keyword
https://read.qxmd.com/read/38547392/rheumatoid-arthritis-patients-perspective-on-the-use-of-prediction-models-in-clinical-decision-making
#21
JOURNAL ARTICLE
Marianne A Messelink, Sina Fadaei, Lise M Verhoef, Paco Welsing, Nienke C Nijhof, Heleen Westland
OBJECTIVES: A rapidly expanding number of prediction models is being developed aiming to improve rheumatoid arthritis (RA) diagnosis and treatment. However, few are actually implemented in clinical practice. This study explores factors influencing the acceptance of prediction models in clinical decision-making by RA patients. METHODS: A qualitative study design was used with thematic analysis of semi-structured interviews. Purposive sampling was applied to capture a complete overview of influencing factors...
March 28, 2024: Rheumatology
https://read.qxmd.com/read/38547391/tumor-infiltrating-lymphocytes-and-breast-cancer-mortality-in-racially-and-ethnically-diverse-participants-of-the-northern-california-breast-cancer-family-registry
#22
JOURNAL ARTICLE
Julia D Ransohoff, Iain Miller, Jocelyn Koo, Vishal Joshi, Allison W Kurian, Kimberly H Allison, Esther M John, Melinda L Telli
Stromal tumor-infiltrating lymphocyte (sTIL) enrichment in pre-treatment breast tumors has been associated with superior response to neoadjuvant treatment and survival. In a population-based cohort, we studied sTIL-survival associations by race and ethnicity. We assessed associations of continuous sTIL scores and sTIL-enriched breast cancers (defined as percent lymphocytic infiltration of tumor stroma or cell nests at cutoffs of 30%, 50%, and 70%) with clinical and epidemiologic characteristics and conducted multivariable survival analyses...
March 28, 2024: JNCI Cancer Spectrum
https://read.qxmd.com/read/38547389/clinical-and-radiological-septic-joint-analysis-of-spontaneous-sternoclavicular-joint-infections-achieving-the-best-outcomes-a-systems-engineering-approach
#23
JOURNAL ARTICLE
Tanushri Pothini, Charles D Wilmot, John K Waters, Michael A Wait, Scott I Reznik, Kirk G Jordan, Jacqueline T Caire, John M Ashworth, Leah C Cady, Jerzy R Lysikowski, Christina F Yen, Robert C Weinschenk, Richard Samade, Michael E Jessen, Andrew Kusiak, Kemp H Kernstine
PURPOSE: Spontaneous sternoclavicular joint infection (SSCJI) is a rare and poorly understood disease process. This study aims to identify factors guiding effective management strategies for SSCJI by using data mining. METHODS: An IRB-approved retrospective review of patients from two large hospitals (2010 to 2022) was conducted. Spontaneous sternoclavicular joint infection is defined as a joint infection without direct trauma or radiation, direct instrumentation, or contiguous spread...
March 28, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38547387/a-prospective-examination-of-the-interpersonal-psychological-theory-of-suicidal-behavior-in-adolescents
#24
JOURNAL ARTICLE
Cheryl A King, David Brent, Jacqueline Grupp-Phelan, Kent Page, Ewa Czyz, Taylor C McGuire, E Melinda Mahabee-Gittens, Lucy Block, T Charles Casper
OBJECTIVE: Given the large and complex array of suicide risk factors, theoretical frameworks are critical to furthering our understanding of risk. This study prospectively examined several key constructs of the interpersonal-psychological theory of suicidal behavior (IPTS) in a large, geographically diverse sample of U.S. adolescents. METHOD: Conducted in collaboration with the Pediatric Emergency Care Applied Research Network, adolescents, ages 12 to 17, were recruited from emergency departments...
March 28, 2024: Journal of Clinical Child and Adolescent Psychology
https://read.qxmd.com/read/38547381/precision-medicine-to-personalize-medicine-in-allergic-airway-disease
#25
JOURNAL ARTICLE
Jean Kim
PURPOSE OF REVIEW: The purpose of this study is to understand the approach to precision medicine and personalized medicine in the management of allergic airway disease. RECENT FINDINGS: Identification of biomarkers as key tools used in precision medicine has led to the development of multiple biologic drugs being used as new treatments for allergic airway disease. SUMMARY: In addition to these advances, there is still much needed effort to improve the feasibility and utility of integrating biologic omics data of precision medicine with physicochemical, behavioral, psychological, and social data to deliver optimized treatments that is personalized for each individual...
