Nancy Tripathi, Aliva Naik, Dulla Naveen Kumar, Nivedita Bhardwaj, Bharat Goel, Sanjay Kumar, Sanheeta Chakrabarty, Amit Ranjan, Santosh Kumar Guru, Sanjeev Kumar, Ashish Agrawal, Shreyans K Jain
The compound 2,3-dehydrosilychristin, a flavonolignan linked to silychristin and silymarin, remains intriguing due to its challenging isolation from silymarin. While silymarin has been the exclusive source of flavonolignans - silybin, silychristin and silydianin - 2,3-dehydrosilychristin is reported in this study from Vitex negundo Linn. leaves. 2,3-Dehydrosilychristin ( 7 ) and 14 other compounds were isolated through focused extraction. Its subsequent pharmacological evaluation demonstrated potent antioxidant and in-vitro anti-inflammatory effects, notably inhibiting cytokines TNF-α, IL-6, IL-8 and VEGF...
February 9, 2024: Natural Product Research