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Lewy bodies dementia

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https://www.readbyqxmd.com/read/29686602/advancing-stem-cell-models-of-alpha-synuclein-gene-regulation-in-neurodegenerative-disease
#1
REVIEW
Desiree A Piper, Danuta Sastre, Birgitt Schüle
Alpha-synuclein ( non A4 component of amyloid precursor, SNCA, NM_000345.3 ) plays a central role in the pathogenesis of Parkinson's disease (PD) and related Lewy body disorders such as Parkinson's disease dementia, Lewy body dementia, and multiple system atrophy. Since its discovery as a disease-causing gene in 1997, alpha-synuclein has been a central point of scientific interest both at the protein and gene level. Mutations, including copy number variants, missense mutations, short structural variants, and single nucleotide polymorphisms, can be causative for PD and affect conformational changes of the protein, can contribute to changes in expression of alpha-synuclein and its isoforms, and can influence regulation of temporal as well as spatial levels of alpha-synuclein in different tissues and cell types...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29684335/emergence-of-breath-testing-as-a-new-non-invasive-diagnostic-modality-for-neurodegenerative-diseases
#2
REVIEW
N Siva Subramaniam, C S Bawden, H Waldvogel, R M L Faull, G S Howarth, R G Snell
Neurodegenerative diseases (NDDs) are incapacitating disorders that result in progressive motor and cognitive impairment. These disease include Alzheimer's disease the most common cause of dementia, frontotemporal dementia, amyotrophic lateral sclerosis, dementia with Lewy bodies, Parkinson's, Huntington's, Friedreich's ataxia, and prion disease. Dementia causing NDDs impose a high social and economic burden on communities around the world. Rapid growth in knowledge regarding the pathogenic mechanisms and disease-associated biomarkers of these diseases in the past few decades have accelerated the development of new diagnostic methods and therapeutic opportunities...
April 20, 2018: Brain Research
https://www.readbyqxmd.com/read/29673784/visual-texture-agnosia-in-dementia-with-lewy-bodies-and-alzheimer-s-disease
#3
Yuka Oishi, Toru Imamura, Tatsuo Shimomura, Kyoko Suzuki
BACKGROUND: Neuroimaging and some clinical studies have reported that the ventral visual pathway is relevant for visual texture recognition. Although a variety of visual deficits have been reported in patients with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), visual material identification and texture recognition have not been thoroughly examined. OBJECTIVES: To investigate visual texture recognition in patients with AD and DLB and to clarify the relationship between visual texture recognition and various visuoperceptual functions...
March 27, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29672930/clinical-and-imaging-correlates-of-amyloid-deposition-in-dementia-with-lewy-bodies
#4
Paul C Donaghy, Michael J Firbank, Alan J Thomas, Jim Lloyd, George Petrides, Nicola Barnett, Kirsty Olsen, John T O'Brien
BACKGROUND: Amyloid deposition is common in dementia with Lewy bodies, but its pathophysiological significance is unclear. OBJECTIVE: The objective of this study was to investigate the relationship between amyloid deposition and clinical profile, gray matter volume, and brain perfusion in dementia with Lewy bodies. METHODS: Dementia with Lewy bodies (n = 37), Alzheimer's disease (n = 20), and controls (n = 20) underwent a thorough clinical assessment, 3T MRI, and early- and late-phase 18 F-Florbetapir PET-CT to assess cortical perfusion and amyloid deposition, respectively...
April 19, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29669601/potent-prion-like-behaviors-of-pathogenic-%C3%AE-synuclein-and-evaluation-of-inactivation-methods
#5
Airi Tarutani, Tetsuaki Arai, Shigeo Murayama, Shin-Ichi Hisanaga, Masato Hasegawa
The concept that abnormal protein aggregates show prion-like propagation between cells has been considered to explain the onset and progression of many neurodegenerative diseases. Indeed, both synthetic amyloid-like fibrils and pathogenic proteins extracted from patients' brains induce self-templated amplification and cell-to-cell transmission in vitro and in vivo. However, it is unclear whether exposure to exogenous prion-like proteins can potentially cause these diseases in humans. Here, we investigated in detail the prion-like seeding activities of several kinds of pathogenic α-synuclein (α-syn), including synthetic fibrils and detergent-insoluble fractions extracted from brains of patients with α-synucleinopathies...
