keyword
MENU ▼
Read by QxMD icon Read
search

Keratoconus

keyword
https://www.readbyqxmd.com/read/29780950/extreme-descemet-s-membrane-rupture-with-hydrops-in-keratoconus-clinical-and-histological-manifestations
#1
I-Ping Loh, Jennifer C Fan Gaskin, Trevor Sherwin, Charles N J McGhee
Purpose: To study the clinical and histological manifestations of an extreme Descemet's membrane rupture as a result of keratoconus. Observations: Using Periodic acid-Schiff assay to study a keratoconic cornea with an extreme rupture showed that the ruptured Descemet's membrane had retracted and folded into scrolls and ridges. The dimensions of the rupture were estimated to be 3.7mm2 , and the central cornea was extremely thinned with a thickness of only 260μm...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29778454/influence-of-the-beam-profile-crosslinking-setting-on-changes-in-corneal-topography-and-tomography-in-progressive-keratoconus-preliminary-results
#2
Robert Herber, Kathleen S Kunert, Věra Veliká, Eberhard Spoerl, Lutz E Pillunat, Frederik Raiskup
PURPOSE: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems. SETTING: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany. DESIGN: Retrospective case series. METHODS: Eyes from patients with progressive keratoconus were included...
May 16, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29777678/uva-riboflavin-collagen-crosslinking-stiffening-effects-on-anterior-and-posterior-corneal-flaps
#3
Hamed Hatami-Marbini, Sandeep M Jayaram
The UVA/riboflavin collagen crosslinking (CXL) is one of the treatment procedure for stopping the progression of keratoconus. The inclusion criterion for this procedure is a minimum corneal thickness of 400 μm, which is not often met in patients with advanced keratoconus. Preoperatively swelling of thin corneas was shown to stabilize the keratectasia without any postoperative endothelial damage. Recently, we have shown that swelling porcine corneas prior to the CXL treatment had no significant effect on the resulting improvement in their tensile properties...
May 16, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29771883/-transepithelial-corneal-collagen-crosslinking-in-patients-with-progressive-keratoconus
#4
A I Kopaenko, N V Ivanova
PURPOSE: To assess the effectiveness of transepithelial collagen crosslinking (CXL) in patients with keratoconus. MATERIAL AND METHODS: The study involved 44 patients (44 eyes) with stage I-II progressive keratoconus. Patients were divided into two groups. The 1st group included 22 patients that had underwent transepithelial CXL. The 2nd group included 22 patients that had underwent traditional CXL. RESULTS AND DISCUSSION: All patients of the group 2 all patients had corneal syndrome, which lasted 2-4 days...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29771749/brillouin-microscopy-assessing-ocular-tissue-biomechanics
#5
Seok Hyun Yun, Dimitri Chernyak
PURPOSE OF REVIEW: Assessment of corneal biomechanics has been an unmet clinical need in ophthalmology for many years. Many researchers and clinicians have identified corneal biomechanics as source of variability in refractive procedures and one of the main factors in keratoconus. However, it has been difficult to accurately characterize corneal biomechanics in patients. The recent development of Brillouin light scattering microscopy heightens the promise of bringing biomechanics into the clinic...
May 15, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29770640/comparison-of-anterior-posterior-and-total-corneal-astigmatism-measured-using-a-single-scheimpflug-camera-in-healthy-and-keratoconus-eyes
#6
Young Choi, Youngsub Eom, Jong Suk Song, Hyo Myung Kim
PURPOSE: To compare the effect of posterior corneal astigmatism on the estimation of total corneal astigmatism using anterior corneal measurements (simulated keratometry [K]) between eyes with keratoconus and healthy eyes. METHODS: Thirty-three eyes of 33 patients with keratoconus of grade I or II and 33 eyes of 33 age- and sex-matched healthy control subjects were enrolled. Anterior, posterior, and total corneal cylinder powers and flat meridians measured by a single Scheimpflug camera were analyzed...
May 15, 2018: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29767348/-dynamic-scheimpflug-analyzer-corvis-st-for-measurement-of-corneal-biomechanical-parameters-a-praxis-related-overview
#7
REVIEW
R Herber, N Terai, K R Pillunat, F Raiskup, L E Pillunat, E Spörl
BACKGROUND: Topographic and tomographic parameters alone are often not sufficient for early detection of corneal changes. Pathological alterations in the microstructure of the cornea occur before changes in topography and tomography can be detected. Biomechanical parameters show a strong correlation with microscopic structural changes. OBJECTIVE: The aim of the study was to gain information about the microscopic structure and consistency of the cornea by measuring biomechanical parameters...
