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https://www.readbyqxmd.com/read/28633264/rapidly-progressive-bioprosthetic-aortic-valve-stenosis-due-to-bartonella-species-endocarditis
#1
Kathy Schnitzer, Zafrir Or, Shtiwi Sawaed, Erez Sharoni, Naiel Bisharat
Rapid progression of valvular stenosis in the setting of infective endocarditis is extremely rare. Here we describe a patient with Bartonella endocarditis on a bioprosthetic aortic valve that caused rapidly progressive aortic stenosis without regurgitation. At operation the bioprosthetic valve was severely fibrotic and calcified, with markedly thickened and distorted leaflets and circular partial detachment from the aortic ring. The patient underwent aortic root replacement with aortic bioprosthesis and aortic grafting with reimplantation of the coronary ostia...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28628613/immunosuppressive-and-angiogenic-cytokine-profile-associated-with-bartonella-bacilliformis-infection-in-post-outbreak-and-endemic-areas-of-carrion-s-disease-in-peru
#2
Maria J Pons, Cláudia Gomes, Ruth Aguilar, Diana Barrios, Miguel Angel Aguilar-Luis, Joaquim Ruiz, Carlota Dobaño, Juana Del Valle-Mendoza, Gemma Moncunill
Analysis of immune responses in Bartonella bacilliformis carriers are needed to understand acquisition of immunity to Carrion's disease and may allow identifying biomarkers associated with bacterial infection and disease phases. Serum samples from 144 healthy subjects from 5 villages in the North of Peru collected in 2014 were analyzed. Four villages had a Carrion's disease outbreak in 2013, and the other is a traditionally endemic area. Thirty cytokines, chemokines and growth factors were determined in sera by fluorescent bead-based quantitative suspension array technology, and analyzed in relation to available data on bacteremia quantified by RT-PCR, and IgM and IgG levels measured by ELISA against B...
June 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28624614/gene-transfer-agent-promotes-evolvability-within-the-fittest-subpopulation-of-a-bacterial-pathogen
#3
Maxime Québatte, Matthias Christen, Alexander Harms, Jonas Körner, Beat Christen, Christoph Dehio
The Bartonella gene transfer agent (BaGTA) is an archetypical example for domestication of a phage-derived element to permit high-frequency genetic exchange in bacterial populations. Here we used multiplexed transposon sequencing (TnSeq) and single-cell reporters to globally define the core components and transfer dynamics of BaGTA. Our systems-level analysis has identified inner- and outer-circle components of the BaGTA system, including 55 regulatory components, as well as an additional 74 and 107 components mediating donor transfer and recipient uptake functions...
June 14, 2017: Cell Systems
https://www.readbyqxmd.com/read/28619142/drivers-of-bartonella-infection-in-micromammals-and-their-fleas-in-a-mediterranean-peri-urban-area
#4
Aitor Cevidanes, Laura Altet, Andrea D Chirife, Tatiana Proboste, Javier Millán
People living at the human/wildlife interface are at risk of becoming infected with Bartonella for which micromammals act as reservoir. We aimed to determine the factors related to the prevalence of Bartonella and its haplotype diversity in micromammals and in their fleas in a Mediterranean peri-urban environment. We analyzed 511 micromammals, chiefly 407 wood mice (Apodemus sylvaticus), captured into Barcelona metropolitan area (Spain) in spring and autumn from 2011 to 2013 in two natural and two adjacent residential areas, their fleas (grouped in 218 monospecific pools) and 29 fetuses from six Bartonella-positive female wood mice...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28588842/neurological-and-immunological-dysfunction-in-two-patients-with-bartonella-henselae-bacteremia
#5
David L Kaufman, Andreas M Kogelnik, Robert B Mozayeni, Natalie A Cherry, Edward B Breitschwerdt
Recently, BAPGM enrichment culture has documented Bartonella bacteremia in previously healthy, "nonimmunocompromised" patients following arthropod exposures. Neurobartonellosis should be among the differential diagnoses for patients with persistent or recurrent neurological symptoms of undetermined etiology. Microbiological and immunological testing should be concurrently pursued to determine whether defective immune function accompanies Bartonella bacteremia.
