keyword
https://read.qxmd.com/read/38525491/first-phase-development-of-a-patient-reported-outcome-measure-for-midface-oncology
#1
JOURNAL ARTICLE
Amanda E Yung, Jason Luong, Gareth Crouch, Angela M Hong, Arjuna Ananda, Simon Taylor, Ilias Kotronakis, Tsu-Hui Hubert Low, Michael S Elliott, Kate McBride, Claudia Rutherford, Jonathan R Clark, Sydney Ch'ng
BACKGROUND: Facial cancer surgery involving the midface (comprising the lower eyelids, nose, cheeks, and upper lip) can have debilitating life-changing functional, social, and psychological impacts on the patient. Midface symptoms are inadequately captured by existing patient-reported outcome measures (PROMs). PROMs are increasingly used for individual patient care, quality improvement, and standardized reporting of treatment outcomes. This study aimed to present our findings from the first phase of the development of a midface, specifically periocular and nasal, PROM...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38517430/primary-cilium-in-neural-crest-cells-crucial-for-anterior-segment-development-and-corneal-avascularity
#2
JOURNAL ARTICLE
Seungwoon Seo, Seong Keun Sonn, Hyae Yon Kweon, Jing Jin, Tsutomu Kume, Je Yeong Ko, Jong Hoon Park, Goo Taeg Oh
PURPOSE: Intraflagellar transport 46 (IFT46) is an integral subunit of the IFT-B complex, playing a key role in the assembly and maintenance of primary cilia responsible for transducing signaling pathways. Despite its predominant expression in the basal body of cilia, the precise role of Ift46 in ocular development remains undetermined. This study aimed to elucidate the impact of neural crest (NC)-specific deletion of Ift46 on ocular development. METHODS: NC-specific conditional knockout mice for Ift46 (NC-Ift46F/F) were generated by crossing Ift46F mice with Wnt1-Cre2 mice, enabling the specific deletion of Ift46 in NC-derived cells (NCCs)...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38514912/a-novel-hybrid-bont-a-and-hyaluronic-acid-cannula-based-technique-for-eyelid-ptosis-and-periorbital-rejuvenation
#3
JOURNAL ARTICLE
Luis Alberto Parra Hernández, Andrea Marcela Parra Hernández, Desiree Castelanich, Daniella Shitara, Maricarmen Chacín
BACKGROUND: Eyelid ptosis is characterized by an inferior displacement of the upper eyelid when the eye assumes its primary position. Besides its aesthetic implications, ptosis can also adversely affect visual acuity. OBJECTIVE: This study aimed to evaluate the simultaneous administration of IncobotulinumtoxinA (IncoBonTA) and hyaluronic acid effect in eyelid ptosis and ocular rejuvenation. METHODS: A novel, non-surgical technique for eyelid ptosis management involving IncoBonTA and hyaluronic acid the co-administration within a single syringe, and applied using a cannula...
March 21, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38504670/severe-hyperglycemia-with-teprotumumab-for-treatment-of-thyroid-eye-disease
#4
Savannah Cottom, Brayden Barrientez, Andrew Melson
INTRODUCTION: Thyroid eye disease (TED) is a rare condition involving autoimmune-mediated inflammation of the orbit and periocular structures, which can result in many debilitating symptoms. Teprotumumab, a monoclonal antibody that targets the insulin-like growth factor 1 receptor, is gaining popularity for the treatment of TED. In fact, owing to its efficacy and side effect profile, some recommend that it be considered as a first-line therapy for patients with TED. While teprotumumab is often chosen due to its efficacy and relatively favorable side effect profile compared to other treatments, there is a known risk of hyperglycemia with this mechanism of action, which is well described through clinical trials in the oncology literature...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38504269/clinicopathological-study-of-ophthalmic-cutaneous-and-mucocutaneous-non-langerhans-cell-histiocytic-lesions
#5
JOURNAL ARTICLE
Hind Manaa Alkatan, Dalal R Fatani, Azza M Y Maktabi, Tariq A Alzahem
BACKGROUND: The "C group" of the histiocytic disorders is characterized by non-Langerhans-cell histiocytic lesions in the skin, mucosal surfaces, or both, out of which Juvenile xanthogranuloma (JXG) is the most common typically affecting the skin. The eye is the most common extra-cutaneous site of JXG., we aim at providing our clinical and histopathological experience with this group of diseases including the adult-onset xanthogranuloma (AXG). METHODS: This is a retrospective cohort study of all patients with the tissue diagnosis of ocular and periocular cutaneous and mucocutaneous non-LCH disorders who presented to us over a period of 25 years (January 1993 to December 2018)...
