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https://www.readbyqxmd.com/read/29350802/cellular-reprogramming-a-new-way-to-understand-aging-mechanisms
#1
REVIEW
Burcu Yener Ilce, Umut Cagin, Acelya Yilmazer
Increased life expectancy, due to the rise in life quality and the decline in mortality rates, is leading to a society in which the population aged 60 and over is growing more rapidly than the entire population. Although various models and model organisms have been employed to investigate the mechanism of aging, induced pluripotent stem cells (iPSCs) are useful candidates to study human aging and age-related human diseases. This work discusses how iPSCs can be used as an alternative to the model organisms such as yeast, Caenorhabditis elegans, Drosophila melanogaster, or the mouse...
January 19, 2018: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/29343830/biological-rejuvenation-of-iron-oxides-in-bioturbated-marine-sediments
#2
Jacob P Beam, Jarrod J Scott, Sean M McAllister, Clara S Chan, James McManus, Filip J R Meysman, David Emerson
The biogeochemical cycle of iron is intricately linked to numerous element cycles. Although biological processes that catalyze the reductive side of the iron cycle are established, little is known about microbial oxidative processes on iron cycling in sedimentary environments-resulting in the formation of iron oxides. Here we show that a potential source of sedimentary iron oxides originates from the metabolic activity of iron-oxidizing bacteria from the class Zetaproteobacteria, presumably enhanced by burrowing animals in coastal sediments...
January 17, 2018: ISME Journal
https://www.readbyqxmd.com/read/29334090/supramolecular-photosensitizers-rejuvenate-photodynamic-therapy
#3
Xingshu Li, Songyi Lee, Juyoung Yoon
Owing to its spatiotemporal selectivity and noninvasive nature, photodynamic therapy (PDT) has become a clinically promising approach for the treatment of a wide range of cancers and other diseases. However, the full potential of PDT has not been achieved thus far as a consequence of the lack of optimal photosensitizers (PSs) and/or smart transport/activation strategies. These problems, which unfortunately lie at the core of the PDT paradigm, include the oxygen reliance limits, the effect of PDT on hypoxic tumors, limitations of light penetration, and undesired skin photosensitization induced by "always on" PSs...
January 15, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29321045/stem-cells-and-anti-aging-genes-double-edged-sword-do-the-same-job-of-life-extension
#4
REVIEW
Mujib Ullah, Zhongjie Sun
Aging impacts diseases and lifespan. With current knowledge of stem cells, it is feasible to design and test interventions that delay aging and improve both health and lifespan. Stem cells, together with anti-aging genes such as Klotho, play a crucial role in delaying the aging process. Stem cells in combination with anti-aging genes make a complex and protective shield, which stand against the eroding effects of aging. Increased wear and tear of the stem cells, as well as Klotho deficiency, is expected to heavily increase cellular damage and accelerate the process of aging...
January 10, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29320637/rejuvenating-regenerative-medicine-regulation
#5
R Alta Charo, Douglas Sipp
The Food and Drug Administration (FDA) recently made long-awaited progress toward protecting patients from interventions involving human cell- and tissue-based products (HCT/P) of unknown safety and efficacy. By clarifying its position on the handling and therapeutic use of cells, the agency has..
January 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29320593/injection-depth-in-intradermal-therapy-update-and-correction-of-published-data
#6
Patrick Micheels, Lisa Goodman
BACKGROUND: This paper sought to compare calculated injection depth data with published report claims concerning intradermal therapy and skin rejuvenation of the face, hands, neck, and décolleté. OBJECTIVE: A mathematical formula was employed to assess the injection depth, and data from literature were retrieved and compared with the calculated figures to determine whether the claims about the injection depth proved correct. METHODS: Based on a study by Della Volpe et al...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29320592/injectable-non-animal-stabilized-hyaluronic-acid-as-a-skin-quality-booster-an-expert-panel-consensus
#7
Magda Belmontesi, Francesca De Angelis, Carlo Di Gregorio, Ivano Iozzo, Marina Romagnoli, Giovanni Salti, Matteo Tretti Clementoni
Hyaluronic acid (HA) is used extensively in aesthetic medicine thanks to its documented role in skin rejuvenation. The specific applications of HA-based products are not always fully acknowledged due to a lack of consistent recommendations. In this paper, the authors have summarized available published data on the range of applications of non-animal stabilized hyaluronic acid (NASHA®) gel skin boosters (NSBs) in several anatomical areas and types of patient, as well as their own recommendations. Overall, the panel agreed that a standard initial protocol treatment of up to 3 sessions, followed by a maintenance schedule, would allow patients to improve and then preserve skin quality over time...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29320587/a-randomized-study-to-assess-the-efficacy-of-skin-rejuvenation-therapy-in-combination-with-neurotoxin-and-full-facial-filler-treatments
#8
Steven H Dayan, Thuy-Van T Ho, Jonathan T Bacos, Nimit D Gandhi, Arjun Kalbag, Selika Gutierrez-Borst
<p>BACKGROUND: Although non-surgical treatment options for facial rejuvenation are well-established, the literature remains limited regarding the combined effect of topical skin treatment with filler and neurotoxin on patient appearance and satisfaction. The objectives of this study were to assess the impact of a skin rejuvenation therapy in combination with neurotoxin or hyaluronic acid filler injection on skin quality and general aesthetic improvement as well as on short-term self-esteem.</p> <p>METHODS: From 2015 to 2017, 20 female patients were enrolled in our study and were randomized into two groups...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29315143/predictive-techniques-for-neurotoxin-outcomes
#9
Liza Brown, Drew Taylor, Eduardo Weiss
BACKGROUND: Botulinum-derived neurotoxins have become a substantial tool in dermatologists' armamentarium for facial/neck rejuvenation. Current literature discusses anatomical "danger zones" to avoid during neurotoxin injection to prevent brow ptosis, blepharoptosis, and lower facial ptosis. OBJECTIVE: The aim of this study was to determine whether lidocaine 1% local anesthetic can be used to predict botulinum toxin treatment outcomes and prevent adverse effects of unwanted paralysis...
