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https://www.readbyqxmd.com/read/28932541/multimodality-treatment-of-stage-ii-thymic-tumours
#1
Carolina Carillo, Daniele Diso, Sara Mantovani, Ylenia Pecoraro, Tiziano De Giacomo, Anna Maria Ciccone, Camilla Poggi, Flavia Longo, Raffaele Cassese, Vincenzo Tombolini, Erino Angelo Rendina, Federico Venuta, Marco Anile
BACKGROUND: Complete resection for stage II thymic tumors can be easily accomplished even if the capsula and adjacent mediastinal tissue are macroscopically involved; however, also at this stage, recurrence may occur, particularly for B2, B3 and thymic carcinoma. The criteria for the administration of adjuvant therapy remain controversial and it is unclear whether patients at this stage may benefit from it. We reviewed a series of patients at this stage receiving adjuvant chemo-radiotherapy (chemo-RT) based on histology...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28930925/conical-modification-of-forearm-free-flaps-for-single-stage-reconstruction-after-total-orbital-exenteration
#2
Chad A Purnell, Elbert E Vaca, Marco F Ellis
BACKGROUND: Orbital exenteration is a significant reconstructive challenge for plastic surgeons. Options described for these defects range from healing by secondary intention to free tissue transfer. The authors present our preferred reconstruction of orbital defects with free forearm-based flaps, which provides quality soft tissue and orbital contouring in 1 stage to consistently allow placement of bone-anchored implants for eventual orbital prosthesis. METHODS: This conical shape of the orbit is deconstructed into a "Pac-Man" type shaped flap that leaves adequate depth for a prosthesis...
September 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28929806/clustered-microcysts-on-breast-ultrasound-what-is-an-appropriate-management-recommendation
#3
Heather I Greenwood, Amie Y Lee, Iryna V Lobach, Bianca M Carpentier, Rita I Freimanis, Loretta M Strachowski
OBJECTIVE: The objective of our study was to determine outcomes of lesions identified as clustered microcysts on breast ultrasound to augment the existing literature and help guide appropriate management recommendations. MATERIALS AND METHODS: We retrospectively identified cases at our institution, from January 2003 through December 2013, of all lesions classified as clustered microcysts at breast ultrasound. Breast ultrasound examinations were performed by the interpreting physician...
September 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28925750/study-of-the-x-ray-diagnosis-of-unstable-pelvic-fracture-displacements-in-three-dimensional-space-and-its-application-in-closed-reduction
#4
Chengdi Shi, Leyi Cai, Wei Hu, Junying Sun
ABSTRACTS Objective: To study the method of X-ray diagnosis of unstable pelvic fractures displaced in three-dimensional (3D) space and its clinical application in closed reduction. METHODS: Five models of hemipelvic displacement were made in an adult pelvic specimen. Anteroposterior radiographs of the pelvis were analyzed in PACS. The method of X-ray diagnosis was applied in closed reductions. From February 2012 to June 2016, 23 patients (15 men, 8 women; mean age, 43.4 years) with unstable pelvic fractures were included...
September 19, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28925252/the-binary-and-tertiary-complex-based-on-short-chain-glucan-and-proanthocyanidins-for-oral-insulin-delivery
#5
Na Ji, Yan Hong, Zhengbiao Gu, Li Cheng, Zhaofeng Li, Caiming Li
The present study was performed to investigate binary and tertiary nanocomposites between short-chain glucan (SCG) and proanthocyanidins (PAC) for the oral delivery of insulin. There was a large decrease in fluorescence intensity of insulin in the presence of SGC or the combination of SGC with PAC. Fourier transform infrared spectroscopy revealed that the binary and tertiary nanocomposites were synthesized due to the hydrogen bonding and hydrophobic interactions. The insulin entrapped in the nanocomposites was in an amorphous state confirmed by X-ray diffraction...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28924583/screening-for-primary-aldosteronism-using-the-newly-developed-ids-isys%C3%A2-automated-assay-system
#6
P M O'Shea, T P Griffin, G A Browne, N Gallagher, J J Brady, M C Dennedy, M Bell, D Wall, M Fitzgibbon
BACKGROUND: The recommended approach to screening for primary aldosteronism (PA) in at-risk populations is to determine the ratio of aldosterone concentration (serum (SAC)/plasma (PAC)) to renin measured in plasma as activity (PRA) or concentration (DRC). However, lack of assay standardisation mandates the need for method-specific decision thresholds and clinical validation in the local population. AIM: The study objective was to establish method-specific aldosterone: renin ratio (ARR) cut-offs for PA in men and women using the IDS-iSYS® assay system (IDS plc)...
