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alpha lipoic acid

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https://www.readbyqxmd.com/read/29432779/the-protective-effect-of-alpha-lipoic-acid-against-brain-ischemia-and-reperfusion-injury-via-mtor-signaling-pathway-in-rats
#1
Xinjie Gao, Wei Chen, Jinquan Li, Chao Shen, Ping Zhou, Xiaoming Che, Xiaomu Li, Rong Xie
Alpha-lipoic Acid(ALA), an endogenous short-chain fatty acid, has been found inducing a protective effect against ischemia and reperfusion(I/R) injury. Recently, mTOR signaling pathway has been proved to involve in the mechanism of I/R injury. In our previous study, we determined that ALA could protect cerebral endothelial cells against I/R injury via mTOR signaling pathway. However, whether ALA can protect against brain I/R injury in vivo and its mechanisms is uncertain. In this study, we try to explore if the ALA treatment can protect against brain I/R injury and confirm the relationship between ALA and mTOR signaling pathway...
February 9, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29427700/new-arguments-for-beneficial-effects-of-alpha-lipoic-acid-on-the-cardiovascular-system-in-the-course-of-type-2-diabetes
#2
Marzena Dworacka, Galina Chukanova, Saule Iskakova, Yergen Kurmambayev, Anna Wesołowska, Bartosz A Frycz, Paweł P Jagodziński, Grzegorz Dworacki
PURPOSE: Alpha-lipoic acid (ALA), widely known as an antioxidant, modifies also serum levels of angiogenic factors in type 2 diabetic patients. These pharmacological activities may influence the status of the cardiovascular system. Taking into consideration that diabetes is related to the increased cardiovascular risk we investigated several effects of ALA on angiogenic factors in the myocardium and in the aortal wall using a rat model of type 2 diabetes. METHODS: Diabetes was induced in Wistar rats by a fat-rich diet and by intraperitoneal injection of a small dose of streptozotocin (30 mg/kg)...
February 7, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29427527/ubc-nepal-expedition-the-use-of-oral-antioxidants-does-not-alter-cerebrovascular-function-at-sea-level-or-high-altitude
#3
Alex B Hansen, Ryan L Hoiland, Nia C S Lewis, Michael M Tymko, Joshua C Tremblay, Michael Stembridge, Daniela Nowak-Flück, Howard H Carter, Damian M Bailey, Philip N Ainslie
Hypoxia is associated with an increased systemic and cerebral formation of free radicals and associated reactants that may be linked to impaired cerebral vascular function a neurological sequela. To what extent oral antioxidants prophylaxis impacts cerebrovascular function in humans throughout the course of acclimatization to the hypoxia of terrestrial high-altitude has not been examined. Thus, the purpose of the current study was to examine the influence of orally ingested antioxidants at clinically relevant doses (vitamin C, E, and alpha-lipoic acid) on cerebrovascular regulation at sea-level (344 m; n = 12; female n = 2 participants), and at high altitude (5050 m; n = 9; female n = 2), in a randomized, placebo-controlled, and double-blinded crossover design...
February 10, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29366000/effect-of-alpha-lipoic-acid-supplementation-on-oxidative-stress-markers-and-antioxidative-defense-in-patients-with-diabetic-neuropathy
#4
Ferenc Sztanek, Ildiko Seres, Hajnalka Lorincz, Agnes Molnar, Gyorgy Paragh
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29359643/impaired-thiol-disulphide-homeostasis-in-patients-with-axonal-polyneuropathy
#5
Gonul Vural, Hesna Bektas, Sadiye Gumusyayla, Orhan Deniz, Murat Alışık, Ozcan Erel
OBJECTIVE: The objective of this study is to examine thiol-disulphide homeostasis in patients with polyneuropathy dominated by diabetic or non-diabetic axonal degeneration. MATERIALS-METHODS: Fifty-four patients diagnosed with polyneuropathy dominated by axonal damage and 41 healthy subjects were included in the study. The patients were grouped into two groups according to whether or not they had diabetes. The native thiol and total thiol concentrations were measured with the newly developed automated method...
