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Keratoconus

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https://www.readbyqxmd.com/read/29160595/advanced-anterior-segment-imaging-in-keratoconus-a-review
#1
REVIEW
Akilesh Gokul, Hans R Vellara, Dipika V Patel
Advances in anterior segment imaging have enhanced our ability to detect keratoconus in its early stages and characterise the pathologic changes that occur. Computerised corneal tomography has elucidated the alterations in shape of the anterior and posterior corneal surfaces and alterations in thickness as the disease progresses. Automated screening indices such as the keratoconus screening index were developed to assist in detecting keratoconus in suspicious cases. In vivo assessment of keratoconic corneas has revealed that compromised corneal biomechanics can now be measured clinically...
November 21, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29158547/keratoconus-detection-based-on-a-new-corneal-volumetric-analysis
#2
Francisco Cavas-Martínez, Laurent Bataille, Daniel G Fernández-Pacheco, Francisco J F Cañavate, Jorge L Alio
There are numerous tomographic indices for the detection of keratoconus risk. When the indexes based on corneal volume are analyzed, two problems are presented: on the one hand, they are not very sensitive to the detection of incipient cases of keratoconus because they are not locally defined in the primary developmental region of the structural abnormalities; and on the other hand, they do not register the geometric decompensation driven by the asymmetry present during the disease progression. This work performed a morphogeometric modeling of the cornea by the aid of CAD tools and using raw topographic data (Sirius system, CSO, Firenze)...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142546/comparison-of-analgesic-effect-of-preoperative-topical-diclofenac-versus-ketorolac-on-postoperative-pain-after-corneal-collagen-cross-linkage
#3
Murtaza Sameen, Muhammad Saim Khan, Asad Habib, Muhammad Amer Yaqub, Mazhar Ishaq
Objective: To compare post-operative pain relieving effect of topical diclofenac 0.1% versus ketorolac 0.5% in Corneal Collagen Cross Linking (CXL) for patients diagnosed with keratoconus. Methods: This randomized controlled trial was carried out for six months from October 2016 to March 2017. We included young patients having keratoconus with k-readings greater than 47D and central corneal thickness more than 400 microns. All the patients received single dose one drop of topical diclofenac 0...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29137083/indications-and-outcomes-of-pediatric-keratoplasty-in-a-tertiary-eye-care-center-a-retrospective-review
#4
Rosario Gulias-Cañizo, Roberto Gonzalez-Salinas, Luis Fernando Hernandez-Zimbron, Everardo Hernandez-Quintela, Valeria Sanchez-Huerta
To evaluate indications and outcomes of pediatric keratoplasty in a tertiary eye center, and identify factors that affect visual outcomes.We performed a retrospective review of penetrating keratoplasty in children aged 0 to 18 years between 1995 and 2011 in the Asociación para Evitar la Ceguera en México IAP, Hospital "Dr. Luis Sánchez Bulnes".A total of 574 penetrating keratoplasties were performed during the study interval. Median follow-up was 5.0 years. Main indications included keratoconus (55.58%), postherpetic scarring (9...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135710/adjustment-of-intrastromal-corneal-ring-segments-after-unsuccessful-implantation-in-keratoconic-eyes
#5
Tiago Monteiro, José Ferreira Mendes, Fernando Faria-Correia, Nuno Franqueira, David Madrid-Costa, José F Alfonso
PURPOSE: To evaluate visual, refractive, and corneal topography outcomes in eyes with keratoconus that have undergone exchange/adjustment surgery with a new intrastromal corneal ring segment (ICRS) combination after unsuccessful visual and/or refractive outcomes after primary ICRS surgery. METHODS: A retrospective nonrandomized case series was conducted including consecutive eyes of patients with keratoconus that underwent ICRS adjustment after an unsuccessful visual outcome...