April 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28920773/metronidazole-removal-in-powder-activated-carbon-and-concrete-containing-graphene-adsorption-systems-estimation-of-kinetic-equilibrium-and-thermodynamic-parameters-and-optimization-of-adsorption-by-a-central-composite-design
#7
S V Manjunath, S Mathava Kumar, Huu Hao Ngo, Wenshan Guo
Metronidazole (MNZ) removal by two adsorbents, i.e., concrete-containing graphene (CG) and powder-activated carbon (PAC), was investigated via batch-mode experiments and the outcomes were used to analyze the kinetics, equilibrium and thermodynamics of MNZ adsorption. MNZ sorption on CG and PAC has followed the pseudo-second-order kinetic model, and the thermodynamic parameters revealed that MNZ adsorption was spontaneous on PAC and non-spontaneous on CG. Subsequently, two-parameter isotherm models, i.e., Langmuir, Freundlich, Temkin, Dubinin-Radushkevich and Elovich models, were applied to evaluate the MNZ adsorption capacity...
September 18, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28919850/the-detection-of-phase-amplitude-coupling-during-sensory-processing
#8
Robert A Seymour, Gina Rippon, Klaus Kessler
There is increasing interest in understanding how the phase and amplitude of distinct neural oscillations might interact to support dynamic communication within the brain. In particular, previous work has demonstrated a coupling between the phase of low frequency oscillations and the amplitude (or power) of high frequency oscillations during certain tasks, termed phase amplitude coupling (PAC). For instance, during visual processing in humans, PAC has been reliably observed between ongoing alpha (8-13 Hz) and gamma-band (>40 Hz) activity...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28918094/post-acute-care-for-children-with-special-health-care-needs
#9
Charles D Phillips, Chau Truong, Hye-Chung Kum, Obioma Nwaiwu, Robert Ohsfeldt
BACKGROUND: Almost all studies of post-acute care (PAC) focus on older persons, frequently those suffering from chronic health problems. Some research is available on PAC for the pediatric population in general. However, very few studies focus on PAC services for children with special health care needs (SHCN). OBJECTIVE: To investigate factors affecting the provision of PAC to children with SHCN. METHODS: Pooled cross-sectional data from Texas Department of State Health Services hospital discharge database from 2011-2014 were analyzed...
September 8, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28903999/cdc42-regulates-junctional-actin-but-not-cell-polarization-in-the-caenorhabditis-elegans-epidermis
#10
Yuliya Zilberman, Joshua Abrams, Dorian C Anderson, Jeremy Nance
During morphogenesis, adherens junctions (AJs) remodel to allow changes in cell shape and position while preserving adhesion. Here, we examine the function of Rho guanosine triphosphatase CDC-42 in AJ formation and regulation during Caenorhabditis elegans embryo elongation, a process driven by asymmetric epidermal cell shape changes. cdc-42 mutant embryos arrest during elongation with epidermal ruptures. Unexpectedly, we find using time-lapse fluorescence imaging that cdc-42 is not required for epidermal cell polarization or junction assembly, but rather is needed for proper junctional actin regulation during elongation...
