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https://www.readbyqxmd.com/read/28205309/a-feasibility-study-of-a-deuterium-deuterium-neutron-generator-based-boron-neutron-capture-therapy-system-for-treatment-of-brain-tumors
#1
Mindy Hsieh, Yingzi Liu, Farshad Mostafaei, Jean M Poulson, Linda H Nie
PURPOSE: Boron neutron capture therapy (BNCT) is a binary treatment modality that uses high LET particles to achieve tumor cell killing. Deuterium-deuterium (DD) compact neutron generators have advantages over nuclear reactors and large accelerators as the BNCT neutron source, such as their compact size, low cost, and relatively easy installation. The purpose of this study is to design a beam shaping assembly (BSA) for a DD neutron generator and assess the potential of a DD-based BNCT system using Monte Carlo (MC) simulations...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28187142/mosquito-cell-derived-west-nile-virus-replicon-particles-mimic-arbovirus-inoculum-and-have-reduced-spread-in-mice
#2
Brendan T Boylan, Fernando R Moreira, Tim W Carlson, Kristen A Bernard
Half of the human population is at risk of infection by an arthropod-borne virus. Many of these arboviruses, such as West Nile, dengue, and Zika viruses, infect humans by way of a bite from an infected mosquito. This infectious inoculum is insect cell-derived giving the virus particles distinct qualities not present in secondary infectious virus particles produced by infected vertebrate host cells. The insect cell-derived particles differ in the glycosylation of virus structural proteins and the lipid content of the envelope, as well as their induction of cytokines...
February 10, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28182699/bifunctional-effects-of-o-methylated-flavones-from-scutellaria-baicalensis-georgi-on-melanocytes-inhibition-of-melanin-production-and-intracellular-melanosome-transport
#3
Michiko Kudo, Kumiko Kobayashi-Nakamura, Kentaro Tsuji-Naito
The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. Although Scutellaria baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. This study reports three major findings: (1) S. baicalensis has a potent inhibitory effect on melanogenesis; (2) wogonin and its glycoside are the active components of S. baicalensis; and (3) O-methylated flavones from S. baicalensis, such as wogonin, inhibit intracellular melanosome transport...
2017: PloS One
https://www.readbyqxmd.com/read/28178372/antimicrobial-activities-of-phenolic-extracts-derived-from-seed-coats-of-selected-soybean-varieties
#4
Rajaa Abutheraa, Navam Hettiarachchy, Geetha Kumar-Phillips, Ronny Horax, Pengyin Chen, Ruben Morawicki, Young Min Kwon
Soybean hulls or seed coats consist of complex carbohydrates, proteins, lipids, and polyphenols such as anthocyanidins, proanthocyanidins, and isoflavones. The polyphenolics in the seed coats give them various colors such as black, brown, green, yellow, or even a mottled appearance. In this study, the antimicrobial effects of phenolic extracts from the seed coats of different colored soybeans (yellow, dark brown, brown, and black) were evaluated against foodborne pathogens such as Salmonella Typhimurium, Escherichia coli O157:H7, and Campylobacter jejuni in broth-cultures as well as on chicken skin...
February 8, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28174605/plug-in-gait-calculation-of-the-knee-adduction-moment-in-people-with-knee-osteoarthritis-during-shod-walking-comparison-of-two-different-foot-marker-models
#5
Kade L Paterson, Rana S Hinman, Ben R Metcalf, Kim L Bennell, Tim V Wrigley
BACKGROUND: Understanding how kinematic multi-segment foot modelling influences the utility of Plug-in-Gait calculations of the knee adduction moment (KAM) during shod walking is relevant to knee osteoarthritis (OA). Multi-segment foot markers placed on the skin through windows cut in to the shoe provide a more accurate representation of foot mechanics than the traditional marker set used by Plug-in-Gait, which uses fewer markers, placed on the shoe itself. We aimed to investigate whether Plug-in-Gait calculation of the KAM differed when using a kinematic multi-segment foot model compared to the traditional Plug-in-Gait marker set...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28161548/anti-melasma-codrug-of-retinoic-acid-assists-cutaneous-absorption-with-attenuated-skin-irritation
#6
Pei-Wen Hsieh, Chi-Feng Hung, Chih-Hung Lin, Chang-Wei Huang, Jia-You Fang
Melasma treatment with combined retinoic acid (RA) and hydroquinone (HQ) usually causes unsatisfactory outcomes and safety concerns. This study attempted to evaluate the cutaneous absorption and skin tolerance of the codrug conjugated with RA and HQ via ester linkage. The codrug's permeation of the pig skin was estimated using Franz diffusion cell. The codrug and parent drugs were comparatively examined for anti-inflammatory activity and tyrosinase inhibition. In vivo cutaneous irritation was assessed on nude mouse skin...
