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Rejuvenation

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https://www.readbyqxmd.com/read/28938532/modulation-of-gdf11-expression-and-synaptic-plasticity-by-age-and-training
#1
Emanuela De Domenico, Giovanna D'Arcangelo, Isabella Faraoni, Mattia Palmieri, Virginia Tancredi, Grazia Graziani, Paola Grimaldi, Lucio Tentori
The Growth Differentiation Factor 11 (GDF11) has been controversially involved in the aging/rejuvenation process. To clarify whether GDF11 is differently expressed during aging, we have evaluated GDF11 levels in skeletal muscles and hippocampi of young and old mice, sedentary or subjected to a 12-weeks triweekly training protocol. The results of real-time PCR and Western blot analyses indicate that skeletal muscles of sedentary old mice express higher levels of GDF11 compared to young animals (p < 0.05)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28935476/-botulinum-toxin-an-important-complement-for-facial-rejuvenation-surgery
#2
C Le Louarn
The improved understanding of the functional anatomy of the face and of the action of the botulinum toxin A leads us to determine a new injection procedure which consequently decreases the risk of eyebrow and eyelid ptosis and increases the toxin's injection possibilities and efficiencies. With less units of toxin, the technique herein described proposes to be more efficient on more muscles: variable toxin injections concentration adapted to each injected muscle are used. Thanks to a new procedure in the upper face, toxin A injection can be quite close to an endoscopic surgical action...
September 18, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28928652/indomethacin-increases-neurogenesis-across-age-groups-and-improves-delayed-probe-trial-difference-scores-in-middle-aged-rats
#3
James A McGuiness, Rachel B Scheinert, Aditya Asokan, Vivien-Charlott Stadler, Christian S Lee, Asha Rani, Ashok Kumar, Thomas C Foster, Brandi K Ormerod
We tested whether indomethacin or rosiglitazone treatment could rejuvenate spatial ability and hippocampal neurogenesis in aging rats. Young (4 mo; n = 30), middle-aged (12 mo; n = 31), and aged (18 mo; n = 31) male Fischer 344 rats were trained and then tested in a rapid acquisition water maze task and then fed vehicle (500 μl strawberry milk), indomethacin (2.0 mg/ml), or rosiglitazone (8.0 mg/ml) twice daily for the remainder of the experiment. A week after drug treatment commenced, the rats were given 3 daily BrdU (50 mg/kg) injections to test whether age-related declines in neurogenesis were reversed...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28927806/-aging-prevention-new-surgical-techniques-and-future-options-for-facial-rejuvenation
#4
C Le Louarn
Prevention of aging is mainly obtained through appropriate health practices, modulated by the genetic causes of aging. Causes of facial structural aging include gravity, volume loss, contraction of the mimic muscles and obviously biological aging of tissues. Among the very numerous new surgical technique of facial rejuvenation, we could point out: for the frontal region, obviously we are focus on the endoscopic and non-endoscopic frontal lifts. But also, we should note the transcutaneous Brow Shaping which with a well defined, step by step technique is indeed a simple way to improve a possible difficult situation; concerning the mid-face lift, as the main risk is the secondary eyelid malposition, a high Smas or a temporo-malar lift can be performed...
September 15, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28920924/impaired-angiopoietin-tie2-signaling-compromises-schlemm-s-canal-integrity-and-induces-glaucoma
#5
Jaeryung Kim, Dae-Young Park, Hosung Bae, Do Young Park, Dongkyu Kim, Choong-Kun Lee, Sukhyun Song, Tae-Young Chung, Dong Hui Lim, Yoshiaki Kubota, Young-Kwon Hong, Yulong He, Hellmut G Augustin, Guillermo Oliver, Gou Young Koh
Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemm's canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood...
September 18, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28919421/exosomes-derived-from-human-umbilical-cord-blood-mesenchymal-stem-cells-stimulates-rejuvenation-of-human-skin
#6
Yoon-Jin Kim, Sae Mi Yoo, Hwan Hee Park, Hye Jin Lim, Yu-Lee Kim, Seunghee Lee, Kyung-Sun Kang, Kwang-Won Seo
Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and permeation. We found that USC-CM has various growth factors associated with skin rejuvenation. Our in vitro results showed that USC-CM Exos integrate in Human Dermal Fibroblasts (HDFs) and consequently promote cell migration and collagen synthesis of HDFs...