May 16, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29760442/cross-ancestry-genome-wide-association-analysis-of-corneal-thickness-strengthens-link-between-complex-and-mendelian-eye-diseases
#8
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne E M Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline C W Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29758268/pathogenesis-of-keratoconus-the-intriguing-therapeutic-potential-of-prolactin-inducible-protein
#9
REVIEW
Rabab Sharif, Sashia Bak-Nielsen, Jesper Hjortdal, Dimitrios Karamichos
Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered. Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea. Hormone levels have been reported to alter corneal thickness, curvature, and sensitivity during different times of menstrual cycle...
May 11, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29757852/comparison-of-corneal-collagen-cross-linking-protocols-measured-with-scheimpflug-tomography
#10
Mehdi Shajari, Gabriela Sowwa, Gernot Steinwender, Christian Hofmann, Marie-Luise Pahlitzsch, Kerstin Petermann, Thomas Kohnen
PURPOSE: To evaluate the effectiveness of corneal collagen cross-linking with Dresden and accelerated protocols to treat keratoconus by Scheimpflug tomography. METHODS: Fifty-eight eyes with manifest keratoconus were measured preoperatively at least twice with the Pentacam. The difference of relevant variables for keratoconus progression (eg, D value, thinnest pachymetry, Kmax) was established. After evident progression, patients underwent corneal cross-linking (29 eyes with the Dresden protocol and 29 eyes with the accelerated protocol)...
May 1, 2018: Cornea
https://www.readbyqxmd.com/read/29753555/evaluation-of-early-postoperative-ocular-pain-after-photorefractive-keratectomy-and-corneal-crosslinking
#11
Siamak Zarei-Ghanavati, Soheyla Jafarpour, Alireza Radyn-Majd, Hamed Hosseinikhah-Manshadi
PURPOSE: To evaluate and compare early postoperative pain after photorefractive keratectomy (PRK) and corneal crosslinking (CXL). SETTING: Khatam-al-Anbia Eye Hospital, Mashhad, Iran. DESIGN: Prospective case series. METHODS: The PRK group included patients with simple refractive errors whereas the CXL group included patients with clinical keratoconus. The groups were compared regarding the level of pain based on the visual analogue scale (VAS), verbal rating scale (VRS), and Wong-Baker FACES pain rating scale immediately after surgery, 6 hours postoperatively, and 1, 3, and 7 days postoperatively...
May 9, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29750946/prevalence-and-incidence-of-keratoconus-in-south-korea-a-nationwide-population-based-study
#12
Sungsoon Hwang, Dong Hui Lim, Tae-Young Chung
PURPOSE: To determine the prevalence and incidence of keratoconus in South Korea. DESIGN: A nationwide, population-based, retrospective study of keratoconus in the entire South Korean population (n=47,990,761) from 2009 to 2014 was conducted using data from the Korean Health Insurance Review and Assessment (HIRA) database. METHODS: We identified patients with ophthalmologist-confirmed keratoconus using the HIRA database, and estimated keratoconus prevalence and incidence rates both overall and according to age and sex...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750010/comparative-analysis-of-safety-and-efficacy-of-photorefractive-keratectomy-versus-photorefractive-keratectomy-combined-with-crosslinking
#13
Gitansha Shreyas Sachdev, Shreyas Ramamurthy, Ramamurthy Dandapani
Purpose: To assess the safety, efficacy, and refractive predictability of half-fluence accelerated corneal collagen crosslinking (CXL) applied concurrently with photorefractive keratectomy (PRK), and compare the results to standard PRK. Setting: Refractive Services, The Eye Foundation, Coimbatore, India. Design: Interventional comparative case series. Methods: Patients seeking refractive correction for myopia or myopic astigmatism were included in the study...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29749994/simultaneous-presence-of-macular-corneal-dystrophy-and-retinitis-pigmentosa-in-three-members-of-a-family
#14
Farhad Nejat, Hossein Aghamollaei, Shiva Pirhadi, Khosrow Jadidi, Mohammad Amin Nejat
Macular corneal dystrophy (MCD) is an autosomal recessive hereditary disease. In most cases, various mutations in carbohydrate sulfotransferase 6 (CHST6) gene are the main cause of MCD. These mutations lead to a defect in keratan sulfate synthesis. Retinitis pigmentosa (RP) is another eye disorder with nyctalopia as its common symptom. It has been shown that more than 65 genes have been implicated in different forms of RP. Herein, we report on a 9-member family with 2 girls and 5 boys. Both parents, one of the girls and one of the boys had normal eye vision and another boy had keratoconus...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29746325/corneal-cross-linking-in-pediatric-patients-evaluating-treated-and-untreated-eyes-5-year-follow-up-results
#15
Lior Or, Assaf Rozenberg, Adi Abulafia, Isaac Avni, David Zadok
PURPOSE: To evaluate the long-term results of corneal collagen cross-linking (CXL) for treatment of pediatric keratoconus and the long-term outcomes of the fellow untreated keratoconic eye in patients younger than 18 years old. METHODS: A retrospective case analysis was performed on 88 eyes of 44 patients aged 18 years or younger, with keratoconus, who underwent CXL in at least 1 eye. Follow-up measurements, for the treated and untreated eye pair, taken up to 5 years after treatment, were compared with baseline values...