November 13, 2017: Cornea
https://www.readbyqxmd.com/read/29133974/higher-order-optical-aberrations-and-visual-acuity-in-a-randomized-controlled-trial-comparing-transepithelial-versus-epithelium-off-corneal-crosslinking-for-progressive-keratoconus
#6
Daniel A Godefrooij, Mustapha El Kandoussi, Nienke Soeters, Robert Pl Wisse
Purpose: The purpose of this study was to compare the effects of transepithelial crosslinking (trans-CXL) versus epithelium-off crosslinking (epi-off CXL) for progressive keratoconus with respect to the development of higher order aberrations (HOAs) and their effects on visual acuity. Materials and methods: A total of 61 patients were randomized and examined preoperatively and 1, 3, 6, and 12 months postoperatively in an academic referral center. Total corneal HOAs were compared between the two treatment groups using mixed linear modeling...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29133633/altered-tear-inflammatory-profile-in-indian-keratoconus-patients-the-2015-col-rangachari-award-paper
#7
Rohit Shetty, Rashmi Deshmukh, Arkasubhra Ghosh, Swaminathan Sethu, Chaitra Jayadev
PURPOSE: Conventionally, keratoconus (KC) has been considered a noninflammatory corneal ectatic disorder. Recent evidence suggests a possible role of inflammation in the pathogenesis of KC. Hence, we analyzed the levels of inflammatory factors in the tear fluid of Indian KC patients. METHODS: Tear fluid samples were collected from age- and sex-matched healthy controls and KC patients (with different grades). The levels of the inflammatory factors in tears were analyzed using cytometric bead array (Human Soluble Protein Flex Set System, BD Biosciences) for levels of interleukin-1α (IL-1α), IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12p70, IL-23p40, IL-13, IL-17A, IL-17F, IL-21, interferon-α (IFNα), IFNγ, tumor necrosis factor-α, CCL2/monocyte chemotactic protein-1, CCL4/macrophage inflammatory protein-1β (MIP-1β), MIP-1α, CCL5/RANTES, CXCL10/IP10, ICAM1, CD62E, vascular endothelial growth factor and transforming growth factor β...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133627/altered-tear-inflammatory-profile-in-indian-keratoconus-patients
#8
EDITORIAL
Prashant Garg
No abstract text is available yet for this article.
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29124079/identifying-more-reliable-parameters-for-the-detection-of-change-during-the-follow-up-of-mild-to-moderate-keratoconus-patients
#9
Ivo Guber, Colm McAlinden, François Majo, Ciara Bergin
Background: Reaching a consensus on which parameters are most reliable at detecting progressive keratoconus patients with serial topography imaging is not evident. The aim of the study was to isolate the parameters best positioned to detect keratoconus progression using the Pentacam HR® measures based on the respective limits of repeatability and range of measurement. Method: Using the Pentacam HR®, a tolerance index was calculated on anterior segment parameters in healthy and keratoconic eyes...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/29123375/sequential-keraring-implantation-and-corneal-cross-linking-for-the-treatment-of-keratoconus-in-children-with-vernal-keratoconjunctivitis
#10
Mortada A Abozaid
Purpose: The purpose of this study was to assess the safety and efficacy of femtosecond laser-assisted Keraring implantation followed by transepithelial accelerated corneal collagen cross-linking (CXL) for the treatment of keratoconus in children with vernal keratoconjunctivitis (VKC). Study design: This is a prospective interventional non-comparative case series. Patients and methods: Eighteen eyes of 11 children with keratoconus and VKC were included in this study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29122823/comparative-evaluation-of-progression-rate-in-keratoconus-before-and-after-collagen-crosslinking
#11
Yu Meng Wang, Tommy Cy Chan, Marco C Y Yu, Vishal Jhanji
