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Graves' orbitopathy

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https://www.readbyqxmd.com/read/29772544/antigen-specific-therapy-of-graves%C3%A2-disease-and-orbitopathy-by-induction-of-tolerance
#1
Martin Ungerer, Julia Fabbender, Hans-Peter Holthoff
Graves´ disease is an autoimmune disorder, which is characterized by stimulatory antibodies targeting the human thyrotropin receptor (TSHR), resulting in hyperthyroidism and multiple organ damage. The disease can be modelled in mice using adenoviral immunizations with the extracellular A subunit of the TSHR, which induces a long-term stable disease state. TSHR binding cAMP-stimulatory antibodies, thyroid enlargement, elevated serum thyroxin levels, tachycardia, cardiac hypertrophy and orbitopathy are observed in these Ad-TSHR-immunized mice...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29772543/functional-diagnostics-for-thyrotropin-hormone-receptor-autoantibodies-bioassays-prevail-over-binding-assays
#2
Simon David Lytton, Anke Schluter, Paul J Banga
Autoantibodies to the thyrotropin hormone receptor (TSH-R) are directly responsible for the hyperthyroidism in Graves' disease and mediate orbital manifestations in Graves' orbitopathy (otherwise known as thyroid eye disease). These autoantibodies are heterogeneous in their function and collectively referred to as TRAbs. Measurement of TRAbs is clinically important for diagnosis of a variety of conditions and different commercial assays with high sensitivity and specificity are available for diagnostic purposes...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29768627/tsh-receptor-antibodies-may-prevent-bone-loss-in-pre-and-postmenopausal-women-with-graves-disease-and-graves-orbitopathy
#3
Mira Siderova, Kiril Hristozov, Aleksandra Tsukeva
OBJECTIVE: Thyrotoxicosis is established risk factor for osteoporosis due to increased bone turnover. Glucocorticoids often administered for Graves' orbitopathy (GO) have additional negative effect on bone mineral density (BMD). Our aim was to examine the influence of thyroid hormones, TSH, TSH-receptor antibodies (TRAb) and glucocorticoid treatment on bone in women with Graves' thyrotoxicosis and Graves' orbitopathy (GO). SUBJECTS AND METHODS: Forty seven women with Graves' disease, mean age 55...
March 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29744075/graves-orbitopathy-after-allogeneic-bone-marrow-transplantation-in-a-patient-with-fanconi-anemia-side-effect-of-alemtuzumab-therapy
#4
Luminita Nicoleta Cima, Ioana Maria Lambrescu, Lavinia Stejereanu, Anca Colita, Reuven Or, Simona Fica
A few cases of thyroid eye disease following alemtuzumab therapy have been described in patients with multiple sclerosis. Our patient is the first case of Graves' orbitopathy after alemtuzumab conditioning for hematopoietic stem cell transplantation.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29736194/thyroid-associated-orbitopathy-and-biomarkers-where-we-are-and-what-we-can-hope-for-the-future
#5
REVIEW
Natacha Turck, Simone Eperon, Maria De Los Angeles Gracia, Aurélie Obéric, Mehrad Hamédani
Background: Thyroid-associated orbitopathy (TAO) is the most common autoimmune disease of the orbit. It occurs more often in patients presenting with hyperthyroidism, characteristic of Graves' disease, but may be associated with hypothyroidism or euthyroidism. The diagnosis of TAO is based on clinical orbital features, radiological criteria, and the potential association with thyroid disease. To date, there is no specific marker of the orbital disease, making the early diagnosis difficult, especially if the orbital involvement precedes the thyroid dysfunction...
