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https://www.readbyqxmd.com/read/29863705/-therapy-of-myofascial-pain-syndrome-face-with-thioctic-acid
#1
O A Shavlovskaya, N M Fokina
Authors present a case-report of a 36-year-old patient with pain syndrome in the face region (craniomandibular dysfunction with occlusive disorders) involving pericranial muscles and shoulder girdle muscles. Thioctic acid was prescribed as a basic therapy, and relaxation tire, mimic gymnastics, post-isometric relaxation, vitamin and mineral complex were additionally used. Thioctic acid was prescribed according to the following scheme: stage I - intravenous injections of thioctic acid (600 mg/daily, 5 procedures, every other day); stage II - oral administration of the drug in the dose of 600 mg/daily for 3 months...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29849866/r-thioctic-acid-effects-on-oxidative-stress-and-peripheral-neuropathy-in-type-ii-diabetic-patients-preliminary-results-by-electron-paramagnetic-resonance-and-electroneurography
#2
Simona Mrakic-Sposta, Alessandra Vezzoli, Luca Maderna, Francesca Gregorini, Michela Montorsi, Sarah Moretti, Fulvia Greco, Emanuela Cova, Maristella Gussoni
Objectives: Diabetic neuropathy is the most common complication of diabetes. The idea of alterations in energy metabolism in diabetes is emerging. The biogenic antioxidant R(+)-thioctic acid has been successfully used in the treatment of diabetic polyneuropathic (DPN) patients. Methods: The effects of R(+)-thioctic acid (1 tablet, 1.6 g) administration were evaluated in 12 DPN patients at baseline and at 15, 30, 60, and 120 administration days throughout the assessment of oxidative stress (OxS); ROS production rate by electron paramagnetic resonance (EPR) technique; and oxidative damage biomarkers (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PC)), electroneurography (ENG) and visual analogue scale...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29246754/thioctic-acid-in-oral-submucous-fibrosis-india-s-disease-a-better-tomorrow
#3
G P Bhandarkar, K V Shetty, A Kulkarni
Oral submucous fibrosis (OSMF), because of its common occurrence in Indian population is known as India's disease. Regardless of diagnostic and therapeutic developments, oral potentially malignant disorders (PMD) and cancers are disseminating at a distressing rate. There is this prerequisite for unrelenting determination to find out apt treatment options so that malignant transformation may be prevented and more so the prevailing morbidity and mortality. Considering the frequency with which oral submucous fibrosis undergoes malignant transformation with free radicals playing a major part, the role of antioxidants in general and thioctic acid also known as alpha lipoic acid (ALA) in particular need to be studied in these individuals...
April 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29043297/clinical-efficacy-of-alprostadil-combined-with-%C3%AE-lipoic-acid-in-the-treatment-of-elderly-patients-with-diabetic-nephropathy
#4
Yan Hong, Jianyun Peng, Xiaoping Cai, Xiaoru Zhang, Yifei Liao, Lejian Lan
OBJECTIVE: To evaluate the effect and toxicity of alprostadil combined with thioctic acid injection in the treatment of patients with diabetic nephropathy (DN). METHODS: Sixty two patients with DN were included in this study and randomly divided into control group (n=32) and experiment group (n=30). Patients in the control group were given alprostadil 20ug+NS 100ml ivgtt, qd and patients in the experiment group were given alprostadil 20ug+NS 100ml ivgtt combined with thioctic acid injection of 0...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28638031/-anxiolytic-and-antidepressant-effects-of-emoxipine-reamberin-and-mexidol-in-experimental-diabetes-mellitus
#5
I A Volchegorskii, I Yu Miroshnichenko, L M Rassokhina, R M Faizullin, K E Pryakhina
AIM: To perform a comparative study of anxiolytic and antidepressant effects of derivatives of 3-oxypyridine and succinic acid (emoxipine, reamberin and mexidol) in experimental diabetes mellitus. MATERIAL AND METHODS: An effect of emoxipine, reamberin and mexidol on manifestations of anxiety in 'elevated plus maze' (EPM) and duration of 'desperate behavior' (DB) in Porsolt test in rats with alloxan diabetes during medication course was studied. Alpha-lipoic (thioctic) acid (α-LA) was used as a reference drug...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28613339/site-specific-conjugation-of-an-antibody-on-a-gold-nanoparticle-surface-for-one-step-diagnosis-of-prostate-specific-antigen-with-dynamic-light-scattering
#6
Nur Mustafaoglu, Tanyel Kiziltepe, Basar Bilgicer
Small dimensions of gold nanoparticles (AuNPs) necessitate antibodies to be immobilized in an oriented fashion in order to conserve their antigen binding activity for proper function. In this study, we used the previously described UV-NBS method to site-specifically incorporate a thioctic acid (TA) functionality into antibodies at the conserved nucleotide-binding site (NBS). Modified antibodies were immobilized on the AuNP surface in an oriented manner utilizing the newly incorporated TA functionality while maintaining the antibody structure and activity...