April 18, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29667565/longitudinal-associations-between-different-dementia-diagnoses-and-medication-use-jointly-accounting-for-dropout
#6
George O Agogo, Christine M Ramsey, Danijela Gnjidic, Daniela C Moga, Heather Allore
ABSTRACTBackground:Longitudinal studies of older adults are characterized by high dropout rates, multimorbid conditions, and multiple medication use, especially proximal to death. We studied the association between multiple medication use and incident dementia diagnoses including Alzheimer's disease (AD), vascular dementia (VD), and Lewy-body dementia (LBD), simultaneously accounting for dropout. METHODS: Using the National Alzheimer's Coordinating Center data with three years of follow-up, a set of covariate-adjusted models that ignore dropout was fit to complete-case data, and to the whole-cohort data...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29665124/how-does-dementia-with-lewy-bodies-start-prodromal-cognitive-changes-in-rem-sleep-behavior-disorder
#7
Daphné Génier Marchand, Ronald B Postuma, Frédérique Escudier, Jessie De Roy, Amélie Pelletier, Jacques Montplaisir, Jean-François Gagnon
Objective We describe the progression of cognitive decline and identify the predictive values of cognitive tests in three groups of REM sleep behavior disorder (RBD) patients classified at their last follow-up as having Parkinson's disease (PD), dementia with Lewy bodies (DLB), or still-idiopathic. Methods Patients (n=109) underwent polysomnographic, neurological, and neuropsychological assessments. We used linear mixed-model analyses to compare the progression of cognitive test performance between the three groups over a three-year prodromal period, and performed linear regressions for a six-year prodromal period...
April 17, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29664058/relationships-between-rapid-eye-movement-sleep-behavior-disorder-and-neurodegenerative-diseases-clinical-assessments-biomarkers-and-treatment
#8
REVIEW
Min Li, Li Wang, Jiang-Hong Liu, Shu-Qin Zhan
Objective: Rapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and loss of muscle atonia during rapid eye movement sleep. RBD is closely related to α-synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Many studies have investigated the markers of imaging and neurophysiological, genetic, cognitive, autonomic function of RBD and their predictive value for neurodegenerative diseases. This report reviewed the progress of these studies and discussed their limitations and future research directions...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29662465/the-length-of-snca-rep1-microsatellite-may-influence-cognitive-evolution-in-parkinson-s-disease
#9
Lucia Corrado, Fabiola De Marchi, Sara Tunesi, Gaia Donata Oggioni, Miryam Carecchio, Luca Magistrelli, Silvana Tesei, Giulio Riboldazzi, Alessio Di Fonzo, Clarissa Locci, Ilaria Trezzi, Roberta Zangaglia, Cristina Cereda, Sandra D'Alfonso, Corrado Magnani, Giacomo P Comi, Giorgio Bono, Claudio Pacchetti, Roberto Cantello, Stefano Goldwurm, Cristoforo Comi
Background: Alpha-synuclein is a constituent of Lewy bodies and mutations of its gene cause familial Parkinson's disease (PD). A previous study showed that a variant of the alpha-synuclein gene ( SNCA ), namely the 263 bp allele of Rep1 was associated with faster motor progression in PD. On the contrary, a recent report failed to detect a detrimental effect of Rep1 263 on both motor and cognitive outcomes in PD. Aim of this study was to evaluate the influence of the Rep1 variants on disease progression in PD patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29661694/descriptive-epidemiology-of-parkinsonism-in-the-canton-of-geneva-switzerland
#10
Vanessa Fleury, Pauline Brindel, Nicolas Nicastro, Pierre R Burkhard
OBJECTIVES: A large descriptive cross-sectional population-based prevalence study as well as a retrospective incidence study were undertaken to ascertain the frequency of Parkinson's Disease (PD) and other types of degenerative and non-degenerative parkinsonism in the Canton of Geneva, Switzerland. METHODS: An extensive case-finding approach including records from public hospitals, private neurologists and nursing homes was utilized. All patients with a diagnosis of parkinsonism established between 2003 and 2012 were included...
