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https://www.readbyqxmd.com/read/29155448/influence-of-national-centralization-of-oesophagogastric-cancer-on-management-and-clinical-outcome-from-emergency-upper-gastrointestinal-conditions
#1
S R Markar, H Mackenzie, T Wiggins, A Askari, A Karthikesalingam, O Faiz, S M Griffin, J D Birkmeyer, G B Hanna
BACKGROUND: In England in 2001 oesophagogastric cancer surgery was centralized. The aim of this study was to evaluate whether centralization of oesophagogastric cancer to high-volume centres has had an effect on mortality from different emergency upper gastrointestinal conditions. METHODS: The Hospital Episode Statistics database was used to identify patients admitted to hospitals in England (1997-2012). The influence of oesophagogastric high-volume cancer centre status (20 or more resections per year) on 30- and 90-day mortality from oesophageal perforation, paraoesophageal hernia and perforated peptic ulcer was analysed...
November 20, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29154910/endoscopic-string-clip-suturing-method-a-prospective-pilot-study-with-video
#2
Toshihiro Nishizawa, Teppei Akimoto, Toshio Uraoka, Yutaka Mitsunaga, Tadateru Maehata, Yasutoshi Ochiai, Ai Fujimoto, Osamu Goto, Takanori Kanai, Naohisa Yahagi
BACKGROUND AND AIM: We developed a suturing method with string and clips for a single-channel endoscope. The feasibility of string clip suturing method was evaluated in this prospective pilot study. METHODS: This study involved consecutive 10 patients who underwent endoscopic submucosal dissection (ESD) for duodenal tumor. Polyester string is tied to the arm part of partially outthrusted clip. Clip and string can be passed through an instrument channel (3.2 mm) of a single-channel endoscope...
November 15, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29153975/optimisation-of-empirical-antimicrobial-therapy-in-patients-with-haematological-malignancies-and-febrile-neutropenia-how-long-study-an-open-label-randomised-controlled-phase-4-trial
#3
Manuela Aguilar-Guisado, Ildefonso Espigado, Almudena Martín-Peña, Carlota Gudiol, Cristina Royo-Cebrecos, José Falantes, Lourdes Vázquez-López, María Isabel Montero, Clara Rosso-Fernández, María de la Luz Martino, Rocío Parody, José González-Campos, Sebastián Garzón-López, Cristina Calderón-Cabrera, Pere Barba, Nancy Rodríguez, Montserrat Rovira, Enrique Montero-Mateos, Jordi Carratalá, José Antonio Pérez-Simón, José Miguel Cisneros
BACKGROUND: Continuation of empirical antimicrobial therapy (EAT) for febrile neutropenia in patients with haematological malignancies until neutrophil recovery could prolong the therapy unnecessarily. We aimed to establish whether EAT discontinuation driven by a clinical approach regardless of neutrophil recovery would optimise the duration of therapy. METHODS: We did an investigator-driven, superiority, open-label, randomised, controlled phase 4 clinical trial in six academic hospitals in Spain...
November 15, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29153632/a-2-to-16-year-clinical-follow-up-of-revision-total-hip-arthroplasty-using-a-new-acetabular-implant-combined-with-impacted-bone-allografts-and-a-cemented-cup
#4
Hampus Stigbrand, Oscar Gustafsson, Gösta Ullmark
BACKGROUND: Treatment of acetabular bone loss with impaction bone grafting (IBG) at revision total hip arthroplasty is highly dependent on mechanical stability and graft compression for clinical success. Here, we describe a new technique to further compress and stabilize the acetabular graft bed with a thin, perforated titanium shell. METHODS: We retrospectively analyzed 170 cases of acetabular revision arthroplasty 7 years (standard deviation 2.8) after IBG combined with a graft-compressing titanium shell implant...
