Haiping Wang, Yibin Zhang, Xiaoqian Rong, Boling Wang, Li Wang, Chen Wang, Wanxia Gao, Xiansheng Ye, Xiaoying Hou, Wei Liu, Meihui Wu, Yueting Cheng, Xiji Shu, Jinting Shang
This study investigated the potential ability of the fluorescent probe Ly-CHO to detect formaldehyde (FA) in living cells and tumor-bearing mice. Ly-CHO exhibited great selectivity, excellent sensitivity, and rapid response to FA, making it a valuable tool for tracking FA concentration changes. The probe was also found to target lysosomes specifically. Furthermore, Ly-CHO showed an obvious fluorescence increase in endogenous CHO detection after adding tetrahydrogen folic acid (THFA). This study validated Ly-CHO's possibility for FA imaging in vivo, with potential applications in understanding formaldehyde-related diseases...
March 5, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy