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https://www.readbyqxmd.com/read/28532129/-131-i-traced-plga-lipid-nanoparticles-as-drug-delivery-carriers-for-the-targeted-chemotherapeutic-treatment-of-melanoma
#1
Haiyan Wang, Weizhong Sheng
Herein, folic acid (FA) conjugated Poly(d,l-lactide-co-glycolide) (PLGA)-lipid composites (FA-PL) were developed as nanocarriers for the targeted delivery of insoluble anti-cancer drug paclitaxel (PTX), resulting FA-PLP nanoparticles. Furthermore, (131)I, as a radioactive tracer, was used to label FA-PLP nanoparticles (FA-PLP-(131)I) to evaluate their cell uptake activity, in vivo blood circulation, and biodistribution. The FA-PLP-(131)I nanoparticles had a spherical morphology with great stability, a narrow size distribution (165...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28531877/folate-n-acetyl-glucosamine-conjugated-mesoporous-silica-nanoparticles-for-targeting-breast-cancer-cells-a-comparative-study
#2
Pramod Kumar, Prajakta Tambe, Kishore M Paknikar, Virendra Gajbhiye
Folate receptors (FR) have been well recognized as a marker to target nano-sized carriers for cancer diagnosis and therapy. In contrast, influx transport systems (e.g. GLUT transporters) that transport essential amino acids and nutrients to cancer cells have not been exploited much for targeted delivery. In this study, folic acid- or n-acetyl glucosamine- functionalized mesoporous silica nanoparticles loaded with doxorubicin (DOX-FA-MSNPs or DOX-NAG-MSNPs) were prepared, characterized and compared for targeting along with cytotoxicity towards MCF-7 and MDA-MB-231 human breast cancer cells...
May 11, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28529305/folic-acid-targeted-etoposide-cubosomes-for-theranostic-application-of-cancer-cell-imaging-and-therapy
#3
Yong Tian, Jian-Chun Li, Jin-Xiu Zhu, Na Zhu, Hong-Min Zhang, Lili Liang, Lingyi Sun
BACKGROUND The aim of this study was to develop a novel Poloxamer-based drug delivery system featuring a tumor-targeting folate moiety, which was expected to provide better targeting properties and therapeutic effects compared with the traditional cubosomes (Cubs). MATERIAL AND METHODS Both folate-modified Cubs containing etoposide (ETP-Cubs-FA) and normal cubic nanoparticles loaded with etoposide (ETP-Cubs) were prepared through the fragmentation of bulk gels under the homogenization condition of 1500 bar, and a mean particle size of around 180 nm was obtained with a narrow size distribution...
May 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28525949/capsaicin-loaded-folic-acid-conjugated-lipid-nanoparticles-for-enhanced-therapeutic-efficacy-in-ovarian-cancers
#4
Lin Lv, Yu-Xin Zhuang, Hui-Wu Zhang, Nan-Nan Tian, Wen-Zhen Dang, Shao-Yu Wu
In this study, folic acid-conjugated lipid nanoparticles were successfully prepared to enhance the active targeting of capsaicin (CAP) in ovarian cancers. The particles were nanosized and exhibited a controlled release of drug in the physiological conditions. The folic acid (FA)-conjugated system exhibited a remarkably higher uptake of nanoparticles in the cancer cells compared to that of non-targeted system. The folate-conjugated CAP-loaded lipid nanoparticles (CFLN) upon interacting with cancer cells were internalized via receptor-mediated endocytosis mechanism and resulted in higher concentration in the cancer cells...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28514181/folic-acid-modulates-dmba-tpa-induced-changes-in-skin-of-mice-a-study-relevant-to-carcinogenesis
#5
Ashwani Koul, Navneet Kaur, Neha Arora Chugh
The present study was aimed at investigating the modulatory effects of folic acid (FA) on early stages of chemically induced skin cancer. For this, a two-stage model of skin tumorigenesis was employed. 7,12-Dimethylbenz(a)anthracene (DMBA, 500 nmol/100 ul of acetone) was applied topically for two weeks (twice weekly), followed by phorbol-12-myristate-13-acetate (TPA, 1.7 nmol/100 ul) twice weekly for six weeks on the depilated skin of mice, and FA was administered orally at a dose of 40 microgram/animal for 10 weeks daily...
