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https://www.readbyqxmd.com/read/28930588/nanoparticles-in-wound-healing-from-hope-to-promise-from-promise-to-routine
#1
Naghmeh Naderi, Dimitrios Karponis, Afshin Mosahebi, Alexander M Seifalian
Chronic non-healing wounds represent a growing problem due to their high morbidity and cost. Despite recent advances in wound healing, several systemic and local factors can disrupt the weighed physiologic healing process. This paper critically reviews and discusses the role of nanotechnology in promoting the wound healing process. Nanotechnology-based materials have physicochemical, optical and biological properties unique from their bulk equivalent. These nanoparticles can be incorporated into scaffolds to create nanocomposite smart materials, which promote wound healing through their antimicrobial, as well as selective anti- and pro-inflammatory, and pro-angiogenic properties...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930257/physicochemical-properties-antioxidant-and-cytotoxic-activities-of-crude-extracts-and-fractions-from-phyllanthus-amarus
#2
Van Tang Nguyen, Jennette A Sakoff, Christopher J Scarlett
Background:Phyllanthus amarus (P. amarus) has been used as a medicinal plant for the prevention and treatment of chronic ailments such as diabetes, hepatitis, and cancer. Methods: The physicochemical properties, antioxidant and cytotoxic activities of crude extracts and fractions from P. amarus were determined using spectrophotometric method. Results: The P. amarus methanol (PAM) extract had lower levels of residual moisture (7.40%) and water activity (0.24) and higher contents of saponins, phenolics, flavonoids, and proanthocyanidins (1657...
June 18, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28928444/immortalized-n-tert-keratinocytes-as-an-alternative-cell-source-in-3d-human-epidermal-models
#3
Jos P H Smits, Hanna Niehues, Gijs Rikken, Ivonne M J J van Vlijmen-Willems, Guillaume W H J F van de Zande, Patrick L J M Zeeuwen, Joost Schalkwijk, Ellen H van den Bogaard
The strong societal urge to reduce the use of experimental animals, and the biological differences between rodent and human skin, have led to the development of alternative models for healthy and diseased human skin. However, the limited availability of primary keratinocytes to generate such models hampers large-scale implementation of skin models in biomedical, toxicological, and pharmaceutical research. Immortalized cell lines may overcome these issues, however, few immortalized human keratinocyte cell lines are available and most do not form a fully stratified epithelium...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922523/mature-b-cells-accelerate-wound-healing-after-acute-and-chronic-diabetic-skin-lesions
#4
Ruxandra F Sîrbulescu, Chloe K Boehm, Erin Soon, Moses Q Wilks, Iulian Ilieş, Hushan Yuan, Ben Maxner, Nicolas Chronos, Charalambos Kaittanis, Marc D Normandin, Georges El Fakhri, Dennis P Orgill, Ann E Sluder, Mark C Poznansky
Chronic wounds affect 12-15% of patients with diabetes and are associated with a drastic decrease in their quality of life. Here we demonstrate that purified mature naïve B220(+) /CD19(+) /IgM(+) /IgD(+) B cells improve healing of acute and diabetic murine wounds after a single topical application. B cell treatment significantly accelerated acute wound closure by 2-3 days in wild-type mice and 5-6 days in obese diabetic mice. The treatment led to full closure in 43% of chronic diabetic wounds, as compared to only 5% in saline-treated controls...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28921404/effectiveness-of-a-new-lead-shielding-device-and-additional-filter-for-reducing-staff-and-patient-radiation-exposure-during-videofluoroscopic-swallowing-study-using-a-human-phantom
#5
Yoshiaki Morishima, Koichi Chida, Yoshikazu Muroya, Yoshiya Utsumi
Interventional radiology procedures often involve lengthy exposure to fluoroscopy-derived radiation. We therefore devised a videofluoroscopic swallowing study (VFSS) procedure using a human phantom that proved to protect the patient and physician by reducing the radiation dose. We evaluated a new lead-shielding device and separately attached additional filters (1.0-, 2.0-, and 3.0-mm Al filters and a 0.5-mm Cu filter) during VFSS to reduce the patient's entrance skin dose (ESD). A monitor attached to the human phantom's neck measured the ESD...
