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https://www.readbyqxmd.com/read/29334126/methylated-pacs-are-more-potent-than-their-parent-compounds-a-study-on-ahr-mediated-activity-degradability-and-mixture-interactions-in-the-h4iie-luc-assay
#1
Monika M Lam, Rebecca Bülow, Magnus Engwall, John P Giesy, Maria Larsson
In this study, 26 polycyclic aromatic compounds (PACs) including native polycyclic aromatic hydrocarbons (PAHs), hydroxylated PAHs, alkylated and oxygenated PAHs and (alkylated) heterocyclic compounds were investigated for their aryl hydrocarbon receptor (AhR)-mediated potencies in the H4IIE-luc bioassay. Potential degradabilities of PACs were investigated by use of various durations of exposure (24, 48 or 72 h). Furthermore, various mixtures of PACs including PAHs, alkylated and oxygenated PAHs and heterocyclic compounds were tested for their joint AhR-mediated potency...
January 15, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29331224/centrifugal-partition-chromatography-enables-selective-enrichment-of-trimeric-and-tetrameric-proanthocyanidins-for-biomaterial-development
#2
Rasika S Phansalkar, Joo-Won Nam, Shao-Nong Chen, James B McAlpine, Ariene A Leme, Berdan Aydin, Ana-Karina Bedran-Russo, Guido F Pauli
Proanthocyanidins (PACs) find wide applications for human use including food, cosmetics, dietary supplements, and pharmaceuticals. The chemical complexity associated with PACs has triggered the development of various chromatographic techniques, with countercurrent separation (CCS) gaining in popularity. This study applied the recently developed DESIGNER (Depletion and Enrichment of Select Ingredients Generating Normalized Extract Resources) approach for the selective enrichment of trimeric and tetrameric PACs using centrifugal partition chromatography (CPC)...
December 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29330668/impact-of-duplicate-ct-scan-rate-after-implementation-of-transfer-image-repository-system-at-a-level-1-trauma-center
#3
Charles W Sheppard, Amy L Groll, Cindy L Austin, Simon J Thompson
PURPOSE: The regionalization of trauma in the USA results in frequent transfers of patients from a primary hospital ED to a higher level trauma facility. While many hospitals have a Picture Archive Communication System (PACS) which captures digital radiological images, these are often not available to the receiving institution resulting in duplicate imaging. The state of Arkansas instituted a trauma image repository (TIR) in July 2013. We examined whether implementation of this repository would impact CT scan duplication in the trauma system...
January 12, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29327154/effect-of-synthesis-method-of-la1%C3%A2-%C3%A2-xsr-x-mno3-manganite-nanoparticles-on-their-properties
#4
Yulia Shlapa, Sergii Solopan, Anatolii Belous, Alexandr Tovstolytkin
Nanoparticles of lanthanum-strontium manganite were synthesized via different methods, namely, sol-gel method, precipitation from non-aqueous solution, and precipitation from reversal microemulsions. It was shown that the use of organic compounds and non-aqueous media allowed significantly decreasing of the crystallization temperature of nanoparticles, and the single-phased crystalline product was formed in one stage. Morphology and properties of nanoparticles depended on the method and conditions of the synthesis...
January 11, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29325748/cranberry-proanthocyanidin-chitosan-hybrid-nanoparticles-as-a-potential-inhibitor-of-extra-intestinal-pathogenic-escherichia-coli-invasion-of-gut-epithelial-cells
#5
Emilia Alfaro-Viquez, Daniel Esquivel-Alvarado, Sergio Madrigal-Carballo, Christian G Krueger, Jess D Reed
Chitosan interacts with proanthocyanidins through hydrogen-bonding, which allows encapsulation and development of stable nanoparticles via ionotropic gelation. Cranberry proanthocyanidins (PAC) are associated with the prevention of urinary tract infections and PAC inhibit invasion of gut epithelial cells by extra-intestinal pathogenic Escherichia coli (ExPEC). We determined the effect of cranberry proanthocyanidin-chitosan hybrid nanoparticles (PAC-CHTNp) on the ExPEC invasion of gut epithelial cells in vitro...
