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folic acid and cancer

Zhili Deng, Menghuan Tang, Li Zhao, Yijuan Long, Zuhuang Wen, Yuan Cheng, Huzhi Zheng
A novel targeting drug delivery system for cancer therapy based on H(+)-triggered bubble-generating nanosystems (BGNSs) was engineered. First, hollow mesoporous silica nanoparticles (HMSNs) were used to load doxorubicin (DOX). Then, the obtained drug-loaded HMSNs were treated with NaHCO3 to prepare the BGNSs. The BGNSs were coated with polydopamine (pDA), and finally, folic acids (FA) were anchored on the nanosystems to obtain the desired nanoscale drug delivery system (BGNSs@pDA-FA). BGNSs@pDA-FA was effectively internalized by cancer cells through folate receptor-mediated endocytosis and generated CO2 bubbles under the acidic environment of the lysosomes, thus enhancing lysosomal membrane permeability (LMP) to release caspase-3 into the cytoplasm, resulting in cancer cell death via an apoptosis-like pathway...
September 14, 2017: Colloids and Surfaces. B, Biointerfaces
Yuanqing Wei, Zhenzhen Wei, Peicheng Luo, Wei Wei, Songqin Liu
Photodynamic therapy (PDT) is an effective and promising method for cancer treatment, which is proposed for more than one century. However, the specific delivery of photosensitizer to target carcinoma cells to reduce the side effect is still a great challenge. This work provides a strategy to deliver photosensitizers to cancer cells by utilizing pH-sensitive polyethylene glycol metal-phenolic network (PEG-MPN) capsules to encapsulate haematoporphyrin monomethyl ether (HMME). With the assistance of folic acid (FA), HMME-doped PEG-MPN capsules (MPN@HMMEs) accumulate in carcinoma cells selectively followed by releasing HMME in the lysosomes because of the physiologically relevant acidic pH environment...
September 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
Debora Bonvin, Jessica A M Bastiaansen, Matthias Stuber, Heinrich Hofmann, Marijana Mionić Ebersold
The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, very little has been reported for the targeting of nanomedicines to lymph node metastases (LNMs) of prostate cancer. We here report the simple and aqueous coating of iron oxide nanoparticles (IONPs) with FA for theranostics of LNMs of prostate cancer. FA was directly bound to the IONPs' surface without the use of any linker, simultaneously playing the role of the coating molecule and targeting agent...
September 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Pyeong Seok Choi, Jun Young Lee, Joung Hoon Park, Sang Wook Kim
(68) Ga is a positron-emitting radionuclide that can be combined with bifunctional chelating agents and bioactive substances for use as positron-emission tomography (PET) diagnostic agents. HBED-CC is an acyclic chelating agent that is rapidly labeled with (68) Ga under mild conditions. To target cancer cells, bioactive substances can be conjugated to the carboxyl terminus of HBED-CC. Because folic acid strongly binds to folate receptors that are overexpressed on the surfaces of many types of cancer cells, it was coupled with HBED-CC through a small polyethylene glycol-based linker (EDBE) to generate an active, receptor-selective targeting system...
September 13, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
Thiruganesh Ramasamy, Pasupathi Sundaramoorthy, Hima Bindu Ruttala, Yongjoo Choi, Woo Hyun Shin, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Hwan Mook Kim, Chul Soon Yong, Jong Oh Kim
Since breast cancer is one of the most lethal malignancies, targeted strategies are urgently needed. In this study, we report the enhanced therapeutic efficacy of docetaxel (DTX) when combined with polyunsaturated fatty acids (PUFA) for effective treatment of multi-resistant breast cancers. Folic acid (FA)-conjugated PUFA-based lipid nanoparticles (FA-PLN/DTX) was developed. The physicochemical properties, in vitro uptake, in vitro cytotoxicity, and in vivo anticancer activity of FA-PLN/DTX were evaluated. FA-PLN/DTX could efficiently target and treat human breast tumor xenografts in vivo...
November 2017: Drug Delivery
Xin Ji, Huilong Guo, Qiao Tang, Dong Ma, Wei Xue
Antitumor efficacy of methotrexate (MTX) is seriously limited due to its poor water solubility, nonspecific tumor distribution and low bioavailability. To overcome these obstacles, polyspermine (PSP) conjugated with MTX and folic acid (FA) as a novel targeted prodrug was designed and has been successfully synthesized using the amidation reaction. The strong hydrophilic properties of PSP made MTX well dispersed in water and the cellular uptake study indicated that the presence of FA enhanced uptake of the FA-PSP-MTX in folate receptor (FR) over-expressing human nasopharyngeal carcinoma HNE-1 cells...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Hadi Ranji-Burachaloo, Fatemeh Karimi, Ke Xie, Qiang Fu, Paul A Gurr, Dave E Dunstan, Greg G Qiao
A novel reduced iron metal-organic framework nanoparticle with cytotoxicity specific to cancer cells is presented. This nanoparticle was prepared via a hydrothermal method, reduced using hydroquinone, and finally conjugated with folic acid (namely, rMOF-FA). The synthesized nanoparticle shows the controlled release of iron in an acidic ex-vivo environment. Iron present on the rMOF-FA and released into solution can react with high levels of hydrogen peroxide found specifically in cancer cells to increase the hydroxyl radical concentration...