September 18, 2017: Dysphagia
https://www.readbyqxmd.com/read/28906033/collagen-peptides-modulates-the-metabolism-of-extracellular-matrix-by-human-dermal-fibroblasts-derived-from-sun-protected-and-sun-exposed-body-sites
#6
Vivian Zague, Jonatas Bussador do Amaral, Paula Rezende Teixeira, Evandro Luis de Oliveira Niero, Camila Lauand, Glaucia Maria Machado-Santelli
Clinical data published in recent years has demonstrated positive effects of collagen hydrolysate (CH) on skin aging clinical signs. CH use as food supplement has a long history; however, few studies have addressed the underlying purpose of CH on the cellular and molecular biology of skin cells that could elucidate clinical improvement findings. Wide diversity of characteristics has been reported for dermal fibroblasts derived from different body sites and it is unknown whether collagen peptides could modulate differently cells from chronological aged and photoaged skin areas...
September 14, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28890854/quantitative-comparison-of-the-spreading-and-invasion-of-radial-growth-phase-and-metastatic-melanoma-cells-in-a-three-dimensional-human-skin-equivalent-model
#7
Parvathi Haridas, Jacqui A McGovern, Sean D L McElwain, Matthew J Simpson
BACKGROUND: Standard two-dimensional (2D) cell migration assays do not provide information about vertical invasion processes, which are critical for melanoma progression. We provide information about three-dimensional (3D) melanoma cell migration, proliferation and invasion in a 3D melanoma skin equivalent (MSE) model. In particular, we pay careful attention to compare the structure of the tissues in the MSE with similarly-prepared 3D human skin equivalent (HSE) models. The HSE model is identically prepared to the MSE model except that melanoma cells are omitted...
2017: PeerJ
https://www.readbyqxmd.com/read/28871993/predicted-rate-of-secondary-malignancies-following-adjuvant-proton-versus-photon-radiation-therapy-for-thymoma
#8
J Vogel, L Lin, L A Litzky, A T Berman, C B Simone
PURPOSE: Thymic malignancies are the most common tumors of the anterior mediastinum. The benefit of adjuvant radiation therapy for stage II disease remains controversial, and patients treated with adjuvant radiation therapy are at risk of late complications, including radiation-induced secondary malignant neoplasms (SMNs), that may reduce the overall benefit of treatment. We assess the risk of predicted SMNs following adjuvant proton radiation therapy compared with photon radiation therapy after resection of stage II thymic malignancies to determine whether proton therapy improves the risk-benefit ratio...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28869278/cerebral-near-infrared-spectroscopy-monitoring-for-prevention-of-brain-injury-in-very-preterm-infants
#9
REVIEW
Simon Hyttel-Sorensen, Gorm Greisen, Bodil Als-Nielsen, Christian Gluud
BACKGROUND: Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants. Cerebral near-infrared spectroscopy (NIRS) enables continuous estimation of cerebral oxygenation. This diagnostic method coupled with appropriate interventions if NIRS is out of normal range (that is cerebral oxygenation within the 55% to 85% range) may offer benefits without causing more harms. Therefore, NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of randomised clinical trials and quasi-randomised studies...
September 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28867907/preemptive-analgesia-in-thumb-basal-joint-arthroplasty-immediate-postoperative-pain-with-preincision-versus-postincision-local-anesthesia
#10
Joseph T Labrum, Asif M Ilyas
Purpose  Currently no guidelines exist for the timing of the injection of anesthetics in surgeries performed under general anesthesia to minimize postoperative pain. To better understand the role of timing of the injection of local anesthesia in hand surgery performed under general anesthesia, we evaluated the effect of pre- versus postincisional local analgesic injection on immediate postoperative pain experience. We hypothesize that the preincisional (preemptive) injection will result in decreased immediate postoperative pain experience and analgesic use when compared with postincisional injection...
