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Rejuvenation

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https://www.readbyqxmd.com/read/28230051/cellular-senescence-mediates-fibrotic-pulmonary-disease
#1
Marissa J Schafer, Thomas A White, Koji Iijima, Andrew J Haak, Giovanni Ligresti, Elizabeth J Atkinson, Ann L Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L Mazula, Robert W Brooks, Heike Fuhrmann-Stroissnigg, Tamar Pirtskhalava, Y S Prakash, Tamara Tchkonia, Paul D Robbins, Marie Christine Aubry, João F Passos, James L Kirkland, Daniel J Tschumperlin, Hirohito Kita, Nathan K LeBrasseur
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung tissue and senescent cell deletion rejuvenates pulmonary health in aged mice. Whether and how senescent cells regulate IPF or if their removal may be an efficacious intervention strategy is unknown. Here we demonstrate elevated abundance of senescence biomarkers in IPF lung, with p16 expression increasing with disease severity...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28229524/dermal-morphological-changes-following-salicylic-acid-peeling-and-microdermabrasion
#2
Amira A Abdel-Motaleb, Eman E Abu-Dief, Mahmoud Ra Hussein
BACKGROUND: Microdermabrasion and chemical peeling are popular, inexpensive, and safe methods for treatment of some skin disorders and to rejuvenate skin. OBJECTIVES: To study the alterations of the dermal connective tissue following salicylic acid peeling and microdermabrasion. METHODS: Twenty patients were participated in our study. All participants underwent facial salicylic acid 30% peel or microdermabrasion (10 cases in each group) weekly for 6 weeks...
February 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28229284/prolonged-growth-hormone-insulin-insulin-like-growth-factor-nutrient-response-signaling-pathway-as-a-silent-killer-of-stem-cells-and-a-culprit-in-aging
#3
REVIEW
Mariusz Z Ratajczak, Andrzej Bartke, Zbigniew Darzynkiewicz
The dream of slowing down the aging process has always inspired mankind. Since stem cells are responsible for tissue and organ rejuvenation, it is logical that we should search for encoded mechanisms affecting life span in these cells. However, in adult life the hierarchy within the stem cell compartment is still not very well defined, and evidence has accumulated that adult tissues contain rare stem cells that possess a broad trans-germ layer differentiation potential. These most-primitive stem cells-those endowed with pluripotent or multipotent differentiation ability and that give rise to other cells more restricted in differentiation, known as tissue-committed stem cells (TCSCs) - are of particular interest...
February 22, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28226378/mandibular-rim-trilogy-with-botulinum-toxin-injection-reduction-projection-and-lift
#4
Renpeng Zhou, Benyun Pan, Chen Wang, Danru Wang
"Onabotulinum toxin A (Botox) revolution" has brought the fundamental change in the facial rejuvenation as well as the concept of microinjection. The aesthetic standard tends to be the "globalization"; however, Asians have different aesthetic cultures and unique facial features compared with Caucasians. A new rejuvenation concept is proposed during our practice; the Asian face should preserve the original facial identity during Botox treatments. The lower face is treated with botulinum toxin to achieve a harmonious facial profile...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226236/new-strategies-and-tools-in-quantitative-genetics-how-to-go-from-the-phenotype-to-the-genotype
#5
C Bazakos, M Hanemian, C Trontin, J M Jiménez-Gómez, O Loudet
Quantitative genetics has a long history in plants: It has been used to study specific biological processes, identify the factors important for trait evolution, and breed new crop varieties. These classical approaches to quantitative trait locus mapping have naturally improved with technology. In this review, we show how quantitative genetics has evolved recently in plants and how new developments in phenotyping, population generation, sequencing, gene manipulation, and statistics are rejuvenating both the classical linkage mapping approaches (for example, through nested association mapping) as well as the more recently developed genome-wide association studies...
February 6, 2017: Annual Review of Plant Biology
https://www.readbyqxmd.com/read/28224997/clonal-reversal-of-ageing-associated-stem-cell-lineage-bias-via-a-pluripotent-intermediate
#6
Martin Wahlestedt, Eva Erlandsson, Trine Kristiansen, Rong Lu, Cord Brakebusch, Irving L Weissman, Joan Yuan, Javier Martin-Gonzalez, David Bryder
Ageing associates with significant alterations in somatic/adult stem cells and therapies to counteract these might have profound benefits for health. In the blood, haematopoietic stem cell (HSC) ageing is linked to several functional shortcomings. However, besides the recent realization that individual HSCs might be preset differentially already from young age, HSCs might also age asynchronously. Evaluating the prospects for HSC rejuvenation therefore ultimately requires approaching those HSCs that are functionally affected by age...
