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https://www.readbyqxmd.com/read/29351170/risk-of-preterm-birth-following-late-pregnancy-exposure-to-nsaids-or-cox-2-inhibitors
#1
Anick Bérard, Odile Sheehy, Sylvie Girard, Jin-Ping Zhao, Sasha Bernatsky
Pregnant women may take non-steroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitors or biologic agents to relieve symptoms or manage disease flares in late pregnancy. We aimed to quantify the risk of prematurity associated with late pregnancy exposure to non-selective NSAIDs, selective COX-2 inhibitors and biologic agents. Using data from Quebec Pregnancy Cohort, we performed a population-based cohort study. We included all women who were covered by the Quebec Drug Plan and had a singleton livebirth between 1/1/1998 and 31/12/2009...
January 18, 2018: Pain
https://www.readbyqxmd.com/read/29351114/sexual-and-reproductive-issues-and-inflammatory-bowel-disease-a-neglected-topic-in-men
#2
Mariangela Allocca, Daniela Gilardi, Gionata Fiorino, Federica Furfaro, Laurent Peyrin-Biroulet, Silvio Danese
There has been considerable literature on sexual issues in women with inflammatory bowel disease (IBD), but relatively little attention has been paid to these aspects in men. To review the available literature and to provide the best management of sexual and reproductive issues in male patients with IBD. The scientific literature on sexual and reproductive issues in men with IBD was reviewed. Several factors, including surgical and medication treatments, disease activity, lifestyle, and psychological factors, may play a role in the development of infertility and sexual dysfunction and may negatively impact pregnancy outcomes...
January 18, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29341431/risk-of-infantile-hemangiomas-in-the-offspring-of-women-with-autoimmune-disease-and-the-pathogenic-implications-of-these-lesions
#3
Chelsey J F Smith, Kenneth L Jones, Diana L Johnson, Gretchen Bandoli, Loan K Robinson, Arthur Kavanaugh, Christina D Chambers
The purpose of this study was to analyze the risk of maternal autoimmune disease or associated treatments on infantile hemangiomas (IHs), a common benign vascular tumor in infants, and to better understand how maternal chronic inflammation may play a factor in the pathogenesis of these lesions. Eligible women from the United States and Canada who enrolled before 19 weeks' gestation and delivered at least one live born infant were recruited as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project from 2004-2013...
January 17, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29339690/the-rationale-and-design-of-the-national-peripartum-cardiomyopathy-registries-in-turkey-the-artemis-i-and-artemis-ii-studies
#4
Meral Kayıkçıoğlu, Lale Tokgözoğlu, Ferit Onur Mutluer, Dilek Ural, Murat Biteker
OBJECTIVE: Peripartum cardiomyopathy (PPCM) is left ventricular (LV) systolic dysfunction with an ejection fraction of ≤45% occurring in the later stages of pregnancy or soon after delivery. Although various risk factors have been identified, the exact cause of the disease is unknown. Unlike most countries in the European region, Turkey has yet to determine the current PPCM burden. A registry for this purpose does not exist. To close this gap, the A RegisTry of pEripartuM cardIomyopathy in Turkish patientS (ARTEMIS-I and ARTEMIS-II), was planned and endorsed by the Turkish Society of Cardiology...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29337985/increased-risk-of-ischemic-heart-disease-hypertension-and-type-2-diabetes-in-women-with-previous-gestational-diabetes-mellitus-a-target-group-in-general-practice-for-preventive-interventions-a-population-based-cohort-study
#5
Barbara Daly, Konstantinos A Toulis, Neil Thomas, Krishna Gokhale, James Martin, Jonathan Webber, Deepi Keerthy, Kate Jolly, Ponnusamy Saravanan, Krishnarajah Nirantharakumar
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with developing type 2 diabetes, but very few studies have examined its effect on developing cardiovascular disease. METHODS AND FINDINGS: We conducted a retrospective cohort study utilizing a large primary care database in the United Kingdom. From 1 February 1990 to 15 May 2016, 9,118 women diagnosed with GDM were identified and randomly matched with 37,281 control women by age and timing of pregnancy (up to 3 months)...