April 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29658429/color-vision-impairment-differentiates-alzheimer-dementia-from-dementia-with-lewy-bodies
#11
Patrick M Flanigan, Mitra A Khosravi, James B Leverenz, Babak Tousi
OBJECTIVE: Dementia with Lewy bodies (DLB) is frequently misdiagnosed for Alzheimer dementia (AD), especially in its earlier stages. We characterized color vision impairment (CVI) in patients with DLB versus patients with AD to determine its usefulness in improving accuracy of early diagnosis. METHODS: We retrospectively reviewed charts of patients with AD, DLB, and patients with mild cognitive impairment suspected to be in the prodromal phase of DLB (pro-DLB) or prodromal phase of AD (pro-AD)...
March 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29657900/occipital-and-cingulate-hypometabolism-are-significantly-under-reported-on-18-fluorodeoxyglucose-positron-emission-tomography-scans-of-patients-with-lewy-body-dementia
#12
Moath Hamed, Frank Schraml, Jeffrey Wilson, James Galvin, Marwan N Sabbagh
Objective: To determine whether occipital and cingulate hypometabolism is being under-reported or missed on 18-fluorodeoxyglucose positron emission tomography (FDG-PET) CT scans in patients with Dementia with Lewy Bodies (DLB). Background: Recent studies have reported higher sensitivity and specificity for occipital and cingulate hypometabolism on FDG-PET of DLB patients. Methods: This retrospective chart review looked at regions of interest (ROI's) in FDG-PET CT scan reports in 35 consecutive patients with a clinical diagnosis of probable, possible, or definite DLB as defined by the latest DLB Consortium Report...
2018: Journal of Alzheimer's Disease and Parkinsonism
https://www.readbyqxmd.com/read/29656189/quantitative-electroencephalography-as-a-marker-of-cognitive-fluctuations-in-dementia-with-lewy-bodies-and-an-aid-to-differential-diagnosis
#13
Myrto Stylianou, Nicholas Murphy, Luis R Peraza, Sara Graziadio, Ruth Cromarty, Alison Killen, John T O' Brien, Alan J Thomas, Fiona E N LeBeau, John-Paul Taylor
OBJECTIVE: We investigated for quantitative EEG (QEEG) differences between Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) patients and healthy controls, and for QEEG signatures of cognitive fluctuations (CFs) in DLB. METHODS: We analysed eyes-closed, resting state EEGs from 18 AD, 17 DLB and 17 PDD patients with mild dementia, and 21 age-matched controls. Measures included spectral power, dominant frequency (DF), frequency prevalence (FP), and temporal DF variability (DFV), within defined EEG frequency bands and cortical regions...
April 3, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29653315/eeg-based-neurophysiological-indicators-of-hallucinations-in-alzheimer-s-disease-comparison-with-dementia-with-lewy-bodies
#14
Meenakshi Dauwan, Mascha M J Linszen, Afina W Lemstra, Philip Scheltens, Cornelis J Stam, Iris E Sommer
We studied neurophysiological indicators of hallucinations in Alzheimer's disease patients with hallucinations (ADhall+), and compared them with nonhallucinating AD (ADhall-) and dementia with Lewy bodies (DLBhall+) patients. Thirty-six matched ADhall+ and 108 ADhall- and 29 DLBhall+ patients were selected from the Amsterdam Dementia Cohort. Electroencephalography (EEG) spectral and functional connectivity (FC) analyses (phase lag index) were performed. Quantitative and visual EEG measures were combined in a random forest algorithm to determine which EEG-based variable(s) play a role in hallucinations...
March 19, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29629495/lewy-body-disease-clinical-and-pathological-overlap-syndrome-between-synucleinopathies-parkinson-disease-and-tauopathies-alzheimer-disease
#15
REVIEW
Clovis Foguem, Patrick Manckoundia
Lewy body disease (LBD) is a neurodegenerative disease resulting in dementia. It shares clinical and pathological features with Parkinson disease (PD), the most frequent synucleinopathy, Parkinson disease dementia (PDD), and Alzheimer disease (AD), a tauopathy. Even though the diagnostic criteria for these neurodegenerative diseases are clearly established, and recently revised for LBD, their precise clinical diagnosis is often difficult because LBD, PD, PDD, and AD share epidemiological, clinical, and pathological characteristics...
