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https://www.readbyqxmd.com/read/29352285/deep-neural-networks-show-an-equivalent-and-often-superior-performance-to-dermatologists-in-onychomycosis-diagnosis-automatic-construction-of-onychomycosis-datasets-by-region-based-convolutional-deep-neural-network
#1
Seung Seog Han, Gyeong Hun Park, Woohyung Lim, Myoung Shin Kim, Jung Im Na, Ilwoo Park, Sung Eun Chang
Although there have been reports of the successful diagnosis of skin disorders using deep learning, unrealistically large clinical image datasets are required for artificial intelligence (AI) training. We created datasets of standardized nail images using a region-based convolutional neural network (R-CNN) trained to distinguish the nail from the background. We used R-CNN to generate training datasets of 49,567 images, which we then used to fine-tune the ResNet-152 and VGG-19 models. The validation datasets comprised 100 and 194 images from Inje University (B1 and B2 datasets, respectively), 125 images from Hallym University (C dataset), and 939 images from Seoul National University (D dataset)...
2018: PloS One
https://www.readbyqxmd.com/read/29345319/endothelial-cells-enhance-adipose-mesenchymal-stromal-cell-mediated-matrix-contraction-via-alk-receptors-and-reduced-follistatin-potential-role-of-endothelial-cells-in-skin-fibrosis
#2
Hanneke N Monsuur, Lenie J van den Broek, Pieter Koolwijk, Frank B Niessen, Susan Gibbs
Abnormal cutaneous wound healing can lead to formation of fibrotic hypertrophic scars. Although several clinical risk factors have been described, the cross-talk between different cell types resulting in hypertrophic scar formation is still poorly understood. The aim of this in vitro study was to investigate whether endothelial cells (EC) may play a role in skin fibrosis, e.g. hypertrophic scar formation after full-thickness skin trauma. Using a collagen/elastin matrix, we developed an in vitro fibrosis model to study the interaction between EC and dermal fibroblasts or adipose tissue-derived mesenchymal stromal cells (ASC)...
January 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29334624/adequate-vitamin-d3-skin-synthesis-versus-erythema-risk-in-the-northern-hemisphere-midlatitudes
#3
Jakub Guzikowski, Janusz Krzyścin, Agnieszka Czerwińska, Weronika Raszewska
Health-optimum-exposure index (HOEI) is proposed to assess if the prescribed amount of vitamin D3 (target value) could be synthesized in the human skin without erythema appearance. It is defined as the ratio between the vitamin D3 quantity received during the maximum allowed outdoor exposure without erythema risk and the target value. Sunbathing is safe for HOEI>1 and 1/HOEI represents a part of minimal erythema dose (MED) necessary to obtain the target value. We examine the following targets: a vitamin D3 quantity equivalent to 1000 IU vitamin D3 taken orally, and an optimal vitamin D3 quantity defined by Krzyścin et al...
January 11, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29333393/effect-of-monascus-fermented-soybean-extracts-on-antioxidant-and-skin-aging-related-enzymes-inhibitory-activities
#4
Yoo-Jeong Jin, Young-Hee Pyo
We investigated the in vitro inhibitory activity against skin aging-related enzymes and antioxidant activity of Monascus-fermented soybean extracts (MFSEs) obtained by using different solvents. The highest Trolox equivalent (TE) antioxidant capacity (3.13±0.06 mM TE/g) and oxygen radical absorbance capacity (2.79±0.09 mM TE/g) of MFSEs were evaluated for the methanol and 80% ethanol extracts, respectively. The antioxidant capacities increased with increasing concentration (0.5~50 mg/mL). In addition, the methanol and 80% ethanol extracts showed an effective inhibition against tyrosinase, hyaluronidase, and elastase compared with those of acetone and hot water extracts (P<0...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29332575/protective-role-of-italian-juglans-regia-l-nut-ethanolic-extract-in-human-keratinocytes-under-oxidative-and-inflammatory-stress
#5
Cinzia Calcabrini, Umberto Mancini, Roberta De Bellis, Alessandra Frati, Anna Rita Mastrogiacomo, Giosue Annibalini, Piero Sestili, Luigi Cucchiarini, Vilberto Stocchi, Lucia Potenza
OBJECTIVE: In this research, fatty acid profile and polyphenolic content of an ethanolic extract of walnut from Juglans regia L. collected in Central Italy, were performed. The potential antioxidant and anti-inflammatory effects of the extract were investigated in the human keratinocytes cell line. METHODS: Fatty acid profile was determined by gas chromatography/mass spectrometry analysis, total phenolic content by Folin-Ciocalteu method and aluminum chloride colorimetric method was used for determination of total flavonoids...