October 10, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29152783/comparison-of-sub-versus-suprafascially-raised-anterolateral-thigh-free-flaps-with-regard-to-donor-site-morbidity-function-and-aesthetics
#5
Sebastian Fischer, Yannick Diehm, Christoph Hirche, Thomas Kremer, Adrien Daigeler, Ulrich Kneser, J Frederick Hernekamp
BACKGROUND: Although the anterolateral thigh flap (ALT) is one of the most frequently applied free flaps in plastic surgery, it remains controversial if the flap should be raised in a sub- or suprafascial plane. The purpose of this study was to compare both harvest techniques regarding donor-site morbidity and outcomes. METHODS: We included 40 pair-matched patients, of whom 20 received a fasciocutaneous and 20 an adipocutaneous ALT free flap for extremity reconstruction...
November 20, 2017: Microsurgery
https://www.readbyqxmd.com/read/29152421/severe-acute-respiratory-distress-syndrome-after-laparoscopic-appendectomy-in-a-young-adult
#6
Gabriel O Ologun, Daniel Ridley, Nhean D Chea, Daniel Golden, Anne Lihau-N'Kanza, Philip McPhail
Severe acute respiratory distress syndrome after laparoscopic appendectomy for acute appendicitis in a young adult is an uncommon complication. We describe the case of a 25-year-old male who developed severe acute respiratory distress syndrome after an uneventful laparoscopic appendectomy for a perforated appendix, requiring mechanical ventilation in the intensive care unit.
September 8, 2017: Curēus
https://www.readbyqxmd.com/read/29151482/radiation-induced-coronary-artery-disease-manifested-at-very-late-phase
#7
Shu Inami, Shichiro Abe, Ryo Watanabe, Fumiya Saito, Masashi Sakuma, Akiko Haruyama, Hirohisa Amano, Takuo Arikawa, Shigeru Toyoda, Teruo Inoue
We report the case of a 51-year-old female, in whom coronary artery disease such as occlusion of septal perforators was manifested, on the occasion of hospitalization with congestive heart failure. The patient had a history of radiation therapy for a mediastinal tumor 19 years previously. As she had no conventional coronary risk factors, the cause of the coronary artery disease is thought to have been related to the radiation therapy. As survival rates of cancer patients improve as a consequence of therapeutic advances, we should be aware of the possibility of coronary artery disease as a very late complication of radiation therapy, even in patients who have no coronary risk factors...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29150365/correlation-between-ultrasound-appearance-of-small-breast-cancer-and-axillary-lymph-node-metastasis
#8
Xiaoqin Yu, Xiaoyan Hao, Jing Wan, Yingying Wang, Lan Yu, Binyue Liu
To study the correlation of ultrasonographic signs of small breast cancer (maximum diameter ≤2.0 cm) with axillary lymph node metastasis, pre-operative ultrasonographic images of 153 small breast malignant neoplasms in 143 breast cancer patients were analyzed according to their pathologic features. Of the small breast tumors included, 47 showed axillary lymph node metastasis. Diagnosis of all patients was obtained with radical axillary surgery or a sentinel lymph node biopsy procedure. Ultrasonographic signs included irregular shape, microlobulated contour, spiculation, microcalcification, posterior echo attenuation, blood-flow grade, perforating vessels, changes in fascia or cooper's ligament and maximum cortical thickness of lymph nodes...
November 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29149927/gastrointestinal-involvement-in-beh%C3%A3-et-disease
#9
REVIEW
Ibrahim Hatemi, Gulen Hatemi, Aykut Ferhat Çelik
Behçet disease (BD) is a variable vessel vasculitis that can involve several organs and systems. Gastrointestinal (GI) involvement has an acute exacerbating course with ulcers, most commonly in the ileocolonic area. These ulcers can be large and deep, causing perforation and massive bleeding. This article highlights the current knowledge on the epidemiology, clinical findings, diagnosis, and management of GI involvement of BD, with emphasis on recent findings.
