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thioctic acid

I A Volchegorskii, I Yu Miroshnichenko, L M Rassokhina, R M Faizullin, K E Pryakhina
AIM: To perform a comparative study of anxiolytic and antidepressant effects of derivatives of 3-oxypyridine and succinic acid (emoxipine, reamberin and mexidol) in experimental diabetes mellitus. MATERIAL AND METHODS: An effect of emoxipine, reamberin and mexidol on manifestations of anxiety in 'elevated plus maze' (EPM) and duration of 'desperate behavior' (DB) in Porsolt test in rats with alloxan diabetes during medication course was studied. Alpha-lipoic (thioctic) acid (α-LA) was used as a reference drug...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Nur Mustafaoglu, Tanyel Kiziltepe, Basar Bilgicer
Small dimensions of gold nanoparticles (AuNPs) necessitate antibodies to be immobilized in an oriented fashion in order to conserve their antigen binding activity for proper function. In this study, we used the previously described UV-NBS method to site-specifically incorporate a thioctic acid (TA) functionality into antibodies at the conserved nucleotide-binding site (NBS). Modified antibodies were immobilized on the AuNP surface in an oriented manner utilizing the newly incorporated TA functionality while maintaining the antibody structure and activity...
June 29, 2017: Nanoscale
Vida Mohammadi, Sirous Dehghani, Gholamreza Askari
Although several animal and human studies have investigated the effect of alpha-lipoic acid (ALA) on blood pressure (BP), these findings are inconsistent. This systematic review of randomized clinical trials was conducted to summarize the evidence on the effect of ALA on BP. PubMed, SCOPUS, and Google Scholar databases were searched based on MESH term ("Thioctic acid" in combination with "Hypertension" and "Blood pressure") to identify related papers published up to December 2015. We summarized the results of the relevant studies in this review...
2017: International Journal of Preventive Medicine
Sarah Craig, Rachel Urwin, Mark Wilkinson
No abstract text is available yet for this article.
June 2017: Contact Dermatitis
I A Strokov, A S Phokina
α-Lipoic acid, or thioctic acid, (ALA) is the most applicable pharmacological drug for treatment of diabetic polyneuropathy. The article explores the results of experimental studies on the α-lipoic acid effect on mechanisms of peripheral nerves affection in hyperglycemia as well as the data of numerous randomized controlled trials and meta-analyses on studying ALA efficacy in symptomatic diabetic polyneuropathy. It has been shown that amelioration of patients with diabetic polyneuropathy is observed both for ALA infusions and tableted form of the drug...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Kavitha Buntara Sanjeeva, Ilaria Tirotta, Vijith Kumar, Francesca Baldelli Bombelli, Giancarlo Terraneo, Pierangelo Metrangolo
The synthesis and self-assembly capabilities of a new halogen-bond donor ligand, 2,3,5,6-tetrafluoro-4-iodophenyl 5-(1,2-dithiolan-3-yl)pentanoate (1), are reported. The crystal structure of ligand (1) and the formation of a cocrystal with 1,2-di(4-pyridyl)ethylene, (1)·(2), both show halogen bonds involving the 4-iodotetrafluorobenzene moiety. Ligand (1), being a self-complementary unit, forms an infinite halogen-bonded chain driven by the S...I synthon, while the cocrystal (1)·(2) self-assembles into a discrete trimeric entity driven by the N...
April 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
Ehsan Moaseri, Robert J Stover, Behzad Changalvaie, Alexis J Cepeda, Thomas M Truskett, Konstantin V Sokolov, Keith P Johnston
Reversible NIR-active nanoparticle clusters with controlled size from 20 to 100 nm were assembled from 5 nm gold nanoparticles (Au NP), with either citrate (CIT) or various binary ligands on the surface, by tuning the electrostatic repulsion and the hydrogen bonding via pH. The nanoclusters were bound together by vdW forces between the cores and the hydrogen bonds between the surface ligands and dissociated to primary nanoparticles over a period of 20 days at pH 5 and at pH 7. When high levels of citrate ligands were used on the primary particle surfaces, the large particle spacings in the nanoclusters led to only modest NIR extinction...