September 13, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28902496/photosensitization-behavior-of-ir-iii-complexes-in-selective-reduction-of-co2-by-re-i-complex-anchored-tio2-hybrid-catalyst
#11
Ha-Yeon Cheong, So-Yoen Kim, Yang-Jin Cho, Dae Won Cho, Chul Hoon Kim, Ho-Jin Son, Chyongjin Pac, Sang Ook Kang
A series of cationic Ir(III) complexes ([Ir(btp)2(bpy-X2)](+) (Ir-X(+): btp = (2-pyridyl)benzo[b]thiophen-3-yl; bpy-X2 = 4,4'-X2-2,2'-bipyridine (X = OMe, (t)Bu, Me, H, and CN)) were applied as visible-light photosensitizer to the CO2 reduction to CO using a hybrid catalyst (TiO2/ReP) prepared by anchoring of Re(4,4'-Y2-bpy)(CO)3Cl (ReP; Y = CH2PO(OH)2) on TiO2 particles. Irradiation of a solution containing Ir-X(+), TiO2/ReP particles, and an electron donor (1,3-dimethyl-2-phenyl-1,3-dihydrobenzimidazole) in N,N-dimethylformamide at greater than 400 nm resulted in the reduction of CO2 to CO with efficiencies in the order X = OMe > (t)Bu ≈ Me > H; Ir-CN(+) has no photosensitization effect...
September 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28901892/the-effect-of-anthocyanin-supplementation-in-modulating-platelet-function-in-sedentary-population-a-randomised-double-blind-placebo-controlled-cross-over-trial
#12
RANDOMIZED CONTROLLED TRIAL
Kiara Thompson, Holly Hosking, Wayne Pederick, Indu Singh, Abishek B Santhakumar
The anti-thrombotic properties of anthocyanin (ACN) supplementation was evaluated in this randomised, double-blind, placebo (PBO) controlled, cross-over design, dietary intervention trial in sedentary population. In all, sixteen participants (three males and thirteen females) consumed ACN (320 mg/d) or PBO capsules for 28 d followed by a 2-week wash-out period. Biomarkers of thrombogenesis and platelet activation induced by ADP; platelet aggregation induced by ADP, collagen and arachidonic acid; biochemical, lipid, inflammatory and coagulation profile were evaluated before and after supplementation...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28901011/persistent-aberrant-cortical-phase-amplitude-coupling-following-seizure-treatment-in-absence-epilepsy-models
#13
Atul Maheshwari, Abraham Akbar, Mai Wang, Rachel Marks, Katherine Yu, Suhyeorn Park, Brett L Foster, Jeffrey L Noebels
In childhood absence epilepsy, cortical seizures are brief and intermittent; however there are extended periods without behavioural or electrographic ictal events. This genetic disorder is associated with variable degrees of cognitive dysfunction, but no consistent functional biomarkers that might provide insight into interictal cortical function have been described. Previous work in monogenic mouse models of absence epilepsy have shown that the interictal EEG displays augmented beta/gamma power in homozygous stargazer (stg/stg) mice bearing a presynaptic AMPA receptor defect, but not homozygous tottering (tg/tg) mice with a P/Q type calcium channel mutation...
September 12, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28900790/medical-images-are-safe-an-enhanced-chaotic-scrambling-approach
#14
M Y Mohamed Parvees, J Abdul Samath, B Parameswaran Bose
The patient data confidentiality is one of the vital security aspects in e-Health and m-Health services. In particular, providing confidentiality to the patient's medical image is essential and the protection approaches have to be explored in-depth due to the rapid progress in the technologies of teleradiology and PACS. In this study, the pseudo random number generators (PRNGs), namely, the linear congruential generator (LCG) and XOR shift generator (XSG) are improved and combined with improved logistic 2D coupled chaotic map to provide enhanced chaos based encryption...
September 12, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28898194/correlate-a-pacs-and-ehr-integrated-tool-leveraging-natural-language-processing-to-provide-automated-clinical-follow-up
#15
Mark D Kovacs, Joseph Mesterhazy, David Avrin, Thomas Urbania, John Mongan
A major challenge for radiologists is obtaining meaningful clinical follow-up information for even a small percentage of cases encountered and dictated. Traditional methods, such as keeping medical record number follow-up lists, discussing cases with rounding clinical teams, and discussing cases at tumor boards, are effective at keeping radiologists informed of clinical outcomes but are time intensive and provide follow-up for a small subset of cases. To this end, the authors developed a picture archiving and communication system-accessible electronic health record (EHR)-integrated program called Correlate, which allows the user to easily enter free-text search queries regarding desired clinical follow-up information, with minimal interruption to the workflow...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28898128/technologist-directed-repeat-musculoskeletal-and-chest-radiographs-how-often-do-they-impact-diagnosis
#16
Andrew B Rosenkrantz, Jill E Jacobs, Nidhi Jain, Geraldine Brusca-Augello, Michael Mechlin, Marc Parente, Michael P Recht
OBJECTIVE: Radiologic technologists may repeat images within a radiographic examination because of perceived suboptimal image quality, excluding these original images from submission to a PACS. This study assesses the appropriateness of technologists' decisions to repeat musculoskeletal and chest radiographs as well as the utility of repeat radiographs in addressing examinations' clinical indication. MATERIALS AND METHODS: We included 95 musculoskeletal and 87 chest radiographic examinations in which the technologist repeated one or more images because of perceived image quality issues, rejecting original images from PACS submission...