May 17, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28497681/ph-sensitive-delivery-vehicle-based-on-folic-acid-conjugated-polydopamine-modified-mesoporous-silica-nanoparticles-for-targeted-cancer-therapy
#6
Wei Cheng, Junpeng Nie, Lv Xu, Chaoyu Liang, Yunmei Peng, Gan Liu, Teng Wang, Lin Mei, Laiqiang Huang, Xiaowei Zeng
In this study, we introduced a targeting polymer poly(ethylene glycol)-folic acid (PEG-FA) on the surface of polydopamine (PDA)-modified mesoporous silica nanoparticles (MSNs) to develop the novel nanoparticles (NPs) MSNs@PDA-PEG-FA, which were employed as a drug delivery system loaded with doxorubicin (DOX) as a model drug for cervical cancer therapy. The chemical structure and properties of these NPs were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, N2 adsorption/desorption, dynamic light scattering-autosizer, thermogravimetric analysis, and Fourier transform infrared spectroscopy...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28491851/pemetrexed-induced-acute-kidney-failure-following-irreversible-renal-damage-two-case-reports-and-literature-review
#7
Tito Zattera, Francesco Londrino, Matteo Trezzi, Roberto Palumbo, Antonio Granata, Paola Tatangelo, Valentina Corbani, Valeria Falqui, Nadia Chiappini, Lisa Mathiasen, Marco Cavallini, Davide Rolla
BACKGROUND: Pemetrexed (PEM) is a new-generation multitargeted antifolate agent with a demonstrated broad-spectrum activity in several types of human cancers, including non-small cell lung cancer (NSCLC) and mesothelioma. Major side effects include dose-limiting hematologic toxicities. PEM nephrotoxicity is well known; however, its frequency is considered to be low. CASE PRESENTATION: Here we report two cases of acute kidney injury (AKI) related to PEM administration (500 mg/m2) in patients with NSCLC...
March 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28490863/development-and-evaluation-of-a-new-modular-nanotransporter-for-drug-delivery-into-nuclei-of-pathological-cells-expressing-folate-receptors
#8
Tatiana A Slastnikova, Andrey A Rosenkranz, Yuri V Khramtsov, Tatiana S Karyagina, Sergey A Ovechko, Alexander S Sobolev
PURPOSE: Modular nanotransporters (MNTs) are artificial multifunctional systems designed to facilitate receptor-specific transport from the cell surface into the cell nucleus through inclusion of polypeptide domains for accomplishing receptor binding and internalization, as well as sequential endosomal escape and nuclear translocation. The objective of this study was to develop a new MNT targeted at folate receptors (FRs) for precise delivery of therapeutic cargo to the nuclei of FR-positive cells and to evaluate its potential, particularly for delivery of therapeutic agents (eg, the Auger electron emitter (111)In) into the nuclei of target cancer cells...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28487935/folate-receptor-targeted-ultrasonic-pfob-nanoparticles-synthesis-characterization-and-application-in-tumor-targeted-imaging
#9
Keshi Li, Yahui Liu, Shengmin Zhang, Youfeng Xu, Jianshuai Jiang, Fengying Yin, Yue Hu, Baosan Han, Shuxiong Ge, Li Zhang, Yong Wang
In this study, we aimed to determine an effective strategy for the synthesis of folate receptor (FR) targeted-nanoparticles (FRNPs). The nanoparticles used as ultrasound contrast agents (UCAs) were composed of a liquid core of perfluorooctyl bromide (PFOB) liposome and a targeted shell chemically conjugated with folic acid (FA) and polyethylene glycol (PEG). This was done in order to avoid recognition and clearance by the mononuclear phagocyte system [also known as the reticuloendothelial system (RES)] and enhance the targeting capability of the nanoparticles to tumors overexpressing folate receptor (FR)...
