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Keratoconus

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https://www.readbyqxmd.com/read/28811794/comparing-the-effects-of-two-different-contact-lenses-on-corneal-re-epithelialization-after-corneal-collagen-cross-linking
#1
Yusuf Kocluk, Savas Cetinkaya, Emine Alyamac Sukgen, Murat Günay, Alper Mete
OBJECTIVE: To investigate whether keratoconus (KC) patients who applied the corneal collagen cross-linking (CXL) and two different contact lens (CL) showed any differences in complaints and findings following the CXL. METHODS: This prospective, comparative, double-blind clinical study involved 60 eyes of 60 patients (38 female and 22 male). At the end of the CXL procedure, CL (Balafilcon A) was inserted in 29 patients (Group-1) while CL with different material content (Hioxifilcon A) designed for therapeutic/bandage purposes were inserted in 31 patients (Group-2)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811773/transepithelial-corneal-crosslinking-in-treatment-of-progressive-keratoconus-12-months-clinical-results
#2
Bushra Akbar, Rana Intisar-Ul-Haq, Mazhar Ishaq, Sabahat Arzoo, Kashif Siddique
OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of transepithelial corneal collagen cross linking (TE-CXL) with modified riboflavin and accelerated UVA irradiance in thin corneas with pachymetry less than 400 microns at thinnest point, untreatable by epithelium off corneal collagen cross linking (CXL) in adult Pakistani population with progressive keratoconus. METHODS: This quasi experimental study included twenty six eyes of 26 patients with progressive keratoconus who underwent accelerated transepithelial CXL in Armed forced institute of ophthalmology with 12 months follow up...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28810283/-comparison-of-discriminant-analysis-and-decision-trees-for-the-detection-of-subclinical-keratoconus
#3
Sonja Kleinhans, Eva Herrmann, Thomas Kohnen, Jens Bühren
Background Iatrogenic keratectasia is one of the most dreaded complications of refractive surgery. In most cases, keratectasia develops after refractive surgery of eyes suffering from subclinical stages of keratoconus with few or no signs. Unfortunately, there has been no reliable procedure for the early detection of keratoconus. In this study, we used binary decision trees (recursive partitioning) to assess their suitability for discrimination between normal eyes and eyes with subclinical keratoconus. Patients and Methods The method of decision tree analysis was compared with discriminant analysis which has shown good results in previous studies...
August 15, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28808911/methicillin-resistant-staphylococcus-aureus-acute-keratitis-after-intracorneal-ring-segment-implantation
#4
Gonzalo García de Oteyza, Andrea Laiseca, Paola Sauvageot, Juan Álvarez de Toledo
INTRODUCTION: The purpose of this study was to report the first case of acute bacterial keratitis produced by methicillin-resistant Staphylococcus aureus after the implantation of two intracorneal ring segments during an uneventful procedure for treating keratoconus in a 13-year-old child. CASE REPORT: A patient with grade III keratoconus underwent an implantation of intracorneal ring segments with no complications during the procedure. Three days later, a whitish corneal infiltrate appeared in between the union of both corneal rings...
August 14, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28808586/quality-of-vision-after-deep-anterior-lamellar-keratoplasty-fluid-dissection-compared-to-penetrating-keratoplasty-for-the-treatment-of-keratoconus
#5
Islam Mahmoud Hamdi, Momen Mahmoud Hamdi
PURPOSE: To compare the visual quality of patients with keratoconus who underwent penetrating keratoplasty (PKP) or deep anterior lamellar keratoplasty (DALK) with fluid dissection. DESIGN: Cross-sectional, observational study. METHODS: Twelve eyes that underwent PKP (PKP group) were compared to 24 eyes that underwent DALK (DALK group) after complete removal of sutures and stability of refraction. Visual, refractive, corneal topographic, corneal aberrometry, and ocular aberrometry parameters were compared for both groups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28802685/results-at-7years-after-cross-linking-procedure-in-keratoconic-patients
#6
C Nicula, N Dorin, P R Nicolae
PURPOSE: Long-term evaluation of functional results based on visual acuity, keratometry, spherical equivalent and refractive cylinder in patients with progressive keratoconus treated with corneal collagen cross-linking (CXL). MATERIALS AND METHODS: We studied a group of 114 eyes of 91 consecutive patients treated from 2006 to 2009 by "Epi-off type" CXL. In the preoperative period, all patients had a complete ophthalmologic examination. The inclusion criteria were: patients aged 15 to 54years, with various stages of keratoconus, with a corneal thickness of at least 400μm at the thinnest point...