September 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28918340/-cervical-lift-an-update
#7
D Labbé, P Guerreschi
The neck is an aesthetic unit for which a rejuvenation request is sometimes very targeted or ore often encompassed in a global surgical project of face-lift. To obtain a long lasting outcome, the plastic surgeon has to make a full, detailed, and exhaustive analysis of the neck in order to choose the best indication within the multiple surgical tools. A full clinical examination is the key point, every aspects are outlined. The numerous surgical choices are described, illustrated, and sometimes revisited in the light of targeted anatomical studies...
September 13, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28915290/lifting-the-lower-face-with-an-absorbable-polydioxanone-pdo-thread
#8
Kian Karimi, Alexandra Reivitis
Traditional rejuvenation techniques include chemical peels, rhytidectomy of the skin, laser resurfacing, injection of dermal fillers and neurotoxins, and invasive surgical procedures. Patients with brow ptosis, jowl formation, and deepening nasolabial folds currently seek antiaging procedures with no incisions and minimal downtime such as thread-lifting with barbed sutures. The present report describes a case in which polydioxanone threads were used to lift the lower third of a patient's face. Fillers were used to supplement the results achieved by the thread lift because often, when tissue has been lifted, volume deficits are revealed, which can be corrected with dermal fillers...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28913505/periorbital-facial-rejuvenation-applied-anatomy-and-pre-operative-assessment
#9
REVIEW
Mohsen Bahmani Kashkouli, Parya Abdolalizadeh, Navid Abolfathzadeh, Hamed Sianati, Maria Sharepour, Yasaman Hadi
PURPOSE: Since different subspecialties are currently performing a variety of upper facial rejuvenation procedures, and the level of knowledge on the ocular and periocular anatomy and physiology is different, this review aims to highlight the most important preoperative examinations and tests with special attention to the eye and periocular adnexal structures for general ophthalmologist and specialties other than oculo-facial surgeons in order to inform them about the fine and important points that should be considered before surgery to have both cosmetic and functional improvement...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28911889/-benefits-of-volumetric-to-facial-rejuvenation-part-2-dermal-fillers
#10
P Bui, A Pons Guiraud, C Lepage
Injectable substances known as fillers are used to palliate age-related atrophy and ptosis, and for their so-called "pseudo-lifting" action. They do not replace face and neck lift, but allow it to be postponed or, when injected after surgical lifting, make the result durable. Hyaluronic acid has a predominant and unchallenged place among fillers, well ahead of poly-L-lactic acid or calcium hydroxyapatite. Approaches and injection methods are the same for all fillers, corresponding to those for autologous fat injection, the reference substance, with a few particularities...
September 11, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28904422/melioration-in-anti-staphylococcal-activity-of-conventional-antibiotic-s-by-organic-acids-present-in-the-cell-free-supernatant-of-lactobacillus-paraplantarum
#11
Lavanya Rishi, Garima Mittal, Rajeev Kumar Agarwal, Taruna Sharma
In view of emerging drug resistance in pathogens, there is a need to explore alternative strategies to combat infections. Use of probiotics is one such option. In this regard, efficacy of Lactobacillus plantarum has been reported against Staphylococcus aureus. Here, we propose that cell free supernatant (CFS) of Lactobacillus paraplantarum when used in combination with conventional antibiotics viz. ampicillin and oxacillin [to which the methicillin resistant Staphylococcus aureus (MRSA) strains were originally resistant] reduce the minimum inhibitory concentrations of these antibiotics, rendering the combination either synergistic or additive against the tested MRSA strain...
September 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28903069/cell-reprogramming-therapeutic-potential-and-the-promise-of-rejuvenation-for-the-aging-brain
#12
REVIEW
Micaela López-León, Tiago F Outeiro, Rodolfo G Goya
Aging is associated with a progressive increase in the incidence of neurodegenerative diseases, with Alzheimer's (AD) and Parkinson's (PD) disease being the most conspicuous examples. Within this context, the absence of efficacious therapies for most age-related brain pathologies has increased the interest in regenerative medicine. In particular, cell reprogramming technologies have ushered in the era of personalized therapies that not only show a significant potential for the treatment of neurodegenerative diseases but also promise to make biological rejuvenation feasible...