2018: Disease Markers
https://www.readbyqxmd.com/read/29729448/quality-of-life-and-neuropsychiatric-disorders-in-patients-with-graves-orbitopathy-current-concepts
#6
REVIEW
Alice Bruscolini, Marta Sacchetti, Maurizio La Cava, Marcella Nebbioso, Angela Iannitelli, Adele Quartini, Alessandro Lambiase, Massimo Ralli, Armando de Virgilio, Antonio Greco
Graves' disease (GD) is an autoimmune chronic thyroiditis frequently associated with development of Graves' orbitopathy (GO) characterized by proptosis, strabismus, impairment of visual function, ocular surface inflammation and dry eye. As consequence, patients with GO experience impairment of quality of life and social function and could develop a neurobehavioral syndrome, ranging from anxious to depressive or psychotic disorders. To date, the pathogenic mechanism underlying neuropsychiatric disorders in patients with GD has not been clearly understood...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29721541/cutting-edge-endonasal-surgical-approaches-to-thyroid-ophthalmopathy
#7
REVIEW
Matthew A Tyler, Caroline C Zhang, Alok T Saini, William C Yao
Objective: Thyroid orbitopathy is a poorly understood extrathyroidal manifestation of Graves' disease that can cause disfiguring proptosis and vision loss. Orbital decompression surgery for Graves' orbitopathy (GO) can address both cosmetic and visual sequelae of this autoimmune condition. Endonasal endoscopic orbital decompression provides unmatched visualization and access to inferomedial orbital wall and orbital apex. This review examines the state of the art approaches employed in endonasal endoscopic orbital decompression for GO...
April 2018: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29710176/lymphocyte-expression-in-graves-orbitopathy
#8
Suzanne K Freitag, N Grace Lee
No abstract text is available yet for this article.
April 19, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29710102/association-of-t-and-b-cells-infiltrating-orbital-tissues-with-clinical-features-of-graves-orbitopathy
#9
Giovanna Rotondo Dottore, Liborio Torregrossa, Patrizio Caturegli, Ilaria Ionni, Angela Sframeli, Elena Sabini, Francesca Menconi, Paolo Piaggi, Stefano Sellari-Franceschini, Marco Nardi, Francesco Latrofa, Paolo Vitti, Claudio Marcocci, Fulvio Basolo, Michele Marinò
Importance: Graves orbitopathy (GO) responds to immunosuppressive treatments when clinically active but poorly when inactive. In other autoimmune diseases, response has been ascribed to a reduction in lymphocytes infiltrating the target organ. It is not known whether active vs inactive GO differs in this regard, which would help in understanding the link between GO immunologic features and clinical behavior. Objective: To investigate the association between orbital lymphocytic infiltrate and GO clinical features...
April 19, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29670918/management-of-patients-with-graves-disease-and-orbital-involvement-role-of-spectral-domain-optical-coherence-tomography
#10
Alice Bruscolini, Maurizio La Cava, Magda Gharbiya, Marta Sacchetti, Lucia Restivo, Chiara Nardella, Marco Marenco, Alessandro Lambiase
Purpose: To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves' disease and orbitopathy (GO). Methods: Thirty-six eyes of 18 patients with GO and 36 eyes of 18 age-matched control subjects were included in this retrospective observational study. All the subjects underwent a complete ophthalmological evaluation, including clinical activity score (CAS) and exophthalmometry...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29663139/corneal-biopsy-for-diagnosis-of-recalcitrant-microbial-keratitis
#11
Dana Robaei, U-Teng Chan, Pauline Khoo, Svetlana Cherepanoff, Yi-Chiao Li, Jane Hanrahan, Stephanie Watson
PURPOSE: To document the findings of corneal biopsies for progressive microbial keratitis in a large tertiary referral institution. METHODS: A retrospective medical records review of all patients who underwent at least one corneal biopsy for the diagnosis of microbial keratitis at Sydney Eye Hospital, Australia between January 1, 2010 and December 31, 2016 was performed. RESULTS: Thirty-eight patients (18 men and 20 women) underwent a corneal biopsy for progressive microbial keratitis unresponsive to broad-spectrum topical antimicrobials...
