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https://www.readbyqxmd.com/read/28497369/co-enzyme-q10-and-acetyl-salicylic-acid-enhance-hsp70-expression-in-primary-chicken-myocardial-cells-to-protect-the-cells-during-heat-stress
#1
Jiao Xu, Shu Tang, Bin Yin, Jiarui Sun, Erbao Song, Endong Bao
We investigated the effects of co-enzyme Q10 (Q10) and acetyl salicylic acid (ASA) on expression of Hsp70 in the protection of primary chicken myocardial cells during heat stress. Western blot analysis showed that Q10 and ASA accelerated the induction of Hsp70 when chicken myocardial cells were exposed to hyperthermia. In the absence of heat stress, however, neither Q10 nor ASA are able to upregulate Hsp70 expression. Analysis of enzymes that respond to cellular damage and pathological examination revealed that ectopic expression of ASA and Q10 alleviate cellular damage during heat stress...
May 11, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28424622/pravastatin-chronic-treatment-sensitizes-hypercholesterolemic-mice-muscle-to-mitochondrial-permeability-transition-protection-by-creatine-or-coenzyme-q10
#2
Estela N B Busanello, Ana C Marques, Noelia Lander, Diogo N de Oliveira, Rodrigo R Catharino, Helena C F Oliveira, Anibal E Vercesi
Statins are efficient cholesterol-lowering medicines utilized worldwide. However, 10% of patients suffer from adverse effects specially related to skeletal muscle function. Pro- or anti-oxidant effects of statins have been reported. Here we hypothesized that statins induce muscle mitochondrial oxidative stress leading to mitochondrial permeability transition (MPT) which may explain statin muscle toxicity. Thus, our aims were to investigate the effects of statin chronic treatment on muscle mitochondrial respiration rates, MPT and redox state indicators in the context of hypercholesterolemia...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28422588/alterations-in-redox-homeostasis-during-recovery-from-unexplained-underperformance-syndrome-in-an-elite-international-rower
#3
Nathan A Lewis, Ann Redgrave, Mark Homer, Richard Burden, Wendy Martinson, Brian Moore, Charles R Pedlar
PURPOSE: This case study of an international rower examines a diagnosis of Unexplained Under Performance Syndrome (UUPS or Overtraining Syndrome) describing a full recovery and return to elite competition the same year. METHODS: On diagnosis and 4 and 14 months post-diagnosis, detailed assessments including physiological, nutritional, and biomarkers were made. RESULTS: Clinical examination and laboratory results for haematology, biochemistry, thyroid function, immunology, vitamins and minerals were unremarkable and did not explain the presentation and diagnosis...
April 19, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28264757/supplementation-of-sperm-media-with-zinc-d-aspartate-and-co-enzyme-q10-protects-bull-sperm-against-exogenous-oxidative-stress-and-improves-their-ability-to-support-embryo-development
#4
Vincenza Barbato, Riccardo Talevi, Sabrina Braun, Anna Merolla, Sam Sudhakaran, S Longobardi, Roberto Gualtieri
High levels of reactive oxygen species in the semen of infertile patients or spontaneously generated during in vitro sperm handling may impair sperm quality, fertilization and embryo developmental competence. We recently reported that zinc, d-aspartate and co-enzyme Q10, contained in the dietary supplement Genadis® (Merck Serono), have protective effects on human and bull sperm motility, lipid peroxidation and DNA fragmentation in vitro; furthermore, in bovine, treated spermatozoa had an improved ability to support embryo development...
March 7, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28177750/modulatory-role-of-co-enzyme-q10-on-methionine-and-choline-deficient-diet-induced-non-alcoholic-steatohepatitis-nash-in-albino-rats
#5
Dalia O Saleh, Rania F Ahmed, Mohamed M Amin
The present study aimed to evaluate the hepato-protective and neuro-protective activity of Co-enzyme Q10 (CoQ10) on non-alcoholic steatohepatitis (NASH) in albino rats induced by methionine and choline-deficient (MCD) diet. Rats were fed an MCD diet for 8 weeks to induce non-alcoholic steatohepatitis. CoQ10 (10 mg/(kg·day)(-1)) was orally administered for 2 consecutive weeks. Twenty-four hours after the last dose of the drug, the behavioral test, namely the activity cage test, was performed and the activity counts were recorded...
