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https://www.readbyqxmd.com/read/28817649/point-of-care-wound-visioning-technology-reproducibility-and-accuracy-of-a-wound-measurement-app
#1
Sheila C Wang, John A E Anderson, Robyn Evans, Kevin Woo, Benjamin Beland, Denis Sasseville, Linda Moreau
BACKGROUND: Current wound assessment practices are lacking on several measures. For example, the most common method for measuring wound size is using a ruler, which has been demonstrated to be crude and inaccurate. An increase in periwound temperature is a classic sign of infection but skin temperature is not always measured during wound assessments. To address this, we have developed a smartphone application that enables non-contact wound surface area and temperature measurements. Here we evaluate the inter-rater reliability and accuracy of this novel point-of-care wound assessment tool...
2017: PloS One
https://www.readbyqxmd.com/read/28806596/development-of-an-effective-dose-coefficient-database-using-a-computational-human-phantom-and-monte-carlo-simulations-to-evaluate-exposure-dose-for-the-usage-of-norm-added-consumer-products
#2
Do Hyeon Yoo, Wook-Geun Shin, Jaekook Lee, Yeon Soo Yeom, Chan Hyeong Kim, Byung-Uck Chang, Chul Hee Min
After the Fukushima accident in Japan, the Korean Government implemented the "Act on Protective Action Guidelines Against Radiation in the Natural Environment" to regulate unnecessary radiation exposure to the public. However, despite the law which came into effect in July 2012, an appropriate method to evaluate the equivalent and effective doses from naturally occurring radioactive material (NORM) in consumer products is not available. The aim of the present study is to develop and validate an effective dose coefficient database enabling the simple and correct evaluation of the effective dose due to the usage of NORM-added consumer products...
August 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28805336/matrix-stimulation-in-cancer-pain-methodology-safety-and-effectiveness
#3
M Mücke, M Tils, R Conrad, D Kravchenko, H Cuhls, L Radbruch, M Marinova, V Peuckmann-Post, R Rolke
BACKGROUND: This feasibility study addresses the applicability of matrix electrodes for the reduction of ongoing pain in cancer patients via low-frequency electrical stimulation (LFS). METHODS: Low-frequency matrix stimulation (4 Hz) was applied to the skin within the 'Head's zones' referring to the tumour localization of cancer pain patients. Pain at baseline was compared to a 3-day treatment interval consisting of 5 min of matrix stimulation in the morning and evening followed by a 3-day follow-up period without therapy...
August 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28801749/cancer-risk-assessment-of-polycyclic-aromatic-hydrocarbons-in-the-soils-and-sediments-of-india-a-meta-analysis
#4
Abhrajyoti Tarafdar, Alok Sinha
A carcinogenic risk assessment of polycyclic aromatic hydrocarbons in soils and sediments was conducted using the probabilistic approach from a national perspective. Published monitoring data of polycyclic aromatic hydrocarbons present in soils and sediments at different study points across India were collected and converted to their corresponding BaP equivalent concentrations. These BaP equivalent concentrations were used to evaluate comprehensive cancer risk for two different age groups. Monte Carlo simulation and sensitivity analysis were applied to quantify uncertainties of risk estimation...
August 11, 2017: Environmental Management
https://www.readbyqxmd.com/read/28800953/col7a1-editing-via-crispr-cas9-in-recessive-dystrophic-epidermolysis-bullosa
#5
Stefan Hainzl, Patricia Peking, Thomas Kocher, Eva M Murauer, Fernando Larcher, Marcela Del Rio, Blanca Duarte, Markus Steiner, Alfred Klausegger, Johann W Bauer, Julia Reichelt, Ulrich Koller
Designer nucleases allow specific and precise genomic modifications and represent versatile molecular tools for the correction of disease-associated mutations. In this study, we have exploited an ex vivo CRISPR/Cas9-mediated homology-directed repair approach for the correction of a frequent inherited mutation in exon 80 of COL7A1, which impairs type VII collagen expression, causing the severe blistering skin disease recessive dystrophic epidermolysis bullosa. Upon CRISPR/Cas9 treatment of patient-derived keratinocytes, using either the wild-type Cas9 or D10A nickase, corrected single-cell clones expressed and secreted similar levels of type VII collagen as control keratinocytes...