January 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29321991/buddleja-globosa-matico-prevents-collagen-induced-platelet-activation-by-decreasing-phospholipase-c-gamma-2-and-protein-kinase-c-phosphorylation-signaling
#6
Manuel Fuentes, Cesar Sepúlveda, Marcelo Alarcón, Iván Palomo, Eduardo Fuentes
Platelets play a key role in thrombosis and cardiovascular diseases. Medicinal plants could be one of the most important factors that influence risks for platelet activation. Buddleja globosa (known as "matico") is a medicinal plant with many biological activities. The high content of polyphenols suggest that matico could have antiplatelet activity. The present study was aimed at evaluating mechanisms of antiplatelet action of an extract of matico. We demonstrated that matico extract at low concentrations and in a concentration dependent manner (0...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321951/utility-of-the-phenacyl-protecting-group-in-traceless-protein-semisynthesis-through-ligation-desulfurization-chemistry
#7
Maria Matveenko, Stefanie Hackl, Christian F W Becker
Semisynthesis of proteins via expressed protein ligation is a widely applicable method, even more so because of the possibility of ligation at non-cysteine sites using β-mercapto amino acids that can be converted to the corresponding native amino acids by desulfurization. A drawback of this ligation- desulfurization approach is the removal of any unprotected native cysteine residues within the ligated protein segments. Here, we show that the phenacyl (PAc) moiety can be successfully used to protect cysteines within recombinantly generated protein segments...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29321218/non-uniform-relationship-between-salt-status-and-aldosterone-activity-in-patients-with-chronic-kidney-disease
#8
Alison H M Taylor, Alastair J Rankin, Emily P McQuarrie, E Marie Freel, Natalie Z M Homer, Ruth Andrew, Alan G Jardine, Patrick B Mark
BACKGROUND: Hypertension is prevalent in chronic kidney disease (CKD). Studies suggest that reduction in dietary salt intake reduces blood pressure (BP). We studied relationships between salt intake, BP and renin angiotensin system regulation in order to establish if it is disordered in CKD. METHODS: Mechanistic crossover study of CKD patients versus non-CKD controls. Participants underwent modified saline suppression test prior to randomisation to either low or high salt diet for 5 days and then crossed over to the alternate diet...
January 10, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29321009/dual-action-of-highbush-blueberry-proanthocyanidins-on-aggregatibacter-actinomycetemcomitans-and-the-host-inflammatory-response
#9
Amel Ben Lagha, Geneviève LeBel, Daniel Grenier
BACKGROUND: The highbush blueberry (Vaccinium corymbosum) has a beneficial effect on several aspects of human health. The present study investigated the effects of highbush blueberry proanthocyanidins (PACs) on the virulence properties of Aggregatibacter actinomycetemcomitans and macrophage-associated inflammatory responses. METHODS: PACs were isolated from frozen highbush blueberries using solid-phase chromatography. A microplate dilution assay was performed to determine the effect of highbush blueberry PACs on A...
January 10, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29318512/health-status-of-older-cancer-survivors-results-of-the-polsenior-study
#10
Joanna Sulicka, Agnieszka Pac, Monika Puzianowska-Kuźnicka, Tomasz Zdrojewski, Jerzy Chudek, Beata Tobiasz-Adamczyk, Małgorzata Mossakowska, Anna Skalska, Andrzej Więcek, Tomasz Grodzicki
PURPOSE: The purpose of this study is to characterize health status of older cancer survivors using data from the population-based PolSenior study. METHODS: We compared cancer survivors and non-cancer subjects according to comorbidities, functional status, mental health, and sociodemographic factors. RESULTS: There were 286 (5.8%) cancer survivors in a population of 4943 adults aged 65 years and older. The mean age of cancer survivors was 79...
January 9, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29318487/dpf-soot-as-an-adsorbent-for-cu-ii-cd-ii-and-cr-vi-compared-with-commercial-activated-carbon
#11
Kun Yang, John Fox
The use of carbon soot recovered from diesel particulate filters (DPF) has been investigated as a potential adsorbent for heavy metals including cadmium, chromium, and copper from wastewater. Results were compared with the adsorption performance of powder activated carbon (PAC). The uptake capacity of heavy metals for soot was found to be higher than PAC. And the thermodynamic study result for both soot and PAC indicated the adsorption procedures are exothermic. The adsorption studies were carried out for both single and binary systems...