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28558145/prevalence-of-vector-borne-pathogens-in-southern-california-dogs-with-clinical-and-laboratory-abnormalities-consistent-with-immune-mediated-disease
#6
L Kidd, B Qurollo, M Lappin, K Richter, J R Hart, S Hill, C Osmond, E B Breitschwerdt
BACKGROUND: Studies investigating the prevalence of vector-borne pathogens in southern California dogs are limited. Occult infections might be misdiagnosed as idiopathic immune-mediated disease. HYPOTHESIS/OBJECTIVES: (1) To determine the prevalence of vector-borne pathogens in southern California dogs with compatible clinical findings using PCR and serologic panels and (2) to determine whether testing convalescent samples and repeating PCR on acute samples using the same and different gene targets enhance detection...
May 30, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28541836/description-of-candidatus-bartonella-fadhilae-n-sp-and-candidatus-bartonella-sanaae-n-sp-bartonellaceae-from-dipodillus-dasyurus-and-sekeetamys-calurus-gerbillinae-from-the-sinai-massif-egypt
#7
Mohammed Alsarraf, Eman M E Mohallal, Ewa J Mierzejewska, Jolanta Behnke-Borowczyk, Renata Welc-Falęciak, Małgorzata Bednarska, Lukasz Dziewit, Samy Zalat, Francis Gilbert, Jerzy M Behnke, Anna Bajer
Bartonella spp. are parasites of mammalian erythrocytes and endothelial cells, transmitted by blood-feeding arthropod ectoparasites. Different species of rodents may constitute the main hosts of Bartonella, including several zoonotic species of Bartonella. The aim of this study was to identify and compare Bartonella species and genotypes isolated from rodent hosts from the South Sinai, Egypt. Prevalence of Bartonella infection was assessed in rodents (837 Acomys dimidiatus, 73 Acomys russatus, 111 Dipodillus dasyurus, and 65 Sekeetamys calurus) trapped in 2000, 2004, 2008, and 2012 in four dry montane wadis around St...
May 25, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28539197/candidatus-neoehrlichia-mikurensis-and-borrelia-burgdorferi-sensu-lato-detected-in-the-blood-of-norwegian-patients-with-erythema-migrans
#8
H Quarsten, A Grankvist, L Høyvoll, I B Myre, T Skarpaas, V Kjelland, C Wenneras, S Noraas
The most common tick-borne human disease in Norway is Lyme borreliosis. Ticks in Norway also harbour less known disease-causing agents such as Candidatus Neoehrlichia mikurensis, Borrelia miyamotoi and Rickettsia helvetica. However, human infections caused by these pathogens have never been described in Norway. The main aims of the study were to evaluate the contribution of several tick-borne bacterial agents, other than Borrelia burgdorferi sensu lato, to zoonotic diseases in Norway and to determine their clinical pictures...
May 13, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28534089/comparison-of-microbiomes-between-red-poultry-mite-populations-dermanyssus-gallinae-predominance-of-bartonella-like-bacteria
#9
Jan Hubert, Tomas Erban, Jan Kopecky, Bruno Sopko, Marta Nesvorna, Martina Lichovnikova, Sabine Schicht, Christina Strube, Olivier Sparagano
Blood feeding red poultry mites (RPM) serve as vectors of pathogenic bacteria and viruses among vertebrate hosts including wild birds, poultry hens, mammals, and humans. The microbiome of RPM has not yet been studied by high-throughput sequencing. RPM eggs, larvae, and engorged adult/nymph samples obtained in four poultry houses in Czechia were used for microbiome analyses by Illumina amplicon sequencing of the 16S ribosomal RNA (rRNA) gene V4 region. A laboratory RPM population was used as positive control for transcriptome analysis by pyrosequencing with identification of sequences originating from bacteria...
