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https://www.readbyqxmd.com/read/28351090/an-increase-in-normal-sua-level-within-the-normal-range-predicts-risk-of-metabolic-syndrome-especially-in-women-a-cross-sectional-study
#1
Qian Li, Jing Lu, Xi Cao, Ting-Ting Shi, Jian-Ping Feng, Jin-Kui Yang
This study was aimed to evaluate the relationship between normal serum uric acid (SUA) level and metabolic syndrome (MetS) risk. This cross-sectional study involved 1914 subjects with MetS and 3 659 healthy controls aged 18-79 years. All participants filled out questionnaires and underwent physical examination and blood sample collection for biochemical examination. Demographic and clinical characteristics data were analyzed by t-test or chi-squared test. Normal SUA levels were divided into quartiles. Associations between quartiles of normal SUA level and the risk of MetS were explored using logistic regression analysis and receiver operating characteristic (ROC) curve analysis...
March 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351086/independent-risk-factors-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma
#2
Xiaolong Yu, Xuejia Song, Wenhai Sun, Shihua Zhao, Jiajun Zhao, Yan-Gang Wang
The incidence of papillary thyroid microcarcinoma (PTMC) has risen rapidly in recent years, and PTMC patients with central lymph node metastasis (CLNM) usually have poor prognosis. Independent risk factors predicting CLNM in PTMC have not been well understood. The aim of our study was to identify useful clinicopathological risk factors predicting CLNM in PTMC patients. This was a retrospective study of 917 patients with PTMC treated with surgery from January 2014 to December 2015 in our hospital. The relationship between clinicopathological factors and CLNM was analyzed to identify those factors predicting CLNM in PTMC...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351006/variola-minor-in-coalfield-areas-of-england-and-wales-1921-34-geographical-determinants-of-a-national-smallpox-epidemic-that-spread-out-of-effective-control
#3
Matthew R Smallman-Raynor, Sarah Rafferty, Andrew D Cliff
This paper uses techniques of binary logistic regression to identify the spatial determinants of the last national epidemic of smallpox to spread in England and Wales, the variola minor epidemic of 1921-34. Adjusting for age and county-level variations in vaccination coverage in infancy, the analysis identifies a dose-response gradient with increasing odds of elevated smallpox rates in local government areas with (i) medium (odds ratio [OR] = 5.32, 95% Confidence Interval [95% CI] 1.96-14.41) and high (OR = 11...
March 23, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28350854/expression-of-claudin-11-23-in-different-gastric-tissues-and-its-relationship-with-the-risk-and-prognosis-of-gastric-cancer
#4
Youzhu Lu, Jingjing Jing, Liping Sun, Yuehua Gong, Moye Chen, Zeyang Wang, Mingjun Sun, Yuan Yuan
Claudins play an important role in regulating the permeability of epithelial and endothelial cells and in the maintenance of cell polarity. We aimed to investigate expression of claudin-11, -23 in different gastric tissues and its relationship with clinicopathologic parameters and prognosis of gastric cancer. We compared their expression levels in the paired cancerous tissues versus those in the adjacent noncancerous tissues by real-time PCR, western blotting and immunohistochemistry. The results showed that the expression of claudin-11, -23 was greatly increased in paracancerous gastric tissue compared with cancerous tissue...
2017: PloS One
https://www.readbyqxmd.com/read/28350839/bidirectional-association-between-nonalcoholic-fatty-liver-disease-and-type-2-diabetes-in-chinese-population-evidence-from-the-dongfeng-tongji-cohort-study
#5
Yaru Li, Jing Wang, Yuhan Tang, Xu Han, Bing Liu, Hua Hu, Xiulou Li, Kun Yang, Jing Yuan, Xiaoping Miao, Ping Yao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, An Pan, Handong Yang, Frank B Hu, Tangchun Wu, Meian He
OBJECTIVES: The aim of this study is to examine the bidirectional association between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). METHODS: The data was derived from the Dongfeng-Tongji cohort study, which was established in 2008 and followed until October 2013. NAFLD was classified as none, mild, moderate/severe based on ultrasound examination. The analysis to examine the association between NAFLD and incident T2DM risk included 18,111 participants free of diabetes at baseline and the duration of follow-up was 4...
