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folic acid and cancer

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https://www.readbyqxmd.com/read/28643525/folic-acid-conjugated-nanoliposomes-as-promising-carriers-for-targeted-delivery-of-bleomycin
#1
Mohsen Chiani, Dariush Norouzian, Mohammad Ali Shokrgozar, Kayhan Azadmanesh, Aazam Najmafshar, Mohammad Reza Mehrabi, Azim Akbarzadeh
Targeted drug delivery has received considerable attention due to its key role in improving therapeutic efficacy and reducing the side effects of anticancer drugs. Bleomycin (BLM) is an anticancer antibiotic with short half-life, low therapeutic and high side effects that limit its clinical applications. This study aims to evaluate the anticancer potential of folate-targeted liposomal bleomycin (FL-BLM) and its free-folate form (L-BLM) on two different cancer cell lines including human cervix carcinoma HeLa, and human breast carcinoma MCF-7 cells...
June 23, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28643511/exceptionally-high-payload-of-ir780-iodide-on-folic-acid-functionalized-graphene-quantum-dots-for-targeted-photothermal-therapy
#2
Shuhua Li, Shixin Zhou, Yunchao Li, Xiaohong Li, Jia Zhu, Louzhen Fan, Shihe Yang
IR780 iodide (IR780) is recognized as an effective theranostic agent for simultaneous near-infrared (NIR) fluorescence imaging and photothermal therapy (PTT). However, the rigid chloro-cyclohexenyl ring makes IR780 insoluble in almost all pharmaceutically acceptable solvents, which inevitably limits its clinical application. We report folic acid (FA)-functionalized graphene quantum dots (GQDs-FA) containing a large and intact sp2-domain with carboxyl groups around the edge. Such GQDs-FA possess exceptionally high loading capacity for IR780 via strong π-π stacking interactions, and the water solubility of IR780 is improved by over 2400-fold after loading onto GQDs-FA (IR780/GQDs-FA)...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28632263/fabrication-of-a-graphene-c60-nanohybrid-via-%C3%AE-cyclodextrin-host-guest-chemistry-for-photodynamic-and-photothermal-therapy
#3
Zhen Hu, Cheng Wang, Feng Zhao, Xirong Xu, Shuhong Wang, Long Yu, Dayu Zhang, Yudong Huang
The wonderful chemical structures and characteristics of low-dimensional carbon materials have exciting applications in life sciences. In the present study, we developed a facile strategy to conjugate C60 with graphene via host-guest chemistry for targeted phototherapy. A versatile carrier based on folic acid-functionalized graphene (GO-FA) and comprising γ-cyclodextrin (γ-CD) at its surface was assembled via π-π interaction, creating hybrid structures with drug storage and tumor targeting properties. This γ-CD-modified graphene (GO-FA/Py-γ-CD) is capable of hosting pristine C60 molecules for the fabrication of a GO-FA/Py-γ-CD/C60 nanohybrid...
June 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28627503/three-layered-polyplex-as-a-microrna-targeted-delivery-system-for-breast-cancer-gene-therapy
#4
Yan Li, Yu Dai, Xiaojin Zhang, Jihua Chen
MicroRNAs (miRNAs), small non-coding RNAs, play an important role in modulating cell proliferation, migration, and differentiation. Since miRNAs can regulate multiple cancer-related genes simultaneously, regulating miRNAs could target a set of related oncogenic genes or pathways. Owing to their reduced immune response and low toxicity, miRNAs with small size and low molecular weight have become increasingly promising therapeutic drugs in cancer therapy. However, one of the major challenges of miRNAs-based cancer therapy is to achieve specific, effective, and safe delivery of therapeutic miRNAs into cancer cells...