March 19, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38500654/review-of-recent-advances-in-managing-periocular-skin-malignancies
#6
REVIEW
Daniel C Trotier, Leslie Huang, Suzanne W van Landingham, Adam R Burr, Vincent T Ma
Management of cutaneous malignancies can be particularly challenging when they are located in the periocular region. The standard of care for localized disease is complete surgical excision, but this may not be possible without significant disruption to visual structures and facial appearance. Definitive radiation may be an option for some patients who cannot or do not wish to undergo surgery. Advances in systemic treatment options for locally advanced and metastatic skin cancers in the past 10 years have prompted investigation into neoadjuvant treatment of periocular cancers...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38500429/-clinical-diagnosis-and-treatment-of-14-cases-of-scar-cancer-ulcer-wound-on-head-and-face
#7
JOURNAL ARTICLE
Xinchong Chen, Guangtao Huang
OBJECTIVE: To analyze the clinical characteristics of scar cancer ulcer wound of head and face, and to investigate its diagnosis and treatment. METHODS: The clinical data of 14 patients with head and facial scar cancer ulcer wounds who met the selection criteria and admitted between January 2021 and March 2022 were retrospectively analyzed. There were 8 males and 6 females. The age of onset ranged from 21 to 81 years with an average age of 61.6 years. The incubation period ranged from 1 month to 70 years, with a median of 4 years...
March 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/38494639/a-case-of-periocular-pyoderma-gangrenosum-successfully-managed-with-the-aid-of-hyperbaric-oxygen-therapy
#8
JOURNAL ARTICLE
Julian Pearce, Yasir Al-Wahab, Archana Rao, Janakan Natkunarajah
No abstract text is available yet for this article.
March 18, 2024: Clinical and Experimental Dermatology
https://read.qxmd.com/read/38481484/patterns-of-concomitant-traumatic-brain-injury-and-ocular-trauma-in-us-service-members
#9
JOURNAL ARTICLE
Weidong Gu, Lucas L Groves, Scott F McClellan
BACKGROUND: Concomitant traumatic brain injury (TBI) and ocular trauma (OT) are caused by the same physical mechanisms, which may complicate therapeutic intervention if screening and evaluation of each condition are not promptly initiated. The aim of this study is to identify concomitant TBI in OT patients and characterize the pattern of those injured service members (SMs) in non-combat environments to assist in the early detection and treatment of both TBI and OT. METHODS: Encounters matching the case definitions of TBI and OT for injured SMs were extracted from the Military Health System...
2024: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/38465363/outcomes-of-eyes-lost-to-follow-up-after-treatment-with-intraocular-or-periocular-steroid-injections
#10
JOURNAL ARTICLE
Raziyeh Mahmoudzadeh, Mirataollah Salabati, Rachel Israilevich, John W Hinkle, Anthony Obeid, M Ali Khan, Jason Hsu, Varun Chaudhary, Sunir J Garg
Purpose: To evaluate the visual, intraocular pressure (IOP), and anatomic outcomes of eyes with loss to follow-up (LTFU) after intravitreal or periocular steroid injections. Methods: Patients receiving intraocular or periocular steroid injections and with LTFU for at least 180 days were included in this retrospective cohort study. Charts were reviewed for the visual acuity (VA), IOP, and central foveal thickness at the visit before LTFU, the first return visit, and 3, 6, and 12 months after return. Results: Fifty-three eyes of 47 patients were identified...
2024: Journal of Vitreoretinal Diseases
https://read.qxmd.com/read/38456099/advanced-periocular-basal-cell-carcinoma-with-orbital-invasion-update-on-management-and-treatment-advances
#11
JOURNAL ARTICLE
Alvaro Bengoa-González, Enrique Mencía-Gutiérrez, María Garrido, Elena Salvador, María-Dolores Lago-Llinás
PURPOSE: Basal cell carcinoma (BCC) is the most frequent malignant periocular tumor. It is associated with exposure to ultraviolet radiation, and its incidence is gradually increasing. It may occasionally display more aggressive behavior and result in orbital or intracranial invasion. Mortality from periocular BBC with orbital invasion is very low, but the associated morbidity can be significant, from disfigurement to blindness. Traditionally, these cases have been treated with orbital exenteration or with radiotherapy (RT), but in recent years, hedgehog pathway inhibitors (HPIs) have emerged, are effective in more serious cases, and are used primarily or combined with surgery, changing our perspective on the management of these patients...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38455097/unlocking-the-versatile-potential-adipose-derived-mesenchymal-stem-cells-in-ocular-surface-reconstruction-and-oculoplastics
#12
REVIEW
Pier Luigi Surico, Anna Scarabosio, Giovanni Miotti, Martina Grando, Carlo Salati, Pier Camillo Parodi, Leopoldo Spadea, Marco Zeppieri
This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enhancement, demands advanced solutions for tissue restoration, functional and aesthetic refinement, and aging. Investigating immunomodulatory, regenerative, and healing capacities of MSCs, this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside, addressing common unmet needs in the field of reconstructive and regenerative surgery...
February 26, 2024: World Journal of Stem Cells
https://read.qxmd.com/read/38437813/severe-recurrence-and-retinal-inflammatory-infiltration-after-cessation-of-immunosuppression-for-multifocal-choroiditis-and-panuveitis
#13
JOURNAL ARTICLE
Jeannette Ossewaarde-van Norel, Richard F Spaide
PURPOSE: To describe a severe recurrence of intraocular inflammation following the cessation of immunosuppression, previously administered for multifocal choroiditis and panuveitis (MCP). METHODS: Retrospective chart review. RESULTS: A 27-year-old woman with MCP initially was treated with intravenous and oral corticosteroids and photodynamic therapy because of an active macular neovascularization in both eyes. Mycophenolate was soon started and the recurrences during tapering of the oral corticosteroids in the first months were treated with periocular corticosteroids and anti-vascular endothelial growth factor injections as they became available...
March 4, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38425639/xeroderma-pigmentosum-with-ocular-surface-squamous-neoplasia-a-case-report
#14
Sravanthi Malikireddy
Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder characterized by defective DNA repair. Patients with this disorder are at increased risk of developing various oculocutaneous malignancies. We report a rare case of a child with XP with bilateral ocular surface squamous neoplasia (OSSN) and left eye (OS) medial canthal basal cell carcinoma (BCC)...
January 2024: Curēus
https://read.qxmd.com/read/38395223/allergic-contact-dermatitis-to-topical-ophthalmic-drugs-review-of-frequently-used-allergens-in-spain
#15
REVIEW
M D Pegalajar-García, B A Coronel-González, F J Navarro-Triviño
Allergic contact dermatitis induced by the use of ophthalmic topical drugs is one of the most common causes of eyelid dermatitis. The introduction of new formulations, both of active ingredients and excipients, and the lack of marketing in some of them, makes patch testing in patients whose source of contact are topical ophthalmic drugs truly challenging. Across this manuscript, most, if not all, topical ophthalmic drugs used in our national health system have been collected, including information on the allergens available, and the concentration and vehicle advised for those that still remain unavailable...
February 21, 2024: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/38391357/endocrine-mucin-producing-sweat-gland-carcinoma-of-the-eyelid-a-diagnostic-challenge
#16
JOURNAL ARTICLE
Viral M Bhanvadia, Ravija Kathiara, Ami Shah, Wilhemina Asari
Skin adnexal or sweat gland neoplasms are rare adnexal tumors that pose a diagnostic challenge for both ophthalmologists and pathologists. Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is an uncommon low grade carcinoma of eccrine ducts with a predilection to occur in the periocular region in the elderly female. We present a rare case of 65-year-old healthy male who presented with a lobulated mass in the left eye lower lid, clinically suspected as sebaceous gland carcinoma, diagnosed as endocrine mucin-producing sweat gland carcinoma histopathologically...
