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https://www.readbyqxmd.com/read/28088483/physiology-recording-with-magnetic-field-probes-for-fmri-denoising
#1
Simon Gross, Laetitia Vionnet, Lars Kasper, Benjamin E Dietrich, Klaas P Pruessmann
Physiological noise originating in cardiovascular and respiratory processes is a substantial confound in BOLD fMRI. When unaccounted for it reduces the temporal SNR and causes error in inferred brain activity and connectivity. Physiology correction typically relies on auxiliary measurements with peripheral devices such as ECG, pulse oximeters, and breathing belts. These require direct skin contact or at least a tight fit, impairing subject comfort and adding to the setup time. In this work, we explore a touch-free alternative for physiology recording, using magnetic detection with NMR field probes...
January 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28087382/efficacy-and-safety-of-high-dose-rush-oral-immunotherapy-in-persistent-egg-allergic-children-a-randomized-clinical-trial
#2
Inmaculada Pérez-Rangel, Pablo Rodríguez Del Río, Carmelo Escudero, Silvia Sánchez-García, José Javier Sánchez-Hernández, María Dolores Ibáñez
BACKGROUND: Egg oral immunotherapy is effective but time consuming. OBJECTIVE: To assess the efficacy and safety of egg rush oral immunotherapy (ROIT) with a targeted dose equivalent to a raw egg white. METHODS: Thirty-three persistent egg allergic children confirmed by double-blind, placebo-controlled food challenge (DBPCFC) were randomized to receive egg ROIT immediately after randomization (ROIT1 group), or to continue an egg avoidance diet for 5 months after randomization (control group [CG])...
January 10, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28080988/medical-mycology-and-fungal-immunology-new-research-perspectives-addressing-a-major-world-health-challenge
#3
REVIEW
Neil A R Gow, Mihai G Netea
Fungi cause more than a billion skin infections, more than 100 million mucosal infections, 10 million serious allergies and more than a million deaths each year. Global mortality owing to fungal infections is greater than for malaria and breast cancer and is equivalent to that owing to tuberculosis (TB) and HIV. These statistics evidence fungal infections as a major threat to human health and a major burden to healthcare budgets worldwide. Those patients who are at greatest risk of life-threatening fungal infections include those who have weakened immunity or have suffered trauma or other predisposing infections such as HIV...
December 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28079753/synergistic-effects-of-serotonin-or-dopamine-combined-with-lidocaine-at-producing-nociceptive-block-in-rats
#4
Ching-Hsia Hung, Chong-Chi Chiu, Kuo-Sheng Liu, Yu-Wen Chen, Jhi-Joung Wang
BACKGROUND: The purpose of this experiment was to investigate the interactions of the local anesthetic lidocaine combined with an agent (serotonin or dopamine) as infiltrative anesthetics. METHODS: Cutaneous analgesia was characterized by the blockade of the cutaneous trunci muscle reflex following 6 skin pinpricks on the rat back. Serotonin or dopamine at producing cutaneous analgesia in a dosage-dependent fashion was compared with lidocaine. Drug-drug interactions were calculated using the isobolographic analysis...
January 11, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28072577/feasibility-of-tungsten-functional-paper-in-electron-grid-therapy-a-monte-carlo-study
#5
Mikoto Tamura, Hajime Monzen, Kazuki Kubo, Makoto Hirata, Yasumasa Nishimura
Electron grid therapy is expected to be a valid treatment for bulky superficial tumors. It is difficult, however, to fit irradiation fields to bulky superficial tumor shapes for conventional electron grid therapy with a cerrobend grid collimator. In this study, we investigated whether a grid collimator using tungsten functional paper (TFP), with its radiation shielding ability, could be used for electron grid therapy. Dose distributions were measured using 9 MeV electron grid beams from a cerrobend grid collimator...