July 13, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28791291/atopic-dermatitis-studies-through-in-vitro-models
#6
REVIEW
Evelyne De Vuyst, Michel Salmon, Céline Evrard, Catherine Lambert de Rouvroit, Yves Poumay
Atopic dermatitis (AD) is a complex inflammatory skin condition that is not fully understood. Epidermal barrier defects and Th2 immune response dysregulations are thought to play crucial roles in the pathogenesis of the disease. A vicious circle takes place between these alterations, and it can further be complicated by additional genetic and environmental factors. Studies investigating in more depth the etiology of the disease are thus needed in order to develop functional treatments. In recent years, there have been significant advances regarding in vitro models reproducing important features of AD...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28789775/cardiorespiratory-fitness-and-cancer-incidence-in-men
#7
Baruch Vainshelboim, Jan Müller, Ricardo M Lima, Kevin T Nead, Cariad Chester, Khin Chan, Peter Kokkinos, Jonathan Myers
PURPOSE: The preventive role of cardiorespiratory fitness (CRF) in cancer is not well established. The present study sought to evaluate the association between CRF and cancer incidence in men. METHODS: Maximal exercise testing was performed in 4920 men (59.2 ± 11.4 years) free from malignancy at baseline who were followed for 12.7 ± 7.5 years. Relative risks and population attributable risks were determined. RESULTS: During the follow-up, 25...
July 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28777946/engineered-epidermal-progenitor-cells-can-correct-diet-induced-obesity-and-diabetes
#8
Jiping Yue, Xuewen Gou, Yuanyuan Li, Barton Wicksteed, Xiaoyang Wu
Somatic gene therapy is a promising approach for treating otherwise terminal or debilitating diseases. The human skin is a promising conduit for genetic engineering, as it is the largest and most accessible organ, epidermal autografts and tissue-engineered skin equivalents have been successfully deployed in clinical applications, and skin epidermal stem/progenitor cells for generating such grafts are easy to obtain and expand in vitro. Here, we develop skin grafts from mouse and human epidermal progenitors that were engineered by CRISPR-mediated genome editing to controllably release GLP-1 (glucagon-like peptide 1), a critical incretin that regulates blood glucose homeostasis...
August 3, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28776197/long-term-exposure-of-immortalized-keratinocytes-to-arsenic-induces-emt-impairs-differentiation-in-organotypic-skin-models-and-mimics-aspects-of-human-skin-derangements
#9
R Weinmuellner, K Kryeziu, B Zbiral, K Tav, B Schoenhacker-Alte, D Groza, L Wimmer, M Schosserer, F Nagelreiter, S Rösinger, M Mildner, E Tschachler, M Grusch, J Grillari, P Heffeter
Arsenic is one of the most important human carcinogens and environmental pollutants. However, the evaluation of the underlying carcinogenic mechanisms is challenging due to the lack of suitable in vivo and in vitro models, as distinct interspecies differences in arsenic metabolism exist. Thus, it is of high interest to develop new experimental models of arsenic-induced skin tumorigenesis in humans. Consequently, aim of this study was to establish an advanced 3D model for the investigation of arsenic-induced skin derangements, namely skin equivalents, built from immortalized human keratinocytes (NHEK/SVTERT3-5)...
August 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28774590/human-adipose-mesenchymal-cells-inhibit-melanocyte-differentiation-and-the-pigmentation-of-human-skin-via-increased-expression-of-tgf-%C3%AE-1
#10
Agnes S Klar, Thomas Biedermann, Katarzyna Michalak, Teresa Michalczyk, Claudia Meuli-Simmen, Arnaud Scherberich, Martin Meuli, Ernst Reichmann
There is accumulating evidence that interactions between epidermal melanocytes and stromal cells play an important role in the regulation of skin pigmentation. In this study we established a pigmented dermo-epidermal skin model (melDESS) of human origin to investigate the effects of distinct stromal cells on melanogenesis. melDESS is a complex, clinically relevant skin equivalent composed of an epidermis containing both melanocytes and keratinocytes. Its dermal compartment consisted either of adipose tissue-derived stromal cells (ASC), dermal fibroblasts, or a mixture of both cell types...
