Simone Baldi, Alessio Fabbrizzi, Leandro Di Gloria, Marco Pallecchi, Giulia Nannini, Mario D'Ambrosio, Cristina Luceri, Gianluca Bartolucci, Matteo Ramazzotti, Giovanni Fontana, Claudia Mannini, Federico Lavorini, Amedeo Amedei
PURPOSE: Cough represents a natural mechanism that plays an important defensive role in the respiratory tract, but in some conditions, it may become persistent, nonproductive, and harmful. In general, refractory chronic cough (RCC) occurs in about 20% of individuals; hence, we aimed to assess the presence of altered gut-lung communication in RCC patients through a compositional and functional characterization of both gut (GM) and oral microbiota (OM). METHODS: 16S rRNA sequencing was used to characterize both GM and OM composition of RCC patients and healthy controls (HC)...
March 25, 2024: Lung