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149926/drug-induced-gastrointestinal-and-hepatic-disease-associated-with-biologics-and-nonbiologic-disease-modifying-antirheumatic-drugs
#10
REVIEW
Patrick R Wood, Liron Caplan
A variety of gastrointestinal adverse drug reactions are seen in nearly all conventional antirheumatic medications, ranging from nausea to life-threatening drug-induced liver injury. Rheumatologists should be particularly familiar with hepatotoxicity associated with long-term methotrexate use, and the range of unique hepatic, biliary, and pancreatic manifestations associated with azathioprine. Hepatitis B virus reactivation is the most serious gastrointestinal disease risk associated with many biological therapies, particularly rituximab...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149919/gastrointestinal-and-hepatic-disease-in-vasculitis
#11
REVIEW
Eric Anderson, Neel Gakhar, Courtney Stull, Liron Caplan
Vasculitis is an inflammatory condition that targets the blood vessels, which may occur in isolation or as a component of a systemic inflammatory condition. Although many of the vasculitides can directly affect the organs of the gastrointestinal system, some types exhibit a proclivity for certain gastrointestinal and hepatic organs. Often a patient presents with nonspecific symptoms, delaying the diagnosis and treatment of the underlying vasculitis. Vasculitis can also present with severe manifestations, such as upper gastrointestinal bleeds and bowel perforation...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149508/implementing-quantum-search-algorithm-with-metamaterials
#12
Weixuan Zhang, Kaiyang Cheng, Chao Wu, Yi Wang, Hongqiang Li, Xiangdong Zhang
Metamaterials, artificially structured electromagnetic (EM) materials, have enabled the realization of many unconventional EM properties not found in nature, such as negative refractive index, magnetic response, invisibility cloaking, and so on. Based on these man-made materials with novel EM properties, various devices are designed and realized. However, quantum analog devices based on metamaterials have not been achieved so far. Here, metamaterials are designed and printed to perform quantum search algorithm...
November 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29147757/prospective-evaluation-of-co2-laser-assisted-sclerectomy-surgery-class-with-mitomycin-c
#13
Carlo Alberto Cutolo, Alessandro Bagnis, Riccardo Scotto, Chiara Bonzano, Carlo Enrico Traverso
PURPOSE: Our purpose was to evaluate the clinical safety and efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) with Mitomycin C (MMC) in open angle glaucoma (OAG). METHODS: This was a prospective, uncontrolled, interventional case series. All subjects underwent CLASS procedure by a single surgeon. After the dissection of a partial thickness scleral flap, topical MMC 0.2 mg/ml was applied to the sclera and the conjunctiva for 3 min. The CO2 laser with a beam-manipulating system was used to ablate the scleral tissue and expose the Schlemm's canal area...
November 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29147478/abdominal-pain-with-a-twist-a-rare-presentation-of-acute-gastric-volvulus
#14
David P Chen, Saqib Walayat, Imran L Balouch, Daniel K Martin, Teresa J Lynch
Acute gastric volvulus is a life threatening condition requiring early diagnosis and aggressive management. Diagnosis of gastric volvulus remains a challenge for clinicians due to variable, non-specific clinical presentation, which requires a high level of suspicion. It should be considered in patients presenting with chest pain and/or epigastric pain, especially in the elderly population. Endoscopic de-rotation could be initially attempted as a therapeutic modality especially in patients who cannot undergo surgery...
2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29146893/von-hippel-lindau-disease-with-multi-organ-involvement-a-case-report-and-8-year-clinical-course-with-follow-up
#15
Ali Yaghobi Joybari, Payam Azadeh
BACKGROUND Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome manifested by a spectrum of benign and malignant tumors.  CASE REPORT The patient presented here was a 31-year-old female with unremarkable family history who presented initially complaining of intermittent abdominal pain. Abdominal CT scan revealed an inhomogeneous solid mass (13×9×7 cm) originating from the tail of the pancreas with splenic and gastric invasion as well as several pancreatic cysts. A nucleotide scan showed left adrenal involvement...
