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https://www.readbyqxmd.com/read/29458232/fibrinogen-and-neopterin-is-associated-with-future-myocardial-infarction-and-total-mortality-in-patients-with-stable-coronary-artery-disease
#1
Øistein Rønneberg Mjelva, Gard F T Svingen, Eva K R Pedersen, Reinhard Seifert, Jan Terje Kvaløy, Øivind Midttun, Per M Ueland, Jan E Nordrehaug, Ottar Nygård, Dennis W T Nilsen
Systemic fibrinogen and neopterin are related to inflammation. We investigated the prognostic utility and possible interactions of these biomarkers in stable coronary artery disease (SCAD) patients undergoing coronary angiography. We included 3,545 patients with suspected stable angina with a median follow-up of 7.3 and 10.2 years for incident acute myocardial infarction (AMI) and all-cause mortality, respectively. Prospective associations were explored by Cox regression. Potential effect modifications were investigated according to strata of fibrinogen, neopterin or high-sensitivity troponin T (hsTnT) below and above the median, as well as gender and smoking habits...
February 19, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29458215/factors-associated-with-placental-vascularization-measured-by-3d-power-doppler-ultrasonographic-sphere-biopsy-between-11-and-14-weeks-of-gestation
#2
Suzanne Demers, Amelie Boutin, Regina Dembickaja, Mercedes Campanero, Kypros Nicolaides
OBJECTIVE: Preeclampsia is associated with placental vascularization disorders. Ultrasonographic sphere biopsy (USSB) of the placenta can estimate the vascularization of the placenta and potentially the risk of preeclampsia. We aimed to explore the factors related to placental vascularization measured with USSB in the first trimester. STUDY DESIGN: A prospective cohort was conducted in women recruited at 11 to 14 weeks. Three-dimensional acquisition of the placenta with power Doppler was undertaken along with crown-rump length (CRL)...
February 19, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29458073/establishment-and-validation-of-a-prediction-model-for-ischemic-stroke-risks-in-patients-with-type-2-diabetes
#3
Tsai-Chung Li, Hsiang-Chi Wang, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Cheng-Chieh Lin
AIMS: A risk scoring system for predicting ischemic stroke incidence may identify type 2 diabetes patients at high risk for ischemic stroke who can benefit from preventive intervention programs. Such a risk scoring system can serve as a benchmark to test novel putative risk factors. METHODS: The study adopted a retrospective cohort, including 28,124 Chinese patients with type 2 diabetes aged 30-84 years during 2001-2004. Participants were randomly assigned to the derivation and validation sets at a 2:1 ratio...
February 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29458056/alcohol-and-cv-health-jekyll-and-hyde-j-curves
#4
REVIEW
Evan L O'Keefe, James J Di Nicolantonio, James H O'Keefe, Carl J Lavie
A routine of light or moderate alcohol consumption (≤1 drink/day for women and 1 to 2 drinks/day for men) were associated with a lower risk for all-cause mortality, coronary artery disease (CAD), type 2 diabetes mellitus (T2D), heart failure (HF), and stroke. Conversely, heavy drinking, (>4 drinks/day) is associated with an increased risk for death and cardiovascular (CV) disease (CVD). Excessive alcohol intake trails behind only smoking and obesity among the 3 leading causes of premature deaths in the United States (US)...