April 8, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29624752/biomarkers-for-cognitive-impairment-in-lewy-body-disorders-status-and-relevance-for-clinical-trials
#16
REVIEW
Andrew Siderowf, Dag Aarsland, Brit Mollenhauer, Jennifer G Goldman, Bernard Ravina
Biomarkers have the potential to improve diagnosis and prognosis, and guide clinical treatment decisions. In research, biomarkers can be used for patient selection and as outcome measures in clinical trials. A range of biochemical and imaging biomarkers are relevant to patients with Lewy body disorders, including PD, PD dementia, and dementia with Lewy bodies. Dopaminergic imaging is used for differential diagnosis of parkinsonian disorders versus tremor disorders without dopamingeric deficits, and also to differentiate dementia with Lewy bodies from Alzheimer's disease...
April 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29623065/-in-situ-proximity-ligation-assay-reveals-co-localization-of-alpha-synuclein-and-snare-proteins-in-murine-primary-neurons
#17
Leire Almandoz-Gil, Emma Persson, Veronica Lindström, Martin Ingelsson, Anna Erlandsson, Joakim Bergström
The aggregation of alpha-synuclein (αSyn) is the pathological hallmark of Parkinson's disease, dementia with Lewy bodies and related neurological disorders. However, the physiological function of the protein and how this function relates to its pathological effects remain poorly understood. One of the proposed roles of αSyn is to promote the soluble N -ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly by binding to VAMP-2. The objective of this study was to visualize the co-localization between αSyn and the SNARE proteins (VAMP-2, SNAP-25, and syntaxin-1) for the first time using in situ proximity ligation assay (PLA)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29621183/tau-induced-pathology-in-epilepsy-and-dementia-notions-from-patients-and-animal-models
#18
REVIEW
Marina P Sánchez, Ana M García-Cabrero, Gentzane Sánchez-Elexpuru, Daniel F Burgos, José M Serratosa
Patients with dementia present epilepsy more frequently than the general population. Seizures are more common in patients with Alzheimer's disease (AD), dementia with Lewy bodies (LBD), frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP) than in other dementias. Missense mutations in the microtubule associated protein tau (MAPT) gene have been found to cause familial FTD and PSP, while the P301S mutation in MAPT has been associated with early-onset fast progressive dementia and the presence of seizures...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29619853/multi-modality-molecular-imaging-characteristics-of-dementia-with-lewy-bodies
#19
Zhong-Bao Gao, Wei Wang, Xing-Li Zhao, Tong Chen, Li-Ping Fu, Bai-Xuan Xu, Zhen-Fu Wang
Objective Dementia with Lewy bodies (DLB) is a common type of neurodegenerative dementia. Molecular neuroimaging using dopamine transporter (DaT), Pittsburgh compound B (PIB), and fluorodeoxyglucose (FDG) positron emission tomography (PET) has advantages in detecting dopaminergic neuron loss, abnormal amyloid β-protein deposition, and glucose metabolism changes in patients with neurodegenerative disorders. However, the multi-modality molecular imaging features of patients with DLB have rarely been reported...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29617933/a-qualitative-study-of-female-caregiving-spouses-experiences-of-intimate-relationships-as-cognition-declines-in-parkinson-s-disease
#20
Sabina Vatter, Kathryn R McDonald, Emma Stanmore, Linda Clare, Sheree A McCormick, Iracema Leroi
Background: the complex and progressive nature of Parkinson's disease (PD) and cognitive impairment may necessitate a care provider, a role which is frequently undertaken by a spouse. Providing and receiving care related to dementia impacts on a couple's partnership and may result in decreased intimacy and relationship satisfaction. Objective: to explore the changes in long-term intimate relationships in Parkinson's-related dementia, as perceived by spouses providing care to their partners...
April 3, 2018: Age and Ageing
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