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Keratoconus

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https://www.readbyqxmd.com/read/27900926/-corneal-cross-linking-as-a-treatment-for-progressive-keratoconus
#1
R P L Wisse, N Soeters, D A Godefrooij, N G de Koning-Tahzib
Keratoconus is a corneal disease with onset typically occurring during puberty or early adulthood. The cornea progressively thins and acquires a cone-like shape which negatively affects visual acuity. In the early stages, visual acuity can be corrected with glasses or contact lenses. In more advanced cases, a corneal transplant is ultimately indicated to restore visual acuity. Corneal cross-linking (CXL) is a treatment given at a relatively early stage that protects patients against deterioration of visual acuity and further corneal deformation in progressive cases of keratoconus...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27899371/refractive-improvements-and-safety-with-topography-guided-corneal-crosslinking-for-keratoconus-1-year-results
#2
Maria Nordström, Maria Schiller, Anneli Fredriksson, Anders Behndig
PURPOSE: To assess the refractive improvements and the corneal endothelial safety of an individualised topography-guided regimen for corneal crosslinking in progressive keratoconus. METHODS: An open-label prospective randomised clinical trial was performed at the Department of Clinical Sciences, Ophthalmology, Umeå University Hospital, Umeå, Sweden. Thirty-seven patients (50 eyes) with progressive keratoconus planned for corneal crosslinking were included. The patients were randomised to topography-guided crosslinking (photorefractive intrastromal crosslinking (PiXL); n=25) or uniform 9 mm crosslinking (corneal collagen crosslinking (CXL); n=25)...
November 29, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27897442/pupillary-offset-in-keratoconus-and-its-relationship-with-clinical-and-topographical-features
#3
Gozde Hondur, Nurullah Cagil, Ozge Sarac, Meltem Ece Ozcan, Pinar Kosekahya
PURPOSE: To evaluate the change in the location of pupillary center with corneal tomography in keratoconic patients, and determine the correlation of pupillary offset with clinical and topographical features of keratoconus. METHODS: Ninety-one eyes of the 54 patients with keratoconus in different stages and 39 eyes of 39 refractive surgery candidates with normal corneas were included in our study. Ocular aberrations and the pupillary offset parameters (x-offset and y-offset) over a 5 mm (undilated) pupil were measured with a Sirius corneal tomographer...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27895364/a-10-year-review-of-indications-for-penetrating-keratoplasty-in-a-tertiary-care-setting-in-karachi-pakistan
#4
Tanveer Ajum Chaudhry, Salman Naveed Sadiq, Zubaida Sirang, Maheen Akhtar Syed, Mustafa Kamal, Khabir Ahmad
The retrospective study was conducted to determine the indications and outomes of penetrating keratoplasty(PKP) in a tertiary care setting in Pakistan. All eyes that had undergone PKP between January 2005 and December 2014 at the Aga Khan University Hospital, Karachi, were included.Data were collected on the indications of PKP, graft survival (graft clarity at final follow-up), andbest corrected visual acuity (BCVA).Kaplan-Meier\'s method was usedto analyse graft survival.Out of 437 eyes, 383(87%) were for visual purpose...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27885526/twelve-year-follow-up-of-penetrating-keratoplasty
#5
Takashi Ono, Sosuke Ishiyama, Takeshi Hayashidera, Yosai Mori, Ryohei Nejima, Kazunori Miyata, Shiro Amano
PURPOSE: To evaluate the long-term outcomes of penetrating keratoplasty (PKP) according to the corneal disease diagnosis and the number of PKP procedures performed. METHODS: Five-hundred-and-nine eyes from 403 patients who underwent PKP at Miyata Eye Hospital in Japan from 1998 through 2014, were included in this study. Medical charts were retrospectively examined to ascertain the corneal disease diagnosis and the period of graft survival. Graft survival rates were compared among various corneal disease diagnoses and among the number of PKP procedures performed...