January 12, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29330036/regulation-of-fibrotic-changes-by-the-synergistic-effects-of-cytokines-dimensionality-and-matrix-towards-the-development-of-an-in-vitro-human-dermal-hypertrophic-scar-model
#6
Shikha Chawla, Sourabh Ghosh
Current therapeutic strategies to reduce scarring in full thickness skin defect offer limited success due to poor understanding of scar tissue formation and the underlying signaling pathways. There is an urgent need to develop human cell based in vitro scar tissue models as animal testing is associated with ethical and logistic complications and inter-species variations. Pro-inflammatory cytokines play critical role in regulating scar development through complex interplay and interaction with the ECM and corresponding signaling pathways...
January 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29328968/in-vitro-examination-of-an-oleosome-based-sun-protection-product-on-the-influence-of-uvb-induced-inflammation-markers-in-human-epidermal-skin-equivalent-tissue-model
#7
James V Gruber, Robert Holtz, Soo In Yang
In vitro human epidermal skin equivalent tissues (MatTek EpiDerm™) were employed to examine the influence of UVB radiation on various established inflammation markers in the presence of topically applied sunscreens. MatTek EpiDerm™ tissues were treated with 2.0mg/cm2 of an Experimental oleosome-based SPF 30 product or a commercial SPF 30 beach product. Tissues were irradiated with 300mJ/cm2 of UVB radiation. Inflammatory cytokines IL-1α, IL-6 and IL-8 as well as arachidonic acid cascade marker PGE2 were examined via ELISA-based antibody detection...
December 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29324427/lemons-in-the-arizona-sunshine-the-effects-of-furocoumarins-leading-to-phytophotodermatitis-and-burn-like-injuries
#8
Marc R Matthews, Joel C VanderVelde, Daniel M Caruso, Kevin N Foster
INTRODUCTION: Phytophototoxic dermatitis is a strong phototoxic reaction to ultraviolet A (UV-A) radiation exposure after cutaneous contact with citrus fruit containing furocoumarins, leading to skin injury. At the Arizona Burn Center (Phoenix, AZ), the majority of these injuries are managed in the outpatient setting. CASE REPORT: The authors present a pediatric admission for burn-like injuries following prolonged cutaneous exposure to lemons while playing in the Arizona sunshine...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29313702/a-comparison-of-scaffold-free-and-scaffold-based-reconstructed-human-skin-models-as-alternatives-to-animal-use
#9
Beste Kinikoglu
Tissue engineered full-thickness human skin substitutes have various applications in the clinic and in the laboratory, such as in the treatment of burns or deep skin defects, and as reconstructed human skin models in the safety testing of drugs and cosmetics and in the fundamental study of skin biology and pathology. So far, different approaches have been proposed for the generation of reconstructed skin, each with its own advantages and disadvantages. Here, the classic tissue engineering approach, based on cell-seeded polymeric scaffolds, is compared with the less-studied cell self-assembly approach, where the cells are coaxed to synthesise their own extracellular matrix (ECM)...
December 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29303437/the-age-related-positivity-effect-in-electronic-gambling
#10
Phoebe E Bailey, Craig J Gonsalvez, Michelle Maiuolo, Tarren Leon, Gülten Benedek
BACKGROUND: Older adults are increasingly spending time and money playing electronic gambling machines (EGMs). The current study assessed whether the age-related positivity effect influences responding to various EGM outcomes, including wins and losses of equivalent magnitude and frequency. We also explored cognitive mechanisms potentially underpinning the positivity effect. METHODS: We recorded the skin conductance response (SCR) of healthy older and younger adults while they played for wins, losses, and fake wins (losses disguised as wins)...
