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Keratoconus

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https://www.readbyqxmd.com/read/28211546/differential-effects-of-hormones-on-cellular-metabolism-in-keratoconus-in-vitro
#1
Tina B McKay, Jesper Hjortdal, Henrik Sejersen, Dimitrios Karamichos
Keratoconus (KC) is a corneal thinning disease with an onset commonly immediately post-puberty and stabilization by 40 to 50 years of age. The role of hormones in regulating corneal tissue structure in homeostatic and pathological conditions is unknown. Our group recently linked altered hormone levels to KC. Our current study sought to investigate and delineate the effects of exogenous hormones, such as androgen, luteotropin, and estrogen, on corneal stroma bioenergetics. We utilized our established 3D in vitro model to characterize the effects of DHEA, prolactin, 17β-estradiol on insulin-growth factor-1 and -2 (IGF-1, -2) signaling and metabolic function in primary corneal fibroblasts from healthy controls (HCFs) and KC patients (HKCs)...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28207827/replication-of-snp-associations-with-keratoconus-in-a-czech-cohort
#2
Petra Liskova, Lubica Dudakova, Anna Krepelova, Jiri Klema, Pirro G Hysi
INTRODUCTION: Keratoconus is a relatively frequent disease leading to severe visual impairment. Existing therapies are imperfect and clinical management may benefit from improved understanding of mechanisms leading to this disease. We aim to investigate the replication of 11 single nucleotide polymorphisms (SNPs) with keratoconus. METHODS: SNPs from loci previously found in association with keratoconus were genotyped in 165 keratoconus cases of Caucasian Czech origin (108 males and 57 females) and 193 population and gender-matched controls...
2017: PloS One
https://www.readbyqxmd.com/read/28197741/correlation-between-the-col4a3-mmp-9-and-timp-1-polymorphisms-and-risk-of-keratoconus
#3
Ramin Saravani, Davood Yari, Samira Saravani, Farzaneh Hasanian-Langroudi
PURPOSE: Keratoconus (KC) is thinning of the central cornea. Its etiology is unknown, but it may result from degrading of collagen type IV. The major protein in the cornea is collagen. Matrix metalloproteinase-9 (MMP-9) is able to degrade collagen type IV from the basement membrane and extracellular matrix (ECM). MMP-9 enzymatic activity is inhibited by the tissue inhibitor of metalloproteinase-1 (TIMP-1). In the present study, we sought to investigate and evaluate the effects of single nucleotide polymorphisms in COL4A3, MMP-9, and TIMP-1 on the risk of KC in an Iranian population sample...
February 14, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28197339/refractive-topographic-and-aberrometric-results-at-2-year-follow-up-for-accelerated-corneal-cross-link-for-progressive-keratoconus
#4
Ercüment Bozkurt, Engin Bilge Ozgurhan, Betul Ilkay Sezgin Akcay, Tugba Kurt, Yusuf Yildirim, Zehra Karaagaç Günaydin, Ahmet Demirok
Purpose. To report the visual, refractive, and corneal topography and wavefront aberration results of accelerated corneal cross-linking (CXL) during a 24-month follow-up. Methods. Forty-seven eyes underwent riboflavin-ultraviolet A-induced accelerated CXL treatment (30 mW/cm(2) with a total dose of 7.2 joules/cm(2)). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical and cylindrical values, keratometry (K) measurements (Ksteep, Kflat, Kavg, and Kapex), central corneal thickness, and anterior corneal aberrometric analyses including total wavefront error (WFE), total high order aberration (HOA), astigmatism, trefoil, coma, quadrafoil, secondary astigmatism, and spherical aberration were evaluated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28196224/loss-of-tryptophan-fluorescence-correlates-with-mechanical-stiffness-following-photo-crosslinking-treatment-of-rabbit-cornea
#5
Maura Williams, William Lewis, Walfre Franco
Purpose: A clinical treatment option for keratoconus involves the use of UV-initiated photo-crosslinking with riboflavin to increase corneal stiffness. Our study investigates whether endogenous fluorescence changes following treatment for keratoconus can be correlated to alterations in the stiffness of the cornea, thereby guiding treatment of keratoconus. Methods: A total of 78 ex vivo rabbit eyes were treated with either riboflavin-dextran solution plus UV light, dextran solution plus UV light, or riboflavin-dextran solution only for half treatment (2...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28192842/-keratoplasty-in-children-and-adolescents