February 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28221181/lower-facial-rejuvenation-using-absorbable-casting-barbed-thread
#7
Woon Il Baek, Woo Seob Kim, Joon Hyuk Suh, Beom Joon Kim
No abstract text is available yet for this article.
February 17, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28216812/midface-lift-patient-satisfaction-a-5-year-follow-up-study
#8
Michele Pascali, Davide Quarato, Ilaria Bocchini, Valerio Cervelli
CONTEXT: Several studies showed, from the clinical point of view, the advantages of the various techniques and surgical approaches to obtain facial rejuvenation. A few studies have highlighted the satisfaction or not of patients who underwent a traditional facelift; however, a long-term follow-up study measuring patient satisfaction with midface-lift surgery has not been published yet. AIMS: The aim of this study is to measure individual patient satisfaction with the midface lift, to find out from each patient his/her level of satisfaction 1 and 5 years after the operation and to compare the results to assess the benefits of the surgery...
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28215619/the-effect-of-aging-on-the-three-dimensional-aspect-of-the-hand-a-pilot-study
#9
I A Hoevenaren, T S Wesselius, J W Meulstee, R D Vreeken, T J J Maal, D J O Ulrich
BACKGROUND: With the increasing popularity of rejuvenation treatments of the skin, there has been an increase in patient inquiry for rejuvenation of the hand. Thus far, no imaging tool exists to analyze the aging process of the hand. Three-dimensional (3D) stereophotogrammetry is a reliable technique, which is used for other purposes in soft tissue analysis of the upper extremity. This pilot study aimed to investigate the possibility of visualizing the hand aging process by 3D stereophotogrammetry...
January 8, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28207035/aesthetic-rejuvenation-of-the-face-and-neck
#10
Janek Januszkiewicz
No abstract text is available yet for this article.
March 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28198772/micro-free-orbital-fat-grafts-to-the-tear-trough-deformity-during-lower-blepharoplasty
#11
Suzette G Miranda, Mark A Codner
BACKGROUND: The tear trough deformity is challenging in lower eyelid rejuvenation. Surgical treatment has evolved with more modern techniques preserving orbital fat and using autologous fat transposition. The author reviewed his own experience in targeting the tear trough in lower lid blepharoplasty and presented a new technique that incorporates the addition of micro free fat grafts which adds direct volume to the underlying anatomical depression using a transcutaneous skin-muscle approach...
February 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28194350/changes-in-eyebrow-position-and-movement-with-aging
#12
Jeongseob Park, Sangho Yun, Daegu Son
BACKGROUND: This study evaluated dynamic changes in eyebrow position related to aging. METHODS: Female participants were recruited and separated into two groups aged 20-30 years (the younger group, n=20; mean age, 24.8 years) and 50-70 years (the older group, n=20; mean age, 55.8 years). Photogrammetry was used to determine the eyebrow position at the medial canthus (MC), lateral limbus, lateral canthus, and lateral end point (EP) for 6 actions: smooth opening (the reference action) and closing of the eye, forward gaze, maximum opening and closing of the eye, and maximum frown...
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28193623/restricted-access-spatial-sequestration-of-damaged-proteins-during-stress-and-aging
#13
REVIEW
Sandra Malmgren Hill, Sarah Hanzén, Thomas Nyström
The accumulation of damaged and aggregated proteins is a hallmark of aging and increased proteotoxic stress. To limit the toxicity of damaged and aggregated proteins and to ensure that the damage is not inherited by succeeding cell generations, a system of spatial quality control operates to sequester damaged/aggregated proteins into inclusions at specific protective sites. Such spatial sequestration and asymmetric segregation of damaged proteins have emerged as key processes required for cellular rejuvenation...
February 13, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28190758/intercellular-signalling-cross-talk-to-kill-to-heal-and-to-rejuvenate
#14
REVIEW
Egor Y Plotnikov, Denis N Silachev, Vasily A Popkov, Ljubava D Zorova, Irina B Pevzner, Savva D Zorov, Stanislovas S Jankauskas, Valentina A Babenko, Gennady T Sukhikh, Dmitry B Zorov
Intercellular cross-talk is a fundamental process for spreading cellular signals between neighbouring and distant cells to properly regulate their metabolism, to coordinate homeostasis, adaptation and survival as a functional tissue and organ. In this review, we take a close molecular view of the underpinning molecular mechanisms of such complex intercellular communications. There are several studied forms of cell-to-cell communications considered crucial for the maintenance of multicellular organisms. The most explored is paracrine signalling which is realised through the release of diffusible signalling factors (e...