January 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28058731/improved-intercostal-hifu-ablation-using-a-phased-array-transducer-based-on-fermat-s-spiral-and-voronoi-tessellation-a-numerical-evaluation
#6
Pascal Ramaekers, Mario Ries, Chrit T W Moonen, Martijn de Greef
PURPOSE: A major complication for abdominal High Intensity Focused Ultrasound (HIFU) applications is the obstruction of the acoustic beam path by the thoracic cage, which absorbs and reflects the ultrasonic energy leading to undesired overheating of healthy tissues in the pre-focal area. Prior work has investigated the determination of optimized transducer apodization laws, which allow for a reduced rib exposure whilst (partially) restoring focal point intensity through power compensation...
January 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28048707/mo-fg-campus-jep1-05-water-equivalent-path-length-calculations-using-scatter-corrected-head-and-neck-cbct-images-to-evaluate-patients-for-adaptive-proton-therapy
#7
J Kim, Y Park, G Sharp, B Winey
PURPOSE: To establish a method to evaluate the dosimetric impact of anatomic changes in head and neck patients during proton therapy by using scatter-corrected cone-beam CT (CBCT) images. METHODS: The water equivalent path length (WEPL) was calculated to the distal edge of PTV contours by using tomographic images available for six head and neck patients received photon therapy. The proton range variation was measured by calculating the difference between the distal WEPLs calculated with the planning CT and weekly treatment CBCT images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048468/su-d-209-06-study-on-the-dose-conversion-coefficients-in-pediatric-radiography-with-the-development-of-children-voxel-phantoms
#8
Q Liu, W Zhuo, H Liu, Y Liu, T Chen
PURPOSE: Conversion coefficients of organ dose normalized to entrance skin dose (ESD) are widely used to evaluate the organ doses directly using ESD without time-consuming dose measurement, this work aims to investigate the dose conversion coefficients in pediatric chest and abdomen radiography with the development of 5 years and 10 years old children voxel phantoms. METHODS: After segmentation of organs and tissues from CT slice images of ATOM tissue-equivalent phantoms, a 5-year-old and a 10-year-old children computational voxel phantoms were developed for Monte Carlo simulation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048434/su-f-t-654-pacemaker-dose-estimate-using-optically-stimulated-luminescent-dosimeter-for-left-breast-intraoperative-radiation-therapy
#9
Y Chen, A Goenka, A Sharma, L Wang, Y Cao, A Jamshidi
PURPOSE: To assess and report the in vivo dose for a patient with a pacemaker being treated in left breast intraoperative radiation therapy (IORT). The ZEISS Intrabeam 50 kVp X-ray beam with a spherical applicator was used. METHODS: The optically stimulated luminescent dosimeters (OSLDs) (Landauer nanoDots) were employed and calibrated under the conditions of the Intrabeam 50 kVp X-rays. The nanoDots were placed on the patient at approximately 15 cm away from the lumpectomy cavity both under and above a shield of lead equivalence 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047856/su-f-t-500-the-effectiveness-of-a-patient-specific-bolus-made-by-using-three-dimensional-printing-technique-in-photon-radiotherapy
#10
K Fujimoto, T Shiinoki, Y Yuasa, H Hanazawa, K Shibuya
PURPOSE: A commercially available bolus (commercial-bolus) would not completely contact with the irregular shape of a patient's skin. The purposes of this study were to customize a patient specific three-dimensional (3D) bolus using a 3D printer (3D-bolus) and to evaluate its clinical feasibility for photon radiotherapy. METHODS: The 3D-bolus was designed using a treatment planning system (TPS) in DICOM-RT format. To print the 3D bolus, the file was converted into stereolithography format...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047009/su-f-j-181-an-alternative-patient-alignment-tool-on-tomotherapy-the-first-in-human-megavoltage-topogram-acquisition
#11
L Yang, D Low, P Lee, D Ruan, R Chin, T Kaprealian, M Kamrava, P Kupelian, P Beron, M Steinberg, A Chen, N Agazaryan, S Ray, X Qi