May 22, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28526098/first-description-of-bartonella-koehlerae-infection-in-a-spanish-dog-with-infective-endocarditis
#10
María-Dolores Tabar, Laura Altet, Ricardo G Maggi, Jaume Altimira, Xavier Roura
BACKGROUND: Bartonella koehlerae has been recently described as a new cat- and cat fleas-associated agent of culture-negative human endocarditis. It has been also encountered in one dog from Israel and six dogs from the USA, but other clinically relevant reports involving this bacterium are lacking. RESULTS: A 7-year-old intact male mixed dog presented with clinico-pathological signs consistent with mitral endocarditis and cutaneous hemangiosarcoma. Molecular studies revealed the presence of Bartonella koehlerae DNA in samples from blood and mitral valve tissue...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28504633/-tick-borne-infections-in-denmark
#11
Bo Bødker Jensen, Lukas Frans Ocias, Nanna Skaarup Andersen, Ram Benny Dessau, Karen Angeliki Krogfelt, Sigurdur Skarphedinsson
The castor bean tick, Ixodes ricinus, is common in woodlands in most of Denmark. Besides Borrelia burgdorferi, it can harbour a number of pathogenic microorganisms such as tick-borne encephalitis virus, Anaplasma phagocytophilum, Rickettsia helvetica, Francisella tularensis, Candidatus Neoehrlichia mikurensis, Bartonella spp., Borrelia miyamotoi and Babesia spp. These tick-borne infections should be a differential diagnostic consideration during the tick season in Denmark. We review the distribution, clinical manifestations, diagnosis and treatment of these microorganisms...
May 15, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28502279/evidence-and-molecular-characterization-of-bartonella-spp-and-hemoplasmas-in-neotropical-bats-in-brazil
#12
P Ikeda, M C Seki, A O T Carrasco, L V Rudiak, J M D Miranda, S M M Gonçalves, E G L Hoppe, A C A Albuquerque, M M G Teixeira, C E Passos, K Werther, R Z Machado, M R André
The order Chiroptera is considered the second largest group of mammals in the world, hosting important zoonotic virus and bacteria. Bartonella and hemotropic mycoplasmas are bacteria that parasite different mammals' species, including humans, causing different clinical manifestations. The present work aimed investigating the occurrence and assessing the phylogenetic positioning of Bartonella spp. and Mycoplasma spp. in neotropical bats sampled from Brazil. Between December 2015 and April 2016, 325 blood and/or tissues samples were collected from 162 bats comprising 19 different species sampled in five states of Brazil...
May 15, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28490714/the-seroprevalence-of-bartonella-henselae-in-healthy-adults-in-korea
#13
Hea Yoon Kwon, Jae Hyoung Im, Sun Myoung Lee, Ji Hyeon Baek, Areum Durey, Shin-Goo Park, Jae-Seung Kang, Jin-Soo Lee
BACKGROUND/AIMS: Cat-scratch disease (CSD), caused by Bartonella henselae is one of the most common zoonosis. However, only several cases of B. henselae infection have been reported in Korea. This study investigated the seroprevalence of B. henselae in healthy adults and related risk factors. METHODS: Serum samples from 300 healthy participants were analyzed using an immunoglobulin G immunof luorescence assay (IFA) for B. henselae isolated in Korea. Surveys on the risk factors for B...
May 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28490579/bartonella-species-an-emerging-cause-of-blood-culture-negative-endocarditis
#14
REVIEW
Udoka Okaro, Anteneh Addisu, Beata Casanas, Burt Anderson
Since the reclassification of the genus Bartonella in 1993, the number of species has grown from 1 to 45 currently designated members. Likewise, the association of different Bartonella species with human disease continues to grow, as does the range of clinical presentations associated with these bacteria. Among these, blood-culture-negative endocarditis stands out as a common, often undiagnosed, clinical presentation of infection with several different Bartonella species. The limitations of laboratory tests resulting in this underdiagnosis of Bartonella endocarditis are discussed...
July 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28446372/prosthetic-valve-endocarditis-caused-by-bartonella-henselae-presenting-as-recurrent-fever-and-imitating-granulomatosis-with-polyangiitis
#15
Ryuichi Sada, Shunsuke Uno, Naoto Hosokawa, Tomoyoshi Komiya
No abstract text is available yet for this article.