November 24, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27882004/efficacy-and-safety-of-transepithelial-collagen-cross-linking-for-progressive-keratoconus
#6
Sameer Shahid Ameen, Mohammad Asim Mehboob, Kashif Ali
OBJECTIVE: To evaluate the efficacy and safety of transepithelial (TE) collagen cross-linking (CXL) in patients with progressive keratoconus (KC). METHODS: This Quasi Experimental Study was conducted at PNS Shifa Naval Hospital, Karachi from June 2015 to June 2016. Sixty eyes of 32 patients who underwent TE CXL for progressive KC from June 2015 to June 2016 were analysed to ascertain efficacy and safety of TE CXL procedure. Statistical analysis of the data was done using SPSS version 17...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27861309/pilot-study-of-corneal-sensitivity-and-its-association-in-keratoconus
#7
Preeji S Mandathara, Fiona J Stapleton, Jim Kokkinakis, Mark D P Willcox
PURPOSE: To evaluate corneal sensitivity and its association with other clinical parameters in keratoconus. METHODS: Twenty-four subjects with keratoconus aged between 18 and 65 years were recruited in this cross-sectional study. Ocular symptoms, corneal topography, tear variables such as tear osmolarity, volume and lower tear meniscus height, ocular surface staining, central sensitivity threshold (CST), and corneal subepithelial nerve mapping were obtained. Association between central CST and other clinical variables was examined using the Spearman correlation coefficient...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27861308/ocular-surface-disease-parameters-after-collagen-cross-linking-for-keratoconus
#8
José I Recalde, Arantxa Acera, Iñaki Rodríguez-Agirretxe, Miguel A Sánchez-Tena, Juan San-Cristóbal, Juan A Durán
PURPOSE: To analyze the variations in tear quantity and quality after corneal collagen cross-linking (CXL) in patients with keratoconus. METHODS: This is a prospective observational study of 24 eyes with keratoconus that underwent epithelium-off CXL. The variables studied were tear film osmolarity, subjective symptoms (Ocular Surface Disease Index), tear breakup time, Schirmer test (SCH) score, tear clearance, fluorescein staining, and lissamine green staining. Variables were determined preoperatively and 3, 6, and 12 months after CXL...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27861304/trends-in-corneal-transplantation-in-keratoconus
#9
Daniel Sarezky, Stephen E Orlin, Wei Pan, Brian L VanderBeek
PURPOSE: To determine recent trends in and sociodemographic/comorbid conditions associated with penetrating keratoplasty (PK) and lamellar keratoplasty (LK) for keratoconus (KCN). METHODS: Patients with KCN and subsequent PK and LK procedures were identified using International Classification of Diseases, 9th revision (ICD-9) and Current Procedural Terminology (CPT) billing codes. The change in surgical rates was calculated over a decade, and multivariate analysis demonstrated factors associated with undergoing surgery...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27853010/femtosecond-laser-assisted-deep-anterior-lamellar-keratoplasty-with-big-bubble-technique-for-keratoconus
#10
Yan Lu, Xiangfei Chen, Liping Yang, Chunyan Xue, Zhenping Huang
PURPOSE: The purpose of this study was to evaluate the clinical results after deep anterior lamellar keratoplasty (DALK) assisted by the femtosecond laser with big-bubble technique for keratoconus. METHODS: A case series of 22 eyes in 19 patients with keratoconus was enrolled in the study. The 500-kHz VisuMax femtosecond laser (Carl Zeiss Meditec AG, Jena, Germany) was used to create a vertical side cut on donor and recipient corneas. Intraoperative and postoperative complications, uncorrected visual acuity, best-corrected visual acuity, corneal curvature, and central corneal thickness were evaluated in all patients...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27843234/progressive-keratoconus-retinal-detachment-and-intracorneal-silicone-oil-with-obsessive-compulsive-eye-rubbing
#11
Kartik Panikkar, George Manayath, Revathi Rajaraman, Veerappan Saravanan
An 18-year-old boy with an obsessive-compulsive disorder of eye rubbing presented with forme fruste keratoconus (KC) and posterior subcapsular cataracts. After evaluation, he underwent phacoemulsification in his left eye with intraocular lens implantation. The aggressive eye rubbing, however, aggravated the rapid progression to established KC, and further acute corneal hydrops within 3 months. Within the next 3 months, the eye rubbing precipitated rhegmatogenous retinal detachments (RDs) in both eyes. Furthermore, after undergoing a combined cataract and RD surgery with belt buckling and silicone oil endotamponade in his right eye, the repeated eye rubbing caused extrusion of the implanted silicone oil into the subconjunctival space and within the corneal stroma...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27843086/measurement-of-visual-function-among-patients-undergoing-corneal-transplantation-using-the-vf-14-index-in-morocco
#12
S Belghmaidi, L Adarmouch, M Baali, M Sebbani, I Hajji, M Amine, A Moutaouakil
OBJECTIVE: To validate the Moroccan version of the VF-14 in candidates for keratoplasty and to assess their quality of life using this tool before and after transplantation. METHODS: This is a longitudinal prospective study that assessed 57 patients who underwent penetrating keratoplasty, recruited in the ophthalmology service in Marrakech over 5 years. The original VF-14 questionnaire was adapted into Moroccan dialect. The questionnaire was administered before and 2 years after transplantation...
November 11, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27830203/corneal-aberration-changes-after-rigid-gas-permeable-contact-lens-wear-in-keratokonic-patients
#13
Fereshteh Shokrollahzadeh, Hassan Hashemi, Ebrahim Jafarzadehpur, Ali Mirzajani, Mehdi Khabazkhoob, Abbasali Yekta, Soheila Asgari
PURPOSE: To determine the short-term effect of rigid gas permeable (RGP) contact lenses on corneal aberrations in keratoconic patients. METHOD: Sixteen keratoconic eyes with no history of RGP lens wear were included. They all had corneal aberrometry using Pentacam, and different aberration indices of the anterior and posterior surfaces of the cornea were measured before and 3 months after fitting RGP lenses. The effect of baseline parameters on these changes was tested in univariate and multiple models...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27824380/double-pass-retina-point-imaging-for-the-evaluation-of-optical-light-scatter-retinal-image-quality-and-staging-of-keratoconus
#14
Anthony P Leonard, Scott D Gardner, Karolinne M Rocha, Evan R Zeldin, David M Tremblay, George O Waring
PURPOSE: To measure retinal image quality using point spread function (PSF) analysis by double-pass retina point imaging in patients with keratoconus and to correlate visual quality with disease severity. METHODS: Patients diagnosed as having keratoconus by clinical examination, topography, and tomography and normal eyes were included in this study. A commercially available double-pass retina point imaging instrument (OQAS 108 II AcuTarget HD; Visiometrics S.L., Terrassa, Spain) was used to collect Objective Scatter Index (OSI) values in 21 keratoconic and 22 normal eyes...