July 6, 2023: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38388832/robotic-assisted-orbital-surgery-for-resection-of-advanced-periocular-tumours-a-case-series-report-on-the-feasibility-safety-and-outcome
#17
JOURNAL ARTICLE
Mohsan Malik, Claire Daniel, Jack Faulkner, Jimmy Uddin, Asit Arora, Jean-Pierre Jeannon
PURPOSE: Orbital surgery benefits from well-designed instrumentation that offers gentle tissue manipulation, high manoeuvrability and control. Nevertheless, in confined spaces, tissue manipulation must be accomplished with exceptionally high accuracy and precision. This is where robotic surgery offers an advantage. We aimed to evaluate a robotic-assisted surgical system's feasibility, safety and outcome in assisting tumour clearance. PATIENTS AND METHODS: A case series of patients with advanced periocular tumours undergoing robotic-assisted globe-sparing resection was performed using the DaVinci XI system (Intuitive Surgical, Inc)...
February 22, 2024: Eye
https://read.qxmd.com/read/38381740/intralesional-interferon-alpha-2b-as-a-novel-treatment-for-periocular-squamous-cell-carcinoma-in-horses
#18
JOURNAL ARTICLE
Brittany B Martabano, Steven Dow, Lyndah Chow, Margaret M V Williams, Maura K Mack, Rebecca Bellone, Kathryn L Wotman
OBJECTIVE: To determine the safety and efficacy of perilesional human recombinant interferon alpha-2b (IFNα2b) for treatment of periocular squamous cell carcinoma (PSCC) in horses. ANIMALS STUDIED: Eleven horses (12 eyes) with PSCC were enrolled in this prospective clinical study with owner consent. PROCEDURES: Systemically healthy horses were included in the study following confirmation of PSCC via biopsy. Every two weeks for a maximum of six treatments, horses were sedated and perilesional injection of IFNα2b (10 million IU) was performed...
2024: PloS One
https://read.qxmd.com/read/38381616/anti-inflammatory-medication-use-after-cataract-surgery-online-survey-of-practice-patterns
#19
JOURNAL ARTICLE
Abdelhalim A Awidi, David F Chang, Kamran M Riaz, Ximin Li, Scott LaBorwit, Nazlee Zebardast, Divya Srikumaran, Christina R Prescott, Yassine J Daoud, Fasika A Woreta
PURPOSE: To determine current prescribing patterns for topical or intraocular/periocular anti-inflammatory medications (AIMs) after routine cataract surgery. SETTING: kera-net online members. DESIGN: Cross-sectional survey. METHODS: An online survey was distributed to subscribers of kera-net, a global online platform sponsored by the Cornea Society. Questions were asked regarding the use of topical or intraocular/periocular AIM after cataract surgery and types of medications prescribed...
March 1, 2024: Journal of Cataract and Refractive Surgery
https://read.qxmd.com/read/38376797/risk-factors-for-ocular-surface-irritation-symptoms-in-inactive-mild-and-moderate-to-severe-graves-orbitopathy
#20
JOURNAL ARTICLE
Yun Yu, Yu-Xin Hu, Ming-Xi Lu, Zheng-Long Ouyang, Ming-Tong Xu, Li-Yan Zhao, Mei Wang
INTRODUCTION: This study aims to analyze risk factors for ocular surface irritation symptoms in patients with non-corneal-damage inactive mild and moderate-to-severe Graves' orbitopathy (GO). METHODS: This retrospective study enrolled 307 patients with non-corneal-damage inactive GO admitted to Sun Yat-sen Memorial Hospital from April 2017 to September 2023. The activity and severity of GO were evaluated using the Clinical Activity Score (CAS) and the European Group on Graves' Orbitopathy (EUGOGO) classification, respectively...
February 20, 2024: Ophthalmology and Therapy
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