September 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28894394/normative-values-for-colonic-transit-time-and-patient-assessment-of-constipation-in-adults-with-functional-constipation-systematic-review-with-meta-analysis
#17
REVIEW
Larry E Miller, Alvin Ibarra, Arthur C Ouwehand
Availability of normative patient outcome data may assist in designing experiments and estimating sample sizes. The purpose of this review was to determine normative ranges for colonic transit time (CTT), Patient Assessment of Constipation-Symptoms (PAC-SYM), and Patient Assessment of Constipation-Quality of Life (PAC-QOL) in adults diagnosed with functional constipation per Rome III guidelines. Pooled estimates were derived from random-effects meta-analysis. Meta-regression was used to explore sources of heterogeneity among studies...
2017: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/28893516/interleukin-6-is-independently-associated-with-right-ventricular-function-in-pulmonary-arterial-hypertension
#18
Kurt W Prins, Stephen L Archer, Marc Pritzker, Lauren Rose, E Kenneth Weir, Alok Sharma, Thenappan Thenappan
BACKGROUND: An elevated serum level of interleukin-6 (IL-6) in pulmonary arterial hypertension (PAH) patients results in a greater symptom burden and increased mortality; however, the mechanisms underlying these observations remain unclear. Because both pre-clinical and clinical data associate elevated IL-6 levels with impaired cardiac function, we hypothesized that the adverse effects of IL-6 in PAH result, in part, from right ventricular (RV) dysfunction. METHODS: We analyzed the relationship between IL-6 and RV function in 40 patients with PAH identified in our institutional PAH registry...
September 1, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28893430/excessive-atrial-ectopic-activity-as-an-independent-risk-factor-for-ischemic-stroke
#19
Rita Marinheiro, Leonor Parreira, Pedro Amador, Catarina Sá, Tatiana Duarte, Rui Caria
BACKGROUND: Excessive atrial ectopic activity (EAEA) has been related with an increased risk of atrial fibrillation (AF) and stroke but different cutoff values have been used. We aimed to determine the association between EAEA and stroke, AF and overall death. METHODS: Consecutive 24-hour Holter monitoring performed between 2005 and 2010 in a single center was evaluated. Patients with a previous diagnosis of stroke or AF were excluded. The number of premature atrial contractions (PACs) during 24h was analyzed in 2480 subjects and according to that 3 sub-groups were defined: >97PACs/h (above the top 5th percentile of the population) (EAEA+); intermediate value of PACs/h (below the top 5th percentile but above 30PACs/h) (EAEA+/-) and <30PACs/h (EAEA-)...
August 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28893411/suicidal-thoughts-in-persons-treated-for-alcohol-dependence-the-role-of-selected-demographic-and-clinical-factors
#20
Marcin Ziółkowski, Damian Czarnecki, Jan Chodkiewicz, Krzysztof Gąsior, Artur Juczyński, Agata Biedrzycka, Ewa Gruszczyńska, Katarzyna Nowakowska-Domagała
Greater knowledge is needed of potential predictive factors for suicide in cases of alcohol addiction. Therefore, the aim of the study was to identify the socio-demographic variables and clinical factors associated with alcohol dependence which may have an influence on the occurrence of suicidal thoughts in alcohol-dependent patients. A group of 510 patients (396 male and 114 female) diagnosed with alcohol dependence syndrome were interviewed during the third week of therapy according to the Beck Depression Inventory (BDI), the Penn Alcohol Craving Scale (PACS) and the Short Alcohol Dependence Data Questionnaire (SADD)...
September 1, 2017: Psychiatry Research
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