April 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29652204/low-dose-rituximab-for-active-moderate-to-severe-graves-orbitopathy-resistant-to-conventional-treatment
#12
Laurence Du Pasquier-Fediaevsky, Stefan Andrei, Michel Berche, Laurence Leenhardt, Emmanuel Héron, Sébastien Rivière
PURPOSE: To report low-dose rituximab effect in Graves' orbitopathy (GO) resistant to conventional treatment. METHODS: Retrospective analysis of medical records, filled in according to the European Group on Graves' Orbitopathy (EUGOGO) standards, of patients with active moderate-to-severe GO who received low-dose rituximab after failure of conventional treatment. Efficacy was defined by a decrease of the clinical activity score of 2 points or <4/10. RESULTS: Among 219 patients treated between 2012 and 2016 by pulse methylprednisolone, possibly followed by oral steroids and/or orbital radiotherapy, 15 (6...
April 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29650691/predictive-score-for-the-development-or-progression-of-graves-orbitopathy-in-patients-with-newly-diagnosed-graves-hyperthyroidism
#13
Wilmar M Wiersinga, Miloš Žarković, Luigi Bartalena, Simone Donati, Petros Perros, Onyebuchi Okosieme, Daniel Morris, Nicole Fichter, Juerg Lareida, Georg von Arx, Chantal Daumerie, Maria-Cristina Burlacu, George J Kahaly, Susanne Pitz, Biljana Beleslin, Jasmina Ćirić, Goksun Ayvaz, Onur Konuk, Fusun Balos Toruner, Mario Salvi, Danila Covelli, Nicola Currò, Laszlo Hegedüs, Thomas Heiberg Brix
Objective: To construct a predictive score for the development or progression of Graves' orbitopathy (GO) in Graves' hyperthyroidism (GH). Design: Prospective observational study in patients with newly diagnosed GH, treated with antithyroid drugs (ATD) for 18 months at ten participating centers from EUGOGO in 8 European countries. Methods: 348 patients were included with untreated GH but without obvious GO. Mixeded effects logistic regression was used to determine best predictors. A predictive score (called PREDIGO) was constructed...
April 12, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29601105/efficacy-and-safety-of-rituximab-for-the-treatment-of-graves-orbitopathy-a-meta-analysis-of-randomized-controlled-trials
#14
Wan-Chen Shen, Chia-Hwa Lee, El-Wui Loh, An-Tsz Hsieh, Lawrence Chen, Ka-Wai Tam
STUDY OBJECTIVE: To investigate the efficacy and safety of rituximab in patients with Graves' orbitopathy (GO). DESIGN: Systematic review and meta-analysis of four randomized controlled trials. PATIENTS: A total of 293 patients with GO who received rituximab or control (either glucocorticoids, the established first-line therapy [three trials], or saline [one trial]). MEASUREMENTS AND RESULTS: Relevant studies published before February 2018 were identified from the PubMed, Embase, Cochrane Library, and Scopus databases, and the ClinicalTrials...
