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https://www.readbyqxmd.com/read/28654855/clinical-profile-and-neurodevelopmental-outcome-of-new-onset-acute-symptomatic-seizures-in-children
#1
Vimlesh Soni, Pratibha Singhi, Arushi Gahlot Saini, Prabhjot Malhi, Radha K Ratho, Baijayantimala Mishra, Sunit C Singhi
PURPOSE: To study clinical profile, neurodevelopmental outcome and its predictors in children with acute symptomatic seizures (ASS). METHODS: Short-term neurodevelopmental outcome and predictors of poor outcomes were prospectively assessed in 105 consecutive children with ASS aged 3 months-12 years RESULTS: Mean age was 51.2+42.2months (3-144 months); 67.2% were males. Central nervous system (CNS) infection in 82%, status epilepticus in 15.2%, abnormal neuroimaging in 62...
June 17, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28654830/analysis-of-variations-of-correlation-dimension-and-nonlinear-interdependence-for-the-prediction-of-pediatric-myoclonic-seizures-a-preliminary-study
#2
Mohamad Amin Sharifi Kolarijani, Susan Amirsalari, Mohsen Reza Haidari
In this preliminary study, we evaluated the predictive ability of Correlation Dimension (CD) and Nonlinear Interdependence (NI) for seizures in pediatric myoclonic epilepsy patients. Scalp EEG recordings of eight diagnosed cases of myoclonic epilepsy were analyzed using Receiver Operating Curve (ROC) for discriminating the preictal period from interictal period. Furthermore, based on clinical seizure characteristics and EEG data, the spatiotemporal patterns of measures in clinically relevant areas of the brain were compared with other areas for each patient...
June 17, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28654799/neurobehavioral-consequences-of-continuous-spike-and-waves-during-slow-sleep-csws-in-a-pediatric-population-a-pattern-of-developmental-hindrance
#3
Valentina De Giorgis, Melissa Filippini, Joyce Ann Macasaet, Silvia Masnada, Pierangelo Veggiotti
INTRODUCTION: Continuous spike and waves during slow sleep (CSWS) is a typical EEG pattern defined as diffuse, bilateral and recently also unilateral or focal localization spike-wave occurring in slow sleep or non-rapid eye movement sleep. Literature results so far point out a progressive deterioration and decline of intellectual functioning in CSWS patients, i.e. a loss of previously normally acquired skills, as well as persistent neurobehavioral disorders, beyond seizure and EEG control...
June 24, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28654561/influenza-associated-encephalitis-encephalopathy-identified-by-the-australian-childhood-encephalitis-study-2013-2015
#4
Philip N Britton, Russell C Dale, Christopher C Blyth, Kristine Macartney, Nigel Crawford, Helen Marshall, Julia Clark, Elizabeth Elliott, Richard I Webster, Allen C Cheng, Robert Booy, Cheryl A Jones
BACKGROUND: Influenza associated encephalitis/encephalopathy (IAE) is an important cause of acute encephalitis syndrome in children. IAE includes a series of clinico-radiologic syndromes or acute encephalopathy syndromes that have been infrequently reported outside East Asia. We aimed to describe case of IAE identified by the Australian Childhood Encephalitis study. METHODS: Children ≤14 years of age with suspected encephalitis were prospectively identified in 5 hospitals in Australia...
June 24, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28653967/exercise-associated-hyponatremia-in-a-lactating-female
#5
Zach Bailowitz, Raymond Grams, David Teeple, Tamara Hew-Butler
A 37-year-old woman presented to the emergency department with severe headache, which quickly progressed to altered mental status and seizure activity in hospital. Her initial serum sodium concentration ([Na]) was 126 mmol/L. In the 24 hours before admission, she exercised vigorously for 120 minutes (interval training plus yoga) and also consumed more than 4 liters of fluid during that time to both stay hydrated and facilitate milk production because she was actively nursing 2 children. Her serum [Na] and altered mental status corrected slowly over the next 48 hours with furosemide, hypertonic saline, and fluid restriction...
July 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28653518/-infants-poisoned-with-cannabis
#6
S Redant, N Genis, A Thiery, E Rebuffat, D Biarent
We reported three cases of infants poisoned with cannabis. These patients presented with acute neurological disorders such as drowsiness accompanied by hypotonia, mydriasis and seizure. Cannabis was found in all children either in the urine or in the blood. These cases illustrated that young age should not exclude toxicologic analysis in acute neurological disorders. Cannabis poisoning in infants is a rare reason for consultation. Clinical signs and symptoms are unspecific and severe manifesta- tions in pediatric age are not well known by emergency physicians and paediatricians...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28653352/individualised-dosing-algorithms-and-therapeutic-monitoring-for-antiepileptic-drugs
#7
Sven C van Dijkman, Sebastian G Wicha, Meindert Danhof, Oscar E Della Pasqua
Pharmacokinetic (PK) models exist for most antiepileptic drugs (AEDs). Yet, their use in clinical practice to assess inter-individual differences and derive individualised doses has been limited. Here we show how model-based dosing algorithms can be used to ensure attainment of target exposure and improve treatment response in patients. Using simulations, different treatment scenarios were explored for 11 commonly used AEDs. For each drug, five scenarios were considered: i. all patients receive the same dose...