PURPOSE: To compare the rate of disease progression in keratoconus before and after corneal collagen crosslinking (CXL). METHODS: 145 eyes were followed without CXL (no-CXL group) for a median duration of 31 months whereas 45 eyes were followed up for 41 months before (pre-CXL) and after (post-CXL) accelerated, epithelium-off crosslinking. Progression was defined based on significant slope found in linear mixed effect models against time. Swept-source optical coherence tomography was used for measurement of anterior steep keratometry, anterior flat keratometry (Ant Kf), anterior average keratometry (Ant Avg K); posterior steep keratometry, posteriorflat keratometry (Post Kf), posterior average keratometry (Post Avg K) and corneal thickness...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29122822/posterior-keratoconus
#12
REVIEW
Megan R Silas, Sarah M Hilkert, James J Reidy, Asim V Farooq
Posterior keratoconus (PKC) is a rare, typically non-inflammatory condition that is characterised by an abnormal posterior corneal curvature, which may be accompanied by overlying stromal opacification. It is usually congenital and can be associated with other ocular and systemic abnormalities. PKC remains a clinical diagnosis, although imaging techniques including ultrasound biomicroscopy and anterior segment optical coherence tomography may be useful tools for confirmation and classification. Genetic studies should be considered, although no specific genetic defects have been identified thus far...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29121878/comparison-of-femtosecond-laser-assisted-corneal-intrastromal-xenotransplantation-and-the-allotransplantation-in-rhesus-monkeys
#13
He Jin, Liangping Liu, Hui Ding, Miao He, Chi Zhang, Xingwu Zhong
BACKGROUND: In our previous study, we showed that both allogeneic and autogeneic small-incision femtosecond laser-assisted corneal intrastromal transplantation are safe and effective surgeries. However, the results of small-incision femtosecond laser-assisted intrastromal xenotransplantation have not yet been explored. Additionally, we suggest that glycerol-dehydrated corneal lamellae might provide a possible alternative for this xenogenic implantation approach. METHODS: Corneal inlay lamellae were produced from rabbits and humans using femtosecond laser-assisted surgeries and were dehydrated in glycerol for 1 week at 4 °C...
November 9, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29120715/new-pinhole-sulcus-implant-for-the-correction-of-irregular-corneal-astigmatism
#14
Claudio C Trindade, Bruno C Trindade, Fernando C Trindade, Liliana Werner, Robert Osher, Marcony R Santhiago
PURPOSE: To evaluate the effect on visual acuity of the implantation of a new intraocular pinhole device (Xtrafocus) in cases of irregular corneal astigmatism with significant visual impairment. SETTING: University of São Paulo, São Paulo, Brazil. DESIGN: Prospective case series. METHODS: Pseudophakic eyes of patients with irregular corneal astigmatism were treated with the pinhole device. The causes of irregular corneal astigmatism were keratoconus, post radial keratotomy (RK), post-penetrating keratoplasty (PKP), and traumatic corneal laceration...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29120713/waveform-analysis-of-deformation-amplitude-and-deflection-amplitude-in%C3%A2-normal-suspect-and-keratoconic-eyes
#15
Mathew Francis, Natasha Pahuja, Rushad Shroff, Roshan Gowda, Himanshu Matalia, Rohit Shetty, Everette J Remington Nelson, Abhijit Sinha Roy
PURPOSE: To evaluate the performance of waveform-derived variables in distinguishing normal, suspect, and keratoconic eyes. SETTING: Narayana Nethralaya Eye Hospital, Bangalore, India. DESIGN: Retrospective case series. METHODS: Scheimpflug tomography (Pentacam) and dynamic Scheimpflug analysis (Corvis ST) of 253 normal (253 patients) eyes and 205 keratoconic eyes (205 patients) were evaluated. Among the 205 patients, 62 had keratoconus in 1 eye, while the unaffected eye was suspect...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29120712/demarcation-line-depth-after-contact-lens-assisted-corneal-crosslinking-for%C3%A2-progressive-keratoconus-comparison-of%C3%A2-dextran-based-and-hydroxypropyl-methylcellulose-based-riboflavin-solutions
#16
Chintan Malhotra, Arun K Jain, Amit Gupta, Jagat Ram, Balamurugan Ramatchandirane, Deepika Dhingra, Kulbhushan Sachdeva, Amit Kumar
