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beta blocker sepsis

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https://www.readbyqxmd.com/read/29121280/continuing-chronic-beta-blockade-in-the-acute-phase-of-severe-sepsis-and-septic-shock-is-associated-with-decreased-mortality-rates-up-to-90-days
#1
C Fuchs, S Wauschkuhn, C Scheer, M Vollmer, K Meissner, S-O Kuhn, K Hahnenkamp, A Morelli, M Gründling, S Rehberg
Background: There is growing evidence that beta-blockade may reduce mortality in selected patients with sepsis. However, it is unclear if a pre-existing, chronic oral beta-blocker therapy should be continued or discontinued during the acute phase of severe sepsis and septic shock. Methods: The present secondary analysis of a prospective observational single centre trial compared patient and treatment characteristics, length of stay and mortality rates between adult patients with severe sepsis or septic shock, in whom chronic beta-blocker therapy was continued or discontinued, respectively...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29092973/landiolol-is-effective-for-the-treatment-of-tachycardia-induced-cardiogenic-shock-in-patients-during-septic-shock-therapy
#2
Yoh Arita, Takatsugu Segawa, Shohei Yamamoto, Shinji Hasegawa
Septic shock is a life-threatening condition that occurs when the blood pressure drops to a low level after an infection. Atrial fibrillation (AF) is the most common arrhythmia to complicate its course. Beta (β)-blockers are often administrated to manage supraventricular tachyarrhythmias observed in patients presenting with sepsis. A 74-year-old woman presenting with sepsis demonstrated AF tachycardia characterised by severe hypotension. She was refractory to conventional therapy including verapamil and digoxin; therefore, treatment using landiolol (an ultrashort-acting β-blocker) was initiated...
November 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28927236/beta-blockers-in-sepsis-time-to-reconsider-current-constraints
#3
E C Boerma, M Singer
No abstract text is available yet for this article.
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28720602/a-reminder-of-escherichia-coli-sepsis-induced-reversible-cardiomyopathy
#4
Aung Naing Lin, Atif Shaikh, Sithu Lin, Deepika Misra
Cardiomyopathy is a progressive disease of myocardium causing either mechanical or electrical disturbances. Sepsis-induced cardiomyopathy (SICM) is an entity of cardiomyopathy which is reversible in 1â€"2 weeks after recovery from sepsis or septic shock. SICM is thought to have unpredictable cumulative mortality towards sepsis but its exact mechanism remains elusive. We report a case of Escherichia coli SICM in a 63-year-old woman presented with sudden onset of dyspnoea on exertion and orthopnoea following nausea, vomiting and diarrhoea after consuming Chinese foods...
July 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28666578/outpatient-beta-blockers-and-survival-from-sepsis-results-from-a-national-cohort-of-medicare-beneficiaries
#5
Kathleen E Singer, Courtney E Collins, Julie M Flahive, Allison S Wyman, M Didem Ayturk, Heena P Santry
BACKGROUND: Elderly Americans suffer increased mortality from sepsis. Given that beta-blockers have been shown to be cardioprotective in critical care, we investigated outpatient beta-blocker prescriptions and mortality among Medicare beneficiaries admitted for sepsis. METHODS: We queried a 5% random sample of Medicare beneficiaries for patients admitted with sepsis. We used in-hospital and outpatient prescription drug claims to compare in-hospital and 30-day mortality based on pre-admission beta-blocker prescription and class of beta-blocker prescribed using univariate tests of comparison and multivariable logistic regression models and another class of medications for control...
October 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28658023/preadmission-use-of-calcium-channel-blocking-agents-is-associated-with-improved-outcomes-in-patients-with-sepsis-a-population-based-propensity-score-matched-cohort-study
#6
COMPARATIVE STUDY
Chien-Chang Lee, Meng-Tse Gabriel Lee, Wan-Chien Lee, Chih-Cheng Lai, Christin Chih-Ting Chao, Wan-Ting Hsu Hsu, Shy-Shin Chang, Matthew Lee
OBJECTIVES: Use of calcium channel blockers has been found to improve sepsis outcomes in animal studies and one clinical study. This study determines whether the use of calcium channel blockers is associated with a decreased risk of mortality in patients with sepsis. DESIGN: Population-based matched cohort study. SETTING: National Health Insurance Research Database of Taiwan. PATIENTS: Hospitalized severe sepsis patients identified from National Health Insurance Research Database by International Classification of Diseases, Ninth Revision, Clinical Modification codes...