January 23, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28185732/water-resources-management-in-the-urban-agglomeration-of-the-lake-biwa-region-japan-an-ecosystem-services-based-sustainability-assessment
#15
Xiaochen Chen, Yuqing Chen, Toshiyuki Shimizu, Jia Niu, Ken'ichi Nakagami, Xuepeng Qian, Baoju Jia, Jun Nakajima, Ji Han, Jianhua Li
An innovative ecosystem services-based sustainability assessment was conducted in the important urban agglomeration of the Lake Biwa region, Japan, covering the time period from 1950 to 2014. A 22-indicator system was established that was based on the major ecosystem services of Lake Biwa and its water courses, i.e., provisioning services regarding aquatic products and water; regulating services regarding floods and water quality; cultural services regarding recreation and tourism, scientific research, and environmental education; and supporting services regarding biodiversity...
February 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28176010/clinical-potentials-of-human-pluripotent-stem-cells
#16
REVIEW
Cristina Mora, Marialaura Serzanti, Antonella Consiglio, Maurizio Memo, Patrizia Dell'Era
Aging, injuries, and diseases can be considered as the result of malfunctioning or damaged cells. Regenerative medicine aims to restore tissue homeostasis by repairing or replacing cells, tissues, or damaged organs, by linking and combining different disciplines including engineering, technology, biology, and medicine. To pursue these goals, the discipline is taking advantage of pluripotent stem cells (PSCs), a peculiar type of cell possessing the ability to differentiate into every cell type of the body. Human PSCs can be isolated from the blastocysts and maintained in culture indefinitely, giving rise to the so-called embryonic stem cells (ESCs)...
February 8, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/28169910/long-term-outcome-of-microautologous-fat-transplantation-to-correct-temporal-depression
#17
Su-Shin Lee, Yu-Hao Huang, Tsung-Yin Lin, Chih-Kang Chou, Hidenobu Takahashi, Chung-Sheng Lai, Sin-Daw Lin, Tsai-Ming Lin
OBJECTIVE: Sunken temporal fossa appears oftentimes in Asians and resembles bad fortune that people wish to change. Numerous techniques and materials have been applied clinically for augmenting the sunken temporal fossa with variable results. The microautologous fat transplantation (MAFT) technique proposed by Lin et al in 2006 has demonstrated favorable results in facial rejuvenation. In the present study, the authors applied the MAFT technique with an innovative instrument in sunken temporal fossa and reported its results...
February 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28163911/rejuvenating-stem-cells-to-restore-muscle-regeneration-in-aging
#18
REVIEW
Eyal Bengal, Eusebio Perdiguero, Antonio L Serrano, Pura Muñoz-Cánoves
Adult muscle stem cells, originally called satellite cells, are essential for muscle repair and regeneration throughout life. Besides a gradual loss of mass and function, muscle aging is characterized by a decline in the repair capacity, which blunts muscle recovery after injury in elderly individuals. A major effort has been dedicated in recent years to deciphering the causes of satellite cell dysfunction in aging animals, with the ultimate goal of rejuvenating old satellite cells and improving muscle function in elderly people...
2017: F1000Research
https://www.readbyqxmd.com/read/28157498/rejuvenating-strategies-for-stem-cell-based-therapies-in-aging
#19
REVIEW
Joana Neves, Pedro Sousa-Victor, Heinrich Jasper
Recent advances in our understanding of tissue regeneration and the development of efficient approaches to induce and differentiate pluripotent stem cells for cell replacement therapies promise exciting avenues for treating degenerative age-related diseases. However, clinical studies and insights from model organisms have identified major roadblocks that normal aging processes impose on tissue regeneration. These new insights suggest that specific targeting of environmental niche components, including growth factors, ECM, and immune cells, and intrinsic stem cell properties that are affected by aging will be critical for the development of new strategies to improve stem cell function and optimize tissue repair processes...
February 2, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28154735/preventing-aging-with-stem-cell-rejuvenation-feasible-or-infeasible
#20
EDITORIAL
Kanya Honoki
Characterized by dysfunction of tissues, organs, organ systems and the whole organism, aging results from the reduced function of effective stem cell populations. Recent advances in aging research have demonstrated that old tissue stem cells can be rejuvenated for the purpose of maintaining the old-organ function by youthful re-calibration of the environment where stem cells reside. Biochemical cues regulating tissue stem cell function include molecular signaling pathways that interact between stem cells themselves and their niches...
January 26, 2017: World Journal of Stem Cells
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