June 27, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28653281/fingolimod-exerts-only-temporary-antiepileptogenic-effects-but-longer-lasting-positive-effects-on-behavior-in-the-wag-rij-rat-absence-epilepsy-model
#8
Antonio Leo, Rita Citraro, Nicola Amodio, Caterina De Sarro, Maria Eugenia Gallo Cantafio, Andrew Constanti, Giovambattista De Sarro, Emilio Russo
One of the major challenges in the epilepsy field is identifying disease-modifying drugs in order to prevent or delay spontaneous recurrent seizure onset or to cure already established epilepsy. It has been recently reported that fingolimod, currently approved for the treatment of relapsing-remitting multiple sclerosis, has demonstrated antiepileptogenic effects in 2 different preclinical models of acquired epilepsy. However, to date, no data exist regarding the role of fingolimod against genetic epilepsy. Therefore, we have addressed this issue by studying the effects of fingolimod in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats, a well-established genetic model of absence epilepsy, epileptogenesis, and neuropsychiatric comorbidity...
June 26, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28653247/post-traumatic-headache-in-patients-with-minimal-traumatic-intracranial-hemorrhage-after-traumatic-brain-injury-a-retrospective-matched-case-control-study
#9
Chang-Ki Hong, Yu Shik Shim, Sook Young Sim, Jin-Yang Joo, Min A Kwon, Yong Bae Kim, Joonho Chung
BACKGROUND: No evidence is available on the risks of neurologically asymptomatic minimal traumatic intracranial hemorrhage (mTIH) in patients with traumatic brain injury (TBI) for post-traumatic headache (PTH). The purpose of this study was to investigate whether mTIH in patients with TBI was associated with PTH and to evaluate its risk factors. METHODS: Between September 2009 and December 2014, 1484 patients with TBI were treated at our institution, 57 of whom had mTIH after TBI and were include in this study...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28653176/amino-acid-synthesis-deficiencies
#10
REVIEW
T J de Koning
In recent years the number of disorders known to affect amino acid synthesis has grown rapidly. Nor is it just the number of disorders that has increased: the associated clinical phenotypes have also expanded spectacularly, primarily due to the advances of next generation sequencing diagnostics. In contrast to the "classical" inborn errors of metabolism in catabolic pathways, in which elevated levels of metabolites are easily detected in body fluids, synthesis defects present with low values of metabolites or, confusingly, even completely normal levels of amino acids...
June 26, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28652973/influenza-associated-seizures-in-healthy-adults-report-of-3-cases
#11
Aintziñe Ruisanchez-Nieva, Amaia Martinez-Arroyo, Marian Gomez-Beldarrain, Jone Bocos Portillo, Juan Carlos Garcia-Monco
To describe seizures occurring in 3 healthy adults with influenza infection. Seizures associated to influenza infection are rare in adults without encephalitis. Clinical observations of 3 healthy adult patients with influenza A and B infection and seizures. We present here 3 healthy adult patients with seizures related to influenza A or B infection without evidence encephalitis, encephalopathy or any other cause for seizures. Prognosis was excellent. Seizures can occur in healthy adults with influenza infection without evidence of encephalitis, a possibility to be borne in mind to avoid potentially harmful therapeutic and diagnostic procedures...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28652950/highlights-on-cerebral-arteriovenous-malformation-treatment-using-combined-embolization-and-stereotactic-radiosurgery-why-outcomes-are-controversial
#12
REVIEW
Faustina N A Sackey, Nathaneal R Pinsker, Benjamin N Baako
Cerebral arteriovenous malformations (AVMs) are abnormal tangling between brain arteries and veins causing an arteriovenous shunt called nidus with an intervening network of vessels from the region of formation and spans through the brain. AVM effect is debilitating to the affected individual due to associated persistent intracerebral hemorrhage, resulting in significant occurrences of seizures and neurological damage. Recent innovative treatments involve a combination of embolization (Embo) procedures followed by stereotactic radiosurgery (SRS), designed to optimize less-invasive practice for the obliteration of the AVMs...
May 22, 2017: Curēus
https://www.readbyqxmd.com/read/28652948/streptococcus-mutans-a-potential-risk-factor-in-recurrent-hemorrhagic-stroke
#13
Tarek R Mansour, Yasaman Alam, Layth Dahbour, Ahmed Alnemari, Mouhammad Jumaa, Jason L Schroeder
Stroke is the fifth leading cause of death and is responsible for approximately nine percent of all deaths worldwide. Cases of Streptococcus mutans (S. mutans)-induced intracerebral hemorrhage as a result of bloodstream infections have seldom been reported. New reports show that bacteria with specific collagen binding proteins (CBPs), such as the Cnm type produced by S. mutans, may inhibit platelet aggregation and cause bleeding. In this article, we report on a 62-year-old man with a recent history of left frontal intracerebral hemorrhage (ICH) who presented to the emergency department after a fall due to suspected seizure while in rehabilitation...