#6
S J Lang, C Richter, O Richter, D Böhringer, G Geerling, T Reinhard
Background The conditions for long-term graft survival in infants and children are unfavorable, due to the different immunological features, the impaired clinical examination and the reduced compliance and treatment adherence. However, penetrating keratoplasty is often the only option to prevent amblyopia and there may be no alternative. We examined the different indications, graft survival and complications in two specialised centres. Material and Methods We identified all patients who were under the age of 18 years at the time of their penetrating keratoplasty...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28192838/topography-guided-prk-and-crosslinking-in-eyes-with-keratoconus-and-post-lasik-ectasia
#7
T M Müller, A P Lange
Topography-guided photorefractive keratectomy (TG-PRK) combined with corneal collagen crosslinking (CXL) has been shown to potentially improve vision and stabilize progression in patients with keratoconus (KC). We attempted to reproduce the previously published results using a different laser platform (AMARIS 500E) in patients with KC and post-LASIK ectasia (PLE). All of the 9 included eyes showed improved topography (Kmax, Kmean, RMS HOA, vertical coma, cylinder; p < 0.05) and improved visual acuity (BCVA, UCVA; p < 0...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28192590/tomographic-findings-after-implantation-of-ferrara-intrastromal-corneal-ring-segments-in-keratoconus
#8
João Marcelo Lyra, Daniela Lyra, Guilherme Ribeiro, Leonardo Torquetti, Paulo Ferrara, Aydano Machado
PURPOSE: To analyze and compare changes to the anterior and posterior corneal surfaces after Ferrara intracorneal ring segment (ICRS) (AJL, Boecillo, Spain) implantation and to correlate those changes with visual outcomes. METHODS: This retrospective case series study comprised consecutive patients with keratoconus implanted with the Ferrara ICRS. Computed tomography scans of the two corneal surfaces were obtained preoperatively and postoperatively with a rotating Scheimpflug imaging system...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28188148/analysis-of-sphingolipids-in-human-corneal-fibroblasts-from-normal-and-keratoconus-patients
#9
Hui Qi, Shrestha Priyadarsini, Sarah E Nicholas, Akhee Sarker-Nag, Jeremy Allegood, Charles E Chalfant, Nawajes A Mandal, Dimitrios Karamichos
The pathophysiology of human keratoconus (KC), a bilateral progressive corneal disease, leading to protrusion of the cornea, stromal thinning, and scarring is not well understood. In this study we investigated a novel Sphingolipid (SPL) signaling pathway through which KC may be regulated. Using human corneal fibroblasts (HCF) and human keratoconus cells (HKC) we examined the SPL pathway modulation. Both cell types were stimulated by the three TGF-β isoforms: TGF-B1 (T1), B2 (T2), and B3 (T3). All samples were analyzed using lipidomics, and real time-PCR...
February 10, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28165607/prevalence-of-eyelid-laxity-and-its-association-with-ophthalmic-findings-and-disease-severity-in-patients-with-keratoconus
#10
Mohammad Naderan, Ali Jahanrad, Mahgol Farjadnia
PURPOSE: To investigate the prevalence of eyelid laxity and quantify eyelid measurements in normal and keratoconic eyes and the correlations of these findings with ophthalmic parameters and disease severity in patients with keratoconus (KC). METHODS: In a prospective case-control study, prevalence of eyelid laxity and eyelid measurements were evaluated in 53 patients with KC and the same number of matched healthy controls. The eyelid measurements were compared between the groups, as well as mean keratometry (K), central and thinnest corneal thickness (CCT and TCT), astigmatism, manifest refraction spherical equivalent (MRSE), best spectacle-corrected visual acuity (BCVA), and severity of KC according to the Keratoconus Severity Score...