September 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28458893/successful-treatment-of-thyroid-storm-presenting-as-recurrent-cardiac-arrest-and-subsequent-multiorgan-failure-by-continuous-renal-replacement-therapy
#7
Han Soo Park, Su Kyoung Kwon, Ye Na Kim
SUMMARY: Thyroid storm is a rare and potentially life-threatening medical emergency. We experienced a case of thyroid storm associated with sepsis caused by pneumonia, which had a catastrophic course including recurrent cardiac arrest and subsequent multiple organ failure (MOF). A 22-year-old female patient with a 10-year history of Graves' disease was transferred to our emergency department (ED). She had a cardiac arrest at her home and a second cardiac arrest at the ED. Her heart recovered after 20 min of cardiac resuscitation...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28457762/esmolol-reduces-apoptosis-and-inflammation-in-early-sepsis-rats-with-abdominal-infection
#8
Yang Lu, Yang Yang, Xin He, Shangwen Dong, Wanhua Wang, Donghao Wang, Peng Zhang
BACKGROUND: Esmolol is a highly selective beta 1 receptor blocker with various effects such as slowing heart rate, lowering blood pressure and reducing myocardial oxygen consumption. However, few studies have reported the use of beta blockers in sepsis with multiple organ dysfunctions. This study aimed to investigate the effects of esmolol on reducing apoptosis and inflammation in early sepsis rats with abdominal infection. METHODS: Rats were randomly divided into sham operation group, sepsis group, antibiotic group, Esmolol + antibiotic group with low, median and high dose Esmolol (L group, M group and H group)...
October 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28433104/wilson-disease-symptomatic-liver-therapy
#9
Jan Pfeiffenberger, Karl-Heinz Weiss, Wolfgang Stremmel
Wilson disease leads to symptomatic impairment of liver function or liver cirrhosis. Strict adherence to decoppering agents is essential in these patients. Secondary prevention of additional hepatic damage by avoidance of other toxic substances (e.g., alcohol, drugs) and sufficient calorie intake is recommended. Routine examinations in cirrhotic patients include screening for signs of portal hypertension (esophagus varices), development of ascites, and hepatic encephalopathy. Where varices are present, primary or secondary preventive interventions may include treatment with nonselective beta-blockers or variceal ligation, similar to the approach in patients with liver cirrhosis due to other etiologies...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27290475/90-day-mortality-of-severe-sepsis-and-septic-shock-is-reduced-by-initiation-of-oral-beta-blocker-therapy-and-increased-by-discontinuation-of-a-pre-existing-beta-blocker-treatment
#10
C Fuchs, C Scheer, S Wauschkuhn, M Vollmer, S Rehberg, K Meissner, S O Kuhn, S Friesecke, P Abel, M Gründling
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27269252/esmolol-attenuates-lung-injury-and-inflammation-in-severe-acute-pancreatitis-rats
#11
Luyao Zhang, Yao Nie, Yishan Zheng, Lu Ke, Zhihui Tong, Weiqin Li, Jieshou Li
BACKGROUND: Recent studies suggest that beta-adrenergic blockers attenuate systemic inflammation and improve survival in sepsis. We investigated whether esmolol can reduce lung injury and modulate inflammatory response in a rat model of severe acute pancreatitis (SAP). METHODS: A taurocholate-induced SAP was used, with or without continuously intravenous pumping of esmolol (15 mg/kg/h). Heart rate and arterial pressure were monitored. Nine hrs after esmolol administration, blood was drawn for blood gas analyses and cytokine (interleukin(IL)-6, tumor necrosis factor (TNF)-α) detections, lungs and pancreata were isolated for measurements of myeloperoxidase (MPO) activity and histological damage...
September 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27172161/%C3%AE-blockade-use-for-traumatic-injuries-and-immunomodulation-a-review-of-proposed-mechanisms-and-clinical-evidence
#12
Tyler J Loftus, Philip A Efron, Lyle L Moldawer, Alicia M Mohr
Sympathetic nervous system activation and catecholamine release are important events following injury and infection. The nature and timing of different pathophysiologic insults have significant effects on adrenergic pathways, inflammatory mediators, and the host response. Beta adrenergic receptor blockers (β-blockers) are commonly used for treatment of cardiovascular disease, and recent data suggests that the metabolic and immunomodulatory effects of β-blockers can expand their use. β-blocker therapy can reduce sympathetic activation and hypermetabolism as well as modify glucose homeostasis and cytokine expression...
October 2016: Shock
https://www.readbyqxmd.com/read/27159507/patient-with-eating-disorder-carnitine-deficiency-and-dilated-cardiomyopathy
#13
A Domnica Fotino, A Sherma
Dilated cardiomyopathy is characterized by a dilated and poorly functioning left ventricle and can result from several different etiologies including ischemic, infectious, metabolic, toxins, autoimmune processes or nutritional deficiencies. Carnitine deficiency-induced cardiomyopathy (CDIM) is an uncommon cause of dilated cardiomyopathy that can go untreated if not considered. Here, we describe a 30-year-old woman with an eating disorder and recent percutaneous endoscopic gastrotomy (PEG) tube placement for weight loss admitted to the hospital for possible PEG tube infection...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27138843/initiation-or-maintenance-of-beta-blocker-therapy-in-patients-hospitalized-for-acute-heart-failure
#14
COMPARATIVE STUDY
Luiz Carlos Passos, Márcio Galvão Oliveira, Andre Rodrigues Duraes, Thiago Moreira Trindade, Andréa Cristina Costa Barbosa
Background Beta-blockers have been recommended for patients with heart failure and reduced ejection fraction for their long-term benefits. However, the tolerance to betablockers in patients hospitalized with acute heart failure should be evaluated. Objective To estimate the proportion of patients hospitalized with acute heart failure who can tolerate these agents in clinical practice and compare the clinical outcomes of patients who can and cannot tolerate treatment with beta-blockers. Setting Two reference hospitals in cardiology...