September 10, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28902026/chemical-peels-indications-and-special-considerations-for-the-male-patient
#13
Jeave Reserva, Amanda Champlain, Seaver L Soon, Rebecca Tung
BACKGROUND: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men. OBJECTIVE: To review the indications for chemical peels with an emphasis on performing this procedure in male patients. MATERIALS AND METHODS: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28902023/novel-modality-for-neck-rejuvenation-a-prospective-multicenter-trial-of-percutaneous-radiofrequency-ablation-of-the-cervical-branch-of-the-facial-nerve
#14
Daniel Rivlin, D Ryan Skinner, Christina Y Steinmetz-Rodriguez, Jordan S Fabrikant, Marie A Stoddard, Jeffrey J So, Shauntell J Solomon, Ronald L Moy
BACKGROUND: Neck rejuvenation offers few modalities of treatments limited to either invasive plastic surgery or temporary neuromodulation using botulinum toxin. OBJECTIVE: To access the efficacy, longevity, and safety of percutaneous monopolar radiofrequency (RF) ablation of the cervical branch of the facial nerve innervating the platysma for neck rejuvenation. MATERIALS AND METHODS: This prospective, multicenter trial enrolled 19 adult patients with noticeable platysmal banding at 2 different centers...
September 8, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28901439/long-noncoding-rna%C3%A2-p21-modulates-cellular-senescence-via-the-wnt-%C3%AE-%C3%A2-catenin-signaling-pathway-in-mesenchymal-stem-cells
#15
Wenzheng Xia, Lei Zhuang, Xia Deng, Meng Hou
Mesenchymal stem cell (MSC)‑based therapies have demonstrated efficacy in animal models of cardiovascular diseases. However, MSCs decrease in quantity and quality with age, which reduces their capacity for damage repair. Long noncoding (lnc) RNAs regulate gene transcription and the fate of post‑transcriptional mRNA, affecting a broad range of age‑associated physiological and pathological conditions, including cardiovascular disease and cancer cell senescence. However, the functional role of lncRNAs in stem cell senescence remains largely unknown...
September 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28898244/neuroplace-categorizing-urban-places-according-to-mental-states
#16
Lulwah Al-Barrak, Eiman Kanjo, Eman M G Younis
Urban spaces have a great impact on how people's emotion and behaviour. There are number of factors that impact our brain responses to a space. This paper presents a novel urban place recommendation approach, that is based on modelling in-situ EEG data. The research investigations leverages on newly affordable Electroencephalogram (EEG) headsets, which has the capability to sense mental states such as meditation and attention levels. These emerging devices have been utilized in understanding how human brains are affected by the surrounding built environments and natural spaces...
2017: PloS One
https://www.readbyqxmd.com/read/28894392/fractional-co2-laser-treatment-for-vulvovaginal-atrophy-symptoms-and-vaginal-rejuvenation-in-perimenopausal-women
#17
César Arroyo
BACKGROUND: This study investigated a novel fractional carbon dioxide (CO2) laser for treatment of symptoms associated with vulvovaginal atrophy (VVA) in perimenopausal women. METHODS: The study included 21 perimenopausal women (mean age 45±7 years) treated three times by CO2 laser resurfacing and coagulation of the vaginal canal tissue and mucosal tissue of the introitus. Vaginal health index (VHI) scores were computed by the investigator at baseline and follow-ups...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28891757/ending-aging-the-rejuvenation-breakthroughs-that-could-reverse-human-aging-in-our-lifetime
#18
Miles Matise
No abstract text is available yet for this article.
September 11, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28889220/rapamycin-treatment-attenuates-age-associated-periodontitis-in-mice
#19
Jonathan Y An, Ellen K Quarles, Surapat Mekvanich, Alex Kang, Anthony Liu, Danielle Santos, Richard A Miller, Peter S Rabinovitch, Timothy C Cox, Matt Kaeberlein
Interventions that target biological mechanisms of aging have great potential to enhance quality of life by delaying morbidity and mortality. The FDA-approved drug rapamycin is a compelling candidate for such an intervention. In a previous study, it was reported that 3 months of rapamycin treatment is sufficient to increase life expectancy and remodel the gut microbiome in aged mice. Transient treatment with rapamycin or a rapamycin derivative has also been shown to delay immune stem cell senescence and rejuvenate immune function in aged mice and elderly people...
September 9, 2017: GeroScience
https://www.readbyqxmd.com/read/28887865/plasma-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#20
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
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