June 29, 2017: Nanoscale
https://www.readbyqxmd.com/read/28584615/does-alpha-lipoic-acid-supplement-regulate-blood-pressure-a-systematic-review-of-randomized-double-blind-placebo-controlled-clinical-trials
#7
REVIEW
Vida Mohammadi, Sirous Dehghani, Gholamreza Askari
Although several animal and human studies have investigated the effect of alpha-lipoic acid (ALA) on blood pressure (BP), these findings are inconsistent. This systematic review of randomized clinical trials was conducted to summarize the evidence on the effect of ALA on BP. PubMed, SCOPUS, and Google Scholar databases were searched based on MESH term ("Thioctic acid" in combination with "Hypertension" and "Blood pressure") to identify related papers published up to December 2015. We summarized the results of the relevant studies in this review...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28497636/contact-allergy-to-thioctic-acid-present-in-hypromellose-%C3%A2-eye-drops
#8
Sarah Craig, Rachel Urwin, Mark Wilkinson
No abstract text is available yet for this article.
June 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28399096/-%C3%AE-lipoic-acid-as-the-main-pharmacological-drug-for-in-and-outpatient-treatment-of-diabetic-polyneuropathy
#9
I A Strokov, A S Phokina
α-Lipoic acid, or thioctic acid, (ALA) is the most applicable pharmacological drug for treatment of diabetic polyneuropathy. The article explores the results of experimental studies on the α-lipoic acid effect on mechanisms of peripheral nerves affection in hyperglycemia as well as the data of numerous randomized controlled trials and meta-analyses on studying ALA efficacy in symptomatic diabetic polyneuropathy. It has been shown that amelioration of patients with diabetic polyneuropathy is observed both for ALA infusions and tableted form of the drug...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28362288/crystallographic-insights-into-the-structural-aspects-of-thioctic-acid-based-halogen-bond-donor-for-the-functionalization-of-gold-nanoparticles
#10
Kavitha Buntara Sanjeeva, Ilaria Tirotta, Vijith Kumar, Francesca Baldelli Bombelli, Giancarlo Terraneo, Pierangelo Metrangolo
The synthesis and self-assembly capabilities of a new halogen-bond donor ligand, 2,3,5,6-tetrafluoro-4-iodophenyl 5-(1,2-dithiolan-3-yl)pentanoate (1), are reported. The crystal structure of ligand (1) and the formation of a cocrystal with 1,2-di(4-pyridyl)ethylene, (1)·(2), both show halogen bonds involving the 4-iodotetrafluorobenzene moiety. Ligand (1), being a self-complementary unit, forms an infinite halogen-bonded chain driven by the S...I synthon, while the cocrystal (1)·(2) self-assembles into a discrete trimeric entity driven by the N...
