keyword
https://read.qxmd.com/read/38536555/folate-induces-stemness-and-increases-oxygen-consumption-under-glucose-deprivation-by-notch-1-pathway-activation-in-colorectal-cancer-cell
#1
JOURNAL ARTICLE
Juan Rodríguez Silva, Matías Monsalves-Álvarez, Carlos Sepúlveda, Camila Donoso-Barraza, Rodrigo Troncoso, Sandra Hirsch
Evidence for folate's protective effects on neural tube defects led the USA and Chile to start mandatory folic acid (FA) fortification programs, decreasing up to 50%. However, ∼30% of the population consuming fortified foods reach supraphysiologic serum levels. Although controversial, several epidemiological and clinical observations suggest that folate increases cancer risk, giving concern about the risks of FA supplementation. The Cancer stem cells (CSCs) model has been used to explain survival to anticancer therapies...
March 27, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38535267/a-comprehensive-study-on-folate-targeted-mesoporous-silica-nanoparticles-loaded-with-5-fluorouracil-for-the-enhanced-treatment-of-gynecological-cancers
#2
JOURNAL ARTICLE
Aliyah Almomen, Adel Alhowyan
BACKGROUND: Gynecological cancers are a significant public health concern, accounting for 40% of all cancer incidence and 30% of deaths in women. 5-Fluorouracil (5-FU) can be used with chemotherapy to improve treatment in advanced-stage gynecological cancer. Mesoporous silica nanoparticles (MSNs) can improve drug effectiveness and reduce toxicity. Folic acid can target folate receptors in epithelial malignancies like ovarian and cervical cancer. METHODS: The mixture of MSN-NH2 was synthesized by dissolving N-lauroylsarcosine sodium in a water-ethanol mixture, adding APTES and TEOS, and heating at 80 °C for 18 h, before being fully characterized...
March 20, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38530292/folate-mediated-targeting-and-controlled-release-plga-encapsulated-mesoporous-silica-nanoparticles-delivering-capecitabine-to-pancreatic-tumor
#3
REVIEW
Abhay Dev Tripathi, Yamini Labh, Soumya Katiyar, Anurag Kumar Singh, Vivek K Chaturvedi, Abha Mishra
The discovery of specifically tailored therapeutic delivery systems has sparked the interest of pharmaceutical researchers considering improved therapeutic effectiveness and fewer adverse effects. The current study concentrates on the design and characterization of PLGA (polylactic-co-glycolic acid) capped mesoporous silica nanoparticles (MSN)-based systems for drug delivery for pH-sensitive controlled drug release in order to achieve a targeted drug release inside the acidic tumor microenvironment. The physicochemical properties of the nanoformulations were analyzed using TEM, zeta potential, AFM, TGA, FTIR, and BET analyses in addition to DLS size...
March 26, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38520338/immunoantitumor-activity-and-oxygenation-effect-based-on-iron-copper-doped-folic-acid-carbon-dots
#4
JOURNAL ARTICLE
Siqi Li, Hui Zhang, Yujun Bao, Huanli Zhang, Jingchun Wang, Mingyang Liu, Rui Yan, Zhiqiang Wang, Xiaodan Wu, Yingxue Jin
Cancer metastasis and recurrence are closely associated with immunosuppression and a hypoxic tumor microenvironment. Chemodynamic therapy (CDT) and photothermodynamic therapy (PTT) have been shown to induce immunogenic cell death (ICD), effectively inhibiting cancer metastasis and recurrence when combined with immune adjuvants. However, the limited efficacy of Fenton's reaction and suboptimal photothermal effect present significant challenges for successfully inducing ICD through CDT and PTT. This paper described the synthesis and immunoantitumor activity of the novel iron-copper-doped folic acid carbon dots (CFCFB)...
March 23, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38492845/combined-photothermal-therapy-and-cancer-immunotherapy-by-immunogenic-hollow-mesoporous-silicon-shelled-gold-nanorods
#5
JOURNAL ARTICLE
Keyue Cao, Yao Zhou, Ying Shen, Yifei Wang, Haiqin Huang, Hongyan Zhu
Hyperthermia can be integrated with tumor-killing chemotherapy, radiotherapy and immunotherapy to give rise to an anti-tumor response. To this end, a nano-delivery system is built, which can connect hyperthermia and immunotherapy. On this basis, the impact of such a combination on the immune function of dendritic cells (DCs) is explored. The core of this system is the photothermal material gold nanorod (GNR), and its surface is covered with a silica shell. Additionally, it also forms a hollow mesoporous structure using the thermal etching approach, followed by modification of targeted molecule folic acid (FA) on its surface, and eventually forms a hollow mesoporous silica gold nanorod (GNR@void@mSiO2) modified by FA...