February 3, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28164597/visual-system-homeobox-1-vsx1-gene-analysis-in-keratoconus-design-of-specific-primers-and-dna-amplification-protocols-for-accurate-molecular-characterization
#11
Jun B Ng, Rozaida Y Y Poh, Kenneth R Lee, Visvaraja Subrayan, Jenny P Deva, Amy Y L Lau, Jin A M A Tan
BACKGROUND: Keratoconus is an ocular degeneration characterized by the thinning of corneal stroma that may lead to varying degrees of myopia and visual impairment. Genetic factors have been reported in the pathology of keratoconus where Asians have a higher incidence, earlier onset, and undergo earlier corneal grafts compared to Caucasians. The visual system homeobox 1 (VSX1) gene forms part of a paired-like homeodomain transcription factor which is responsible for ocular development...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28160249/evaluation-of-iontophoretic-collagen-cross-linking-for-early-stage-of-progressive-keratoconus-compared-to-standard-cross-linking-a-non-inferiority-study
#12
Alina Cantemir, Anisia I Alexa, Nicoleta Anton, Roxana E Ciuntu, Ciprian Danielescu, Dorin Chiselita, Danut Costin
INTRODUCTION: The purpose of this study was to evaluate the efficacy and safety of iontophoretic collagen cross-linking (I-CXL) compared to epithelium-off standard collagen cross-linking (CXL) in treating the early stages of progressive keratoconus. METHODS: This retrospective cohort study at Oftaprof Clinic, Iasi, Romania included 40 eyes of 40 patients with progressive keratoconus stage I according to the Amsler classification who underwent I-CXL and the results were compared with a matched group of 40 eyes from 40 patients who received standard CXL...
February 3, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28159702/a-case-of-feingold-type-2-syndrome-associated-with-keratoconus-refines-keratoconus-type-7-locus-on-chromosome-13q
#13
Fabio Sirchia, Eleonora Di Gregorio, Gabriella Restagno, Enrico Grosso, Patrizia Pappi, Flavia Talarico, Elisa Savin, Simona Cavalieri, Elisa Giorgio, Cecilia Mancini, Barbara Pasini, Jodhbir S Mehta, Alfredo Brusco
We report on a 58-year old woman with microcephaly, mild dysmorphic features, bilateral keratoconus, digital abnormalities, short stature and mild cognitive delay. Except for keratoconus, the phenotype was suggestive for Feingold syndrome type 2 (FGLDS2, MIM 614326), a rare autosomal dominant disorder described in six patients worldwide, due to the haploinsufficiency of MIR17HG, a micro RNA encoding gene. Karyotype showed a de novo deletion on chromosome 13q, further defined by array-Comparative Genomic Hybridization (a-CGH) to a 17...
January 31, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28145428/collagen-synthesis-disruption-and-downregulation-of-core-elements-of-tgf-%C3%AE-hippo-and-wnt-pathways-in-keratoconus-corneas
#14
Michal Kabza, Justyna A Karolak, Malgorzata Rydzanicz, Michał W Szcześniak, Dorota M Nowak, Barbara Ginter-Matuszewska, Piotr Polakowski, Rafal Ploski, Jacek P Szaflik, Marzena Gajecka
To understand better the factors contributing to keratoconus (KTCN), we performed comprehensive transcriptome profiling of human KTCN corneas for the first time using an RNA-Seq approach. Twenty-five KTCN and 25 non-KTCN corneas were enrolled in this study. After RNA extraction, total RNA libraries were prepared and sequenced. The discovery RNA-Seq analysis (in eight KTCN and eight non-KTCN corneas) was conducted first, after which the replication RNA-Seq experiment was performed on a second set of samples (17 KTCN and 17 non-KTCN corneas)...