January 9, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29317186/perturbation-of-theta-gamma-coupling-at-the-temporal-lobe-hinders-verbal-declarative-memory
#12
Gabriel Amador de Lara, Ivan Alekseichuk, Zsolt Turi, Albert Lehr, Andrea Antal, Walter Paulus
BACKGROUND: Phase-amplitude cross-frequency coupling (PAC) is characterized by the modulation of the power of a fast brain oscillation (e.g., gamma) by the phase of a slow rhythm (e.g., theta). PAC in different sub- and neocortical regions is known to underlie effective neural communication and correlates with successful long-term memory formation. OBJECTIVE/HYPOTHESIS: The present work aims to extend earlier observational data, by probing the functional role of theta-gamma PAC in the left temporal cortex in humans during verbal long-term memory encoding...
December 25, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29315665/effect-of-remote-ischemic-preconditioning-on-left-atrial-remodeling-and-prothrombotic-response-after-radiofrequency-catheter-ablation-for-atrial-fibrillation
#13
Ruijuan Han, Xiaoqing Liu, Meili Zheng, RuiPing Zhao, XiaoYan Liu, Xiandong Yin, Xingpeng Liu, Ying Tian, Liang Shi, Kai Sun, Xinchun Yang
BACKGROUND: Radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) is known to induce left atrial remodeling and prothrombotic response. AIMS: This study aimed to evaluate the effect of remote ischemic preconditioning (RIPC) on left atrial remodeling and prothrombotic response induced by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF). METHODS: Forty-four patients with drug-refractory paroxysmal AF undergoing RFCA were randomized into RIPC (4 short episodes of forearm ischemia) and control groups before the procedure...
January 5, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29312549/the-akt-inhibitor-triciribine-in-combination-with-paclitaxel-has-order-specific-efficacy-against-zfp217-induced-breast-cancer-chemoresistance
#14
Christopher D Suarez, Junmin Wu, Sunil S Badve, Joseph A Sparano, William Kaliney, Laurie E Littlepage
We previously identified the transcription factor ZNF217 (human) / Zfp217 (mouse) as an oncogene and prognostic indicator of reduced survival, increased metastasis, and reduced response to therapy in breast cancer patients. Here we investigated the role of Zfp217 in chemotherapy resistance. Preclinical animal models of Zfp217 overexpression were treated with a combination therapy of the microtubule inhibitor epothilone B, doxorubicin (Adriamycin), and cyclophosphamide (EAC). Tumors overexpressing Zfp217 increased their tumor burden compared to control tumors after treatment and accumulated a mammary gland progenitor cell population (K8+K14+)...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29312533/loss-of-pacs-2-delays-regeneration-in-dss-induced-colitis-but-does-not-affect-the-apcmin-model-of-colorectal-cancer
#15
Sarah L Dombernowsky, Jeanette Schwarz, Jacob Samsøe-Petersen, Reidar Albrechtsen, Kim B Jensen, Gary Thomas, Marie Kveiborg
PACS-2 is a multifunctional sorting protein that mediates cell homeostasis. We recently identified PACS-2 in a functional genome-wide siRNA screen for novel regulators of the metalloproteinase ADAM17, the main sheddase for ligands of the ErbB receptor family. Of note, we showed that Pacs2-/- mice have significantly reduced EGFR activity and proliferative index in the intestinal epithelium. As EGFR signaling is highly mitogenic for intestinal epithelial stem cells, and plays essential roles in intestinal epithelial regeneration and tumor development, we have now examined the role of PACS-2 in these processes...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310965/evaluation-of-primary-angle-closure-glaucoma-susceptibility-loci-in-patients-with-early-stages-of-angle-closure-disease
#16
Monisha E Nongpiur, Ching-Yu Cheng, Roopam Duvesh, Saravanan Vijayan, Mani Baskaran, Chiea-Chuen Khor, John Allen, Srinivasan Kavitha, Rengaraj Venkatesh, David Goh, Rahat Husain, Pui Yi Boey, Desmond Quek, Ching Lin Ho, Tina T Wong, Shamira Perera, Tien Yin Wong, Subbiah R Krishnadas, Periasamy Sundaresan, Tin Aung, Eranga N Vithana