January 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29335319/preterm-delivery-and-future-risk-of-maternal-cardiovascular-disease-a-systematic-review-and-meta-analysis
#6
REVIEW
Pensée Wu, Martha Gulati, Chun Shing Kwok, Chun Wai Wong, Aditya Narain, Shaughn O'Brien, Carolyn A Chew-Graham, Ganga Verma, Umesh T Kadam, Mamas A Mamas
BACKGROUND: Preterm delivery (<37 weeks gestational age) affects 11% of all pregnancies, but data are conflicting whether preterm birth is associated with long-term adverse maternal cardiovascular outcomes. We aimed to systematically evaluate and summarize the evidence on the relationship between preterm birth and future maternal risk of cardiovascular diseases. METHODS AND RESULTS: A systematic search of MEDLINE and EMBASE was performed to identify relevant studies that evaluated the association between preterm birth and future maternal risk of composite cardiovascular disease, coronary heart disease, stroke, and death caused by cardiovascular or coronary heart disease and stroke...
January 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29331749/paediatric-dysgerminoma-results-of-three-consecutive-french-germ-cell-tumours-clinical-studies-tgm-85-90-95-with-late-effects-study
#7
Gwénaëlle Duhil de Bénazé, Hélène Pacquement, Cécile Faure-Conter, Catherine Patte, Daniel Orbach, Nadège Corradini, Claire Berger, Hélène Sudour-Bonnange, Cécile Vérité, Hélène Martelli, Brice Fresneau
METHODS: French patients (≤18years) treated for dysgerminoma between 1985 and 2005 in TGM-85, 90, 95 protocols were included. Treatment was based on primary unilateral oophorectomy followed by prophylactic lymph node irradiation (1985-1998) or a wait-and-see strategy (1998-2005) for localised completely resected tumours (pS1) or by platinum-based chemotherapy for advanced diseases. RESULTS: Forty-eight patients (median age 12.8 years) were included. Six patients had gonadal dysgenesis...
January 10, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29319589/preconception-care-for-the-general-ob-gyn
#8
Jessica C Arluck, Allison C Mayhew
Preconception counseling is an important aspect of the care of reproductive-aged women. Asking each woman with each interaction her wishes regarding pregnancy allows the health care provider to investigate her history. The areas to review include environmental toxins, nutrition, genetics, substance abuse, medical conditions, infectious diseases, and psychosocial issues. Then preconception counseling can be individualized. The goal is to decrease or eliminate risks that can cause detriments to the patient or her future pregnancies...
March 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29319359/secondary-and-tertiary-preventions-of-thyroid-disease
#9
Fereidoun Azizi, Ladan Mehran, Farhad Hosseinpanah, Hossein Delshad, Atieh Amouzegar
INTRODUCTION: Secondary and tertiary preventions are concerned with the recognition of the disease process in a very early stage and delay in progression to complete disease and minimization of complications and the impact of illness. METHODS: All articles related to secondary and tertiary prevention of thyroid diseases were reviewed. Using related key words, articles published between 2001 and 2015 were evaluated, categorized, and analyzed. RESULTS: In secondary prevention, congenital hypothyroidism and subclinical hypo and hyperthyroidism are equally important...