May 19, 2017: Curēus
https://www.readbyqxmd.com/read/28652270/neurogenic-pulmonary-oedema-a-rare-cause-of-maternal-collapse
#14
Huma Farooq, Sukrutha Veerareddy, Eli Silber
Acute pulmonary oedema is a significant cause of morbidity and mortality in pregnant and postpartum women. We present an unusual case of near-fatal acute pulmonary oedema in a pregnant woman, which was attributed to the acute onset of neurogenic pulmonary oedema secondary to epileptic seizure activity. The patient required supportive management in the intensive care setting for a short period and subsequently made complete recovery with regular neurological follow-up arranged for the management of her epilepsy...
June 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28652224/focal-epilepsy-with-paroxysmal-pain-due-to-somatic-injury
#15
Tao Yu, Chang Liu, Guojun Zhang, Liang Qiao, Duanyu Ni, Yuping Wang, Yongjie Li
We present two cases with paroxysmal pain that developed after a somatic injury to the trunk. The main characteristic of the episodes was paroxysmal severe pain, mainly located in the original region of somatic injury, with ipsilateral tonic or dystonic behaviour. The clinical characteristics supported a diagnosis of focal epilepsy. Both scalp EEG and MEG findings suggested epileptic activities on the contralateral central cortex. The focal seizures had a good response to antiepileptic drugs. It is hypothesized that peripheral somatic injuries can modify cortical excitability and lead to plastic changes in the sensory/motor cortex, ultimately resulting in focal seizures...
June 24, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28651171/the-relevance-of-inter-and-intrastrain-differences-in-mice-and-rats-and-their-implications-for-models-of-seizures-and-epilepsy
#16
REVIEW
Wolfgang Löscher, Russell J Ferland, Thomas N Ferraro
It is becoming increasingly clear that the genetic background of mice and rats, even in inbred strains, can have a profound influence on measures of seizure susceptibility and epilepsy. These differences can be capitalized upon through genetic mapping studies to reveal genes important for seizures and epilepsy. However, strain background and particularly mixed genetic backgrounds of transgenic animals need careful consideration in both the selection of strains and in the interpretation of results and conclusions...
June 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28651170/an-analysis-of-quality-of-life-qol-in-patients-with-epilepsy-and-comorbid-psychogenic-nonepileptic-seizures-pnes-after-vagus-nerve-stimulation-vns
#17
Andrew C Vivas, Christian J Reitano, Hena Waseem, Selim R Benbadis, Fernando L Vale
PURPOSE: Patients with epilepsy (PWE) may suffer from comorbid psychogenic nonepileptic seizures (PNES). The efficacy of vagus nerve stimulation (VNS) in the treatment of epilepsy and depression is established, however the impact on PNES is unknown. Since many patients with PNES have comorbid depression, we explored the impact on quality of life (QOL) that VNS has on PWE and PNES. METHODS: The video electroencephalogram (vEEG) of all patients who underwent VNS at our institution was reviewed...
June 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28651124/a-review-of-people-who-did-not-attend-an-epilepsy-clinic-and-their-clinical-outcomes
#18
I Minshall, A Neligan
PURPOSE: To review the clinical outcomes of people who failed to attend or failed subsequent follow up in a Primary Care based specialist epilepsy service. METHOD: The case notes of 200 people who had failed to initially attend the service or subsequent follow up from 2005 to 2013 were reviewed. RESULTS: Clinical outcomes were determined for 152 people, with the remaining 48 having left the area. For those not attending at all, 64% had no further recorded events, a further 22% came under alternative specialist care and were managed appropriately, 6% were already in remission at the time of referral or at follow up and stayed seizure free...
June 17, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28651123/seizures-enamel-defects-and-psychomotor-developmental-delay-the-first-patient-with-kohlsch%C3%A3-tter-t%C3%A3-nz-syndrome-caused-by-a-rogdi-gene-deletion
#19
Raphael Johannes Morscher, Christian Rauscher, Wolfgang Sperl, Olaf Rittinger
No abstract text is available yet for this article.
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28651086/age-at-first-febrile-seizure-correlates-with-perinatal-maternal-emotional-symptoms
#20
Fanny Thébault-Dagher, Catherine M Herba, Jean R Séguin, Gina Muckle, Sonia J Lupien, Lionel Carmant, Marie-Noëlle Simard, Gabriel D Shapiro, William D Fraser, Sarah Lippé
OBJECTIVE: Prenatal exposure to stress and fever are factors lowering seizure threshold in animal models. The fever effect on seizure threshold is well documented in human infants, however the associations between maternal perinatal stress and infants' susceptibility to seizures is unknown. This is the first study in humans to investigate longitudinally, whether in humans, the effect of maternal perinatal emotional symptoms such as stress, anxiety and depression that may trigger a biological stress response on age at first seizure occurrence...
June 10, 2017: Epilepsy Research
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