January 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29356576/effect-of-alpha-lipoic-acid-on-clinical-and-neurophysiologic-recovery-of-carpal-tunnel-syndrome-a-double-blind-randomized-clinical-trial
#6
Elisa Alejandra Monroy Guízar, Leonel García Benavides, Ana Rosa Ambriz Plascencia, Sara Pascoe González, Sylvia Elena Totsuka Sutto, Ernesto German Cardona Muñoz, Miriam Méndez-Del Villar
The objective of our study was to examine the effect of alpha-lipoic acid (ALA) on clinical and neurophysiologic outcomes after surgery for idiopathic carpal tunnel syndrome (CTS). We conducted a randomized, double-blind, placebo-controlled clinical trial in 20 adults diagnosed with idiopathic CTS after clinical and neurophysiologic assessment. Eligible participants took 600 mg ALA or placebo per day for 1 month before surgery, and for 2 months afterward. Further clinical and neurophysiologic assessments were undertaken immediately before surgical decompression, and at 12 weeks postoperatively with additional clinical assessments at the 4th and 8th week after surgery...
January 22, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29337238/advantages-of-the-alpha-lipoic-acid-association-with-chlorpromazine-in-a-model-of-schizophrenia-induced-by-ketamine-in-rats-behavioral-and-oxidative-stress-evidences
#7
Luis Rafael Leite Sampaio, Francisco Maurício Sales Cysne Filho, Jamily Cunha de Almeida, Danilo Dos Santos Diniz, Cláudio Felipe Vasconcelos Patrocínio, Caren Nádia Soares de Sousa, Manoel Cláudio Azevedo Patrocínio, Danielle S Macêdo, Silvânia Maria Mendes Vasconcelos
Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's population. Although its pathophysiological process is not completely elucidated, evidence showing the presence of an oxidative imbalance has been increasingly highlighted in the literature. Thus, the use of antioxidant substances may be of importance for schizophrenia treatment. The objective of this study was to evaluate the behavioral and oxidative alterations by the combination of chlorpromazine (CP) and alpha-lipoic acid (ALA), a potent antioxidant, in the ketamine (KET) model of schizophrenia in rats...
January 11, 2018: Neuroscience
https://www.readbyqxmd.com/read/29314036/multilayer-emulsions-as-a-strategy-for-linseed-oil-and-alpha-lipoic-acid-micro-encapsulation-study-on-preparation-and-in-vitro-characterization
#8
Juan Huang, Qiang Wang, Tong Li, Nan Xia, Qiang Xia
BACKGROUND: Linseed oil and alpha-lipoic acid are bioactive ingredients, which play an important role in human's nutrition and health. However, their application in functional foods is limited because of their instabilities and poor solubilities in hydrophilic matrices. Multilayer emulsions are particularly useful to protect encapsulated bioactive ingredients. The aim of this study was to fabricate multilayer emulsions by high pressure homogenization method to encapsulate linseed oil and alpha-lipoic acid simultaneously...
January 4, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29300330/alpha-lipoic-acid-a-therapeutic-strategy-that-tend-to-limit-the-action-of-free-radicals-in-transplantation
#9
REVIEW
Nella Ambrosi, Diego Guerrieri, Fiorella Caro, Francisco Sanchez, Geraldine Haeublein, Domingo Casadei, Claudio Incardona, Eduardo Chuluyan
Organ replacement is an option to mitigate irreversible organ damage. This procedure has achieved a considerable degree of acceptance. However, several factors significantly limit its effectiveness. Among them, the initial inflammatory graft reaction due to ischemia-reperfusion injury (IRI) has a fundamental influence on the short and long term organ function. The reactive oxygen species (ROS) produced during the IRI actively participates in these adverse events. Therapeutic strategies that tend to limit the action of free radicals could result in beneficial effects in transplantation outcome...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29249928/the-antioxidant-cofactor-alpha-lipoic-acid-may-control-endogenous-formaldehyde-metabolism-in-mammals
#10
Anastasia V Shindyapina, Tatiana V Komarova, Ekaterina V Sheshukova, Natalia M Ershova, Vadim N Tashlitsky, Alexander V Kurkin, Ildar R Yusupov, Garik V Mkrtchyan, Murat Y Shagidulin, Yuri L Dorokhov