March 28, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38547334/noninvasive-assessment-of-liver-fibrosis-and-portal-hypertension
#26
JOURNAL ARTICLE
Andres Duarte-Rojo, Keyur Patel, Don C Rockey
PURPOSE OF REVIEW: The result of ongoing liver injury - and disease, regardless of cause - is fibrosis, and fibrosis appears to be a critically important result of ongoing injury. Further, in a number of different liver diseases, the presence of fibrosis has prognostic value. Therefore, the assessment of fibrosis is of critical clinical importance. Given the importance of fibrosis, there has been a rapid evolution in the use of noninvasive liver tests. This review highlights a number of the core principles surrounding...
March 29, 2024: Current Opinion in Gastroenterology
https://read.qxmd.com/read/38547333/update-on-ischemic-hepatitis
#27
JOURNAL ARTICLE
Jessica Elizabeth Smith, Don C Rockey
PURPOSE OF REVIEW: Ischemic hepatitis (IH) refers to diffuse liver injury secondary to hypoperfusion. The condition is usually seen in the critical care setting and is associated with significant mortality. IH typically occurs in the setting of systemic hypotension superimposed on some form of underlying cardiac dysfunction. This review aims to report what is known and what is new about the etiology, pathophysiology, and clinical features associated with IH. RECENT FINDINGS: In recent years, studies on IH have largely confirmed earlier reports regarding etiologies, comorbid conditions, and associated mortality...
March 18, 2024: Current Opinion in Gastroenterology
https://read.qxmd.com/read/38547331/circulating-factors-in-cancer-cachexia-recent-opportunities-for-translational-research
#28
JOURNAL ARTICLE
Marina de Castro Coêlho, Giovana Parreira de Aquino, Amanda Soares Santos, Marilia Seelaender
PURPOSE OF REVIEW: To discuss the recent discoveries and limitations of the available literature on emerging circulating biomarkers of cancer cachexia. RECENT FINDINGS: Studies on circulating factors in cancer cachexia show promising alternatives for diagnosing the syndrome in a minimally invasive manner in the clinic setting, as well as potential targets for cancer cachexia treatment. Factors secreted by the tumor and the adipose tissue, such as extracellular vesicles and soluble proteins, respectively, have been shown to either directly induce wasting in vitro and in vivo or to be altered in the cachectic phenotype...
March 27, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547329/monitoring-coeliac-disease-in-2024-time-to-change-practice
#29
JOURNAL ARTICLE
Suneil A Raju, Mohamed G Shiha, Hugo A Penny
PURPOSE OF REVIEW: Persistent villous atrophy is associated with morbidity in coeliac disease and most commonly due to ongoing gluten ingestion. Current methods for assessing gluten exposure and persisting villous atrophy include dietary questionnaires and repeat duodenal biopsy, which have limited accuracy or are invasive. This review discusses adjunctive and/or novel tests that could be used to overcome these challenges. RECENT FINDINGS: Small bowel capsule endoscopy is well tolerated and helps to evaluate for persisting villous atrophy and importantly, complications associated with coeliac disease...
March 14, 2024: Current Opinion in Gastroenterology
https://read.qxmd.com/read/38547325/inter-and-intraobserver-variability-on-endoscopic-scoring-systems-in-crohn-s-disease-and-ulcerative-colitis-a-systematic-review-and-meta-analysis
#30
JOURNAL ARTICLE
Jana G Hashash, Faye Yu Ci Ng, Francis A Farraye, Yeli Wang, Daniel R Colucci, Shrujal Baxi, Sadaf Muneer, Mitchell Reddan, Pratik Shingru, Gil Y Melmed
BACKGROUND: Endoscopy scoring is a key component in the diagnosis of ulcerative colitis (UC) and Crohn's disease (CD). Variability in endoscopic scoring can impact patient trial eligibility and treatment effect measurement. In this study, we examine inter- and intraobserver variability of inflammatory bowel disease endoscopic scoring systems in a systematic review and meta-analysis. METHODS: We included observational studies that evaluated the inter- and intraobserver variability using UC (endoscopic Mayo Score [eMS], Ulcerative Colitis Endoscopic Index of Severity [UCEIS]) or CD (Crohn's Disease Endoscopic Index of Severity [CDEIS], Simple Endoscopic Score for Crohn's Disease [SES-CD]) systems among adults (≥18 years of age) and were published in English...