April 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/28277669/control-of-primary-particle-spacing-in-gold-nanoparticle-clusters-for-both-high-nir-extinction-and-full-reversibility
#11
Ehsan Moaseri, Robert J Stover, Behzad Changalvaie, Alexis J Cepeda, Thomas M Truskett, Konstantin V Sokolov, Keith P Johnston
Reversible NIR-active nanoparticle clusters with controlled size from 20 to 100 nm were assembled from 5 nm gold nanoparticles (Au NP), with either citrate (CIT) or various binary ligands on the surface, by tuning the electrostatic repulsion and the hydrogen bonding via pH. The nanoclusters were bound together by vdW forces between the cores and the hydrogen bonds between the surface ligands and dissociated to primary nanoparticles over a period of 20 days at pH 5 and at pH 7. When high levels of citrate ligands were used on the primary particle surfaces, the large particle spacings in the nanoclusters led to only modest NIR extinction...
April 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28191471/lipids-a-suitable-therapeutic-target-in-diabetic-neuropathy
#12
REVIEW
M C Perez-Matos, M C Morales-Alvarez, C O Mendivil
Diabetic polyneuropathy (DPN) encompasses multiple syndromes with a common pathogenesis. Glycemic control shows a limited correlation with DPN, arguing in favor of major involvement of other factors, one of which is alterations of lipid and lipoprotein metabolism. Consistent associations have been found between plasma triglycerides/remnant lipoproteins and the risk of DPN. Studies in cultured nerve tissue or in murine models of diabetes have unveiled mechanisms linking lipid metabolism to DPN. Deficient insulin action increases fatty acids flux to nerve cells, inducing mitochondrial dysfunction, anomalous protein kinase C signaling, and perturbations in the physicochemical properties of the plasma membrane...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26990224/blockade-of-androgen-markers-using-a-novel-betasitosterol-thioctic-acid-and-carnitine-containing-compound-in-prostate-and-hair-follicle-cell-based-assays
#13
Li Chen, Jiaolong Wang, Glen Mouser, Yan Chun Li, Geno Marcovici
Androgenetic alopecia (AGA) affects approximately 70% of men and 40% of women in an age-dependent manner and is partially mediated by androgen hormones. Benign prostatic hyperplasia (BPH) similarly affects 50% of the male population, rising by 10% each decade. Finasteride inhibits 5-alpha reductase (5AR) and is used to treat both disorders, despite offering limited clinical benefits accompanied by significant adverse side effects. Building on our previous work demonstrating the efficacy of naturally derived 5AR inhibitors (such as stigmasterol and beta sitosterol), we hypothesize that targeting 5AR as well as inflammatory pathways may yield improved efficacy in AGA and BPH...
June 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26900409/bio-conjugation-of-antioxidant-peptide-on-surface-modified-gold-nanoparticles-a-novel-approach-to-enhance-the-radical-scavenging-property-in-cancer-cell
#14
Sushma Kalmodia, Suryanarayanan Vandhana, B R Tejaswini Rama, Balasubramanyam Jayashree, T Sreenivasan Seethalakshmi, Vetrivel Umashankar, Wenrong Yang, Colin J Barrow, Subramanian Krishnakumar, Sailaja V Elchuri
BACKGROUND: Functionalized gold nanoparticles are emerging as a promising nanocarrier for target specific delivery of the therapeutic molecules in a cancer cell, as a result it targeted selectively to the cancer cell and minimized the off-target effect. The functionalized nanomaterial (bio conjugate) brings novel functional properties, for example, the high payload of anticancer, antioxidant molecules and selective targeting of the cancer molecular markers. The current study reported the synthesis of multifunctional bioconjugate (GNPs-Pep-A) to target the cancer cell...
2016: Cancer Nanotechnology
https://www.readbyqxmd.com/read/26899808/further-evidence-of-thioctic-acid-%C3%AE-lipoic-acid-being-a-strong-cosmetic-sensitizer
#15
Julie Leysen, Olivier Aerts
No abstract text is available yet for this article.