September 20, 2017: ACS Applied Materials & Interfaces
Fan Yang, Tingting Zhang, Shan-Shan Li, Pei Song, Kai Zhang, Qi-Yuan Guan, Bin Kang, Jing-Juan Xu, Hong-Yuan Chen
It is a great challenge to design a drug delivery system with controlled manner, especially, triggered by an exclusive endogenous disease marker and with an easily-tracked release process. Herein, we developed a drug delivery platform of carbon dots which connected to stem-loop molecular beacon loaded with doxorubicin and polyethylene glycol modified folic acid. Such platform enables to release drugs on demand under the stimuli of endogenous microRNA-21, and turn on the fluorescence of carbon dots and doxorubicin, which allows to monitor the drug release process...
September 8, 2017: Analytical Chemistry
Curtis J Henry, Travis Nemkov, Matias Casas-Selves, Ganna Bilousova, Vadym Zaberezhnyy, Kelly C Higa, Natalie J Serkova, Krik C Hansen, Angelo D' Alessandro, James DeGregori
While dietary folate deficiency is associated with increased risk for birth defects and other diseases, evidence suggests that supplementation with folic acid can contribute to predisposition to some diseases, including immune dysfunction and cancer. Here we show that diets supplemented with folic acid both below and above the recommended levels led to significantly altered metabolism in multiple tissues in mice. Surprisingly, both low and excessive dietary folate induced similar metabolic changes, which were particularly evident for nucleotide biosynthetic pathways in B-progenitor cells...
September 7, 2017: Haematologica
M Shahnawaz Khan, Abou Talib, Sunil Pandey, Mukesh L Bhaisare, Gangaraju Gedda, Hui-Fen Wu
Photothermal ablation of the cancer cells is a non-invasive technique for cancer treatment, involving cellular assassination in presence of photothermal agent. We are reporting silver selenide (Ag2Se) nanoparticles for photothermal therapy using folic acid for selective targeting. The material, when exposed to 808nm laser, the temperature got boosted to 54°C in 6.5min, thus proving its potential for photothermal ablation. The material was highly biocompatible (95%) at highest concentration (10μg/mL) against A 549 cells...
July 27, 2017: Colloids and Surfaces. B, Biointerfaces
Trang Huyen Le Kim, Jeong Heon Yu, Hwiseok Jun, Moon Young Yang, Mi-Jin Yang, Jae-Woo Cho, Jin Woong Kim, Jee Seon Kim, Yoon Sung Nam
Despite the excellent biocompatibility and antifouling effect of poly(ethylene glycol) (PEG), the high steric hindrance, limited chemical functionality, and low ligand multivalency of PEGylated nanocarriers often lead to inefficient cell targeting and intracellular trafficking. Hence, a new structure of hydrophilic corona allowing a higher ligand density without loss of excellent biocompatibility is highly desirable. Here we introduce tumor-targeted polyglycerolated (PGylated) nanocarriers that dramatically enhance the in vivo therapeutic efficacy of incorporated paclitaxel simply by increasing the surface density of hydrophobic tumor-targeting ligands...
August 29, 2017: Biomaterials
Fatma Demir Duman, Merve Erkisa, Rouhullah Khodadust, Ferda Ari, Engin Ulukaya, Havva Yagci Acar
AIM: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. MATERIALS & METHODS: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells...
September 6, 2017: Nanomedicine
Fahimeh Charbgoo, Mehrdad Behmanesh, Maryam Nikkhah
Advances in nanobiotechnology and targeting strategy could improve the delivery of therapeutic molecules into cancer cells, leading to improved treatment efficiency with minimal side effects on normal cells. To design an efficient nanocarrier, consideration of parameters that facilitate direct drug delivery into the target cells is important. We studied the effect of single wall carbon nanotubes size on their cell internalization level via the folate receptor-mediated pathway through folic acid targeting. Folate-SWNTs were covalently synthesized and characterized...
August 30, 2017: Biotechnology and Applied Biochemistry
Limei Cai, Rufen Yu, Xi Hao, Xiangcui Ding
In this study, novel folic acid-conjugated chitosan nanoparticle was formulated for specific delivery of bioflavonoid, Genistein (GEN), to the cervical cancer cells. The prepared GEN-loaded chitosan nanoparticles (GCN) and folic acid-conjugated GCN (FGCN) showed smaller size with a controlled drug release profile. FGCN exhibited enhanced internalization potential in HeLa cells than that of GCN. The specific internalization of FGCN was mainly due to the affinity of folic acid (FA) with FRs-α which is present in large numbers in HeLa cells...