March 28, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38547323/sarcopenic-obesity-and-the-impact-on-bone-health
#31
JOURNAL ARTICLE
Silvia Migliaccio, Edoardo Mocini, Marianna Minnetti, Lorenzo Maria Donini
PURPOSE OF THE REVIEW: Sarcopenic obesity is a newly identified pathological entity defined by an increase in body fat mass with an associated sarcopenia, characterized by loss of muscle mass, strength, and function. Recently, the concomitant presence of skeletal alteration with sarcopenic obesity has been described leading to a new clinical entity defined osteosarcopenic obesity (OSO). Many studies have tried to unravel the metabolic complex mechanism leading to this clinical entity in order to understand the pathophysiology of this complex condition with the aim of posing an early diagnosis to improve the therapeutic approaches...
March 20, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547316/chronic-viral-infection-impairs-immune-memory-to-a-different-pathogen
#32
JOURNAL ARTICLE
Cheng Yang, Zhicui Liu, Ying Yang, Luis J Cocka, Yongguo Li, Weihong Zeng, Hao Shen
Chronic viral infections cause T cell dysfunction in both animal models and human clinical settings, thereby affecting the ability of the host immune system to clear viral pathogens and develop proper virus-specific immune memory. However, the impact of chronic viral infections on the host's immune memory to other pathogens has not been well described. In this study, we immunized mice with recombinant Listeria monocytogenes expressing OVA (Lm-OVA) to generate immunity to Lm and allow analysis of OVA-specific memory T (Tm) cells...
March 28, 2024: PLoS Pathogens
https://read.qxmd.com/read/38547314/strongyloidiasis-in-auckland-a-ten-year-retrospective-study-of-diagnosis-treatment-and-outcomes-of-a-predominantly-polynesian-and-fijian-migrant-cohort
#33
JOURNAL ARTICLE
Tim Cutfield, Soana Karuna Motuhifonua, Matthew Blakiston, Hasan Bhally, Eamon Duffy, Rebekah Lane, Erik Otte, Terri Swager, Amanda Maree Taylor, Veronica Playle
BACKGROUND: Strongyloides stercoralis is not endemic in Aotearoa New Zealand (AoNZ). However, approximately one third of Auckland residents are born in endemic countries. This study aimed to describe the epidemiology and management of strongyloidiasis in Auckland, with a focus on migrants from Pacific Island Countries and Territories. METHODS: This study retrospectively reviewed clinical, laboratory and pharmacy records data for all people diagnosed with strongyloidiasis in the Auckland region between July 2012 and June 2022...
March 28, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38547309/identification-and-validation-of-key-mirnas-and-a-microrna-mrna-regulatory-network-associated-with-liver-cancer
#34
JOURNAL ARTICLE
Jie Tang, Song Li, Zixiao Zhou, Weicai Chang, Yongqiang Wang, Juan Mei, Shaobo Zhou
MiRNAs play crucial regulatory roles in the growth and development of tumor cells by serving as carriers of post-transcriptional regulatory information derived from genes. Investigating the potential function and clinical significance of miRNA-mediated mRNA regulatory networks in liver cancer can offer novel insights and therapeutic strategies for the treatment of this disease. We identified 300 differentially expressed miRNAs, and five miRNAs were identified to be correlated with overall survival and could be used as an independent prognostic...
March 28, 2024: Cell Cycle
https://read.qxmd.com/read/38547304/characterization-of-a-hemolytic-and-antibiotic-resistant-pseudomonas-aeruginosa-strain-s3-pathogenic-to-fish-isolated-from-mahananda-river-in-india
#35
JOURNAL ARTICLE
Dipanwita Ghosh, Preeti Mangar, Abhinandan Choudhury, Anoop Kumar, Aniruddha Saha, Protip Basu, Dipanwita Saha
Virulent strain Pseudomonas aeruginosa isolated from Mahananda River exhibited the highest hemolytic activity and virulence factors and was pathogenic to fish as clinical signs of hemorrhagic spots, loss of scales, and fin erosions were found. S3 was cytotoxic to the human liver cell line (WRL-68) in the trypan blue dye exclusion assay. Genotype characterization using whole genome analysis showed that S3 was similar to P. aeruginosa PAO1. The draft genome sequence had an estimated length of 62,69,783 bp, a GC content of 66...