February 1, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28151818/the-effect-of-fixation-technique-on-continuous-interscalene-nerve-block-catheter-success-a-randomized-double-blind-trial
#7
David B Auyong, David Asher Cantor, Cynthia Green, Neil A Hanson
BACKGROUND: Continuous peripheral nerve blocks offer advantages over single-injection blocks, including extended analgesia and reduction in opioid consumption. These benefits require that the perineural catheter remain intact for the duration of the planned local anesthetic infusion. Mechanical displacement of catheters, leaking, and consequent failure are known complications. The aim of this study was to evaluate continuous perineural catheter tip-to-nerve apposition in vivo over 48 hours comparing 2 different simple fixation strategies...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28146410/almond-skin-polyphenol-extract-inhibits-inflammation-and-promotes-lipolysis-in-differentiated-3t3-l1-adipocytes
#8
Wen-Chung Huang, Chi-Yuan Chen, Shu-Ju Wu
Studies have shown that polyphenols reduce the risk of inflammation-related diseases and upregulates energy expenditure in adipose tissue. Here, we investigated the mechanism of the anti-inflammatory and antiobesity effects of almond skin polyphenol extract (ASP) in differentiated 3T3-L1 adipocytes. The antioxidant effects of ASP were measured based on DPPH radical scavenging activity, Trolox equivalent antioxidant capacity, and total phenolic content. Differentiated 3T3-L1 cells were treated with ASP. Subsequently, lipolysis proteins and transcription factors of adipogenesis were measured...
February 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28143558/lung-metastases-treated-with-stereotactic-body-radiotherapy-the-rssearch%C3%A2-patient-registry-s-experience
#9
Anthony Ricco, Joanne Davis, William Rate, Jun Yang, David Perry, John Pablo, David D'Ambrosio, Sanjeev Sharma, Srinath Sundararaman, James Kolker, Kimberly M Creach, Rachelle Lanciano
OBJECTIVES: To report overall survival and local control for patients identified in the RSSearch® Patient Registry with metastatic cancer to the lung treated with SBRT. METHODS: Seven hundred two patients were identified with lung metastases in the RSSearch® Registry. Of these patients, 577 patients had SBRT dose and fractionation information available. Patients were excluded if they received prior surgery, radiation, or radiofrequency ablation to the SBRT treated area...
February 1, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28138726/reduction-of-radiation-exposure-using-dynamic-trace-digital-angiography-and-spot-fluoroscopy-during-adrenal-venous-sampling
#10
Satoru Morita, Kenji Endo, Shingo Suzaki, Umiko Ishizaki, Hiroshi Yamazaki, Yu Nishina, Shuji Sakai
PURPOSE: To compare radiation exposure of adrenal venous sampling (AVS) using dynamic trace digital angiography (DTDA) and spot fluoroscopy with that using conventional methods. MATERIALS AND METHODS: AVS was performed in 11 patients using DTDA and spot fluoroscopy (Group A) and 11 patients using conventional digital subtraction angiography (DSA) with collimation (Group B). Radiation exposure and image quality of adrenal venography using a five-point scale were compared between the groups...