April 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
M C Perez-Matos, M C Morales-Alvarez, C O Mendivil
Diabetic polyneuropathy (DPN) encompasses multiple syndromes with a common pathogenesis. Glycemic control shows a limited correlation with DPN, arguing in favor of major involvement of other factors, one of which is alterations of lipid and lipoprotein metabolism. Consistent associations have been found between plasma triglycerides/remnant lipoproteins and the risk of DPN. Studies in cultured nerve tissue or in murine models of diabetes have unveiled mechanisms linking lipid metabolism to DPN. Deficient insulin action increases fatty acids flux to nerve cells, inducing mitochondrial dysfunction, anomalous protein kinase C signaling, and perturbations in the physicochemical properties of the plasma membrane...
2017: Journal of Diabetes Research
Li Chen, Jiaolong Wang, Glen Mouser, Yan Chun Li, Geno Marcovici
Androgenetic alopecia (AGA) affects approximately 70% of men and 40% of women in an age-dependent manner and is partially mediated by androgen hormones. Benign prostatic hyperplasia (BPH) similarly affects 50% of the male population, rising by 10% each decade. Finasteride inhibits 5-alpha reductase (5AR) and is used to treat both disorders, despite offering limited clinical benefits accompanied by significant adverse side effects. Building on our previous work demonstrating the efficacy of naturally derived 5AR inhibitors (such as stigmasterol and beta sitosterol), we hypothesize that targeting 5AR as well as inflammatory pathways may yield improved efficacy in AGA and BPH...
June 2016: Phytotherapy Research: PTR
Sushma Kalmodia, Suryanarayanan Vandhana, B R Tejaswini Rama, Balasubramanyam Jayashree, T Sreenivasan Seethalakshmi, Vetrivel Umashankar, Wenrong Yang, Colin J Barrow, Subramanian Krishnakumar, Sailaja V Elchuri
BACKGROUND: Functionalized gold nanoparticles are emerging as a promising nanocarrier for target specific delivery of the therapeutic molecules in a cancer cell, as a result it targeted selectively to the cancer cell and minimized the off-target effect. The functionalized nanomaterial (bio conjugate) brings novel functional properties, for example, the high payload of anticancer, antioxidant molecules and selective targeting of the cancer molecular markers. The current study reported the synthesis of multifunctional bioconjugate (GNPs-Pep-A) to target the cancer cell...
2016: Cancer Nanotechnology
Julie Leysen, Olivier Aerts
No abstract text is available yet for this article.
March 2016: Contact Dermatitis
Manish S Hudlikar, Xiuru Li, Ivan A Gagarinov, Nagesh Kolishetti, Margreet A Wolfert, Geert-Jan Boons
A major objective of nanomedicine is to combine in a controlled manner multiple functional entities into a single nanoscale device to target particles with great spatial precision, thereby increasing the selectivity and potency of therapeutic drugs. A multifunctional nanoparticle is described for controlled conjugation of a cytotoxic drug, a cancer cell targeting ligand, and an imaging moiety. The approach is based on the chemical synthesis of polyethylene glycol that at one end is modified by a thioctic acid for controlled attachment to a gold core...
January 22, 2016: Chemistry: a European Journal
Chung-Yi Su, Tung-Han Yang, Vitaly Gurylev, Sheng-Hsin Huang, Jenn-Ming Wu, Tsong-Pyng Perng
We fabricated a photocatalytic Au@ZnO@PC (polycarbonate) nanoreactor composed of monolayered Au nanoparticles chemisorbed on conformal ZnO nanochannel arrays within the PC membrane. A commercial PC membrane was used as the template for deposition of a ZnO shell into the pores by atomic layer deposition (ALD). Thioctic acid (TA) with sufficient steric stabilization was used as a molecular linker for functionalization of Au nanoparticles in a diameter of 10 nm. High coverage of Au nanoparticles anchored on the inner wall of ZnO nanochannels greatly improved the photocatalytic activity for degradation of Rhodamine B...