PURPOSE: To compare the demarcation line depth after contact lens-assisted corneal crosslinking (CXL) for progressive keratoconus using dextran-based and hydroxypropyl methylcellulose (HPMC)-based riboflavin solutions. SETTING: Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India. DESIGN: Retrospective case series. METHODS: Patients with preoperative epithelium-on (epi-on) minimum corneal thickness between 350 μm and 450 μm having contact lens-assisted CXL for progressive keratoconus were crosslinked with isoosmolar 0...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29120711/combined-transepithelial-phototherapeutic-keratectomy-and-conventional-photorefractive-keratectomy-followed-simultaneously-by-corneal-crosslinking-for-keratoconus-cretan-protocol-plus
#17
Michael A Grentzelos, George A Kounis, Vasilios F Diakonis, Charalambos S Siganos, Miltiadis K Tsilimbaris, Ioannis G Pallikaris, George D Kymionis
PURPOSE: To evaluate the visual, refractive, and topographic outcomes after combined transepithelial phototherapeutic keratectomy (PTK) and conventional photorefractive keratectomy (PRK) followed simultaneously by corneal crosslinking (CXL) for keratoconus. SETTING: Vardinoyiannion Eye Institute of Crete, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece. DESIGN: Prospective case series. METHODS: Patients with progressive keratoconus had simultaneous conventional PRK followed by CXL; the corneal epithelium was removed using transepithelial PTK (Cretan protocol plus)...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29120710/femtosecond-laser-implantation-of%C3%A2-a%C3%A2-340-degree-intrastromal-corneal-ring%C3%A2-segment-in-keratoconus-short-term%C3%A2-outcomes
#18
Mohammad Mehdi Sadoughi, Bahram Einollahi, Amir Reza Veisi, Mohammad Zare, Mohammad Reza Sedaghat, Danial Roshandel, Neda Einollahi, Javad Rezaei
PURPOSE: To evaluate the short-term outcomes of femtosecond laser-assisted implantation of a 340-degree intracorneal ring (ICR) (Keraring) in patients with keratoconus. SETTING: Four centers in Iran. DESIGN: Prospective case series. METHODS: All cases had implantation of the 340-degree ICR after tunnel creation with a femtosecond laser. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, sphere, cylinder, manifest refraction spherical equivalent (MRSE), mean keratometry (K), steep K, and flat K were evaluated preoperatively and 1, 3, and 6 months postoperatively...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29118708/corneal-collagen-cross-linking-combined-with-an-artiflex-iris-fixated-anterior-chamber-phakic-intraocular-lens-implantation-in-a-patient-with-progressive-keratoconus
#19
Sharif Hashmani, Nauman Hashmani, Roha Saeed Memon
We present here the case of a 24-year-old male who experienced progressive keratoconus and vision loss which adversely affected his ability to carry out everyday tasks. This landed him in the Hashmanis Hospital for consultation. He had a preoperative best corrected visual acuity of 6/12. He underwent multiple Oculus Pentacam examinations, which showed progressive keratoconus. Corneal collagen cross-linking (CXL) was performed to stabilize his cornea and, subsequently, an Artiflex anterior chamber iris-fixated phakic intraocular lens (ACIF-PIOL) was implanted to alleviate his refractive errors...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29118505/descemet-s-membrane-macroperforation-during-interface-irrigation-in-big-bubble-deep-anterior-lamellar-keratoplasty
#20
Mohammed Ziaei, Susan E Ormonde
This report describes the macroperforation of descemet's membrane (DM) during irrigation of the interface following successful removal of stromal tissue in big bubble (BB) deep anterior lamellar keratoplasty (DALK). A 42-year-old woman with keratoconus underwent a BB DALK procedure. After successful formation of Type 2 bubble and removal of stromal tissue, interface irrigation was performed to remove residual viscoelastic. This led to a macroperforation of DM, and the case was converted to penetrating keratoplasty...
September 2017: Oman Journal of Ophthalmology
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