PURPOSE: To investigate whether newly identified genetic loci for primary angle-closure glaucoma (PACG) are associated with early stage angle-closure disease defined as primary angle closure suspect (PACS). DESIGN: Case-control study. PARTICIPANTS: A total of 1397 PACS patients and 943 controls of Chinese ethnicity from Singapore and 604 PACS patients and 287 controls of Indian ethnicity. METHODS: The 8 PACG single nucleotide polymorphisms (SNPs; rs11024102 at PLEKHA7, rs3753841 at COL11A1, rs1015213 located between PCMTD1 and ST18 son chromosome 8q, rs3816415 at EPDR1, rs1258267 at CHAT, rs736893 at GLIS3, rs7494379 at FERMT2, and rs3739821 mapping in between DPM2 and FAM102A) were genotyped by Taqman assays...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29307579/scarless-genome-editing-of-human-pluripotent-stem-cells-via-transient-puromycin-selection
#17
Benjamin Steyer, Qian Bu, Evan Cory, Keer Jiang, Stella Duong, Divya Sinha, Stephanie Steltzer, David Gamm, Qiang Chang, Krishanu Saha
Genome-edited human pluripotent stem cells (hPSCs) have broad applications in disease modeling, drug discovery, and regenerative medicine. We present and characterize a robust method for rapid, scarless introduction or correction of disease-associated variants in hPSCs using CRISPR/Cas9. Utilizing non-integrated plasmid vectors that express a puromycin N-acetyl-transferase (PAC) gene, whose expression and translation is linked to that of Cas9, we transiently select for cells based on their early levels of Cas9 protein...
January 3, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29306729/adding-to-the-complexity-of-fetal-and-neonatal-alloimmune-thrombocytopenia-reduced-fibrinogen-binding-in-the-presence-of-anti-hpa-1a-antibody-and-hypo-responsive-neonatal-platelets
#18
E Refsum, S Meinke, G Gryfelt, A Wikman, P Höglund
BACKGROUND: In fetal and neonatal alloimmune thrombocytopenia (FNAIT), maternal alloantibodies directed against paternally-derived platelet antigens are transported across the placenta to the fetus, where they may cause thrombocytopenia. The most serious complication of FNAIT is an intracranial hemorrhage (ICH), which may cause death or life-long disability of the child. Apart from alloantibody-mediated platelet destruction, the clinical outcome in FNAIT may be affected by properties of neonatal platelets and possible functional effects on platelets caused by maternal alloantibodies...
December 29, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29303875/outcome-following-laser-peripheral-iridotomy-and-predictors-of-future-lens-extraction
#19
Jenny Bo, Tulsi Changulani, Mei-Ling Cheng, Andrew J Tatham
PURPOSE: To examine the outcome of laser peripheral iridotomy (LPI) for primary angle closure (PAC) and determine predictors of future lens extraction (LE). METHODS: A retrospective chart review of 218 eyes from 128 consecutive patients undergoing LPI between 2010 and 2012 at a university hospital. Baseline factors including age, peak intraocular pressure (IOP) prior to LPI, diagnosis (primary angle closure suspect (PACS), PAC, primary angle closure glaucoma (PACG), and acute or non-acute presentation were recorded...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303395/acute-primary-angle-closure-after-periorbital-facial-procedures-report-of-four-cases-and-literature-review
#20
Mohsen Bahmani Kashkouli, Maria Sharepour, Hamed Sianati, Parya Abdolalizadeh
AIMS: To report four cases of acute primary angle closure (PAC) after blepharoplasty and forehead lifting procedures and review the previous reported cases in the literature. METHODS: Four female subjects with age range of 50-67 years developed PAC 2-5 days after blepharoplasty and endoscopic forehead lifting procedures. All presented with pain, nausea, blurred vision, red eye, and eyelid swelling. Diagnosis was delayed in the first subject because of considering the signs and symptoms as usual postoperative ones...
January 5, 2018: Orbit
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