August 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/28858661/skin-permeability-and-transdermal-delivery-route-of-50-nm-indomethacin-loaded-plga-nanoparticles
#11
Issei Takeuchi, Takaaki Suzuki, Kimiko Makino
Recently, nano-seized systems for transdermal delivery have attracted attention. To efficiently deliver drugs to hair follicles, we focused on poly(DL-lactide-co-glycolide) (PLGA) nanoparticles prepared using a combination of an antisolvent diffusion method with preferential solvation. The PLGA nanoparticles prepared using this method are suitable for iontophoresis because of their high surface charge number density. It has been reported that PLGA nanoparticles were delivered to hair follicles by applying iontophoresis, however research on PLGA nanoparticles with a size of less than 100nm was lacking...
August 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28857089/-ercp-procedures-as-a-source-of-radiation-risk-to-a-single-gastroenterologist
#12
Maria A Staniszewska, Krzysztof Kujawski, Renata Kopeć, Krzysztof Sasak
BACKGROUND: One of the numerous sub-areas of interventional radiology is the use of X-rays in gastroenterology. X-ray fluoroscopy is applied in therapeutic procedures, including endoscopic retrograde cholangiopancreatography (ERCP) that is frequently performed. The ERCP procedure is aimed at imaging the pancreatic duct and biliary tracts. MATERIAL AND METHODS: In this paper radiation risk to the gastrenterologist performing ERCP procedures was investigated. The procedures were performed by a single gastroenterologist in the ERCP Laboratory, University Clinical Hospital Military Memorial Medical Academy - Central Veterans' Hospital in Łódź, Poland...
August 31, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28845295/apoptotic-resistance-of-human-skin-mast-cells-is-mediated-by-mcl-1
#13
Tarek Hazzan, Jürgen Eberle, Margitta Worm, Magda Babina
Mast cells (MCs) are major effector cells of allergic reactions and contribute to multiple other pathophysiological processes. MCs are long-lived in the tissue microenvironment, in which they matured, but it remains ill-defined how longevity is established by the natural habitat, as research on human MCs chiefly employs cells generated and expanded in culture. In this study, we report that naturally differentiated skin MCs exhibit substantial resilience to cell death with considerable portions surviving up to 3 days in the complete absence of growth factors (GF)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28843727/hypofractionated-radiation-therapy-for-basal-and-squamous-cell-skin-cancer-a-meta-analysis
#14
Nicholas G Zaorsky, Charles T Lee, Eddie Zhang, Scott W Keith, Thomas J Galloway
PURPOSE: To characterize the cosmetic outcomes and local recurrence (LR) rates of various hypofractionated radiation therapy (RT) regimens for skin basal and squamous cell cancers (BCCs/SCCs). METHODS: A PICOS/PRISMA/MOOSE selection protocol was performed to identify 344 articles published between 1985-2016 evaluating patients with T1-2 N0 SCCs/BCCs treated with definitive RT. Biologically equivalent doses with α/β=3 (BED3s) were calculated. The primary endpoint was post-treatment cosmesis...
August 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28842374/immobilization-of-bacteriophage-in-wound-dressing-nanostructure
#15
Frederico Nogueira, Natia Karumidze, Ia Kusradze, Marina Goderdzishvili, Pilar Teixeira, Isabel C Gouveia
Opportunistic bacteria that cause life-threatening infections are still a central problem associated with a healthcare setting. Bacteriophage capsid immobilization on nanostructured polymers maximizes its tail exposure and looks promising in applications toward skin-infections as alternative to antibiotics standardly used. The main goal of this work was to investigate the covalent immobilization of vB_Pae_Kakheti25 bacteriophage capsid on polycaprolactone (PCL) nanofibers (non-woven textile), as a potential effective antimicrobial, laundry resistant and non-toxic dressing for biomedical use...