August 9, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28794613/association-of-fluorescein-anterior-corneal-mosaic-and-corneal-k-structures-by-in-vivo-laser-confocal-microscopy-in-patients-with-keratoconus
#7
Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori, Toshinori Masaki, Kazuhisa Sugiyama
OBJECTIVE: To report the in vivo laser confocal microscopy findings of corneas with keratoconus, with special attention to abnormality of Bowman's layer and sub-Bowman's fibrous structures (Kobayashi-structures [K-structures]). METHODS: Sixteen keratoconic eyes in 8 consecutive patients with keratoconus (4 males, 4 females, mean age, 41.1 years) were included in this study. Slit-lamp biomicroscopic photos were taken with or without fluorescein staining. The existence of anterior corneal mosaic (ACM) after eyelid rubbing under fluorescein staining was documented...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28791057/evaluation-of-changes-in-visual-acuity-contrast-sensitivity-and-aberrations-in-patients-with-keratoconus-after-corneal-collagen-cross-linking
#8
Siamak Zarei-Ghanavati, Hamid Khakshour, Mohammadreza Vejdani, Haleh Ghooshkhanei, Amirhosein Vejdani
PURPOSE: To assess and compare preoperative refractive, aberrometric, topographic, and contrast sensitivity (CS) measurements with postoperative values after corneal collagen cross-linking (CXL) in patients with progressive keratoconus. METHODS: Twenty-two eyes of 11 patients with keratoconus were enrolled in this prospective study. Uncorrected distance visual acuity (UDVA), best spectacle corrected visual acuity (BSCVA), CS, and higher order aberrations (HOAs) were evaluated at baseline and 1, 3, 6, and 8 months after surgery...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28782505/chronic-pesticide-exposure-and-consequential-keratectasia-corneal-neovascularisation
#9
Shalini Sanyal, Atrayo Law, Sujata Law
Ocular toxicity as a consequence of chronic pesticide exposure is one of the health hazards caused due to extended exposure to pesticides. The cornea, due to its position as the outer ocular layer and its role in protecting the internal layers of the eye; is gravely affected by this xenobiotic insult to the eye, leading to ocular irritation and damage to normal vision. The deleterious effects of chronic pesticide exposure on the various corneal layers and the ocular risks involved therein, were explored by mimicking the on-field scenario...
August 4, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28777776/immunologic-rejection-episodes-after-deep-anterior-lamellar-keratoplasty-incidence-and-risk-factors
#10
Andres Gonzalez, Marianne O Price, Matthew T Feng, Christopher Lee, Juan G Arbelaez, Francis W Price
PURPOSE: To assess the rejection episode rate after deep anterior lamellar keratoplasty (DALK) and to identify associated risk factors. METHODS: This retrospective review of 251 primary DALK procedures performed by 14 surgeons at a single center between February 2008 and November 2015 evaluated the rejection episode rate and associated risk factors using Kaplan-Meier survival and proportional hazards analyses, which took the length of follow-up into consideration...