November 17, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29146240/channelled-tablets-an-innovative-approach-to-accelerating-drug-release-from-3d-printed-tablets
#16
Muzna Sadia, Basel Arafat, Waqar Ahmed, Robert E Forbes, Mohamed A Alhnan
Conventional immediate release dosage forms involve compressing the powder with a disintegrating agent that enables rapid disintegration and dissolution upon oral ingestion. Among 3D printing technologies, the fused deposition modelling (FDM) 3D printing technique has considerable potential for patient-specific dosage form. However, the use of FDM 3D printing in tablet manufacturing requires large portion of polymer, which slows down drug release through erosion and diffusion mechanisms. In this study, we demonstrate for the first time the use of a novel design approach of caplets with perforating channels to accelerate drug release from 3D printed tablets...
November 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29145325/perforated-appendicitis-after-colonoscopy-cause-or-coincidence-a-rare-case-report-and-literature-review
#17
Xiao-Cong Zhou, Chun-Wei Huang, Yan-Yan Dai, Zhi-Yang Huang, Zheng Lou
RATIONALE: Colonoscopy is a relatively safe and common procedure with low risks of complications, and acute appendicitis with perforation is an extremely rare complication of colonoscopy. The current study presents an unusual case of acute gangrenous appendicitis with perforation following a screening colonoscopy. PATIENT CONCERNS: A 73-year-old man presented to our emergency department with lower right abdominal pain 3 days after a routine screening colonoscopy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144132/large-piezoelectric-effect-in-a-lead-free-molecular-ferroelectric-thin-film
#18
Wei-Qiang Liao, Yuan-Yuan Tang, Peng-Fei Li, Yu-Meng You, Ren-Gen Xiong
Piezoelectric materials have been widely used in various applications, such as high-voltage sources, actuators, sensors, motors, fre-quency standard, vibration reducer, and so on. In the past decades, lead zirconate titanate (PZT) binary ferroelectric ceramics have dominated the commercial piezoelectric market due to their excellent properties near the morphotropic phase boundary (MPB), although they contain more than 60% toxic lead element. Here, we report a lead-free and one-composition molecular ferroelectric trimethylbromomethylammonium tribromomanganese (ΙΙ) (TMBM-MnBr3) with a large piezoelectric coefficient d33 of 112 pC/N along polar axis, comparable with those of typically one-composition piezoceramics such as BaTiO3 along polar axis [001] (~90 pC/N) and much greater than those of most known molecular ferroelectrics (almost below 40 pC/N)...
November 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29143906/surgery-for-diverticular-disease-results-in-a-higher-hernia-rate-compared-to-colorectal-cancer-a-population-based-study-from-ontario-canada
#19
E S Tang, D I Robertson, M Whitehead, J Xu, S F Hall
BACKGROUND: Incisional hernias are a well described complication of abdominal surgery. Previous studies identified malignancy and diverticular disease as risk factors. We compared incisional hernia rates between colon resection for colorectal cancer (CRC) and diverticular disease (DD). STUDY DESIGN: We performed a retrospective, population-based, matched cohort study. Provincial databases were linked through the Institute for Clinical Evaluative Sciences. These databases include all patients registered under the universal Ontario Health Insurance Plan...
November 16, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29143107/how-i-do-it-endoscopic-microvascular-decompression-for-hemifacial-spasm-associated-with-the-vertebral-artery
#20
Fuminari Komatsu, Masaaki Imai, Mitsunori Matsumae
BACKGROUND: Microvascular decompression (MVD) of hemifacial spasm (HFS) associated with the vertebral artery (VA) shows higher rates of incomplete cure and complications compared to non-VA-related HFS. METHOD: Purely endoscopic MVD for VA-associated HFS via a retrosigmoid keyhole was performed. Neurovascular conflicts by a directly offending artery and VA around the root exit zone of the facial nerve were clearly demonstrated under 30° endoscopic view without significant cerebellar retraction...
November 15, 2017: Acta Neurochirurgica
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