August 25, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28835332/prospective-observational-study-to-assess-the-need-for-postoperative-antibiotics-following-surgical-incision-and-drainage-of-skin-and-soft-tissue-abscess-in-pediatric-patients
#16
Ian C Glenn, Nicholas E Bruns, Oliver S Soldes, Todd A Ponsky
BACKGROUND: Post-operative antibiotics are often utilized for skin and soft tissue infection (SSTI) requiring surgical incision and drainage (I&D). We propose that antibiotics are unnecessary following I&D. METHODS: Patients aged 3months to 6years with SSTI of the buttocks, groin, thigh, and/or labia requiring I&D were prospectively enrolled. The primary outcome was the proportion of patients requiring re-drainage and/or antibiotics for SSTI recurrence, within 30days...
August 7, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28831678/evaluation-of-allergic-sensitization-in-lebanese-patients-with-allergic-conjunctivitis
#17
Nicolas Arej, Carla Irani, Youssef Abdelmassih, Elise Slim, Joelle Antoun, Riad Bejjani, Alexandre Schakal, Naji Waked
PURPOSE: To describe the profile of patients with allergic conjunctivitis (AC) regarding their demographics, symptomatology and specific allergen sensitization, in a Lebanese tertiary hospital. METHODS: Cross-sectional study conducted at the Hôtel-Dieu de France hospital (Beirut, Lebanon) during a period of 18 months. Patients with seasonal or perennial AC presenting for ophthalmic consultation had measurements of total and specific IgE. A matching group of patients with AC seen at the allergist office during the same period underwent skin prick tests (SPTs)...
August 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28817649/point-of-care-wound-visioning-technology-reproducibility-and-accuracy-of-a-wound-measurement-app
#18
Sheila C Wang, John A E Anderson, Robyn Evans, Kevin Woo, Benjamin Beland, Denis Sasseville, Linda Moreau
BACKGROUND: Current wound assessment practices are lacking on several measures. For example, the most common method for measuring wound size is using a ruler, which has been demonstrated to be crude and inaccurate. An increase in periwound temperature is a classic sign of infection but skin temperature is not always measured during wound assessments. To address this, we have developed a smartphone application that enables non-contact wound surface area and temperature measurements. Here we evaluate the inter-rater reliability and accuracy of this novel point-of-care wound assessment tool...
2017: PloS One
https://www.readbyqxmd.com/read/28806596/development-of-an-effective-dose-coefficient-database-using-a-computational-human-phantom-and-monte-carlo-simulations-to-evaluate-exposure-dose-for-the-usage-of-norm-added-consumer-products
#19
Do Hyeon Yoo, Wook-Geun Shin, Jaekook Lee, Yeon Soo Yeom, Chan Hyeong Kim, Byung-Uck Chang, Chul Hee Min
After the Fukushima accident in Japan, the Korean Government implemented the "Act on Protective Action Guidelines Against Radiation in the Natural Environment" to regulate unnecessary radiation exposure to the public. However, despite the law which came into effect in July 2012, an appropriate method to evaluate the equivalent and effective doses from naturally occurring radioactive material (NORM) in consumer products is not available. The aim of the present study is to develop and validate an effective dose coefficient database enabling the simple and correct evaluation of the effective dose due to the usage of NORM-added consumer products...
August 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28805336/matrix-stimulation-in-cancer-pain-methodology-safety-and-effectiveness
#20
M Mücke, M Tils, R Conrad, D Kravchenko, H Cuhls, L Radbruch, M Marinova, V Peuckmann-Post, R Rolke
BACKGROUND: This feasibility study addresses the applicability of matrix electrodes for the reduction of ongoing pain in cancer patients via low-frequency electrical stimulation (LFS). METHODS: Low-frequency matrix stimulation (4 Hz) was applied to the skin within the 'Head's zones' referring to the tumour localization of cancer pain patients. Pain at baseline was compared to a 3-day treatment interval consisting of 5 min of matrix stimulation in the morning and evening followed by a 3-day follow-up period without therapy...
August 14, 2017: European Journal of Pain: EJP
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