May 3, 2018: Cornea
https://www.readbyqxmd.com/read/29738594/bilateral-asymmetric-keratoconus-induced-by-thyrotoxicosis-with-long-term-stability-after-corneal-cross-linking
#16
Ramon Lee, Ahmed El-Massry, Youssef El-Massry, J Bradley Randleman
PURPOSE: To present a case of bilateral, asymmetric keratoconus presenting unilaterally after partial thyroidectomy with delayed presentation in the second eye after thyrotoxicosis, with disease stabilization following corneal cross-linking (CXL). METHODS: Case report and literature review. RESULTS: A 17-year-old girl with a history of Graves' disease underwent partial thyroidectomy without thyroid hormone replacement therapy with normal baseline ophthalmic examination of corrected distance visual acuity (CDVA) of 20/20 and no manifest astigmatism in either eye...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29738593/bilateral-keratoconus-induced-by-secondary-hypothyroidism-after-radioactive-iodine-therapy
#17
Ramon Lee, Farhad Hafezi, J Bradley Randleman
PURPOSE: To present a case of new-onset, bilateral, rapidly progressive keratoconus induced by secondary hypothyroidism after radioactive iodine therapy during the sixth decade of life that was successfully treated with corneal cross-linking. METHODS: Case report and literature review. RESULTS: A 53-year-old woman with no ocular complaints but with a history of Graves' disease and thyrotoxicosis was treated with radioactive iodine therapy and oral levothyroxine for secondary acquired hypothyroidism 3 years prior...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29738584/corneal-allogenic-intrastromal-ring-segments-cairs-combined-with-corneal-cross-linking-for-keratoconus
#18
Soosan Jacob, Shaila R Patel, Amar Agarwal, Arvind Ramalingam, A I Saijimol, John Michael Raj
PURPOSE: To describe a new technique for the treatment of keratoconus using corneal allogenic intrastromal ring segments (CAIRS). METHODS: CAIRS trephined from donor cornea using a double-bladed trephine were implanted into mid-depth femtosecond laser-dissected channels in the cornea of patients with keratoconus in the 6.5-mm optic zone, followed by accelerated corneal cross-linking (A-CXL)-either conventional or contact lens-assisted CXL (A-CACXL), depending on minimum corneal thickness...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29738582/erratum-for-the-relationship-between-mechanical-properties-ultrastructural-changes-and-intrafibrillar-bond-formation-in-corneal-uva-riboflavin-cross-linking-treatment-for-keratoconus
#19
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29736691/comparison-of-pain-after-subepithelial-versus-conventional-accelerated-corneal-collagen-cross-linking-for-keratoconus
#20
Shaowei Li, Huatao Xie, Man Xu, Meiyan Li, Chang Liu, Jingliang He, Tian Han, Xingtao Zhou
PURPOSE: To compare the postoperative pain and epithelial healing time in conventional and subepithelial accelerated corneal collagen cross-linking (CXL) for progressive keratoconus. METHODS: The medical records of 27 consecutive patients who underwent accelerated CXL for progressive keratoconus were retrospectively reviewed. Patients were divided into two groups: the conventional (n = 16) and the subepithelial accelerated CXL group (n = 11). Corneal epithelial layers with a diameter of 8...
May 7, 2018: International Ophthalmology
keyword
keyword
3378
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"