March 14, 2024: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38479563/synthesis-of-folate-targeted-theranostic-cubosomal-platform-for-co-delivery-of-bismuth-oxide-and-doxorubicin-to-melanoma-in-vitro-and-in-vivo
#6
JOURNAL ARTICLE
Mahsa Zahiri, Hosein Kamali, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Negar Nekooei, Mohammad Ramezani, Mona Alibolandi
Liquid crystalline nanoparticles (LCNPs) have gained much attention in cancer nanomedicines due to their unique features such as high surface area, storage stability, and sustained-release profile. In the current study, a novel LCNP for co-encapsulation of Bi2 O3 and hydrophilic doxorubicin (DOX) was fabricated and functionalized with folic acid (FA) to achieve efficient tumor targeting toward CT-scan imaging and chemotherapy of melanoma in vitro and in vivo. LCNPs Bi2 O3 NPs were prepared using glycerol monooleate-pluronic F-127 (GMO/PF127/water)...
March 11, 2024: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/38463259/formulation-of-folate-receptor-targeted-silibinin-loaded-inhalable-chitosan-nanoparticles-by-the-qbd-approach-for-lung-cancer-targeted-delivery
#7
JOURNAL ARTICLE
Priya Patel, Mihir Raval, Vishal Airao, Nemat Ali, Gamal A Shazly, Rehan Khan, Bhupendra Prajapati
Aim : Targeted delivery of chemotherapeutics by functionalized nanoparticles exhibits a wonderful prospect for cancer treatment. The main objective of this research was to develop folate receptor-targeted silibinin (SB)-loaded inhalable polymeric nanoparticles (FA-CS-SB-NPs) for the treatment of lung cancer. Method : The qbD approach was implemented to prepare SB-loaded nanoparticles. Folic acid was conjugated by electrostatic conjugation in an optimized batch. The therapeutic potentials of formulations were determined using a lung cancer cell-bearing rat model...
March 5, 2024: ACS Omega
https://read.qxmd.com/read/38461560/a-novel-lysosome-targeted-fluorescent-probe-for-precise-formaldehyde-detection-in-water-samples-living-cells-and-breast-cancer-tumors
#8
JOURNAL ARTICLE
Haiping Wang, Yibin Zhang, Xiaoqian Rong, Boling Wang, Li Wang, Chen Wang, Wanxia Gao, Xiansheng Ye, Xiaoying Hou, Wei Liu, Meihui Wu, Yueting Cheng, Xiji Shu, Jinting Shang
This study investigated the potential ability of the fluorescent probe Ly-CHO to detect formaldehyde (FA) in living cells and tumor-bearing mice. Ly-CHO exhibited great selectivity, excellent sensitivity, and rapid response to FA, making it a valuable tool for tracking FA concentration changes. The probe was also found to target lysosomes specifically. Furthermore, Ly-CHO showed an obvious fluorescence increase in endogenous CHO detection after adding tetrahydrogen folic acid (THFA). This study validated Ly-CHO's possibility for FA imaging in vivo, with potential applications in understanding formaldehyde-related diseases...
March 5, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38453551/corrigendum-to-dual-targeting-nanoparticles-based-on-hyaluronic-and-folic-acids-as-a-promising-delivery-system-of-the-encapsulated-4-methylumbelliferone-4-mu-against-invasiveness-of-lung-cancer-in-vivo-and-in-vitro-int-j-biol-macromol-206-2022-467-480
#9
Marwa Labib Essa, Aya A Elashkar, Nemany A N Hanafy, Eman M Saied, Maged El-Kemary
No abstract text is available yet for this article.
March 6, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38452835/synthesis-and-biological-evaluation-of-folic-acid-rotenol-conjugate-as-a-potent-targeted-anticancer-prodrug
#10
JOURNAL ARTICLE
Min Hong, Juan Wang, Haobin Chen, Jiayu Qi, Qinghong Ji, Xiaoyan Liu, Qiaoli Yue, Lei Li, Shuang Cheng
Rotenone, a plant-based agricultural insecticide, has been shown to have anti-tumor activity through targeting mitochondrial complex I in cancer cells. However, off-target toxic side effect on nervous systems have greatly restricted the application of rotenone as anticancer drugs. Here, a folic acid-rotenol (FA-rotenol) conjugate was prepared by covalent coupling of the tumor-targeting ligand folic acid with rotenone derivative-rotenol to enhance its accumulation at tumor site. FA-rotenol conjugates presents high in vitro cytotoxicties against several cell lines by inducing mitochondrial membrane potential depolarization and increasing the level of intracellular reactive oxygen species (ROS) to activate the mitochondrial pathway of apoptosis and enhance the G2/M cell cycle arrest...