October 2, 2015: Nanotechnology
Lukas Stolzer, Antonina Vigovskaya, Christopher Barner-Kowollik, Ljiljana Fruk
A photochemical approach based on nitrile imine-mediated tetrazole-ene cycloaddition is introduced to functionalize gold nanorods with biomolecules. For this purpose, a bifunctional, photoreactive linker containing thioctic acid as the Au anchoring group and a tetrazole moiety for the light-induced reaction with maleimide-capped DNA was prepared. The tetrazole-based reaction on the nanoparticles' surface results in a fluorescent pyrazoline product allowing for the spectroscopic monitoring of the reaction. This first example of nitrile imine-mediated tetrazole-ene cycloaddition (NITEC)-mediated biofunctionalization of Au nanorods paves the way for the attachment of sensitive biomolecules, such as antibodies and other proteins, under mild conditions and expands the toolbox for the tailoring of nanomaterials...
October 5, 2015: Chemistry: a European Journal
Eun-Yeong Kim, Keewon Yu, Kyungmi Choi, Hyung Eun Yu, Soo Jin Oh, Kiho Lee
The objective of the present work was to investigate the potential for pharmacokinetic drug-drug interactions between glimepiride (GMP) and piperazine dithioctate (PDT) in rats to support the development of an orally combined product of the two drugs. An LC-MS/MS bioanalytical method was developed for simultaneous quantification of GMP and thioctic acid (TA) in rat plasma. The accuracy, precision, linearity, selectivity, and recovery were all within an acceptable range. The oral plasma exposure of the GMP solution was more than 14-times greater than that of the GMP suspension at a dose of 0...
2015: Biological & Pharmaceutical Bulletin
Seyed Khosrow Tayebati, Daniele Tomassoni, Lorenzo Di Cesare Mannelli, Francesco Amenta
Endothelial cells represent an important vascular site of signaling and development of damage during ischemia, inflammation and other pathological conditions. Excessive reactive oxygen species production causes pathological activation of endothelium including exposure of cell to adhesion molecules. Intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) are members of the immunoglobulin super-family which are present on the surface of endothelial cells...
2016: Clinical and Experimental Hypertension: CHE
C Gómez-Anquela, T García-Mendiola, José M Abad, M Pita, F Pariente, E Lorenzo
Nanometric size gold nanoparticles capped with thiotic acid are used to coordinate with the Zn (II) present in the catalytic center of Alcohol Dehydrogenase (ADH). In combination with the NADH oxidation molecular catalyst Azure A, electrografted onto carbon screen-printed electrodes, they are used as scaffold electrodes for the construction of a very efficient ethanol biosensor. The final biosensing device exhibits a highly efficient ethanol oxidation with low overpotential of -0.25 V besides a very good analytical performance with a detection limit of 0...
December 2015: Bioelectrochemistry
V V Shilov, S M Nikonova, E L Lashina
The study proved important role of antioxidants in combined therapy for patients with vibration disease caused by general and local vibration. Findings are positive influence of thioctic acid on amelioration of pain and angiodystonia, supported by clinical and functional investigations.
2015: Meditsina Truda i Promyshlennaia Ekologiia
Jimin Kahng, Tae Kwan Kim, Eun Yong Chung, Yee Suk Kim, Jeong Yeon Moon
OBJECTIVE: To investigate the antiallodynic effects of thioctic acid in vincristine-induced neuropathy in rats. METHODS: Neuropathy was induced in Sprague-Dawley rats via vincristine intraperitoneal injection. After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid. Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180 min after treatment...
June 2015: Journal of International Medical Research
Nikolaos Papanas, Dan Ziegler
INTRODUCTION: Neuropathy is a serious complication of diabetes. Its management focuses on glycaemic control, multifactorial cardiovascular risk intervention, pathogenesis-oriented therapy, and analgesics where needed. AREAS COVERED: The objective of this review is assessment of efficacy and safety of α lipoic acid (ALA, also thioctic acid) in pathogenesis-oriented treatment of diabetic neuropathy. The mechanisms of action of ALA in experimental diabetic neuropathy include reduction of oxidative stress along with improvement in nerve blood flow, nerve conduction velocity, and several other measures of nerve function...
December 2014: Expert Opinion on Pharmacotherapy
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