June 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28616960/functional-build-in-template-directed-siliceous-fluorescent-supramolecular-vesicles-as-diagnostics
#5
Jie Li, Kaerdun Liu, Hengyu Chen, Ruoyan Li, Markus Drechsler, Fan Bai, Jianbin Huang, Ben Zhong Tang, Yun Yan
Functional template directed synthesis of hybrid siliceous fluorescent vesicle (HSFV) is fabricated by using fluorescent vesicle as a build-in template. The template vesicle is the ionic self-assembly of an aggregation-induced emission (AIE) fluorogen. Upon depositing folic acid modified silica shell on its surface, the obtained HSFVs display low cytotoxicity, significant fluorescence and targeted drug delivery toward cancer cells. Furthermore, the wall-thickness of the HSFVs can be controlled via altered concentration of silica source...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28608677/block-copolymer-based-nanoparticles-for-theranostic-intervention-of-cervical-cancer-synthesis-pharmacokinetics-and-in-vitro-in-vivo-evaluation-in-hela-xenograft-models
#6
Shweta Dumoga, Yogesh Rai, Anant Narayan Bhatt, Anjani Kumar Tiwari, Surendra Singh, Anil Kumar Mishra, Dipti Kakkar
Polymer based nanoparticles have proven to be viable carriers of therapeutic agents. In this study we have developed nanoparticles (NPs) from polypeptide-polyethylene glycol based triblock and diblock copolymers. The synthesized block copolymers Poly (ethylene glycol)-b-Poly (glutamic acid)-b- Poly (ethylene glycol) (GEG) and Poly (ethylene glycol)-b-Poly (glutamic acid) (EG) conjugated with folic acid for targeting specificity (EGFA), have been used to encapsulate methotrexate (MTX) to form M-GEG and M-EGFA nanoparticles (NPs) aimed at passive and active targeting of cervical carcinoma...
June 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28606519/folate-conjugated-thermosensitive-o-maleoyl-modified-chitosan-micellar-nanoparticles-for-targeted-delivery-of-erlotinib
#7
Marziyeh Fathi, Parham Sahandi Zangabad, Ayuob Aghanejad, Jaleh Barar, Hamid Erfan-Niya, Yadollah Omidi
In the present work, new self-assembled nanoparticles (NPs) were engineered using biocompatible and biodegradable natural polymer, chitosan (CS). The complexation of CS with sodium dodecyl sulfate (SDS) facilitated the regioselective chemical modification of CS hydroxyl groups with maleic anhydride, and produced polymerizable precursor of CS that was further grafted with N-isopropylacrylamide (NIPAAm) as temperature-sensitive moiety and oleic acid (OA) as hydrophobic monomer. After removal of SDS complex, the free amino groups were functionalized with folic acid (FA) to form folate-(PNIPAAm-co-OA)-g-CS micellar NPs...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28604596/optimized-photodynamic-therapy-with-multifunctional-cobalt-magnetic-nanoparticles
#8
Kyong-Hoon Choi, Ki Chang Nam, Un-Ho Kim, Guangsup Cho, Jin-Seung Jung, Bong Joo Park
Photodynamic therapy (PDT) has been adopted as a minimally invasive approach for the localized treatment of superficial tumors, representing an improvement in the care of cancer patients. To improve the efficacy of PDT, it is important to first select an optimized nanocarrier and determine the influence of light parameters on the photosensitizing agent. In particular, much more knowledge concerning the importance of fluence and exposure time is required to gain a better understanding of the photodynamic efficacy...
June 10, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28603928/the-nutritional-role-of-folate
#9
REVIEW
Shuhei Ebara
Folate functions as a coenzyme to transfer one-carbon units that are necessary for deoxythymidylate synthesis, purine synthesis, and various methylation reactions. Ingested folate becomes a functional molecule through intestinal absorption, circulation, transport to cells, and various modifications to its structure. Associations between nutritional folate status and chronic diseases such as cardiovascular disease, cancer, and cognitive dysfunction have been reported. It has also been reported that maternal folate nutritional status is related to the risk of neural tube defects (NTDs) in the offspring...