August 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27138534/patient-with-eating-disorder-carnitine-deficiency-and-dilated-cardiomyopathy
#15
A Domnica Fotino Md Mph, A Sherma Md
Dilated cardiomyopathy is characterized by a dilated and poorly functioning left ventricle and can result from several different etiologies including ischemic, infectious, metabolic, toxins, autoimmune processes or nutritional deficiencies. Carnitine deficiency-induced cardiomyopathy (CDIM) is an uncommon cause of dilated cardiomyopathy that can go untreated if not considered. Here, we describe a 30-year-old woman with an eating disorder and recent percutaneous endoscopic gastrotomy (PEG) tube placement for weight loss admitted to the hospital for possible PEG tube infection...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/26700025/care-management-of-the-agitation-or-aggressiveness-crisis-in-patients-with-tbi-systematic-review-of-the-literature-and-practice-recommendations
#16
REVIEW
Jacques Luauté, David Plantier, Laurent Wiart, Laurence Tell
UNLABELLED: The agitation crisis in the awakening phase after traumatic brain injury (TBI) is one of the most difficult behavioral disorders to alleviate. Current treatment options are heterogeneous and may involve excessive sedation. Practice guidelines are required by professionals in charge of TBI patients. Few reviews were published but those are old and based on expert opinions. The purpose of this work is to propose evidence-based guidelines to treat the agitation crisis. METHODS: The elaboration of these guidelines followed the procedure validated by the French health authority for good practice recommendations, close to the Prisma statement...
February 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/26557668/is-it-time-to-beta-block-the-septic-patient
#17
REVIEW
Philip Pemberton, Tonny Veenith, Catherine Snelson, Tony Whitehouse
Beta blockers are some of the most studied drugs in the pharmacopoeia. They are already widely used in medicine for treating hypertension, chronic heart failure, tachyarrhythmias, and tremor. Whilst their use in the immediate perioperative patient has been questioned, the use of esmolol in the patients with established septic shock has been recently reported to have favourable outcomes. In this paper, we review the role of the adrenergic system in sepsis and the evidence for the use of beta stimulation and beta blockers from animal models to critically ill patients...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26270396/practice-patterns-and-outcomes-of-treatments-for-atrial-fibrillation-during-sepsis-a-propensity-matched-cohort-study
#18
Allan J Walkey, Stephen R Evans, Michael R Winter, Emelia J Benjamin
BACKGROUND: Atrial fibrillation (AF) during sepsis is associated with increased morbidity and mortality, but practice patterns and outcomes associated with rate- and rhythm-targeted treatments for AF during sepsis are unclear. METHODS: This was a retrospective cohort study using enhanced billing data from approximately 20% of United States hospitals. We identified factors associated with IV AF treatments (?-blockers [BBs], calcium channel blockers [CCBs], digoxin, or amiodarone) during sepsis...
January 2016: Chest
https://www.readbyqxmd.com/read/26121122/beta-blocker-use-in-severe-sepsis-and-septic-shock-a-systematic-review
#19
REVIEW
Filippo Sanfilippo, Cristina Santonocito, Andrea Morelli, Pierre Foex
OBJECTIVE: Recent growing evidence suggests that beta-blocker treatment could improve cardiovascular dynamics and possibly the outcome of patients admitted to intensive care with severe sepsis or septic shock. DESIGN: Systematic review. DATA SOURCES: MEDLINE and EMBASE healthcare databases. REVIEW METHODS: To investigate this topic, we conducted a systematic review of the above databases up to 31 May 2015. Due to the clinical novelty of the subject, we also included non-randomized clinical studies...
2015: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26109478/safety-of-intravenous-metoprolol-use-in-unmonitored-wards-a-single-centre-observational-study
#20
D Kelly, G Hawdon, J Reeves, A Morris, M Cunningham, J Barrett
BACKGROUND AND AIM: This study aims to examine and quantify the risks associated with the use of intravenous metoprolol on unmonitored wards. METHOD: This study was a retrospective single-centre observational study from 1 January 2009 to 31 December 2013. The study hospital was a 415-bed, private hospital in Melbourne, Victoria. The study population was all patients who received intravenous metoprolol on an unmonitored ward. The primary outcome measure was the rate of serious adverse events (SAE), defined as a complication of intravenous metoprolol resulting in transfer to a critical-care environment, a medical emergency team call or death...
September 2015: Internal Medicine Journal
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