January 30, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28122479/photoprotection-by-pistachio-bioactives-in-a-3-dimensional-human-skin-equivalent-tissue-model
#11
C-Y Oliver Chen, Avi Smith, Yuntao Liu, Peng Du, Jeffrey B Blumberg, Jonathan Garlick
Reactive oxygen species (ROS) generated during ultraviolet (UV) light exposure can induce skin damage and aging. Antioxidants can provide protection against oxidative injury to skin via "quenching" ROS. Using a validated 3-dimensional (3D) human skin equivalent (HSE) tissue model that closely mimics human skin, we examined whether pistachio antioxidants could protect HSE against UVA-induced damage. Lutein and γ-tocopherol are the predominant lipophilic antioxidants in pistachios; treatment with these compounds prior to UVA exposure protected against morphological changes to the epithelial and connective tissue compartments of HSE...
January 25, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28122160/physicochemical-properties-antioxidant-and-anti-proliferative-capacities-of-dried-leaf-and-its-extract-from-xao-tam-phan-paramignya-trimera
#12
Van Tang Nguyen, Jennette A Sakoff, Christopher J Scarlett
Xao tam phan (P. trimera) has been used for the treatment of cancer and cancer-like aliments. Among different parts of P. trimera plant, leaf is considered as a residual part after harvesting of the root. This study aimed to determine the physiochemical properties, antioxidant and anti-proliferative capacities of P. trimera leaf (PTL) using microwave drying for the preparation of dry sample; methanol and microwave-assisted extraction for the preparation of crude extract; and freeze drying for the preparation of powdered extract...
January 25, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28121869/blood-congestion-can-be-rescued-by-hemodilution-in-a-random-pattern-skin-flap
#13
Koji Kanayama, Kazuhide Mineda, Takanobu Mashiko, Szu-Hsien Wu, Jingwei Feng, Kahori Kinoshita, Ataru Sunaga, Kotaro Yoshimura
BACKGROUND: There is no standard method to ensure survival of random-pattern skin flaps. The authors developed a rat anemia model to observe survival of random-pattern skin flaps after blood transfusion and hemodilution. METHODS: Anemia was induced by withdrawal of 35 percent blood volume followed by compensation with the same amount of blood (blood transfusion model) or plasma equivalent (normovolemic hemodilution). Control rats were subjected to a sham procedure...
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28115962/image-guided-high-dose-rate-brachytherapy-of-head-and-neck-a-case-series-study
#14
Paweł Cisek, Dariusz Kieszko, Anna Brzozowska, Izabela Kordzin'ska-Cisek, Maria Mazurkiewicz
PURPOSE: The aim of the study was the evaluation of image guided transdermal application of interstitial brachytherapy in patients undergoing repeated irradiation for relapsed local tumor of the head and neck area. MATERIAL AND METHODS: The article describes transdermal application of interstitial high-dose-rate (HDR) brachytherapy in 4 patients treated due to relapsed local tumor in soft palate, submandibular area, laryngopharynx, as well as pterygoid muscles and maxillary sinus...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28115904/evaluation-of-polyphenol-content-and-antioxidant-capacity-of-fruits-and-vegetables-using-a-modified-enzymatic-extraction
#15
Rudy Álvarez, Héctor Araya, Rosa Navarro-Lisboa, Carol Lopez de Dicastillo
Fruits and vegetables are considered a good source of polyphenols and antioxidant capacities which are beneficial in protecting the human body against damage induced by reactive species. The objective of this work is to conduct an assessment of the polyphenol content and antioxidant activities of different fruit (kiwi, pear, green apple, raspberry, blackberry, strawberry and blueberry) and vegetable (pumpkin, green and red pepper) extracts using both chemical extraction and a modified in vitro digestive enzymatic extraction in order to compare results...