June 11, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28593987/spaser-as-a-biological-probe
#10
Ekaterina I Galanzha, Robert Weingold, Dmitry A Nedosekin, Mustafa Sarimollaoglu, Jacqueline Nolan, Walter Harrington, Alexander S Kuchyanov, Roman G Parkhomenko, Fumiya Watanabe, Zeid Nima, Alexandru S Biris, Alexander I Plekhanov, Mark I Stockman, Vladimir P Zharov
Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28589526/a-large-inner-diameter-multi-walled-carbon-nanotube-based-dual-drug-delivery-system-with-ph-sensitive-release-properties
#11
Tao Yang, Zhenzhen Wu, Pingting Wang, Tingting Mu, Han Qin, Zhimin Zhu, Jian Wang, Lei Sui
A novel dual-drug delivery system (DDDS) for cancer chemotherapy has been established by employing highly purified and mildly oxidized large-inner-diameter multi-walled carbon nanotubes (LID-MWCNTs) as the vector. The LID-MWCNTs were modified with the antitumor drugs, cisplatin (CDDP) and doxorubicin (DOX). CDDP was encapsulated inside the nanotube vectors by a wet-chemical approach while DOX was attached to the external surfaces through non-covalently interaction. The loading efficiencies of CDDP and DOX were as high as 84...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28588742/folate-deficiency-as-predisposing-factor-for-childhood-leukaemia-a-review-of-the-literature
#12
REVIEW
Catia Daniela Cantarella, Denise Ragusa, Marco Giammanco, Sabrina Tosi
BACKGROUND: Folic acid and its derivates, known as folates, are chemoprotective micronutrients of great interest because of their essential role in the maintenance of health and genomic integrity. The supplementation of folic acid during pregnancy has long been known to reduce the risk of neural tube defects (NTDs) in the foetus. Folate metabolism can be altered by many factors, including adequate intake through diet. Folate deficiency can compromise the synthesis, repair and methylation of DNA, with deleterious consequences on genomic stability and gene expression...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28586102/enhancing-photodynamic-therapy-through-resonance-energy-transfer-constructed-near-infrared-photosensitized-nanoparticles
#13
Ling Huang, Zhanjun Li, Yang Zhao, Jinyi Yang, Yucheng Yang, Aarushi Iris Pendharkar, Yuanwei Zhang, Sharon Kelmar, Liyong Chen, Wenting Wu, Jianzhang Zhao, Gang Han
Photodynamic therapy (PDT) is an important cancer treatment modality due to its minimally invasive nature. However, the efficiency of existing PDT drug molecules in the deep-tissue-penetrable near-infrared (NIR) region has been the major hurdle that has hindered further development and clinical usage of PDT. Thus, herein a strategy is presented to utilize a resonance energy transfer (RET) mechanism to construct a novel dyad photosensitizer which is able to dramatically boost NIR photon utility and enhance singlet oxygen generation...
June 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28585624/exploiting-the-biomimetic-and-luminescence-properties-of-multivalent-dendrimer-semiconductor-nanohybrid-materials-in-the-ultra-low-level-determination-of-folic-acid
#14
Somashree Kundu, Susmita Maiti, Tushar Kanti Das, Debasmita Ghosh, Chandra Nath Roy, Abhijit Saha
In view of the enhanced generation of folate receptors in cancerous cells and diseases linked to the deficiency of folic acid, such as anemia, mental devolution, congenital malformation, etc., the development of a simple method for the ultra-sensitive determination of folic acid remains a long-standing issue for practical applications in medicine and biotechnology. Thus, the proposed luminescence based strategy involving multifunctional poly(amidoamine) (PAMAM) dendrimer encapsulated quantum dots (QDs) as a probe provides a simple, fast and efficient method for the selective determination of folic acid at the nano-molar level...
June 6, 2017: Analyst
https://www.readbyqxmd.com/read/28583295/chlorin-e6-conjugated-silica-nanoparticles-for-targeted-and-effective-photodynamic-therapy
#15
Subramaniyan Bharathiraja, Madhappan Santha Moorthy, Panchanathan Manivasagan, Hansu Seo, Kang Dae Lee, Junghwan Oh
Photodynamic therapy (PDT) using photosensitizer drug becomes important therapeutic modality in recent days. However, the stability and targeted delivery of photosensitizer remain critical challenge for efficient PDT treatment. In the present study, we developed chlorin e6 (Ce6)-conjugated and folic acid (FA)-decorated silica nanoparticles (silica-Ce6-FA) for targeted delivery of photosensitizer to the cancer cells. The synthesized NPs exhibited excellent stability and biocompatibility with MDA-MB-231 cells...