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29314648/polycaprolactone-facial-volume-restoration-of-a-46-year-old-asian-women-a-case-report
#10
Shang-Li Lin
A 46-year-old Asian women was treated with a next-generation bioresorbable biostimulatory polycaprolactone (PCL)-based dermal filler to restore facial volume loss. Before- and after (12 weeks of follow-up)-treatment photographs were analyzed and compared. In addition, before- and after-treatment contour images were recorded using the Vectra® XT 3D imaging system (Canfield Scientific, Inc.). Improvement of facial volume in multiple tissue layers was observed at 4 and 12 weeks of follow-up. Total facial rejuvenation to correct descending soft tissue with a PCL-based dermal filler was achieved through volume restoration in multiple tissue layers of the face...
January 4, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29311544/silencing-of-the-lncrna-zeb2-nat-facilitates-reprogramming-of-aged-fibroblasts-and-safeguards-stem-cell-pluripotency
#11
Bruno Bernardes de Jesus, Sérgio Pires Marinho, Sara Barros, António Sousa-Franco, Catarina Alves-Vale, Tânia Carvalho, Maria Carmo-Fonseca
Aging imposes a barrier to somatic cell reprogramming through poorly understood mechanisms. Here, we report that fibroblasts from old mice express higher levels of Zeb2, a transcription factor that activates epithelial-to-mesenchymal transition. Synthesis of Zeb2 protein is controlled by a natural antisense transcript named Zeb2-NAT. We show that transfection of adult fibroblasts with specific LNA Gapmers induces a robust downregulation of Zeb2-NAT transcripts and Zeb2 protein and enhances the reprogramming of old fibroblasts into pluripotent cells...
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29309340/role-of-nonsurgical-chin-augmentation-in-full-face-rejuvenation-a-review-and-our-experience
#12
Monique J Vanaman Wilson, Isabela T Jones, Kimberly Butterwick, Sabrina G Fabi
BACKGROUND: The chin is a critical component to the perception of facial attractiveness. Dermal fillers offer a nonsurgical, temporary method of correcting mild to moderate chin retrusion and resorption. Thus far, discussion of this procedure has been largely limited to the plastic surgery and otolaryngology literature. OBJECTIVE: To review pertinent aspects of anatomy, patient evaluation, injection technique, concomitant therapies, and complications in chin augmentation using injectable fillers...
January 5, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29309339/punctuated-88-phenol-peeling-for-the-treatment-of-facial-photoaging-a-clinical-and-histopathological-study
#13
Maria Cristina C de Mendonça, Natália N Segheto, Fernando M Aarestrup, Beatriz J V Aarestrup
BACKGROUND: Phenol peeling is considered an important agent in the treatment of facial rejuvenation; however, its use has limitations due to its high potential for side effects. OBJECTIVE: This article proposes a new peeling application technique for the treatment of photoaging, aiming to evaluate, clinically and histopathologically, the efficacy of a new way of applying 88% phenol, using a punctuated pattern. METHODS: The procedure was performed in an outpatient setting, with female patients, on static wrinkles and high flaccidity areas of the face...