September 2017: Cornea
https://www.readbyqxmd.com/read/28775329/transient-ingrowth-of-lymphatic-vessels-into-the-physiologically-avascular-cornea-regulates-corneal-edema-and-transparency
#11
Deniz Hos, Anne Bukowiecki, Jens Horstmann, Felix Bock, Franziska Bucher, Ludwig M Heindl, Sebastian Siebelmann, Philipp Steven, Reza Dana, Sabine A Eming, Claus Cursiefen
Lymphangiogenesis is essential for fluid homeostasis in vascularized tissues. In the normally avascular cornea, however, pathological lymphangiogenesis mediates diseases like corneal transplant rejection, dry eye disease, and allergy. So far, a physiological role for lymphangiogenesis in a primarily avascular site such as the cornea has not been described. Using a mouse model of perforating corneal injury that causes acute and severe fluid accumulation in the cornea, we show that lymphatics transiently and selectively invade the cornea and regulate the resolution of corneal edema...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28763562/chondroitin-sulfate-based-biocompatible-crosslinker-restores-corneal-mechanics-and-collagen-alignment
#12
Xiaokun Wang, Shoumyo Majumdar, Garret Ma, Jeeyeon Sohn, Samuel C Yiu, Walter Stark, Awad Al-Qarni, Deepak P Edward, Jennifer H Elisseeff
Purpose: To evaluate the crosslinking effect of functionalized chondroitin sulfate (CS) in an ex vivo rabbit cornea model. Methods: Chondroitin sulfate molecules were chemically modified with the N-hydroxysuccinimide (NHS) group. Enucleated rabbit eyes were crosslinked with 2, 5, or 10 mg/mL CS-NHS solution for 30 or 60 minutes. The CS-NHS penetration, corneal swelling ratio, Young's modulus, and ultrastructure of the crosslinked corneas were characterized. In addition, rabbit corneas were further treated with a collagenase-chondroitinase solution to create an ex vivo keratoconus (KC)-like model...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28759945/scotopic-contrast-sensitivity-and-glare-after-accelerated-corneal-cross-linking
#13
Soheila Asgari, Hassan Hashemi, Alireza Mohamadi, Ebrahim Jafarzadehpur, Mohammad Miraftab, Saied Shahhoseini, Shiva Mehravaran, Akbar Fotouhi
BACKGROUND: The aim was to assess one-year changes in uncorrected and corrected contrast sensitivity (CS) and glare under scotopic conditions after accelerated cross-linking (CXL) using the 18 mW/cm(2) protocol for the treatment of progressive keratoconus and compare results with unoperated controls. METHODS: In this non-randomised clinical trial, 30 eyes were enrolled in the CXL group and 30 were assigned to the control group. Scotopic CS at spatial frequencies (SFs) of 0...
July 31, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28755306/keratoconus-treatment-algorithm
#14
REVIEW
Konstantinos D Andreanos, Kate Hashemi, Myrsini Petrelli, Konstantinos Droutsas, Ilias Georgalas, George D Kymionis
Keratoconus management has significantly changed over the last two decades. The advent of new interventions such as cornea cross-linking, intrastromal corneal ring segments, and combined treatments provide corneal clinicians a variety of treatment options for the visual rehabilitation of keratoconus patients. This review summarizes current evidence for these treatments and highlights their place in keratoconus management while new promising emerging therapies are being investigated.
July 28, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28749897/role-of-scleral-contact-lenses-in-management-of-coexisting-keratoconus-and-stevens-johnson-syndrome
#15
Varsha M Rathi, Mukesh Taneja, Srikanth Dumpati, Preeji S Mandathara, Virender S Sangwan
PURPOSE: To report the rare coexistence of keratoconus and Stevens-Johnson syndrome (SJS) managed with scleral contact lenses (ScCLs). METHODS: This is a retrospective case series. Five patients (9 eyes) who had coexisting SJS and corneal ectasia were identified from the database during the 2-year period. Diagnosis of SJS was based on a positive history of drug reactions, signs of ocular surface disease, and the presence of keratinization of lid margins. Keratoconus was diagnosed by slit-lamp biomicroscopy...