January 10, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29318926/assessment-of-preeclampsia-risk-by-use-of-serum-ionized-magnesium-based-equation
#10
Chatchai Kreepala, Maethaphan Kitporntheranunt, Worrawat Sangwipasnapaporn, Warit Rungsrithananon, Krittanont Wattanavaekin
BACKGROUND: Preeclampsia is a common medical complication in pregnancy. It has been reported to be associated with decreased serum magnesium levels. However, there has not been evidence demonstrating utilization of change in magnesium for prediction of preeclampsia. The purpose of this study was to develop magnesium fraction-based equations which took other significant clinical risk factors into consideration for prediction of preeclampsia. METHODS: We collected serum total and ionized magnesium ionized magnesium levels from 84 pregnant women diagnosed with preeclampsia after week 20 of pregnancy...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29317608/epigenetics-and-cerebral-organoids-promising-directions-in-autism-spectrum-disorders
#11
REVIEW
Sheena Louise Forsberg, Mirolyuba Ilieva, Tanja Maria Michel
Autism spectrum disorders (ASD) affect 1 in 68 children in the US according to the Centers for Disease Control and Prevention (CDC). It is characterized by impairments in social interactions and communication, restrictive and repetitive patterns of behaviors, and interests. Owing to disease complexity, only a limited number of treatment options are available mainly for children that alleviate but do not cure the debilitating symptoms. Studies confirm a genetic link, but environmental factors, such as medications, toxins, and maternal infection during pregnancy, as well as birth complications also play a role...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29313509/patients-families-perceptions-of-lupus-in-sub-saharan-africa
#12
J Iba Ba, M Ouédraogo, Y S Oliveira, I Nseng Nseng, A Abo Ekomie, J B Boguikouma
Lupus is an autoimmune disease affecting the connective tissue. Its clinical and biological polymorphism is often misunderstood by patients and families and can lead to treatment interruption and a decision to turn to alternative medicine. We used a questionnaire to assess the degree of knowledge of this disease of family members living with lupus patients. Of the 56 lupus patients receiving regular follow-up at our hospital, 123 members of 30 of their families (53.5%) participated. Overall, among these families, 81...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29305253/chronic-hypertension-first-trimester-blood-pressure-control-and-likelihood-of-severe-hypertension-preeclampsia-and-small-for-gestational-age
#13
Diane Nzelu, Dan Dumitrascu-Biris, Kypros H Nicolaides, Nikos A Kametas
BACKGROUND: There is extensive evidence that pre-pregnancy chronic hypertension is associated with high risk of development of severe hypertension and preeclampsia and birth of small for gestational age neonates. However, previous studies have not reported whether anti-hypertensive use, blood pressure control or normalization of blood pressure during early pregnancy influence the rates of these pregnancy complications. OBJECTIVE: To stratify women with pre-pregnancy chronic hypertension according to the use of antihypertensive medications and level of blood pressure control at the first hospital visit during the first-trimester of pregnancy and examine the rates of severe hypertension, preeclampsia and birth of small for gestational age neonates according to such stratification...
January 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29304364/systematic-review-of-health-related-quality-of-life-and-patient-reported-outcome-measures-in-gestational-trophoblastic-disease-a-parallel-synthesis-approach
#14
REVIEW
Jane Ireson, Georgina Jones, Matthew C Winter, Stephen C Radley, Barry W Hancock, John A Tidy
Gestational trophoblastic disease is a rare complication of pregnancy that can develop into cancer. Medical outcomes of gestational trophoblastic disease are well researched, but the effect of the disease on health-related quality of life (HRQOL) requires attention if care is to be improved. This systematic review was designed to establish the effect of gestational trophoblastic disease and its treatment on HRQOL and to identify the appropriateness of HRQOL measures. Quantitative studies found HRQOL in long-term survivors of gestational trophoblastic disease to be at or above population norms...