February 16, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29457849/tobacco-attributable-burden-of-cancer-according-to-socioeconomic-position-in-france
#5
Gwenn Menvielle, Ivana Kulhánová, Joséphine Bryère, Guy Launoy, Daniel Eilstein, Cyrille Delpierre, Isabelle Soerjomataram
Smoking is a major preventable cause of cancers and is increasingly concentrated among the most deprived individuals leading to increasing socioeconomic inequalities in the incidence of cancers linked to smoking. We aimed to estimate the tobacco-attributable cancer burden according to socioeconomic position in France. The analysis was restricted to cancer sites for which tobacco smoking was recognized as a risk factor. Cancer cases by sex, age group and European Deprivation Index (EDI) among people aged 30-74 between 2006 and 2009 were obtained from cancer registries covering approximately 20% of the French population...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29457844/effect-of-type-d-personality-on-smoking-status-and-their-combined-impact-on-outcome-after-acute-myocardial-infarction
#6
Egidio Imbalzano, Marco Vatrano, Sebastiano Quartuccio, Roberto Ceravolo, Vincenzo Antonio Ciconte, Paola Rotella, Renato Pardeo, Giovanni Trapani, Pasquale De Fazio, Cristina Segura-Garcia, Rossella Costantino, Antonino Saitta, Giuseppe Mandraffino
BACKGROUND: Smoking cessation is correlated with several psychological, social, biological, and pharmacological aspects. The combined tendency to experience negative emotions and to inhibit the expression of these emotions is indicated as "type D personality," an independent risk marker for clinical outcome in cardiac disease. Despite this effect of type D personality on cardiovascular disease, it is still unclear whether this personality trait may influence smoking cessation after a myocardial infarction...
February 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29457499/factors-related-to-alcohol-consumption-among-japanese-physicians
#7
Noriyasu Ohida, Yuichiro Otsuka, Yoshitaka Kaneita, Sachi Nakagome, Maki Jike, Osamu Itani, Takashi Ohida
This study aimed to investigate the drinking habits of Japanese physicians, and clarify their causal factors. A self-administered questionnaire was sent to 6000 male and 1500 female physicians, selected from among members of the Japan Medical Association. We analyzed the correlation of drinking habits with age, medical department, smoking and exercise status, work environment, sleep problems, and mental health. The response rate was 79.4%. Physicians with a heavy drinking habit were most frequently men in their 60s and women in their 20s to 50s...
February 1, 2018: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29457409/-analysis-of-risk-factors-of-infection-for-complex-tibial-plateau-fractures-after-operation
#8
Ju-Lei Ma, Yun-Qin Xu, Tu-Gang Shen, Qiang Li
OBJECTIVE: To analyze the risk factor of infection for complex tibial plateau fractures after operation. METHODS: Totally clinical data of 293 patients with complex tibial plateau fractures underwent open reduction and internal fixation were retrospectively analyzed from September 2010 to March 2015, including 199 males and 94 females, ranging in age from 17 to 80 years old with an average of 47.3 years old. The possible risk factors such as gender, age, smoking, diabetes, type of fracture(open/closed), classification of open fracture(Gustilo-Anderson classification), classification of soft tissue injury in closed fracture (Tscherne-Gotzen classification), fracture classification(Schatzker V/VI), osteofascial compartment syndrome, ASA score, anesthesia, timing of surgery, operative time(<=150 min/>150 min), surgical approach, combined approach or not, internal fixation site were studied...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457219/smokin-hot-adolescent-smoking-and-the-risk-of-psychosis
#9
A Mustonen, T Ahokas, T Nordström, G K Murray, P Mäki, E Jääskeläinen, A Heiskala, J J Mcgrath, J G Scott, J Miettunen, S Niemelä
OBJECTIVE: Daily smoking has been associated with a greater risk of psychosis. However, we are still lacking studies to adjust for baseline psychotic experiences and other substance use. We examined associations between daily smoking and psychosis risk in a 15-year follow-up while accounting for these covariates in a prospective sample (N = 6081) from the Northern Finland Birth Cohort 1986. METHODS: Self-report questionnaires on psychotic experiences (PROD-screen), tobacco smoking and other substance use were completed when the cohort members were 15-16 years old...