March 5, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38452833/appraisal-of-folate-functionalized-bosutinib-cubosomes-against-hepatic-cancer-cells-in-vitro-in-silico-and-in-vivo-pharmacokinetic-study
#11
JOURNAL ARTICLE
Raquibun Nisha, Pranesh Kumar, Nidhi Mishra, Priyanka Maurya, Shakir Ahmad, Neelu Singh, Shubhini A Saraf
Targeted therapies enhance the efficacy of tumour screening and management while lowering side effects. Multiple tumours, including liver cancer, exhibit elevated levels of folate receptor expression. This research attempted to develop surface-functionalised bosutinib cubosomes against hepatocellular carcinoma. The novelty of this work is the anti-hepatic action of bosutinib (BST) and folic acid-modified bosutinib cubosomes (BSTMF) established through proto-oncogene tyrosine-protein kinase (SrC)/ focal adhesion kinase(FAK), reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and cell cytotoxicity...
March 5, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38444739/chitosan-nanoplatform-for-the-co-delivery-of-palbociclib-and-ultra-small-magnesium-nanoclusters-dual-receptor-targeting-therapy-and-imaging
#12
JOURNAL ARTICLE
Abhishesh Kumar Mehata, Virendra Singh, Vikas, Prachi Srivastava, Biplob Koch, Manoj Kumar, Madaswamy S Muthu
Theranostic nanoparticles have gained significant attention in cancer diagnosis and therapy. In this study, estrone (ES) and folic acid (FA) functionalized single and dual receptor targeted theranostic chitosan nanoparticles were developed for breast cancer imaging and therapy. These nanoparticles (NPs) were loaded with palbociclib (PB) and ultra-small magnesium nanoclusters (UMN). The developed nontargeted theranostic NPs (PB-UMN-CS-NPs), estrogen receptor targeted theranostic NPs (PB-UMN-CS-ES-NPs), folate receptor targeted theranostic NPs (PB-UMN-CS-FA-NPs), and dual targeted theranostic NPs (PB-UMN-CS-ES-FA-NPs) have particle sizes of 178...
2024: Nanotheranostics
https://read.qxmd.com/read/38433936/folate-conjugated-albumin-as-a-targeted-nanocarrier-for-the-delivery-of-fisetin-in-silico-and-in-vitro-biological-studies
#13
JOURNAL ARTICLE
Raghu Solanki, Amit Kumar Srivastav, Sejal Patel, Sanju Kumari Singh, Bhavana Jodha, Umesh Kumar, Sunita Patel
Fisetin (FST), a natural flavonoid compound derived from various fruits and vegetables, including apple, strawberry, and onion, demonstrates potential for a wide range of pharmaceutical applications, including potential anticancer properties. However, challenges such as low bioavailability, poor aqueous solubility, and limited permeability restrict the use of FST in the pharmaceutical sector. Nowadays, targeted nanomedicines have garnered attention to overcome limitations associated with phytochemicals, including FST...
February 29, 2024: RSC Advances
https://read.qxmd.com/read/38418381/tumor-microenvironment-regulating-two-photon-probe-based-on-bimetallic-post-coordinated-mof-facilitating-the-dual-modal-and-deep-imaging-guided-synergistic-therapies
#14
JOURNAL ARTICLE
Yanjun Liu, Lu Wang, Tong Zhang, Chunya Wang, Yifan Fan, Congcong Wang, Nan Song, Ping Zhou, Chun-Hua Yan, Yu Tang
The intricate tumor microenvironment (TME) always brings about unsatisfactory therapeutic effects for treatments, although nanomedicines have been demonstrated to be highly beneficial for synergistic therapies to avoid the side effects caused by the complexity and heterogeneity of cancer. Developing nanotheranostics with the functionalities of both synergistic therapies and TME regulation is a good strategy but is still in its infancy. Herein, an "all-in-one" nanoplatform for integrated diagnosis and treatment, namely, Carrier@ICG@DOX@FA (CIDF), is constructed...