July 31, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28769106/lipoxin-a4-and-its-analog-suppress-inflammation-by-modulating-hmgb1-translocation-and-expression-in-psoriasis
#11
Xinxin Liu, Xin Wang, Xiaoru Duan, Devesh Poorun, Juntao Xu, Song Zhang, Lu Gan, Mengwen He, Ke Zhu, Zhangyin Ming, Feng Hu, Hongxiang Chen
Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population, and there is still no known possibility of a cure. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. BML-111 (5(S)-6(R)-7-trihydroxyheptanoic acid methyl ester), a lipoxin receptor agonist, has been previously confirmed to be equivalent to LXA4 in the anti-inflammatory processes. High mobility group box 1 (HMGB1) serves as an inflammatory cytokine when secreted extracellularly in psoriatic lesions and is involved in the development of psoriasis...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764071/determination-of-total-iron-reactive-phenolics-anthocyanins-and-tannins-in-wine-grapes-of-skins-and-seeds-based-on-near-infrared-hyperspectral-imaging
#12
Ni Zhang, Xu Liu, Xiaoduo Jin, Chen Li, Xuan Wu, Shuqin Yang, Jifeng Ning, Paul Yanne
Phenolics contents in wine grapes are key indicators for assessing ripeness. Near-infrared hyperspectral images during ripening have been explored to achieve an effective method for predicting phenolics contents. Principal component regression (PCR), partial least squares regression (PLSR) and support vector regression (SVR) models were built, respectively. The results show that SVR behaves globally better than PLSR and PCR, except in predicting tannins content of seeds. For the best prediction results, the squared correlation coefficient and root mean square error reached 0...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28763290/powered-air-purifying-respirator-use-in-healthcare-effects-on-thermal-sensations-and-comfort
#13
Jeffrey B Powell, Jung-Hyun Kim, Raymond J Roberge
Twelve subjects wore an N95 filtering facepiece respirator (N95 FFR), one tight-fitting full facepiece powered air-purifying respirator (PAPR), two loose-fitting PAPRs, and one elastomeric/PAPR hybrid for 1 hr each during treadmill walking at 5.6 km/h while undergoing physiological and subjective response monitoring. No significant interaction (p≥.05) was noted between the five respirators in heart rate, respiratory rate, oxygen saturation, transcutaneous carbon dioxide, and perceptions of breathing effort or discomfort, exertion, facial heat, and overall body heat...
August 1, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28761716/prevalence-of-laceration-injuries-in-professional-and-amateur-rugby-union-a-systematic-review-and-meta-analysis
#14
REVIEW
Bodil Yucki Oudshoorn, Heather Driscoll, Karen Kilner, Marcus Dunn, David James
BACKGROUND: Studded footwear can cause severe lacerations in rugby union; the prevalence of these injuries is currently unknown. OBJECTIVE: To summarise the skin and laceration injury prevalence in published epidemiological studies and to investigate any differences in skin injury risk between amateur and professional players. DESIGN: Systematic literature review and meta-analysis of epidemiological studies. DATA SOURCES: PubMed, Web of Science, Scopus and Ovid...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28760036/tubular-microdiscectomy-techniques-complication-avoidance-and-review-of-the-literature
#15
Aaron J Clark, Michael M Safaee, Nickalus R Khan, Matthew T Brown, Kevin T Foley
OBJECTIVE Microendoscopic discectomy is a minimally invasive surgery technique that was initially described in 1997. It allows surgeons to work with 2 hands through a small-diameter, operating table-mounted tubular retractor, and to apply standard microsurgical techniques in which a small skin incision and minimal muscle dissection are used. Whether the surgeon chooses to use an endoscope or a microscope for visualization, the technique uses the same type of retractor and is thus called tubular microdiscectomy...