March 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/26683093/controlled-multi-functionalization-facilitates-targeted-delivery-of-nanoparticles-to-cancer-cells
#16
Manish S Hudlikar, Xiuru Li, Ivan A Gagarinov, Nagesh Kolishetti, Margreet A Wolfert, Geert-Jan Boons
A major objective of nanomedicine is to combine in a controlled manner multiple functional entities into a single nanoscale device to target particles with great spatial precision, thereby increasing the selectivity and potency of therapeutic drugs. A multifunctional nanoparticle is described for controlled conjugation of a cytotoxic drug, a cancer cell targeting ligand, and an imaging moiety. The approach is based on the chemical synthesis of polyethylene glycol that at one end is modified by a thioctic acid for controlled attachment to a gold core...
January 22, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/26358837/extremely-high-efficient-nanoreactor-with-au-zno-catalyst-for-photocatalysis
#17
Chung-Yi Su, Tung-Han Yang, Vitaly Gurylev, Sheng-Hsin Huang, Jenn-Ming Wu, Tsong-Pyng Perng
We fabricated a photocatalytic Au@ZnO@PC (polycarbonate) nanoreactor composed of monolayered Au nanoparticles chemisorbed on conformal ZnO nanochannel arrays within the PC membrane. A commercial PC membrane was used as the template for deposition of a ZnO shell into the pores by atomic layer deposition (ALD). Thioctic acid (TA) with sufficient steric stabilization was used as a molecular linker for functionalization of Au nanoparticles in a diameter of 10 nm. High coverage of Au nanoparticles anchored on the inner wall of ZnO nanochannels greatly improved the photocatalytic activity for degradation of Rhodamine B...
October 2, 2015: Nanotechnology
https://www.readbyqxmd.com/read/26303592/a-self-reporting-tetrazole-based-linker-for-the-biofunctionalization-of-gold-nanorods
#18
Lukas Stolzer, Antonina Vigovskaya, Christopher Barner-Kowollik, Ljiljana Fruk
A photochemical approach based on nitrile imine-mediated tetrazole-ene cycloaddition is introduced to functionalize gold nanorods with biomolecules. For this purpose, a bifunctional, photoreactive linker containing thioctic acid as the Au anchoring group and a tetrazole moiety for the light-induced reaction with maleimide-capped DNA was prepared. The tetrazole-based reaction on the nanoparticles' surface results in a fluorescent pyrazoline product allowing for the spectroscopic monitoring of the reaction. This first example of nitrile imine-mediated tetrazole-ene cycloaddition (NITEC)-mediated biofunctionalization of Au nanorods paves the way for the attachment of sensitive biomolecules, such as antibodies and other proteins, under mild conditions and expands the toolbox for the tailoring of nanomaterials...
October 5, 2015: Chemistry: a European Journal
https://www.readbyqxmd.com/read/26235578/effect-of-piperazine-dithioctate-on-the-oral-pharmacokinetics-of-glimepiride-in-rats
#19
Eun-Yeong Kim, Keewon Yu, Kyungmi Choi, Hyung Eun Yu, Soo Jin Oh, Kiho Lee
The objective of the present work was to investigate the potential for pharmacokinetic drug-drug interactions between glimepiride (GMP) and piperazine dithioctate (PDT) in rats to support the development of an orally combined product of the two drugs. An LC-MS/MS bioanalytical method was developed for simultaneous quantification of GMP and thioctic acid (TA) in rat plasma. The accuracy, precision, linearity, selectivity, and recovery were all within an acceptable range. The oral plasma exposure of the GMP solution was more than 14-times greater than that of the GMP suspension at a dose of 0...
2015: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/26207883/effect-of-treatment-with-the-antioxidant-alpha-lipoic-thioctic-acid-on-heart-and-kidney-microvasculature-in-spontaneously-hypertensive-rats
#20
Seyed Khosrow Tayebati, Daniele Tomassoni, Lorenzo Di Cesare Mannelli, Francesco Amenta
Endothelial cells represent an important vascular site of signaling and development of damage during ischemia, inflammation and other pathological conditions. Excessive reactive oxygen species production causes pathological activation of endothelium including exposure of cell to adhesion molecules. Intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) are members of the immunoglobulin super-family which are present on the surface of endothelial cells...
2016: Clinical and Experimental Hypertension: CHE
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