June 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28482586/biodegradable-poly-d-l-lactide-co-glycolide-poly-l-%C3%AE-glutamic-acid-nanoparticles-conjugated-to-folic-acid-for-targeted-delivery-of-doxorubicin
#10
Laura Jaimes-Aguirre, Enrique Morales-Avila, Blanca E Ocampo-García, Luis Alberto Medina, Gustavo López-Téllez, Brenda V Gibbens-Bandala, Vanessa Izquierdo-Sánchez
A novel targeted drug delivery nanoparticle system based on poly(D,L-lactide-co-glycolide) acid (PLGA) for delivery of doxorubicin (DOX) was developed. DOX-PLGA NPs were obtained by the emulsification-solvent evaporation technique. Then, their surface was modified with poly(L-γ-glutamic acid) (γ-PGA) and finally conjugated to modified folic acid (FA) as a targeting ligand. The surface modification and FA conjugation were followed by UV-Vis and FT-IR spectroscopies. Morphology was observed by TEM/SEM. Particle size, PDI and zeta potential were measured using DLS studies...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482577/targeted-delivery-of-bcl-2-conversion-gene-by-mpeg-pcl-pei-fa-cationic-copolymer-to-combat-therapeutic-resistant-cancer
#11
Zibiao Li, Xuan Liu, Xiaohong Chen, Ming Xuan Chua, Yun-Long Wu
Deregulation of anti-apoptosis Bcl-2 protein expression was a key feature in human cancers with therapeutic resistance. Nuclear receptor Nur77 could induce the conformation change of Bcl-2 protein and converted it into an apoptosis inducer by "enemy to friend" strategy. However, the safe and effective delivery of this gene to combat therapeutic resistant cancer remained largely unexplored. In this report, we designed an amphiphilic cationic MPEG-PCL-PEI-FA copolymer, comprising biocompatible and hydrophilic methoxy-poly(ethylene glycol) (MPEG), biodegradable and hydrophobic poly(ε-caprolactone) (PCL), cationic poly(ethylene imine) (PEI) segments, and folic acid (FA) as targeting group, as a high efficient Nur77 gene carrier to folate receptor (FR) highly expressed and therapeutic resistant HeLa/Bcl-2 cancer cells...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482484/folic-acid-tagged-titanium-dioxide-nanoparticles-for-enhanced-anticancer-effect-in-osteosarcoma-cells
#12
Jin-Wei Ai, Bin Liu, Wei-Dong Liu
In this study, folic acid surface modified-Titanium dioxide nanoparticles (FA-TiNP) were prepared as a suitable alternative to conventional chemotherapeutic agents to treat human osteosarcoma. The particle size of TiNP increased marked after polymer assembly on the nanoparticles (NP) surface with a spherical morphology. FA-TiNP exhibited a superior anticancer effect in osteosarcoma cancer cells compared to that of bare TiNP. The reason might due to the specific interaction of FA with the folate receptor which is overexpressed in the cancer cells...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28472908/targeted-nanostructured-lipid-carriers-for-delivery-of-paclitaxel-to-cancer-cells-preparation-characterization-and-cell-toxicity
#13
Mahboubeh Rezazadeh, Jaber Emami, Farshid Hassanzadeh, Hojjat Sadeghi, Mahboubeh Rostami, Hamid Mohammadkhani
Low water solubility, high systemic toxicity and insignificant cellular uptake has limited efficient clinical applications of the anti-tumor agent paclitaxel (PTX). To overcome these limitations, a novel nanostructured lipid carrier (NLC) modified with folic acid (FA) and polyethylene glycol (PEG) was prepared by emulsion solvent evaporation method using cholesterol, α-tocopherol, lecithin and Poloxamer. A partial factorial design was applied to determine the appropriate levels of variables for optimized formulation...
May 3, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28458546/a-generic-89-zr-labeling-method-to-quantify-the-in-vivo-pharmacokinetics-of-liposomal-nanoparticles-with-positron-emission-tomography
#14
Nan Li, Zilin Yu, Truc Thuy Pham, Philip J Blower, Ran Yan
Liposomal nanoparticles are versatile drug delivery vehicles that show great promise in cancer therapy. In an effort to quantitatively measure their in vivo pharmacokinetics, we developed a highly efficient (89)Zr liposome-labeling method based on a rapid ligand exchange reaction between the membrane-permeable (89)Zr(8-hydroxyquinolinate)4 complex and the hydrophilic liposomal cavity-encapsulated deferoxamine (DFO). This novel (89)Zr-labeling strategy allowed us to prepare radiolabeled forms of a folic acid (FA)-decorated active targeting (89)Zr-FA-DFO-liposome, a thermosensitive (89)Zr-DFO-liposome, and a renal avid (89)Zr-PEG-DFO-liposome at room temperature with near-quantitative isolated radiochemical yields of 98%±1% (n=6), 98%±2% (n=5), and 97%±1% (n=3), respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28456287/bimetallic-bi-pt-peroxidase-mimic-and-its-bioanalytical-applications
#15
Gang-Wei Wu, Yi-Min Shen, Xiao-Qiong Shi, Hao-Hua Deng, Xiao-Qing Zheng, Hua-Ping Peng, Ai-Lin Liu, Xing-Hua Xia, Wei Chen
In this work, bimetallic Bi/Pt nanoparticles in bovine serum albumin biomolecular scaffold (BSA-Bi/PtNPs) were synthesized through a facile and green method. As compared with BSA-PtNPs, the BSA-Bi/PtNPs possess enhanced peroxidase-like catalytic activity. Moreover, the BSA-Bi/PtNPs are stable in harsh conditions such as high temperature, extreme pH environments, and high ionic strength, as well as in common biological matrixes. These prominent advantages enable the BSA-Bi/PtNPs to be applied to a wide range of fields...
