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co enzyme q10

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https://www.readbyqxmd.com/read/27794544/hsp70-expression-induced-by-co-enzyme-q10-protected-chicken-myocardial-cells-from-damage-and-apoptosis-under-in-vitro-heat-stress
#1
J Xu, S Tang, E Song, B Yin, D Wu, E Bao
The aim of this study was to investigate whether induction of Hsp70 expression by co-enzyme Q10 (Q10) treatment protects chicken primary myocardial cells (CPMCs) from damage and apoptosis in response to heat stress for 5 hours. Analysis of the expression and distribution of Hsp70 and the levels of the damage-related enzymes creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH), as well as pathological analysis showed that co-enzyme Q10 alleviated the damage caused to CPMCs during heat stress. Further, analysis of cell apoptosis and the expression of cleaved caspase-3 indicated that co-enzyme Q10 did have an anti-apoptotic role during heat stress...
October 28, 2016: Poultry Science
https://www.readbyqxmd.com/read/27630504/comparative-evaluation-of-co-enzyme-q10-and-melaleuca-alternifolia-as-antioxidant-gels-in-treatment-of-chronic-periodontitis-a-clinical-study
#2
Chetan Purushottam Raut, Kunal S Sethi
BACKGROUND: Conventional nonsurgical periodontal therapy has been proven to be an effective treatment for patients with chronic periodontitis. Coenzyme Q10 and tea tree oil (TTO) are known to have potential therapeutic benefits in chronic periodontitis. AIMS: The aim of the study is to compare the efficacy of Coenzyme Q10 (Perio Q(®)) and tea tree oil (Melaleuca alternifolia) gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis...
July 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27503149/a-sex-difference-in-oxidative-stress-and-behavioral-suppression-induced-by-ethanol-withdrawal-in-rats
#3
Marianna E Jung, Daniel B Metzger
Ethanol withdrawal (EW) is referred to the abrupt termination of long-term heavy drinking, and provokes oxidative brain damage. Here, we investigated whether the cerebellum and hippocampus of female rats are less affected by prooxidant EW than male rats due to the antioxidant effect of 17β-estradiol (E2). Female and male rats received a four-week ethanol diet and three-week withdrawal per cycle for two cycles. Some female rats were ovariectomized with E2 or antioxidant (Vitamin E+Co-Q10) treatment. Measurements were cerebellum (Rotarod) and hippocampus (water-maze)-related behaviors, oxidative markers (O2(-), malondialdehyde, protein carbonyls), mitochondrial membrane swelling, and a key mitochondrial enzyme, cytochrome c oxidase (CcO)...
November 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27432748/obesity-induced-oocyte-mitochondrial-defects-are-partially-prevented-and-rescued-by-supplementation-with-co-enzyme-q10-in-a-mouse-model
#4
C E Boots, A Boudoures, W Zhang, A Drury, K H Moley
STUDY QUESTION: Does supplementation with co-enzyme Q10 (CoQ10) improve the oocyte mitochondrial abnormalities associated with obesity in mice? SUMMARY ANSWER: In an obese mouse model, CoQ10 improves the mitochondrial function of oocytes. WHAT IS KNOWN ALREADY: Obesity impairs oocyte quality. Oocytes from mice fed a high-fat/high-sugar (HF/HS) diet have abnormalities in mitochondrial distribution and function and in meiotic progression. STUDY DESIGN, SIZE, DURATION: Mice were randomly assigned to a normal, chow diet or an isocaloric HF/HS diet for 12 weeks...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27175889/purification-and-characterization-of-the-carbonic-anhydrase-enzyme-from-black-sea-trout-salmo-trutta-labrax-coruhensis-kidney-and-inhibition-effects-of-some-metal-ions-on-enzyme-activity
#5
Murat Kucuk, İlhami Gulcin
In this study, the carbonic anhydrase (CA) enzyme was purified from Black Sea trout (Salmo trutta Labrax Coruhensis) kidney with a specific activity of 603.77EU/mg and a yield of 35.5% using Sepharose-4B-l-tyrosine- sulphanilamide affinity column chromatography. For determining the enzyme purity and subunit molecular mass, sodiumdodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) was performed and single band was observed. The molecular mass of subunit was found approximately 29.71kDa. The optimum temperature, activation energy (Ea), activation enthalpy (ΔH) and Q10 values were obtained from Arrhenius plot...