August 29, 2017: Nanoscale Research Letters
Qi Zhang, LingYu Zhang, Shengnan Li, Xiangjun Chen, Manjie Zhang, Tingting Wang, Lu Li, Chungang Wang
Elaborately designed novel multifunctional Janus nanoparticles (JNPs) have attracted considerable attention owing to their anisotropic surface properties and various functionalities that allow them to house several components for cancer cells detection and targeting. In this work, we report a novel and facile approach to synthesize Au/Fe3O4@C JNPs, which were further selectively functionalized with amino-poly(ethylene glycol)thiol (NH2-PEG-SH) and folic acid (FA) on the exposed Au domains to achieve high contrast for X-ray computed tomography (CT) imaging, excellent stability, good biocompatibility as well as cancer cell-specific targeting, while the other Fe3O4@C sides with mesoporous structure served as the drug delivery vehicle of doxorubicin (DOX), efficient photothermal therapy (PTT) agent and magnetic resonance (MR) imaging contrast agent...
August 28, 2017: Chemistry: a European Journal
Zheng Wang, Zhimin Chang, Mengmeng Lu, Dan Shao, Juan Yue, Dian Yang, Mingqiang Li, Wen-Fei Dong
Stimuli-triggered nanoplatforms have become attractive candidates for combined strategies for advanced liver cancer treatment. In this study, we designed a light-responsive nanoplatform with folic acid-targeting properties to surmount the poor aqueous stability and photostability of indocyanine green (ICG). In this Janus nanostructure, ICG was released on-demand from mesoporous silica compartments in response to near-infrared (NIR) irradiation, exhibiting predominant properties to convert light to heat in the cytoplasm to kill liver cancer cells...
September 13, 2017: ACS Applied Materials & Interfaces
Qiang Wu, Yining Lin, Fangjie Wo, Yufeng Yuan, Qingling Ouyang, Jun Song, Junle Qu, Ken-Tye Yong
Magnetic-luminescent nanocomposites have multiple uses including multimodal imaging, magnetic targeted drug delivery, and cancer imaging-guided therapies. In this work, dumbbell-like MnFe2 O4 -NaYF4 Janus nanoparticles are synthesized via a two-step thermolysis approach. These synthesized nanoparticles exhibit stability in aqueous solutions and very low cytotoxicity after poly(acryl amide) modification. High cellular uptake efficiency is observed for the folic acid-conjugated MnFe2 O4 -NaYF4 in human esophagus carcinoma cells (Eca-109) due to the upconversion luminescence properties as well as the folate targeting potential...
August 21, 2017: Small
Melissa N Zimel, Chloe B Horowitz, Vinagolu K Rajasekhar, Alexander B Christ, Xin Wei, Jianbo Wu, Paulina M Wojnarowicz, Dong Wang, Steven R Goldring, P Edward Purdue, John H Healey
Polymeric nanocarriers such as N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers deliver drugs to solid tumors and avoid the systemic toxicity of conventional chemotherapy. Because HPMA copolymers can target sites of inflammation and accumulate within innate immune cells, we hypothesized that HPMA copolymers could target tumor-associated macrophages (TAMs) in both primary and metastatic tumor microenvironments. We verified this hypothesis, first in preliminary experiments with isolated bone marrow macrophage cultures in vitro, and subsequently in a spontaneously metastatic murine breast cancer model generated from a well-established, cytogenetically characterized 4T1 breast cancer cell line...
August 22, 2017: Molecular Cancer Therapeutics
Ningning Ma, Peidang Liu, Nongyue He, Ning Gu, Fu-Gen Wu, Zhan Chen
A major challenge to achieve effective X-ray radiation therapy is to use a relatively low and safe radiation dose. Various radiosensitizers, which can significantly enhance the radiotherapeutic performance, have been developed. Gold-based nanomaterials, as a new type of nanoparticle-based radiosensitizers, have been extensively used in researches involving cancer radiotherapy. However, the cancer therapeutic effect using the gold nanoparticle-based radiotherapy is usually not significant because of the low cellular uptake efficiency and the autophagy-inducing ability of these gold nanomaterials...
September 20, 2017: ACS Applied Materials & Interfaces
Justyna Fraczyk, Malgorzata Walczak, Lukasz Szymanski, Zbigniew Kolacinski, Henryk Wrzosek, Ireneusz Majsterek, Karolina Przybylowska-Sygut, Zbigniew J Kaminski
AIM: Anchoring folic acid (FA) with a biomimetic peptidic linker resistant to proteolytic degradation to act as a homing device on functionalized carbon nanotubes. MATERIALS & METHODS: Ethylenediamine was attached to oxidized multiwalled carbon nanotubes (MWNTs) using 4-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methylmorpholinium tetrafluoroborate. FA was coupled with 6-aminohexanoic acid and derivatives of β-alanine, affording four intermediates, which connected to the MWNTs via peptidic linkers of various lengths...
August 17, 2017: Nanomedicine
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