February 18, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29457208/children-deserve-smoke-free-world
#10
REVIEW
R Remesh Kumar, P R Jayakumar, R Krishna Mohan
Tobacco smoke, active or passive exposure was the major cause of preventable morbidity and mortality in the world during twentieth century and will continue to be the same in the twenty-first century also if the current trends continue. Both active and passive smoking are having significance in relation to child health. Exposure starts antenatally from placenta to the fetus and later phases through passive exposure to experimental and regular smoking and ultimately addiction and habitual smoking. Evidences are in favour of causal relationship with intrauterine growth restriction, sudden infant death syndrome, decreased pulmonary function, increased risk for respiratory tract infection, otitis media, wheeze, asthma, neurobehavioral disorders, cleft palate and triggering pathogenesis of fetal and childhood onset of adult diseases, especially pulmonary and cardio vascular diseases...
February 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29456958/etiology-of-noise-induced-hearing-loss-nihl-and-its-symptomatic-correlation-with-audiometry-observations-in-type-ii-diabetes
#11
Meena K Yadav, K S Yadav
Type II diabetic mellitus (DM) is a chronic metabolic disease that impairs normal insulin production and glucose transport to the liver and muscles. In the India, about 1-5% population suffer from diabetes or related complication. So there is need to cure this disease. DM chronic auditory complications may include spiral ganglia atrophy, degeneration of the vestibulocochlear nerve myelin sheath, reduction of the number of spiral lamina nerve fibres, and thickening of the capillary walls of the stria vascularis and small arteries...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456910/comparing-the-incidence-of-index-level-fusion-following-minimally-invasive-versus-open-lumbar-microdiscectomy
#12
Steven J McAnany, Samuel C Overley, Muhammad A Anwar, Holt S Cutler, Javier Z Guzman, Jun S Kim, Robert K Merrill, Samuel K Cho, Andrew C Hecht, Sheeraz A Qureshi
Study Design: Retrospective cohort study. Objectives: To determine the incidence of index level fusion following open or minimally invasive lumbar microdiscectomy. Methods: We conducted a retrospective review of 174 patients with a symptomatic single-level lumbar herniated nucleus pulposus who underwent microdiscectomy via a mini-open approach (MIS; 39) or through a minimally invasive dilator tube (135). Outcomes of interest included revision microdiscectomy and the ultimate need for index level fusion...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456848/survival-associated-factors-of-first-line-egfr-tyrosine-kinase-inhibitor-responders-and-non-responders-in-lung-adenocarcinoma-patients-with-common-egfr-mutations
#13
Ming-Szu Hung, Yu-Hung Fang, Yu-Ching Lin, Jr-Hau Lung, Meng-Jer Hsieh, Ying-Huang Tsai
The aim of the present retrospective cohort study was to elucidate the clinical presentation of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) responders and non-responders in lung adenocarcinoma patients with common EGFR mutations. The cohort included 131 lung adenocarcinoma patients with common exon 19 or exon 21 EGFR mutations, who were receiving first-line EGFR-TKI therapy. The patient characteristics, treatment regimen and outcomes were recorded and analyzed. Of the 131 patients, 104 (79...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456763/causal-effect-of-smoking-on-dna-methylation-in-peripheral-blood-a-twin-and-family-study
#14
Shuai Li, Ee Ming Wong, Minh Bui, Tuong L Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S Dite, Graham G Giles, Richard Saffery, Melissa C Southey, John L Hopper
Background: Smoking has been reported to be associated with peripheral blood DNA methylation, but the causal aspects of the association have rarely been investigated. We aimed to investigate the association and underlying causation between smoking and blood methylation. Methods: The methylation profile of DNA from the peripheral blood, collected as dried blood spots stored on Guthrie cards, was measured for 479 Australian women including 66 monozygotic twin pairs, 66 dizygotic twin pairs, and 215 sisters of twins from 130 twin families using the Infinium HumanMethylation450K BeadChip array...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29456681/analysis-of-related-factors-of-surgical-treatment-effect-on-215-patients-with-laryngeal-cancer
#15
Qiong Zhang, Ying Xiong, Ling Lin, Kun Yuan