2017: PloS One
https://www.readbyqxmd.com/read/28350831/post-term-growth-and-cognitive-development-at-5-years-of-age-in-preterm-children-evidence-from-a-prospective-population-based-cohort
#6
Laure Simon, Simon Nusinovici, Cyril Flamant, Bertrand Cariou, Valérie Rouger, Géraldine Gascoin, Dominique Darmaun, Jean-Christophe Rozé, Matthieu Hanf
While the effects of growth from birth to expected term on the subsequent development of preterm children has attracted plentiful attention, less is known about the effects of post-term growth. We aimed to delineate distinct patterns of post-term growth and to determine their association with the cognitive development of preterm children. Data from a prospective population-based cohort of 3,850 surviving infants born at less than 35 weeks of gestational age were used. Growth was assessed as the Body Mass Index (BMI) Z-scores at 3, 9, 18, 24, 36, 48, and 60 months...
2017: PloS One
https://www.readbyqxmd.com/read/28350830/first-year-physical-activity-findings-from-turn-up-the-heat-healthy-eating-and-activity-time-in-summer-day-camps
#7
R Glenn Weaver, Keith Brazendale, Jessica L Chandler, Gabrielle M Turner-McGrievy, Justin B Moore, Jennifer L Huberty, Dianne S Ward, Michael W Beets
BACKGROUND: Summer day camps (SDCs) serve 14 million children yearly in the U.S. and aim to provide participating children with 60 minutes of moderate-to-vigorous physical activity (MVPA). This study evaluated an intervention designed to increase the percent of children meeting this MVPA guideline. DESIGN: Two-group, pre-post quasi-experimental. SETTING/PARTICIPANTS: Twenty SDCs serving 1,830 children aged 5-12 years were assigned to MVPA intervention (n = 10) or healthy eating attention control (n = 10)...
2017: PloS One
https://www.readbyqxmd.com/read/28350827/time-spent-by-belgian-hospital-pharmacists-on-supply-disruptions-and-drug-shortages-an-exploratory-study
#8
Elfi De Weerdt, Thomas De Rijdt, Steven Simoens, Minne Casteels, Isabelle Huys
INTRODUCTION: Supply problems of drugs are an increasing and worldwide problem, also in Belgium. Hospital pharmacists try to manage drug supply problems to minimize the impact on patient care. This study aims to quantify in a detailed manner how much time employees of 17 Belgian hospital pharmacies spend on drug supply problems. METHODS: During six months, employees of Belgian hospital pharmacies filled in the daily time spent on drug supply problems using a template containing all steps which can be executed to manage drug supply problems...
2017: PloS One
https://www.readbyqxmd.com/read/28350821/neuropathological-diagnoses-and-clinical-correlates-in-older-adults-in-brazil-a-cross-sectional-study
#9
Claudia K Suemoto, Renata E L Ferretti-Rebustini, Roberta D Rodriguez, Renata E P Leite, Luciana Soterio, Sonia M D Brucki, Raphael R Spera, Tarcila M Cippiciani, Jose M Farfel, Alexandre Chiavegatto Filho, Michel Satya Naslavsky, Mayana Zatz, Carlos A Pasqualucci, Wilson Jacob-Filho, Ricardo Nitrini, Lea T Grinberg
BACKGROUND: Clinicopathological studies are important in determining the brain lesions underlying dementia. Although almost 60% of individuals with dementia live in developing countries, few clinicopathological studies focus on these individuals. We investigated the frequency of neurodegenerative and vascular-related neuropathological lesions in 1,092 Brazilian admixed older adults, their correlation with cognitive and neuropsychiatric symptoms, and the accuracy of dementia subtype diagnosis...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28350644/disassociating-lung-mechanics-and-oxygenation-in-pediatric-acute-respiratory-distress-syndrome
#10
Nadir Yehya, Neal J Thomas
OBJECTIVES: Both oxygenation and peak inspiratory pressure are associated with mortality in pediatric acute respiratory distress syndrome. Since oxygenation and respiratory mechanics are linked, it is difficult to identify which variables, pressure or oxygenation, are independently associated with outcome. We aimed to determine whether respiratory mechanics (peak inspiratory pressure, positive end-expiratory pressure, ΔP [PIP minus PEEP], tidal volume, dynamic compliance [Cdyn]) or oxygenation (PaO2/FIO2) was associated with mortality...