June 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27136895/repurposing-atovaquone-targeting-mitochondrial-complex-iii-and-oxphos-to-eradicate-cancer-stem-cells
#6
Marco Fiorillo, Rebecca Lamb, Herbert B Tanowitz, Luciano Mutti, Marija Krstic-Demonacos, Anna Rita Cappello, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti
Atovaquone is an FDA-approved anti-malarial drug, which first became clinically available in the year 2000. Currently, its main usage is for the treatment of pneumocystis pneumonia (PCP) and/or toxoplasmosis in immune-compromised patients. Atovaquone is a hydroxy-1,4-naphthoquinone analogue of ubiquinone, also known as Co-enzyme Q10 (CoQ10). It is a well-tolerated drug that does not cause myelo-suppression. Mechanistically, it is thought to act as a potent and selective OXPHOS inhibitor, by targeting the CoQ10-dependence of mitochondrial complex III...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27087047/protective-effect-of-co-enzyme-q10-on-doxorubicin-induced-cardiomyopathy-of-rat-hearts
#7
Pei-Yu Chen, Chien-Wen Hou, Marthandam Asokan Shibu, Cecilia Hsuan Day, Peiying Pai, Zhao-Rong Liu, Tze-Yi Lin, Vijaya Padma Viswanadha, Chia-Hua Kuo, Chih-Yang Huang
Q10 is a powerful antioxidant often used in medical nutritional supplements for cancer treatment. This study determined whether Q10 could effectively prevent cardio-toxicity caused by doxorubicin treatment. Four week old SD rats were segregated into groups namely control, doxorubicin group (challenged with doxorubicin), Dox + Q10 group (with doxorubicin challenge and oral Q10 treatment), and Q10 group (with oral Q10 treatment). Doxorubicin groups received IP doxorubicin (2.5 mg/kg) every 3 days and Q10 groups received Q10 (10 mg/kg) every day...
April 18, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27010352/p-coumaric-acid-a-novel-and-effective-biomarker-for-quantifying-hypoxic-stress-by-hilic-esi-ms
#8
Yuliya E Silina, Claudia Fink-Straube, Rainer G Hanselmann, Henrike Peuschel, Dietrich A Volmer
In this study, we report p-coumaric acid as novel and effective response marker for indirectly measuring the levels of hypoxia in normal primary bronchial epithelial cells. We developed a simple and rapid technique based on hydrophilic interaction chromatography-electrospray ionization-mass spectrometry (HILIC-ESI-MS). During 168h of hypoxia without induction of reactive oxygen species (ROS), an almost linear increase of p-coumaric acid levels was observed. We interpret the increasing p-coumaric acid concentrations during hypoxia as a result of cell damage, triggered by reduced co-enzyme Q10 levels, because the oxidative cascade was not able to supply sufficient energy...
May 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26918065/a-summary-of-a-cochrane-review-co-enzyme-q10-supplements-to-prevent-cardiovascular-disease
#9
Nancy Santesso
No abstract text is available yet for this article.
October 1, 2015: European Journal of Integrative Medicine
https://www.readbyqxmd.com/read/26787930/peanuts-as-functional-food-a-review
#10
REVIEW
Shalini S Arya, Akshata R Salve, S Chauhan
Peanut is an important crop grown worldwide. Commercially it is used mainly for oil production but apart from oil, the by-products of peanut contains many other functional compounds like proteins, fibers, polyphenols, antioxidants, vitamins and minerals which can be added as a functional ingredient into many processed foods. Recently it has also revealed that peanuts are excellent source of compounds like resveratrol, phenolic acids, flavonoids and phytosterols that block the absorption of cholesterol from diet...
January 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/26052873/the-use-of-complementary-and-alternative-medicine-in-hospitalized-patients-with-type-2-diabetes-mellitus-in-israel
#11
Ronit Koren, Ayelet Lerner, Amit Tirosh, Ronit Zaidenstein, Tomer Ziv-Baran, Ahuva Golik, Shlomit Koren
INTRODUCTION: The use of complementary and alternative medicine (CAM) has been on the rise in recent years in the general population, as well as among patients with chronic diseases such as diabetes mellitus. The aim of this study was to add information regarding the use of CAM in patients with type 2 diabetes mellitus (DM2) in Israel and explore possible interactions between CAM and prescription medication (PM). METHODS: This is a cross-sectional study based on questionnaires...