The healthy human body contains small amounts of metabolic formaldehyde (FA) that mainly results from methanol oxidation by pectin methylesterase, which is active in a vegetable diet and in the gastrointestinal microbiome. With age, the ability to maintain a low level of FA decreases, which increases the risk of Alzheimer's disease and dementia. It has been shown that 1,2-dithiolane-3-pentanoic acid or alpha lipoic acid (ALA), a naturally occurring dithiol and antioxidant cofactor of mitochondrial α-ketoacid dehydrogenases, increases glutathione (GSH) content and FA metabolism by mitochondrial aldehyde dehydrogenase 2 (ALDH2) thus manifests a therapeutic potential beyond its antioxidant property...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29246754/thioctic-acid-in-oral-submucous-fibrosis-india-s-disease-a-better-tomorrow
#11
Bhandarkar Gowri Pandarinath, V Shetty Kushal, Kulkarni Arati
Oral submucous fibrosis(OSMF), because of its common occurrence in Indian population is known as India's disease. Regardless of diagnostic and therapeutic developments, oral potentially malignant disorders(PMD) and cancers are disseminating at a distressing rate. There is this prerequisite for unrelenting determination to find out apt treatment options so that malignant transformation may be prevented and more so the prevailing morbidity and mortality. Considering the frequency with which oral submucous fibrosis undergoes malignant transformation with free radicals playing a major part, the role of antioxidants in general and thioctic acid also known as alpha lipoic acid(ALA) in particular need to be studied in these individuals...
December 12, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29234485/regulation-of-sirtuin-mediated-protein-deacetylation-by-cardioprotective-phytochemicals
#12
REVIEW
Niria Treviño-Saldaña, Gerardo García-Rivas
Modulation of posttranslational modifications (PTMs), such as protein acetylation, is considered a novel therapeutic strategy to combat the development and progression of cardiovascular diseases. Protein hyperacetylation is associated with the development of numerous cardiovascular diseases, including atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. In addition, decreased expression and activity of the deacetylases Sirt1, Sirt3, and Sirt6 have been linked to the development and progression of cardiac dysfunction...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29233029/molecular-hepatoprotective-effects-of-lipoic-acid-against-carbon-tetrachloride-induced-liver-fibrosis-in-rats-hepatoprotection-at-molecular-level
#13
K M Sadek, E A Saleh, S M Nasr
BACKGROUND: Liver fibrosis is a noteworthy well-being issue that can prompt the progression of liver cirrhosis and hepatocellular carcinoma. Prominently, many antioxidants have been shown to have defensive impacts against liver fibrosis. AIM: Subsequently, in the present study, the viability of alpha-lipoic acid (α-LA) in ensuring against carbon tetrachloride (CCl4)-actuated liver fibrosis and the mechanism(s) involved in this defensive impact were considered in rats...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29191830/lipoic-acid-metabolism-and-mitochondrial-redox-regulation
#14
Ashley D Solmonson, Ralph J DeBerardinis
Lipoic acid is an essential cofactor for mitochondrial metabolism and is synthesized de novo using intermediates from mitochondrial fatty acid synthesis type II, S-adenosylmethionine and iron-sulfur clusters. This cofactor is required for catalysis by multiple mitochondrial 2-ketoacid dehydrogenase complexes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and branched-chain ketoacid dehydrogenase. Lipoic acid also plays a critical role in stabilizing and regulating these multi-enzyme complexes...
November 30, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29159335/protective-effects-of-lipoic-acid-against-acrylamide-induced-neurotoxicity-involvement-of-mitochondrial-energy-metabolism-and-autophagy
#15
Ge Song, Zhigang Liu, Luanfeng Wang, Renjie Shi, Chuanqi Chu, Man Xiang, Qi Tian, Xuebo Liu
Acrylamide (ACR) is a chronic neurotoxin that is generated in high-starch foods during heat processing. Alpha-lipoic acid (LA) is an antioxidant that occurs in most plants and animals. The objective of this study was to reveal the mechanism of ACR-triggered neurotoxicity and identify the protective role of LA in SH-SY5Y cells. In this study, LA restored ACR-stimulated depletion of glutathione content and mitochondrial membrane potential, moderated the activation of inflammatory pathways, and recovered the Keap1/Nrf2 pathway...