June 2, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28580592/shape-controlled-hollow-mesoporous-silica-nanoparticles-with-multifunctional-capping-for-in-vitro-cancer-treatment
#16
Hongya Geng, Weiyu Chen, Ping Zhi Xu, Guangren Qian, Jing An, Haijiao Zhang
In the work, we prepare a series of multifunctional shape-controlled non-spherical hollow mesoporous silica nanoparticles (HMSNs) drug carriers by employing Fe2O3 with four morphologies (capsule, cube, rice and rhombus) as sacrificial template and multifunctional cap as the encapsulating shell, respectively. The resulting shape-controlled non-spherical HMSNs perfectly replicate the origin morphology of Fe2O3 templates, possessing high specific surface area, good monodispersity, perpendicular mesoporous channel and excellent biocompatibility...
June 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28580313/the-effect-of-inflammatory-status-on-butyrate-and-folate-uptake-by-tumoral-caco-2-and-non-tumoral-iec-6-intestinal-epithelial-cells
#17
Mafalda R Couto, Pedro Gonçalves, Telmo A Catarino, Fátima Martel
OBJECTIVE: Colorectal cancer (CRC) is the second leading cause of cancer death in occidental countries. Chronic inflammatory bowel disease (crohn's disease and ulcerative colitis) is associated with an increased risk for CRC development. The aim of this work was to investigate the relationship between inflammatory status and absorption of nutrients with a role in CRC pathogenesis. MATERIALS AND METHODS: In this experimental study, we evaluated the in vitro effect of tumour necrosis factor-alpha (TNF-α), interferon-γ (IF-γ), and acetylsalicylic acid on 14C-butyrate (14C- BT), 3H-folic acid (3H-FA) uptake, and on proliferation, viability and differentiation of Caco-2 and IEC-6 cells in culture...
2017: Cell Journal
https://www.readbyqxmd.com/read/28575948/synthesis-characterization-and-biological-evaluation-of-alginate-nanoparticle-for-the-targeted-delivery-of-curcumin
#18
Thayyath Sreenivasan Anirudhan, Manasa Mohan Anila, Shainy Franklin
Cancer continues to be a serious disaster to mankind. Chemotherapy is an efficient and effective treatment against cancer. Lack of selectivity is the main challenge faced by chemotherapy. In present study we used folic acid (FA) as a targeting ligand, which selectively targets the cancer cell lines with over expressed folate receptors (FR). We grafted polyethylene glycol (PEG) to polyethylene imine (PEI) to form PEG-b-PEI (mPPS), which is then coupled with FA to form FA- PEG-b-PEI (PPF) which is then assembled with curcumin (CUR) loaded alginate nanoparticle (AlgNP)...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28575942/hybrid-znpc-tio2-nanostructures-for-targeted-photodynamic-therapy-bioimaging-and-doxorubicin-delivery
#19
Dorota Flak, Luis Yate, Grzegorz Nowaczyk, Stefan Jurga
In this study ZnPc@TiO2 hybrid nanostructures, both nanoparticles and nanotubes, as potential photosensitizers for the photodynamic therapy, fluorescent bioimaging agents, as well as anti-cancer drug nanocarriers, were prepared via zinc phthalocyanine (ZnPc) deposition on TiO2. In order to provide the selectivity of prepared hybrid nanostructures towards cancer cells they were modified with folic acid molecules (FA). The efficient attachment of both ZnPc and FA molecules was confirmed with dynamic light scattering (DLS), zeta potential measurements and X-ray photoelectron spectroscopy (XPS)...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28571542/folic-acid-targeted-polymeric-micelles-based-on-tocopherol-succinate-pulluan-as-an-effective-carrier-for-epirubicin-preparation-characterization-and-in-vitro-cytotoxicity-assessment
#20
Farshid Hassanzadeh, Mozhdeh Mehdifar, Jaleh Varshosaz, Ghadam Ali Khodarahmi, Mahboubeh Rostami
BACKGROUND: Chemotherapy still encounters a serious drawback, the lack of selectivity of anticancer drugs toward neoplastic cells, thus, the normal cells are affected by the cytotoxic action of the drugs. This causes a narrow therapeutic index in most anticancer drugs. OBJECTIVE: We describe here the preparation of pullulan-tocopherol succinate-folic acid (Pu-TS-FA) micelles for the first time to targeted delivery of epirubicin (EPI) to Hela and MCF-7 cell lines...
June 1, 2017: Current Drug Delivery
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