November 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27819784/-prognostic-category-of-corneal-transplantation-in-a-referal-center
#15
Karla Verdiguel-Sotelo, Arturo Carrasco-Quiroz, Josué Rangel-Servín
BACKGROUND: Penetrating keratoplasty is considered the most frequent and successfully performed organ transplantation. Indications of corneal transplantation have changed over time and they vary according to the country. Some risk factors for graft rejection, as age, corneal vascularization or ocular surgery, among others, have been identified. The aim was to identify the prognostic category, group and associated risk factors of patients registered in the database of corneal transplantation in the Centro Médico Nacional La Raza between 2011 and 2013...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27819732/novel-visual-system-homeobox-1-gene-mutations-in-turkish-patients-with-keratoconus
#16
H Bardak, M Gunay, E Yildiz, Y Bardak, B Gunay, H Ozbas, O Bagci
The aim of this study was to screen the visual system homeobox 1 (VSX1) gene in Turkish patients with keratoconus (KC). The patient group consisted of 44 patients who had undergone corneal transplant surgery before the age of 30, for advanced and rapidly progressive KC. The control group comprised 250 healthy individuals. We detected two missense mutations, D144N and D295Y, in exon 2 and exon 5 of the VSX1 gene, respectively, using next-generation sequencing analysis. The pathologic effects of the D144N and D295Y missense mutations on protein function were determined with bioinformatic analysis tools, SIFT, PolyPhen, and MutationTaster...
November 3, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27815790/keratoconus-and-other-corneal-diseases-pharmacologic-cross-linking-and-future-therapy
#17
Kimberly M Hsu, Joel Sugar
The ability to cross-link collagen fibers and use this technique to strengthen the cornea has become of great interest to ophthalmologists in the last decade. For progressive diseases such as keratoconus, collagen cross-linking confers the possibility of halting progression and stabilizing the cornea, a benefit that is not observed with any other current treatment. Collagen cross-linking uses riboflavin combined with ultraviolet A light to induce the formation of bonds between collagen fibrils that strengthen the cornea...
November 5, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27815340/george-critchett-1817-1882-and-his-son-george-anderson-critchett-1845-1925-two-gifted-english-ocular-surgeons
#18
Konstantinos Laios, Marilita M Moschos, George Androutsos
George Critchett (1817-1882) and his son George Anderson Critchett (1845-1925) have influenced the development of ophthalmology and ocular surgery for about a century. They presented new ocular operations such as Critchett's advancement operation, Critchett's corneal staphyloma operation, and Critchett's keratoconus operation, and they invented new surgical instruments such as Critchett's cataract knife, Critchett's scissors, and Critchett's fixation forceps. Both were delicate ocular surgeons managing complex and difficult surgeries...
November 3, 2016: Surgical Innovation
https://www.readbyqxmd.com/read/27805532/visual-rehabilitation-after-penetrating-keratoplasty
#19
Leyla Asena, Dilek D Altınörs
OBJECTIVES: Here, our aim was to report our treatment strategies and their results performed for visual rehabilitation after penetrating keratoplasty. MATERIALS AND METHODS: The medical records of 98 patients (54 male/44 female), with results from 104 eyes, who underwent penetrating keratoplasty between January 2013 and January 2015 at the Baskent University Faculty of Medicine, Department of Ophthalmology were reviewed. Patient age, indication for penetrating keratoplasty, interventions performed for visual rehabilitation, follow-up duration, topographic and refractive astigmatism at the end of follow-up, and final best corrected visual acuity results were recorded...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27805316/comparison-of-corneal-measurements-in-keratoconus-using-swept-source-optical-coherence-tomography-and-combined-placido-scheimpflug-imaging
#20
Tommy C Y Chan, Sayantan Biswas, Marco Yu, Vishal Jhanji
PURPOSE: The aim of this study was to provide a comprehensive comparison of reliability of corneal topographic measurements in keratoconic eyes using swept-source optical coherence tomography (OCT) and a combined Placido-Scheimpflug imaging. METHODS: A total of 30 eyes of 30 patients were included. The mean age was 31.2 ± 8.4 years. Two consecutive topographic measurements were obtained for one eye of each patient using swept-source OCT (CASIA) and combined Placido-Scheimpflug imaging (TMS-5)...
November 2, 2016: Acta Ophthalmologica
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