PURPOSE: To show the first in-human Megavoltage (MV)-Topogram acquisition for the evaluation of the potential for MV-Topogram-based alignment as an alternative to MVCT for reducing dose and imaging time. METHODS: A lung cancer patient was enrolled in an ongoing IRB-approved clinical trial at our institute. The patient was set up using the clinical protocol employing positioning lasers. 3.2mm diameter tungsten spheres were placed on the patient's skin at their alignment tattoos to check surface-based marker concordance between topograms and MVCT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046786/su-f-t-133-uniform-scanning-proton-therapy-for-lung-cancer-toxicity-and-its-correlation-with-dosimetry
#12
Y Zheng, S Rana, G Larson
PURPOSE: To analyze the toxicity of uniform scanning proton therapy for lung cancer patients and its correlation with dose distribution. METHODS: In this study, we analyzed the toxicity of 128 lung cancer patients, including 18 small cell lung cancer and 110 non small cell lung cancer patients. Each patient was treated with uniform scanning proton beams at our center using typically 2-4 fields. The prescription was typically 74 Cobalt gray equivalent (CGE) at 2 CGE per fraction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046746/su-f-t-151-measurement-evaluation-of-skin-dose-in-scanning-proton-beam-therapy-for-breast-cancer
#13
J Yu, E Nichols, D Strauss, H Chung, U Langner, K Langen
PURPOSE: To measure the skin dose and compare it with the calculated dose from a treatment planning system (TPS) for breast cancer treatment using scanning proton beam therapy (SPBT). METHODS: A single en-face-beam SPBT plan was generated by a commercial TPS for two breast cancer patients. The treatment volumes were the entire breasts (218 cc and 1500 cc) prescribed to 50.4 Gy (RBE) in 28 fractions. A range shifter of 5 cm water equivalent thickness was used. The organ at risk (skin) was defined to be 5 mm thick from the surface...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046677/su-f-t-218-validation-of-an-in-vivo-proton-range-verification-method-for-reducing-the-risk-of-permanent-alopecia-in-the-treatment-of-pediatric-medulloblastoma
#14
G Lucconi, E Bentefour, S Deepak, G Janssens, K Weaver, M Moteabbed, H-M Lu
PURPOSE: The clinical commissioning of a workflow for pre-treatment range verification/adjustment for the head treatment of pediatric medulloblastoma patients, including dose monitoring during treatment. METHODS: An array of Si-diodes (DIODES Incorporated) is placed on the patient skin on the opposite side to the beam entrance. A "scout" SOBP beam, with a longer beam range to cover the diodes in its plateau, is delivered; the measured signal is analyzed and the extracted water equivalent path lengths (WEPL) are compared to the expected values, revealing if a range correction is needed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046290/su-f-t-517-determining-the-tissue-equivalence-of-a-brass-mesh-bolus-in-a-reconstructed-chest-wall-irradiation
#15
E Shekel, D Epstein, D Levin
PURPOSE: To determine the tissue equivalence of a brass mesh bolus (RPD) in the setting of a reconstructed chest wall irradiation METHODS: We measured breast skin dose delivered by a tangential field plan on an anthropomorphic phantom using Mosfet and nanoDot (Landauer) dosimeters in five different locations on the breast. We also measured skin dose using no bolus, 5mm and 10 mm superflab bolus. In the Eclipse treatment planning system (Varian, Palo Alto, CA) we calculated skin dose for different bolus thicknesses, ranging from 0 to 10 mm, in order to evaluate which calculation best matches the brass mesh measurements, as the brass mesh cannot be simulated due to artefacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044470/gold-nanoparticles-as-dose-enhancement-agent-for-kilovoltage-x-ray-therapy-of-melanoma
#16
So-Ra Kim, Eun-Hee Kim
PURPOSE: Melanoma is mainly treated by surgery and rarely with radiation because of the high radio-resistance of this tumor. Nevertheless, radiotherapy is the preferred treatment modality for unresectable lesions and avoiding cosmetic disfigurement caused by surgical excision. This study investigated the therapeutic advantage of gold nanoparticles (AuNPs) for kilovoltage X-ray treatment of melanoma. MATERIALS AND METHODS: Commercial AuNPs were evaluated for cytotoxicity and cellular internalization...