June 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28453929/synthesis-of-lipophilic-core-shell-fe3o4-sio2-au-nanoparticles-and-polymeric-entrapment-into-nanomicelles-a-novel-nanosystem-for-in-vivo-active-targeting-and-magnetic-resonance-photoacoustic-dual-imaging
#16
Ilaria Monaco, Francesca Arena, Stefania Biffi, Erica Locatelli, Barbara Bortot, Francesca La Cava, Giada Maria Marini, Giovanni Maria Severini, Enzo Terreno, Mauro Comes Franchini
In this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer.
May 17, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28452577/novel-nano-sized-liposome-encapsulated-polyamidoamine-dendrimer-derivatives-facilitate-tumour-targeting-by-overcoming-the-polyethylene-glycol-dilemma-and-integrin-saturation-obstacle
#17
Gang Li, Yan-Zhi Song, Zhen-Jun Huang, Kang Chen, Dawei Chen, Yi-Hui Deng
Drug delivery systems (DDSs) commonly employ arginine-glycine-aspartic acid (RGD) peptides with polyethylene glycol (PEG)-dependent enhanced permeability and retention (EPR) effect to optimize tumour-targeting. However, the PEG dilemma and integrin saturation obstacle are major challenges. To address these issues, we constructed a novel, nano-sized DDS by encapsulating doxorubicin (DOX)-loaded folic acid derivatives of polyamidoamine dendrimer (PAMAM G5.0) in cyclic RGD-tyrosine-lysine pentapeptide (c[RGDyK])-modified liposomes (RGD-SL[FND/DOX]), prepared using thin-film hydration, film-dispersion, and hydration-sonication...
April 28, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28451831/enhancing-the-therapeutic-range-of-a-targeted-small-molecule-tubulysin-conjugate-for-folate-receptor-based-cancer-therapy
#18
Christopher P Leamon, Joseph A Reddy, Iontcho R Vlahov, Ryan Dorton, Alicia Bloomfield, Marilynn Vetzel, Patrick J Klein, Elaine Westrick, Le-Cun Xu, Yu Wang
PURPOSE: EC0305 represents a folate-tubulysin B construct capable of specifically eradicating folate receptor (FR)-positive subcutaneous tumors from mice (Leamon et al., Cancer Res 68:9839-9844, 8). Herein we report on the use of multiple polar carbohydrate segments (e.g. 1-amino-1-deoxy-glucitolyl-γ-glutamate) placed in-between the folate and tubulysin B moieties of EC0305 creating a new conjugate, herein referred to as EC0531, with more desirable biological properties. METHODS: The synthesis of EC0531 and its tritium-labeled counterpart are described...
June 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28444786/targeted-photodynamic-therapy-with-a-folate-sensitizer-assembly-produced-from-mesoporous-silica
#19
Salvatore Sortino, Chunfang Zhou, Damien Afonso, Sabrina Valetti, Adam Feiler, Venera Cardile, Adriana Graziano, Sabrina Conoci
A mesoporous silica material prepared by using folic acid (FA) as a template enables the effective encapsulation of meso-tetrakis(4-carboxyphenyl)porphyrin (TCPP) in its interior. Combination of steady-state and time-resolved absorption and emission spectroscopy demonstrate that FA and TCPP are released from the silica material to aqueous phase in the form of a non-covalent assembly. This assembly does not form by simple mixing of the two components in the absence of silica, suggesting the key role of the material in the assembling process...
April 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28438704/folic-acid-decorated-polyamidoamine-dendrimer-exhibits-high-tumor-uptake-and-sustained-highly-localized-retention-in-solid-tumors-its-utility-for-local-sirna-delivery
#20
Leyuan Xu, W Andrew Yeudall, Hu Yang
The utility of folic acid (FA)-decorated polyamidoamine dendrimer G4 (G4-FA) as a vector was investigated for local delivery of siRNA. In a xenograft HN12 (or HN12-YFP) tumor mouse model of head and neck squamous cell carcinomas (HNSCC), intratumorally (i.t.) injected G4-FA exhibited high tumor uptake and sustained highly localized retention in the tumors according to near infrared (NIR) imaging assessment. siRNA against vascular endothelial growth factor A (siVEGFA) was chosen as a therapeutic modality. Compared to the nontherapeutic treatment groups (PBS solution or dendrimer complexed with nontherapeutic siRNA against green fluorescent protein (siGFP)), G4-FA/siVEGFA showed tumor inhibition effects in single-dose and two-dose regimen studies...
April 22, 2017: Acta Biomaterialia
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