November 21, 2017: Food & Function
https://www.readbyqxmd.com/read/29140431/microvascular-adaptations-to-exercise-protective-effect-of-pgc-1-alpha
#16
Andrew O Kadlec, Chad Barnes, Matthew J Durand, David D Gutterman
BACKGROUND: Sedentary behavior and obesity are major risk factors for cardiovascular disease. Regular physical activity has independent protective effects on the cardiovascular system, but the mechanisms responsible remain elusive. Recent studies suggest that the protein peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) participates in the response to exercise training. We hypothesized that the arterioles of athletes maintain dilation to flow despite combined inhibition of multiple vasodilators, but loss of PGC-1α renders these vessels susceptible to inhibition of a single vasodilator pathway...
November 11, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29100334/paradoxical-effects-of-137-cs-irradiation-on-pharmacological-stimulation-of-reactive-oxygen-species-in-hippocampal-slices-from-apoe2-and-apoe4-mice
#17
Laura E Villasana, Tunde Akinyeke, Sydney Weber, Jacob Raber
In humans, apoE, which plays a role in repair, is expressed in three isoforms: E2, E3, and E4. E4 is a risk factor for age-related cognitive decline (ACD) and Alzheimer's disease (AD), particularly in women. In contrast, E2 is a protective factor for ACD and AD. E2 and E4 might also differ in their response to cranial (137)Cs irradiation, a form of radiation typically used in a clinical setting for the treatment of cancer. This might be mediated by reactive oxygen species (ROS) in an-apoE isoform-dependent fashion...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098625/c-ebpb-cited4-in-exercised-heart
#18
Shengguang Ding, Tianyi Gan, Meiyi Song, Qiying Dai, Haitao Huang, Yiming Xu, Chongjun Zhong
C/EBPB is a crucial transcription factor, participating in a variety of biological processes including cell proliferation, differentiation and development. In the cardiovascular system, C/EBPB-CITED4 signaling is known as a signaling pathway mediating exercise-induced cardiac growth. After its exact role in exercised heart firstly reported in 2010, more and more evidence confirmed that. MicroRNA (e.g. miR-222) and many molecules (e.g. Alpha-lipoic acid) can regulate this pathway and then involve in the cardiac protection effect induced by endurance exercise training...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29090431/modulatory-effects-of-alpha-lipoic-acid-ala-administration-on-insulin-sensitivity-in-obese-pcos-patients
#19
A D Genazzani, K Shefer, D Della Casa, A Prati, A Napolitano, A Manzo, G Despini, T Simoncini
PURPOSE: To evaluate the efficacy of alpha-lipoic acid (ALA) administration on hormonal and metabolic parameters of obese PCOS patients. METHODS: A group of 32 obese PCOS patients were selected after informed consent. 20 patients referred to have first grade relatives with diabetes type I or II. Hormonal and metabolic parameters as well as OGTT were evaluated before and after 12 weeks of ALA integrative administration (400 mg per os every day). RESULTS: ALA administration significantly decreased insulin, glucose, BMI and HOMA index...
October 31, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29077914/effects-of-dietary-vitamin-c-vitamin-e-and-alpha-lipoic-acid-supplementation-on-the-antioxidant-defense-system-and-immune-related-gene-expression-in-broilers-exposed-to-oxidative-stress-by-dexamethasone
#20
H K El-Senousey, B Chen, J Y Wang, A M Atta, F R Mohamed, Q H Nie
Vitamin C, vitamin E, and alpha-lipoic acid (ALA) are potent nutritional antioxidants, which are important for enhancing immunity. This study compared the effects of supplementation with vitamin C, vitamin E, or ALA on the antioxidant defense system and the expression of immune-related genes under oxidative stress induced by dexamethasone (DEX) in broilers. In total, 240 one-day-old female Recessive White Rock chickens were assigned randomly to either a basal diet (control group) or basal diet supplemented with vitamin C (200 mg/kg diet), vitamin E (100 mg/kg), or ALA (500 mg/kg) for 28 d starting from hatching...
October 25, 2017: Poultry Science
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