia, M Y Hu, Z J Liu
Light-emitting diodes (LEDs) are widely employed in industrial applications and scientific research. However, spectral distortions will occur due to the broadening effects of the spectrometer when an LED spectrum is obtained with a spectrometer. In this paper, a novel approach is put forward to correct bandwidth for an LED spectrum based on a Levenberg-Marquardt algorithm and He-Zheng model. We compare estimation errors of different LED spectra by using the proposed method along with the Richardson-Lucy method and differential operator approach...
September 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29036125/automatic-classification-of-atherosclerotic-tissue-in-intravascular-optical-coherence-tomography-images
#19
Ping Zhou, Tongjing Zhu, Chunliu He, Zhiyong Li
Intravascular optical coherence tomography (IVOCT) has been successfully utilized for in vivo diagnostics of coronary plaques. However, classification of atherosclerotic tissues is mainly performed manually by experienced experts, which is time-consuming and subjective. To overcome these limitations, an automatic method of segmentation and classification of IVOCT images is developed in this paper. The method is capable of detecting the plaque contour between the fibrous tissues and other components. Subsequently, the method classifies the tissues based on their texture features described by Fourier transform and discrete wavelet transform...
July 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29036017/patient-reported-outcomes-in-asthma-clinical-trials
#20
Fulvio Braido, Ilaria Baiardini, Giorgio W Canonica
PURPOSE OF REVIEW: The review provides an overview of the results of asthma clinical trials published in peer review journals in the last 18 months that evaluated patient-reported outcomes (PROs). RECENT FINDINGS: In the last 10 years, health care moved toward a patient-centered approach, which includes patients' perspectives reflecting the impact of a disease and its treatment. SUMMARY: Surprisingly, among the almost 300 clinical trials published in the last one and a half year, PRO evaluation was performed in only 20 studies, and none of them held in a real-life setting...
October 13, 2017: Current Opinion in Pulmonary Medicine
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