January 5, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29305003/muscle-stem-cells-and-aging
#14
Ara B Hwang, Andrew S Brack
Satellite cells (SCs) are a population of muscle-resident stem cells that are essential for efficient tissue repair. SCs reside in a relatively quiescent state during normal tissue turnover, but are activated in response to injury through the microenvironment and cell-intrinsic signals. During aging, SC dysfunction is a major contributor to the decline in regenerative potential of muscle tissue. Recent studies have demonstrated that both cell-intrinsic and cell-extrinsic factors are deregulated during aging...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29302907/the-effects-of-different-aeration-strategies-on-the-performance-of-constructed-wetlands-for-phosphorus-removal
#15
Huma Ilyas, Ilyas Masih
The effects of different aeration methods such as tidal flow (TF), effluent recirculation (ER), and artificial aeration (AA) on the performance of vertical-flow constructed wetland (VFCW), horizontal-flow constructed wetland (HFCW), and hybrid constructed wetland (HCW) are extensively and critically evaluated in this review paper. Aerated constructed wetlands (CWs) demonstrate superior performance compared with non-aerated systems. The removal of total phosphorus (TP) showed substantial variation among different types of CWs and aeration strategies, with mean and standard deviation of 68 ± 20% estimated from all reviewed studies on aerated systems...
January 4, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29301845/elixir-of-life-thwarting-aging-with-regenerative-reprogramming
#16
REVIEW
Ergin Beyret, Paloma Martinez Redondo, Aida Platero Luengo, Juan Carlos Izpisua Belmonte
All living beings undergo systemic physiological decline after ontogeny, characterized as aging. Modern medicine has increased the life expectancy, yet this has created an aged society that has more predisposition to degenerative disorders. Therefore, novel interventions that aim to extend the healthspan in parallel to the life span are needed. Regeneration ability of living beings maintains their biological integrity and thus is the major leverage against aging. However, mammalian regeneration capacity is low and further declines during aging...
January 5, 2018: Circulation Research
https://www.readbyqxmd.com/read/29296569/effect-of-thread-embedding-acupuncture-for-facial-wrinkles-and-laxity-a-single-arm-prospective-open-label-study
#17
Younghee Yun, Inhwa Choi
Background: There is a growing trend for patients to seek the least invasive treatments with less risk of complications and downtime for facial rejuvenation. Thread embedding acupuncture has become popular as a minimally invasive treatment. However, there is little clinical evidence in the literature regarding its effects. Methods: This single-arm, prospective, open-label study recruited participants who were women aged 40-59 years, with Glogau photoaging scale III-IV...
December 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/29295973/protein-inspired-antibiotics-active-against-vancomycin-and-daptomycin-resistant-bacteria
#18
Mark A T Blaskovich, Karl A Hansford, Yujing Gong, Mark S Butler, Craig Muldoon, Johnny X Huang, Soumya Ramu, Alberto B Silva, Mu Cheng, Angela M Kavanagh, Zyta Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya A Bradford, June C Lee, Tomislav Karoli, Ruby Pelingon, David J Edwards, Maite Amado, Alysha G Elliott, Wanida Phetsang, Noor Huda Daud, Johan E Deecke, Hanna E Sidjabat, Sefetogi Ramaologa, Johannes Zuegg, Jason R Betley, Andrew P G Beevers, Richard A G Smith, Jason A Roberts, David L Paterson, Matthew A Cooper
The public health threat posed by a looming 'post-antibiotic' era necessitates new approaches to antibiotic discovery. Drug development has typically avoided exploitation of membrane-binding properties, in contrast to nature's control of biological pathways via modulation of membrane-associated proteins and membrane lipid composition. Here, we describe the rejuvenation of the glycopeptide antibiotic vancomycin via selective targeting of bacterial membranes. Peptide libraries based on positively charged electrostatic effector sequences are ligated to N-terminal lipophilic membrane-insertive elements and then conjugated to vancomycin...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29287956/mitochondrial-quality-control-the-role-of-mitophagy-in-aging
#19
REVIEW
Ruoyang Shi, Matthew Guberman, Lorrie A Kirshenbaum
Autophagy is a catabolic process for eliminating macromolecules and damaged organelles by a highly regulated lysosomal pathway. Importantly, autophagy serves as an integral quality control mechanism by recycling cellular constituents for energy consumption and cellular rejuvenation under basal and stress conditions. Nevertheless, there is growing evidence that under certain conditions autophagy can switch from an adaptive survival mechanism to maladaptive process that promotes cell death. Furthermore, defects in autophagy have been linked to mitochondria injury and cell death associated with aging...
December 6, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29283463/neck-rejuvenation-by-direct-anterior-medial-cervicoplasty-the-modified-zigzag-plasty-according-to-tschopp
#20
Alexander Konstantinow, Tatjana Fischer, Alexander Zink
BACKGROUND: Conventional cervicofacial rhytidectomy has become the standard treatment of skin excess of the ageing neck. However, some patients want to avoid an extensive surgical procedure, especially if the anterior neck is the predominant problem zone. OBJECTIVE: To report on the efficacy and safety of a zigzag-shaped skin excision combined with platysma plication. METHODS & MATERIALS: We present a retrospective case review series of 6 female patients...
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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