March 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28058114/protective-effects-of-co-enzyme-q10-on-thioacetamide-induced-acute-liver-damage-and-its-correlation-with-behavioral-biochemical-and-pathological-factors
#6
Soheil Ashkani-Esfahani, Fereshteh Bagheri, Yasaman Emami, Elmira Esmaeilzadeh, Negar Azarpira, Nazila Hassanabadi, Marzieh Keshtkar, Mojtaba Farjam, Omid Koohi-Hosseinabadi, Ali Noorafshan
BACKGROUND: Acute liver damage may be followed by biochemical, behavioral, and pathological alterations, which can result in serious complications and even death. OBJECTIVES: In this experimental study we determined whether coenzyme Q10 (CoQ10), a common supplementary medicine known to have protective, antioxidative, and anti-inflammatory effects in cells, has any protective effect against thioacetamide (TAA)-induced liver damage and its related neurobehavioral alterations in rats...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27794544/hsp70-expression-induced-by-co-enzyme-q10-protected-chicken-myocardial-cells-from-damage-and-apoptosis-under-in-vitro-heat-stress
#7
J Xu, S Tang, E Song, B Yin, D Wu, E Bao
The aim of this study was to investigate whether induction of Hsp70 expression by co-enzyme Q10 (Q10) treatment protects chicken primary myocardial cells (CPMCs) from damage and apoptosis in response to heat stress for 5 hours. Analysis of the expression and distribution of Hsp70 and the levels of the damage-related enzymes creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH), as well as pathological analysis showed that co-enzyme Q10 alleviated the damage caused to CPMCs during heat stress. Further, analysis of cell apoptosis and the expression of cleaved caspase-3 indicated that co-enzyme Q10 did have an anti-apoptotic role during heat stress...
May 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/27630504/comparative-evaluation-of-co-enzyme-q10-and-melaleuca-alternifolia-as-antioxidant-gels-in-treatment-of-chronic-periodontitis-a-clinical-study
#8
Chetan Purushottam Raut, Kunal S Sethi
BACKGROUND: Conventional nonsurgical periodontal therapy has been proven to be an effective treatment for patients with chronic periodontitis. Coenzyme Q10 and tea tree oil (TTO) are known to have potential therapeutic benefits in chronic periodontitis. AIMS: The aim of the study is to compare the efficacy of Coenzyme Q10 (Perio Q(®)) and tea tree oil (Melaleuca alternifolia) gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis...
July 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27503149/a-sex-difference-in-oxidative-stress-and-behavioral-suppression-induced-by-ethanol-withdrawal-in-rats
#9
Marianna E Jung, Daniel B Metzger
Ethanol withdrawal (EW) is referred to the abrupt termination of long-term heavy drinking, and provokes oxidative brain damage. Here, we investigated whether the cerebellum and hippocampus of female rats are less affected by prooxidant EW than male rats due to the antioxidant effect of 17β-estradiol (E2). Female and male rats received a four-week ethanol diet and three-week withdrawal per cycle for two cycles. Some female rats were ovariectomized with E2 or antioxidant (Vitamin E+Co-Q10) treatment. Measurements were cerebellum (Rotarod) and hippocampus (water-maze)-related behaviors, oxidative markers (O2(-), malondialdehyde, protein carbonyls), mitochondrial membrane swelling, and a key mitochondrial enzyme, cytochrome c oxidase (CcO)...