January 5, 2018: Experimental Aging Research
https://www.readbyqxmd.com/read/29290820/breaking-the-barrier-potent-anti-inflammatory-activity-following-efficient-topical-delivery-of-etanercept-using-thermoresponsive-nanogels
#11
M Giulbudagian, G Yealland, S Hönzke, A Edlich, B Geisendörfer, B Kleuser, S Hedtrich, M Calderón
Topical administration permits targeted, sustained delivery of therapeutics to human skin. Delivery to the skin, however, is typically limited to lipophilic molecules with molecular weight of < 500 Da, capable of crossing the stratum corneum. Nevertheless, there are indications protein delivery may be possible in barrier deficient skin, a condition found in several inflammatory skin diseases such as psoriasis, using novel nanocarrier systems. METHODS: Water in water thermo-nanoprecipitation; dynamic light scattering; zeta potential measurement; nanoparticle tracking analysis; atomic force microscopy; cryogenic transmission electron microscopy; UV absorption; centrifugal separation membranes; bicinchoninic acid assay; circular dichroism; TNFα binding ELISA; inflammatory skin equivalent construction; human skin biopsies; immunohistochemistry; fluorescence microscopy; western blot; monocyte derived Langerhans cells; ELISA Results: Here, we report the novel synthesis of thermoresponsive nanogels (tNG) and the stable encapsulation of the anti-TNFα fusion protein etanercept (ETR) (~150 kDa) without alteration to its structure, as well as temperature triggered release from the tNGs...
2018: Theranostics
https://www.readbyqxmd.com/read/29283384/high-mobility-group-box-1-mediates-fibroblast-activity-via-rage-mapk-and-nf-%C3%AE%C2%BAb-signaling-in-keloid-scar-formation
#12
Jihee Kim, Jong-Chul Park, Mi Hee Lee, Chae Eun Yang, Ju Hee Lee, Won Jai Lee
Emerging studies have revealed the involvement of high-mobility group box 1 (HMGB1) in systemic fibrotic diseases, yet its role in the cutaneous scarring process has not yet been investigated. We hypothesized that HMGB1 may promote fibroblast activity to cause abnormal cutaneous scarring. In vitro wound healing assay with normal and keloid fibroblasts demonstrated that HMGB1 administration promoted the migration of both fibroblasts with increased speed and a greater traveling distance. Treatment of the HMGB1 inhibitor glycyrrhizic acid (GA) showed an opposing effect on both activities...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29277438/hazardous-parameters-associated-with-natural-radioactivity-exposure-from-black-sand
#13
M A Hilal, E H Borai
Black sand samples collected from Baltim beaches (Kafr El-Sheikh governorate) in Egypt on the Mediterranean Sea shore were analyzed radiometrically and evaluated using a nondestructive gamma ray spectroscopic techniques. The natural radionuclides of 226Ra, 232Th and 40K in the black sand samples were identified and quantified. It is found that the activity concentrations for 226Ra, 232Th and 40K in different eleven sites (S1S11) were found within the ranges of 28-322, 91-308 and 81-339 Bq/kg, respectively. Moreover, different radiological hazardous parameters (absorbed dose rate, annual effective dose equivalent, radium activity, annual gonadal dose equivalent and excess lifetime cancer risk) were calculated...
December 22, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29275070/parent-participation-in-the-neonatal-intensive-care-unit-predictors-and-relationships-to-neurobehavior-and-developmental-outcomes
#14
Roberta Pineda, Joy Bender, Bailey Hall, Lisa Shabosky, Anna Annecca, Joan Smith
OBJECTIVE: To 1) define predictors of parent presence, any holding, holding in arms, and skin-to-skin care in the NICU and 2) investigate the relationships between parent participation and a) early neurobehavior and b) developmental outcomes at age 4 to 5years among preterm infants. METHODS: Eighty-one preterm infants born ≤32weeks estimated gestational age were prospectively enrolled within one week of life in a level III-IV NICU. Parent (maternal and paternal) presence and holding (including holding in arms and skin-to-skin care) were tracked throughout NICU hospitalization...