This study investigated the factors affecting the surgical treatment effect on patients with laryngeal cancer. The clinical data (including the sex, age, smoking index, drinking, primary tumor site, tumor (T) stage, lymph nodes (N) stage, tumor differentiation degree, tumor diameter, surgical method, lymph node metastasis and cervical lymph node dissection) of 215 patients with laryngeal cancer in The Central Hospital of Wuhan were analyzed retrospectively; the survival rate was calculated using the Kaplan-Meier method; log-rank test was used for single-factor analysis, while Cox proportional hazard regression model was used for multiple-factor analysis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456664/jinwei-tang-modulates-hdac2-expression-in-a-rat-model-of-copd
#16
Jianjun Wu, Xin Li, Yang Qin, Juan Cheng, Gaimei Hao, Ruifeng Jin, Chenjun Zhu
The aim of the present study was to investigate the effect of a Traditional Chinese Herbal Medicine (TCHM), named Jinwei Tang on histone deacetylase 2 (HDAC2) and its role in the regulation of corticosteroid resistance in a rat model of chronic obstructive pulmonary disease (COPD). Male Wistar rats were divided into five groups (each n=10): COPD group, established by the intratracheal instillation of lipopolysaccharide and passive smoke exposure, and control, budesonide, theophylline + budesonide and Jinwei Tang + budesonide groups...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456636/expression-of-diaphragmatic-myostatin-and-correlation-with-apoptosis-in-rats-with-chronic-obstructive-pulmonary-disease
#17
Xu Zhou, Daijiao Yi, Yanhong Wu, Xinghua Pei, Haiming Yu, Yanhong Chen, Yu Jiang, Wenpu Li
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function. The present study aimed to investigate the diaphragmatic protein expression of myostatin and its correlation with apoptosis in a rat model of CPOD. Sprague Dawley rats were randomly divided into a control group and a COPD group, the latter of which were exposed to cigarette smoke to build a rat model of COPD. The validity of the COPD model was evaluated by assessment of lung function and histopathological analysis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456589/employment-status-and-changes-in-working-career-in-relation-to-asthma-a-cross-sectional-survey
#18
Saara Taponen, Lauri Lehtimäki, Kirsi Karvala, Ritva Luukkonen, Jukka Uitti
Background: Asthmatics confront inconveniences in working life that make it more difficult to pursue a sustainable career, such as unemployment and work disability. Ways of dealing with these inconveniences may be career changes. More needs to be known about the backgrounds and consequences of career changes among asthmatics, especially their relation to asthma or a change in asthma symptoms. The aim of this study was to compare earlier career changes of adults with asthma who are working full time to those who have drifted away from active working life because of work disability, unemployment or early retirement...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29456398/urinary-cotinine-level-in-indonesian-children-exposed-to-domestic-cigarette-smoke
#19
Agus Dwi Susanto, Priska Duana Putri, Achmad Hudoyo, Feni Fitriani Taufik, Fariz Nurwidya, Sita Andarini
Background: Cotinine is a major metabolite of nicotine, and its urinary level is an indicator of exposure to cigarette smoke. The present study was aimed at identifying the urinary cotinine level in Indonesian children who were exposed and not exposed to domestic cigarette smoke. Methods: The study was a cross-sectional study in elementary school-aged children who had not smoked. The subjects were categorized into an exposed group and unexposed group based on their exposure status...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456347/the-evolving-pattern-and-outcome-of-stroke-at-moderate-altitude
#20
Deepika Dhiman, Sanjay K Mahajan, Sudhir Sharma, Rajiv Raina
Background: The people residing in hills of this Sub-Himalayan region traditionally have a distinct lifestyle involving high level of physical activity. However, increased urbanization in the last two decades has led to changes in lifestyle of people. The present study was an endeavor to document changes in the pattern of stroke in people residing at moderate altitude. Aim: This study was aimed to study the evolving trends in clinical profile, risk factors, and outcome at 3 months in hospitalized patients of stroke in a Tertiary Care Hospital situated at moderate altitude...
January 2018: Journal of Neurosciences in Rural Practice
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