March 30, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29594060/prevalence-of-radiological-signs-of-dysthyroid-optic-neuropathy-in-magnetic-resonance-imaging-in-patients-with-active-moderate-to-severe-and-very-severe-graves-orbitopathy
#15
Beata Rutkowska-Hinc, Edyta Maj, Anna Jabłońska, Justyna Milczarek-Banach, Tomasz Bednarczuk, Piotr Miśkiewicz
Background: Differentiating between dysthyroid optic neuropathy (DON), which requires urgent therapy to prevent blindness, and moderate-to-severe Graves orbitopathy (GO) remains challenging. There is no pathognomonic feature of DON in either ophthalmological or radiological examinations. Objectives: Our aim was to investigate the prevalence of radiological signs of DON in magnetic resonance imaging (MRI) in patients with moderate-to-severe and very severe GO. Methods: Two researchers reassessed MRI scans of 23 consecutive patients (46 eyes) with active, moderate-to-severe GO and 14 patients (23 eyes) with very severe GO...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29594055/occurrence-of-graves-orbitopathy-and-graves-hyperthyroidism-after-a-trauma-to-the-eye
#16
Elena Sabini, Ilaria Ionni, Roberto Rocchi, Paolo Vitti, Claudio Marcocci, Michele Marinò
Background: Graves' orbitopathy (GO) is believed to be the consequence of autoimmunity against antigens that are present both in the thyroid and orbital tissues. Massive release of thyroid antigens causes the appearance or deterioration of GO in patients with Graves' hyperthyroidism (GH), as it occurs following radioiodine treatment. In theory, a similar release of autoantigens may occur at the eye level, for example due to an orbital trauma or surgical manipulation. To our knowledge, this is the first report of a case of de novo appearance of GO and then GH after an eye trauma, possibly reflecting spreading of autoantigens and activation of the immune system against shared orbital and thyroid antigens...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29593440/graves-disease-in-central-ghana-clinical-characteristics-and-associated-factors
#17
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Ishmael Kyei
Background: Graves disease (GD) has increased in prevalence over the past decade in Africa. Despite this, the condition is not well described, especially in sub-Saharan Africa. Objective: We have described the clinical characteristics and associated factors of GD in a cohort of patients attending a resource-limited setting tertiary hospital. Methods: Patients were examined thoroughly and systematically tested for the degree of clinical and biochemical thyroid status...
2018: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/29589999/biguanides-metformin-and-phenformin-generate-therapeutic-effects-via-amp-activated-protein-kinase-extracellular-regulated-kinase-pathways-in-an-in-vitro-model-of-graves-orbitopathy
#18
Ye Eon Han, Sena Hwang, Jin Hee Kim, Jung Woo Byun, Jin Sook Yoon, Eun Jig Lee
BACKGROUND: It was hypothesized that the biguanides metformin and phenformin, which are anti-hyperglycemic drugs used for diabetes mellitus, would have therapeutic effects in an in vitro model of Graves' orbitopathy (GO). Because adipogenesis, hyaluronan production, and inflammation are considered important in the pathogenesis of GO, this study aimed to determine the therapeutic effects and underlying mechanisms of biguanides on these parameters. METHODS: In vitro experiments were performed using primary cultured orbital fibroblasts from patients with GO...
April 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29559498/post-partum-and-non-post-partum-relapsing-graves-hyperthyroidism-display-different-response-to-anti-thyroid-drugs
#19
Mario Rotondi, Valentina Capelli, Francesca Coperchini, Sara Pinto, Laura Croce, Massimo Tonacchera, Luca Chiovato
DESIGN: Graves' disease (GD) patients in remission after a full course of methimazole (MMI) therapy are at risk for a relapse of hyperthyroidism during the post-partum (PP) period, but whether this relapse may display any peculiarity is still unknown. Aim of this study was to compare GD patients undergoing a relapse of hyperthyroidism either in the PP period or not. METHODS: We retrospectively evaluated fourty-three GD female patients in their childbearing age who experienced a relapse of hyperthyroidism...
March 20, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29557835/prevalence-of-ocular-hypertension-and-glaucoma-as-well-as-associated-factors-in-graves-orbitopathy
#20
Ji Won Kim, JaeSang Ko, Young Jun Woo, Hyoung Won Bae, Jin Sook Yoon
PURPOSE: To determine the prevalence of ocular hypertension (OHT) and open-angle glaucoma (OAG) in patients with GO and to investigate the associations between clinical features of the disease and the prevalence of OHT and OAG. METHODS: A cross-sectional analytic study was conducted among a total of 1128 patients with Graves' orbitopathy (GO). A complete ophthalmic examination was performed, including intraocular pressure, optic disc photography, visual field testing using a Humphrey visual field analyzer, and retinal nerve fiber layer thickness measured by optical coherence tomography...
March 19, 2018: Journal of Glaucoma
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