January 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28039188/abnormal-joint-and-bone-wound-healing-in-hemophilia-mice-is-improved-by-extending-factor-ix-activity-after-hemarthrosis
#17
Junjiang Sun, Baolai Hua, Eric W Livingston, Sarah Taves, Peter B Johansen, Maureane Hoffman, Mirella Ezban, Dougald M Monroe, Ted A Bateman, Paul E Monahan
Wound healing requires interactions between coagulation, inflammation, angiogenesis, cellular migration, and proliferation. Healing in dermal wounds of hemophilia B mice is delayed when compared to hemostatically normal wild type (WT) mice, with abnormal persistence of iron deposition, inflammation, and neovascularity. We observed healing following induced joint hemorrhage in WT and factor IX (FIX) knockout (FIX(-/-)) mice, examining also parameters previously studied in an excisional skin wound model. Hemostatically normal mice tolerated this joint bleeding challenge, cleared blood from the joint, and healed with minimal pathology, even if additional autologous blood was injected intra-articularly at the time of wounding...
December 30, 2016: Blood
https://www.readbyqxmd.com/read/28033194/neonatal-soft-tissue-reconstruction-using-a-bioengineered-skin-substitute
#18
Scott D Hirsch, Jeremy M Powers, Jennifer L Rhodes
Total parenteral nutrition (TPN) can be a lifesaving intervention for premature neonates and it is often delivered through peripheral access in this unique population. However, extravasation and tissue damage can result. Current literature lacks strong evidence regarding the treatment and reconstruction of such injuries in this age group. The authors present a patient with a 30-week gestational age premature newborn whom suffered an extravasation injury with peripherally administered TPN leading to full thickness skin and soft tissue necrosis of the dorsum of the right hand...
December 28, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28029227/physicochemical-antioxidant-and-cytotoxic-properties-of-xao-tam-phan-paramignya-trimera-root-extract-and-its-fractions
#19
Nguyen Van Tang, Jennette A Sakoff, Christopher J Scarlett
Xao tam phan (Paramignya trimera (Oliv.) Guillaum) has been used as a medicinal plant for cancer prevention and treatment in recent years. The objective of this study was to determine the physicochemical, antioxidant and cytotoxic properties of crude P. trimera root (PTR) extract and its fractions using methanol as a solvent and microwave-assisted extraction as an advanced technique for preparation of the PTR extract. The results showed that the PTR extract had high contents of saponins, phenolics, flavonoids and proanthocyanidins (7731...
December 28, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28027893/correction-of-recessive-dystrophic-epidermolysis-bullosa-by-transposon-mediated-integration-of-col7a1-in-transplantable-patient-derived-primary-keratinocytes
#20
Maria Carmela Latella, Fabienne Cocchiarella, Laura De Rosa, Giandomenico Turchiano, Manuel A F V Gonçalves, Fernando Larcher, Michele De Luca, Alessandra Recchia
Recessive dystrophic epidermolysis bullosa (RDEB) is caused by defects in type-VII collagen (C7), a protein encoded by the COL7A1 gene and essential for anchoring fibril formation at the dermal-epidermal junction. Gene therapy of RDEB is based on transplantation of autologous epidermal grafts generated from gene-corrected keratinocytes sustaining C7 deposition at the dermal-epidermal junction. Transfer of the COL7A1 gene is complicated by its very large size and repetitive sequence. We report a gene delivery approach based on the Sleeping beauty transposon, which allows integration of a full-length COL7A1 cDNA and secretion of C7 at physiological levels in RDEB keratinocytes without rearrangements or detrimental effects on their clonogenic potential...
December 24, 2016: Journal of Investigative Dermatology
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