August 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28752668/comparison-of-two-decellularized-dermal-equivalents
#16
Shiuhyang Kuo, Hyungjin Myra Kim, Zhifa Wang, Eve L Bingham, Atsuko Miyazawa, Cynthia L Marcelo, Stephen E Feinberg
Immunologically inert allogeneic acellular dermal scaffolds provide a matrix with molecular architecture close to native tissues, which synthetic scaffolds cannot. Not all nature-derived scaffolds possess the same biological and physical properties. The different properties of scaffolds supporting cellular growth used for manufacturing tissue engineered grafts could lead to different implantation results. The scaffold properties should be carefully considered in order to meet the expected outcomes of tissue engineered grafts...
July 28, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28749618/radiation-induced-second-cancer-risk-from-external-beam-photon-radiotherapy-for-head-and-neck-cancer-impact-on-in-field-and-out-of-field-organs
#17
Vasanthan Sakthivel, Ganesh Kadirampatti Mani, Sunil Mani, Raghavendiran Boopathy
The purpose of this paper is to provide data on development of second primary cancers within or adjacent to tissue irradiated in the treatment of primary head and neck cancers using different techniques and modalities. Materials and methods: We selected five patients with HandN tumors located in base of the tongue for risk assessment. In order to examine the impact of choices of various planning techniques, numbers of beams and beam energy used in treatment plans - 7 and 9 field Intensity modulated radiotherapy (IMRT) plans using 6MV and 10 MV beam energies and a 6MV Volumetric modulated arc therapy (VMAT) plans were planned...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28748829/dose-assessment-following-an-overexposure-of-a-worker-at-a-swiss-nuclear-power-plant
#18
Claude J Bailat, Jean-Pascal Laedermann, Sebastien Baechler, Laurent Desorgher, Abbas Aroua, Francois O Bochud
AIM: The aim of this work was to assess the doses received by a diver exposed to a radiation source during maintenance work in the fuel transfer pool at a Swiss nuclear power plant, and to define whether the statutory limit was breached or not. METHOD: Onsite measurements were carried out and different scenarios were simulated using the MicroShield Software and the MCNPX Monte Carlo (MC) radiation transport code to estimate the activity of the irradiating object as well as the doses to the limbs and the effective dose delivered to the operator...
July 27, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28740328/assessment-of-equivalence-of-adipose-tissue-treatment-with-a-noncontact-field-rf-system-delivering-200-w-for-30-min-and-300-w-for-20-min-an-in-vivo-porcine-study
#19
Tae-Rin Kwon, Jong Hwan Kim, Seok Joon, Seok Kyun Mun, Chan Woong Kim, Beom Joon Kim
BACKGROUND AND AIMS: Abdominal circumferential reduction with noncontact high frequency apoptosis-inducing field RF (AiRF) is becoming very popular. The present study compared the treatment results from two different sets of parameters giving the same dose from the same system in an in vivo porcine model. MATERIALS AND METHODS: Two 10 cm × 10 cm areas were symmetrically marked on both sides of the midline (total of 4 areas) over the rectus abdominis muscle of two anesthetized female micropigs...
March 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/28736669/photoacoustic-reflection-artifact-reduction-using-photoacoustic-guided-focused-ultrasound-comparison-between-plane-wave-and-element-by-element-synthetic-backpropagation-approach
#20
Mithun Kuniyil Ajith Singh, Michael Jaeger, Martin Frenz, Wiendelt Steenbergen
Reflection artifacts caused by acoustic inhomogeneities constitute a major problem in epi-mode biomedical photoacoustic imaging. Photoacoustic transients from the skin and superficial optical absorbers traverse into the tissue and reflect off echogenic structures to generate reflection artifacts. These artifacts cause difficulties in the interpretation of images and reduce contrast and imaging depth. We recently developed a method called PAFUSion (photoacoustic-guided focused ultrasound) to circumvent the problem of reflection artifacts in photoacoustic imaging...
April 1, 2017: Biomedical Optics Express
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