July 2015: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/25817210/identification-and-elimination-of-metabolic-bottlenecks-in-the-quinone-modification-pathway-for-enhanced-coenzyme-q10-production-in-rhodobacter-sphaeroides
#12
Wenqiang Lu, Lidan Ye, Xiaomei Lv, Wenping Xie, Jiali Gu, Zhaofeng Chen, Yongqiang Zhu, Aipeng Li, Hongwei Yu
In this report, UbiE and UbiH in the quinone modification pathway (QMP) were identified in addition to UbiG as bottleneck enzymes in the CoQ10 biosynthesis by Rhodobacter sphaeroides. The CoQ10 content was enhanced after co-overexpression of UbiE and UbiG, however, accompanied by the accumulation of the intermediate 10P-MMBQ. UbiH was then co-overexpressed to pull the metabolic flux towards downstream, resulting in an elevated CoQ10 productivity and decreased biomass. On the other hand, the expression levels of UbiE and UbiG were tuned to eliminate the intermediate accumulation, however at the sacrifice of productivity...
May 2015: Metabolic Engineering
https://www.readbyqxmd.com/read/25474484/co-enzyme-q10-supplementation-for-the-primary-prevention-of-cardiovascular-disease
#13
REVIEW
Nadine Flowers, Louise Hartley, Daniel Todkill, Saverio Stranges, Karen Rees
BACKGROUND: Cardiovascular disease (CVD) remains the number one cause of death and disability worldwide and public health interventions focus on modifiable risk factors, such as diet. Coenzyme Q10 (CoQ10) is an antioxidant that is naturally synthesised by the body and can also be taken as a dietary supplement. Studies have shown that a CoQ10 deficiency is associated with cardiovascular disease. OBJECTIVES: To determine the effects of coenzyme Q10 supplementation as a single ingredient for the primary prevention of CVD...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25262434/effect-of-a-hydrophilic-and-a-hydrophobic-statin-on-cardiac-salvage-after-st-elevated-acute-myocardial-infarction-a-pilot-study
#14
RANDOMIZED CONTROLLED TRIAL
Tadasuke Chitose, Seigo Sugiyama, Kenji Sakamoto, Hideki Shimomura, Takuro Yamashita, Jun Hokamaki, Ryusuke Tsunoda, Shinya Shiraishi, Yasuyuki Yamashita, Hisao Ogawa
OBJECTIVE: Early statin therapy after acute coronary syndrome reduces atherothrombotic vascular events. This study aimed to compare the effects of hydrophilic and hydrophobic statins on myocardial salvage and left ventricular (LV) function in patients with ST-elevated myocardial infarction (STEMI). METHODS: Seventy-five STEMI patients who had received emergency reperfusion therapy were enrolled and randomized into the hydrophilic statin group (rosuvastatin; 5 mg/day, n = 38) and hydrophobic statin group (atorvastatin; 10 mg/day, n = 37) for 6 months...
November 2014: Atherosclerosis
https://www.readbyqxmd.com/read/25253934/coenzyme-q10-abrogated-the-28-days-aluminium-chloride-induced-oxidative-changes-in-rat-cerebral-cortex
#15
Anuradha S Majumdar, Abhijit Nirwane, Rahul Kamble
OBJECTIVE: The present study was designed to elucidate the impact of oral administration of aluminium chloride for 28 days with respect to oxidative stress in the cerebral cortex of female rats. Further, to investigate the potentials of Coenzyme (Co) Q10 (4, 8, and 12 mg/kg, i.p.) in mitigating the detrimental changes. MATERIALS AND METHODS: Biochemical estimations of cerebral lipid peroxidation (LPO), reduced glutathione (GSH), vitamin E and activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were carried out after 28 days of aluminium chloride (AlCl3) and Co Q10 exposures along with histopathological examination of cerebral cortex of the rats...