July 26, 2017: Cornea
https://www.readbyqxmd.com/read/28749896/elimination-of-anterior-corneal-steepening-with-descemet-membrane-endothelial-keratoplasty-in-a-patient-with-fuchs-dystrophy-and-keratoconus-implications-for-iol-calculation
#16
Reena Gupta, Ruta Kinderyte, Deborah S Jacobs, Ula V Jurkunas
PURPOSE: To report a case of coexistent Fuchs endothelial corneal dystrophy (FECD) and keratoconus (KCN) in which there was normalization of corneal topography after Descemet membrane endothelial keratoplasty (DMEK). METHODS: Retrospective medical record review. RESULTS: Preoperative findings revealed a best-corrected visual acuity of 20/40 with -1.00 - 2.50 × 147, topographic maximum keratometry of 50.8 D with inferior steeping, and confluent guttae in the left eye...
July 26, 2017: Cornea
https://www.readbyqxmd.com/read/28749895/mechanical-modeling-of-a-keratoconic-cornea
#17
Jean Marc Perone, Jean Baptiste Conart, Pierre-Jean Bertaux, Nicolas Sujet-Perone, Nadia Ouamara, Maxime Sot, Jean Jacques Henry
PURPOSE: We created a laboratory model of a cornea that was subjected to various pressures and thermal and mechanical factors to better understand the genesis of keratoconus deformation. METHODS: A steel base allowed for fixation of circular multilaminated patches of araldite (10 cm in diameter, 5 mm thick) in which the corneal anatomy was modeled. The model was plunged into a steam room (374°F/3 bars of pressure for 1 h) to ensure thermal homogeneity and was subjected to pressure using compressed air...
July 26, 2017: Cornea
https://www.readbyqxmd.com/read/28747634/changes-of-corneal-tomography-in-patients-with-congenital-blepharoptosis
#18
Tiepei Zhu, Xin Ye, Peifang Xu, Jingyi Wang, Huina Zhang, Hailong Ni, Zhaoan Su, Juan Ye
The study aimed to evaluate the effect of drooped eyelid on corneal tomography in congenital blepharoptosis patients. Sixty-four patients with congenital blepharoptosis and 64 age- and sex- matched healthy subjects were included. According to the eyelid margin to corneal light reflex distance (MRD), eyes with congenital blepharoptosis were categorized as mild, moderate, or severe. The eyes were scanned using the rotating Scheimpflug camera. Increased topometric parameters were observed in moderate and severe blepharoptosis...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28745650/-comparative-analysis-of-corneal-aberrations-after-intrastromal-segments-and-myoring-implantation-using-femtosecond-laser-in-patients-with-keratoconus
#19
N P Pashtaev, N A Pozdeeva, M V Sinitsyn
AIM: to comparatively analyze corneal aberrations after intrastromal corneal segments (ICS) and MyoRing implantation using femtosecond laser in patients with stage II-III keratoconus (KC) by Pentacam examination. MATERIAL AND METHODS: We have operated on 135 patients (145 eyes) with stage II or III KC. Depending on surgical technique, all patients were divided into two groups. Group I consisted of patients with KC, who received optimized femtosecond laser-assisted MyoRing implantation, group II - of those, who received femtosecond laser-assisted ICS implantation...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28742621/long-term-tomographic-evaluation-of-unilateral-keratoconus
#20
Lauren M Imbornoni, Prema Padmanabhan, Michael W Belin, M Deepa
PURPOSE: To report 5 cases of advanced unilateral keratoconus documented by sequential tomographic evaluation. METHODS: Retrospective review over a 10-year period at a single practice identifying patients with unilateral keratoconus by advanced imaging throughout the follow-up period. RESULTS: Five patients were identified with progressive keratoconus in 1 eye and no changes in the fellow eye based on full tomographic evaluation and analysis of both anterior and posterior corneal surfaces and corneal thickness with a mean follow-up period of 59 months (range 39-86)...
July 24, 2017: Cornea
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