November 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27432748/obesity-induced-oocyte-mitochondrial-defects-are-partially-prevented-and-rescued-by-supplementation-with-co-enzyme-q10-in-a-mouse-model
#10
C E Boots, A Boudoures, W Zhang, A Drury, K H Moley
STUDY QUESTION: Does supplementation with co-enzyme Q10 (CoQ10) improve the oocyte mitochondrial abnormalities associated with obesity in mice? SUMMARY ANSWER: In an obese mouse model, CoQ10 improves the mitochondrial function of oocytes. WHAT IS KNOWN ALREADY: Obesity impairs oocyte quality. Oocytes from mice fed a high-fat/high-sugar (HF/HS) diet have abnormalities in mitochondrial distribution and function and in meiotic progression. STUDY DESIGN, SIZE, DURATION: Mice were randomly assigned to a normal, chow diet or an isocaloric HF/HS diet for 12 weeks...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27175889/purification-and-characterization-of-the-carbonic-anhydrase-enzyme-from-black-sea-trout-salmo-trutta-labrax-coruhensis-kidney-and-inhibition-effects-of-some-metal-ions-on-enzyme-activity
#11
Murat Kucuk, İlhami Gulcin
In this study, the carbonic anhydrase (CA) enzyme was purified from Black Sea trout (Salmo trutta Labrax Coruhensis) kidney with a specific activity of 603.77EU/mg and a yield of 35.5% using Sepharose-4B-l-tyrosine- sulphanilamide affinity column chromatography. For determining the enzyme purity and subunit molecular mass, sodiumdodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) was performed and single band was observed. The molecular mass of subunit was found approximately 29.71kDa. The optimum temperature, activation energy (Ea), activation enthalpy (ΔH) and Q10 values were obtained from Arrhenius plot...
June 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27136895/repurposing-atovaquone-targeting-mitochondrial-complex-iii-and-oxphos-to-eradicate-cancer-stem-cells
#12
Marco Fiorillo, Rebecca Lamb, Herbert B Tanowitz, Luciano Mutti, Marija Krstic-Demonacos, Anna Rita Cappello, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti
Atovaquone is an FDA-approved anti-malarial drug, which first became clinically available in the year 2000. Currently, its main usage is for the treatment of pneumocystis pneumonia (PCP) and/or toxoplasmosis in immune-compromised patients. Atovaquone is a hydroxy-1,4-naphthoquinone analogue of ubiquinone, also known as Co-enzyme Q10 (CoQ10). It is a well-tolerated drug that does not cause myelo-suppression. Mechanistically, it is thought to act as a potent and selective OXPHOS inhibitor, by targeting the CoQ10-dependence of mitochondrial complex III...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27087047/protective-effect-of-co-enzyme-q10-on-doxorubicin-induced-cardiomyopathy-of-rat-hearts
#13
Pei-Yu Chen, Chien-Wen Hou, Marthandam Asokan Shibu, Cecilia Hsuan Day, Peiying Pai, Zhao-Rong Liu, Tze-Yi Lin, Vijaya Padma Viswanadha, Chia-Hua Kuo, Chih-Yang Huang
Q10 is a powerful antioxidant often used in medical nutritional supplements for cancer treatment. This study determined whether Q10 could effectively prevent cardio-toxicity caused by doxorubicin treatment. Four week old SD rats were segregated into groups namely control, doxorubicin group (challenged with doxorubicin), Dox + Q10 group (with doxorubicin challenge and oral Q10 treatment), and Q10 group (with oral Q10 treatment). Doxorubicin groups received IP doxorubicin (2.5 mg/kg) every 3 days and Q10 groups received Q10 (10 mg/kg) every day...
February 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/27010352/p-coumaric-acid-a-novel-and-effective-biomarker-for-quantifying-hypoxic-stress-by-hilic-esi-ms
#14
Yuliya E Silina, Claudia Fink-Straube, Rainer G Hanselmann, Henrike Peuschel, Dietrich A Volmer
In this study, we report p-coumaric acid as novel and effective response marker for indirectly measuring the levels of hypoxia in normal primary bronchial epithelial cells. We developed a simple and rapid technique based on hydrophilic interaction chromatography-electrospray ionization-mass spectrometry (HILIC-ESI-MS). During 168h of hypoxia without induction of reactive oxygen species (ROS), an almost linear increase of p-coumaric acid levels was observed. We interpret the increasing p-coumaric acid concentrations during hypoxia as a result of cell damage, triggered by reduced co-enzyme Q10 levels, because the oxidative cascade was not able to supply sufficient energy...
May 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26918065/a-summary-of-a-cochrane-review-co-enzyme-q10-supplements-to-prevent-cardiovascular-disease
#15
Nancy Santesso
No abstract text is available yet for this article.