December 21, 2017: Early Human Development
https://www.readbyqxmd.com/read/29249529/optimal-high-dose-rate-brachytherapy-fractionation-scheme-after-keloid-excision-a%C3%A2-retrospective-multicenter-comparison-of-recurrence-rates-and-complications
#15
Eveline Bijlard, Gerda M Verduijn, J X Harmeling, Homan Dehnad, Frank B Niessen, Otto W M Meijer, Marc A M Mureau
PURPOSE: To determine the optimal brachytherapy dose and fractionation scheme for keloid treatment. METHODS AND MATERIALS: Patient cohorts from 3 centers treated with keloid excision followed by 2 × 9 Gy, 3 × 6 Gy, or 2 × 6 Gy high-dose-rate brachytherapy were retrospectively compared regarding recurrence (after at least 12 months' follow-up) and complications (after at least 1 month's follow-up), using logistic regression analyses. RESULTS: A total of 238 keloids were treated...
November 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29244224/osteochondral-repair-using-an-acellular-dermal-matrix-pilot-in-vivo-study-in-a-rabbit-osteochondral-defect-model
#16
Ken Ye, Kathy Traianedes, Shalley A Robins, Peter F M Choong, Damian E Myers
The aim of this pilot project was to introduce a novel use of acellular dermal matrix (ADM) in combination with infrapatellar fat pad mesenchymal stromal cells (IPFP-MSCs) to effect repair in a rabbit osteochondral defect model. ADM, in a range of surgical procedures, has been shown to promote remodelling of tissue at the site of implantation. Rabbit-derived ADM (rabADM) was prepared from the skin of donor rabbits. Autologous IPFP-MSCs were obtained at the time of knee surgery. Osteochondral defects (4mm cartilage outer/2mm central bone defect) were drilled into distal femoral condyles of 12 New Zealand White rabbits...
December 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29240589/infrared-skin-thermometry-validating-and-comparing-techniques-to-detect-periwound-skin-infection
#17
Asfandyar Mufti, Ranjani Somayaji, Patricia Coutts, R Gary Sibbald
OBJECTIVE: Diagnosis of wound infection can be challenging because it relies on a combination of clinical signs and symptoms that are often nonspecific. Increased periwound cutaneous temperature is a classic sign of deep and surrounding wound infection, and its quantitative measurement is one of the most reliable and valid clinical signs of deep and surrounding skin infection at the bedside. Skin surface temperature differences may be detected using commercially available noncontact infrared thermometers...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29239813/experimental-assessment-of-the-advanced-collapsed-cone-engine-for-scalp-brachytherapy-treatments
#18
Brie Cawston-Grant, Hali Morrison, Ron S Sloboda, Geetha Menon
PURPOSE: To experimentally assess the performance of the Advanced Collapsed-cone Engine (ACE) for 192Ir high-dose-rate brachytherapy treatment planning of nonmelanoma skin cancers of the scalp. METHODS AND MATERIALS: A layered slab phantom was designed to model the head (skin, skull, and brain) and surface treatment mold using tissue equivalent materials. Six variations of the phantom were created by varying skin thickness, skull thickness, and size of air gap between the mold and skin...
November 24, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29239083/physical-growth-and-diets-of-school-children-trends-from-2001-to-2015-in-rural-west-java-indonesia
#19
Makiko Sekiyama, Katrin Roosita, Ryutaro Ohtsuka
OBJECTIVES: This study aimed to assess changes in physical growth and diets of school children in rural West Java, Indonesia, between 2001 and 2015, a period of rapid socioeconomic change. METHODS: In 2001 and 2015, anthropometric measurements (height, weight, mid-upper arm circumference, skin-fold thickness), food consumption surveys, and questionnaires on socioeconomic status were completed by fourth-grade school children in a rural village in West Java. RESULTS: Height increments of 5...
December 14, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29232889/preparation-characterization-and-biological-activities-of-topical-anti-aging-ingredients-in-a-citrus-junos-callus-extract
#20
Deepak Adhikari, Vijay Kumar Panthi, Rudra Pangeni, Hyun Jung Kim, Jin Woo Park
In this study, we prepared and characterized a callus extract from Citrus junos and assessed its utility as a source of topical anti-aging ingredients. Callus extract was produced by aqueous extraction from Citrus junos grown on Murashige and Skoog medium with picloram as a growth regulator. After measuring the total phenolic and flavonoid contents, the major phenolic compound in calli was identified as p-hydroxycinnamoylmalic acid (1) by spectroscopic analysis. The total phenol content in the extract was determined to be 24...
December 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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