February 1, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28138772/effect-of-corneal-collagen-crosslinking-on-subsequent-deep-anterior-lamellar-keratoplasty-dalk-in-keratoconus
#15
Friederike Schaub, Philip Enders, Björn O Bachmann, Ludwig M Heindl, Claus Cursiefen
PURPOSE: The purpose was to investigate the impact of ultraviolet light corneal collagen crosslinking (UV-CXL) on the success rate and clinical outcome of subsequent deep anterior lamellar keratoplasty (DALK) in eyes with keratoconus (KC). METHODS: Medical records of 101 consecutive eyes with KC scheduled for big-bubble DALK surgery were screened retrospectively for details of previously performed UV-CXL, as well as intra- and postoperative complications of DALK surgery...
January 30, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28138751/-recurrent-keratoconus-in-a-graft-too-small-of-a-graft-as-one-of-many-possible-explanations
#16
V Duisdieker, K U Löffler, F G Holz, M C Herwig-Carl
No abstract text is available yet for this article.
January 30, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28138750/-recurrent-keratoconus-due-to-too-small-of-a-graft
#17
M Jähne
No abstract text is available yet for this article.
January 30, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28133954/new-parameters-in-assessment-of-human-donor-corneal-stroma
#18
Marie Borderie, Kate Grieve, Kristina Irsch, Djida Ghoubay, Cristina Georgeon, Celine De Sousa, Laurent Laroche, Vincent M Borderie
PURPOSE: To provide quantitative parameters for assessment of human donor corneal stroma by imaging stromal features of diseased and normal human corneas with full-field optical coherence microscopy (FFOCM), using confocal microscopy (CM) and histology as reference techniques. METHODS: Bowman's layer (BL) thickness and keratocyte density were assessed ex vivo in 23 human donor corneas and 27 human pathological corneas (keratoconus and other corneal disorders) with FFOCM, CM and histology...
January 30, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28129292/persistent-epithelial-defects-and-corneal-opacity-after-collagen-cross-linking-with-substitution-of-dextran-t-500-with-dextran-sulfate-in-compounded-topical-riboflavin
#19
Roland Höllhumer, Stephanie Watson, Peter Beckingsale
PURPOSE: Collagen cross-linking (CXL) is a commonly performed procedure to prevent the progression of keratoconus. Riboflavin is an essential part of the procedure, which facilitates both the cross-linking process and protection of intraocular structures. Dextran can be added to riboflavin to create an isotonic solution. This case report highlights the importance of compounding riboflavin with the correct dextran solution. METHODS: A retrospective case series. RESULTS: Six eyes of 4 male patients with keratoconus aged from 20 to 38 years underwent CXL with substitution of 20% dextran (T-500) with 20% dextran sulfate in a compounded riboflavin 0...
March 2017: Cornea
https://www.readbyqxmd.com/read/28129291/characteristics-of-corneal-astigmatism-of-anterior-and-posterior-surface-in-a-normal-control-group-and-patients-with-keratoconus
#20
Mehdi Shajari, Stefan Friderich, Miad Pour Sadeghian, Ingo Schmack, Thomas Kohnen
PURPOSE: To evaluate and compare power and axis orientation of anterior and posterior astigmatism in eyes with keratoconus with healthy eyes. METHODS: In this retrospective cohort study, we examined 861 eyes of 494 patients diagnosed with keratoconus at the Department of Ophthalmology, University Hospital Frankfurt, and 256 eyes of 256 healthy individuals. Using a Scheimpflug device (Pentacam HR), we measured the magnitude and axis orientation of anterior and posterior corneal astigmatism, corneal thickness, and conus location...
January 26, 2017: Cornea
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