December 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/28112800/comparison-of-the-paper-based-and-electronic-versions-of-the-dermatology-life-quality-index-dlqi-evidence-of-equivalence
#16
F M Ali, N Johns, A Finlay, M S Salek, V Piguet
BACKGROUND: The use of patient-reported outcome measures in electronic format has been increasing. However, these formats are usually not validated or compared to the original paper-based formats, so there is no evidence that they are completed in the same way. OBJECTIVES: The aim of this study was to compare the conventional paper version and a web-based application version (iPad(®) ) of the DLQI to assess equivalence of scores. METHODS: The study employed a randomized cross-over design using a within-subjects comparison of the two formats of the questionnaire...
January 23, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28111928/electrospun-poly-hydroxybutyrate-scaffolds-promote-engraftment-of-human-skin-equivalents-via-macrophage-m2-polarization-and-angiogenesis
#17
Delia Castellano, Ana Sanchis, María Blanes, Mª Dolores Pérez Del Caz, Amparo Ruiz-Saurí, Marina Piquer, Beatriz Pelacho, B Marco, Nahuel Garcia, Imelda Ontoria-Oviedo, Vicente Cambra, Felipe Prosper, Pilar Sepúlveda
Human dermo-epidermal skin equivalents (DE) comprising in vitro expanded autologous keratinocytes and fibroblasts are a good option for massive burn treatment. However, the lengthy expansion time required to obtain sufficient surface to cover an extensive burn together with the challenging surgical procedure limits their clinical use. The integration of DE and biodegradable scaffolds has been proposed in an effort to enhance their mechanical properties. Here, we show that poly(hydroxybutyrate) electrospun scaffolds (PHB) present good biocompatibility both in vitro and in vivo and are superior to poly-ε-caprolactone electrospun scaffolds (PCL) as a substrate for skin reconstruction...
January 23, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28103388/climbazole-boosts-activity-of-retinoids-in-skin
#18
Jean Adamus, Li Feng, Stacy Hawkins, Kristopher Kalleberg, Jian-Ming Lee
OBJECTIVE: To explore if climbazole enhances retinoid-associated biological activities in vitro and in vivo. METHODS: Primary human dermal fibroblasts (HDFs) were treated from six to 48 hours with either retinoids (retinol, retinyl propionate, retinyl palmitate) alone or in combination with climbazole, then assessed for cellular retinoic acid-binding protein 2 (CRABP2) mRNA expression by RT-qPCR. Next, skin equivalent (SE) cultures were topically treated with a retinol or retinyl propionate, and with or without climbazole, then measured for biological changes in retinoid biomarkers...
January 19, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28102826/ceramic-particle-engulfment-by-fibroblasts-does-not-alter-at-all-cell-behavior
#19
Pierre-Antoine Faye, Olivier Roualdes, Fabrice Rossignol, Daniel Jean Hartmann, Alexis Desmoulière
Despite many studies, the impact of ceramic particles on cell behavior remains still unclear. The aim of the present study was to investigate the effects of ceramic nano-sized particles on fibroblastic cells. Fibroblasts (dermal fibroblasts freshly isolated from skin samples and WI26 fibroblastic cells) were cultured in monolayer in the presence of alumina or cerium-zirconia particles (��� 50 nm diameter) at two concentrations (100 or 500 ��g.mL-1). Fluorescent alumina particles were also used. Cell morphology, cytoplasmic ceramic incorporation using confocal and transmission electron microscopy, and migration using silicon insert, were analyzed...
January 19, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28101566/effect-of-physical-activity-in-the-first-five-days-after-cardiac-surgery
#20
Sean F Mungovan, Preetraj Singh, Gregory C Gass, Neil A Smart, Andrew D Hirschhorn
OBJECTIVES: To quantify physiotherapist-supervised and independent physical activity undertaken from the first to the fifth day after cardiac surgery (POD1 to POD5), and to relate the amount of physical activity undertaken with hospital stay and postoperative physiological functional capacity on POD6. METHODS: Physiotherapist-supervised and independent physical activity were monitored in 83 adult patients undergoing cardiac surgery, using a bi-axial accelerometer and skin sensors that measured, galvanic skin response and body temperature...
January 19, 2017: Journal of Rehabilitation Medicine
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