March 27, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28350621/visit-to-visit-sbp-variability-and-cardiovascular-disease-in-a-multiethnic-primary-care-setting-10-year-retrospective-cohort-study
#11
Yook Chin Chia, Siew Mooi Ching, Hooi Min Lim
OBJECTIVES: The current study aims to determine the relationship of long-term visit-to-visit variability of SBP to cardiovascular disease (CVD) in a multiethnic primary care setting. METHOD: This is a retrospective study of a cohort of 807 hypertensive patients over a period of 10 years. Three-monthly clinic blood pressure readings were used to derive blood pressure variability (BPV), and CVD events were captured from patient records. RESULTS: Mean age at baseline was 57...
May 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28350560/outcomes-related-to-the-use-of-frozen-plasma-or-pooled-solvent-detergent-treated-plasma-in-critically-ill-children
#12
Maraya N Camazine, Oliver Karam, Ryan Colvin, Stephane Leteurtre, Pierre Demaret, Marisa Tucci, Jennifer A Muszynski, Simon Stanworth, Philip C Spinella
OBJECTIVE: To determine if the use of fresh frozen plasma/frozen plasma 24 hours compared to solvent detergent plasma is associated with international normalized ratio reduction or ICU mortality in critically ill children. DESIGN: This is an a priori secondary analysis of a prospective, observational study. Study groups were defined as those transfused with either fresh frozen plasma/frozen plasma 24 hours or solvent detergent plasma. Outcomes were international normalized ratio reduction and ICU mortality...
March 27, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28350545/reliability-of-dose-volume-constraint-inference-from-clinical-data
#13
C M Lutz, D S Møller, L Hoffmann, M M Knap, M Alber
Dose volume histogram points (DVHPs) frequently serve as dose constraints in radiotherapy treatment planning. An experiment was designed to investigate the reliability of DVHP inference from clinical data for multiple cohort sizes and complication incidence rates. The experimental background was radiation pneumonitis in non-small cell lung cancer and the DVHP inference method was based on logistic regression. From 102 NSCLC real-life dose distributions and a postulated DVHP model, an 'ideal' cohort was generated where the most predictive model was equal to the postulated model...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28346907/long-term-associations-of-modeled-and-self-reported-measures-of-exposure-to-air-pollution-and-noise-at-residence-on-prevalent-hypertension-and-blood-pressure
#14
Anitha Pitchika, Regina Hampel, Kathrin Wolf, Ute Kraus, Josef Cyrys, Wolfgang Babisch, Annette Peters, Alexandra Schneider
Air pollution, traffic noise and noise annoyance are suggested to be associated with hypertension and blood pressure (BP); however, the evidence remains inconsistent. Our study examined the long-term associations of modeled and self-reported measures of air pollution and traffic noise on prevalent hypertension and BP. We analyzed cross-sectional data from 2552 participants aged 31-72years from the KORA F4 (2006-2008) study conducted in the region of Augsburg, Germany. Land-use regression models were used to estimate residential long-term exposure to particulate matter <2...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346670/neospora-caninum-in-beef-herds-in-new-south-wales-australia-2-analysis-of-risk-factors
#15
B J Moloney, C Heuer, P D Kirkland
OBJECTIVE: To determine the influence of farm-level and animal-level factors on the seroprevalence of antibodies to Neospora caninum and associations between seropositivity and reproductive outcomes. METHODS: A questionnaire for a cross-sectional survey was posted to the 63 properties with a herd size ≥50 beef breeding cows that had participated in a previous seroprevalence study. Correspondence analysis, which does not appear to have been used previously in any Australian studies of livestock diseases, was used in conjunction with logistic regression to analyse the data...