February 28, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38414527/efficient-sequential-co-delivery-nanosystem-for-inhibition-of-tumor-and-tumor-associated-fibroblast-induced-resistance-and-metastasis
#15
JOURNAL ARTICLE
Chunhong Li, Zhen Wang, Yifeng Zhang, Yuqing Zhu, Maochang Xu, Hui Lei, Dan Zhang
PURPOSE: Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer. However, the effect of current treatment strategies by inducing tumor cell apoptosis alone is not satisfactory. The growth, metastasis and treatment sensitivity of tumors can be strongly influenced by cancer-associated fibroblasts (CAFs) in the microenvironment. Effective cancer therapies may need to target not only the tumor cells directly but also the CAFs that protect them. METHODS: Celastrol and small-sized micelles containing betulinic acid were co-encapsulated into liposomes using the thin-film hydration method (CL@BM)...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38403143/enhancement-of-the-effect-of-novel-targeted-5-aminolevulinic-acid-conjugated-bismuth-oxide-nanoparticles-based-photodynamic-therapy-by-simultaneous-radiotherapy-on-kb-cells
#16
JOURNAL ARTICLE
Fatemeh Akbarzadeh, Karim Khoshgard
BACKGROUND: Selective accumulation of photosensitizers into cancerous cells is one of the most important factors affecting photodynamic therapy (PDT) efficacy. 5-aminolevulinic acid (5-ALA) is the precursor of a strong photosensitizer, protoporphyrin-IX; but it has poor permeability into the cells. Folate receptors are overexpressed on the surface of many tumor cells. In the present study, folic acid (FA) and 5-ALA conjugated bismuth oxide nanoparticles were synthesized; and used in PDT, radiotherapy (RT), and concurrent PDT & RT against nasopharyngeal carcinoma (KB cell line)...
February 23, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38395156/a-natural-igm-hitchhiking-strategy-for-delivery-of-cancer-nanovaccines-to-splenic-marginal-zone-b-cells
#17
JOURNAL ARTICLE
Huan Wang, Xiying Wu, Yuhan Sun, Anze Liu, Yingying He, Ziyi Xu, Ying Lu, Changyou Zhan
B cell-targeted cancer vaccines are receiving increasing attention in immunotherapy due to the combined antibody-secreting and antigen-presenting functions. In this study, we propose a natural IgM-hitchhiking delivery strategy to co-deliver tumor antigens and adjuvants to splenic marginal zone B (MZB) cells. We constructed nanovaccines (FA-sLip/OVA/MPLA) consisting of classical folic acid (FA)-conjugated liposomes co-loaded with ovalbumin (OVA) and toll-like receptor 4 agonists, MPLA. We found that natural IgM absorption could be manipulated at the bio-nano interface on FA-sLip/OVA/MPLA, enabling targeted delivery to splenic MZB cells...
February 21, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38391996/impedimetric-detection-of-cancer-markers-based-on-nanofiber-copolymers
#18
JOURNAL ARTICLE
Noha Elnagar, Nada Elgiddawy, Waleed M A El Rouby, Ahmed A Farghali, Hafsa Korri-Youssoufi
The sensitive determination of folate receptors (FRs) in the early stages of cancer is of great significance for controlling the progression of cancerous cells. Many folic acid (FA)-based electrochemical biosensors have been utilized to detect FRs with promising performances, but most were complicated, non-reproducible, non-biocompatible, and time and cost consuming. Here, we developed an environmentally friendly and sensitive biosensor for FR detection. We proposed an electrochemical impedimetric biosensor formed by nanofibers (NFs) of bio-copolymers prepared by electrospinning...
January 31, 2024: Biosensors
https://read.qxmd.com/read/38390840/mir-10b-5p-promotes-tumor-growth-by-regulating-cell-metabolism-in-liver-cancer-via-targeting-slc38a2
#19
JOURNAL ARTICLE
Mingzhi Xia, Jie Chen, Yingyun Hu, Bin Qu, Qianqian Bu, Haoming Shen
Metabolic reprogramming plays a critical role in hepatocarcinogenesis. However, the mechanisms regulating metabolic reprogramming in primary liver cancer (PLC) are unknown. Differentially expressed miRNAs between PLC and normal tissues were identified using bioinformatic analysis. RT-qPCR was used to determine miR-10b-5p and SCL38A2 expression levels. IHC, WB, and TUNEL assays were used to assess the proliferation and apoptosis of the tissues. The proliferation, migration, invasion, and apoptosis of PLC cells were determined using the CCK-8 assay, Transwell assay, and flow cytometry...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38375838/anti-cancer-and-anti-oxidant-effects-of-fenoferin-loaded-human-serum-albumin-nanoparticles-coated-with-folic-acid-bound-chitosan
#20
JOURNAL ARTICLE
Methaq Abid Said Klmohamed Almusawi, Vahid Pouresmaeil, Masoud Homayouni Tabrizi
BACKGROUND: Several diseases, including cancer, can be effectively treated by altering the nanocarrier surfaces so that they are more likely to be targeted. OBJECTIVE: This study aimed to prepare human albumin (HSA) nanoparticles containing Fenoferin (FN) modified with folic acid (FA) attached to Chitosan (CS) to improve its anti-cancer properties. METHODS: Nanoparticles were first synthesized and surface modified. Their physicochemical properties were assessed by different methods, such as FESEM, FTIR, and DLS...
February 19, 2024: Current Molecular Medicine
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