2024: PloS One
https://read.qxmd.com/read/38547257/the-effect-of-real-time-ef-automatic-tool-on-cardiac-ultrasound-performance-among-medical-students
#36
JOURNAL ARTICLE
Noam Aronovitz, Itai Hazan, Roni Jedwab, Itamar Ben Shitrit, Anna Quinn, Oren Wacht, Lior Fuchs
PURPOSE: Point-of-care ultrasound (POCUS) is a sensitive, safe, and efficient tool used in many clinical settings and is an essential part of medical education in the United States. Numerous studies present improved diagnostic performances and positive clinical outcomes among POCUS users. However, others stress the degree to which the modality is user-dependent, rendering high-quality POCUS training necessary in medical education. In this study, the authors aimed to investigate the potential of an artificial intelligence (AI) based quality indicator tool as a teaching device for cardiac POCUS performance...
2024: PloS One
https://read.qxmd.com/read/38547254/a-clinically-attenuated-double-mutant-of-porcine-reproductive-and-respiratory-syndrome-virus-2-that-does-not-prompt-overexpression-of-proinflammatory-cytokines-during-co-infection-with-a-secondary-pathogen
#37
JOURNAL ARTICLE
Chia-Ming Su, Jineui Kim, Junyu Tang, Yu Fan Hung, Federico A Zuckermann, Robert Husmann, Patrick Roady, Jiyoun Kim, Young-Min Lee, Dongwan Yoo
Porcine reproductive and respiratory syndrome virus (PRRSV) is known to suppress the type I interferon (IFNs-α/β) response during infection. PRRSV also activates the NF-κB signaling pathway, leading to the production of proinflammatory cytokines during infection. In swine farms, co-infections of PRRSV and other secondary bacterial pathogens are common and exacerbate the production of proinflammatory cytokines, contributing to the porcine respiratory disease complex (PRDC) which is clinically a severe disease...
March 28, 2024: PLoS Pathogens
https://read.qxmd.com/read/38547239/the-causal-effect-of-iron-status-on-risk-of-anxiety-disorders-a-two-sample-mendelian-randomization-study
#38
JOURNAL ARTICLE
Ruiying Yin, Qi Gao, Guangzhen Fu, Qiang Zhao
OBJECTIVES: Observational studies had investigated the association of iron metabolism with anxiety disorders. The conclusions were inconsistent and not available to reveal the causal or reverse-causal association due to the confounding. In this study we estimated the potential causal effect of iron homeostasis markers on anxiety disorders using two-sample Mendelian randomization (MR) analysis. METHODS: Summary data of single nucleotide polymorphisms (SNPs) associated with four iron-related biomarkers were extracted from a recent report about analysis of three genome-wide association study (GWAS), the sample size of which ranged from 131471 to 246139 individuals...
2024: PloS One
https://read.qxmd.com/read/38547229/feasibility-of-using-low-cost-markerless-motion-capture-for-assessing-functional-outcomes-after-lower-extremity-musculoskeletal-cancer-surgery
#39
JOURNAL ARTICLE
Sherron Furtado, Brook Galna, Alan Godfrey, Lynn Rochester, Craig Gerrand
BACKGROUND: Physical limitations are frequent and debilitating after sarcoma treatment. Markerless motion capture (MMC) could measure these limitations. Historically expensive cumbersome systems have posed barriers to clinical translation. RESEARCH QUESTION: Can inexpensive MMC [using Microsoft KinectTM] assess functional outcomes after sarcoma surgery, discriminate between tumour sub-groups and agree with existing assessments? METHODS: Walking, unilateral stance and kneeling were measured in a cross-sectional study of patients with lower extremity sarcomas using MMC and standard video...
2024: PloS One
https://read.qxmd.com/read/38547222/factors-associated-with-hepatitis-a-susceptibility-among-men-who-have-sex-with-men-using-hiv-pre-exposure-prophylaxis-in-northeastern-brazil-a-cross-sectional-study
#40
JOURNAL ARTICLE
Hareton Teixeira Vechi, Mônica Baumgardt Bay, Cláudio Henrique Silva de Freitas, Júlia Gomes Fernandes Costa de Sant'anna, Carlos Brites, Kenio Costa de Lima
Hepatitis A virus (HAV) infection has disproportionately affected more men who have sex with men (MSM), occurring in outbreaks, despite being vaccine-preventable. We determined the prevalence and factors associated with HAV susceptibility among cisgender MSM on HIV pre-exposure prophylaxis (PrEP) in Northeastern Brazil. From September 30, 2021 to June 19, 2023, 282 cisgender MSM receiving HIV PrEP were enrolled into this cross-sectional study. Sociodemographic and clinical information were collected. Blood samples were collected for screening of sexually transmitted infections (STIs) and serum samples were tested for IgM and total anti-HAV antibodies...
2024: PloS One
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