April 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28346620/varied-rates-of-implementation-of-patient-centered-medical-home-features-and-residents-perceptions-of-their-importance-based-on-practice-experience
#16
M Patrice Eiff, Larry A Green, Geoff Jones, Alex Verdieck Devlaeminck, Elaine Waller, Eve Dexter, Miguel Marino, Patricia A Carney
BACKGROUND AND OBJECTIVES: Little is known about how the patient-centered medical home (PCMH) is being implemented in residency practices. We describe both the trends in implementation of PCMH features and the influence that working with PCMH features has on resident attitudes toward their importance in 14 family medicine residencies associated with the P4 Project. METHODS: We assessed 24 residency continuity clinics annually between 2007-2011 on presence or absence of PCMH features...
March 2017: Family Medicine
https://www.readbyqxmd.com/read/28346589/comparison-of-antibiotic-therapy-and-appendectomy-for-acute-uncomplicated-appendicitis-in-children-a-meta-analysis
#17
Libin Huang, Yuan Yin, Lie Yang, Cun Wang, Yuan Li, Zongguang Zhou
Importance: Antibiotic therapy for acute uncomplicated appendicitis is effective in adult patients, but its application in pediatric patients remains controversial. Objective: To compare the safety and efficacy of antibiotic treatment vs appendectomy as the primary therapy for acute uncomplicated appendicitis in pediatric patients. Data Sources: The PubMed, MEDLINE, EMBASE, and Cochrane Library databases and the Cochrane Controlled Trials Register for randomized clinical trials were searched through April 17, 2016...
March 27, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28346566/gene-gene-interaction-between-pparg-and-apoe-gene-on-late-onset-alzheimer-s-disease-a-case-control-study-in-chinese-han-population
#18
S Wang, L Guan, D Luo, J Liu, H Lin, X Li, X Liu
AIMS: The aim was to investigate the impact of PPARG and APOE gene single nucleotide polymorphisms (SNPs) and additional gene- gene interaction on late-onset Alzheimer's disease (LOAD) risk based on Chinese Han population. METHODS: A total of 928 participants (466 males, 462 females), with a mean age of 81.3 ± 16.4 years old, were included in the study, including 460 LOAD patients and 468 normal controls participants. Logistic regression was performed to investigate association between SNP and LOAD risk and generalized multifactor dimensionality reduction (GMDR) was used to analysis the gene-gene interaction...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346536/water-sanitation-and-hygiene-wash-and-environmental-risk-factors-for-soil-transmitted-helminth-intensity-of-infection-in-timor-leste-using-real-time-pcr
#19
Suzy J Campbell, Susana V Nery, Rebecca Wardell, Catherine A D'Este, Darren J Gray, James S McCarthy, Rebecca J Traub, Ross M Andrews, Stacey Llewellyn, Andrew J Vallely, Gail M Williams, Archie C A Clements
BACKGROUND: No investigations have been undertaken of risk factors for intensity of soil-transmitted helminth (STH) infection in Timor-Leste. This study provides the first analysis of risk factors for intensity of STH infection, as determined by quantitative PCR (qPCR), examining a broad range of water, sanitation and hygiene (WASH) and environmental factors, among communities in Manufahi District, Timor-Leste. METHODS: A baseline cross-sectional survey of 18 communities was undertaken as part of a cluster randomised controlled trial, with additional identically-collected data from six other communities...
March 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28346472/can-group-based-reassuring-information-alter-low-back-pain-behavior-a-cluster-randomized-controlled-trial
#20
Pernille Frederiksen, Aage Indahl, Lars L Andersen, Kim Burton, Rasmus Hertzum-Larsen, Tom Bendix
BACKGROUND: Low back pain (LBP) is common in the population and multifactorial in nature, often involving negative consequences. Reassuring information to improve coping is recommended for reducing the negative consequences of LBP. Adding a simple non-threatening explanation for the pain (temporary muscular dysfunction) has been successful at altering beliefs and behavior when delivered with other intervention elements. This study investigates the isolated effect of this specific information on future occupational behavior outcomes when delivered to the workforce...
2017: PloS One
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