January 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29302186/risks-versus-benefits-of-medication-use-during-pregnancy-what-do-women-perceive
#15
Bianca Mulder, Maarten J Bijlsma, Catharina Cm Schuiling-Veninga, Leonard P Morssink, Eugene van Puijenbroek, Jan G Aarnoudse, Eelko Hak, Tjalling W de Vries
Background: Understanding perception of risks and benefits is essential for informed patient choices regarding medical care. The primary aim of this study was to evaluate the perception of risks and benefits of 9 drug classes during pregnancy and associations with women's characteristics. Methods: Questionnaires were distributed to pregnant women who attended a Dutch Obstetric Care facility (first- and second-line care). Mean perceived risk and benefit scores were computed for 9 different drug classes (paracetamol, antacids, antibiotics, antifungal medication, drugs against nausea and vomiting, histamine-2 receptor antagonists/proton pump inhibitors, antidepressants, nonsteroidal anti-inflammatory drugs, and sedatives/anxiolytics)...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29288157/history-of-adverse-pregnancy-outcomes-blood-pressure-and-subclinical-vascular-measures-in-late-midlife-swan-study-of-women-s-health-across-the-nation
#16
Yamnia I Cortés, Janet M Catov, Maria Brooks, Siobán D Harlow, Carmen R Isasi, Elizabeth A Jackson, Karen A Matthews, Rebecca C Thurston, Emma Barinas-Mitchell
BACKGROUND: Adverse pregnancy outcomes, such as preterm birth (PTB), have been associated with elevated risk of maternal cardiovascular disease, but their effect on late midlife blood pressure (BP) and subclinical vascular measures remains understudied. METHODS AND RESULTS: We conducted a cross-sectional analysis with 1220 multiethnic parous women enrolled in SWAN (Study of Women's Health Across the Nation) to evaluate the impact of self-reported history of adverse pregnancy outcomes (PTB, small-for-gestational-age, stillbirth), on maternal BP, mean arterial pressure, and subclinical vascular measures (carotid intima-media thickness, plaque, and pulse wave velocity) in late midlife...
December 29, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29287946/what-we-do-and-do-not-know-about-women-and-kidney-diseases-questions-unanswered-and-answers-unquestioned-reflection-on-world-kidney-day-and-international-woman-s-day
#17
Giorgina B Piccoli, Mona Alrukhaimi, Zhi-Hong Liu, Elena Zakharova, Adeera Levin
Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly...
December 26, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29284936/maternal-risk-factors-and-periodontal-disease-a-cross-sectional-study-among-postpartum-mothers-in-tamil-nadu
#18
Rohini Govindasamy, Manikandan Dhanasekaran, Sheeja S Varghese, V R Balaji, B Karthikeyan, Ananthi Christopher
Background and Aim: It is inconclusive that periodontitis is an independent risk factor for adverse pregnancy outcomes. This study aims to investigate the association between maternal periodontitis and preterm and/or low birth weight babies. Settings and Design: This was a prospective cross-sectional study. After prior informed consent, 3500 postpartum mothers were selected from various hospitals in Tamil Nadu and categorized into the following groups: group-1 - Normal term normal birth weight (n = 1100); Group-2 - Preterm normal birth weight (n = 400); Group-3 - preterm low birth weight (PTLBW) (n = 1000); and Group-4 - Normal term low birth weight (n = 1000)...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284159/characteristics-and-clinical-outcomes-of-living-renal-donors-in-hong-kong
#19
Y L Hong, C H Yee, C B Leung, J Yc Teoh, B Ch Kwan, P Kt Li, S Sm Hou, C F Ng
INTRODUCTION: In Asia, few reports are available on the outcomes for living renal donors. We report the short- and long-term clinical outcomes of individuals following living donor nephrectomy in Hong Kong. METHODS: We retrospectively reviewed the characteristics and clinical outcomes of all living renal donors who underwent surgery from January 1990 to December 2015 at our centre in Hong Kong. Information was obtained from hospital records and territory-wide electronic patient records...
December 29, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29273008/implementation-of-guidelines-for-multidisciplinary-team-management-of-pregnancy-in-women-with-pre-existing-diabetes-or-cardiac-conditions-results-from-a-uk-national-survey
#20
Cath Taylor, David R McCance, Lucy Chappell, Catherine Nelson-Piercy, Sara A Thorne, Khaled M K Ismail, James S A Green, Debra Bick
BACKGROUND: Despite numerous publications stating the importance of multidisciplinary care for women with pre-existing medical conditions, there is a lack of evidence regarding structure or processes of multidisciplinary working, nor impact on maternal or infant outcomes. This study aimed to evaluate the implementation of guidelines for multidisciplinary team (MDT) management in pregnant women with pre-existing diabetes or cardiac conditions. These conditions were selected as exemplars of increasingly common medical conditions in pregnancy for which MDT management is recommended to prevent or reduce adverse maternal and fetal outcomes...
December 22, 2017: BMC Pregnancy and Childbirth
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