October 1, 2015: European Journal of Integrative Medicine
https://www.readbyqxmd.com/read/26787930/peanuts-as-functional-food-a-review
#16
REVIEW
Shalini S Arya, Akshata R Salve, S Chauhan
Peanut is an important crop grown worldwide. Commercially it is used mainly for oil production but apart from oil, the by-products of peanut contains many other functional compounds like proteins, fibers, polyphenols, antioxidants, vitamins and minerals which can be added as a functional ingredient into many processed foods. Recently it has also revealed that peanuts are excellent source of compounds like resveratrol, phenolic acids, flavonoids and phytosterols that block the absorption of cholesterol from diet...
January 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/26052873/the-use-of-complementary-and-alternative-medicine-in-hospitalized-patients-with-type-2-diabetes-mellitus-in-israel
#17
Ronit Koren, Ayelet Lerner, Amit Tirosh, Ronit Zaidenstein, Tomer Ziv-Baran, Ahuva Golik, Shlomit Koren
INTRODUCTION: The use of complementary and alternative medicine (CAM) has been on the rise in recent years in the general population, as well as among patients with chronic diseases such as diabetes mellitus. The aim of this study was to add information regarding the use of CAM in patients with type 2 diabetes mellitus (DM2) in Israel and explore possible interactions between CAM and prescription medication (PM). METHODS: This is a cross-sectional study based on questionnaires...
July 2015: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/25817210/identification-and-elimination-of-metabolic-bottlenecks-in-the-quinone-modification-pathway-for-enhanced-coenzyme-q10-production-in-rhodobacter-sphaeroides
#18
Wenqiang Lu, Lidan Ye, Xiaomei Lv, Wenping Xie, Jiali Gu, Zhaofeng Chen, Yongqiang Zhu, Aipeng Li, Hongwei Yu
In this report, UbiE and UbiH in the quinone modification pathway (QMP) were identified in addition to UbiG as bottleneck enzymes in the CoQ10 biosynthesis by Rhodobacter sphaeroides. The CoQ10 content was enhanced after co-overexpression of UbiE and UbiG, however, accompanied by the accumulation of the intermediate 10P-MMBQ. UbiH was then co-overexpressed to pull the metabolic flux towards downstream, resulting in an elevated CoQ10 productivity and decreased biomass. On the other hand, the expression levels of UbiE and UbiG were tuned to eliminate the intermediate accumulation, however at the sacrifice of productivity...
May 2015: Metabolic Engineering
https://www.readbyqxmd.com/read/25474484/co-enzyme-q10-supplementation-for-the-primary-prevention-of-cardiovascular-disease
#19
REVIEW
Nadine Flowers, Louise Hartley, Daniel Todkill, Saverio Stranges, Karen Rees
BACKGROUND: Cardiovascular disease (CVD) remains the number one cause of death and disability worldwide and public health interventions focus on modifiable risk factors, such as diet. Coenzyme Q10 (CoQ10) is an antioxidant that is naturally synthesised by the body and can also be taken as a dietary supplement. Studies have shown that a CoQ10 deficiency is associated with cardiovascular disease. OBJECTIVES: To determine the effects of coenzyme Q10 supplementation as a single ingredient for the primary prevention of CVD...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25262434/effect-of-a-hydrophilic-and-a-hydrophobic-statin-on-cardiac-salvage-after-st-elevated-acute-myocardial-infarction-a-pilot-study
#20
RANDOMIZED CONTROLLED TRIAL
Tadasuke Chitose, Seigo Sugiyama, Kenji Sakamoto, Hideki Shimomura, Takuro Yamashita, Jun Hokamaki, Ryusuke Tsunoda, Shinya Shiraishi, Yasuyuki Yamashita, Hisao Ogawa
OBJECTIVE: Early statin therapy after acute coronary syndrome reduces atherothrombotic vascular events. This study aimed to compare the effects of hydrophilic and hydrophobic statins on myocardial salvage and left ventricular (LV) function in patients with ST-elevated myocardial infarction (STEMI). METHODS: Seventy-five STEMI patients who had received emergency reperfusion therapy were enrolled and randomized into the hydrophilic statin group (rosuvastatin; 5 mg/day, n = 38) and hydrophobic statin group (atorvastatin; 10 mg/day, n = 37) for 6 months...
November 2014: Atherosclerosis
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