April 23, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28418306/management-of-bartonella-prosthetic-valve-endocarditis-without-cardiac-surgery
#16
Padmasayee Papineni, Aisling Carroll, Johannes Radvan, Carolyn Hemsley, John Chambers, Nicholas Cortes, Timothy Harrison, John L Klein
Two cases of Bartonella prosthetic valve endocarditis were cured when treated for 2 weeks with gentamicin and 3 months with doxycycline. Clinical cure correlated with decreased Bartonella antibody titers. This report suggests a strategy to monitor, treat, and cure Bartonella prosthetic valve endocarditis.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28412525/liver-microbiome-of-peromyscus-leucopus-a-key-reservoir-host-species-for-emerging-infectious-diseases-in-north-america
#17
A André, A Mouton, V Millien, J Michaux
Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiome using next generation sequencing as a tool to detect potentially pathogenic strains. We used Peromyscus leucopus, the main reservoir host species of Lyme disease in eastern North America, as a model and sequenced V5-V6 regions of the 16S gene from 18 populations in southern Quebec (Canada). The Lactobacillus genus was found to dominate the liver microbiome...
April 13, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28411218/the-conjugative-relaxase-trwc-promotes-integration-of-foreign-dna-in-the-human-genome
#18
Coral González-Prieto, Richard Gabriel, Christoph Dehio, Manfred Schmidt, Matxalen Llosa
Bacterial conjugation is a mechanism of horizontal DNA transfer. The relaxase TrwC of the conjugative plasmid R388 cleaves one strand of the transferred DNA at the oriT, covalently attaches to it and leads the ssDNA into the recipient cell. In addition, TrwC catalyzes site-specific integration of the transferred DNA into its target sequence present in the genome of the recipient bacterium. Here, we report the analysis of the efficiency and specificity of the integrase activity of TrwC in human cells, using the Type IV Secretion System of the human pathogen Bartonella henselae to introduce relaxase-DNA complexes...
April 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28405890/seroprevalence-of-bartonella-species-in-patients-with-ocular-inflammation
#19
Joanna Brydak-Godowska, Dorota Kopacz, Piotr K Borkowski, Beata Fiecek, Agata Hevelke, Daniel Rabczenko, Stanisława Tylewska-Wierzbanowska, Dariusz Kęcik, Tomasz Chmielewski
Bartonella species, vector-borne etiologic agents of many systemic or self-limited infections, are responsible for a widening spectrum of diseases in humans, including inflammatory conditions of the eye. The aim of this study was to determine whether there is any relationship between uveitis and the evidence of Bartonella spp. infection in the serum, ocular fluid, and cataract mass in patients with intraocular inflammation. Polymerase chain reaction (PCR)-based tests and DNA sequencing were performed on surgery-extracted specimens of intraocular fluid and lens mass of 33 patients...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28404679/evaluation-of-taqman-array-card-tac-for-the-detection-of-central-nervous-system-infections-in-kenya
#20
Clayton O Onyango, Vladimir Loparev, Shirley Lidechi, Vinod Bhullar, D Scott Schmid, Kay Radford, Michael K Lo, Paul Rota, Barbara W Johnson, Jorge Munoz, Martina Oneko, Deron Burton, Carolyn M Black, John Neatherlin, Joel M Montgomery, Barry Fields
Infections of the central nervous system (CNS) are often acute with significant morbidity and mortality. Routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-Saharan Africa. We developed a TaqMan Array Card (TAC) that detects multiple pathogens simultaneously from cerebrospinal fluid (CSF). The 21-pathogen TAC assays include two parasites (Balamuthia mandrillaris and Acanthamoeba), six bacterial pathogens (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, and Bartonella) and 13 viruses (parechovirus, dengue, nipah, varicella zoster, mumps, measles, lyssa, herpes simplex virus 1 and 2, Epstein Barr virus, enterovirus, cytomegalovirus and chikungunya)...
April 12, 2017: Journal of Clinical Microbiology
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