May 2014: Toxicology International
https://www.readbyqxmd.com/read/25023008/biventricular-non-compaction-hypertrophic-cardiomyopathy-in-association-with-congenital-complete-heart-block-and-type-i-mitochondrial-complex-deficiency
#16
Ranjana Dhar, William Reardon, Colin J McMahon
We report a baby girl with an antenatal diagnosis of biventricular non-compaction and complete heart block detected at 22 weeks' gestation. Postnatal echocardiography confirmed severe biventricular non-compaction hypertrophic cardiomyopathy, multiple muscular ventricular septal defects, and mild-moderate pulmonary valve stenosis. Skeletal muscle biopsy confirmed complex 1 mitochondrial respiratory chain deficiency. An epicardial VVI pacemaker was implanted on day 3 of life and revised at 7 years of age. She remains stable at 8 years of age following pacing and medical treatment with carvedilol, aspirin, co-enzyme Q10, and carnitine...
June 2015: Cardiology in the Young
https://www.readbyqxmd.com/read/25019065/treatments-for-biomedical-abnormalities-associated-with-autism-spectrum-disorder
#17
REVIEW
Richard Eugene Frye, Daniel A Rossignol
Recent studies point to the effectiveness of novel treatments that address physiological abnormalities associated with autism spectrum disorder (ASD). This is significant because safe and effective treatments for ASD remain limited. These physiological abnormalities as well as studies addressing treatments of these abnormalities are reviewed in this article. Treatments commonly used to treat mitochondrial disease have been found to improve both core and associated ASD symptoms. Double-blind, placebo-controlled (DBPC) studies have investigated l-carnitine and a multivitamin containing B vitamins, antioxidants, vitamin E, and co-enzyme Q10 while non-blinded studies have investigated ubiquinol...
2014: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/24932457/mitochondrial-dysfunction-in-obesity-potential-benefit-and-mechanism-of-co-enzyme-q10-supplementation-in-metabolic-syndrome
#18
REVIEW
Md Ashraful Alam, Md Mahbubur Rahman
Co-enzyme Q10 (Co-Q10) is an essential component of the mitochondrial electron transport chain. Most cells are sensitive to co-enzyme Q10 (Co-Q10) deficiency. This deficiency has been implicated in several clinical disorders such as heart failure, hypertension, Parkinson's disease and obesity. The lipid lowering drug statin inhibits conversion of HMG-CoA to mevalonate and lowers plasma Co-Q10 concentrations. However, supplementation with Co-Q10 improves the pathophysiological condition of statin therapy. Recent evidence suggests that Co-Q10 supplementation may be useful for the treatment of obesity, oxidative stress and the inflammatory process in metabolic syndrome...
2014: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/24882509/epicardial-fat-tissue-thickness-is-correlated-with-diminished-levels-of-co-enzyme-q10-a-major-antioxidant-molecule-among-hemodialysis-patients
#19
Beyza Macunluoglu, Aydin Atakan, Elif Ari, Yüksel Kaya, Cigdem Kaspar, Halit Demir, Hamit Hakan Alp
OBJECTIVES: Accelerated atherosclerosis is the major cause of mortality in patients on chronic maintenance hemodialysis (HD). Epicardial fat tissue (EFT) is a new risk factor in cardiovascular disease (CVD). The aim of this study was to evaluate the relation between plasma coenzyme Q10 levels (Co-Q10) which is a potent physiologic antioxidant and EFT thickness in HD patients. DESIGN AND METHODS: Seventy one chronic HD patients and 65 age and sex matched healthy individuals were included in the study...
September 2014: Clinical Biochemistry
https://www.readbyqxmd.com/read/24583329/european-consumer-attitudes-on-the-associated-health-benefits-of-neutraceutical-containing-processed-meats-using-co-enzyme-q10-as-a-sample-functional-ingredient
#20
Brian D Tobin, Maurice G O'Sullivan, Ruth Hamill, Joseph P Kerry
This study accumulated European consumer attitudes towards processed meats and their use as a functional food. A survey was set up using an online web-application to gather information on consumer perception of processed meats as well as neutraceutical-containing processed meats. 548 responses were obtained and statistical analysis was carried out using a statistical software package. Data was summarized as frequencies for each question and statistical differences analyzed using the Chi-Square statistical test with a significance level of 5% (P<0...
June 2014: Meat Science
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